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2. Reperfusion therapy in acute ischaemic stroke due to cervical and cerebral artery dissection: Results from a Spanish multicentre study

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Campo-Caballero, D., de la Riva, P., de Arce, A., Martínez-Zabaleta, M., Rodríguez-Antigüedad, J., Ekiza, J., Iruzubieta, P., Purroy, F., Fuentes, B., de Lera Alfonso, M., Krupinski, J., Mengual Chirife, J.J., Palomeras, E., Guisado-Alonso, D., Rodríguez-Yáñez, M., Ustrell, X., Tejada García, J., de Felipe Mimbrera, A., Paré-Curell, M., Tembl, J., Cajaraville, S., Garcés, M., and Serena, J.

Published
2023
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3. Tratamiento de reperfusión en el ictus isquémico agudo por disección arterial cervicocerebral: descripción de los resultados de un estudio nacional multicéntrico

Author

Campo-Caballero, D., de la Riva, P., de Arce, A., Martínez-Zabaleta, M., Rodríguez-Antigüedad, J., Ekiza, J., Iruzubieta, P., Purroy, F., Fuentes, B., de Lera Alfonso, M., Krupinski, J., Mengual Chirife, J.J., Palomeras, E., Guisado-Alonso, D., Rodríguez-Yáñez, M., Ustrell, X., Tejada García, J., de Felipe Mimbrera, A., Paré-Curell, M., Tembl, J., Cajaraville, S., Garcés, M., and Serena, J.

Published
2023
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14. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

