Search

Your search keyword '"Puci, Mariangela V."' showing total 27 results
Start Over Author "Puci, Mariangela V."
27 results on '"Puci, Mariangela V."'

6. Vitamin D Status in an Italian Pediatric Cohort: Is There a Role for Tobacco Smoking Exposure?

Author

Clemente, Maria Grazia, Argiolas, Dario, Bassu, Stefania, Bitti, Angela, Locci, Cristian, Argiolas, Mauro, Argiolas, Lino, Saderi, Laura, Puci, Mariangela V., Sotgiu, Giovanni, Blue, Mary E., and Antonucci, Roberto

Subjects
VITAMIN D deficiency, RISK assessment, DESCRIPTIVE statistics, LUMINESCENCE spectroscopy, ENVIRONMENTAL exposure, IMMUNOASSAY, VITAMIN D, PASSIVE smoking, DISEASE risk factors, CHILDREN
Abstract

Objective: Vitamin D deficiency is a common public health issue worldwide. The purpose of this study was to investigate the vitamin D status and its potential determinants in children residing in Sardinia (40°N), Italy. Methods: Children were enrolled over a 12-month period. Serum 25(OH)D was measured by an immunochemiluminescence assay. A questionnaire was used to gather information on other variables, including passive smoke exposure. Results: A total of 182 children (males: 51.7%; median age: 9 years) were included. Mean±standard deviation serum 25(OH)D was 25.2±8.3 ng/mL for the whole group. The majority (n=123, 67.6%) had vitamin D sufficient values >20 ng/mL, while 32.4% (n=59) had vitamin D insufficient/deficient values (≤20 ng/mL). Among the variables investigated, passive smoke exposure was significantly associated with insufficient 25(OH)D levels (p<0.0001). Conclusion: Our results confirm that hypovitaminosis D is common in Italian children. Furthermore, passive smoke exposure was identified as a significant risk factor for hypovitaminosis D. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Electrocardiography in Children Hospitalized for COVID-19 and Not Suffering from Multisystem Inflammatory Syndrome in Children (MIS-C): An Observational Study

Author

Locci, Cristian, primary, Bassareo, Pier Paolo, additional, Fanelli, Chiara, additional, Maida, Ivana, additional, Saderi, Laura, additional, Puci, Mariangela V., additional, Sotgiu, Giovanni, additional, Culeddu, Maria Chiara, additional, Piga, Stefania, additional, Oppo, Antonella, additional, and Antonucci, Roberto, additional

Published
2024
Full Text
View/download PDF

12. Preliminary Results of Feasibility and Acceptability of Self-Collection for Cervical Screening in Italian Women

Author

Sechi, Illari, primary, Muresu, Narcisa, additional, Puci, Mariangela V., additional, Saderi, Laura, additional, Del Rio, Arcadia, additional, Cossu, Andrea, additional, Muroni, Maria R., additional, Castriciano, Santina, additional, Martinelli, Marianna, additional, Cocuzza, Clementina E., additional, Sotgiu, Giovanni, additional, and Piana, Andrea, additional

Published
2023
Full Text
View/download PDF

13. Preliminary Results of Feasibility and Acceptability of Self-Collection for Cervical Screening in Italian Women

Author

Sechi, I, Muresu, N, Puci, M, Saderi, L, Del Rio, A, Cossu, A, Muroni, M, Castriciano, S, Martinelli, M, Cocuzza, C, Sotgiu, G, Piana, A, Sechi, Illari, Muresu, Narcisa, Puci, Mariangela V., Saderi, Laura, Del Rio, Arcadia, Cossu, Andrea, Muroni, Maria R., Castriciano, Santina, Martinelli, Marianna, Cocuzza, Clementina E., Sotgiu, Giovanni, Piana, Andrea, Sechi, I, Muresu, N, Puci, M, Saderi, L, Del Rio, A, Cossu, A, Muroni, M, Castriciano, S, Martinelli, M, Cocuzza, C, Sotgiu, G, Piana, A, Sechi, Illari, Muresu, Narcisa, Puci, Mariangela V., Saderi, Laura, Del Rio, Arcadia, Cossu, Andrea, Muroni, Maria R., Castriciano, Santina, Martinelli, Marianna, Cocuzza, Clementina E., Sotgiu, Giovanni, and Piana, Andrea

