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268 results on '"Puls, M."'

9. Aortic Valve Calcification And Myocardial Fibrosis Determine Outcome Following Transcatheter Aortic Valve Replacement: Insights From Cardiovascular Computed Tomography And Endomyocardial Biopsies.

Author

Evertz, R., primary, Hub, S., additional, Beuthner, B., additional, Backhaus, S., additional, Lange, T., additional, Toischer, K., additional, Seidler, T., additional, Lotz, J., additional, Kowallick, J., additional, Puls, M., additional, Zeisberg, E., additional, Hasenfuß, G., additional, and Schuster, A., additional

Published
2021
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12. Real-time cardiovascular magnetic resonance tissue characterisation in patients undergoing transcatheter aortic valve replacement

Author

Backhaus, SJ, primary, Lange, T, additional, Beuthner, BE, additional, Topci, R, additional, Wang, X, additional, Kowallick, JT, additional, Lotz, J, additional, Seidler, T, additional, Toischer, K, additional, Zeisberg, EM, additional, Puls, M, additional, Jacobshagen, C, additional, Uecker, M, additional, Hasenfus, G, additional, and Schuster, A, additional

Published
2021
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14. Real-time cardiac magnetic resonance tissue characterisation for fibrosis assessment in aortic stenosis

Author

Backhaus, S.J, primary, Lange, T, additional, Beuthner, B.E, additional, Topci, R, additional, Wang, X, additional, Kowallick, J.T, additional, Lotz, J, additional, Seidler, T, additional, Toischer, K, additional, Zeisberg, E.M, additional, Puls, M, additional, Jacobshagen, C, additional, Uecker, M, additional, Hasenfus, G, additional, and Schuster, A, additional

Published
2020
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17. Midterm outcomes of LAA occlusion with the AMPLATZER Cardiac Plug and AMPLATZER Amulet devices in a high-risk cohort

Author

Tichelbaecker, Tobias, Scherner, L., Puls, M., Schillinger, W., Adler, C., Baldus, S., Jacobshagen, C., Huenlich, M., Tichelbaecker, Tobias, Scherner, L., Puls, M., Schillinger, W., Adler, C., Baldus, S., Jacobshagen, C., and Huenlich, M.

Abstract

LAA occlusion has become a favourable option in patients with atrial fibrillation not eligible for oral anticoagulation therapy. Proof of effectiveness of LAA closure devices in a midterm follow-up period. This retrospective single-center cohort study analysed outcome in patients treated with AMPLATZER Cardiac Plug or AMPLATZER Amulet device. A standardized follow-up by phone call focusing on data of death, stroke and bleeding events was performed. Routine antiplatelet strategy was DAPT for 3 months post procedural. 212 patients (mean age 77 +/- 6 years) were included. Follow up was performed in 197 (93%) patients. Patients were at high risk for thromboembolic or bleeding events (prior stroke/TIA 29%; prior bleeding 54%. Overall, there was a mean follow-up period of 1244.2 days (+/- 756.7) and a total of 674 patient years. We observed 25 events later than day 8 post procedure. We were able to demonstrate a high effectiveness of the AMPLATZER Cardiac Plug/AMPLATZER Amulet devices regarding the prevention of stroke and bleedings in a high-risk real-world cohort during a midterm follow-up period. Overall, we observed remarkably lower rates of stroke and bleedings as predicted with CHA(2)DS(2)-VASc and HASBLED scores.

Published
2020

20. P4730Underweight is associated with unfavourable short- and long-term outcomes after MitraClip therapy: a body mass index derived subgroup analysis of the German Transcatheter Mitral Valve Interventions (

Author

Kalbacher, D, primary, Tigges, E P, additional, Boekstegers, P, additional, Puls, M, additional, Plicht, B, additional, Eggebrecht, H, additional, Nickenig, G, additional, Von Bardeleben, R S, additional, Zuern, C S, additional, Franke, J, additional, Sievert, H, additional, Ouarrak, T, additional, Senges, J, additional, and Lubos, E, additional

Published
2019
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21. Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure

Author

Huenlich, M., Lubos, E., Beuthner, B. E., Puls, M., Bleckmann, A., Beissbarth, T., Tichelbaecker, T., Rudolph, V., Baldus, S., Schaefer, U., Treede, H., Von Bardeleben, R. S., Blankenberg, S., Schillinger, W., Huenlich, M., Lubos, E., Beuthner, B. E., Puls, M., Bleckmann, A., Beissbarth, T., Tichelbaecker, T., Rudolph, V., Baldus, S., Schaefer, U., Treede, H., Von Bardeleben, R. S., Blankenberg, S., and Schillinger, W.

