23 results on '"Puscas, Tania"'
Search Results
2. Target population for a selective cardiac myosin inhibitor in hypertrophic obstructive cardiomyopathy: Real-life estimation from the French register of hypertrophic cardiomyopathy (REMY)
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Parodi, Alessandro, Puscas, Tania, Réant, Patricia, Donal, Erwan, M’Barek Raboudi, Dorra, Billon, Clarisse, Bacher, Anne, El Hachmi, Mohamed, Wahbi, Karim, Jeunemaître, Xavier, and Hagège, Albert
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- 2024
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3. First-in-man use of a cardiovascular cell-derived secretome in heart failure. Case report
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Menasché, Philippe, Renault, Nisa K., Hagège, Albert, Puscas, Tania, Bellamy, Valérie, Humbert, Camille, Le, Laetitia, Blons, Hélène, Granier, Clémence, Benhamouda, Nadine, Bacher, Anne, Churlaud, Guillaume, Sabatier, Brigitte, and Larghero, Jérôme
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- 2024
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4. Initiation and development of a percutaneous left atrial appendage closure programme: A French centre's experience and literature review
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Albert, Emeric, Puscas, Tania, Seret, Gabriel, Tence, Noémie, Amet, Denis, Varlet, Emilie, M’Barek, Dorra Raboudi, Picard, Fabien, Otmani, Akli, Sabbah, Laurent, Le Guen, Julien, Bodiguel, Eric, Domigo, Valerie, Soulat, Gilles, Spaulding, Christian, and Marijon, Eloi
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- 2023
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5. Does Atrial Septal Anatomy Still Matter in the Etiological Evaluation of Ischemic Stroke Beyond the Age of 60?
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Dusonchet, Antoine, primary, Varenne, Olivier, additional, Puscas, Tania, additional, Saadi, Malika, additional, Hagege, Albert, additional, Calvet, David, additional, Mas, Jean‐Louis, additional, and Turc, Guillaume, additional
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- 2024
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6. The French Hypertrophic Cardiomyopathy Gene Register: A Systematic Large Gene Screening for Hypertrophic Cardiomyopathy
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Hagege, Albert Alain, primary, Puscas, Tania, additional, el hachmi, Mohamed, additional, Parodi, Alessandro, additional, Bacher, Anne, additional, Funalot, Benoit, additional, Wahbi, Karim, additional, jeunemaitre, xavier, additional, Damy, Thibaud, additional, and Billon, Clarise, additional
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- 2024
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7. Corrigendum to “The French hypertrophic cardiomyopathy gene register: A systematic large gene screening for hypertrophic cardiomyopathy” [International Journal of Cardiology Volume 417, 15 December 2024, 132542]
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Hagège, Albert, Puscas, Tania, El Hachmi, Mohamed, Parodi, Alessandro, Bacher, Anne, Funalot, Benoit, Wahbi, Karim, Jeunemaître, Xavier, Damy, Thibaud, and Billon, Clarisse
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- 2025
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8. Transcatheter Tricuspid Repair for Tricuspid Regurgitation After Heart Transplantation
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Puscas, Tania, primary, Gautier, Charles-Henri, additional, Martin, Anne-Céline, additional, Pechmajou, Louis, additional, Du Puy-Montbrun, Leonora, additional, Caudron, Julia, additional, Guillemain, Romain, additional, Bories, Marie-Cécile, additional, Achouh, Paul, additional, and Karam, Nicole, additional
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- 2023
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9. Staging Heart Failure Patients With Secondary Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair
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Stolz, Lukas, primary, Doldi, Philipp M., additional, Orban, Mathias, additional, Karam, Nicole, additional, Puscas, Tania, additional, Wild, Mirjam G., additional, Popescu, Aniela, additional, von Bardeleben, Ralph Stephan, additional, Iliadis, Christos, additional, Baldus, Stephan, additional, Adamo, Marianna, additional, Thiele, Holger, additional, Besler, Christian, additional, Unterhuber, Matthias, additional, Ruf, Tobias, additional, Pfister, Roman, additional, Higuchi, Satoshi, additional, Koell, Benedikt, additional, Giannini, Christina, additional, Petronio, Anna, additional, Kassar, Mohammad, additional, Weckbach, Ludwig T., additional, Butter, Christian, additional, Stocker, Thomas J., additional, Neuss, Michael, additional, Melica, Bruno, additional, Braun, Daniel, additional, Windecker, Stephan, additional, Massberg, Steffen, additional, Praz, Fabien, additional, Näbauer, Micheal, additional, Kalbacher, Daniel, additional, Lurz, Philipp, additional, Metra, Marco, additional, Bax, Jeroen J., additional, and Hausleiter, Jörg, additional
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- 2023
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10. 185 BETA-BLOCKERS OR CALCIUM CHANNEL BLOCKERS IN HYPERTROPHIC CARDIOMYOPATHY
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Pinto, Giuseppe, primary, Chiarito, Mauro, additional, Bacher, Anne, additional, Puscas, Tania, additional, Condorelli, Gianluigi, additional, Reant, Patricia, additional, Donal, Erwan, additional, and Hagege, Albert, additional
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- 2022
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11. Transbronchial cryobiopsy proven amyloid diffuse cystic lung disease complicating a transthyretin mutated (ATTRm) amyloidosis: a case report.
