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1. The electronics of the High-Energy Particle Detector on board the CSES-01 satellite

Author

Ambrosi, G., Bartocci, S., Basara, L., Battiston, R., Burger, W.J., Campana, D., Caprai, M., Carfora, L., Castellini, G., Cipollone, P., Conti, L., Contin, A., De Donato, C., De Persio, F., De Santis, C., Follega, F.M., Guandalini, C., Gebbia, G., Ionica, M., Iuppa, R., Laurenti, G., Lazzizzera, I., Lolli, M., Manea, C., Martucci, M., Masciantonio, G., Mergé, M., Mese, M., Osteria, G., Pacini, L., Palma, F., Palmonari, F., Panico, B., Parmentier, A., Patrizii, L., Perfetto, F., Picozza, P., Pozzato, M., Puel, M., Rashevskaya, I., Ricci, E., Ricci, M., Ricciarini, S., Sahnoun, Z., Scotti, V., Sotgiu, A., Sparvoli, R., Vitale, V., Zoffoli, S., and Zuccon, P.

Published
2021
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2. Beam test calibrations of the HEPD detector on board the China Seismo-Electromagnetic Satellite

Author

Ambrosi, G., Bartocci, S., Basara, L., Battiston, R., Burger, W.J., Campana, D., Carfora, L., Castellini, G., Cipollone, P., Conti, L., Contin, A., De Donato, C., De Persio, F., De Santis, C., Follega, F.M., Guandalini, C., Ionica, M., Iuppa, R., Laurenti, G., Lazzizzera, I., Lolli, M., Manea, C., Martucci, M., Masciantonio, G., Mergé, M., Osteria, G., Pacini, L., Palma, F., Palmonari, F., Panico, B., Parmentier, A., Patrizii, L., Perfetto, F., Picozza, P., Piersanti, M., Pozzato, M., Puel, M., Rashevskaya, I., Ricci, E., Ricci, M., Ricciarini, S., Scotti, V., Sotgiu, A., Sparvoli, R., Spataro, B., Vitale, V., Zoffoli, S., and Zuccon, P.

Published
2020
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5. Cognitive complaint in early Parkinsonʼs disease: A pilot study

Author

Dupouy, J., Ory‐Magne, F., Mekies, C., Rousseau, V., Puel, M., Rerat, K., Pariente, J., Brefel‐Courbon, C., Andrieu, P, Angibaud, G, Aranda, A, Attané, F, Azais, C, Balague, J. P, Benazet, M, Beziaud, A.C, Boulesteix, M, Boulloche, N, Carel, C, Castan, D, Colombier, C, Cousin, F, Danielli, A, Dary Auriol, M, Dechaumont, S, Fanjaud, G, Fontayne‐Aguie, S, Lafontan, J. F, Gorce, P, Guiraud‐Chaumeil, C, Kurczewski, A, Martinez, P, Perez, F, Rouané, J. R, Rougier, M. H, Salandini, A. M, Sempe, A., Schmit, E., Stambouli, N., Tardy, J., Viala, F., and Vidry, E

Published
2018
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6. The electronics of the High-Energy Particle Detector on board the CSES-01 satellite

Author

Ambrosi, G, Bartocci, S, Basara, L, Battiston, R, Burger, Wj, Campana, D, Caprai, M, Carfora, L, Castellini, G, Cipollone, P, Conti, L, Contin, A, De Donato, C, De Persio, F, De Santis, C, Follega, Fm, Alini, C, Gebbia, G, Ionica, M, Iuppa, R, Laurenti, G, Lazzizzera, I, Lolli, M, Manea, C, Martucci, M, Masciantonio, G, Mergé, M, Mese, M, Osteria, G, Pacini, L, Palma, F, Palmonari, F, Panico, B, Parmentier, A, Patrizii, L, Perfetto, F, Picozza, P, Pozzato, M, Puel, M, Rashevskaya, I, Ricci, E, Ricci, M, Ricciarini, S, Sahnoun, Z, Scotti, V, Sotgiu, A, Sparvoli, R, Vitale, V, Zoffoli, S, Zuccon, P, Ambrosi G., Bartocci S., Basara L., Battiston R., Burger W.J., Campana D., Caprai M., Carfora L., Castellini G., Cipollone P., Conti L., Contin A., De Donato C., De Persio F., De Santis C., Follega F.M., Guandalini C., Gebbia G., Ionica M., Iuppa R., Laurenti G., Lazzizzera I., Lolli M., Manea C., Martucci M., Masciantonio G., Merge M., Mese M., Osteria G., Pacini L., Palma F., Palmonari F., Panico B., Parmentier A., Patrizii L., Perfetto F., Picozza P., Pozzato M., Puel M., Rashevskaya I., Ricci E., Ricci M., Ricciarini S., Sahnoun Z., Scotti V., Sotgiu A., Sparvoli R., Vitale V., Zoffoli S., Zuccon P., Ambrosi, G., Bartocci, S., Basara, L., Battiston, R., Burger, W. J., Campana, D., Caprai, M., Carfora, L., Castellini, G., Cipollone, P., Conti, L., Contin, A., De Donato, C., De Persio, F., De Santis, C., Follega, F. M., Guandalini, C., Gebbia, G., Ionica, M., Iuppa, R., Laurenti, G., Lazzizzera, I., Lolli, M., Manea, C., Martucci, M., Masciantonio, G., Merge, M., Mese, M., Osteria, G., Pacini, L., Palma, F., Palmonari, F., Panico, B., Parmentier, A., Patrizii, L., Perfetto, F., Picozza, P., Pozzato, M., Puel, M., Rashevskaya, I., Ricci, E., Ricci, M., Ricciarini, S., Sahnoun, Z., Scotti, V., Sotgiu, A., Sparvoli, R., Vitale, V., Zoffoli, S., and Zuccon, P.

Subjects
Physics, Settore FIS/01, Satellite experiment, Nuclear and High Energy Physics, Range (particle radiation), High energy particle, business.industry, Detector, Particle detector, Physics::Space Physics, Electronic, Detector techniques for Cosmology and Astroparticle Physic, Satellite, Electronics, Aerospace engineering, business, Instrumentation, Radiation hardening, Energy (signal processing)
Abstract

CSES (China Seismo-Electromagnetic Satellite) is a Chinese–Italian scientific space mission dedicated to monitor the variations of the main parameters of the topside ionosphere (electric and magnetic fields, plasma parameters, charge particle fluxes) caused by either natural emitters – especially earthquakes – or artificial ones. The CSES satellite was successfully launched from the Jiuquan Satellite Launch Center located in the west of Inner Mongolia on February 2nd, 2018, and it is now orbiting under nominal conditions. The expected mission lifetime amounts to 5 years. CSES is the first element of a multi-satellite monitoring system; several satellites are scheduled for the next few years. The High-Energy Particle Detector (HEPD) is the main contribution of the Italian collaboration to the mission. It was designed and built in order to detect electrons in the energy range between 3 and 100 MeV, protons between 30 and 200 MeV, and light nuclei in the MeV energy window. The electronics of the detector was designed following stringent requirements on mechanical and thermal stability, power consumption, radiation hardness and double redundancy. The system successfully went through the space qualification tests. In this paper, we describe the HEPD electronics, the space qualification tests performed before launch, and the in-flight performance of the detector.

