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27. Occupational epidemiological study of workers in an acrylonitrile using factory with particular attention to cancers and birth defects.

Author

Czeizel AE, Szilvási R, Tímár L, and Puhō E

Subjects
Age Distribution, Case-Control Studies, Chemical Industry statistics & numerical data, Cohort Studies, Female, Humans, Hungary epidemiology, Infant, Newborn, Infant, Newborn, Diseases etiology, Male, Neoplasms chemically induced, Neoplasms diagnosis, Occupational Exposure statistics & numerical data, Odds Ratio, Pregnancy, Retrospective Studies, Sex Distribution, Acrylonitrile adverse effects, Hazardous Substances adverse effects, Infant, Newborn, Diseases epidemiology, Neoplasms epidemiology, Occupational Exposure adverse effects
Abstract

An occupational epidemiological study was organised among workers in an acrylonitrile using factory in Hungary. Of the 888 workers, 783 were included in the study and three groups were differentiated: Group A (N = 452) with direct and continuous exposure, Group B (N = 171) with direct but occasional exposure and Group C (N = 160) without direct exposure, as referent. There were two main objectives: to determine the occurrence of cancer in workers and congenital abnormalities in their liveborn infants. The study did not indicate a higher occurrence of cancer among workers: only one lung cancer patient was found, prostate cancer did not occur. Among congenital abnormalities, the group of specified multiple congenital abnormalities showed a higher rate than expected but characteristic defect-pattern was not found among seven multimalformed babies, though five had cardiovascular malformations. In conclusion, our study did not indicate the carcinogenic, mutagenic and teratogenic effect of acrylonitrile among workers using this chemical in the factory.

Published
2004
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