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Gaultier, Sébastien, Puscas, Tania, Pastre, Jean, Gibault, Laure, Arlet, Jean-Benoît, Cauquil, Cécile, and Michon, Adrien
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CARDIAC amyloidosis ,TRANSTHYRETIN ,LUNG diseases ,AMYLOIDOSIS ,CARPAL tunnel syndrome ,AMYLOID - Abstract
We present a case report of transbronchial cryobiopsy proven diffuse amyloid cystic lung disease complicating a homozygous Val122Ile (V122I) transthyretin mutated amyloidosis (ATTRm). To the best of our knowledge, this is the first case in the literature reporting such pulmonary lesions in ATTRm amyloidosis, and notably diagnosed through cryobiopsy. A 51-year-old man from Mali with a past medical history of bilateral carpal tunnel syndrome presented erectile dysfunction, asthenia and worsening dyspnoea over the past year. He presented signs of cardiac failure; histological and radiological investigations diagnosed cardiac amyloidosis. He was found homozygote for the V122I mutation in transthyretin. A diffuse cystic lung disease (DCLD) was noted on computed tomography (CT) scan. We performed a transbronchial pulmonary cryobiopsy that revealed histological transthyretin amyloid deposits. This case report illustrates the safety and usefulness of cryobiopsy in the setting of DCLD and extends ATTRm amyloidosis as a possible cause of DCLD. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Left atrial volume index and outcome after transcatheter edge‐to‐edge valve repair for secondary mitral regurgitation
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Iliadis, Christos, primary, Kalbacher, Daniel, additional, Lurz, Philipp, additional, Petrescu, Aniela Monica, additional, Orban, Mathias, additional, Puscas, Tania, additional, Lupi, Laura, additional, Stazzoni, Laura, additional, Pires‐Morais, Gustavo, additional, Koell, Benedikt, additional, Besler, Christian, additional, Ruf, Tobias Friedrich, additional, Stolz, Lukas, additional, Tence, Noemie, additional, Adamo, Marianna, additional, Giannini, Cristina, additional, Guerreiro, Cláudio, additional, Hellmich, Martin, additional, Baldus, Stephan, additional, Schofer, Niklas, additional, Thiele, Holger, additional, von Bardeleben, Ralph Stephan, additional, Hausleiter, Jörg, additional, Karam, Nicole, additional, Metra, Marco, additional, Petronio, Anna Sonia, additional, Melica, Bruno, additional, and Pfister, Roman, additional
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- 2022
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13. Left atrial volume index and outcome after transcatheter edge-to-edge valve repair for secondary mitral regurgitation
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Iliadis, Christos, Kalbacher, Daniel, Lurz, Philipp, Petrescu, Aniela Monica, Orban, Mathias, Puscas, Tania, Lupi, Laura, Stazzoni, Laura, Pires-Morais, Gustavo, Koell, Benedikt, Besler, Christian, Ruf, Tobias Friedrich, Stolz, Lukas, Tence, Noemie, Adamo, Marianna, Giannini, Cristina, Guerreiro, Claudio, Hellmich, Martin, Baldus, Stephan, Schofer, Niklas, Thiele, Holger, von Bardeleben, Ralph Stephan, Hausleiter, Joerg, Karam, Nicole, Metra, Marco, Petronio, Anna Sonia, Melica, Bruno, Pfister, Roman, Iliadis, Christos, Kalbacher, Daniel, Lurz, Philipp, Petrescu, Aniela Monica, Orban, Mathias, Puscas, Tania, Lupi, Laura, Stazzoni, Laura, Pires-Morais, Gustavo, Koell, Benedikt, Besler, Christian, Ruf, Tobias Friedrich, Stolz, Lukas, Tence, Noemie, Adamo, Marianna, Giannini, Cristina, Guerreiro, Claudio, Hellmich, Martin, Baldus, Stephan, Schofer, Niklas, Thiele, Holger, von Bardeleben, Ralph Stephan, Hausleiter, Joerg, Karam, Nicole, Metra, Marco, Petronio, Anna Sonia, Melica, Bruno, and Pfister, Roman
- Abstract
Aims To investigate the role of left atrial volume index (LAVi) in patients with secondary mitral regurgitation (SMR) undergoing transcatheter edge-to-edge mitral valve repair (TEER). Methods and results Outcomes were evaluated in SMR patients of a European multicentre registry according to baseline LAVi. Main analysis was performed for all-cause mortality; residual mitral regurgitation (MR) and New York Heart Association (NYHA) class improvement were analysed for patients available. A total of 1074 patients were included with a median LAVi (interquartile range) of 58 ml/m(2) (46-73). Postprocedural reduction of MR grade to <= 2+ was similar across LAVi quintiles, ranging 91%-96% (p = 0.26). Symptomatic benefit (>= 1 NYHA class improvement) also did not differ by LAVi quintiles (61%-68% of patients) (p = 0.66). The risk of mortality increased by 23%-42% in the four upper quintiles compared to the bottom quintile (LAVi <42 ml/m(2)). The hazard ratio (HR) of mortality was 1.35 (95% confidence interval [CI] 1.02-1.78, p = 0.035) associated with a LAVi >42 ml/m(2), which was attenuated after multivariable adjustment (HR 1.18, 95% CI 0.83-1.67, p = 0.36). A significant interaction was found for MR severity and pulmonary hypertension, with an increased risk of death associated with enlarged LAVi in patients with inframedian effective regurgitant orifice area (HR 1.99, 95% CI 1.06-3.74, p = 0.032) and in patients with systolic pulmonary pressure <= 50 mmHg (HR 1.67, 95% CI 1.02-2.75, p = 0.042) in multivariable analysis. Conclusion Procedural success and symptomatic benefit were high throughout the whole range of LAVi. The prognostic impact of left atrial enlargement was relevant in patients with less severe SMR and without pulmonary hypertension, reinforcing the need to identify patients in the early course of backward congestion to achieve good long-term outcome after TEER.