Abstract

Background: Given the diagnostic accuracy of HPV-DNA tests in terms of self-collected samples, in order to implement self-sampling in cervical screening programs, the standardization of the pre-analytical phase, including decisions concerning the choice of medium, the volume of elution, and storage conditions, are necessary, in addition to understanding the potential factors involved in acceptability by women. On this basis, we carried out a cross-sectional study to assess (i) the stability of dry vaginal self-collected samples stored at room temperature for up to 4 weeks after elution in 2 mL of eNat® (Copan) medium, and (ii) the acceptability of self-collection in enrolled women. Methods: 185 women were enrolled in the LILT (Italian League Against Tumors) regional project. A self-sampling kit, including a dry FLOQSwab® (Copan), instructions for use, and a satisfaction questionnaire, were supplied for each woman and sent by mail to the laboratory. The HPV-DNA test was carried out using the AnyplexTM II HPV HR (Seegene) kit. To evaluate the specimen’s stability, 185 dry vaginal swabs were eluted in eNat®, a lyses-based molecular medium and tested for HPV detection at two different time points (<6 days and 1 month after elution). The Cohen’s Kappa coefficients and McNemar test were used to assess the agreement of HPV-DNA at different times. Results: We found high agreement in terms of HPV-DNA results among the samples tested at two different time points (Cohen K = 0.98; p < 0.0001). Moreover, most of the women found it easy to use self-collection devices and the pictorial instructions clear to understand. Approximately half of the enrolled women declared preferring self-sampling to clinician-collected methods. Conclusion: Our results display the high reliability and accuracy of HPV-DNA tests using dry vaginal self-collection FLOQSwabs® devices eluted in 2 mL of molecular medium. The analysis of the questionnaire showed a high acceptability of self-collection am

Published
2023

14. Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry

Author

Martelli, Eugenio, primary, Zamboni, Matilde, additional, Sotgiu, Giovanni, additional, Saderi, Laura, additional, Federici, Massimo, additional, Sangiorgi, Giuseppe M., additional, Puci, Mariangela V., additional, Martelli, Allegra R., additional, Messina, Teresa, additional, Frigatti, Paolo, additional, Borrelli, Maria Pia, additional, Ruotolo, Carlo, additional, Ficarelli, Ilaria, additional, Rubino, Paolo, additional, Pezzo, Francesco, additional, Carbonari, Luciano, additional, Angelini, Andrea, additional, Galeazzi, Edoardo, additional, Di Pinto, Luca Calia, additional, Fiore, Franco M., additional, Palmieri, Armando, additional, Ventoruzzo, Giorgio, additional, Mazzitelli, Giulia, additional, Ragni, Franco, additional, Bozzani, Antonio, additional, Forliti, Enzo, additional, Castagno, Claudio, additional, Volpe, Pietro, additional, Massara, Mafalda, additional, Moniaci, Diego, additional, Pagliasso, Elisa, additional, Peretti, Tania, additional, Ferrari, Mauro, additional, Troisi, Nicola, additional, Modugno, Piero, additional, Maiorano, Maurizio, additional, Bracale, Umberto M., additional, Panagrosso, Marco, additional, Monaco, Mario, additional, Giordano, Giovanni, additional, Natalicchio, Giuseppe, additional, Biello, Antonella, additional, Celoria, Giovanni M., additional, Amico, Alessio, additional, Di Bartolo, Mauro, additional, Martelli, Massimiliano, additional, Munaó, Roberta, additional, Razzano, Davide, additional, Colacchio, Giovanni, additional, Bussetti, Francesco, additional, Lanza, Gaetano, additional, Cardini, Antonio, additional, Di Benedetto, Bartolomeo, additional, De Laurentis, Mario, additional, Taurino, Maurizio, additional, Sirignano, Pasqualino, additional, Cappiello, Pierluigi, additional, Esposito, Andrea, additional, Trimarchi, Santi, additional, Romagnoli, Silvia, additional, Padricelli, Andrea, additional, Giudice, Giorgio, additional, Crinisio, Adolfo, additional, Di Nardo, Giovanni, additional, Battaglia, Giuseppe, additional, Tringale, Rosario, additional, De Vivo, Salvatore, additional, Compagna, Rita, additional, Tolva, Valerio S., additional, D’Alessio, Ilenia, additional, Curci, Ruggiero, additional, Giovannetti, Simona, additional, D’Arrigo, Giuseppe, additional, Basile, Giusi, additional, Frigerio, Dalmazio, additional, Veraldi, Gian Franco, additional, Mezzetto, Luca, additional, Ippoliti, Arnaldo, additional, Oddi, Fabio M., additional, and Settembrini, Alberto M., additional