Published
2021

7. Beam test calibrations of the HEPD detector on board the China Seismo-Electromagnetic Satellite

Author

Ambrosi, G, Bartocci, S, Basara, L, Battiston, R, Burger, W, Campana, D, Carfora, L, Castellini, G, Cipollone, P, Conti, L, Contin, A, De Donato, C, De Persio, F, De Santis, C, F M, Follega, Guandalini, C, Ionica, M, Iuppa, R, Laurenti, G, Lazzizzera, I, Lolli, M, Manea, C, Martucci, M, Masciantonio, G, Mergé, M, Osteria, G, Pacini, L, Palma, F, Palmonari, F, Panico, B, Parmentier, A, Patrizii, L, Perfetto, F, Picozza, P, Piersanti, M, Pozzato, M, Puel, M, Rashevskaya, I, Ricci, E, Ricci, M, Ricciarini, S, Scotti, V, Sotgiu, A, Sparvoli, R, Spataro, B, Vitale, V, Zoffoli, S, Zuccon, P, Ambrosi G., Bartocci S., Basara L., Battiston R., Burger W.J., Campana D., Carfora L., Castellini G., Cipollone P., Conti L., Contin A., De Donato C., De Persio F., De Santis C., Follega F.M., Guandalini C., Ionica M., Iuppa R., Laurenti G., Lazzizzera I., Lolli M., Manea C., Martucci M., Masciantonio G., Merge M., Osteria G., Pacini L., Palma F., Palmonari F., Panico B., Parmentier A., Patrizii L., Perfetto F., Picozza P., Piersanti M., Pozzato M., Puel M., Rashevskaya I., Ricci E., Ricci M., Ricciarini S., Scotti V., Sotgiu A., Sparvoli R., Spataro B., Vitale V., Zoffoli S., Zuccon P., Ambrosi, G., Bartocci, S., Basara, L., Battiston, R., Burger, W. J., Campana, D., Carfora, L., Castellini, G., Cipollone, P., Conti, L., Contin, A., De Donato, C., De Persio, F., De Santis, C., Follega, F. M., Guandalini, C., Ionica, M., Iuppa, R., Laurenti, G., Lazzizzera, I., Lolli, M., Manea, C., Martucci, M., Masciantonio, G., Merge, M., Osteria, G., Pacini, L., Palma, F., Palmonari, F., Panico, B., Parmentier, A., Patrizii, L., Perfetto, F., Picozza, P., Piersanti, M., Pozzato, M., Puel, M., Rashevskaya, I., Ricci, E., Ricci, M., Ricciarini, S., Scotti, V., Sotgiu, A., Sparvoli, R., Spataro, B., Vitale, V., Zoffoli, S., and Zuccon, P.

Subjects
Electromagnetic field, Nuclear and High Energy Physics, Cosmic ray, 02 engineering and technology, 01 natural sciences, Particle detector, 0103 physical sciences, Calibration, 010306 general physics, Instrumentation, Remote sensing, Physics, Settore FIS/01, Range (particle radiation), Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Data analysi, 021001 nanoscience & nanotechnology, INTERNATIONAL STATION, RADIATION BELTS, SCINTILLATION COUNTERS, Satellite, Physics::Space Physics, 0210 nano-technology, Beam (structure)
Abstract

CSES (China Seismo-Electromagnetic Satellite) is a Chinese-Italian space mission dedicated to monitoring of variations of the electromagnetic field and waves, plasma parameters, and particle fluxes induced by natural sources and artificial emitters in the near-Earth space. The satellite was launched from the Jiuquan Satellite Launch Center in the Gobi desert (Inner Mongolia, China) on 2, 2018. The expected mission lifetime amounts to 5 years. The Italian contribution to the mission includes the design and construction of the High-Energy Particle Detector (HEPD), aimed to detect electrons in the energy range between 3 and 100 MeV and protons between 30 and 200 MeV, as well as light nuclei in the MeV energy range. In this paper, we describe the calibration procedures applied to HEPD based on data acquired during two tests at accelerator laboratories, which were performed on HEPD Flight Model prior to the delivery to China for final integration. An additional acquisition of cosmic muons was performed in order to better characterize the detector response before launch.

Published
2020

9. Control and data acquisition software of the high-energy particle detector on board the China Seismo-Electromagnetic Satellite space mission

Author

Sotgiu, A, De Donato, C, Fornaro, C, Tassa, S, Scannavini, M, Iannaccio, D, Ambrosi, G, Bartocci, S, Basara, L, Battiston, R, Burger, Wj, Campana, D, Carfora, L, Castellini, G, Cipollone, P, Conti, L, Contin, A, De Persio, F, De Santis, C, Follega, Fm, Alini, C, Ionica, M, Iuppa, R, Laurenti, G, Lazzizzera, I, Lolli, M, Manea, C, Martucci, M, Masciantonio, G, Mergé, M, Osteria, G, Pacini, L, Palma, F, Palmonari, F, Panico, B, Parmentier, A, Perfetto, F, Picozza, P, Piersanti, M, Pozzato, M, Puel, M, Rashevskaya, I, Ricci, E, Ricci, M, Ricciarini, Sb, Scotti, V, Sparvoli, R, Spataro, B, Vitale, V, Zoffoli, S, Zuccon, P, Sotgiu, A., De Donato, C., Fornaro, C., Tassa, S., Scannavini, M., Iannaccio, D., Ambrosi, G., Bartocci, S., Basara, L., Battiston, R., Burger, W. J., Campana, D., Carfora, L., Castellini, G., Cipollone, P., Conti, L., Contin, A., De Persio, F., De Santis, C., Follega, F. M., Guandalini, C., Ionica, M., Iuppa, R., Laurenti, G., Lazzizzera, I., Lolli, M., Manea, C., Martucci, M., Masciantonio, G., Merge, M., Osteria, G., Pacini, L., Palma, F., Palmonari, F., Panico, B., Parmentier, A., Perfetto, F., Picozza, P., Piersanti, M., Pozzato, M., Puel, M., Rashevskaya, I., Ricci, E., Ricci, M., Ricciarini, S. B., Scotti, V., Sparvoli, R., Spataro, B., Vitale, V., Zoffoli, S., and Zuccon, P.

Subjects
Settore FIS/01, Digital signal processor, High energy particle, Computer science, data acquisition, Control (management), Detector, Real-time computing, embedded software, Space (mathematics), Embedded software, Data acquisition, earthquake, Satellite, Software, digital signal processor
Abstract

The China Seismo-Electromagnetic Satellite (CSES) space mission—also known as Limadou in Italian—is a scientific collaboration between China and Italy that aims to investigate the structure and dynamics of the iono/magnetosphere, and in particular to study the possible correlation of perturbations to the occurrence of high-magnitude seismic events. The Chinese satellite houses the Italian high-energy particle detector (HEPD), an apparatus composed of a silicon tracker and a calorimeter system, which detects electrons and protons in the energy ranges 3–100 and 30–200 MeV, respectively. The satellite was launched on February 2, 2018; after a commissioning phase dedicated to the setting of an optimal configuration, HEPD is fully operational since July 28, 2018. After a general overview of the CSES-Limadou mission, this article presents the structure of the HEPD apparatus and describes the design and implementation of the software for the embedded computer system that is responsible for HEPD management. The onboard software runs on the digital signal processors of two electronic boards (CPU and data acquisition), monitors system status, handles instrument data acquisition, performs periodic calibration of the subdetectors, performs data compression, and communicates with the satellite. An overview of HEPD in-flight operations and performance is given in the last section.

