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460 results on '"Puri K"'

1. Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms

Author

Vladan P. Čokić, Olivera Mitrović-Ajtić, Bojana B. Beleslin-Čokić, Dragana Marković, Marijana Buač, Miloš Diklić, Nada Kraguljac-Kurtović, Svetozar Damjanović, Pavle Milenković, Mirjana Gotić, and Puri K. Raj

Subjects
Pathology, RB1-214
Abstract

The recent JAK1/2 inhibitor trial in myeloproliferative neoplasms (MPNs) showed that reducing inflammation can be more beneficial than targeting gene mutants. We evaluated the proinflammatory IL-6 cytokine and JAK-STAT signaling pathway related genes in circulating CD34+ cells of MPNs. Regarding laboratory data, leukocytosis has been observed in polycythemia vera (PV) and JAK2V617F mutation positive versus negative primary myelofibrosis (PMF) patients. Moreover, thrombocytosis was reduced by JAK2V617F allele burden in essential thrombocythemia (ET) and PMF. 261 significantly changed genes have been detected in PV, 82 in ET, and 94 genes in PMF. The following JAK-STAT signaling pathway related genes had augmented expression in CD34+ cells of MPNs: CCND3 and IL23A regardless of JAK2V617F allele burden; CSF3R, IL6ST, and STAT1/2 in ET and PV with JAK2V617F mutation; and AKT2, IFNGR2, PIM1, PTPN11, and STAT3 only in PV. STAT5A gene expression was generally reduced in MPNs. IL-6 cytokine levels were increased in plasma, as well as IL-6 protein levels in bone marrow stroma of MPNs, dependent on JAK2V617F mutation presence in ET and PMF patients. Therefore, the JAK2V617F mutant allele burden participated in inflammation biomarkers induction and related signaling pathways activation in MPNs.

Published
2015
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2. Study Of Knowledge, Attitude And Behaviour Pattern On HIV/AIDS Among Medical Students

Author

Puri K J P S, Gulati Bobby, Pall Anuj, and Madan Anita

Subjects
Dermatology, RL1-803
Abstract

A survey of 200 students aged 18 to 23 years attending GGS Medical College and Hospital, Faridkot, assessed their sexual risk practices, AIDS- specific attitudes and beliefs, sexual relationship pattern and preferences and social characteristics. Overall, 39% of students were sexually experienced and these young people had on average, one sexual partner. Only 10% of sexually experienced students said they consistently used condom and 29% said they never did. Unprotected vaginal intercourse was the predominant and preferred sexual practice; it was also the practice that most often occurred with their last sexual partner. In all, 28% of students defined â€safer sex†as condom use. Many young people believe that AIDS is a threat only to members of particular â€risk groupsâ€; relatively few believed that they could get AIDS (17%) or said that AIDS information had influenced their sexual behaviour (29% of those who were sexually experienced). Females were more likely than males to prefer having an exclusive partner and males were more likely to prefer having casual partners.

Published
2003

3. Computational Campaign on the MTU T161 Cascade

Author

Rasquin, M., Hillewaert, K., Colombo, A., Bassi, F., Massa, F., Puri, K., Iyer, A. S., Abe, Y., Witherden, F. D., Vermeire, B. C., Vincent, P. E., Hirschel, Ernst Heinrich, Founding Editor, Schröder, Wolfgang, Series Editor, Boersma, Bendiks Jan, Editorial Board Member, Fujii, Kozo, Editorial Board Member, Haase, Werner, Editorial Board Member, Leschziner, Michael A., Editorial Board Member, Periaux, Jacques, Editorial Board Member, Pirozzoli, Sergio, Editorial Board Member, Rizzi, Arthur, Editorial Board Member, Roux, Bernard, Editorial Board Member, Shokin, Yurii I., Editorial Board Member, Mäteling, Esther, Managing Editor, Hirsch, Charles, editor, Hillewaert, Koen, editor, Hartmann, Ralf, editor, Couaillier, Vincent, editor, Boussuge, Jean-Francois, editor, Chalot, Frederic, editor, and Bosniakov, Sergey, editor

Published
2021
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4. High-Lift Low Pressure Turbines T106-A and T106-C