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- 2022
14. Epidemiology, Pathophysiology, and Management of Native Atrioventricular Valve Regurgitation in Heart Failure Patients
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Martin, Anne-Céline, primary, Bories, Marie-Cécile, additional, Tence, Noemie, additional, Baudinaud, Pierre, additional, Pechmajou, Louis, additional, Puscas, Tania, additional, Marijon, Eloi, additional, Achouh, Paul, additional, and Karam, Nicole, additional
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- 2021
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15. Management and outcomes of hypertrophic cardiomyopathy in young adults
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Baron, Émilie, primary, Karam, Nicole, additional, Donal, Erwan, additional, Puscas, Tania, additional, Mirabel, Mariana, additional, Bacher, Anne, additional, Wahbi, Karim, additional, Mazzella, Jean-Michael, additional, Jeunemaitre, Xavier, additional, Reant, Patricia, additional, and Hagège, Albert, additional
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- 2021
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16. Impact of Proportionality of Secondary Mitral Regurgitation on Outcome After Transcatheter Mitral Valve Repair
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Orban, Mathias, primary, Karam, Nicole, additional, Lubos, Edith, additional, Kalbacher, Daniel, additional, Braun, Daniel, additional, Deseive, Simon, additional, Neuss, Michael, additional, Butter, Christian, additional, Praz, Fabien, additional, Kassar, Mohammad, additional, Petrescu, Aniela, additional, Pfister, Roman, additional, Iliadis, Christos, additional, Unterhuber, Matthias, additional, Lurz, Philipp, additional, Thiele, Holger, additional, Baldus, Stephan, additional, Stephan von Bardeleben, Ralph, additional, Blankenberg, Stefan, additional, Massberg, Steffen, additional, Windecker, Stephan, additional, Hausleiter, Jörg, additional, Orban, Mathias, additional, Stolz, Lukas, additional, Orban, Martin, additional, Näbauer, Michael, additional, Puscas, Tania, additional, Tence, Noemie, additional, Latremouille, Christian, additional, Westermann, Dirk, additional, Schofer, Niklas, additional, Ludwig, Sebastian, additional, Bannehr, Marvin, additional, Kücken, Tanja, additional, Edlinger, Christoph, additional, Hähnel, Valentin, additional, Brugger, Nicolas, additional, Pilgrim, Thomas, additional, Winkel, Mirjam G., additional, von Bardeleben, Stephan, additional, Körber, Maria, additional, Mauri, Viktor, additional, Wösten, Monique, additional, Stephan Baldus, Clemens Metze, additional, Noack, Thilo, additional, Borger, Michael, additional, Blazek, Stephan, additional, and Desch, Steffen, additional
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- 2021
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17. Predictive Factor for COVID-19 Worsening: Insights for High-Sensitivity Troponin and D-Dimer and Correlation With Right Ventricular Afterload
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Goudot, Guillaume, primary, Chocron, Richard, additional, Augy, Jean-Loup, additional, Gendron, Nicolas, additional, Khider, Lina, additional, Debuc, Benjamin, additional, Aissaoui, Nadia, additional, Peron, Nicolas, additional, Hauw-Berlemont, Caroline, additional, Vedie, Benoit, additional, Cheng, Charles, additional, Mohamedi, Nassim, additional, Krzisch, Daphné, additional, Philippe, Aurélien, additional, Puscas, Tania, additional, Hermann, Bertrand, additional, Brichet, Julie, additional, Juvin, Philippe, additional, Planquette, Benjamin, additional, Messas, Emmanuel, additional, Pere, Hélène, additional, Veyer, David, additional, Gaussem, Pascale, additional, Sanchez, Olivier, additional, Diehl, Jean-Luc, additional, Mirault, Tristan, additional, and Smadja, David M., additional
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- 2020
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18. Temporal Trends in Transcatheter Aortic Valve Replacement in France: FRANCE 2 to FRANCE TAVI
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Auffret, Vincent, Lefevre, Thierry, Belle, Eric, Eltchaninoff, Hélène, Iung, Bernard, Koning, René, Motreff, Pascal, Leprince, Pascal, Philippe, Philippe, Manigold, Thibaut, Souteyrand, Geraud, Boulmier, Dominique, Joly, Patrick, Pinaud, Frédéric, Himbert, Dominique, Collet, Philippe, Rioufol, Gilles, Ghostine, Said, Bar, Olivier, Dibie, Alain, Champagnac, Didier, Leroux, Lionel, Collet, Frédéric, Teiger, Emmanuel, Darremont, Olivier, Folliguet, Thierry, Leclercq, Florence, Lhermusier, Thibault, Olhmann, Patrick, Huret, Bruno, Lorgis, Luc, Drogoul, Laurent, Bertrand, Bernard, Spaulding, Christian, Quilliet, Laurent, Cuisset, Thomas, Delomez, Max, Beygui, Farzin, Claudel, Philippe, Hepp, Alain, Jégou, Arnaud, Gommeaux, Antoine, Mirode, Anfani, Christiaens, Luc, Christophe, Christophe, Cassat, Claude, Metz, Damien, MANGIN, Lionel, Isaaz, Karl, Jacquemin, Laurent, Guyon, Philippe, Pouillot, Christophe, Makowski, Serge, Bataille, Vincent, Rodes-Cabau, Josep, Gilard, Martine, Laskar, Marc, Chevalier, Bernard, Hovasse, Thomas, Donzeau Gouge, Patrick, Farge, Arnaud, Romano, Mauro, Bertrand, Bertrand, Bouvier, Erik, Bauchart, Jean, Delhaye, Cédric, Houpe, David, Robert, Robert, Leroy, Fabrice, Sudre, Arnaud, Juthier, Francis, Koussa, Mohamed, Modine, Thomas, Rousse, Natacha, Auffray, Jean, Richard, Richard, Berland, Jacques, Godin, Mathieu, Bessou, Jean, Letocart, Vincent, Roussel, Jean, Combaret, Nicolas, d’Ostrevy, Nicolas, Innorta, Andrea, Clerfond, Guillaume, Vorilhon, Charles, Bedossa, Marc, Leurent, Guillaume, Anselmi, Amedeo, Harmouche, Majid, Donal, Erwan, Bille, Jacques, Houel, Rémi, Abi Khalil, Wissam, Delepine, Stéphane, Fouquet, Olivier, Roule, Frédéric, Abtan, Jérémie, Urena, Marina, Alkhoder, Soleiman, Ghodbane, Walid, Arangalage, Dimitri, Brochet, Eric, Goublaire, Coppelia, Choussat, Rémi, Lebreton, Guillaume, Mastrioanni, Chiro, Dauphin, Raphaël, Dubreuil, Olivier, Durand