Published
2021

11. Predictors of cognitive decline and treatment response in a clinical trial on suspected prodromal Alzheimerʼs disease

Author

Teipel, Stefan J., Cavedo, Enrica, Grothe, Michel J., Lista, Simone, Galluzzi, Samantha, Colliot, Olivier, Chupin, Marie, Bakardjian, Hovagim, Dormont, Didier, Dubois, Bruno, Hampel, Harald, Godefroy, O., Deramond, H., Bouyx, Etcharry F., Papon, Pasco A., Dartigues, Jf., Allard, M., Rouaud, O., Ricolfi, F., Moreaud, O., Krainik, A., Pasquier, F., Bomboi, S., Delmaire, C., Couratier, P., Maubon, A., Vighetto, A., Croisile, B., Louis-Tisserand, G., Ceccaldi, M., Girard, N., Michel, B., Peretti, Mp., Touchon, J., Bonafe, A., Benetos, A., Barroche, G., Bracard, S., Vercelletto, M., Auffray, Calvier E., Robert, P., Chanalet, S., Dubois, B., Hampel, H., Dormont, D., Lehericy, S., Hugon, J., Pancrazi, M. P., Reizine, D., Gil, R., Vandermarcq, P., Novella, J. L., Pierot, L., Belliard, S., Carsin, M., Martinaud, O., Gerardin, E., Laurent, B., Barral, Fg., Sellal, F., Ousset, Pj., Puel, M., Ait Ameur, A., Dumas, H., Mondon, K., and Cottier, Jp.

Published
2016
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15. Control and Data Acquisition Software of the High-Energy Particle Detector on board the CSES Space Mission

Author

Sotgiu, A, De Donato, C, Fornaroy, C, Tassaz, S, Scannaviniz, M, Iannaccio, D, Ambrosi, G, Bartocci, S, Basara, L, Battiston, R, W J, Burger, Campana, D, Carfora, L, Castellini, G, Cipollone, P, Conti, L, Contin, A, De Persio, F, De Santis, C, F M, Follega, Guandalini, C, Ionica, M, Iuppa, R, Laurenti, G, Lazzizzera, I, Lolli, M, Manea, C, Martucci, M, Masciantonio, G, Mergé, M, Osteria, G, Pacin, L, Palma, F, Palmonari, F, Panico, B, Parmentier, A, Perfetto, F, Picozza, P, Piersanti, M, Pozzato, M, Puel, M, Rashevskaya, I, Ricci, E, Ricci, M, Ricciarini, S, Scotti, V, Sparvoli, R, Spataro, B, Vitale, V, Zoffoli, S, and Zuccon, P

Published
2021

27. Status and performance of the High Energy Particle Detector (HEPD) on-board the CSES-01 satellite

Author

Sotgiu, A, Ambrosi, G, Battiston, R, Bartocci, S, Basara, L, Burger, W, Campana, D, Carfora, L, Casolino, M, Castellini, G, Cipollone, P, Conti, L, Contin, A, De Donato, C, De Persio, F, De Santis, C, Di Ruzza, B, F M, Follega, Guandalini, C, Ionica, M, Iuppa, R, Laurenti, G, Lazzizzera, I, Lolli, M, Manea, C, Marcelli, L, Martucci, M, Masciantonio, G, Mergé, M, Osteria, G, Pacini, L, Palma, F, Palmonari, F, Panico, B, Parmentier, A, Patrizii, L, Perfetto, F, Picozza, P, Piersanti, M, Pozzato, M, Puel, M, Rashevskaya, I, Ricci, E, Ricci, M, Ricciarini, S, Scotti, V, Sparvoli, R, Spataro, B, Vitale, V, Zuccon, P, and Zoffoli, S

Published
2019

28. La redéfinition des normes de la tryptase dans la population pédiatrique révèle des différences selon le sexe : implications cliniques

Author

Puel, M., Rossignol, J., Diep, A., Nicaise Roland, P., Chollet Martin, S., Husson, J., Hermine, O., Bodemer, C., Brouzes, C., De Chaisemartin, L., and Polivka, L.

Abstract

La mesure de la tryptase basale sérique (sBT) est un outil diagnostique pour les pathologies impliquant l’activation des mastocytes. Elle est également utilisée pour diagnostiquer l’alpha-tryptasémie héréditaire (HαT), un trait génétique correspondant à une duplication/amplification de l’allèle alpha-1 du gène TPSAB1, entraînant une augmentation de la sBT. L’HαT concerne 5 % de la population générale, mais est plus fréquente chez les personnes ayant des pathologies mastocytaires clonales. Elle est également associée à un surrisque d’anaphylaxie au venin d’hyménoptères et idiopathique. Plusieurs études montrent la relation entre sBT et l’anaphylaxie chez les enfants ayant des allergies alimentaires. Basé sur des populations adultes, le seuil de sBT pour l’HαT a été fixé à 8ng/mL selon le 95epercentile. Notre étude visait à confirmer ce seuil dans la population pédiatrique.

Published
2024
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31. Space-Weather capabilities and preliminary results of the High Energy Particle Detector (HEPD) on-board the CSES-01 satellite

Author

Martucci, Matteo, primary, Ambrosi, G., additional, Battiston, R., additional, Bartocci, S., additional, Basara, L., additional, Burger, W.J, additional, Campana, D., additional, Carfora, L., additional, Casolino, M., additional, Castellini, G., additional, Cipollone, P., additional, Conti, L., additional, Contin, A., additional, De Donato, C, additional, De Persio, F, additional, De Santis, C, additional, Di Ruzza, B, additional, Follega, F.M, additional, Guandalini, C., additional, Ionica, M., additional, Iuppa, R., additional, Laurenti, G., additional, Lazzizzera, I., additional, Lolli, M., additional, Manea, C., additional, Marcelli, L., additional, Masciantonio, G., additional, Mergé, M., additional, Osteria, G., additional, Pacini, L., additional, Palma, F., additional, Palmonari, F., additional, Panico, B., additional, Parmentier, A., additional, Patrizii, L., additional, Perfetto, F., additional, Picozza, P., additional, Piersanti, M., additional, Pozzato, M., additional, Puel, M., additional, Rashevskaya, I., additional, Ricci, E., additional, Ricci, Marco, additional, Ricciarini, S., additional, Scotti, V., additional, Sotgiu, A., additional, Sparvoli, R., additional, Spataro, B., additional, Vitale, V., additional, Zuccon, P., additional, and Zoffoli, S., additional

Published
2019
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32. Status and performance of the High Energy Particle Detector (HEPD) on-board the CSES-01 satellite