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Abdelhamid, N, Abdul Rahman, D, Abdul-Saheb, M, Abreu, P, Abroskina, M, Abu Ahmad, F, Accassat, S, Acciaresi, M, Adami, A, Ahmad, N, Ahmed, F, Alberto Hawkes, M, Alemseged, F, Ali, A, Altavilla, R, Alwis, L, Amarenco, P, Amaro, S, Amaya Sanchez, LE, Amelia Pinto, A, Ameriso, SF, Amin, H, Amino, T, Amjad, AK, Anagnostou, E, Andersen, G, Anderson, C, Anderson, DC, Andrea Falco, M, Andres Mackinnon, F, Andreu, D, Androulakis, M, Angel Gamero, M, Angel Saredo, G, Angeles Diaz, R, Angels Font, M, Anticoli, S, Arauz, A, Arauz Gongora, AA, Araya, P, Arenillas Lara, JF, Arias Rivas, S, Arnold, M, Augustin, S, Avelar, W, Azevedo, E, Babikian, V, Bacellar, A, Badalyan, K, Bae, HJ, Baez Martinez, EM, Bagelmann, H, Bailey, P, Bak, Z, Baker, M, Balazs, A, Baldaranov, D, Balogun, I, Balueva, T, Bankuti, Z, Bar, M, Baranowska, A, Bardutzky, J, Barker Trejo, S, Barlinn, J, Baronnet, F, Barroso, C, Barteys, M, Bartolottiova, T, Barulin, A, Bas, M, Bashir, S, Basile, V, Bathe-Peters, R, Bathula, R, Batista, C, Batur Caglayan, H, Baumgartner, P, Bazan, R, Bazhenova, O, Beaudry, M, Beer, J, Behnam, Y, Beilei, C, Beinlich, A, Bejot, Y, Belkin, A, Benavente, OR, Benjamin, A, Berardi, V, Bereczki, D, Berkowitz, SD, Berlingieri, J, Berrios, W, Berrouschot, J, Bhandari, M, Bhargavah, M, Bicker, H, Bicsak, T, Bilik, M, Bindila, D, Birchenall, J, Birnbaum, L, Black, T, Blacker, D, Blacquiere, D, Blanc-Labarre, C, Blank, C, Blazejewska-Hyzorek, B, Bloch, S, Bodiguel, E, Bogdanov, E, Boos, L, Borcsik, L, Bornstein, N, Bouly, S, Braga, G, Bragado, I, Bravi, MC, Brokalaki, C, Brola, W, Brouns, R, Bruce, D, Brzoska-Mizgalska, J, Buck, B, Buksinska-Lisik, M, Burke, J, Burn, M, Bustamante, G, Cabrejo, L, Cai, K, Cajaraville, S, Calejo, M, Calvet, D, Campillo, J, Campos Costa, E, Camps, P, Can Alaydin, H, Candeloro, E, Canepa, C, Cantu Brito, CG, Cappellari, M, Carcel, C, Cardona Portela, P, Cardoso, F, Carek, M, Carletti, M, Carlos Portilla, J, Caruso, P, Casado-Naranjo, I, Castellini, P, Castro, D, Castro Meira, F, Cavallini, A, Cayuela Caudevilla, N, Cenciarelli, S, Cereda, C, Cerrone, P, Chakrabarti, A, Chaloulos-Iakovidis, P, Chamorro, A, Chandrasena, D, Chang, DI, Che, C, Chembala, J, Chen, J, Chen, Z, Chen, T, Chen, H, Chen, X, Chen, G, Chen, L, Chen, S, Cheripelli, B, Chin, M, Chiquete Anaya, E, Chorazy, M, Christensen, H, Christensen, T, Christian, L, Chu, F, Chung, CS, Clark, W, Clarke, R, Claverie, S, Clemente Agostoni, E, Clissold, B, Coelho, J, Cohen, D, Colakoglu, S, Collas, D, Condurso, R, Connolly, SJ, Consoli, D, Constantin, C, Constantino Silva, AB, Contardo, L, Corlobe, A, Correia, M, Correia, C, Cortijo Garcia, E, Coull, B, Coutts, S, Coveney, S, Cras, P, Crols, R, Crozier, S, Csanyi, A, Csiba, L, Csontos, K, Csuha, R, Cui, L, Cunha, L, Curtze, S, Czerska, M, Czlonkowska, A, Czurko, M, Czuryszkiewicz, M, Dagnino, M, Dai, C, Daineko, A, Dalek, G, Damgaard, D, Danese, A, Dani, K, Danku, V, Dario Toledo, W, Dávalos, A, De Havenon, A, De Keyser, J, De Klippel, N, De La Torre, J, De Pauw, A, De Smedt, A, De Torres, R, De Vries Basson, MM, Dearborn, J, Deganutto, R, Degeorgia, M, Deguchi, I, Del Giudice, A, Delcourt, C, Delgado-Mederos, R, Della Marca, G, Delpont, B, Deltour, S, Demets, DL, Dennis, M, Desai, J, Devine, J, Dhollander, I, Di Mascio, MT, Diaconu, M, Diaz Otero, F, Dietzel, J, Diez-Tejedor, E, Ding, N, Ding, J, Diomedi, M, Dioszeghy, P, Distefano, M, Domigo, V, Dorodnicov, E, Dossi, D, Doubal, F, Druzenko, I, Du, P, Du, J, Duman, T, Duodu, Y, Dutta, D, Dylewicz, L, Eckstein, J, Ehrensperger, E, Ehrlich, S, Einer Allende, G, Elena Halac, B, Elyas, S, Endres, M, Engelbrecht, JM, Engelter, S, Epinat, M, Eren, F, Esbjornsson, M, Escribano, B, Escudero, I, Esisi, B, Essa, B, Esterbauer, M, Evans, N, Eveson, D, Fabio, S, Fang, L, Fanta, S, Fares, M, Fatar, M, Faust, K, Favate, A, Fazekas, F, Federica Denaro, M, Fedin, A, Felipe Amaya, P, Feng, J, Ferencova, K, Fernanda Gilli, M, Fernandez, MD, Fernandez Pirrone, PN, Fernandez Vera, J, Ferrari, J, Ferreira, A, Ferreira Junior, G, Fidler, M, Field, D, Field, T, Figueroa, C, Fiksa, J, Filipov, A, Firstenfeld, A, Fisch, L, Fischer, U, Fisselier, M, Fiszer, U, Fluri, F, Fortea, G, Fotherby, K, Fraczek, A, France, E, Freitas, G, Frey, S, Frick, M, Friedman, A, Friedrich, M, Frisullo, G, Fryze, W, Fuentes Gimeno, B, Fujigasaki, H, Fukuyama, K, Furlan, A, Furlanis, G, Furnace, J, Gabriel, M, Gabriel Reich, E, Gagliardi, RJ, Galati, F, Galli Giqueauk, E, Gallina, A, Gallinella, E, Gallo, J, Gangadharan, S, Gao, Y, Garcia Lopez, R, Garcia Pastor, A, Garcia Sanchez, SM, Garnauf, M, Garnier, P, Gasecki, D, Gasic, K, Gasiorek, K, Gasser, S, Gaugg, M, Gebreyohanns, M, Gebura, K, Geng, J, Geniz Clavijo, M, Georg Haeusler, K, Geran, R, Geremek, M, Gerocs, Z, Ghia, D, Giannandrea, D, Giatsidis, F, Gien Lopez, JA, Gil Nunez, A, Gimenez, L, Giralt, E, Glabinski, A, Gladstone, D, Gliem, M, Gluszkiewicz, M, Goddeau, R, Gogoleva, E, Gokce, M, Goldemund, D, Golikov, K, Gomes Neto, A, Gomez Schneider, M, Gomez-Choco, M, Gomis, M, Gongora-Rivera, JF, Gonysheva, Y, Gonzalez, L, Gonzalez Toledo, ME, Gottschal, M, Gozdzik, I, Grabowski, S, Graf, S, Green, D, Greer, D, Gregorio, T, Greisenegger, S, Greshnova, I, Griebe, M, Grzesik, M, Guan, J, Guarda, S, Gueguen, A, Guidoux, C, Guillermo Povedano, P, Guillon, B, Guiraudg, V, Gunathilagan, G, Guryanova, N, Gusev, V, Gustavo Persi, G, Gutiérrez, R, Guyler, P, Gyuker, N, Hachinski, V, Hajas, A, Hallevi, H, Hankey, G, Hankey, GJ, Hanouskova, L, Hao, L, Haraguchi, K, Haralur Sreekantaiah, Y, Haratz, S, Hargroves, D, Harkness, K, Harmel, P, Harrasser, M, Hart, RG, Harvey, M, Hasan, R, Hasegawa, Y, Hassan, A, Hattori, M, Hatzitolios, A, Hauk, M, Hayashi, T, Hayhoe, H, Hedna, VS, Heine, M, Held, V, Hellwig, S, Henkner, J, Henninger, N, Hermans, S, Hernandez, J, Herrero, D, Hervieu-Begue, M, Herzig, R, Hicken, L, Hieber, M, Hill, M, Hirose, M, Hobeanu, MC, Hobson, B, Hochstetter, M, Hoe Heo, J, Hoffmann, M, Holmstedt, C, Hon, P, Hong, KS, Honma, Y, Horev, A, Horgan, G, Horvath, L, Horvath, M, Hoyer, C, Huang, D, Huang, H, Huber, B, Huhtakangas, J, Hussain, M, Igarashi, S, Iglesias Mohedano, AM, Ignacio Tembl, J, Impellizzeri, M, Inanc, Y, Ioli, P, Irina Aniculaesei, A, Ishida, K, Itabashi, R, Iversen, H, Jagolino, A, Jakab, K, Jander, S, Janka, H, Jankovych, J, Jansen, J, Jasek, L, Javier Alet, M, Javor, L, Jin, X, Jing, P, Joachim, B, Joan Macleod, M, Johnson, M, Jose Martin, J, Joyner, C, Judit Szabo, K, Jun-Oconnell, A, Jura, R, Kaczorowska, B, Kadlcikova, J, Kahles, T, Kakaletsis, N, Kakuk, I, Kalinowska, K, Kaminska, K, Kaneko, C, Kanellos, I, Kapeller, P, Kapica-Topczewska, K, Karasz, O, Karlinski, M, Karlsson, JE, Kasa, K, Kashaeva, E, Kasner, SE, Kaste, M, Kasza, J, Katalin Iljicsov, A, Katsurayama, M, Kaur, S, Kawanishi, M, Kaygorodtseva, S, Ke, K, Kei, A, Keilitz, J, Kellner, J, Kelly, P, Kelly, S, Kemlink, D, Kerekgyarto, M, Keskinarkaus, I, Khairutdinova, D, Khanna, A, Khaw, A, Kholopov, M, Khoumri, C, Kirpicheva, S, Kirshner, H, Kitagawa, K, Kittner, S, Kivioja, R, Klein, F, Kleindorfer, D, Kleinig, T, Klivenyi, P, Knecht, S, Kobayashi, Y, Kobayashi, A, Koch, M, Koehler, L, Koivu, M, Kolianov, V, Koltsov, I, Kondo, T, Konkov, I, Kopecky, S, Korompoki, E, Korpela, J, Kosarz-Lanczek, K, Koutroubi, A, Kovacs, K, Kovacs, T, Kovacs, H, Kowalczyk, K, Kowalska, M, Krajickova, D, Kral, M, Krarup Hansen, C, Kraska, J, Krebs, S, Krejci, V, Kremer, C, Kreuzpointer, R, Krzyzanowska, M, Kucken, D, Kulakowska, A, Kunzmann, J, Kurenkova, N, Kuris, A, Kurkowska-Jastrzebska, I, Kurtenkova, N, Kurushina, O, Kusnick, G, Kustova, M, Kuwashiro, T, Kwan Cha, J, Lago, A, Lagutenko, M, Lajos, B, Lambeck, J, Lamy, C, Landolfi, A, Lanfranconi, S, Lang, W, Lara Lezama, LB, Lara Rodriguez, B, Largo, T, Lasek-Bal, A, Latte, L, Lauer, V, Lavados, P, Le Bouc, R, Leal Cantu, R, Lechner, H, Lecouturier, K, Leder, S, Lee, J, Lee, BC, Leger, A, Leira, E, Leisse, I, Leker, R, Lembo, G, Lenskaya, L, Leyden, J, Li, G, Li, M, Li, S, Li, J, Liamis, G, Liang, H, Liang, Z, Ligot, N, Lin, H, Lindert, R, Lindgren, A, Linna, M, Litwin, T, Liu, K, Liu, X, Llull, L, Lohninger, B, Longoni, M, Loomis, C, Lopes, D, Lopez Fernandez, M, Lopez Garza, N, Lord, A, Louw, S, Lovasz, R, Lowenkopf, T, Lu, Z, Lubke-Detring, SC, Luder, R, Lujan, S, Luo, B, Lupinogina, L, Luschin, G, Lutsep, H, Lvova, A, Ly, J, Grosse, G.M., Ma, H, Ma, C, Machado, M, Machado, C, Macher, S, Machetanz, J, Macian-Montoro, F, Mackey, E, Mackey, A, Maclean, G, Maestre-Moreno, J, Magadan, A, Magyar, T, Mahagney, A, Majid, A, Majjhoo, A, Makaritsis, K, Mandzia, J, Mangas