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6 results on '"Puga-Gómez, Rinaldo"'

1. Real-world effectiveness of the heterologous SOBERANA-02 and SOBERANA-Plus vaccine scheme in 2–11 years-old children during the SARS-CoV-2 Omicron wave in Cuba: a longitudinal case-population study

Author

Toledo-Romaní, María Eugenia, Valenzuela-Silva, Carmen, Montero-Díaz, Minerva, Iñiguez-Rojas, Luisa, Rodríguez-González, Meiby, Martínez-Cabrera, Mery, Puga-Gómez, Rinaldo, German-Almeida, Angel, Fernández-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, López-González, Lissette, Morales-Suárez, Ileana, Doroud, Delaram, Valdés-Balbín, Yury, García-Rivera, Dagmar, Van der Stuyft, Patrick, and Vérez-Bencomo, Vicente

Published
2024
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2. Open-label phase I/II clinical trial of SARS-CoV-2 receptor binding domain-tetanus toxoid conjugate vaccine (FINLAY-FR-2) in combination with receptor binding domain-protein vaccine (FINLAY-FR-1A) in children

Author

Mesa-Herrera, María Elena, García-Cristiá, Yarmila, Verdecia-Sánchez, Leonor, del Valle Rodríguez, Rafael, Oquendo-de la Cruz, Yudalvies, Álvarez-Montalvo, Daysi, Grillo-Fortún, Randy, López-González, Liset, Galindo, Omaida Fonte, Reyes-González, Yeseni, González-Álvarez, Ana Beatriz, Gorrita-Mora, Linet, Valera-Fernández, Rodrigo, Ontivero-Pino, Ivis, Martínez-Pérez, Marisel, Caballero-Gonzalez, Esperanza, Garcés-Hechavarría, Aniurka, Martínez-Bedoya, Dayle, Medina-Nápoles, Maite, Domínguez-Pentón, Yeney Regla, Cazañas-Quintana, Yadira, Barrios, Thais Fundora, Fernández, Diana R. Hernández, Bergado-Báez, Gretchen, Orosa-Vazquez, Ivette, Pi-Estopiñan, Franciscary, Díaz-Hernández, Marianniz, Cruz-Sui, Otto, Noa-Romero, Enrique, García-López, Arilia, Muro, Sandra Rivadereira, Baro-Roman, Gerardo, Puga-Gómez, Rinaldo, Ricardo-Delgado, Yariset, Rojas-Iriarte, Chaumey, Céspedes-Henriquez, Leyanis, Piedra-Bello, Misleidys, Vega-Mendoza, Dania, Pérez, Noelvia Pestana, Paredes-Moreno, Beatriz, Rodríguez-González, Meiby, Valenzuela-Silva, Carmen, Sánchez-Ramírez, Belinda, Rodríguez-Noda, Laura, Pérez-Nicado, Rocmira, González-Mugica, Raul, Hernández-García, Tays, Fundora-Barrios, Talía, Echevarría, Martha Dubet, Enriquez-Puertas, Juliet María, Infante-Hernández, Yenicet, Palenzuela-Díaz, Ariel, Gato-Orozco, Evelyn, Chappi-Estévez, Yanet, Francisco-Pérez, Julio Cesar, Suarez-Martinez, Miladi, Castillo-Quintana, Ismavy C., Fernandez-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, García-Vega, Yanelda, Toledo-Romani, María Eugenia, Doroud, Delaram, Biglari, Alireza, Valdés-Balbín, Yury, García-Rivera, Dagmar, and Vérez-Bencomo, Vicente

Published
2023
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3. A single dose of SARS-CoV-2 FINLAY-FR-1A vaccine enhances neutralization response in COVID-19 convalescents, with a very good safety profile: An open-label phase 1 clinical trial