Author

Sotgiu, Alessandro, primary, Ambrosi, G., additional, Battiston, R., additional, Bartoccia, S., additional, Basara, L., additional, Burger, W. J, additional, Campana, D., additional, Carfora, L., additional, Casolino, M., additional, Castellini, G., additional, Cipollone, P., additional, Conti, L., additional, Contin, A., additional, De Donato, C, additional, De Persio, F, additional, De Santis, C, additional, Di Ruzza, B, additional, Follega, F. M, additional, Guandalini, C., additional, Ionica, M., additional, Iuppa, R., additional, Laurenti, G., additional, Lazzizzera, I., additional, Lolli, M., additional, Manea, C., additional, Marcelli, L., additional, Martucci, M., additional, Masciantonio, G., additional, Mergé, M., additional, Osteria, G., additional, Pacini, L., additional, Palma, F., additional, Palmonari, F., additional, Panico, B., additional, Parmentier, A., additional, Patrizii, L., additional, Perfetto, F., additional, Picozza, P., additional, Piersanti, M., additional, Pozzato, M., additional, Puel, M., additional, Rashevskaya, I., additional, Ricci, E., additional, Ricci, Marco, additional, Ricciarini, S., additional, Scotti, V., additional, Sparvoli, R., additional, Spataro, B., additional, Vitale, V., additional, Zuccon, P., additional, and Zoffoli, S., additional

Published
2019
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34. Scientific Goals and In-orbit Performance of the High-energy Particle Detector on Board the CSES

Author

Picozza, P., primary, Battiston, R., additional, Ambrosi, G., additional, Bartocci, S., additional, Basara, L., additional, Burger, W. J., additional, Campana, D., additional, Carfora, L., additional, Casolino, M., additional, Castellini, G., additional, Cipollone, P., additional, Conti, L., additional, Contin, A., additional, De Donato, C., additional, De Santis, C., additional, Follega, F. M., additional, Guandalini, C., additional, Ionica, M., additional, Iuppa, R., additional, Laurenti, G., additional, Lazzizzera, I., additional, Lolli, M., additional, Manea, C., additional, Marcelli, L., additional, Martucci, M., additional, Masciantonio, G., additional, Mergé, M., additional, Osteria, G., additional, Pacini, L., additional, Palma, F., additional, Palmonari, F., additional, Panico, B., additional, Parmentier, A., additional, Patrizii, L., additional, Perfetto, F., additional, Piersanti, M., additional, Pozzato, M., additional, Puel, M., additional, Rashevskaya, I., additional, Ricci, E., additional, Ricci, M., additional, Ricciarini, S., additional, Scotti, V., additional, Sotgiu, A., additional, Sparvoli, R., additional, Spataro, B., additional, Vitale, V., additional, Zuccon, P., additional, and Zoffoli, S., additional

Published
2019
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42. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Author

Majounie, E1, Renton, Ae, Mok, K, Dopper, Eg, Waite, A, Rollinson, S, Chiò, A, Restagno, G, Nicolaou, N, Simon-Sanchez, J, van Swieten JC, Abramzon, Y, Johnson, Jo, Sendtner, M, Pamphlett, R, Orrell, Rw, Mead, S, Sidle, Kc, Houlden, H, Rohrer, Jd, Morrison, Ke, Pall, H, Talbot, K, Ansorge, O, Hernandez, Dg, Arepalli, S, Sabatelli, M, Mora, G, Corbo, M, Giannini, F, Calvo, A, Englund, E, Borghero, G, Floris, Gl, Remes, Am, Laaksovirta, H, Mccluskey, L, Trojanowski, Jq, Van Deerlin VM, Schellenberg, Gd, Nalls, Ma, Drory, Ve, Lu, Cs, Yeh, Th, Ishiura, H, Takahashi, Y, Tsuji, S, Le Ber, I, Brice, A, Drepper, C, Williams, N, Kirby, J, Shaw, P, Hardy, J, Tienari, Pj, Heutink, P, Morris, Hr, Pickering-Brown, S, Traynor, Bj, Adamson, G, Bayer, Aj, Beck, J, Callister, Jb, Blake, Dj, Blumen, Sc, Collinge, J, Dunckley, T, Ealing, J, East, S, Elman, L, Gerhard, A, Guerreiro, Rj, Gwinn, K, Halliwell, N, Hamdalla, Hh, Hewitt, C, Ince, P, Jablonka, S, James, C, Kent, L, Knock, Jc, Lynch, T, Mahoney, C, Mann, D, Neal, J, Norris, D, O'Dowd, S, Richardson, A, Rossor, M, Rothstein, J, Scholz, Sw, Snowden, J, Stephan, Da, Toulson, G, Turner, Mr, Warren, Jd, Young, K, Weng, Yh, Kuo, Hc, Lai, Sc, Huang, Cl, Camuzat, A, Entraingues, L, Guillot-Noël, Verpillat, P, Blanc, F, Camu, W, Clerget-Darpoux, F, Corcia, P, Couratier, P, Didic, M, Dubois, B, Duyckaerts, C, Guedj, E, Golfier, V, Habert, Mo, Hannequin, D, Lacomblez, L, Meininger, V, Salachas, F, Levy, R, Michel, Bf, Pasquier, F, Puel, M, Thomas-Anterion, C, Sellal, F, Vercelletto, M, Moglia, C, Cammarosano, S, Canosa, A, Gallo, S, Brunetti, M, Ossola, I, Marinou, K, Papetti, L, Pisano, F, Pinter, Gl, Conte, A, Luigetti, M, Zollino, M, Lattante, S, Marangi, G, la Bella, V, Spataro, R, Colletti, T, Battistini, S, Ricci, C, Caponnetto, C, Mancardi, G, Mandich, P, Salvi, F, Bartolomei, I, Mandrioli, J, Sola, P, Lunetta, C, Penco, S, Monsurrò, Mr, Tedeschi, G, Conforti, Fl, Gambardella, A, Quattrone, A, Volanti, P, Floris, G, Cannas, A, Piras, V, Marrosu, F, Marrosu, Mg, Murru, Mr, Pugliatti, M, Parish, Ld, Sotgiu, A, Solinas, G, Ulgheri, L, Ticca, A, Simone, I, Logroscino, G., Neurology, Erasmus MC other, The Chromosome 9-ALS/FTD Consortium, Human genetics, NCA - Neurodegeneration, Università degli studi di Torino (UNITO), Department of Clinical Genetics, Institute for Clinical Neurobiology, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), MRC Prion Unit, UCL Institute of neurology, UCL Institute of Neurology, UCL Institute of Neurology, Queen Square, London, Department of Neuroscience, Catholic University, Roma, Fondazione Maugeri, Department of Neuroscience, University of Siena, Siena, Department of Neurology, Chang Gung Memorial Hospital [Taipei] (CGMH), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, MRC Centre for Neuropsychiatric Genetics and Genomics, Medical Research Council (MRC)-School of Medicine [Cardiff], Cardiff University-Institute of Medical Genetics [Cardiff]-Cardiff University-Institute of Medical Genetics [Cardiff], Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Università degli studi di Torino = University of Turin (UNITO), Julius-Maximilians-Universität Würzburg (JMU), UCL Institute of Neurology, Queen Square [London], Università degli Studi di Siena = University of Siena (UNISI), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
MESH: Signal Transduction, Male, MESH: Vesicular Transport Proteins, MESH: Membrane Glycoproteins, MESH: DNA Repeat Expansion, MESH: Genotype, Cohort Studies, MESH: Protein Structure, Tertiary, MESH: Aged, 80 and over, MESH: Interferon Regulatory Factor-3, 0302 clinical medicine, C9orf72, MESH: Child, MESH: RNA, Small Interfering, 80 and over, genetics, Age of Onset, Child, MESH: Cohort Studies, MESH: Amyotrophic Lateral Sclerosis, MESH: Aged, Genetics, Aged, 80 and over, 0303 health sciences, MESH: Middle Aged, DNA Repeat Expansion, MESH: Toll-Like Receptor 4, Middle Aged, Penetrance, 3. Good health, Settore MED/26 - NEUROLOGIA, Neurology, MESH: Young Adult, MESH: HEK293 Cells, Child, Preschool, Frontotemporal Dementia, Female, Sample collection, Chromosomes, Human, Pair 9, MESH: Myeloid Differentiation Factor 88, Frontotemporal dementia, Human, Pair 9, Adult, MESH: Protein Transport, medicine.medical_specialty, Adolescent, Genotype, MESH: Age of Onset, MESH: RNA Interference, Clinical Neurology, MESH: Frontotemporal Dementia, MESH: Genetic Loci, TARDBP, Chromosomes, 03 medical and health sciences, Open Reading Frames, Young Adult, MESH: Cross-Sectional Studies, Internal medicine, medicine, MESH: Chemokine CCL5, Humans, ddc:610, Preschool, MESH: Adaptor Proteins, Signal Transducing, 030304 developmental biology, Aged, MESH: Adolescent, MESH: Humans, business.industry, MESH: Transfection, MESH: Child, Preschool, Haplotype, Amyotrophic Lateral Sclerosis, MESH: Adult, MESH: Adaptor Proteins, Vesicular Transport, MESH: Open Reading Frames, medicine.disease, MESH: Male, MESH: Cell Line, C9orf72 Protein, Cross-Sectional Studies, MESH: Endosomes, Genetic Loci, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), MESH: Lipopolysaccharides, MESH: Chromosomes, Human, Pair 9, business, Trinucleotide repeat expansion, MESH: Female, Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, genetics, Child, Child, Preschool, Chromosomes, genetics, Cohort Studies, Cross-Sectional Studies, DNA Repeat Expansion, genetics, Female, Frontotemporal Dementia, genetics, Genetic Loci, Genotype, Humans, Male, Middle Aged, Open Reading Frames, genetics, Young Adult, 030217 neurology & neurosurgery
Abstract