Guijarro, M, Mangion, D, Manios, E, Mann, S, Manning, L, Manno, C, Manuel Garcia, J, Maqueda, V, Mar Castellanos, M, Mar Freijo, M, Marando, C, Marcela Lepera, S, Marcos Couto, J, Maria Bruera, G, Maria Greco, L, Maria Lorenzo, A, Maria Obmann, S, Maria Roa, A, Marini, C, Marinkovic, I, Mario Sumay, G, Mario Torres, C, Marko, M, Markova, S, Markus, H, Marsh, R, Marsili, E, Marta Esnaola, M, Marta Moreno, J, Marti-Fabregas, J, Martina Angelocola, S, Martínez Sánchez, P, Martinez-Majander, N, Martins, S, Marzelik, O, Mastrocola, S, Matamala, G, Matoltsy, A, Matosevic, B, Matsumoto, S, Maud, A, Mauri Cabdevila, G, May, Z, Mayasi, Y, Mayr, A, Mazzoli, T, Mcarthur, K, Mccullough, L, Medina Pech, CE, Medlin, F, Mehdiratta, M, Mehta, S, Mehta, D, Mehta, B, Melis, M, Melnikova, E, Mendez, B, Mendonca, T, Mengual Chirifie, JJ, Menon, N, Mensch, A, Meseguer, E, Messe, S, Metcalf, K, Meyer, N, Michas, F, Micheletti, N, Mikulik, R, Milionis, H, Miller, B, Milling, T, Minelli, C, Minhas, J, Minns, M, Mircea, D, Mishra, S, Mismas, A, Mistri, A, Mitrovic, N, Miyake, H, Modrau, B, Moey, A, Molina, C, Molina, J, Molis, A, Moller, J, Molnar, S, Moniche, F, Monosi, C, Monzani, V, Moonis, M, Morais, R, Morales, L, Morales, A, Morar-Precup, D, Moreton, F, Moro, C, Morozova, E, Morton, M, Morvan, T, Morvan, E, Motko, T, Mowla, A, Mozhejko, E, Muddegowda, G, Mudhar, O, Mueller, T, Muhl, C, Muir, KW, Mundl, H, Munoz, S, Murphy, C, Murphy, S, Murtuzova, A, Musuka, T, Mutzenbach, J, Myint, M, Mysliwy, W, Naccarato, M, Naeije, G, Nagakane, Y, Natarajan, I, Navaratnam, D, Nave, A, Nazliel, B, Nedeltchev, K, Nel, J, Nell, H, Nemeth, R, Nemeth, L, Neto, O, Ng, K, Ngeh, J, Nicolas Chialvo, L, Nieminen, T, Nikkanen, M, Nikl, J, Nikoforova, M, Nishino, S, Nishiyama, Y, Njovane, X, Nogawa, S, Nombela, F, Norrving, B, Nosek, K, Nowak, B, Nowakowska-Sledz, E, Ntaios, G, Numminen, H, Nunez, F, Obadia, M, Oberndorfer, S, Obrezan, A, Ochiai, J, Oczkowski, W, O'Donnell, MJ, Odyniec, A, Oh, K, Ohira, M, Okamoto, Y, Okpala, M, Okubo, S, Olah, L, Olavarria, V, Oleszek, J, Onat Demirci, N, Ondar, V, Ongun, G, Ooyama, K, Orosz, V, Ortiz, R, Osseby, G, Österlund-Tauriala, E, Ovesen, C, Ozcekic Demirhan, S, Ozdoba-Rot, J, Ozturk, S, Ozyurt, E, Pablo Grecco, M, Pablo Povedano, G, Paciaroni, M, Padiglioni, C, Pagola, J, Palasik, W, Panczel, G, Panos, L, Papadopoulos, G, Papadopoulou, E, Papagiannis, A, Papavasileiou, V, Papina, M, Pardo De Donlebun, JR, Parisi, V, Park, JM, Pasten, J, Patel, N, Pavlik, O, Pawelczyk, M, Peacock, WF, Pei, H, Peisker, T, Pena Sedna, LF, Penn, A, Pentek, S, Pepper, E, Pereira, L, Perera, K, Perez, Y, Perez, S, Perez Leguizamon, P, Pernicka, M, Perry, R, Persico, A, Pesant, Y, Peska, S, Peters, D, Peters, G, Pettigrew, L, Phan, T, Philippi, S, Phinney, T, Pico, F, Pidal, A, Piechowski-Jozwiak, B, Pieroni, A, Pineiro, S, Piras, V, Pizova, N, Polanco, J, Polin, M, Polyakov, A, Polychronopoulou, E, Polymeris, A, Popov, D, Poppe, A, Postorino, P, Pozzerese, C, Pradhan, M, Prats, L, Prazdnichkova, E, Prendl, B, Pretorius, M, Profice, P, Prokopenko, S, Pudov, E, Pujol Lereis, V, Punzo Bravo, G, Purroy, F, Qiu, J, Qu, X, Quenardelle, V, Quesada Garcia, H, Radrizzani, L, Radtke, A, Raffelsberger, T, Ramirez Moreno, JM, Ramos-Estebanez, C, Rani, A, Rapantova, P, Rashed, K, Rasheed Nihara, A, Rasmussen, J, Redondo Robles, L, Reif, M, Reiner, P, Rekova, P, Renu, A, Repetto, M, Reyes, P, Reyes Morales, S, Rha, JH, Ribeiro, J, Ricci, S, Richard, C, Rigual, R, Rinaldi, C, Riveira Rodriguez, C, Rizzato, B, Robinson, TG, Rocco, A, Rodrigues, M, Rodriguez, G, Rodriguez Campello, A, Rodriguez Lucci, F, Rodriguez Yanez, M, Roesler, C, Roffe, C, Roine, R, Roine, S, Roldan, A, Romana Pezzella, F, Romano, M, Roos, JS, Rosso, C, Rostrup Kruuse, C, Roth, Y, Roukens, R, Roveri, L, Rozanski, D, Rozniecki, J, Rozsa, C, Rudilosso, S, Ruiz Ares, G, Ruiz Franco, A, Rum, G, Ruuskanen, J, Rybinnik, I, Ryota, K, Saarinen, J, Saavedra, V, Sabben, C, Sabet, A, Sagris, D, Sahlas, J, Sakai, N, Salamanca, P, Salgado, P, Salig, S, Salletmayr, T, Salnikov, M, Samoshkina, O, Samson, Y, Sanak, D, Sànchez Cerón, M, Santalucia, P, Santamaria Cadavid, M, Santiago, P, Santo, G, Sanz Cuesta, B, Sargento, J, Sarraj, A, Sas, K, Sas, A, Satoshi, O, Satsoglou, S, Sattar, N, Savitz, S, Savopoulos, C, Saw, J, Sawicka, M, Sawyer, R, Scandura, T, Schillinger, N, Schindler, J, Schlachetzki, F, Schneider, I, Schuppner, R, Schurig, J, Schwarzbach, CJ, Sebejova, M, Seidel, G, Sekaran, L, Selcuk, D, Selvarajah, J, Semerano, A, Semjen, J, Semushina, D, Sen, S, Seok Park, M, Serena, J, Serhat Tokgoz, O, Serles, W, Serrano, F, Sevin, M, Seynaeve, L, Shah, S, Shamalov, N, Shang, T, Sharma, M, Sharrief, A, Shazam Hussain, M, Shchukin, I, Shen, W, Shepeleva, E, Shinsuke, I, Shmonin, A, Shoamanesh, A, Shuaib, A, Shulga, A, Sibolt, G, Sibon, I, Sicilia, I, Siebert, M, Sieczkowska, E, Sila, C, Silva, AA, Silva, D, Silva, P, Silva, Y, Silvestrini, M, Simony, Z, Simpkins, A, Singh, B, Sinha, D, Sipos, I, Skoda, O, Skowron, P, Skowronska, M, Sliwinska, B, Slonkova, J, Smolkin, A, Smyth, A, Sobolewski, P, Sobota, A, Sohn, SI, Soldatov, M, Solganov, I, Soloveva, L, Solovyeva, E, Sonntag, N, Soors, P, Sorgun, M, Soriano, C, Spence, D, Spengos, K, Sposato, L, Staaf, G, Stadler, K, Stakhovskaya, L, Stamatelopoulos, K, Steinert, S, Stetkarova, I, Stiehm, M, Stocker, R, Stoinski, J, Stoll, A, Stotts, G, Stumpp, A, Sucapane, P, Suenaga, T, Sun, X, Sundararajan, S, Sung Kim, J, Suzuki, H, Svaneborg, N, Szasz, G, Szczuchniak, W, Szczyrba, S, Szegedi, N, Szekely, A, Szewczyk, Z, Szilagyi, G, Szlufik, S, Szoboszlai, K, Szpisjak, L, Sztajzel, R, Sztriha, L, Ta Wil, SE, Taggeselle, J, Takamatsu, K, Takao, M, Taki, W, Takizawa, S, Talahma, M, Tamayo, A, Tan, J, Tanne, D, Tapanainen, A, Tapiola, T, Tarasiuk, J, Tatlisumak, T, Tayal, A, Tcvetkova, S, Teal, P, Tejada Garcia, J, Tejada Meza, H, Tenora, D, Terceno, M, Terentiou, A, Tezcan, S, Thaler, D, Thomson, A, Thouvenot, E, Tiainen, M, Timberg, I, Timsit, S, Tinchon, A, Tirschwell, D, Togay Isikay, C, Tokunaga, K, Tolino, M, Toloza, C, Tomelleri, G, Tomoyuki, K, Tomppo, LM, Tong, Z, Tong, L, Toni, D, Torres, J, Tossavainen, C, Toth, G, Tountopoulou, A, Touze, E, Tovar, M, Toyoda, K, Trillo, S, Trommer, A, Tropepi, D, Tryambake, D, Tu, H, Tuetuencue, S, Tumova, R, Tumpula, O, Turc, G, Tutaj, A, Tynkkynen, J, Uchiyama, S, Uchwat, U, Uhrinyakova, L, Ulku Acar, R, Uluduz Ugurlu, D, Urra, X, Urui, S, Usero Ruiz, M, Vaclavik, D, Vahedi, K, Valikovics, A, Valpas, J, Van Acker, P, Van Daele, W, Vanderschueren, G, Vanina Jure, L, Varela, R, Varga, Z, Varvat, J, Varvyanskaya, N, Vasco Salgado, A, Vasko, P, Vass, L, Vassilopoulou, S, Vastagh, I, Vazquez, P, Vecsei, L, Veltkamp, R, Venti, M, Verdugo, M, Verocai, V, Veronica Marroquin, M, Veronica Simonsini, C, Veverka, T, Vigl, M, Vila, A, Vilar, C, Villanueva Osorio, JA, Virta, J, Vitkova, E, Voglsperger, B, Volna, J, Von Weitzel-Mudersbach, PA, Vora, N, Voznyuk, I, Wach-Klink, A, Wacongne, A, Walters, D, Wang, Y, Wang, J, Wang, L, Wang, X, Wang, W, Wang, N, Wang, D, Wang, H, Warnack, W, Wartenberg, K, Waters, R, Waters, M, Webb, T, Weber, J, Weiss, G, Weissenborn, K, Weitz, JI, Weller, B, Wen, G, Weng, G, Werner, P, Werring, D, Wester, P, Whiteley, W, Whiting, R, Wijeratne, T, Willems, C, Wilson, L, Wilson, C, Winder, T, Windt, J, Winkler, A, Winska-Tereszkiewicz, A, Wisniewska, A, Wittayer, M, Wlodek, A, Wojnarowska-Arendt, A, Wolf, M, Wolff, V, Wolter, C, Wong, A, Wook Nah, H, Worthmann, H, Wu, W, Wu, S, Wunderlich, S, Wurzinger, H, Wyse, DG, Xiao, B, Xiaopeng, W, Ximenez-Carrillo, A, Xiong, L, Xiong, Y, Xiong, W, Xu, Y, Xu, J, Xu, Z, Yalo, B, Yamada, T, Yamasaki, M, Yang, L, Yang, Y, Yang, X, Yang, Q, Yang, B, Yang, J, Yasuhiro, I, Yee Lam, M, Yegappan, C, Yip, S, Ylikallio, E, Ylikotila, P, Yongwon Jin, A, Yoon, BW, Yoshida, Y, Yperzeele, L, Yuan, H, Yuasa, H, Zalewska, J, Zanferrari, C, Zapata, E, Zboznovits, D, Zelenka, I, Zhang, C, Zhang, B, Zhang, S, Zhang, M, Zhang, X, Zhang, J, Zhao, L, Zhirnova, O, Zhou, L, Zielinska-Turek, J, Zinchenko, I, Ziomek, M, Zitzmann, A, Zweifler, R, Zwiernik, J, Kasner, Scott E, Swaminathan, Balakumar, Lavados, Pablo, Sharma, Mukul, Muir, Keith, Veltkamp, Roland, Ameriso, Sebastian F, Endres, Matthias, Lutsep, Helmi, Messé, Steven R, Spence, J David, Nedeltechev, Krassen, Perera, Kanjana, Santo, Gustavo, Olavarria, Veronica, Lindgren, Arne, Bangdiwala, Shrikant, Shoamanesh, Ashkan, Berkowitz, Scott D, Mundl, Hardi, Connolly, Stuart J, and Hart, Robert G