de Gevigney, Guy, Finet, Gérard, Harbaoui, Brahim, Ranc, Sylvain, Farhat, Fadi, Jegaden, Olivier, Obadia, Jean, Pozzi, Matteo, Ghostine, Saïd, Fradi, Sahbi, Azmoun, Alexandre, Kauffmann, Martin, Blanchard, Didier, Chassaing, Stephan, Chatel, Didier, Le Page, Olivier, Tauran, Arnaud, Bruere, Didier, Bodson, Laurent, Meurisse, Yvon, Seemann, Aurélie, AMABILE, NICOLAS, Simon, Simon, Drieu, Luc, Ohanessian, Alice, Veugeois, Aurélie, Debauchez, Matthieu, Zannis, Konstantinos, Czitrom, Daniel, Diakov, Chrystelle, Raoux, François, Lienhart, Yves, Staat, Patrick, Zouaghi, Oualid, Doisy, Vincent, Frieh, Philippe, Wautot, Fabrice, Dementhon, Julie, Garrier, Olivier, Jamal, Fadi, Leroux, Pierre, Casassus, Frédéric, Séguy, Benjamin, Barandon, Laurent, Labrousse, Louis, Peltan, Julien, Cornolle, Claire, Dijos, Marina, Lafitte, Stephane, Bayet, Gilles, Charmasson, Claude, Vaillant, Alain, Vicat, Jacques, Giacomoni, Marie Paule, Bergoend, Eric, Zerbib, Céline, Louis Leymarie, Jean, Clerc, Philippe, Choukroun, Emmanuel, Elia, Nicolas, Grimaud, Philippe, Guibaud, Philippe, Wroblewski, Stéphane, Abergel, Eric, Bogino, Emmanuel, Dehant, Patrick, Simon, Marc, Angioi, Michel, Lemoine, Julien, Lemoine, Simon, Popovic, Batric, Maureira, Pablo, Huttin, Olivier, Selton Suty, Christine, Cayla, Guillaume, Delseny, Delphine, Levy, Gilles, Maupas, Eric, Rivalland, François, Robert, Gabriel, Schmutz, Laurent, Targosz, Frédéric, Albat, Bernard, Dubar, Arnaud, Durrleman, Nicolas, Gandet, Thomas, Munos, Emmanuel, Cade, Stéphane, Cransac, Frédéric, Bouisset, Frédéric, Grunenwald, Etienne, Bertrand, Marc, Fournier, Pauline, Morel, Olivier, Ohlmann, Patrick, Kindo, Michel, Hoang, Minh Tam, Petit, Hélène, Samet, Hafida, Trinh, Anne, Lecoq, Guillaume, Morelle, Jean François, Richard, Pascal, Derieux, Thierry, Monier, Emmanuel, Joret, Cédric, Bouchot, Olivier, Meyer, Pierre, Lopez, Stéphane, Tapia, Michel, Teboul, Jacques, Elbeze, Pierre, Mihoubi, Alain, Vanzetto, Gérald, Wittenberg, Olivier, Bach, Vincent, Martin, Cécile, Sauier, Carole, Casset, Charlotte, Castellant, Philippe, Bezon, Eric, Choplain, Jean, Kallifa, Ahmed, Nasr, Bahaa, Jobic, Yannick, Lafont, Antoine, Pagny, Jean, Abi Akar, Ramzi, Fabiani, Jean, Zegdi, Rachid, Berrebi, Alain, Puscas, Tania, Desveaux, Bernard, Ivanes, Fabrice, Bourguignon, Thierry, Aupy, Blandine, Perault, Romain, Bonnet, Jean, Lambert, Marc, Grisoli, Dominique, Jaussaud, Nicolas, Salaün, Erwan, Laghzaoui, Amine, Savoye, Christine, Bignon, Mathieu, Roule, Vincent, Sabatier, Rémy, Ivascau, Calin, Saplacan, Vladimir, Saloux, Eric, Bouchayer, Damien, Tremeau, Guillaume, Diab, Camille, Lapeze, Joel, Pelissier, Franck, Sassard, Thomas, Matz, Catherine, Monsarrat, Nicolas, Carel, Ivan, Sibellas, Franck, Curtil, Alain, Dambrin, Grégoire, Favereau, Xavier, Ghorayeb, Gabriel, Guesnier, Laurent, Khoury, Wassim, Pouzet, Bruno, Vaislic, Claude, Cheikh-Khelifa, Riadh, Hilpert, Loïc, Maribas, Philippe, Hannebicque, Gery, Hochart, Philippe, Paris, Marc, Pecheux, Max, Fabre, Olivier, Leborgne, Laurent, Peltier, Marcel, Le Breton, Hervé, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], Hôpital Privé Jacques Cartier [Massy], Pole Cardio-vasculaire et pulmonaire [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires (RNMCD - U1011), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de cardiologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de cardiologie [CHU Bichat], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot, Sorbonne Paris Cité, Clinique St Hilaire ( Service de Cardiologie, Rouen), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie cardiaque et thoracique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Cardiologie [Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Saint-Joseph [Marseille], Service de chirurgie cardio-vasculaire et thoracique, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Service de cardiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut de cardiologie [CHU Pitié-Salpêtrière], Hôpital Cardiovasculaire Louis Pradel, Hospices Civils de Lyon (HCL), Centre Chirurgical Marie Lannelongue (CCML), Clinique St Gatien et Groupe Athérome Cardiologie Interventionnelle/SF, Clinique St Gatien, Institut Mutualiste de Montsouris (IMM), Clinique du Tonkin, Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Hôpital Privé Clairval [Marseille], Centre d'Investigation Clinique Henri Mondor (CIC Henri Mondor), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Clinique Saint Augustin, Service de Cardiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de cardiologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de cardiologie [Toulouse], CHU Strasbourg, Hôpital Privé Saint Martin Caen, Service de Cardiologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Institut Arnaud Tzanck, Centre Hospitalier Universitaire [Grenoble] (CHU), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Cardiologie (CHU Trousseau, Tours), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Nanomédecine Régénérative (NanoRegMed), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Polyclinic du Bois, Service de cardiologie et de pathologie vasculaire [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Infirmerie Protestante Lyon Caluire, parent, Clinique de la Sauvegarde [Lyon], Parly II Private Hospital, Le Chesnay, Hôpital privé Bois-Bernard, Service de Cardiologie [Amiens], CHU Amiens-Picardie, Hôpital de la Milétrie, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Hôpital Dupuytren [CHU Limoges], Hôpital universitaire Robert Debré [Reims], Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Hôpital Nord (Saint Etienne), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Centre cardiologique du Nord (CCN), Clinique Sainte Clotilde, Hôpital Ambroise Paré [AP-HP], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval [Québec] (ULaval), Optimisation des régulations physiologiques (ORPHY (EA 4324)), Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Unité de Taphonomie médico-légale