International audience; BACKGROUND: We aimed to accurately estimate the frequency of a hexanucleotide repeat expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). METHODS: We screened 4448 patients diagnosed with ALS (El Escorial criteria) and 1425 patients with FTD (Lund-Manchester criteria) from 17 regions worldwide for the GGGGCC hexanucleotide expansion using a repeat-primed PCR assay. We assessed familial disease status on the basis of self-reported family history of similar neurodegenerative diseases at the time of sample collection. We compared haplotype data for 262 patients carrying the expansion with the known Finnish founder risk haplotype across the chromosomal locus. We calculated age-related penetrance using the Kaplan-Meier method with data for 603 individuals with the expansion. FINDINGS: In patients with sporadic ALS, we identified the repeat expansion in 236 (7*0%) of 3377 white individuals from the USA, Europe, and Australia, two (4*1%) of 49 black individuals from the USA, and six (8*3%) of 72 Hispanic individuals from the USA. The mutation was present in 217 (39*3%) of 552 white individuals with familial ALS from Europe and the USA. 59 (6*0%) of 981 white Europeans with sporadic FTD had the mutation, as did 99 (24*8%) of 400 white Europeans with familial FTD. Data for other ethnic groups were sparse, but we identified one Asian patient with familial ALS (from 20 assessed) and two with familial FTD (from three assessed) who carried the mutation. The mutation was not carried by the three Native Americans or 360 patients from Asia or the Pacific Islands with sporadic ALS who were tested, or by 41 Asian patients with sporadic FTD. All patients with the repeat expansion had (partly or fully) the founder haplotype, suggesting a one-off expansion occurring about 1500 years ago. The pathogenic expansion was non-penetrant in individuals younger than 35 years, 50% penetrant by 58 years, and almost fully penetrant by 80 years. INTERPRETATION: A common Mendelian genetic lesion in C9orf72 is implicated in many cases of sporadic and familial ALS and FTD. Testing for this pathogenic expansion should be considered in the management and genetic counselling of patients with these fatal neurodegenerative diseases. FUNDING: Full funding sources listed at end of paper (see Acknowledgments).

Published
2012
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43. FG-Cloud : Cloud communautaire distribué à vocation scientifique

Author

Pansanel, J., Airaj, M., Biscarat, C., Clementin, N., Gondrand, C., Geiger, S., Hamar, V., Jouvin, M., Legoll, V., Li, S., Loomis, C., Marquillie, M., Jean-Marc PIERSON, Puel, M., Romier, G., Thiebolt, F., Tsaregorodtsev, A., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), and Vernay, Emmanuelle

