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1. The interaction of patients’ physical status and time to endoscopy on mortality risk in patients with upper gastrointestinal bleeding: A national prospective cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Balzano, A, Bazzoli, F, Bennato, R, Bianco, M A, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De Fanis, C, De Filippo, FR, de Franchis, R, Dell‘Era, A, De Nigris, F, De Matthaeis, M, Di Giorgio, P, Di Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana’, B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R, Metrangolo, S, Montalbano, L M, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Bucci, Cristina, Marmo, Clelia, Soncini, Marco, Riccioni, Maria Elena, Laursen, Stig B., Gralnek, Ian M., and Marmo, Riccardo

Published
2024
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3. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Bazzoli, F, Bennato, R, Bianco, MA, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De-Fanis, C, De-Filippo, FR, de-Franchis, R, Dell‘Era, A, De Nigris, F, De-Matthaeis, M, Di-Giorgio, P, Di-Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana', B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R., Metrangolo, S, Montalbano, LM, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Marmo, Riccardo, Soncini, Marco, Bucci, Cristina, and Zullo, Angelo

Published
2021
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4. Derivation and validation of Re.Co.De death score risk in patients with acute nonvariceal upper GI bleeding

Author

Riccardo Marmo, Marco Soncini, Cristina Bucci, Vincenzo Occhipinti, Lucienne Pellegrini, Angelo Zullo, Amitrano L, Andriulli A, Annese V, Baldassarre G, Bargiggia S, Balzano A, Bazzoli F, Bennato R, Bianco M A, Bizzotto A, Boarino V, Bonanomi AG, Borgheresi P, Bresci G, Buffoli F, Buscarini E, Castrignanò G, Cavallaro LG, Cesaro P, Chirico A, Cipolletta F, Cipolletta L, Conigliaro R, Conte D, Costamagna G, D’ Amico G, De Fanis C, De Filippo FR, de Franchis R, Dell‘ Era A, De Nigris F, De Matthaeis M, Di Giorgio P, Di Giulio E, Esposito P, Ferraris L, Filippino A, Franceschi M, Furio L, Germana B, Grassia R, Imperiali G, Lamanda R, Lauri A, Londoni C, Mangiafico S, Manno M, Marmo C, Meroni R, Metrangolo S, Montalbano L. M, Napolitano G, Nucci A, Orsini L, Parente F, Parravicini M, Paterlini A, Pumpo R, Purita L, Repici A, Riccioni ME, Russo A, Segato S, Sorrentino I, Spinzi G, Spotti D, Tortora A, Triossi O, Zagari RM, and Zambelli A

Subjects
Cohort Studies, Area Under Curve, Acute Disease, Gastroenterology, Humans, Radiology, Nuclear Medicine and imaging, Gastrointestinal Hemorrhage, Prognosis, Risk Assessment, Severity of Illness Index
Abstract

Scores in upper GI bleeding (UGIB) are used to stratify death risk and need for hospitalization at admission, but a tool that incorporates dynamic changes during the hospital stay is lacking. We aimed to develop a death risk score that considers changes in clinical status during hospitalization and compare its performance with existing ones.A multicenter cohort study enrolling patients with UGIB in 50 Italian hospitals from January 2014 to December 2015 was conducted. Data were collected and used to develop a risk score using logistic regression analyses. Performance curves (area under the receiver-operating characteristic [AUROC] curves), sensitivities, specificities, positive and negative predictive values, and outcomes classified as low, intermediate, and high death risk were calculated. The score's performance was externally validated and then compared with other scores.We included 1852 patients with nonvariceal UGIB in the development cohort and 912 in the validation cohorts. The new score, which we named the Re.Co.De (rebleeding-comorbidities-deteriorating) score, included 10 variables depicting the changes in clinical conditions while in the hospital. The mortality AUROC curves were .93 (95% confidence interval, .91-.96) in the derivation cohort and .94 (95% confidence interval, .91-.98) in validation cohort. In a comparison of AUROC curves with other scores, the new score showed a significant performance compared with pre- and postendoscopy scores. Patients with low and high scores had 30-day mortality rates of .001% and 48.2%, respectively.The Re.Co.De score has a higher performance for predicting mortality in patients with UGIB compared with other scores, correctly identifying patients at low and high death risk while in the hospital through a dynamic re-evaluation of clinical status.