Published
2018
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15. Prehospital scale to differentiate intracerebral hemorrhage from large-vessel occlusion patients: A prospective cohort study

Author

Freixa-Cruz, A, primary, Jimenez-Jimenez, G, additional, Mauri-Capdevila, G, additional, Gallego-Sánchez, Y, additional, García-Díaz, A, additional, Mitjana Penella, R, additional, Paul-Arias, M, additional, Pereira-Priego, C, additional, Ruiz-Fernández, E, additional, Salvany-Montserrat, S, additional, Sancho-Saldaña, A, additional, San-Pedro-Murillo, E, additional, Saureu, E, additional, Vázquez-Justes, D, additional, and Purroy, F, additional

Published
2023
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16. Prognostic factors and analysis of mortality due to brain haemorrhages associated with vitamin K antagonist oral anticoagulants. Results from the TAC Registry

Author

Zapata-Wainberg, G., Quintas, S., Ximénez-Carrillo Rico, A., Benavente Fernández, L., Masjuan Vallejo, J., Gállego Culleré, J., Freijó Guerrero, M. del M., Egido, J., Gómez Sánchez, J.C., Martínez Domeño, A., Purroy, F., Vives Pastor, B., Rodríguez Yáñez, M., and Vivancos, J.

Published
2018
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17. Factores pronósticos y análisis de la mortalidad de las hemorragias cerebrales asociadas a anticoagulantes orales antagonistas de la vitamina K. Resultados del Estudio TAC Registry

Author

Zapata-Wainberg, G., Quintas, S., Ximénez-Carrillo Rico, A., Benavente Fernández, L., Masjuan Vallejo, J., Gállego Culleré, J., Freijó Guerrero, M. del M., Egido, J., Gómez Sánchez, J.C., Martínez Domeño, A., Purroy, F., Vives Pastor, B., Rodríguez Yáñez, M., and Vivancos, J.

Published
2018
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19. Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia

Author

Silva, Y, Sánchez-Cirera, L, Terceño, M, Dorado, L, Valls, A, Martínez, M, Abilleira, S, Rubiera, M, Quesada, H, Llull, L, Rodríguez-Campello, A, Martí-Fàbregas, J, Seró, L, Purroy, F, Payo, I, García, S, Cánovas, D, Krupinski, J, Mas, N, Palomeras, E, Cocho, D, Font, MÀ, Catena, E, Puiggròs, E, Pedroza, C, Marín, G, Carrión, D, Costa, X, Almendros, MC, Torres, I, Colom, C, Velasquez, JA, Diaz, G, Jiménez, X, Subirats, T, Deulofeu, A, Hidalgo, V, Salvat-Plana, M, Pérez de la Ossa, N, Silva, Y, Sánchez-Cirera, L, Terceño, M, Dorado, L, Valls, A, Martínez, M, Abilleira, S, Rubiera, M, Quesada, H, Llull, L, Rodríguez-Campello, A, Martí-Fàbregas, J, Seró, L, Purroy, F, Payo, I, García, S, Cánovas, D, Krupinski, J, Mas, N, Palomeras, E, Cocho, D, Font, MÀ, Catena, E, Puiggròs, E, Pedroza, C, Marín, G, Carrión, D, Costa, X, Almendros, MC, Torres, I, Colom, C, Velasquez, JA, Diaz, G, Jiménez, X, Subirats, T, Deulofeu, A, Hidalgo, V, Salvat-Plana, M, and Pérez de la Ossa, N

Abstract

Introduction: Previous studies have reported differences in the management and outcome of women stroke patients in comparison with men. We aim to analyze sex and gender differences in the medical assistance, access to treatment and outcome of acute stroke patients in Catalonia. Patients and methods: Data were obtained from a prospective population-based registry of stroke code activations in Catalonia (CICAT) from January/2016 to December/2019. The registry includes demographic data, stroke severity, stroke subtype, reperfusion therapy, and time workflow. Centralized clinical outcome at 90 days was assessed in patients receiving reperfusion therapy. Results: A total of 23,371 stroke code activations were registered (54% men, 46% women). No differences in prehospital time metrics were observed. Women more frequently had a final diagnosis of stroke mimic, were older and had a previous worse functional situation. Among ischemic stroke patients, women had higher stroke severity and more frequently presented proximal large vessel occlusion. Women received more frequently reperfusion therapy (48.2% vs 43.1%, p < 0.001). Women tended to present a worse outcome at 90 days, especially for the group receiving only IVT (good outcome 56.7% vs 63.8%; p < 0.001), but not for the group of patients treated with IVT + MT or MT alone, although sex was not independently associated with clinical outcome in logistic regression analysis (OR 1.07; 95% CI, 0.94–1.23; p = 0.27) nor in the analysis after matching using the propensity score (OR 1.09; 95% CI, 0.97–1.22). Discussion and conclusion: We found some differences by sex in that acute stroke was more frequent in older women and the stroke severity was higher. We found no differences in medical assistance times, access to reperfusion treatment and early complications. Worse clinical outcome at 90 days in women was conditioned by stroke severity and older age, but not by sex itself.

Published
2023

22. Clinical management guidelines for subarachnoid haemorrhage. Diagnosis and treatment

Author

Vivancos, J., Gilo, F., Frutos, R., Maestre, J., García-Pastor, A., Quintana, F., Roda, J.M., Ximénez-Carrillo, A., Díez Tejedor, E., Fuentes, B., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., Fernández, J.C., Freijo, M., Gállego, J., Gil-Núñez, A., Irimia, P., Lago, A., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Morales, A., Nombela, F., Purroy, F., Ribó, M., Rodríguez-Yañez, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Simal, P., and Tejada, J.

Published
2014
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23. Guía de actuación clínica en la hemorragia subaracnoidea. Sistemática diagnóstica y tratamiento

Author

Vivancos, J., Gilo, F., Frutos, R., Maestre, J., García-Pastor, A., Quintana, F., Roda, J.M., Ximénez-Carrillo, A., Díez Tejedor, E., Fuentes, B., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., Fernández, J.C., Freijo, M., Gállego, J., Gil-Núñez, A., Irimia, P., Lago, A., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Morales, A., Nombela, F., Purroy, F., Ribó, M., Rodríguez-Yañez, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Simal, P., and Tejada, J.