Subjects
[INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

44. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Author

Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chiò A, Restagno G, Nicolaou N, Simon Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O, Chromosome 9 ALS/FTD Consortium, French research network on FTLD/FTLD/ALS, ITALSGEN Consortium, Adamson G, Bayer AJ, Beck J, Callister JB, Blake DJ, Blumen SC, Collinge J, Dunckley T, Ealing J, East S, Elman L, Gerhard A, Guerreiro RJ, Gwinn K, Halliwell N, Hamdalla HH, Hewitt C, Ince P, Jablonka S, James C, Kent L, Knock JC, Lynch T, Mahoney C, Mann D, Neal J, Norris D, O'Dowd S, Richardson A, Rossor M, Rothstein J, Scholz SW, Snowden J, Stephan DA, Toulson G, Turner MR, Warren JD, Young K, Weng YH, Kuo HC, Lai SC, Huang CL, Camuzat A, Entraingues L, Guillot Noël, Verpillat P, Blanc F, Camu W, Clerget Darpoux F, Corcia P, Couratier P, Didic M, Dubois B, Duyckaerts C, Guedj E, Golfier V, Habert MO, Hannequin D, Lacomblez L, Meininger V, Salachas F, Levy R, Michel BF, Pasquier F, Puel M, Thomas Anterion C, Sellal F, Vercelletto M, Moglia C, Cammarosano S, Canosa A, Gallo S, Brunetti M, Ossola I, Marinou K, Papetti L, Pisano F, Pinter GL, Conte A, Luigetti M, Zollino M, Lattante S, Marangi G, la Bella V, Spataro R, Colletti T, Battistini S, Ricci C, Caponnetto C, Mancardi G, Mandich P, Salvi F, Bartolomei I, Mandrioli J, Sola P, Lunetta C, Penco S, Conforti FL, Gambardella A, Quattrone A, Volanti P, Floris G, Cannas A, Piras V, Marrosu F, Marrosu MG, Murru MR, Pugliatti M, Parish LD, Sotgiu A, Solinas G, Ulgheri L, Ticca A, Simone I, Logroscino G, Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F, Calvo A, Englund E, Borghero G, Floris GL, Remes AM, Laaksovirta H, McCluskey L, Trojanowski JQ, Van Deerlin VM, Schellenberg GD, Nalls MA, Drory VE, Lu CS, Yeh TH, Ishiura H, Takahashi Y, Tsuji S, Le Ber I, Brice A, Drepper C, Williams N, Kirby J, Shaw P, Hardy J, Tienari PJ, Heutink P, Morris HR, Pickering Brown S, Traynor BJ, MONSURRO', Maria Rosaria, TEDESCHI, Gioacchino, Majounie, E, Renton, Ae, Mok, K, Dopper, Eg, Waite, A, Rollinson, S, Chiò, A, Restagno, G, Nicolaou, N, Simon Sanchez, J, van Swieten, Jc, Abramzon, Y, Johnson, Jo, Sendtner, M, Pamphlett, R, Orrell, Rw, Mead, S, Sidle, Kc, Houlden, H, Rohrer, Jd, Morrison, Ke, Pall, H, Talbot, K, Ansorge, O, Chromosome, 9 ALS/FTD Consortium, French research network on, Ftld/ftld/al, Italsgen, Consortium, Adamson, G, Bayer, Aj, Beck, J, Callister, Jb, Blake, Dj, Blumen, Sc, Collinge, J, Dunckley, T, Ealing, J, East, S, Elman, L, Gerhard, A, Guerreiro, Rj, Gwinn, K, Halliwell, N, Hamdalla, Hh, Hewitt, C, Ince, P, Jablonka, S, James, C, Kent, L, Knock, Jc, Lynch, T, Mahoney, C, Mann, D, Neal, J, Norris, D, O'Dowd, S, Richardson, A, Rossor, M, Rothstein, J, Scholz, Sw, Snowden, J, Stephan, Da, Toulson, G, Turner, Mr, Warren, Jd, Young, K, Weng, Yh, Kuo, Hc, Lai, Sc, Huang, Cl, Camuzat, A, Entraingues, L, Guillot, Noël, Verpillat, P, Blanc, F, Camu, W, Clerget Darpoux, F, Corcia, P, Couratier, P, Didic, M, Dubois, B, Duyckaerts, C, Guedj, E, Golfier, V, Habert, Mo, Hannequin, D, Lacomblez, L, Meininger, V, Salachas, F, Levy, R, Michel, Bf, Pasquier, F, Puel, M, Thomas Anterion, C, Sellal, F, Vercelletto, M, Moglia, C, Cammarosano, S, Canosa, A, Gallo, S, Brunetti, M, Ossola, I, Marinou, K, Papetti, L, Pisano, F, Pinter, Gl, Conte, A, Luigetti, M, Zollino, M, Lattante, S, Marangi, G, la Bella, V, Spataro, R, Colletti, T, Battistini, S, Ricci, C, Caponnetto, C, Mancardi, G, Mandich, P, Salvi, F, Bartolomei, I, Mandrioli, J, Sola, P, Lunetta, C, Penco, S, Monsurro', Maria Rosaria, Tedeschi, Gioacchino, Conforti, Fl, Gambardella, A, Quattrone, A, Volanti, P, Floris, G, Cannas, A, Piras, V, Marrosu, F, Marrosu, Mg, Murru, Mr, Pugliatti, M, Parish, Ld, Sotgiu, A, Solinas, G, Ulgheri, L, Ticca, A, Simone, I, Logroscino, G, Hernandez, Dg, Arepalli, S, Sabatelli, M, Mora, G, Corbo, M, Giannini, F, Calvo, A, Englund, E, Borghero, G, Floris, Gl, Remes, Am, Laaksovirta, H, Mccluskey, L, Trojanowski, Jq, Van Deerlin, Vm, Schellenberg, Gd, Nalls, Ma, Drory, Ve, Lu, C, Yeh, Th, Ishiura, H, Takahashi, Y, Tsuji, S, Le Ber, I, Brice, A, Drepper, C, Williams, N, Kirby, J, Shaw, P, Hardy, J, Tienari, Pj, Heutink, P, Morris, Hr, Pickering Brown, S, and Traynor, Bj

