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262 results on '"Pullakhandam, Raghu"'

11. Eggs for Improving Nutrition, cognitive development and reducing linear growth retardation among Infants and young Children (ENRICH): protocol of an egg supplementation trial among children aged 9–18 months in Hyderabad, India

Author

Banjara, Santosh Kumar, primary, Challa, Sai Ram, additional, Augustine, Little Flower, additional, Dasi, Teena, additional, Madhari, Radhika, additional, Fernandez Rao, Sylvia, additional, Palika, Ravindranadh, additional, Pullakhandam, Raghu, additional, Kalashikam, Rajender Rao, additional, Kumar, Ramachandrappa Naveen, additional, Palepu, Dharani Pratyusha, additional, Chilumula, Monica, additional, Selvaraj, Kiruthika, additional, Gopinath, Preethi, additional, Davies-Kershaw, Hilary, additional, Jobarteh, Modou Lamin, additional, Haggarty, Paul, additional, Heffernan, Claire, additional, Ferguson, Elaine, additional, and Kulkarni, Bharati, additional

Published
2024
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12. Anthropometric, biochemical, dietary, morbidity and well-being assessments in women and children in Indonesia, India and Senegal: a UKRI GCRF Action Against Stunting Hub protocol paper

Author

Davies-Kershaw, Hilary, primary, Fahmida, Umi, additional, Htet, Min Kyaw, additional, Kulkarni, Bharati, additional, Faye, Babacar, additional, Yanti, Dwi, additional, Shinta, Dewi, additional, Zahra, Nur L, additional, Angelin, Tiffany C, additional, Madhari, Radhika, additional, Pullakhandam, Raghu, additional, Palika, Ravindranadh, additional, Dasi, Teena, additional, Fernandez Rao, Sylvia, additional, Banjara, Santosh Kumar, additional, Selvaraj, Kiruthika, additional, Palepu, Dharani Pratyusha, additional, Yadev, Dinesh, additional, Diouf, Saliou, additional, Lopez-Sall, Philomene, additional, Diallo, Babacar, additional, Mouissi, Princillia, additional, Fall, Sally, additional, Diallo, Ibrahima, additional, Djigal, Aicha, additional, Immerzeel, Tabitha D Van, additional, Tairou, Fassia, additional, Diop, Assana, additional, Pradeilles, Rebecca, additional, Strout, Sara, additional, Momo Kadia, Benjamin, additional, Tata, Darius Tetsa, additional, Jobarteh, Modou Lamin, additional, Allen, Stephen, additional, Walker, Alan, additional, Webster, Joanne P, additional, Haggarty, Paul, additional, Heffernan, Claire, additional, and Ferguson, Elaine, additional

Published
2024
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21. Exome Analysis Identified a Novel Mutation in the RBP4 Gene in a Consanguineous Pedigree with Retinal Dystrophy and Developmental Abnormalities

Author

Cukras, Catherine, Gaasterland, Terry, Lee, Pauline, Gudiseva, Harini V, Chavali, Venkata RM, Pullakhandam, Raghu, Maranhao, Bruno, Edsall, Lee, Soares, Sandra, Reddy, G Bhanuprakash, Sieving, Paul A, and Ayyagari, Radha

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurodegenerative, Neurosciences, Clinical Research, Rare Diseases, Nutrition, Genetics, Eye Disease and Disorders of Vision, Aetiology, 2.1 Biological and endogenous factors, Eye, Adult, Base Sequence, Consanguinity, Developmental Disabilities, Electroretinography, Exome, Female, Humans, Male, Middle Aged, Mutation, Pedigree, Phenotype, Prealbumin, Retinal Dystrophies, Retinol-Binding Proteins, Plasma, Visual Fields, Vitamin A, General Science & Technology
Abstract

Retinitis Pigmentosa (RP) is a common form of retinal degeneration characterized by photoreceptor degeneration and retinal pigment epithelium (RPE) atrophy causing loss of visual field and acuities. Exome sequencing identified a novel homozygous splice site variant (c.111+1G>A) in the gene encoding retinol binding protein 4 (RBP4). This change segregated with early onset, progressive, and severe autosomal recessive retinitis pigmentosa (arRP) in an eight member consanguineous pedigree of European ancestry. Additionally, one patient exhibited developmental abnormalities including patent ductus arteriosus and chorioretinal and iris colobomas. The second patient developed acne from young age and extending into the 5(th) decade. Both patients had undetectable levels of RBP4 in the serum suggesting that this mutation led to either mRNA or protein instability resulting in a null phenotype. In addition, the patients exhibited severe vitamin A deficiency, and diminished serum retinol levels. Circulating transthyretin levels were normal. This study identifies the RBP4 splice site change as the cause of RP in this pedigree. The presence of developmental abnormalities and severe acne in patients with retinal degeneration may indicate the involvement of genes that regulate vitamin A absorption, transport and metabolism.

