1. HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia.
- Author
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Gashnikova NM, Astakhova EM, Gashnikova MP, Bocharov EF, Petrova SV, Pun'ko OA, Popkov AV, and Totmenin AV
- Subjects
- Adult, Drug Resistance, Viral drug effects, Female, Humans, Male, Middle Aged, Siberia epidemiology, Anti-Retroviral Agents administration & dosage, Drug Resistance, Viral genetics, HIV Infections drug therapy, HIV Infections epidemiology, HIV Infections genetics, HIV-1 genetics, Mutation, Phylogeny
- Abstract
Introduction . Specific molecular epidemic features of HIV infection in Tyumen Oblast (TO), Russia, were studied. Methods . The genome sequences encoding HIV-1 protease-reverse transcriptase, integrase, and major envelope protein were examined for 72 HIV-1 specimens isolated from the TO resident infected in 2000-2015. Results . The recorded prevalence of HIV-1 subtype A (A1) is 93.1%; HIV-1 subtype B continues to circulate in MSM risk group (1.4%). Solitary instances of HIV-1 recombinant forms, CRF63_02A1 (1.4%) and CRF03_AB (1.4%), were detected as well as two cases of HIV-1 URF63_A1 (2.8%). Phylogenetic analysis showed no HIV-1 clustering according to the duration of infection and risk groups but revealed different epidemic networks confirming that HIV infection spread within local epidemic foci. A high incidence of CXCR4-tropic HIV-1 variants and a higher rate of secondary mutations influencing the virus fitness (K20R, L10V, and I) are observed among the virus specimens isolated from newly infected individuals. Conclusions . The current HIV-1 epidemic in TO develops within the local epidemic networks. Similar to the previous period, HIV-1 subtype A is predominant in TO with sporadic cases of importation of HIV-1 recombinant forms circulating in adjacent areas., Competing Interests: The authors declare that there is no conflict of interests regarding the publication of this paper.
- Published
- 2016
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