Published
2021

5. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Marmo, Riccardo, primary, Soncini, Marco, additional, Bucci, Cristina, additional, Zullo, Angelo, additional, Amitrano, L, additional, Anderloni, A, additional, Andriulli, A, additional, Annese, V, additional, Baldassarre, G, additional, Bargiggia, S, additional, Bazzoli, F, additional, Bennato, R, additional, Bianco, MA, additional, Bizzotto, A, additional, Boarino, V, additional, Bonanomi, AG, additional, Borgheresi, P, additional, Bresci, G, additional, Buffoli, F, additional, Buscarini, E, additional, Castrignanò, G, additional, Cavallaro, LG, additional, Cesaro, P, additional, Chirico, A, additional, Cipolletta, F, additional, Cipolletta, L, additional, Conigliaro, R, additional, Conte, D, additional, Costamagna, G, additional, Covello, F, additional, D'Amico, G, additional, De-Fanis, C, additional, De-Filippo, FR, additional, de-Franchis, R, additional, Dell‘Era, A, additional, De Nigris, F, additional, De-Matthaeis, M, additional, Di-Giorgio, P, additional, Di-Giulio, E, additional, Esposito, P, additional, Ferraris, L, additional, Filippino, A, additional, Franceschi, M, additional, Furio, L, additional, Germana', B, additional, Grassia, R, additional, Imperiali, G, additional, Lamanda, R, additional, Lauri, A, additional, Londoni, C, additional, Mangiafico, S, additional, Manno, M, additional, Marmo, C, additional, Merighi, A, additional, Meroni, R., additional, Metrangolo, S, additional, Montalbano, LM, additional, Napolitano, G, additional, Nucci, A, additional, Orsini, L, additional, Parente, F, additional, Parravicini, M, additional, Paterlini, A, additional, Pumpo, R, additional, Purita, L, additional, Repici, A, additional, Riccioni, ME, additional, Russo, A, additional, Segato, S, additional, Sorrentino, I, additional, Spinzi, G, additional, Spotti, D, additional, Tortora, A, additional, Tomba, C, additional, Triossi, O, additional, Zagari, RM, additional, and Zambelli, A, additional

Published
2021
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6. T01.01.7 THE USE OF A SPECIALIZED BLEEDING-MANAGEMENT TEAM HAD NO IMPACT ON MORTALITY FOR ACUTE UPPER GASTROINTESTINAL BLEEDING: AN ITALIAN PROSPECTIVE MULTICENTER COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Marmo, C., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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7. OC.10.1 THE USE OF PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS (PPIS) HAD NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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9. OC.11.5 TRIGGER AND TARGET TRANSFUSION STRATEGY IN PATIENTS WITH NON-VARICEAL ACUTE UPPER GASTROINTESTINAL BLEEDING (NV-AUGIB): A PROSPECTIVE MULTICENTRE OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Spada, C., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2019
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10. OC.14.2 PREDICTIVE FACTORS OF MORTALITY IN ACUTE GASTROINTESTINAL BLEEDING IN ITALY (AUGIB): A NEW PRE-ENDOSCOPY PROGNOSTIC MODEL FROM A MULTICENTER STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Eera, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2018
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13. P.10.8: Mortality from Acute Upper Gastrointestinal Bleeding (UGIB): The Role of the Organizational and Health Care Course: A Prospective Multicentre Observational Study in Italy

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, F., additional, Orsini, L., additional, Bennato, R., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Zingone, F., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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14. P.10.1: Transfusion Strategy and Death Risk in Patients with Acute Non-Variceal Upper Gastro Intestinal Bleeding (NV-UGIB) in Italy: A Prospective Multicenter Observational Study

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Mastrangelo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Zingone, F., additional, Lamanda, R., additional, Lauri, R., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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15. P.10.3: Mortality in Upper Gastrointestinal Bleeding in Italy: Data from National Survey

