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14 results on '"Purcell, Madeleine"'

1. Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies

Author

Stein, Sydney R., Ramelli, Sabrina C., Ramos-Benitez, Marcos J., Platt, Andrew P., Dickey, James M., Curran, Shelly J., Babyak, Ashley L., Valencia, Luis Perez, Richert, Mary E., Vannella, Kevin M., Chertow, Daniel S., Kleiner, David E., Hewitt, Stephen M., Young, Willie J., Young, Sarah P., Gasmi, Billel, De Melo, Michelly Sampaio, Desar, Sabina, Tadros, Saber, Nasir, Nadia, Jin, Xueting, Rajan, Sharika, Dikoglu, Esra, Ozkaya, Neval, Ylaya, Kris, Chung, Joon-Yong, Pittaluga, Stefania, Smith, Grace, Emanuel, Elizabeth R., Kelsall, Brian, Olivera, Justin A., Blawas, Megan, Grazioli, Alison, Hays, Nicole, Purcell, Madeleine, Singireddy, Shreya, Wu, Jocelyn, Raja, Katherine, Curto, Ryan, Chung, Jean, Borth, Amy, Bowers, Kimberly, Weichold, Anne, Minor, Paula, Moshref, Mirahmad, Kelly, Emily, Sajadi, Mohammad M., Scalea, Thomas M., Tran, Douglas, Madathil, Ronson J., Dahi, Siamak, Deatrick, Kristopher B., Krause, Eric M., Rabin, Joseph, Herrold, Joseph A., Tabatabai, Ali, Hochberg, Eric, Cornachione, Christopher, Levine, Andrea R., Saharia, Kapil K., Richards, Justin E., Elder, John, Burke, Allen, Mazzeffi, Michael A., Christenson, Robert, Chancer, Zackary, Abdulmahdi, Mustafa, Sopha, Sabrina, Goldberg, Tyler, Soherwardi, Shahabuddin, Sangwan, Yashvir, McCurdy, Michael T., Sudano, Kristen, Blume, Diane, Radin, Bethany, Arnouk, Madhat, Eagan, James W., Jr., Herr, Daniel L., Zerbe, Christa, Sen, H. Nida, Wang, Yujuan, Kodati, Shilpa, Lee, Jung Wha, Perez, Paola, Singh, Manmeet, Yinda, Kwe Claude, Platt, Andrew, Munster, Vincent J., de Wit, Emmie, Warner, Blake M., and Chan, Chi-Chao

Published
2023
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2. SARS-CoV-2 infection and persistence in the human body and brain at autopsy

Author

Stein, Sydney R., Ramelli, Sabrina C., Grazioli, Alison, Chung, Joon-Yong, Singh, Manmeet, Yinda, Claude Kwe, Winkler, Clayton W., Sun, Junfeng, Dickey, James M., Ylaya, Kris, Ko, Sung Hee, Platt, Andrew P., Burbelo, Peter D., Quezado, Martha, Pittaluga, Stefania, Purcell, Madeleine, Munster, Vincent J., Belinky, Frida, Ramos-Benitez, Marcos J., Boritz, Eli A., Lach, Izabella A., Herr, Daniel L., Rabin, Joseph, Saharia, Kapil K., Madathil, Ronson J., Tabatabai, Ali, Soherwardi, Shahabuddin, McCurdy, Michael T., Peterson, Karin E., Cohen, Jeffrey I., de Wit, Emmie, Vannella, Kevin M., Hewitt, Stephen M., Kleiner, David E., and Chertow, Daniel S.

Published
2022
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3. SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women

Author

Lee, Youri, Grubbs, Gabrielle, Ramelli, Sabrina C., Levine, Andrea R., Bathula, Allison, Saharia, Kapil, Purcell, Madeleine, Singireddy, Shreya, Dugan, Colleen L., Kirchoff, Lindsey, Lankford, Allison, Cipriano, Sarah, Curto, Ryan A., Wu, Jocelyn, Raja, Katherine, Kelley, Emily, Herr, Daniel, Vannella, Kevin M., Ravichandran, Supriya, Tang, Juanjie, Harris, Anthony, Sajadi, Mohammad, Chertow, Daniel S., Grazioli, Alison, and Khurana, Surender