Published
2014
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26. Guía para el tratamiento preventivo del ictus isquémico y AIT (II). Recomendaciones según subtipo etiológico

Author

Fuentes, B., Gállego, J., Gil-Nuñez, A., Morales, A., Purroy, F., Roquer, J., Segura, T., Tejada, J., Lago, A., Díez-Tejedor, E., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., López-Fernández, J.C., Freijo, M., García Pastor, A., Gilo, F., Irimia, P., Maestre, J., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Nombela, F., Ribó, M., Rodríguez-Yañez, M., Rubio, F., Serena, J., Simal, P., and Vivancos, J.

Published
2014
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27. Guidelines for the treatment of acute ischaemic stroke

Author

Alonso de Leciñana, M., Egido, J.A., Casado, I., Ribó, M., Dávalos, A., Masjuan, J., Caniego, J.L., Martínez Vila, E., Díez Tejedor, E., Fuentes (Secretaría), B., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Castellanos, M., Castillo, J., Díaz-Otero, F., López-Fernández, J.C., Freijo, M., Gállego, J., García-Pastor, A., Gil-Núñez, A., Gilo, F., Irimia, P., Lago, A., Maestre, J., Martí-Fábregas, J., Martínez-Sánchez, P., Molina, C., Morales, A., Nombela, F., Purroy, F., Rodríguez-Yañez, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Simal, P., Tejada, J., and Vivancos, J.

Published
2014
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28. Guía para el tratamiento del infarto cerebral agudo

Author

Alonso de Leciñana, M., Egido, J.A., Casado, I., Ribó, M., Dávalos, A., Masjuan, J., Caniego, J.L., Martínez Vila, E., Díez Tejedor, E., Fuentes (Secretaría), B., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Castellanos, M., Castillo, J., Díaz-Otero, F., López-Fernández, J.C., Freijo, M., Gállego, J., García-Pastor, A., Gil-Núñez, A., Gilo, F., Irimia, P., Lago, A., Maestre, J., Martí-Fábregas, J., Martínez-Sánchez, P., Molina, C., Morales, A., Nombela, F., Purroy, F., Rodríguez-Yañez, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Simal, P., Tejada, J., and Vivancos, J.

Published
2014
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29. Reperfusion therapy in acute ischaemic stroke due to cervical and cerebral artery dissection: Results from a Spanish multicentre study

Author

Campo-Caballero, D., primary, de la Riva, P., additional, de Arce, A., additional, Martínez-Zabaleta, M., additional, Rodríguez-Antigüedad, J., additional, Ekiza, J., additional, Iruzubieta, P., additional, Purroy, F., additional, Fuentes, B., additional, de Lera Alfonso, M., additional, Krupinski, J., additional, Mengual Chirife, J.J., additional, Palomeras, E., additional, Guisado-Alonso, D., additional, Rodríguez-Yáñez, M., additional, Ustrell, X., additional, Tejada García, J., additional, de Felipe Mimbrera, A., additional, Paré-Curell, M., additional, Tembl, J., additional, Cajaraville, S., additional, Garcés, M., additional, and Serena, J., additional

Published
2022
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31. Clinical practice guidelines in intracerebral haemorrhage

Author

Rodríguez-Yáñez, M., Castellanos, M., Freijo, M.M., López Fernández, J.C., Martí-Fàbregas, J., Nombela, F., Simal, P., Castillo, J., Díez-Tejedor, E., Fuentes, B., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Dávalos, A., Díaz-Otero, F., Egido, J.A., Gállego, J., García Pastor, A., Gil-Núñez, A., Gilo, F., Irimia, P., Lago, A., Maestre, J., Masjuan, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Morales, A., Purroy, F., Ribó, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Tejada, J., and Vivancos, J.

Published
2013
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32. Guías de actuación clínica en la hemorragia intracerebral

Author

Rodríguez-Yáñez, M., Castellanos, M., Freijo, M.M., López Fernández, J.C., Martí-Fàbregas, J., Nombela, F., Simal, P., Castillo, J., Díez-Tejedor, E., Fuentes, B., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Dávalos, A., Díaz-Otero, F., Egido, J.A., Gállego, J., García Pastor, A., Gil-Núñez, A., Gilo, F., Irimia, P., Lago, A., Maestre, J., Masjuan, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Morales, A., Purroy, F., Ribó, M., Roquer, J., Rubio, F., Segura, T., Serena, J., Tejada, J., and Vivancos, J.

Published
2013
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33. Workflow times and outcomes in patients triaged for a suspected severe stroke

Author

García-Tornel, Á, Seró, L, Urra, X, Cardona, P, Zaragoza, J, Krupinski, J, Gómez-Choco, M, Sala, NM, Catena, E, Palomeras, E, Serena, J, Hernandez-Perez, M, Boned, S, Olivé-Gadea, M, Requena, M, Muchada, M, Tomasello, A, Molina, CA, Salvat-Plana, M, Escudero, M, Jimenez, X, Davalos, A, Jovin, TG, Purroy, F, Abilleira, S, Ribo, M, de la Ossa, NP, García-Tornel, Á, Seró, L, Urra, X, Cardona, P, Zaragoza, J, Krupinski, J, Gómez-Choco, M, Sala, NM, Catena, E, Palomeras, E, Serena, J, Hernandez-Perez, M, Boned, S, Olivé-Gadea, M, Requena, M, Muchada, M, Tomasello, A, Molina, CA, Salvat-Plana, M, Escudero, M, Jimenez, X, Davalos, A, Jovin, TG, Purroy, F, Abilleira, S, Ribo, M, and de la Ossa, NP

Abstract

Introduction: Current recommendations for regional stroke destination suggest that patients with severe acute stroke in non-urban areas should be triaged based on the estimated transport time to a referral thrombectomy-capable center. Methods: We performed a post hoc analysis to evaluate the association of pre-hospital workflow times with neurological outcomes in patients included in the RACECAT trial. Workflow times evaluated were known or could be estimated before transport allocation. Primary outcome was the shift analysis on the modified Rankin score at 90 days. Results: Among the 1,369 patients included, the median time from onset to emergency medical service (EMS) evaluation, the estimated transport time to a thrombectomy-capable center and local stroke center, and the estimated transfer time between centers were 65 minutes (interquartile ratio [IQR] = 43–138), 61 minutes (IQR = 36–80), 17 minutes (IQR = 9–27), and 62 minutes (IQR = 36–73), respectively. Longer time intervals from stroke onset to EMS evaluation were associated with higher odds of disability at 90 days in the local stroke center group (adjusted common odds ratio (acOR) for each 30-minute increment = 1.03, 95% confidence interval [CI] = 1.01–1.06), with no association in the thrombectomy-capable center group (acOR for each 30-minute increment = 1.01, 95% CI = 0.98–1.01, pinteraction = 0.021). No significant interaction was found for other pre-hospital workflow times. In patients evaluated by EMS later than 120 minutes after stroke onset, direct transport to a thrombectomy-capable center was associated with better disability outcomes (acOR = 1.49, 95% CI = 1.03–2.17). Conclusion: We found a significant heterogeneity in the association between initial transport destination and neurological outcomes according to the elapse of time between the stroke onset and the EMS evaluation (ClinicalTrials.gov: NCT02795962). ANN NEUROL 2022;92:931–942.

Published
2022

34. Outcomes After Direct Thrombectomy or Combined Intravenous and Endovascular Treatment Are Not Different

Author

Abilleira, Sònia, Ribera, Aida, Cardona, Pedro, Rubiera, Marta, López-Cancio, Elena, Amaro, Sergi, Rodríguez-Campello, Ana, Camps-Renom, Pol, Cánovas, David, de Miquel, Maria Angels, Tomasello, Alejandro, Remollo, Sebastian, López-Rueda, Antonio, Vivas, Elio, Perendreu, Joan, Gallofré, Miquel, Martí-Fàbregas, J., Delgado-Mederos, R., Martínez-Domeño, A., Marín, R., Roquer, J., Ois, Á., Jiménez-Conde, J., Guimaraens, L., Chamorro, Á., Obach, V., Urra, X., Macho, J.M., Blasco, J., San Roman, L., Martínez-Yélamos, A., Quesada, H., Lara, B, Cayuela, N., Aja, L., Mora, P., Molina, C., Ribó, M., Pagola, J., Rodríguez-Luna, D., Muchada, M., Coscojuela, P., Dávalos, A., Millán, M., Pérez de la Ossa, N., Gomis, M., Dorado, L., Castaño, C., Garcia, M.C., Estela, J., Krupinski, J., Huertas-Folch, S., Nicolás-Herrerias, M.C., Gómez-Choco, M., García, S., Martínez, R., Sanahuja, J., Purroy, F., Serena, J., Castellanos, M., Silva, Y., Marés, R., Pellisé, A., Ustrell, X., Baiges, J.J., Garcés, M., Saura, J., Soler-Insa, J.M., Aragonés, J.M., Cocho, D., and Palomeras, E.