Author

Soncini, M., primary, Marmo, R., additional, Conte, D., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Tomba, C., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, and Balzano, A., additional

Published
2017
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16. P.10.10: Mortality Causes from Acute Upper Gastrointestinal Bleeding: A Prospective Multicentre Observational Study

Author

Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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17. P.10.9: Outpatient Management of Patients with Glasgow-Blatchford Bleeding Score Low-Risk Upper-Gastrointestinal Hemorrhage: A Multicenter Validation Study in Italy

Author

Marmo, R., primary, Soncini, M., additional, Orsini, L., additional, Cipolletta, F., additional, Bennato, R., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional

Published
2017
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18. Gastrointestinal hormones in acute viral hepatitis

Author

CUOMO, ROSARIO, TACCONE W, PANICO G, IAQUINTO G, PUMPO R, MANZILLO G, BUDILLON G., BUDILLON G., R. CUOMO, TACCONE W., PANICO G., IAQUINTO G., PUMPO R., MANZILLO G., Cuomo, Rosario, Taccone, W, Panico, G, Iaquinto, G, Pumpo, R, Manzillo, G, and Budillon, G.

Subjects
acute viral hepatiti, gastroeintestinal peptide, FEEDBACK-REGULATION
Abstract

The liver affects the release and clearance of many hormones, but the interactions between gastrointestinal peptides and liver function have yet to be established. The aim of this study was to evaluate by RIA the serum levels of glucagon, insulin, gastrin, vasoaetive intestinal peptide, gastrin-releasing peptide-GRP, neurotensin, cholecystokinin-CCK, secretin and motilin during acute hepatic cytonecrosis and during liver regeneration in man. The study was performed in ten patients with viral hepatitis (8 virus A and 2 virus B) in the acute phase (alanine transaminase-ALT = 3073 _+ 739 U/L; mean + SEM), and 52 days after the initial evaluation, during clinical and biochemical recovery (ALT = 77+ 26). Only serum GRP and CCK were significantly increased (about 100%; p

Published
1996

19. P.15.8 POOR OUTCOME FROM ACUTE UPPER GASTROINTESTINAL BLEEDING IN PATIENTS WITH LIVER CIRRHOSIS: A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Orsini, L., additional, Guardascione, M., additional, Amitrano, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Maringhi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Gasparini, P., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, Rotondano, G., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Maringhini, A., additional, Politi, F., additional, Di Giorgio, P., additional, Pumpo, R., additional, Martorano, M., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Balzano, A., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, and De Franchis, R., additional

Published
2016
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20. P.15.9 TRANSFUSION STRATEGY AND DEATH RISK IN PATIENTS WITH ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING (NV-UGIB) IN ITALY: A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Maringhi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, Rotondano, G., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Di Giorgio, P., additional, Politi, F., additional, Pumpo, R., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Balzano, A., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, Gasparini, P., additional, and De Franchis, R., additional

Published
2016
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21. P.15.3 INCREASED PERFORMANCE OF AN UPDATED ROCKALL SCORE IN ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING: A PROSPECTIVE MULTICENTRE ITALIAN STUDY

Author

Marmo, R., primary, Soncini, M., additional, Cipolletta, L., additional, Parente, F., additional, Paterlini, A., additional, Bennato, R., additional, Cipolletta, F., additional, Amitrano, L., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Dell'Era, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Spinzi, G., additional, Imperiali, G., additional, Merighi, A., additional, Boarino, V., additional, Bresci, G., additional, Metrangolo, S., additional, Bucci, C., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Masci, E., additional, Marin, R., additional, Antoniazzi, S., additional, Ferraris, L., additional, Repici, A., additional, Andreloni, A., additional, Bianco, M.A., additional, De Matthaeis, M., additional, Lauri, A., additional, De Fanis, C., additional, Borgheresi, P., additional, De Stefano, S., additional, Lamanda, R., additional, Furio, L., additional, Russo, A., additional, Maringhini, A., additional, Politi, F., additional, Di Giorgio, P., additional, Pumpo, R., additional, Martorano, M., additional, Triossi, O., additional, Coccia, G., additional, Montalbano, L.M., additional, Zagari, R.M., additional, Buscarini, E., additional, Conte, D., additional, D'Amico, G., additional, Di Giulio, E., additional, Balzano, A., additional, Gasparini, P., additional, Rotondano, G., additional, and De Franchis, R., additional

