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2 results on '"Pulmonary artery function"'

1. Echinacoside prevents hypoxic pulmonary hypertension by regulating the pulmonary artery function

Author

Xiangyun Gai, Pengcheng Lin, Yanfeng He, Dianxiang Lu, Zhanqiang Li, Yongxin Liang, Yuhua Ma, Nanjia Cairang, Mingli Zuo, Yi Bao, Zhaxi Gazang, and Xuehua Wu

Subjects
Echinacoside, Hypoxic pulmonary hypertension, Pulmonary artery function, Endothelium, Smooth muscle layer, Therapeutics. Pharmacology, RM1-950
Abstract

Hypoxic pulmonary hypertension (HPH) is a progressive and irreversible disease that reduces survival. Echinacoside is a phenylethanoid glycoside from Tibetan herbs known for its vasorelaxant effect and for inhibiting the proliferation of rat pulmonary arterial smooth muscle cells. This study aimed to investigate the effect of echinacoside on HPH. Sprague Dawley rats were housed in a hypobaric hypoxia chamber (4500 m) for 28 days to obtain the HPH model. Echinacoside (3.75, 7.5, 15, 30 and 40 mg/kg) was administered by intraperitoneal injection from the 1st to the 28th day. The mean pulmonary artery pressure (mPAP), right ventricular hypertrophy index, hemoglobin, hematocrit, red blood cell concentration and morphological change of pulmonary arteries were evaluated. Vascular perfusion assay was used to assess the pulmonary artery function. Echinacoside reduced mPAP, hemoglobin, hematocrit, right ventricular hypertrophy index and mean wall thickness% of pulmonary arteries in HPH rats. It significantly increased maximum vasoconstriction percentage of pulmonary arteries induced by noradrenaline in a dose-dependent manner. In addition, it improved the responsiveness of pulmonary arteries to acetylcholine and sodium nitroprusside. Therefore, Echinacoside might be an effective treatment against HPH, since it regulated pulmonary artery endothelium and smooth muscle layer function and improved the remodeling of pulmonary artery.

Published
2020
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2. Echinacoside prevents hypoxic pulmonary hypertension by regulating the pulmonary artery function

Author

Mingli Zuo, Yanfeng He, Yi Bao, Xiangyun Gai, Yongxin Liang, Pengcheng Lin, Dianxiang Lu, Gazang Zhaxi, Yuhua Ma, Cairang Nanjia, Zhanqiang Li, and Xuehua Wu

Subjects
0301 basic medicine, Male, Vasodilator Agents, Hematocrit, Rats, Sprague-Dawley, chemistry.chemical_compound, 0302 clinical medicine, Glycosides, Hypoxia, medicine.diagnostic_test, medicine.anatomical_structure, Echinacoside, Pulmonary artery function, Cardiology, Molecular Medicine, Sodium nitroprusside, medicine.symptom, Injections, Intraperitoneal, Smooth muscle layer, medicine.drug, medicine.medical_specialty, Endothelium, Hypertension, Pulmonary, In Vitro Techniques, Pulmonary Artery, Vascular Remodeling, 03 medical and health sciences, Right ventricular hypertrophy, medicine.artery, Internal medicine, medicine, Animals, Hypoxic pulmonary hypertension, Pharmacology, Dose-Response Relationship, Drug, business.industry, lcsh:RM1-950, medicine.disease, Pulmonary hypertension, Disease Models, Animal, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, chemistry, Vasoconstriction, Pulmonary artery, business, 030217 neurology & neurosurgery, Phytotherapy
Abstract

Hypoxic pulmonary hypertension (HPH) is a progressive and irreversible disease that reduces survival. Echinacoside is a phenylethanoid glycoside from Tibetan herbs known for its vasorelaxant effect and for inhibiting the proliferation of rat pulmonary arterial smooth muscle cells. This study aimed to investigate the effect of echinacoside on HPH. Sprague Dawley rats were housed in a hypobaric hypoxia chamber (4500 m) for 28 days to obtain the HPH model. Echinacoside (3.75, 7.5, 15, 30 and 40 mg/kg) was administered by intraperitoneal injection from the 1st to the 28th day. The mean pulmonary artery pressure (mPAP), right ventricular hypertrophy index, hemoglobin, hematocrit, red blood cell concentration and morphological change of pulmonary arteries were evaluated. Vascular perfusion assay was used to assess the pulmonary artery function. Echinacoside reduced mPAP, hemoglobin, hematocrit, right ventricular hypertrophy index and mean wall thickness% of pulmonary arteries in HPH rats. It significantly increased maximum vasoconstriction percentage of pulmonary arteries induced by noradrenaline in a dose-dependent manner. In addition, it improved the responsiveness of pulmonary arteries to acetylcholine and sodium nitroprusside. Therefore, Echinacoside might be an effective treatment against HPH, since it regulated pulmonary artery endothelium and smooth muscle layer function and improved the remodeling of pulmonary artery.

Published
2020

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