et Anatomie - ULR 7367 (UTML&A), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hémostase et pathologie cardiovasculaire, EA2693-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, chirurgie thoracique et cardio-vasculaire, Service de chirurgie cardiaque, Service de chirurgie thoracique cardiaque et vasculaire [Rennes] = Thoracic and Cardiovascular Surgery [Rennes], Microbiology Institute of CHUV, Service de Cardiologie de l'hopital de la Croix Rousse, Department of Hemodynamics and Interventional Cardiology, Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiology Department, European Society of Hypertension Excellence Center, Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service de chirurgie cardiaque et transplantation, Hôpital Louis Pradel [CHU - HCL], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle Cardiologie Interventionnelle / Coro-scanner / IRM Cardiaque, Clinique Saint Gatien, Hôpital nord, St Etienne, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Département de cardiologie, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], Adaptation cardiovasculaire à l'ischemie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie cardio-vasculaire, Service de Cardiologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], École de chirurgie, faculté de médecine de Nancy, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de chirurgie thoracique et cardio-vasculaire, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Université de Montpellier (UM), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), European Synchrotron Radiation Facility (ESRF), Service de Cardiologie (BREST - Cardio), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service d'urologie, Clinique Cardiologie et Hypertension Artérielle, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Clinique de chirurgie cardiaque, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service de Cardiologie, Brest, Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), Développement artériel, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Gynécologie‑Obstétrique, Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardique (SEILIRM), Normandie Université (NU)-Normandie Université (NU), Service de cardiologie et maladies vasculaires [CHU de Rennes], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Gabriel Montpied (CHU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Henri Mondor-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pathologie cardiaque, Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], CHU Dijon, Rayonnement Synchrotron et Recherche Medicale (RSRM), Université Joseph Fourier - Grenoble 1 (UJF)-European Synchrotron Radiation Facility (ESRF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Cardiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Epidémiologie et Biostatistique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Universitaire de Clermont-Ferrand, Service de chirurgie thoracique cardiaque et vasculaire [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service de Chirurgie Thoracique et Cardiovasculaire [CHU Pitié-Salpêtrière], Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Sorbonne Université, Hôpital Arnaud de Villeneuve-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Hôpital Paule de Viguier, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre chirurgical Marie Lannelongue, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire Traitement du Signal et de l'Image ( LTSI ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de cardiologie [Rouen], CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ), Clinique St Hilaire ( Service de Cardiologie, Rouen ), CHU Gabriel Montpied ( CHU ), Assistance publique - Hôpitaux de Paris - AP-HP (FRANCE), CHU Angers, Hospices Civils de Lyon ( HCL ), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre d'Investigation Clinique Henri Mondor ( CIC Henri Mondor ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Institut Mutualiste de Montsouris ( IMM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Rayonnement Synchrotron et Recherche Medicale ( RSRM ), Université Joseph Fourier - Grenoble 1 ( UJF ) -ESRF-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Paris-Centre de Recherche Cardiovasculaire ( PARCC - U970 ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Nutrition, obésité et risque thrombotique ( NORT ), Aix Marseille Université ( AMU ) -Institut National de la Recherche Agronomique ( INRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Épidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut Universitaire de Cardiologie et de Pneumologie de Québec ( IUCPQ ), Université Laval, Optimisation des régulations physiologiques ( ORPHY (EA 4324) ), Université de Brest ( UBO ) -Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ) -Institut Brestois Santé Agro Matière ( IBSAM ), Université de Brest ( UBO ) -Université de Brest ( UBO ), Unité de Taphonomie médico-légale ( UTML ), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), EA2693-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé, Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Hôpital Louis Pradel [CHU - HCL], Cardiovasculaire, métabolisme, diabétologie et nutrition ( CarMeN ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Hospices Civils de Lyon ( HCL ) -Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Institut National de la Recherche Agronomique ( INRA ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Saint-Antoine [APHP], Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Imagerie Adaptative Diagnostique et Interventionnelle ( IADI ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lorraine ( UL ), Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Arnaud de Villeneuve, Institut des Maladies Métaboliques et Cardiovasculaires ( I2MC ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), European Synchrotron Radiation Facility ( ESRF ), Service de Cardiologie ( BREST - Cardio ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-Hôpital Michallon, Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble, Université Grenoble Alpes - UFR Médecine ( UGA UFRM ), Université Grenoble Alpes ( UGA ), Hôpital de la Cavale Blanche - CHRU Brest ( CHU - BREST ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardique ( SEILIRM ), Université de Caen Normandie ( UNICAEN ), Départment de cardiologie [Caen], Normandie Université ( NU ) -Normandie Université ( NU ) -CHU Caen, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Cardiologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Gynécologie [CHU Toulouse], Pôle Femme-Mère-Couple [CHU Toulouse], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Unité de Taphonomie médico-légale (UTML), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, and Université Grenoble Alpes (UGA)