Published
2012

26. Haemoglobin diagnostic cut-offs for anaemia in Indian women of reproductive age

Author

Ghosh, Santu, primary, Palika, Ravindranadh, additional, Dasi, Teena, additional, Varshney, Rajeev, additional, Prasannanavar, Devraj, additional, Gupta, Sourav, additional, Chitikineni, Annapurna, additional, Banjara, Santosh, additional, Pullakhandam, Raghu, additional, Thomas, Tinku, additional, Sachdev, Harshpal, additional, Kurpad, Anura, additional, and Kulkarni, Bharati, additional

Published
2023
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31. Prevalence of Vitamin B 12 and Folate Deficiencies in Indian Children and Adolescents.

Author

Shalini, Tattari, Pullakhandam, Raghu, Ghosh, Santu, Kulkarni, Bharati, Rajkumar, Hemalatha, Sachdev, Harshpal S., Kurpad, Anura V., and Reddy, Geereddy Bhanuprakash

Abstract

Deficiencies of vitamin B12 (B12) and folate (FA) are of particular interest due to their pleiotropic role in 1-carbon metabolism. In addition to adverse birth outcomes, deficiencies of B12 and FA, or an imbalance in FA/B12 status, are linked to metabolic disorders. Indian diets that are predominantly plant food-based could be deficient in these vitamins, but there are no national estimates of the prevalence of B12 and FA deficiency in Indian children and adolescents, nor their associations with age, sex and growth indicators. The recent Comprehensive National Nutrition Survey (CNNS-2016-18) provided estimates of the prevalence of B12 and FA deficiency at the national and state levels among preschool (1–4 years: 9976 and 11,004 children, respectively), school-age children (5–9 years: 12,156 and 14,125) and adolescents (10–19 years: 11,748 and 13,621). Serum B12 and erythrocyte FA were measured by the direct chemiluminescence method and their deficiency was defined using WHO cut-offs. The prevalence of B12 and FA deficiency was high among adolescents (31.0%, CI: 28.7–33.5 and 35.6%, CI: 33.1–8.2) compared to school-age (17.3%, CI: 15.4–19.3 and 27.6%, CI: 25.5–29.9) and preschool children (13.8%, CI: 11.7–16.2 and 22.8%, CI: 20.5–25.2, respectively). The prevalence of both B12 and FA deficiency was significantly higher by 8% and 5%, respectively, in adolescent boys compared to girls. There was no association between anthropometric undernutrition and B12 and FA deficiency. There was wide regional variation in the prevalence of B12 and FA deficiency, but no rural–urban differences were observed across all age groups. The national prevalence of B12 deficiency among preschool or school-age children was <20% (the cut-off that indicates a public health problem). However, FA deficiency in these age groups and both FA and B12 deficiencies in adolescents were >20%, warranting further investigation. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Physicochemical studies of sunflower oil based vitamin D nanoemulsions.

Author

Inapurapu, Santhi Priya, Pullakhandam, Raghu, Bodiga, Sreedhar, Yaduvanshi, Puneeta Singh, and Bodiga, Vijaya Lakshmi

Subjects
*VITAMIN D, *SUNFLOWER seed oil, *EDIBLE fats & oils, *SYNTHETIC lubricants, *TERNARY phase diagrams, *CHOLECALCIFEROL, *VITAMIN D receptors
Abstract

The cumulative scientific information available on the digestibility of cooking oils and their nutritive values has spurred interest in replacing synthetic oils with natural oils to encapsulate lipophilic bioactives in nanoemulsion form. Our aim was to design stable nanoemulsions that encapsulate maximum concentration of cholecalciferol (vitamin D3) into edible oil for improved stability and bioaccessibility. Among the four cooking oils tested, sunflower oil nanoemulsions formulated by a low energy method were found to be stable and highly miscible with Tween 85 and isopropanol (1:1) surfactant mixture. Mean droplet size of these nanoemulsions encapsulating 0.1–0.% (w/v) of cholecalciferol varied from 57.7 ± 1.9 to 158.13 ± 1.8 nm, and the ζ-potential maintained beyond −30 mV with entrapment efficiency ranging from 94.1% to 95.7%. Nanoemulsions were found to be stable over a period of 28 days upon storage at 4, 25, and 40 °C with no significant change in vitamin D3 content. Bioaccessibility studies using a simulated gastro-intestinal digestion model revealed release of 98% of the encapsulated vitamin D3. This method reported here to fabricate cooking oil based nanoemulsions for encapsulation of VD3 using simple formulations and inexpensive tools can have economic importance in therapeutic and food based approaches to enhance the quality of vitamin D nutrition. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Point-of-care Hb measurement in pooled capillary blood by a portable autoanalyser: comparison with venous blood Hb measured by reference methods in cross-sectional and longitudinal studies