Published
2017
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35. Guidelines for the preventive treatment of ischaemic stroke and TIA (I). Update on risk factors and life style

Author

Fuentes, B., Gállego, J., Gil-Nuñez, A., Morales, A., Purroy, F., Roquer, J., Segura, T., Tejada, J., Lago, A., Díez-Tejedor, E., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., López-Fernández, J.C., Freijo, M., García Pastor, A., Gilo, F., Irimia, P., Maestre, J., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Nombela, F., Ribó, M., Rodríguez-Yañez, M., Rubio, F., Serena, J., Simal, P., and Vivancos, J.

Published
2012
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36. Guía para el tratamiento preventivo del ictus isquémico y AIT (I). Actuación sobre los factores de riesgo y estilo de vida

Author

Fuentes, B., Gállego, J., Gil-Nuñez, A., Morales, A., Purroy, F., Roquer, J., Segura, T., Tejada, J., Lago, A., Díez-Tejedor, E., Alonso de Leciñana, M., Álvarez-Sabin, J., Arenillas, J., Calleja, S., Casado, I., Castellanos, M., Castillo, J., Dávalos, A., Díaz-Otero, F., Egido, J.A., López-Fernández, J.C., Freijo, M., García Pastor, A., Gilo, F., Irimia, P., Maestre, J., Masjuan, J., Martí-Fábregas, J., Martínez-Sánchez, P., Martínez-Vila, E., Molina, C., Nombela, F., Ribó, M., Rodríguez-Yañez, M., Rubio, F., Serena, J., Simal, P., and Vivancos, J.

Published
2012
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37. Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas The RACECAT Randomized Clinical Trial

Author

de la Ossa, NP, Abilleira, S, Jovin, TG, Garcia-Tornel, A, Jimenez, X, Urra, X, Cardona, P, Cocho, D, Purroy, F, Serena, J, Manzanera, LS, Vivanco-Hidalgo, RM, Salvat-Plana, M, Chamorro, A, Gallofre, M, Molina, CA, Cobo, E, Davalos, A, and Ribo, M

Abstract

Importance In nonurban areas with limited access to thrombectomy-capable centers, optimal prehospital transport strategies in patients with suspected large-vessel occlusion stroke are unknown. Objective To determine whether, in nonurban areas, direct transport to a thrombectomy-capable center is beneficial compared with transport to the closest local stroke center. Design, Setting, and Participants Multicenter, population-based, cluster-randomized trial including 1401 patients with suspected acute large-vessel occlusion stroke attended by emergency medical services in areas where the closest local stroke center was not capable of performing thrombectomy in Catalonia, Spain, between March 2017 and June 2020. The date of final follow-up was September 2020. Interventions Transportation to a thrombectomy-capable center (n = 688) or the closest local stroke center (n = 713). Main Outcomes and Measures The primary outcome was disability at 90 days based on the modified Rankin Scale (mRS; scores range from 0 [no symptoms] to 6 [death]) in the target population of patients with ischemic stroke. There were 11 secondary outcomes, including rate of intravenous tissue plasminogen activator administration and thrombectomy in the target population and 90-day mortality in the safety population of all randomized patients. Results Enrollment was halted for futility following a second interim analysis. The 1401 enrolled patients were included in the safety analysis, of whom 1369 (98%) consented to participate and were included in the as-randomized analysis (56% men; median age, 75 [IQR, 65-83] years; median National Institutes of Health Stroke Scale score, 17 [IQR, 11-21]); 949 (69%) comprised the target ischemic stroke population included in the primary analysis. For the primary outcome in the target population, median mRS score was 3 (IQR, 2-5) vs 3 (IQR, 2-5) (adjusted common odds ratio [OR], 1.03; 95% CI, 0.82-1.29). Of 11 reported secondary outcomes, 8 showed no significant difference. Compared with patients first transported to local stroke centers, patients directly transported to thrombectomy-capable centers had significantly lower odds of receiving intravenous tissue plasminogen activator (in the target population, 229/482 [47.5%] vs 282/467 [60.4%]; OR, 0.59; 95% CI, 0.45-0.76) and significantly higher odds of receiving thrombectomy (in the target population, 235/482 [48.8%] vs 184/467 [39.4%]; OR, 1.46; 95% CI, 1.13-1.89). Mortality at 90 days in the safety population was not significantly different between groups (188/688 [27.3%] vs 194/713 [27.2%]; adjusted hazard ratio, 0.97; 95% CI, 0.79-1.18). Conclusions and Relevance In nonurban areas in Catalonia, Spain, there was no significant difference in 90-day neurological outcomes between transportation to a local stroke center vs a thrombectomy-capable referral center in patients with suspected large-vessel occlusion stroke. These findings require replication in other settings.

Published
2022

39. Stroke health care plan (ICTUS II. 2010)

Author

Masjuan, J., Álvarez-Sabín, J., Arenillas, J., Calleja, S., Castillo, J., Dávalos, A., Díez Tejedor, E., Freijo, M., Gil-Núñez, A., López Fernández, J.C., Maestre, J.F., Martínez-Vila, E., Morales, A., Purroy, F., Ramírez, J.M., Segura, T., Serena, J., Tejada, J., and Tejero, C.

Published
2011
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40. Plan de asistencia sanitaria al ICTUS II. 2010

Author

Masjuan, J., Álvarez-Sabín, J., Arenillas, J., Calleja, S., Castillo, J., Dávalos, A., Tejedor, E. Díez, Freijo, M., Gil-Núñez, A., Fernández, J.C. López, Maestre, J.F., Martínez-Vila, E., Morales, A., Purroy, F., Ramírez, J.M., Segura, T., Serena, J., Tejada, J., and Tejero, C.

Published
2011
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42. How predictors and patterns of stroke recurrence after a TIA differ during the first year of follow-up

Author

Purroy, F., Jiménez Caballero, P. E., Gorospe, A., Torres, M. J., Álvarez-Sabin, J., Martínez-Sánchez, P., Cánovas, D., Freijo, M., Egido, J. A., Ramírez-Moreno, J. M., Alonso-Arias, A., Rodríguez-Campello, A., Casado-Naranjo, I., Martí-Fàbregas, J., Silva, Y., Cardona, P., Morales, A., García-Pastor, A., Arenillas, J. F., Segura, T., Jiménez, C., and Masjuán, J.

Published
2014
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44. Impact of general anesthesia on posterior circulation large vessel occlusions after endovascular thrombectomy

Author

Terceno, M, Silva, Y, Bashir, S, Vera-Monge, VA, Cardona, P, Molina, C, Chamorro, A, de la Ossa, NP, Hernandez-Perez, M, Werner, M, Camps-Renom, P, Rodriguez-Campello, A, Canovas, D, Purroy, F, and Serena, J

Subjects
large vessel occlusion, posterior circulation stroke, General anesthesia
Abstract

Background The impact of general anesthesia on functional outcome in patients with large vessel occlusion remains unclear. Most studies have focused on anterior circulation large vessel occlusion; however, little is known about the effect of general anesthesia in patients with posterior circulation-large vessel occlusion. Methods We performed a retrospective analysis from the prospective CICAT registry. All patients with posterior circulation-large vessel occlusion-and undergoing endovascular therapy between January 2016 and January 2020 were included. Demographics, baseline characteristics, procedural data, and anesthesia modality (general anesthesia or conscious sedation) were evaluated. The primary outcome was the proportion of patients with good clinical outcome (modified Rankin Scale score of 0-2) at three months. Results 298 patients underwent endovascular treatment with posterior circulation-large vessel occlusion-were included. Age, diabetes mellitus, renal insufficiency, baseline National Institutes of Health Stroke Scale score, puncture to recanalization length, >= 3 device passes, absent of successful recanalization (defined as treatment in cerebral ischemia of 3), and general anesthesia were statistically associated with poor outcome (mRS: 3-6). In the multivariable regression, general anesthesia and >= 3 device passes were independently associated with poor outcome (aOR: 3.11, (95% CI: 1.34-7.2); P = 0.01 and 3.77, (95% CI: 1.29-11.01); P = 0.02, respectively). Patients treated with general anesthesia were less likely to have a good outcome at three months compared to conscious sedation (19.7% vs. 45.1%, P < 0.001). Conclusions In our study population, general anesthesia use is associated with poor clinical outcome in patients with posterior circulation-large vessel occlusion-treated endovascularly.