Abstract

Positive results of MitraClip in terms of improvement in clinical and left ventricular parameters have been described in detail. However, long-term effects on secondary pulmonary hypertension were not investigated in a larger patient cohort to date. 70 patients with severe mitral regurgitation, additional pulmonary hypertension, and right heart failure as a result of left heart disease were treated in the heart centers Hamburg and Gottingen. Immediately after successful MitraClip implantation, a reduction of the RVOT diameter from 3.52 cm to 3.44 cm was observed reaching a statistically significant value of 3.39 cm after 12 months. In contrast, there was a significant reduction in the velocity of the tricuspid regurgitation (TR) from 4.17 m/s to 3.11 m/s, the gradient of the TR from 48.5 mmHg to 39.3 mmHg, and the systolic pulmonary artery pressure (PAPsyst) from 58.6 mmHg to 50.0 mmHg. This decline continued in the following months (V-max TR 3.09 m/s, peak TR 38.6 mmHg, and PAPsyst 47.4 mmHg). The tricuspid annular plane systolic excursion (TAPSE) increased from 16.5 mm to 18.9 mm after 12 months. MitraClip implantation improves pulmonary artery pressure, tricuspid regurgitation, and TAPSE after 12 months. At the same time, there is a decrease in the RVOT diameter without significant changes in other right ventricular and right atrial dimensions.

Published
2018

24. Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure

Author

Hünlich, M., primary, Lubos, E., additional, Beuthner, B. E., additional, Puls, M., additional, Bleckmann, A., additional, Beißbarth, T., additional, Tichelbäcker, T., additional, Rudolph, V., additional, Baldus, S., additional, Schäfer, U., additional, Treede, H., additional, Von Bardeleben, R. S., additional, Blankenberg, S., additional, and Schillinger, W., additional

Published
2018
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25. P6327Prognostic value of pre-procedural 6 minute walk test in patients undergoing MitraClip implantation - insights from the German mitral valve interventions registry

Author

Ledwoch, J., primary, Puls, M., additional, Lubos, E., additional, Boekstegers, P., additional, Von Bardeleben, R.S., additional, Ouarrak, T., additional, Butter, C., additional, Zuern, C., additional, Bekeredjian, R., additional, Nickenig, G., additional, Eggebrecht, H., additional, Senges, J., additional, Schillinger, W., additional, and Sievert, H., additional

Published
2017
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33. Navigierte Stellungskorrektur des Azetabulums bei Periazetabulärer Umstellungsosteotomie – eine Computer-assistierte Kadaverstudie

Author

Ecker, TM, Puls, M, Bastian, J, Keel, M, Tannast, M, and Siebenrock, KA

Subjects
ddc: 610, Genauigkeit, Becken, 610 Medical sciences, Medicine, Osteotomie, Navigation
Abstract

Fragestellung: Die periazetabuläre Umstellungsosteotomie (PAO) ist eine akzeptierte Behandlungsmethode bei kongenitaler Hüftdysplasie. Neben den Schwierigkeiten bei der präoperativen Planung ist insbesondere die intraoperative Stellungskorrektur des Azetabulums aufgrund der Patientenlagerung,[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2012)

Published
2012
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40. The lid is a structural and functional determinant of lipase activity and selectivity

Author

Secundo, F, Carrea, G, Tarabiono, C, Gatti Lafranconi, P, Brocca, S, Lotti, M, Jaeger, K, Puls, M, Eggert, T, Jaeger, KE, Eggert, T., BROCCA, STEFANIA, LOTTI, MARINA, Secundo, F, Carrea, G, Tarabiono, C, Gatti Lafranconi, P, Brocca, S, Lotti, M, Jaeger, K, Puls, M, Eggert, T, Jaeger, KE, Eggert, T., BROCCA, STEFANIA, and LOTTI, MARINA

Abstract

In several lipases access to the enzyme active site is regulated by the position of a mobile structure named the lid. The role of this region in modulating lipase function is reviewed in this paper analysing the results obtained with three different recombinant lipases modified in the lid sequence: Candida rugosa lipase isoform 1 (CRL1), Pseudomonas fragi lipase (PFL) and Bacillus subtilis lipase A (BSLA). A CRL chimera enzyme obtained by replacing its lid with that of another C. rugosa lipase isoform (CRL1LID3) was found to be affected in both activity and enantioselectivity in organic solvent. Variants of the PFL protein in which three polar lid residues were replaced with amino acids strictly conserved in homologous lipases displayed altered chain length preference profile and increased thermostability. On the other hand, insertion of lid structures from structurally homologous enzymes into BSLA, a lipase that naturally does not possess such a lid structure, caused a reduction in the enzyme activity and an altered substrate specificity. These results strongly support the concept that the lid plays an important role in modulating not only activity but also specifity, enantioselectivity and stability of lipase enzymes. (c) 2006 Elsevier B.V. All rights reserved.

Published
2006

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