Published
2016
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24. Liver nicotinamide methylation: N-methylnicotinamide-transferase expression in cirrhosis

Author

PUMPO R, BUONO P, SALVATORE F, WEINSHILBOUM R, BUDILLON G., CUOMO, ROSARIO, Pumpo, R, Buono, P, Cuomo, Rosario, Salvatore, F, Weinshilboum, R, and Budillon, G.

Subjects
nicotinamide methylation, cirrhosis, N-methylnicotinamide-transferase
Abstract

Nicotinamide (NA) methylation followed by urinary excretion of Nvmethylnicotinamide (NMN) has been shown to be increased in cirrhotic patients under basal conditions and after NA oral loading in spite of the well known derangement of overall methylation processes during hepatic failure . Such a finding could depend on induction and activity increase of the specific hepatic enzyme nicotinamide N-methyltransferase (NNMT). Therefore we studied by Western blot analysis with polyclonal anti-NNMT antibody the expression ofNNMT in liver biopsies of 13 normal control s (5M. mean age 53 y) and 37 patients with liver diseases. 25 (14M, mean age 43 y) with C virus chronic hepatitis and 12 (9M. mean age 43 y) with liver cirrhosis (8 Child A; 4 B). Statistical analysis was performed with ANOVA and post-test for linear trend. Hepatic NNMT expression (as a ratio to a reference value) was shown to progressively decrease. with a significant {p

Published
2000

30. Early satiety and gastric emptying in dyspepsia

Author

CUOMO, ROSARIO, SARNELLI, GIOVANNI, GRASSO R, ALFIERI M, PUMPO R, TACK J, BUDILLON G., Cuomo, Rosario, Sarnelli, Giovanni, Grasso, R, Alfieri, M, Pumpo, R, Tack, J, and Budillon, G.

Subjects
gastric emptying, Early satiety, dyspepsia
Published
1999

31. Esophageal manometry in asymptomatic hiatal hernia

Author

CUOMO, ROSARIO, SARNELLI G, ALFIERI M, PUMPO R, GRASSO R, BUDILLON G., Cuomo, Rosario, Sarnelli, G, Alfieri, M, Pumpo, R, Grasso, R, and Budillon, G.

Abstract

Prescelto per la discussione in aula

Published
1997

41. Nicotinamide methylation and hepatic energy reserve

Author

CUOMO, ROSARIO, SARNELLI, GIOVANNI, PUMPO R, BUDILLON G., Cuomo, Rosario, Pumpo, R, Sarnelli, Giovanni, and Budillon, G.

Subjects
Nicotinamide methylation
Abstract

In liver diseases the reduction of hepatic energy reserve may affect many metabolic pathways that require ATPR e.g. the synthesis of pyridine nucleotides from nicotinamide (NAM). When exogenous NAM is poorly utilized in this synthesis, it follows a dissipative metabolic pathway and is excreted in urine as N-methyinicotinamide (NMN). Recently we reported a significant increase of NMN production and excretion in cirrhotic patients in basal condition and after NAM oral load. The aim of this study was to verify NAM methylation in relation to liver content of ATP and glycogen during rat liver in vitro perfusion with or without metabolic stress. The stress was obtained by a 15 min delay in Krebs medium perfusion of isolated liver. The metabolic stress significantly reduced the liver content of ATP The production of NMN in the stressed rat liver is significantly higher than in normal liver. The NAM liver methylation is inversely related to ATP (r = -0.74; p < 0.01) and glycogen (r = -0.53; p < 0.05) levels. In conclusion this study suggests that the increase of NMN production in cirrhotic patients may depend on the energy crisis of liver cell

Published
1994

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