Published
2023
Full Text
View/download PDF

16. Prediction of bowel management independence after ischemic spinal cord injury

Author

Pavese, Chiara, Scivoletto, Giorgio, Puci, Mariangela V, Abel, Rainer F, Curt, Armin, Maier, Doris, Rupp, Rüdiger, Schubert, Martin, Weidner, Norbert, Montomoli, Cristina, Kessler, Thomas M, and University of Zurich

Subjects
ROC Curve, Rehabilitation, Humans, Physical Therapy, Sports Therapy and Rehabilitation, 610 Medicine & health, 10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center, Recovery of Function, Prognosis, Spinal Cord Injuries
Abstract

Ischemic spinal cord injury (SCI) belongs to the heterogeneous group of non-traumatic SCI, while the course of sensorimotor and functional recovery is comparable to traumatic SCI. Recently, we derived from data of patients with traumatic SCI a valid model to predict an independent and reliable bowel management one year after SCI.To evaluate the performance of this model to predict an independent and reliable bowel management one year following ischemic SCI.Prognostic study - observational study.European Multicenter Study about Spinal Cord Injury (EMSCI) ClinicalTrials.gov: NCT01571531.One hundred and forty-two patients with ischemic SCI of various level and severity of injury.The prediction model relied on a single predictor collected within 40 days from injury, the International Standards for Neurological Classification of Spinal Cord Injury total motor score. Bowel outcome one year after SCI derived from the dichotomization of the Spinal Cord Independence Measure (SCIM) item 7 scores. We defined a positive outcome as independent bowel management with regular movements and appropriate timing with no or rare accidents (score of 10 in SCIM version II and score of 8 or 10 in version III).The model showed a fair discrimination with an area under the receiver operating characteristic (ROC) curve of 0.780 (95% confidence interval=0.702-0.860). In addition, the model displayed an acceptable accuracy and calibration.The study extends the validity of our rule to patients with ischemic SCI, thus providing the first model to predict an independent and reliable bowel management in this population.The model may be employed in clinical practice to counsel patients, to define the rehabilitation aims and to estimate the need of assistance after discharge, as well as in the research field for the optimization of patients' allocation in the design of future clinical trials.

Published
2022

17. Prediction of bowel management independence after ischemic spinal cord injury

Author

Pavese, Chiara; https://orcid.org/0000-0002-2061-0346, Scivoletto, Giorgio; https://orcid.org/0000-0001-5766-6952, Puci, Mariangela V; https://orcid.org/0000-0001-5656-6845, Abel, Rainer F; https://orcid.org/0000-0002-8328-8438, Curt, Armin, Maier, Doris, Rupp, Rüdiger; https://orcid.org/0000-0002-3873-1023, Schubert, Martin; https://orcid.org/0000-0003-4495-6533, Weidner, Norbert; https://orcid.org/0000-0002-1447-8967, Montomoli, Cristina, Kessler, Thomas M; https://orcid.org/0000-0002-1991-5919, Pavese, Chiara; https://orcid.org/0000-0002-2061-0346, Scivoletto, Giorgio; https://orcid.org/0000-0001-5766-6952, Puci, Mariangela V; https://orcid.org/0000-0001-5656-6845, Abel, Rainer F; https://orcid.org/0000-0002-8328-8438, Curt, Armin, Maier, Doris, Rupp, Rüdiger; https://orcid.org/0000-0002-3873-1023, Schubert, Martin; https://orcid.org/0000-0003-4495-6533, Weidner, Norbert; https://orcid.org/0000-0002-1447-8967, Montomoli, Cristina, and Kessler, Thomas M; https://orcid.org/0000-0002-1991-5919

