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486 results on '"Puranik R"'

1. Dentigerous cyst associated with permanent central incisor: A rare entity

Author

Desai R, Vanaki S, Puranik R, and Tegginamani A

Subjects
Central incisor, Dentigerous cyst, Unerupted, Dentistry, RK1-715
Abstract

Dentigerous cyst is one of the most prevalent types of odontogenic cyst and is associated with crown of an unerupted or developing tooth. Dentigerous cyst is more commonly seen with mandibular third molar and maxillary canine and rarely other teeth are involved. Here we report a case of dentigerous cyst involving permanent maxillary central incisor.

Published
2005

2. Cardiac magnetic resonance imaging in systemic sclerosis: Heart involvement in high-resolution.

Author

Fairley, JL, O'Rourke, R, Puranik, R, Nikpour, M, Fairley, JL, O'Rourke, R, Puranik, R, and Nikpour, M

Abstract

Cardiac magnetic resonance imaging (CMR) is the gold-standard non-invasive method of assessing cardiac structure and function, including tissue characterisation. In systemic sclerosis (SSc), heart involvement (SHI) is a leading cause of mortality yet remains poorly understood. SHI is underestimated by conventional echocardiography, and CMR provides an important opportunity to better identify and quantify subtle myocardial changes including oedema and fibrosis. This review summarises current CMR techniques, the role of CMR in SSc and SHI, and the opportunities to further our understanding of its pathogenesis and management.

Published
2024

5. Comprehensive Multidisciplinary Assessment Leads to Excellent Outcomes in Septal Reduction Therapies for Hypertrophic Cardiomyopathy

Author

Geraghty, L., primary, Moonen, A., additional, Burns, C., additional, Medi, C., additional, Puranik, R., additional, Adams, M., additional, Hunyor, I., additional, Simmons, L., additional, Hellyer, R., additional, Yeates, L., additional, Richmond, D., additional, Bannon, P., additional, Semsarian, C., additional, and Gray, B., additional

Published
2023
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21. Exercise Intolerance, Benefits, and Prescription for People Living With a Fontan Circulation: The Fontan Fitness Intervention Trial (F-FIT)-Rationale and Design

Author

Tran, DL, Gibson, H, Maiorana, AJ, Verrall, CE, Baker, DW, Clode, M, Lubans, DR, Zannino, D, Bullock, A, Ferrie, S, Briody, J, Simm, P, Wijesekera, V, D'Almeida, M, Gosbell, SE, Davis, GM, Weintraub, R, Keech, AC, Puranik, R, Ugander, M, Justo, R, Zentner, D, Majumdar, A, Grigg, L, Coombes, JS, d'Udekem, Y, Morris, NR, Ayer, J, Celermajer, DS, Cordina, R, Tran, DL, Gibson, H, Maiorana, AJ, Verrall, CE, Baker, DW, Clode, M, Lubans, DR, Zannino, D, Bullock, A, Ferrie, S, Briody, J, Simm, P, Wijesekera, V, D'Almeida, M, Gosbell, SE, Davis, GM, Weintraub, R, Keech, AC, Puranik, R, Ugander, M, Justo, R, Zentner, D, Majumdar, A, Grigg, L, Coombes, JS, d'Udekem, Y, Morris, NR, Ayer, J, Celermajer, DS, and Cordina, R

Abstract

Background: Despite developments in surgical techniques and medical care, people with a Fontan circulation still experience long-term complications; non-invasive therapies to optimize the circulation have not been established. Exercise intolerance affects the majority of the population and is associated with worse prognosis. Historically, people living with a Fontan circulation were advised to avoid physical activity, but a small number of heterogenous, predominantly uncontrolled studies have shown that exercise training is safe-and for unique reasons, may even be of heightened importance in the setting of Fontan physiology. The mechanisms underlying improvements in aerobic exercise capacity and the effects of exercise training on circulatory and end-organ function remain incompletely understood. Furthermore, the optimal methods of exercise prescription are poorly characterized. This highlights the need for large, well-designed, multi-center, randomized, controlled trials. Aims and Methods: The Fontan Fitness Intervention Trial (F-FIT)-a phase III clinical trial-aims to optimize exercise prescription and delivery in people with a Fontan circulation. In this multi-center, randomized, controlled study, eligible Fontan participants will be randomized to either a 4-month supervised aerobic and resistance exercise training program of moderate-to-vigorous intensity followed by an 8-month maintenance phase; or usual care (control group). Adolescent and adult (≥16 years) Fontan participants will be randomized to either traditional face-to-face exercise training, telehealth exercise training, or usual care in a three-arm trial with an allocation of 2:2:1 (traditional:telehealth:control). Children (<16 years) will be randomized to either a physical activity and exercise program of moderate-to-vigorous intensity or usual care in a two-arm trial with a 1:1 allocation. The primary outcome is a change in aerobic exercise capacity (peak oxygen uptake) at 4-months. Secondary outcom

Published
2022

24. NSW HEARTS: The NSW Inherited Cardiomyopathy Cohort Study protocol

Author

Butters, A., primary, Do, J., additional, Stafford, F., additional, Krishnan, N., additional, Brown, J., additional, Hespe, S., additional, Richardson, E., additional, Bagnall, R., additional, Bhaskaran, A., additional, Burns, C., additional, Driscoll, T., additional, Fatkin, D., additional, Gray, B., additional, Iglesias, C., additional, Isbister, J., additional, Jabbour, A., additional, Johnson, R., additional, Kumar, S., additional, Leslie, F., additional, MacArthur, D., additional, Nowak, N., additional, Pouliopoulos, J., additional, Puranik, R., additional, Semsarian, C., additional, Sweeting, J., additional, Sy, R., additional, Ugander, M., additional, Yeates, L., additional, and Ingles, J., additional

Published
2022
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30. Challenges in Diagnosis of Mesenchymal Chondrosarcoma “The Importance of Histopathologic Analysis”.