Author

Mouriaux, S., Puri, K., Hirschel, Ernst Heinrich, Founding Editor, Schröder, Wolfgang, Series Editor, Boersma, Bendiks Jan, Editorial Board Member, Fujii, Kozo, Editorial Board Member, Haase, Werner, Editorial Board Member, Leschziner, Michael A., Editorial Board Member, Periaux, Jacques, Editorial Board Member, Pirozzoli, Sergio, Editorial Board Member, Rizzi, Arthur, Editorial Board Member, Roux, Bernard, Editorial Board Member, Shokin, Yurii I., Editorial Board Member, Mäteling, Esther, Managing Editor, Hirsch, Charles, editor, Hillewaert, Koen, editor, Hartmann, Ralf, editor, Couaillier, Vincent, editor, Boussuge, Jean-Francois, editor, Chalot, Frederic, editor, and Bosniakov, Sergey, editor

Published
2021
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5. Parallelisation to Several Tens-of-Thousands of Cores

Author

Bassi, F., Botti, L., Verzeroli, L., Hartmann, R., Jägersküpper, J., Martin, E., Lorteau, M., Vincent, P. E., Witherden, F. D., Vermeire, B. C., Park, J. S., Iyer, A., Puri, K., Gutzwiller, D., Hirsch, C., Chalot, F., Hirschel, Ernst Heinrich, Founding Editor, Schröder, Wolfgang, Series Editor, Boersma, Bendiks Jan, Editorial Board Member, Fujii, Kozo, Editorial Board Member, Haase, Werner, Editorial Board Member, Leschziner, Michael A., Editorial Board Member, Periaux, Jacques, Editorial Board Member, Pirozzoli, Sergio, Editorial Board Member, Rizzi, Arthur, Editorial Board Member, Roux, Bernard, Editorial Board Member, Shokin, Yurii I., Editorial Board Member, Mäteling, Esther, Managing Editor, Hirsch, Charles, editor, Hillewaert, Koen, editor, Hartmann, Ralf, editor, Couaillier, Vincent, editor, Boussuge, Jean-Francois, editor, Chalot, Frederic, editor, and Bosniakov, Sergey, editor

Published
2021
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11. (1137) HLA Diversity Transcends Donor-Recipient Race Matching

Author

Spinner, J., primary, Fuentes-Baldemar, A., additional, Tu, T., additional, Robinsin, P., additional, Nicholas, S., additional, Hope, K., additional, Puri, K., additional, Denfield, S., additional, Tunuguntla, H., additional, Price, J., additional, Choudhry, S., additional, Dreyer, W., additional, and Jindra, P., additional

Published
2023
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40. Hospital outcomes for pediatric heart transplant recipients undergoing tracheostomy: A multi-institutional analysis.

Author

Spinner, JA, Denfield, SW, Puri, K, Morris, SA, Costello, JM, Moffett, BS, Wang, Y, Shekerdemian, LS, Tunuguntla, HP, Price, JF, Heinle, JS, Adachi, I, Dreyer, WJ, Cabrera, AG, Spinner, JA, Denfield, SW, Puri, K, Morris, SA, Costello, JM, Moffett, BS, Wang, Y, Shekerdemian, LS, Tunuguntla, HP, Price, JF, Heinle, JS, Adachi, I, Dreyer, WJ, and Cabrera, AG

Abstract

Tracheostomy is associated with increased mortality and resource utilization in children with CHD. However, the prevalence and hospital outcomes of tracheostomy in children with HTx are not known. We describe the prevalence and compare the post-HTx hospital outcomes of pediatric patients with Pre-TT and Post-TT to those without tracheostomy. A multi-institutional retrospective cohort study was performed using the Pediatric Health Information System database. Hospital mortality, mediastinitis, LOS, and costs were compared among patients with Pre-TT, Post-TT, and no tracheostomy. Pre-TT was identified in 29 (1.1%) and Post-TT was identified in 41 (1.6%) of 2603 index HTx hospitalizations. Patients with Pre-TT were younger and more likely to have CHD, a non-cardiac birth defect, or an airway anomaly compared to those without Pre-TT. Pre-TT was not independently associated with increased post-HTx in-hospital mortality. Age at HTx < 1 year, CHD, and Post-TT were associated with increased in-hospital mortality. Pre-TT that occurred during the HTx hospitalization and Post-TT were associated with increased resource utilization. Tracheostomy was not associated with mediastinitis.

Published
2021

47. AT1R-Ab: A New Player in Pediatric Heart Transplant AMR?

Author

Spinner, J.A., primary, Philogene, M., additional, Nicholas, S., additional, Jindra, P., additional, Choudhry, S., additional, Hope, K.D., additional, Puri, K., additional, Tunuguntla, H.P., additional, Price, J., additional, Denfield, S.W., additional, and Dreyer, W.J., additional

Published
2021
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