Published
2022
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5. 433. Thromboinflammation in COVID-19 and association with death in patients on ECMO

Author

Platt, Andrew, primary, Callier, Viviane, additional, Hu, Zonghui, additional, Warner, Seth, additional, Stein, Syndey R, additional, Anders, Megan, additional, Ricotta, Emily, additional, Stantliff, Trevor M, additional, Wu, Jocelyn, additional, Hays, Nicole, additional, Raja, Katherine, additional, Curto, Ryan, additional, Purcell, Madeleine, additional, Ramelli, Sabrina, additional, Ramos-Benitez, Marcos J, additional, Lach, Izabella, additional, Dickey, James, additional, Strich, Jeffrey R, additional, Vannella, Kevin M, additional, Gibbons, Miranda, additional, Tabatabai, Ali, additional, Saharia, Kapil K, additional, Madathil, Ronson, additional, Rabin, Joseph, additional, Grazioli, Alison, additional, Follmann, Dean, additional, and Chertow, Daniel S, additional

Published
2023
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6. Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breast milk feeding

Author

Sajadi, Mohammad M., primary, Shokatpour, Narjes, additional, Purcell, Madeleine, additional, Tehrani, Zahra Rikhtegaran, additional, Lankford, Allison, additional, Bathula, Allison, additional, Campbell, James D., additional, Hammershaimb, Elizabeth Adrianne, additional, Deatrick, Kristopher B., additional, Bor, Casey, additional, Parsell, Dawn M., additional, Dugan, Colleen, additional, Levine, Andrea R., additional, Ramelli, Sabrina C., additional, Chertow, Daniel S., additional, Herr, Daniel L., additional, Saharia, Kapil K., additional, Lewis, George K., additional, and Grazioli, Alison, additional

Published
2023
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7. Histopathology and SARS-CoV-2 cellular localization in eye tissues of COVID-19 autopsies

Author

Sen, H. Nida, primary, Vannella, Kevin M., additional, Wang, Yujuan, additional, Chung, Joon-Yong, additional, Kodati, Shilpa, additional, Ramelli, Sabrina C., additional, Lee, Jung Wha, additional, Perez, Paola, additional, Stein, Sydney R., additional, Grazioli, Alison, additional, Dickey, James M., additional, Ylaya, Kris, additional, Singh, Manmeet, additional, Yinda, Kwe Claude, additional, Platt, Andrew, additional, Ramos-Benitez, Marcos J., additional, Zerbe, Christa, additional, Munster, Vincent J., additional, de Wit, Emmie, additional, Warner, Blake M, additional, Herr, Daniel L., additional, Rabin, Joseph, additional, Saharia, Kapil K, additional, Kleiner, David E., additional, Hewitt, Stephen M., additional, Chan, Chi-Chao, additional, Chertow, Daniel S., additional, Platt, Andrew P., additional, Curran, Shelly J., additional, Babyak, Ashley L., additional, Valencia, Luis Perez, additional, Richert, Mary E., additional, Young, Willie J., additional, Young, Sarah P., additional, Gasmi, Billel, additional, De Melo, Michelly Sampaio, additional, Desar, Sabina, additional, Tadros, Saber, additional, Nasir, Nadia, additional, Jin, Xueting, additional, Rajan, Sharika, additional, Dikoglu, Esra, additional, Ozkaya, Neval, additional, Pittaluga, Stefania, additional, Smith, Grace, additional, Emanuel, Elizabeth R., additional, Kelsall, Brian, additional, Olivera, Justin A., additional, Blawas, Megan, additional, Hays, Nicole, additional, Purcell, Madeleine, additional, Singireddy, Shreya, additional, Wu, Jocelyn, additional, Raja, Katherine, additional, Curto, Ryan, additional, Chung, Jean, additional, Borth, Amy, additional, Bowers, Kimberly, additional, Weichold, Anne, additional, Minor, Paula, additional, Moshref, Mirahmad, additional, Kelly, Emily, additional, Sajadi, Mohammad M., additional, Scalea, Thomas M., additional, Tran, Douglas, additional, Madathil, Ronson J., additional, Dahi, Siamak, additional, Deatrick, Kristopher B., additional, Krause, Eric M., additional, Herrold, Joseph A., additional, Tabatabai, Ali, additional, Hochberg, Eric, additional, Cornachione, Christopher, additional, Levine, Andrea R., additional, Saharia, Kapil K., additional, Richards, Justin E., additional, Elder, John, additional, Burke, Allen, additional, Mazzeffi, Michael A., additional, Christenson, Robert, additional, Chancer, Zackary, additional, Abdulmahdi, Mustafa, additional, Sopha, Sabrina, additional, Goldberg, Tyler, additional, Soherwardi, Shahabuddin, additional, Sangwan, Yashvir, additional, McCurdy, Michael T., additional, Sudano, Kristen, additional, Blume, Diane, additional, Radin, Bethany, additional, Arnouk, Madhat, additional, and Eagan, James W., additional