Published
2012

45. French Intensive Care Society, International congress - Réanimation 2016

Author

Jaillette, E, Girault, C, Brunin, G, Zerimech, F, Chiche, A, Broucqsault Dedrie, C, Fayolle, C, Minacori, F, Alves, I, Barrailler, S, Robriquet, L, Delaporte, E, Thellier, D, Delcourte, C, Duhamel, A, Nseir, S, Valette, X, Desmeulles, I, Savary, B, Masson, R, Seguin, A, Daubin, C, Sauneuf, B, Verrier, P, Pottier, V, Orabona, M, Samba, D, Viquesnel, G, Lermuzeaux, M, Hazera, P, Hanouz, J, Parienti, J, Du Cheyron, D, Demoule, A, Clavel, M, Rolland Debord, C, Perbet, S, Terzi, N, Kouatchet, A, Wallet, F, Roze, H, Vargas, F, Guérin, C, Dellamonica, J, Jaber, S, Similowski, T, Quenot, J, Binquet, C, Vinsonneau, C, Barbar, S, Vinault, S, Deckert, V, Lemaire, S, Hssain, A, Bruyère, R, Souweine, B, Lagrost, L, Adrie, C, Jung, B, Daurat, A, De Jong, A, Chanques, G, Mahul, M, Monnin, M, Molinari, N, Lheureux, O, Trepo, E, Hites, M, Cotton, F, Wolff, F, Surin, R, Créteur, J, Vincent, J, Gustot, T, Jacobs, F, Taccone, F, Neuville, M, Timsit, J, El Helali, N, Le Monnier, A, Magalhaes, E, Radjou, A, Smonig, R, Soubirou, J, Voiriot, G, Sonneville, R, Bouadma, L, Mourvillier, B, Gélisse, E, Brasseur, A, Roisin, S, De Backer, D, Van Ruychevelt, V, Carlier, E, Piagnerelli, M, Vanhaeverbeek, M, Danguy, C, Biston, P, Au, S, Begot, E, Dalmay, F, Repessé, X, Prat, G, Bouferrache, K, Slama, M, Vieillard Baron, A, Monnet, X, Marik, P, Teboul, J, Jozwiak, M, Richard, C, Chauvet, J, El Dash, S, Delastre, O, Bouffandeau, B, Jusserand, D, Michot, J, Bauer, F, Brazier, F, Mercado, P, Kontar, L, Titeca, D, De Cagny, B, Bacari Risal, G, Riviere, A, Maizel, J, Guillot, C, Le Reun, C, Lampin, M, Sadik, A, Botte, A, Leteurtre, S, Collins, A, Kempeneers, C, Cajgfinger, N, Ohlmann, C, Pouyau, R, Subtil, F, Baudin, F, Massenavette, B, Javouhey, E, Milesi, C, Essouri, S, Liet, J, Afanetti, M, Durand, S, Durand, P, Roze, J, Dupont, D, Cambonie, G, Soyer, B, Rusca, M, Lukaszewicz, A, Crassard, I, Guichard, J, Bresson, D, de la Garanderie, D, Cantier, M, Sabben, C, Louedec, L, Delbosc, S, Journé, C, Ou, P, Klein, I, Chau, F, Lefort, A, Desilles, J, Michel, J, Mazighi, M, Salem, O, Demeret, S, Bolgert, F, Sharshar, T, Grabli, D, Arib, S, Crippa, I, Soummer, A, Engrand, N, Guedin, P, Aldea, S, Cerf, C, Desailly, V, Pasquier, P, Brun, P, Roux, D, Latournerie, G, Kasprzyk, L, Grosjean, V, Latreche, A, Habert, P, Huot, S, Jobin, T, Tesnière, A, Dreyfuss, D, Ricard, J, Mignon, A, Gaudry, S, Laithier, F, Kimmoun, A, Chouihed, T, Albizzati, S, Camenzind, E, Vanhuyse, F, Levy, B, Cour, M, Venet, F, Hernu, R, Demaret, J, Monneret, G, Argaud, L, Dumas, F, Lamhaut, L, Rosencher, J, Pène, F, Varenne, O, Carli, P, Jouven, X, Spaulding, C, Cariou, A, Geri, G, Bonnetain, F, Marijon, E, Empana, J, Mirouse, A, Resche Rigon, M, Mayaux, J, Rabbat, A, Meert, A, Benoit, D, Bruneel, F, Azoulay, E, Dupuis, C, Schwebel, C, Ruckly, S, Goldgran Toledano, D, Marcotte, G, Lafarge, A, Pichereau, C, Theodose, I, Scotto, M, Kemlin, D, Ghrenassia, E, Schlemmer, B, Vimpere, D, Galicier, L, Contou, D, Guérot, E, Grimaldi, D, Ricome, S, Maury, E, Plantefève, G, Dessap, A, Brun Buisson, C, de Prost, N, Dubé, B, Delemazure, J, Dres, M, Rousseau, L, Drouot, X, Diaz, V, Rebollar, Y, Frat, J, Thille, A, Aissa, D, Coquet, P, Ruiz, J, Ferre, F, Hoarau, L, Riu Poulenc, B, Bataille, B, Silva, S, Baudel, J, Bigé, N, Tahiri, J, Dubée, V, Guidet, B, Ait Oufella, H, Jinglun, L, Shen, F, Bailly, S, Leroy, O, Montravers, P, Constantin, J, Dupont, H, Guillemot, D, Lortholary, O, Perrigault, P, Gangneux, J, Razazi, K, Mekontso Dessap, A, Jansen, C, Lecronier, M, Sandrine, V, Mira, J, Blein, S, Marin, N, Rousseau, C, Charpentier, J, Pachot, A, Hraiech, S, Bordes, J, De, L, Mège, J, Forel, J, Guervilly, C, Adda, M, Raoult, D, Papazian, L, Kentish Barnes, N, Cohen Solal, Z, Souppart, V, Kerhuel, L, Haubertin, C, Exbrayat, I, Rozières, E, Argain, A, Suc, A, Vignes, M, Cougot, P, Fourcade, O, Brunel, E, Messika, J, Tubach, F, Dubief, E, Pasquet, B, Guillo, S, Pierron, C, Grimaud, M, Farnoux, C, Maillard, A, Decavèle, M, 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P, Boles, J, Herbrecht, J, Kaeuffer, C, Meyer, A, Arfi, K, Lesage, F, Séguret, S, Dupic, L, De Saint Blanquat, L, Baptiste, A, Georges, H, Delannoy, P, Devos, P, Albarracin, D, Ducousso Lacaze, A, Dufour, J, Cabasson, S, Veinstein, A, Chatellier, D, Robert, R, Ha, V, Lau, N, Mimoun, L, Forceville, X, Maamar, A, Chevalier, S, Botoc, V, Rouleau, S, Desachy, A, Calvat, S, Lafon, C, Cracco, C, Temime, J, Molmy, P, Gasan, G, Béranger, A, Chappuy, H, Bertrand, P, Beurton, A, Bodet Contentin, L, Danin, P, Dubois, E, Karaca, Y, Mora, P, Vodovar, D, Desbrosses, Y, Chauchet, A, Daguindau, E, Deconinck, E, Chermak, A, Baron, M, Calvet, L, Sapin, A, Pereira, B, Vettoretti, L, Lacroix, J, Clayton, L, Sabri, E, Bardiaux, L, Tiberghien, P, Hebert, P, Lengliné, E, Socié, G, Borcoman, E, Rusinova, K, Del Galy, A, Mercier, M, Hamel, J, Raveau, T, Moles, M, Clavert, A, Hunault Berger, M, Ifrah, N, Schmidt Tanguy, A, Carreira, S, Lavault, S, Pallanca, O, Morawiec, E, Arnulf, I, D'Humières, T, Carrié, C, 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Persichini, R, Hullin, T, Deye, N, Aubertein, P, Paul, M, Bougouin, W, Sandroni, C, Passouant, O, Llitjos, J, Chenevier Gobeaux, C, Batteux, F, Drouet, L, Voicu, S, Henry, P, Dillinger, J, Resiere, D, Dessoy, A, Faivre, V, Damoisel, C, Stiel, L, Galoisy, A, Mauvieux, L, Zobairi, F, Angles Cano, E, Piau, C, Jeannet, R, Feuillard, J, Jolly, L, Boufenzer, A, Carrasco, K, Derive, M, Merdji, H, Belaidouni, N, Toubiana, J, L'Hermitte, Y, Woimant, F, Oppenheim, C, Couvreur, C, Dolveck, F, Devriese, M, Dupeyrat, S, Ray, P, Lefevre, G, Fartoukh, M, Roothaer, N, Carpentier, A, Vaniet, F, Maisonneuve, A, Wiel, E, Canu, S, Hammad, E, Antonini, F, Poirier, M, Vigne, C, Haddam, M, Alingrin, J, Dangers, L, Mangiapan, G, Huet, I, Dhalluin, X, Bautin, N, Quiot, J, De Vecchi, C, Chenivesse, C, Smaoui, M, El Alami, E, Weiss, N, Mochel, F, Galanaud, D, Puybasset, L, Lodey, M, Guiller, E, Vuillaume, C, De Pasquale, F, Demonet, J, Sinnah, F, Dalloz, M, D'Ortho, M, Rouvel Tallec, A, Couret, D, Catan, A, Nativel, B, Planesse, C, Diotel, N, Meilhac, O, Roy Gash, F, Lebard, C, Larbi, A, Gaudin, V, Bonnin, F, Sultan, O, Hoc, C, Mathieu, E, Lapergue, B, Bourdain, F, Caron, M, Parrot, A, Labbe, V, Hafiani, E, Quesnel, C, Genay, S, Décaudin, B, Ethgen, S, Odou, P, Lebuffe, G, Mcquilte, Z, Allaouchiche, B, Verdière, B, Nyunga, M, Banaias, N, Colling, D, Kauv, M, Blondeau, E, Auclin, E, Haw Berlemont, C, Taieb, J, Oudard, S, Morissette, G, Kechaou, W, Litalien, C, Merouani, A, Phan, V, Bouchard, J, Starck, J, Briand, N, Sachs, P, Angoulvant, F, Sommet, J, Holvoet, L, Benkerrou, M, Dreyfus, L, Bordet, F, Touzet, S, Denis, A, Le Coz, J, Chéron, G, Nabbout, R, Patteau, G, Heilbronner, C, Hubert, P, Oualha, M, Crulli, B, Toledano, B, Poirier, N, Vobecky, S, Khouadja, H, Vinet, M, Vinclair, C, Beloncle, F, Radermacher, P, Asfar, P, Coupez, E, Bohé, J, Shinotsuka, C, Caironi, P, Villois, P, Fontana, V, Creteur, J, Pourcine, F, Vong, L, Weyer, C, Akando, B, Abdallah, R, Wetzstein, M, Antier, N, Serroukh, Y, Boudjeltia, K, Joosten, A, Rousseau, A, Delabranche, X, Grunebaum, L, Mootien, Y, Gaci, R, Garric, J, Delbove, A, Darreau, C, Dargent, A, Soudry Faure, A, De Chambrun, M, Demondion, P, Blanchard, J, Chocron, S, Meneveau, N, Corsi, F, Meynieu, P, Repusseau, B, Germain, A, Baudry, G, Hierle, L, Besch, G, Thomas, G, Cassir, N, Dizier, S, Roch, A, Trebbia, G, Govindaradjou, K, Devaquet, J, Picard, C, Parquin, F, Leguen, M, Felten, M, Sage, E, Chapelier, A, Duruisseaux, M, Fleury, J, Antoine, M, Carette, M, Wislez, M, Givel, C, De Margerie Mellon, C, De Kerviler, E, Tandjaoui Lambiotte, Y, Freynet, O, Baux, E, Das, V, Talec, P, Anguel, N, Louis, G, Girerd, N, Tallon, P, Hadchouel Duvergé, A, Salvi, N, Cairet, P, Delacourt, C, Blandine, B, Beraud, L, Lamaziere, A, Lionnet, F, Lehingue, S, D'Journo, X, Jean Marie, F, Thibault, R, Makhlouf, A, Mulliez, A, Dadet, S, Kekstas, G, Preiser, J, Rotovnik, K, Rozalen, I, Kupczyk, K, Krznaric, Z, Cano, N, Pichard, C, Le Roux, B, Jotterand, 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Elkhawand, C, Vermeesh, F, Vermeesh, F., and CITERIO, GIUSEPPE