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[ SDV ] Life Sciences [q-bio] ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV]Life Sciences [q-bio] ,transfemoral ,national registry ,[ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,outcomes ,pacemaker - Abstract
International audience; Background - Transcatheter aortic valve replacement (TAVR) is standard therapy for patients with severe aortic stenosis who are at high surgical risk. However, national data regarding procedural characteristics and clinical outcomes over time are limited. Objectives - The aim of this study was to assess nationwide performance trends and clinical outcomes of TAVR during a 6-year period. Methods - TAVRs performed in 48 centers across France between January 2013 and December 2015 were prospectively included in the FRANCE TAVI (French Transcatheter Aortic Valve Implantation) registry. Findings were further compared with those reported from the FRANCE 2 (French Aortic National CoreValve and Edwards 2) registry, which captured all TAVRs performed from January 2010 to January 2012 across 34 centers. Results - A total of 12,804 patients from FRANCE TAVI and 4,165 patients from FRANCE 2 were included in this analysis. The median age of patients was 84.6 years, and 49.7% were men. FRANCE TAVI participants were older but at lower surgical risk (median logistic European System for Cardiac Operative Risk Evaluation [EuroSCORE]: 15.0% vs. 18.4%; p < 0.001). More than 80% of patients in FRANCE TAVI underwent transfemoral TAVR. Transesophageal echocardiography guidance decreased from 60.7% to 32.3% of cases, whereas more recent procedures were increasingly performed in hybrid operating rooms (15.8% vs. 35.7%). Rates of Valve Academic Research Consortium-defined device success increased from 95.3% in FRANCE 2 to 96.8% in FRANCE TAVI (p < 0.001). In-hospital and 30-day mortality rates were 4.4% and 5.4%, respectively, in FRANCE TAVI compared with 8.2% and 10.1%, respectively, in FRANCE 2 (p
- Published
- 2017
19. Prognostic value of the 12-lead surface electrocardiogram in sarcomeric hypertrophic cardiomyopathy: data from the REMY French register.
- Author
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Ledieu, Nicolas, Larnier, Louis, Auffret, Vincent, Marie, Coralie, Fargeau, Dominique, Donal, Erwan, Mirabel, Mariana, Jeunemaitre, Xavier, Puscas, Tania, Marijon, Eloi, Reynaud, Amélie, Ritter, Philippe, Lafitte, Stephane, Mabo, Philippe, Réant, Patricia, Daubert, Claude, Hagège, Albert A, Cardiology, REMY Working Group of the French Society of, and REMY Working Group of the French Society of Cardiology
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RESEARCH ,CARDIAC hypertrophy ,MUSCLES ,RESEARCH methodology ,PROGNOSIS ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,ELECTROCARDIOGRAPHY ,HEART failure ,DISEASE complications - Abstract
Aims: To identify independent electrocardiogram (ECG) predictors of long-term clinical outcome based on standardized analysis of the surface ECG in a large multicentre cohort of patients with sarcomeric hypertrophic cardiomyopathy (HCM).Methods and Results: Retrospective observational study from the REMY French HCM clinical research observatory. Primary endpoint was a composite of all-cause mortality, major non-fatal arrhythmic events, hospitalization for heart failure (HF), and stroke. Secondary endpoints were components of the primary endpoint. Uni- and multivariable Cox proportional hazard regression analysis was performed to identify independent predictors. Among 994 patients with HCM, only 1.8% had a strictly normal baseline ECG. The most prevalent abnormalities were inverted T waves (63.7%), P-wave abnormalities (30.4%), and abnormal Q waves (25.5%). During a mean follow-up of 4.0 ± 2.0 years, a total of 272 major cardiovascular events occurred in 217 patients (21.8%): death or heart transplant in 98 (9.8%), major arrhythmic events in 40 (4.0%), HF hospitalization in 115 (11.6%), and stroke in 23 (2.3%). At multivariable analysis using ECG covariates, prolonged QTc interval, low QRS voltage, and PVCs of right bundle branch block pattern predicted worse outcome, but none remained independently associated with the primary endpoint after adjustment on main demographic and clinical variables. For secondary endpoints, abnormal Q waves independently predicted all-cause death [hazard ratio (HR) 2.35, 95% confidence interval (CI) 1.23-4.47; P = 0.009] and prolonged QTc the risk of HF hospitalization (HR 1.006, 95% CI 1.001-1.011; P = 0.024).Conclusion: The 12-lead surface ECG has no independent value to predict the primary outcome measure in patients with HCM. The 12-lead surface ECG has been widely used as a screening tool in HCM but its prognostic value remains poorly known. The value of baseline surface ECG to predict long-term clinical outcomes was studied in a cohort of 994 patients with sarcomeric HCM. The surface ECG has no significant additional value to predict outcome in this patient population. [ABSTRACT FROM AUTHOR]- Published
- 2020
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20. Comparative Influences Of Betablockers And Verapamil On Cardiac Outcomes In Hypertrophic Cardiomyopathy.