Published
2023
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9. Pulmonary Co-Infections Detected Premortem Underestimate Postmortem Findings in a COVID-19 Autopsy Case Series.

Author

Platt, Andrew P., Bradley, Benjamin T., Nasir, Nadia, Stein, Sydney R., Ramelli, Sabrina C., Ramos-Benitez, Marcos J., Dickey, James M., Purcell, Madeleine, Singireddy, Shreya, Hays, Nicole, Wu, Jocelyn, Raja, Katherine, Curto, Ryan, Salipante, Stephen J., Chisholm, Claire, Carnes, Stephanie, Marshall, Desiree A., Cookson, Brad T., Vannella, Kevin M., and Madathil, Ronson J.

Subjects
COVID-19 pandemic, AUTOPSY, COVID-19, MYCOSES, INTENSIVE care units, POLYMERASE chain reaction
Abstract

Bacterial and fungal co-infections are reported complications of coronavirus disease 2019 (COVID-19) in critically ill patients but may go unrecognized premortem due to diagnostic limitations. We compared the premortem with the postmortem detection of pulmonary co-infections in 55 fatal COVID-19 cases from March 2020 to March 2021. The concordance in the premortem versus the postmortem diagnoses and the pathogen identification were evaluated. Premortem pulmonary co-infections were extracted from medical charts while applying standard diagnostic definitions. Postmortem co-infection was defined by compatible lung histopathology with or without the detection of an organism in tissue by bacterial or fungal staining, or polymerase chain reaction (PCR) with broad-range bacterial and fungal primers. Pulmonary co-infection was detected premortem in significantly fewer cases (15/55, 27%) than were detected postmortem (36/55, 65%; p < 0.0001). Among cases in which co-infection was detected postmortem by histopathology, an organism was identified in 27/36 (75%) of cases. Pseudomonas, Enterobacterales, and Staphylococcus aureus were the most frequently identified bacteria both premortem and postmortem. Invasive pulmonary fungal infection was detected in five cases postmortem, but in no cases premortem. According to the univariate analyses, the patients with undiagnosed pulmonary co-infection had significantly shorter hospital (p = 0.0012) and intensive care unit (p = 0.0006) stays and significantly fewer extra-pulmonary infections (p = 0.0021). Bacterial and fungal pulmonary co-infection are under-recognized complications in critically ill patients with COVID-19. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breastfeeding

Author

Sajadi, Mohammad M., primary, Shokatpour, Narjes, additional, Bathula, Allison, additional, Tehrani, Zahra, additional, Lankford, Allison, additional, Purcell, Madeleine, additional, Campbell, James D., additional, Hammershaimb, Elizabeth Adrianne Duque, additional, Deatrick, Kristopher B., additional, Bor, Casey, additional, Parsell, Dawn M., additional, Dugan, Colleen, additional, Levine, Andrea, additional, Ramelli, Sabrina C., additional, Chertow, Daniel, additional, Herr, Daniel L., additional, Lewis, George K., additional, and Grazioli, Alison, additional

Published
2021
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11. SARS-CoV-2 infection and persistence throughout the human body and brain