Author

Chang-Monteagudo, Arturo, Ochoa-Azze, Rolando, Climent-Ruiz, Yanet, Macías-Abraham, Consuelo, Rodríguez-Noda, Laura, Valenzuela-Silva, Carmen, Sánchez-Ramírez, Belinda, Perez-Nicado, Rocmira, Hernández-García, Tays, Orosa-Vázquez, Ivette, Díaz-Hernández, Marianniz, García-García, María de los Ángeles, Jerez-Barceló, Yanet, Triana-Marrero, Yenisey, Ruiz-Villegas, Laura, Rodríguez-Prieto, Luis Dairon, Puga-Gómez, Rinaldo, Guerra-Chaviano, Pedro Pablo, Zúñiga-Rosales, Yaíma, Marcheco-Teruel, Beatriz, Rodríguez-Acosta, Mireida, Noa-Romero, Enrique, Enríquez-Puertas, Juliet, Porto-González, Delia, Fernández-Medina, Olivia, Valdés-Zayas, Anet, Chen, Guang-Wu, Herrera-Martínez, Luís, Valdés-Balbín, Yury, García-Rivera, Dagmar, and Verez-Bencomo, Vicente

Published
2021
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4. Comparative Immune Response after Vaccination with SOBERANA® 02 and SOBERANA® plus Heterologous Scheme and Natural Infection in Young Children

Author

Pérez-Nicado, Rocmira, primary, Massa, Chiara, additional, Rodríguez-Noda, Laura Marta, additional, Müller, Anja, additional, Puga-Gómez, Rinaldo, additional, Ricardo-Delgado, Yariset, additional, Paredes-Moreno, Beatriz, additional, Rodríguez-González, Meiby, additional, García-Ferrer, Marylé, additional, Palmero-Álvarez, Ilianet, additional, Garcés-Hechavarría, Aniurka, additional, Rivera, Daniel G., additional, Valdés-Balbín, Yury, additional, Vérez-Bencomo, Vicente, additional, García-Rivera, Dagmar, additional, and Seliger, Barbara, additional

Published
2023
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5. Comparative Immune Response after Vaccination with SOBERANA ® 02 and SOBERANA ® plus Heterologous Scheme and Natural Infection in Young Children.

Author

Pérez-Nicado, Rocmira, Massa, Chiara, Rodríguez-Noda, Laura Marta, Müller, Anja, Puga-Gómez, Rinaldo, Ricardo-Delgado, Yariset, Paredes-Moreno, Beatriz, Rodríguez-González, Meiby, García-Ferrer, Marylé, Palmero-Álvarez, Ilianet, Garcés-Hechavarría, Aniurka, Rivera, Daniel G., Valdés-Balbín, Yury, Vérez-Bencomo, Vicente, García-Rivera, Dagmar, and Seliger, Barbara

Subjects
MULTISYSTEM inflammatory syndrome, IMMUNE response, VACCINE effectiveness, IMMUNOLOGIC memory, VACCINATION of children, GRANZYMES, BACTERIAL vaccines
Abstract

(1) Background: In children, SARS-CoV-2 infection is mostly accompanied by mild COVID-19 symptoms. However, multisystem inflammatory syndrome (MIS-C) and long-term sequelae are often severe complications. Therefore, the protection of the pediatric population against SARS-CoV-2 with effective vaccines is particularly important. Here, we compare the humoral and cellular immune responses elicited in children (n = 15, aged 5–11 years) vaccinated with the RBD-based vaccines SOBERANA® 02 and SOBERANA® Plus combined in a heterologous scheme with those from children (n = 10, aged 4–11 years) who recovered from mild symptomatic COVID-19. (2) Methods: Blood samples were taken 14 days after the last dose for vaccinated children and 45–60 days after the infection diagnosis for COVID-19 recovered children. Anti-RBD IgG and ACE2-RBD inhibition were assessed by ELISA; IgA, cytokines, and cytotoxic-related proteins were determined by multiplex assays. Total B and T cell subpopulations and IFN-γ release were measured by multiparametric flow cytometry using a large panel of antibodies after in vitro stimulation with S1 peptides. (3) Results: Significant higher levels of specific anti-RBD IgG and IgA and ACE2-RBD inhibition capacity were found in vaccinated children in comparison to COVID-19 recovered children. Th1-like and Th2-like CD4+ T cells were also significantly higher in vaccinated subjects. IFN-γ secretion was higher in central memory CD4+ T cells of COVID-19 recovered children, but no differences between both groups were found in the CD4+ and CD8+ T cell effector, terminal effector, and naïve T cell subpopulations. In contrast to low levels of IL-4, high levels of IL-2, IL-6, IFN-γ, and IL-10 suggest a predominant Th1 cell polarization. Cytotoxic-related proteins granzyme A and B, perforin, and granulin were also found in the supernatant after S1 stimulation in both vaccinated and recovered children. (4) Conclusions: Vaccination with the heterologous scheme of SOBERANA® 02/SOBERANA® Plus induces a stronger antibody and cellular immune response compared to natural infections in young children. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Open-label phase I/II clinical trial of SARS-CoV-2 receptor binding domain-tetanus toxoid conjugate vaccine (FINLAY-FR-2) in combination with receptor binding domain-protein vaccine (FINLAY-FR-1A) in children