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Pinto G, Chiarito M, Puscas T, Bacher A, Donal E, Reant P, Condorelli G, and Hagège A
- Abstract
Guidelines recommend betablockers as first line therapy in symptomatic patients with hypertrophic cardiomyopathy and non-dihydropyridine calcium channel blockers, particularly verapamil, as the second line therapy, despite absence of comparison trials between those two drugs. Since deleterious effects of verapamil have been reported in this setting, the present analysis aimed to evaluate the prognostic impact of betablockers and verapamil in a cohort of patients with hypertrophic cardiomyopathy. From a nation-wide cohort of 1434 patients with a diagnosis of hypertrophic cardiomyopathy included in the French prospective observational REgistry of hypertrophic cardioMYopathy (REMY), we retrospectively analysed individuals with sarcomeric hypertrophic cardiomyopathy included in the three largest centers and treated either with betablockers or verapamil. Patients with a cardiac defibrillator or a pacemaker or who underwent a procedure of atrial fibrillation or septal ablation were excluded. The primary endpoint was the composite of cardiovascular death, hospitalization for heart failure and hospitalization for atrial fibrillation. Out of 600 hypertrophic cardiomyopathy patients, 544 (91%) were treated with betablockers and 56 (9%) with verapamil. At inclusion, the two groups were comparable concerning presence/amplitude of obstruction and sudden cardiac death risk factors. At up to 8-year follow-up (median 3.9 years, IQR 2.1-5.8) no significant differences were observed in the primary endpoint (132 [24%] vs. 10 [18%] under betablockers or verapamil respectively, HR=1.84, 95% CI=0.94-3.63). In conclusion, in a real-world cohort of low risk patients with hypertrophic cardiomyopathy, verapamil therapy was not associated with a higher incidence of adverse events compared to betablocker therapy., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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21. Impact of Pulmonary Hypertension on Outcomes after Transcatheter Tricuspid Valve Edge-to-Edge Repair.
- Author
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Stolz L, Kresoja KP, von Stein J, Fortmeier V, Koell B, Rottbauer W, Kassar M, Goebel B, Denti P, Achouh P, Rassaf T, Barreiro-Perez M, Boekstegers P, Rück A, Doldi PM, Novotny J, Zdanyte M, Adamo M, Vincent F, Lurz P, von Bardeleben RS, Stocker TJ, Weckbach LT, Wild MG, Besler C, Brunner S, Toggweiler S, Grapsa J, Patterson T, Thiele H, Kister T, Tarantini G, Masiero G, De Carlo M, Sticchi A, Konstandin MH, Van Belle E, Metra M, Geisler T, Estévez-Loureiro R, Luedike P, Karam N, Maisano F, Lauten P, Praz F, Kessler M, Kalbacher D, Rudolph V, Iliadis C, Lurz P, Hausleiter J, Pfister R, Baldus S, Gerçek M, Rudolph F, Ludwig S, Pauschinger C, Schneider LM, Felbel D, Salomon C, Lapp H, Puscas T, Berrebi A, Mahabadi AA, Schindhelm F, Caneiro-Queija B, Echarte JC, Schreieck J, Goldschmied A, Pancaldi E, Tomasoni D, Rousse N, Aghezzaf S, Frey N, Kraus M, Westermann D, Rosch S, Arturi F, Panza A, Mazzola M, and Giannini C
- Abstract
Background: Data regarding the association of pulmonary hypertension (PH) and outcomes in patients undergoing transcatheter tricuspid valve edge-to-edge repair (T-TEER) are scarce., Objectives: To 1) investigate the impact of PH on outcomes after T-TEER and 2) to shed further light into the role of pre- and postcapillary PH in patients undergoing T-TEER for relevant tricuspid regurgitation (TR)., Methods: The study included patients from the EuroTR registry (NCT06307262) who underwent T-TEER for relevant TR from 2016 until 2023 with available invasive evaluation of sPAP using right heart catheterization. Study endpoints were procedural TR reduction, improvement in New York Heart Association (NYHA) function class and a combined endpoint of death or heart failure hospitalization (HFH) at two-years., Results: Among a total of 1230 patients (mean age 78.6 ±7.0 years; 51.4% women) increasing systolic pulmonary artery pressure (sPAP) was independently associated with increasing rates of two-year death or HFH (hazard ratio 1.027, 95% confidence interval 1.003-1.052, p=0.030; median survival follow up 343 (114-645) days). No significant survival differences were observed for patients with pre- vs. postcapillary PH. Sensitivity analysis revealed a sPAP value of 46 mmHg as optimized threshold for prediction of death or HFH. Being observed in 526 patients (42.8%), elevated sPAP > 46 mmHg was associated with more severe heart failure symptoms at baseline and follow-up. Importantly, NYHA functional class and TR severity significantly improved irrespective of PH., Conclusion: PH is an important outcome predictor in patients undergoing T-TEER for relevant TR. In contrast to previous studies, no significant differences were observed for patients with pre- and postcapillary PH in terms of survival free from HFH., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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22. Association of Impaired Left Ventricular Mitral Filling from 4D Flow Cardiac MRI and Prognosis of Hypertrophic Cardiomyopathy.