Author

Chertow, Daniel, primary, Stein, Sydney, additional, Ramelli, Sabrina, additional, Grazioli, Alison, additional, Chung, Joon-Yong, additional, Singh, Manmeet, additional, Yinda, Claude Kwe, additional, Winkler, Clayton, additional, Dickey, James, additional, Ylaya, Kris, additional, Ko, Sung Hee, additional, Platt, Andrew, additional, Burbelo, Peter, additional, Quezado, Martha, additional, Pittaluga, Stefania, additional, Purcell, Madeleine, additional, Munster, Vincent, additional, Belinky, Frida, additional, Ramos-Benitez, Marcos, additional, Boritz, Eli, additional, Herr, Daniel, additional, Rabin, Joseph, additional, Saharia, Kapil, additional, Madathil, Ronson, additional, Tabatabai, Ali, additional, Soherwardi, Shahabuddin, additional, McCurdy, Michael, additional, Peterson, Karin, additional, Cohen, Jeffrey, additional, de Wit, Emmie, additional, Vannella, Kevin, additional, Hewitt, Stephen, additional, and Kleiner, David, additional

Published
2021
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12. 185: PREVALENCE OF BACTERIAL AND FUNGAL COINFECTIONS IN A COVID-19 AUTOPSY CASE SERIES

Author

Platt, Andrew, primary, Nasir, Nadia, additional, Ben, Bradley, additional, Stein, Sydney, additional, Ramelli, Sabrina, additional, Ramos-Benitez, Marcos, additional, Dickey, James, additional, Purcell, Madeleine, additional, Wu, Jocelyn, additional, Singireddy, Shreya, additional, Salipante, Stephen, additional, Chisholm, Claire, additional, Grazioli, Alison, additional, Madathil, Ronson, additional, Rabin, Joseph, additional, Saharia, Kapil, additional, Kleiner, David, additional, Hewitt, Stephen, additional, Leiberman, Joshua, additional, and Chertow, Daniel, additional

Published
2021
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13. Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice

Author

Moye, Abigail R., primary, Bedoni, Nicola, additional, Cunningham, Jessica G., additional, Sanzhaeva, Urikhan, additional, Tucker, Eric S., additional, Mathers, Peter, additional, Peter, Virginie G., additional, Quinodoz, Mathieu, additional, Paris, Liliana P., additional, Coutinho-Santos, Luísa, additional, Camacho, Pedro, additional, Purcell, Madeleine G., additional, Winkelmann, Abbie C., additional, Foster, James A., additional, Pugacheva, Elena N., additional, Rivolta, Carlo, additional, and Ramamurthy, Visvanathan, additional

Published
2019
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14. SARS-CoV-2 infection perturbs the gastrointestinal tract and induces modest microbial translocation across the intestinal barrier.

Author

Brooks, Kelsie, Nelson, Christine E., Aguilar, Cynthia, Hoang, Timothy N., Ortiz, Alexandra M., Langner, Charlotte A., Yee, Debra S., Flynn, Jacob K., Vrba, Sophia, Laidlaw, Elizabeth, Vannella, Kevin M., Grazioli, Alison, Saharia, Kapil K., Purcell, Madeleine, Singireddy, Shreya, Wu, Jocelyn, Stankiewicz, Jason, Chertow, Daniel S., Sereti, Irini, and Paiardini, Mirko

Subjects
*BACTERIAL antigens, *RHESUS monkeys, *INFLAMMATION, *B cells, *CELL populations
Abstract

SARS-CoV-2 infects via the respiratory tract, but COVID-19 includes an array of non-respiratory symptoms, among them gastrointestinal (GI) manifestations such as vomiting and diarrhea. Here we investigated the GI pathology of SARS-CoV-2 infections in rhesus macaques and humans. Macaques experienced mild infection with USA-WA1/2020 and shed viral RNA in the respiratory tract and stool, including subgenomic RNA indicative of replication in the GI tract. Intestinal immune cell populations were disturbed, with significantly fewer proliferating (Ki67+) jejunal B cells in SARSCoV-2-infected macaques than uninfected ones. Modest translocation of bacteria/bacterial antigen was observed across the colonic epithelium, with a corresponding significant increase in plasma soluble CD14 (sCD14) that may be induced by LPS. Human plasma demonstrated significant decreases in interleukin (IL)-6 and sCD14 upon recovery from COVID-19, suggesting resolution of inflammation and response to translocated bacteria. sCD14 significantly positively correlated with zonulin, an indicator of gut barrier integrity, and IL-6. These results demonstrate that GI perturbations such as microbial translocation can occur in even mild SARS-CoV-2 infections and may contribute to the COVID-19 inflammatory state. [ABSTRACT FROM AUTHOR]

Published
2024
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