Author

Puga-Gómez, Rinaldo, primary, Ricardo-Delgado, Yariset, additional, Rojas-Iriarte, Chaumey, additional, Céspedes-Henriquez, Leyanis, additional, Piedra-Bello, Misleidys, additional, Vega-Mendoza, Dania, additional, Pérez, Noelvia Pestana, additional, Paredes-Moreno, Beatriz, additional, Rodríguez-González, Meiby, additional, Valenzuela-Silva, Carmen, additional, Sánchez-Ramírez, Belinda, additional, Rodríguez-Noda, Laura, additional, Pérez-Nicado, Rocmira, additional, González-Mugica, Raul, additional, Hernández-García, Tays, additional, Fundora-Barrios, Talía, additional, Echevarría, Martha Dubet, additional, Enriquez-Puertas, Juliet María, additional, Infante-Hernández, Yenicet, additional, Palenzuela-Díaz, Ariel, additional, Gato-Orozco, Evelyn, additional, Chappi-Estévez, Yanet, additional, Francisco-Pérez, Julio Cesar, additional, Suarez-Martinez, Miladi, additional, Castillo-Quintana, Ismavy C., additional, Fernandez-Castillo, Sonsire, additional, Climent-Ruiz, Yanet, additional, Santana-Mederos, Darielys, additional, García-Vega, Yanelda, additional, Toledo-Romani, María Eugenia, additional, Doroud, Delaram, additional, Biglari, Alireza, additional, Valdés-Balbín, Yury, additional, García-Rivera, Dagmar, additional, Vérez-Bencomo, Vicente, additional, Mesa-Herrera, María Elena, additional, García-Cristiá, Yarmila, additional, Verdecia-Sánchez, Leonor, additional, del Valle Rodríguez, Rafael, additional, Oquendo-de la Cruz, Yudalvies, additional, Álvarez-Montalvo, Daysi, additional, Grillo-Fortún, Randy, additional, López-González, Liset, additional, Galindo, Omaida Fonte, additional, Reyes-González, Yeseni, additional, González-Álvarez, Ana Beatriz, additional, Gorrita-Mora, Linet, additional, Valera-Fernández, Rodrigo, additional, Ontivero-Pino, Ivis, additional, Martínez-Pérez, Marisel, additional, Caballero-Gonzalez, Esperanza, additional, Garcés-Hechavarría, Aniurka, additional, Martínez-Bedoya, Dayle, additional, Medina-Nápoles, Maite, additional, Domínguez-Pentón, Yeney Regla, additional, Cazañas-Quintana, Yadira, additional, Barrios, Thais Fundora, additional, Fernández, Diana R. Hernández, additional, Bergado-Báez, Gretchen, additional, Orosa-Vazquez, Ivette, additional, Pi-Estopiñan, Franciscary, additional, Díaz-Hernández, Marianniz, additional, Cruz-Sui, Otto, additional, Noa-Romero, Enrique, additional, García-López, Arilia, additional, Muro, Sandra Rivadereira, additional, and Baro-Roman, Gerardo, additional

Published
2023
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