Author

Dasi, Teena, primary, Palika, Ravindranadh, additional, Pullakhandam, Raghu, additional, Augustine, Little Flower, additional, Boiroju, Naveen Kumar, additional, Prasannanavar, Devraj J., additional, Pradhan, Anju Sinha, additional, Kurpad, Anura V., additional, Sachdev, Harshpal Singh, additional, and Kulkarni, Bharati, additional

Published
2021
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43. SARS-CoV-2 seroprevalence in the city of Hyderabad, India in early 2021

Author

Divya Tej Sowpati, P. Ravindranadh, Nimmathota Arlappa, Rakesh Mishra, M.V. Surekha, Pullakhandam Raghu, V. Mahesh Anumalla, Mahesh Kumar, P. Raghavendra, R. Sabarinathan, Karthik Bharadwaj Tallapaka, Avula Laxmaiah, Sarika, D. Chandra Kumar, S. Devendra, T. Santhosh Kumar, P. Uday Kumar, P. Devaraj, F. Sylvia, Jagjeevan Babu, Surabhi Srivastava, J. Srinivasa Rao, K. Rajender Rao, P.P.S. Blessy, Manoj Murekhar, Nalam Madhusudhan Rao, Deepak Kumar, B Naveen Kumar, Priya Singh, Paras Sharma, R. Ananthan, M. Santhos Kumar, Rajkumar Hemalatha, B. Santosh Kumar, Indrapal I. Meshram, G. Subba Rao, and Deepak Sharma

Subjects
education.field_of_study, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, Pandemic, Seroprevalence, Medicine, education, business, Demography
Abstract

BackgroundCOVID-19 emerged as a global pandemic in 2020, rapidly spreading to most parts of the world. The proportion of infected individuals in a population can be reliably estimated via sero-surveillance, making it a valuable tool for planning control measures. We conducted a serosurvey study to investigate SARS-CoV-2 seroprevalence in the urban population of Hyderabad at the end of the first wave of infections.MethodsThe cross-sectional survey conducted in January 2021 included males and females aged 10 years and above, selected by multi-stage random sampling. 9363 samples were collected from 30 wards distributed over 6 zones of Hyderabad and tested for antibodies against SARS-CoV-2 nucleocapsid antigen.ResultsOverall seropositivity was 54.2%, ranging from 50-60% in most wards. Highest exposure appeared to be among 30-39y and 50-59y olds, with women showing greater seropositivity. Seropositivity increased with family size, with only marginal differences among people with varying levels of education. Seroprevalence was significantly lower among smokers. Only 11% of the survey subjects reported any COVID-19 symptoms, while 17% had appeared for Covid testing.ConclusionOver half the city’s population was infected within a year of onset of the pandemic. However, ∼46% people were still susceptible, contributing to subsequent waves of infection.Highlights⍰National level serosurveys under-estimate localised prevalence in dense urban areas⍰SARS-CoV-2 seroprevalence in Hyderabad city was 54.2% after the first wave⍰A large proportion of the population remains at risk over a year into the pandemic

Published
2021

44. Perspective: When the cure might become the malady: the layering of multiple interventions with mandatory micronutrient fortification of foods in India

Author

Kurpad, Anura V, primary, Ghosh, Santu, additional, Thomas, Tinku, additional, Bandyopadhyay, Sulagna, additional, Goswami, Ravinder, additional, Gupta, Arun, additional, Gupta, Piyush, additional, John, Anjaly T, additional, Kapil, Umesh, additional, Kulkarni, Bharati, additional, Kuriyan, Rebecca, additional, Madan, Jagmeet, additional, Makkar, Sanchit, additional, Nair, Krishnapillai M, additional, Pullakhandam, Raghu, additional, Reddy, G Bhanuprakash, additional, Shah, Dheeraj, additional, and Sachdev, Harshpal S, additional

Published
2021
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46. Prevalence of Iron Deficiency and its Sociodemographic Patterning in Indian Children and Adolescents: Findings from the Comprehensive National Nutrition Survey 2016–18