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Sakhi H, Soulat G, Craiem D, Gencer U, Lamy J, Stipechi V, Puscas T, Hulot JS, Hagege A, and Mousseaux E
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- Male, Humans, Middle Aged, Gadolinium, Magnetic Resonance Imaging, Prognosis, Heart Atria, Contrast Media, Cardiomyopathy, Hypertrophic diagnostic imaging
- Abstract
Purpose To investigate whether the peak early filling rate normalized to the filling volume (PEFR/FV) estimated from four-dimensional (4D) flow cardiac MRI may be used to assess impaired left ventricular (LV) filling and predict clinical outcomes in individuals with hypertrophic cardiomyopathy (HCM). Materials and Methods Cardiac MRI with a 4D flow sequence and late gadolinium enhancement (LGE), as well as echocardiography, was performed in 88 individuals: 44 participants with HCM from a French prospective registry (ClinicalTrials.gov; NCT01091480) and 44 healthy volunteers matched for age and sex. In participants with HCM, a composite primary end point was assessed at follow-up, including unexplained syncope, new-onset atrial fibrillation, hospitalization for congestive heart failure, ischemic stroke, sustained ventricular arrhythmia, septal reduction therapy, and cardiac death. A Cox proportional hazard model was used to analyze associations with the primary end point. Results PEFR/FV was significantly lower in the HCM group (mean age, 51.8 years ± 18.5 [SD]; 29 male participants) compared with healthy volunteers (mean, 3.35 sec
-1 ± 0.99 [0.90-5.20] vs 4.42 sec-1 ± 1.68 [2.74-11.86]; P < .001) and correlated with both B-type natriuretic peptide (BNP) level ( r = -0.31; P < .001) and the ratio of pulsed Doppler early transmitral inflow to Doppler tissue imaging annulus velocities (E/E'; r = -0.54; P < .001). At a median follow-up of 2.3 years (IQR, 1.7-3.3 years), the primary end point occurred in 14 (32%) participants. A PEFR/FV of 2.61 sec-1 or less was significantly associated with occurrence of the primary end point (hazard ratio, 9.46 [95% CI: 2.61, 45.17; P < .001] to 15.21 [95% CI: 3.51, 80.22; P < .001]), independently of age, BNP level, E/E', LGE extent, and LV and left atrial strain according to successive bivariate models. Conclusion In HCM, LV filling evaluated with 4D flow cardiac MRI correlated with Doppler and biologic indexes of diastolic dysfunction and predicted clinical outcomes. Keywords: Diastolic Function, Left Ventricular Filling, Hypertrophic Cardiomyopathy, Cardiac MRI, 4D Flow Sequence Clinical trial registration no. NCT01091480 Supplemental material is available for this article. © RSNA, 2024.- Published
- 2024
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23. Prognostic value of the 12-lead surface electrocardiogram in sarcomeric hypertrophic cardiomyopathy: data from the REMY French register.
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Ledieu N, Larnier L, Auffret V, Marie C, Fargeau D, Donal E, Mirabel M, Jeunemaitre X, Puscas T, Marijon E, Reynaud A, Ritter P, Lafitte S, Mabo P, Réant P, Daubert C, and Hagège AA
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- Electrocardiography, Humans, Prognosis, Retrospective Studies, Risk Factors, Sarcomeres, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic diagnosis, Heart Failure
- Abstract
Aims: To identify independent electrocardiogram (ECG) predictors of long-term clinical outcome based on standardized analysis of the surface ECG in a large multicentre cohort of patients with sarcomeric hypertrophic cardiomyopathy (HCM)., Methods and Results: Retrospective observational study from the REMY French HCM clinical research observatory. Primary endpoint was a composite of all-cause mortality, major non-fatal arrhythmic events, hospitalization for heart failure (HF), and stroke. Secondary endpoints were components of the primary endpoint. Uni- and multivariable Cox proportional hazard regression analysis was performed to identify independent predictors. Among 994 patients with HCM, only 1.8% had a strictly normal baseline ECG. The most prevalent abnormalities were inverted T waves (63.7%), P-wave abnormalities (30.4%), and abnormal Q waves (25.5%). During a mean follow-up of 4.0 ± 2.0 years, a total of 272 major cardiovascular events occurred in 217 patients (21.8%): death or heart transplant in 98 (9.8%), major arrhythmic events in 40 (4.0%), HF hospitalization in 115 (11.6%), and stroke in 23 (2.3%). At multivariable analysis using ECG covariates, prolonged QTc interval, low QRS voltage, and PVCs of right bundle branch block pattern predicted worse outcome, but none remained independently associated with the primary endpoint after adjustment on main demographic and clinical variables. For secondary endpoints, abnormal Q waves independently predicted all-cause death [hazard ratio (HR) 2.35, 95% confidence interval (CI) 1.23-4.47; P = 0.009] and prolonged QTc the risk of HF hospitalization (HR 1.006, 95% CI 1.001-1.011; P = 0.024)., Conclusion: The 12-lead surface ECG has no independent value to predict the primary outcome measure in patients with HCM. The 12-lead surface ECG has been widely used as a screening tool in HCM but its prognostic value remains poorly known. The value of baseline surface ECG to predict long-term clinical outcomes was studied in a cohort of 994 patients with sarcomeric HCM. The surface ECG has no significant additional value to predict outcome in this patient population., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2020
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