Author

Goudar, Archana, Puranik, R. S., Puranik, S. R., Ramesh, Saahil, and Yog Naag Amaran, E. G.

Subjects
SURGICAL margin, LITERATURE reviews, ALVEOLAR process, BENIGN tumors, ORAL radiography
Abstract

This article discusses the challenges in diagnosing mesenchymal chondrosarcoma, a rare and aggressive tumor that can mimic benign oral growths. The case report presented in the article describes a 34-year-old male patient with a mass in the mandibular anterior region. The tumor was initially thought to be benign due to its clinical appearance, but histopathologic analysis confirmed it to be mesenchymal chondrosarcoma. The article emphasizes the importance of thorough evaluation and surgical excision with negative margins for successful treatment. [Extracted from the article]

Published
2024

35. Germline BRCA-Associated Endometrial Carcinoma Is a Distinct Clinicopathologic Entity

Author

Jonge, M.M. de, Ritterhouse, L.L., Kroon, C.D. de, Vreeswijk, M.P.G., Segal, J.P., Puranik, R., Rookus, M.A., Hogervorst, F.B.L., Leeuwen, F.E. van, Adank, M.A., Schmidt, M.K., Jenner, D.J., Collee, J.M., Ouweland, A.M.W. van den, Hooning, M.J., Boere, I.A., Asperen, C.J. van, Devilee, P., Luijt, R.B. van der, Cronenburg, T.C.T.E.F. van, Wevers, M.R., Mensenkamp, A.R., Ausems, M.G.E.M., Koudijs, M.J., Meijers-Heijboer, H.E.J., Os, T.A.M. van, Engelen, K. van, Gille, J.J.P., Gomez-Garcia, E.B., Blok, M.J., Boer, M. de, Oosterwijk, J.C., Hout, A.H. van der, Mourits, M.J., Bock, G.H. de, Siesling, S., Verloop, J., Broek, E.C. van den, Hollema, H., Smit, V.T.H.B.M., Howitt, B.E., Bosse, T., HEBON Grp, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Life Course Epidemiology (LCE), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Klinische Genetica, MUMC+: DA KG Polikliniek (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Lab Centraal Lab (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Promovendi ODB, Clinical Genetics, and Medical Oncology

Subjects
0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, MAINTENANCE THERAPY, TAMOXIFEN TREATMENT, PROGNOSIS, Germline, Loss of heterozygosity, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, All institutes and research themes of the Radboud University Medical Center, Internal medicine, medicine, Carcinoma, BREAST-CANCER, RISK, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], business.industry, MUTATIONS, Endometrial cancer, WOMEN, Histology, medicine.disease, OVARIAN, UTERINE SEROUS CARCINOMA, 030104 developmental biology, 030220 oncology & carcinogenesis, CLEAR-CELL, Ovarian cancer, business, Cohort study, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Purpose: Whether endometrial carcinoma (EC) should be considered part of the gBRCA1/2-associated hereditary breast and ovarian cancer (HBOC) syndrome is topic of debate. We sought to assess whether ECs occurring in gBRCA carriers are enriched for clinicopathologic and molecular characteristics, thereby supporting a causal relationship. Experimental Design: Thirty-eight gBRCA carriers that developed EC were selected from the nationwide cohort study on hereditary breast and ovarian cancer in the Netherlands (HEBON), and these were supplemented with four institutional cases. Tumor tissue was retrieved via PALGA (Dutch Pathology Registry). Nineteen morphologic features were scored and histotype was determined by three expert gynecologic pathologists, blinded for molecular analyses (UCM-OncoPlus Assay including 1213 genes). ECs with LOH of the gBRCA-wild-type allele (gBRCA/LOHpos) were defined “gBRCA-associated,” those without LOH (gBRCA/LOHneg) were defined “sporadic.” Results: LOH could be assessed for 40 ECs (30 gBRCA1, 10 gBRCA2), of which 60% were gBRCA/LOHpos. gBRCA/LOHpos ECs were more frequently of nonendometrioid (58%, P = 0.001) and grade 3 histology (79%, P < 0.001). All but two were in the TP53-mutated TCGA-subgroup (91.7%, P < 0.001). In contrast, gBRCA/LOHneg ECs were mainly grade 1 endometrioid EC (94%) and showed a more heterogeneous distribution of TCGA-molecular subgroups: POLE-mutated (6.3%), MSI-high (25%), NSMP (62.5%), and TP53-mutated (6.3%). Conclusions: We provide novel evidence in favor of EC being part of the gBRCA-associated HBOC-syndrome. gBRCA-associated ECs are enriched for EC subtypes associated with unfavorable clinical outcome. These findings have profound therapeutic consequences as these patients may benefit from treatment strategies such as PARP inhibitors. In addition, it should influence counseling and surveillance of gBRCA carriers.

Published
2019

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