Author

Kulkarni, Bharati, primary, Peter, Rajini, additional, Ghosh, Santu, additional, Pullakhandam, Raghu, additional, Thomas, Tinku, additional, Reddy, G Bhanuprakash, additional, Rajkumar, Hemalatha, additional, Kapil, Umesh, additional, Deb, Sila, additional, Johnston, Robert, additional, Agrawal, Praween K, additional, De Wagt, Arjan, additional, Kurpad, Anura V, additional, and Sachdev, Harshpal Singh, additional

Published
2021
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47. Prevalence of low serum zinc concentrations in Indian children and adolescents: findings from the Comprehensive National Nutrition Survey 2016–18

Author

Pullakhandam, Raghu, primary, Agrawal, Praween K, additional, Peter, Rajini, additional, Ghosh, Santu, additional, Reddy, G Bhanuprakash, additional, Kulkarni, Bharati, additional, Thomas, Tinku, additional, Kurpad, Anura V, additional, Sachdev, Harshpal S, additional, Porwal, Akash, additional, Khan, Nizamuddin, additional, Ramesh, Sowmya, additional, Acharya, Rajib, additional, Sarna, Avina, additional, Kapil, Umesh, additional, Rajkumar, Hemalatha, additional, De Wagt, Arjan, additional, Deb, Sila, additional, and Johnston, Robert, additional

Published
2021
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48. Point-of-care Hb measurement in pooled capillary blood by a portable autoanalyser: comparison with venous blood Hb measured by reference methods in cross-sectional and longitudinal studies.

Author

Dasi, Teena, Palika, Ravindranadh, Pullakhandam, Raghu, Augustine, Little Flower, Boiroju, Naveen Kumar, Prasannanavar, Devraj J., Pradhan, Anju Sinha, Kurpad, Anura V., Sachdev, Harshpal Singh, and Kulkarni, Bharati

Subjects
ANEMIA diagnosis, REFERENCE values, HEMOGLOBINS, VEINS, POINT-of-care testing, CAPILLARIES, CROSS-sectional method, IRON, IRON in the body, MEDICAL screening, AUTOMATION, RADIATION doses, ANEMIA, DISEASE prevalence, BLOOD testing, FOLIC acid, SENSITIVITY & specificity (Statistics), MEDICAL equipment, LONGITUDINAL method
Abstract

Population-based surveys commonly use point-of-care (POC) methods with capillary blood samples for estimating Hb concentrations; these estimates need to be validated by comparison with reference methods using venous blood. In a cross-sectional study in 748 participants (17–86 years, 708 women, Hb: 5·1 to 18·2 g/dl) from Hyderabad, India, we validated Hb measured from a pooled capillary blood sample by a POC autoanalyser (Horiba ABX Micros 60OT, Hb-C-AA) by comparison with venous blood Hb measured by two reference methods: POC autoanalyser (Hb-V-AA) and cyanmethemoglobin method (Hb-V-CM). These comparisons also allowed estimation of blood sample-related and equipment-related differences in the Hb estimates. We also conducted a longitudinal study in 426 participants (17–21 years) to measure differences in the Hb response to iron folate (IFA) treatment by the capillary blood POC method compared with the reference methods. In the cross-sectional study, Bland–Altman analyses showed trivial differences between source of blood (Hb-C-AA and Hb-V-AA; mean difference, limits of agreement: 0·1, −0·8 to 1·0 g/dl) and between analytical methods (Hb-V-AA and Hb-V-CM; mean difference, limits of agreement: < 0·1, −1·8 to 1·8 g/dl). Cross-sectional anaemia prevalence estimated using Hb-C-AA did not differ significantly from Hb-V-CM or Hb-V-AA. In the longitudinal study, the Hb increment in response to IFA intervention was not different when using Hb-C-AA (1·6 ± 1·7 g/dl) compared with Hb-V-AA (1·7 ± 1·7 g/dl) and Hb-V-CM (1·7 ± 1·7 g/dl). The pooled capillary blood–autoanalyzer method (Hb-C-AA) offers a practical and accurate way forward for POC screening of anaemia. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Prevalence of vitamin A deficiency and dietary inadequacy in Indian school-age children and adolescents

Author

Reddy, Geereddy Bhanuprakash, primary, Shalini, Tattari, additional, Ghosh, Santu, additional, Pullakhandam, Raghu, additional, Kumar, Boiroju Naveen, additional, Kulkarni, Bharati, additional, Laxmaiah, Avula, additional, Kapil, Umesh, additional, Deb, Sila, additional, Hemalatha, Rajkumar, additional, Kurpad, Anura V., additional, and Sachdev, Harshpal S., additional

Published
2021
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