Published
2021

45. SARS-CoV-2 and Stroke Characteristics: A Report from the Multinational COVID-19 Stroke Study Group

Author

Shahjouei, S. Tsivgoulis, G. Farahmand, G. Koza, E. Mowla, A. Vafaei Sadr, A. Kia, A. Vaghefi Far, A. Mondello, S. Cernigliaro, A. Ranta, A. Punter, M. Khodadadi, F. Naderi, S. Sabra, M. Ramezani, M. Amini Harandi, A. Olulana, O. Chaudhary, D. Lyoubi, A. Campbell, B.C.V. Arenillas, J.F. Bock, D. Montaner, J. Aghayari Sheikh Neshin, S. Aguiar De Sousa, D. Tenser, M.S. Aires, A. Alfonso, M.D.L. Alizada, O. Azevedo, E. Goyal, N. Babaeepour, Z. Banihashemi, G. Bonati, L.H. Cereda, C.W. Chang, J.J. Crnjakovic, M. De Marchis, G.M. Del Sette, M. Ebrahimzadeh, S.A. Farhoudi, M. Gandoglia, I. Goncąlves, B. Griessenauer, C.J. Murat Hanci, M. Katsanos, A.H. Krogias, C. Leker, R.R. Lotman, L. Mai, J. Male, S. Malhotra, K. Malojcic, B. Mesquita, T. Mir Ghasemi, A. Mohamed Aref, H. Mohseni Afshar, Z. Moon, J. Niemelä, M. Rezai Jahromi, B. Nolan, L. Pandhi, A. Park, J.-H. Marto, J.P. Purroy, F. Ranji-Burachaloo, S. Carreira, N.R. Requena, M. Rubiera, M. Sajedi, S.A. Sargento-Freitas, J. Sharma, V.K. Steiner, T. Tempro, K. Turc, G. Ahmadzadeh, Y. Almasi-Dooghaee, M. Assarzadegan, F. Babazadeh, A. Baharvahdat, H. Cardoso, F.B. Dev, A. Ghorbani, M. Hamidi, A. Hasheminejad, Z.S. Hojjat-Anasri Komachali, S. Khorvash, F. Kobeissy, F. Mirkarimi, H. Mohammadi-Vosough, E. Misra, D. Noorian, A.R. Nowrouzi-Sohrabi, P. Paybast, S. Poorsaadat, L. Roozbeh, M. Sabayan, B. Salehizadeh, S. Saberi, A. Sepehrnia, M. Vahabizad, F. Yasuda, T.A. Ghabaee, M. Rahimian, N. Harirchian, M.H. Borhani-Haghighi, A. Azarpazhooh, M.R. Arora, R. Ansari, S. Avula, V. Li, J. Abedi, V. Zand, R.

Abstract

Background and Purpose: Stroke is reported as a consequence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in several reports. However, data are sparse regarding the details of these patients in a multinational and large scale. Methods: We conducted a multinational observational study on features of consecutive acute ischemic stroke, intracranial hemorrhage, and cerebral venous or sinus thrombosis among SARS-CoV-2-infected patients. We further investigated the risk of large vessel occlusion, stroke severity as measured by the National Institutes of Health Stroke Scale, and stroke subtype as measured by the TOAST (Trial of ORG 10172 in Acute Stroke Treatment) criteria among patients with acute ischemic stroke. In addition, we explored the neuroimaging findings, features of patients who were asymptomatic for SARS-CoV-2 infection at stroke onset, and the impact of geographic regions and countries' health expenditure on outcomes. Results: Among the 136 tertiary centers of 32 countries who participated in this study, 71 centers from 17 countries had at least 1 eligible stroke patient. Of 432 patients included, 323 (74.8%) had acute ischemic stroke, 91 (21.1%) intracranial hemorrhage, and 18 (4.2%) cerebral venous or sinus thrombosis. A total of 183 (42.4%) patients were women, 104 (24.1%) patients were

Published
2021

46. Bottlenecks in the Acute Stroke Care System during the COVID-19 Pandemic in Catalonia

Author

Ramos-Pachón, A, García-Tornel, Á, Millán, M, Ribó, M, Amaro, S, Cardona, P, Martí-Fàbregas, J, Roquer, J, Silva, Y, Ustrell, X, Purroy, F, Gómez-Choco, M, Zaragoza-Brunet, J, Cánovas, D, Krupinski, J, Sala, NM, Palomeras, E, Cocho, D, Redondo, L, Repullo, C, Sanjurjo, E, Carrión, D, López, M, Almendros, MC, Barceló, M, Monedero, J, Catena, E, Rybyeba, M, Diaz, G, Jiménez-Fàbrega, X, Solà, S, Hidalgo, V, Pueyo, MJ, Pérez De La Ossa, N, Urra, X, Ramos-Pachón, A, García-Tornel, Á, Millán, M, Ribó, M, Amaro, S, Cardona, P, Martí-Fàbregas, J, Roquer, J, Silva, Y, Ustrell, X, Purroy, F, Gómez-Choco, M, Zaragoza-Brunet, J, Cánovas, D, Krupinski, J, Sala, NM, Palomeras, E, Cocho, D, Redondo, L, Repullo, C, Sanjurjo, E, Carrión, D, López, M, Almendros, MC, Barceló, M, Monedero, J, Catena, E, Rybyeba, M, Diaz, G, Jiménez-Fàbrega, X, Solà, S, Hidalgo, V, Pueyo, MJ, Pérez De La Ossa, N, and Urra, X

Abstract

Introduction: The COVID-19 pandemic resulted in significant healthcare reorganizations, potentially striking standard medical care. We investigated the impact of the COVID-19 pandemic on acute stroke care quality and clinical outcomes to detect healthcare system's bottlenecks from a territorial point of view. Methods: Crossed-data analysis between a prospective nation-based mandatory registry of acute stroke, Emergency Medical System (EMS) records, and daily incidence of COVID-19 in Catalonia (Spain). We included all stroke code activations during the pandemic (March 15-May 2, 2020) and an immediate prepandemic period (January 26-March 14, 2020). Primary outcomes were stroke code activations and reperfusion therapies in both periods. Secondary outcomes included clinical characteristics, workflow metrics, differences across types of stroke centers, correlation analysis between weekly EMS alerts, COVID-19 cases, and workflow metrics, and impact on mortality and clinical outcome at 90 days. Results: Stroke code activations decreased by 22% and reperfusion therapies dropped by 29% during the pandemic period, with no differences in age, stroke severity, or large vessel occlusion. Calls to EMS were handled 42 min later, and time from onset to hospital arrival increased by 53 min, with significant correlations between weekly COVID-19 cases and more EMS calls (rho = 0.81), less stroke code activations (rho = -0.37), and longer prehospital delays (rho = 0.25). Telestroke centers were afflicted with higher reductions in stroke code activations, reperfusion treatments, referrals to endovascular centers, and increased delays to thrombolytics. The independent odds of death increased (OR 1.6 [1.05-2.4], p 0.03) and good functional outcome decreased (mRS ≤2 at 90 days: OR 0.6 [0.4-0.9], p 0.015) during the pandemic period. Conclusion: During the COVID-19 pandemic, Catalonia's stroke system's weakest points were the delay to EMS alert and a decline of stroke code activations, reper