Abstract

Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study

Published
2016

47. La mémoire autobiographique épisodique antérograde est atteinte à très court délai (20 minutes) dans la maladie d'Alzheimer précoce

Author

Barbeau, E., Lemesle, B., Saint-Aubert, Laure, Calvet, Benjamin, Puel, M., Chollet, François, Pariente, J., Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Neurologie vasculaire, pathologie neuro-dégénérative et explorations fonctionnelles du système nerveux [Toulouse], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Psychiatrie [CHU Limoges], CHU Limoges, Centre de Mémoire de Ressources et de Recherches [Limoges] (CMRR Limoges), CHU Limoges-CH Esquirol [Limoges] (CH Esquirol), and Grelier, Elisabeth

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

48. Alzheimer patients engage an alternative cortical network during a memory task

Author

PARIENTE J, COLE S, HENSON R, CLARE L, KENNEDY A, ROSSOR M, CIPOLOTTI, Lisa, PUEL M, DEMONET JF, CHOLLET F, FRACKOWIAK R., PARIENTE J, COLE S, HENSON R, CLARE L, KENNEDY A, ROSSOR M, CIPOLOTTI L, PUEL M, DEMONET JF, CHOLLET F, and FRACKOWIAK R

Subjects
Settore M-PSI/02 - Psicobiologia E Psicologia Fisiologica, Alzheimer, (AD)
Abstract

We conducted an event-related functional magnetic resonance imaging experiment to better understand the potentially compensatory alternative brain networks activated by a clinically relevant face-name association task in Alzheimer’s disease (AD) patients and matched control subjects. We recruited 17 healthy subjects and 12 AD patients at an early stage of the disease. They underwent functional magnetic resonance imaging scanning in four sessions. Each of the sessions combined a “study” phase and a “test” phase. Face/name pairs were presented in each study phase, and subjects were asked to associate faces with names. In the test phase, a recognition task, faces seen in the study phase were presented each with four different names. The task required selection of appropriate previously associated names from the study phase. Responses were recorded for post hoc classification into those successfully or unsuccessfully encoded. There were significant differences between the groups in accuracy and reaction time. Comparison of correctly versus incorrectly encoded and recognized pairs in the two groups indicated bilateral hippocampal hypoactivation both when encoding and recognizing in the AD group. Moreover, patients showed bilateral hyperactivation of parts of the parietal and frontal lobes. We discuss whether hyperactivation of a frontoparietal network reflects compensatory strategies for failing associative memory in AD patients.

Published
2005

49. Epi'Toul : Une épreuve neuropsychologique de mémoire épisodique écologique pour la détection de la maladie d'Alzheimer pré-démentielle

Author

Calvet, Benjamin, Mirabel, H, Saint-Aubert, Laure, Barbeau, E., Vaissiere, G., Planton, M., Puel, M., Chollet, François, Démonet, Jean-François, Pariente, J., Grelier, Elisabeth, Centre de Mémoire de Ressources et de Recherches [Limoges] (CMRR Limoges), CHU Limoges-CH Esquirol [Limoges] (CH Esquirol), Service de Psychiatrie [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Imagerie cérébrale et handicaps neurologiques (ICHN), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurologie vasculaire, pathologie neuro-dégénérative et explorations fonctionnelles du système nerveux [Toulouse], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], and CHU Toulouse [Toulouse]

Subjects
[SDV] Life Sciences [q-bio], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV]Life Sciences [q-bio], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

50. [Early diagnosis of Alzheimer's disease]

Author

Saint-Aubert, Laure, Puel, M., Chollet, François, Pariente, J., Imagerie cérébrale et handicaps neurologiques (ICHN), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurologie vasculaire, pathologie neuro-dégénérative et explorations fonctionnelles du système nerveux [Toulouse], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Centre de recherche cerveau et cognition (CERCO), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Diagnostic Imaging, Biomarqueurs, Neuropsychological Tests, PET scan, Amyloïde, Radiography, Early Diagnosis, Alzheimer Disease, Disease Progression, Alzheimer, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Radionuclide Imaging, IRM
Abstract

International audience; INTRODUCTION: Diagnosis of Alzheimer's disease (AD) remains difficult to establish, and can only be considered as certain thanks to anatomopathological evidence, or genetic mutations. Current diagnostic criteria rely on innovative imaging and biological tools, in order to detect pathological cues from very early stages, and with best sensibility and sensitivity. STATE OF ART: Advances in neuro-imaging enabled the development of different tools to help establishing the diagnosis, such as cerebral atrophy assessment on magnetic resonance imaging (MRI), and cerebral metabolism study on positron emission tomography (PET). Besides, the increasing use of in vivo biological markers, combined to clinical criteria, enables to discriminate patients from healthy controls at even earlier stages. This includes studies on tau and beta-amyloid proteins concentrations in the cerebrosinal fluid, and amyloid-specific radioligands uptake. Familial forms of Alzheimer represent a great model for studying early or even pre-symptomatic AD, as genetic analyses constitute a diagnosis of certainty, even though they usually evolve earlier and faster. PERSPECTIVES, CONCLUSION: Diagnostic tools are more and more numerous and performant. According to patients' clinical heterogeneity, it appears essential to associate different method to investigate, in order to make a diagnosis as early and as reliable as possible.

Published
2012

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