Published
2021

47. SARS-CoV-2 and Stroke Characteristics A Report From the Multinational COVID-19 Stroke Study Group

Author

Shahjouei, S, Tsivgoulis, G, Farahmand, G, Koza, E, Mowla, A, Sadr, AV, Kia, A, Far, AV, Mondello, S, Cernigliaro, A, Ranta, A, Punter, M, Khodadadi, F, Naderi, S, Sabra, M, Ramezani, M, Harandi, AA, Olulana, O, Chaudhary, D, Lyoubi, A, Campbell, BC, Arenillas, JF, Bock, D, Montaner, J, Neshin, SAS, de Sousa, DA, Tenser, MS, Aires, A, Alfonso, MDL, Alizada, O, Azevedo, E, Goyal, N, Babaeepour, Z, Banihashemi, G, Bonati, LH, Cereda, CW, Chang, JJ, Crnjakovic, M, De Marchis, GM, Del Sette, M, Ebrahimzadeh, SA, Farhoudi, M, Gandoglia, I, Goncalves, B, Griessenauer, CJ, Hanci, MM, Katsanos, AH, Krogias, C, Leker, RR, Lotman, L, Mai, J, Male, S, Malhotra, K, Malojcic, B, Mesquita, T, Ghasemi, AM, Aref, HM, Afshar, ZM, Moon, J, Niemela, M, Jahromi, BR, Nolan, L, Pandhi, A, Park, J-H, Marto, JP, Purroy, F, Ranji-Burachaloo, S, Carreira, NR, Requena, M, Rubiera, M, Sajedi, SA, Sargento-Freitas, J, Sharma, VK, Steiner, T, Tempro, K, Turc, G, Ahmadzadeh, Y, Almasi-Dooghaee, M, Assarzadegan, F, Babazadeh, A, Baharvandat, H, Cardoso, FB, Dev, A, Ghorbani, M, Hamidi, A, Hasheminejad, ZS, Komachali, SH-A, Khorvash, F, Kobeissy, F, Mirkarimi, H, Mohammadi-Vosough, E, Misra, D, Noorian, AR, Nowrouzi-Sohrabi, P, Paybast, S, Poorsaadat, L, Roozbeh, M, Sabayan, B, Salehizadeh, S, Saberi, A, Sepehrnia, M, Vahabizad, F, Yasuda, TA, Ghabaee, M, Rahimian, N, Harirchian, MH, Borhani-Haghighi, A, Azarpazhooh, MR, Arora, R, Ansari, S, Avula, V, Li, J, Abedi, V, Zand, R, Shahjouei, S, Tsivgoulis, G, Farahmand, G, Koza, E, Mowla, A, Sadr, AV, Kia, A, Far, AV, Mondello, S, Cernigliaro, A, Ranta, A, Punter, M, Khodadadi, F, Naderi, S, Sabra, M, Ramezani, M, Harandi, AA, Olulana, O, Chaudhary, D, Lyoubi, A, Campbell, BC, Arenillas, JF, Bock, D, Montaner, J, Neshin, SAS, de Sousa, DA, Tenser, MS, Aires, A, Alfonso, MDL, Alizada, O, Azevedo, E, Goyal, N, Babaeepour, Z, Banihashemi, G, Bonati, LH, Cereda, CW, Chang, JJ, Crnjakovic, M, De Marchis, GM, Del Sette, M, Ebrahimzadeh, SA, Farhoudi, M, Gandoglia, I, Goncalves, B, Griessenauer, CJ, Hanci, MM, Katsanos, AH, Krogias, C, Leker, RR, Lotman, L, Mai, J, Male, S, Malhotra, K, Malojcic, B, Mesquita, T, Ghasemi, AM, Aref, HM, Afshar, ZM, Moon, J, Niemela, M, Jahromi, BR, Nolan, L, Pandhi, A, Park, J-H, Marto, JP, Purroy, F, Ranji-Burachaloo, S, Carreira, NR, Requena, M, Rubiera, M, Sajedi, SA, Sargento-Freitas, J, Sharma, VK, Steiner, T, Tempro, K, Turc, G, Ahmadzadeh, Y, Almasi-Dooghaee, M, Assarzadegan, F, Babazadeh, A, Baharvandat, H, Cardoso, FB, Dev, A, Ghorbani, M, Hamidi, A, Hasheminejad, ZS, Komachali, SH-A, Khorvash, F, Kobeissy, F, Mirkarimi, H, Mohammadi-Vosough, E, Misra, D, Noorian, AR, Nowrouzi-Sohrabi, P, Paybast, S, Poorsaadat, L, Roozbeh, M, Sabayan, B, Salehizadeh, S, Saberi, A, Sepehrnia, M, Vahabizad, F, Yasuda, TA, Ghabaee, M, Rahimian, N, Harirchian, MH, Borhani-Haghighi, A, Azarpazhooh, MR, Arora, R, Ansari, S, Avula, V, Li, J, Abedi, V, and Zand, R

Abstract

[Figure: see text].

Published
2021

48. Impact of COVID-19 infection on the outcome of patients with ischemic stroke

Author

Martí-Fàbregas, J, Guisado-Alonso, D, Delgado-Mederos, R, Martínez-Domeño, A, Prats-Sánchez, L, Guasch-Jiménez, M, Cardona, P, Núñez-Guillén, A, Requena, M, Rubiera, M, Olivé, M, Bustamante, A, Gomis, M, Amaro, S, Llull, L, Ustrell, X, de Oliveira, GC, Seró, L, Gomez-Choco, M, Mena, L, Serena, J, Viturro, SB, Purroy, F, Vicente, M, Rodríguez-Campello, A, Ois, A, Catena, E, Garcia-Carreira, MC, Barrachina, O, Palomeras, E, Krupinski, J, Almeria, M, Zaragoza, J, Esteve, P, Cocho, D, Moreira, A, van Eendenburg, C, Codas, JE, de la Ossa, NP, Salvat, M, Camps-Renom, P, Martí-Fàbregas, J, Guisado-Alonso, D, Delgado-Mederos, R, Martínez-Domeño, A, Prats-Sánchez, L, Guasch-Jiménez, M, Cardona, P, Núñez-Guillén, A, Requena, M, Rubiera, M, Olivé, M, Bustamante, A, Gomis, M, Amaro, S, Llull, L, Ustrell, X, de Oliveira, GC, Seró, L, Gomez-Choco, M, Mena, L, Serena, J, Viturro, SB, Purroy, F, Vicente, M, Rodríguez-Campello, A, Ois, A, Catena, E, Garcia-Carreira, MC, Barrachina, O, Palomeras, E, Krupinski, J, Almeria, M, Zaragoza, J, Esteve, P, Cocho, D, Moreira, A, van Eendenburg, C, Codas, JE, de la Ossa, NP, Salvat, M, and Camps-Renom, P

Abstract

BACKGROUND AND PURPOSE: We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic stroke with or without coronavirus disease 2019 (COVID-19) infection. METHODS: A prospective, observational, multicentre cohort study in Catalonia, Spain. Recruitment was consecutive from mid-March to mid-May 2020. Patients had an acute ischemic stroke within 48 hours and a previous modified Rankin Scale (mRS) score of 0 to 3. We collected demographic data, vascular risk factors, prior mRS score, National Institutes of Health Stroke Scale score, rate of reperfusion therapies, logistics, and metrics. Primary end point was functional outcome at 3 months. Favourable outcome was defined depending on the previous mRS score. Secondary outcome was mortality at 3 months. We performed mRS shift and multivariable analyses. RESULTS: We evaluated 701 patients (mean age 72.3±13.3 years, 60.5% men) and 91 (13%) had COVID-19 infection. Median baseline National Institutes of Health Stroke Scale score was higher in patients with COVID-19 compared with patients without COVID-19 (8 [3–18] versus 6 [2–14], P=0.049). Proportion of patients with a favourable functional outcome was 33.7% in the COVID-19 and 47% in the non-COVID-19 group. However, after a multivariable logistic regression analysis, COVID-19 infection did not increase the probability of unfavourable functional outcome. Mortality rate was 39.3% among patients with COVID-19 and 16.1% in the non-COVID-19 group. In the multivariable logistic regression analysis, COVID-19 infection was a risk factor for mortality (hazard ratio, 3.14 [95% CI, 2.10–4.71]; P<0.001). CONCLUSIONS: Patients with ischemic stroke and COVID-19 infection have more severe strokes and a higher mortality than patients with stroke without COVID-19 infection. However, functional outcome is comparable in both groups.

Published
2021

49. Effectiveness of thrombectomy in stroke according to baseline prognostic factors: inverse probability of treatment weighting analysis of a population-based registry

Author

Rudilosso, S, Ríos, J, Rodríguez, A, Gomis, M, Vera, V, Gómez-Choco, M, Renú, A, Matos, N, Llull, L, Purroy, F, Amaro, S, Terceño, M, Obach, V, Serena, J, Martí-Fàbregas, J, Cardona, P, Molina, C, Rodríguez-Campello, A, Cánovas, D, Krupinski, J, Ustrell, X, Torres, F, Román, LS, Salvat-Plana, M, Jiménez-Fàbrega, FX, Palomeras, E, Catena, E, Colom, C, Cocho, D, Baiges, J, Aragones, JM, Diaz, G, Costa, X, Almendros, MC, Rybyeba, M, Barceló, M, Carrión, D, Lòpez, MN, Sanjurjo, E, de la Ossa, NP, Urra, X, Chamorro, Á, Rudilosso, S, Ríos, J, Rodríguez, A, Gomis, M, Vera, V, Gómez-Choco, M, Renú, A, Matos, N, Llull, L, Purroy, F, Amaro, S, Terceño, M, Obach, V, Serena, J, Martí-Fàbregas, J, Cardona, P, Molina, C, Rodríguez-Campello, A, Cánovas, D, Krupinski, J, Ustrell, X, Torres, F, Román, LS, Salvat-Plana, M, Jiménez-Fàbrega, FX, Palomeras, E, Catena, E, Colom, C, Cocho, D, Baiges, J, Aragones, JM, Diaz, G, Costa, X, Almendros, MC, Rybyeba, M, Barceló, M, Carrión, D, Lòpez, MN, Sanjurjo, E, de la Ossa, NP, Urra, X, and Chamorro, Á

Abstract

Background and Purpose In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Methods Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score <6, proximal vertebrobasilar occlusion, supratherapeutic international normalized ratio >3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups’ criteria). Results Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3). Conclusions Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors.

Published
2021

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