Abstract

BACKGROUND: Ischemic spinal cord injury (SCI) belongs to the heterogeneous group of non-traumatic SCI, while the course of sensorimotor and functional recovery is comparable to traumatic SCI. Recently, we derived from data of patients with traumatic SCI a valid model to predict an independent and reliable bowel management one year after SCI. AIM: To evaluate the performance of this model to predict an independent and reliable bowel management one year following ischemic SCI. DESIGN: Prognostic study - observational study. SETTING: European Multicenter Study about Spinal Cord Injury (EMSCI) ClinicalTrials.gov: NCT01571531. POPULATION: One hundred and forty-two patients with ischemic SCI of various level and severity of injury. METHODS: The prediction model relied on a single predictor collected within 40 days from injury, the International Standards for Neurological Classification of Spinal Cord Injury total motor score. Bowel outcome one year after SCI derived from the dichotomization of the Spinal Cord Independence Measure (SCIM) item 7 scores. We defined a positive outcome as independent bowel management with regular movements and appropriate timing with no or rare accidents (score of 10 in SCIM version II and score of 8 or 10 in version III). RESULTS: The model showed a fair discrimination with an area under the receiver operating characteristic (ROC) curve of 0.780 (95% confidence interval=0.702-0.860). In addition, the model displayed an acceptable accuracy and calibration. CONCLUSIONS: The study extends the validity of our rule to patients with ischemic SCI, thus providing the first model to predict an independent and reliable bowel management in this population. CLINICAL REHABILITATION IMPACT: The model may be employed in clinical practice to counsel patients, to define the rehabilitation aims and to estimate the need of assistance after discharge, as well as in the research field for the optimization of patients' allocation in the design of future clinical t

Published
2022

18. The Role of Crowd Support on Home Advantage during COVID-19 Restrictions on Italian Football Competitions. Comparison between 2018–19 and 2020–21 Seasons of the Italian Serie A and Serie B Championships

Author

Vandoni, Matteo, primary, Ferraro, Ottavia E., additional, Gatti, Alessandro, additional, Marin, Luca, additional, Giuriato, Matteo, additional, Silvestri, Dario, additional, Lovecchio, Nicola, additional, Puci, Mariangela V., additional, and Carnevale Pellino, Vittoria, additional

Published
2022
Full Text
View/download PDF

19. External Validation Confirms Validity of a Simple Model to Predict Bowel Outcome After Traumatic Spinal Cord Injury

Author

Pavese, Chiara, Scivoletto, Giorgio, Puci, Mariangela V, Schubert, Martin, Curt, Armin, Finazzi Agrò, Enrico, Montomoli, Cristina, Kessler, Thomas M, University of Zurich, and Kessler, Thomas M

Subjects
2742 Rehabilitation, 2728 Neurology (clinical), 2808 Neurology, 610 Medicine & health, 10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center
Published
2021

24. Patient Perception of Musculoskeletal MR: A Survey Research

Author

Belloni, Elena, Tentoni, Stefania, Puci, Mariangela V., Bortolotto, Chandra, Bottinelli, Olivia, Cellina, Michaela, Gibelli, Daniele, Rosti, Cristina, Oliva, Giancarlo, Montomoli, Cristina, Preda, Lorenzo, Calliada, Fabrizio, and Scagnelli, Paola

Abstract

Background: When undergoing magnetic resonance (MR) exams, patients need to lie still in a noisy and enclosed environment for a long time. This condition, together with the anxiety burden related to the possible implications of the scan results, can entail a diagnostic outcome of poor quality. Objective: The aim of the study was to evaluate the personal perception and experience of adult patients undergoing unenhanced musculoskeletal MR. Methods: Consecutive outpatients undergoing unenhanced MR of spine, knee or shoulder were asked to respond to a 10-item questionnaire at the end of the exam. Results: 263 patients (54% males, mean age 50.6 ±15.8 years, range 18-83 years) completed the questionnaire. Patients declared that the most disturbing elements of the exam were forced immobility and noise (30% in both cases). Females perceived significantly higher degree of anxiety than males (56% vs. 21%, p<0.001). Exam duration was correctly perceived by 83% of the population. Patients' satisfaction was generally high (mean above 9 over 10). Conclusion: Explanations and clarifications given before the exam were considered satisfactory by the patients. Despite some negative aspects such as noise, immobility and anxiety especially in females, patients' satisfaction with our service was high, as well as the willingness to return.

Published
2020
Full Text
View/download PDF

25. Cardiorespiratory fitness assessment using the PREFIT test in Italian children: a preliminary dataset.

Author

VALARANI, Francesca, GIURIATO, Matteo, PUCI, Mariangela V., VANDONI, Matteo, CODELLA, Roberto, and LOVECCHIO, Nicola

Subjects
CARDIOPULMONARY fitness, PERFORMANCE standards, CARDIOVASCULAR system, PHYSICAL fitness, RESPIRATORY organs, CARDIOPULMONARY system
Abstract

BACKGROUND: The cardiorespiratory fitness (CRF) is one of the most important indicators of the health-related physical fitness components because it reflects the efficiency of the cardiovascular and respiratory systems. To indirectly assess CRF, the original protocol of the 20mSRT was adapted in a new version suitable for children called 20mSRT-PREFIT, providing performances comparable to the standards o f the European area. In fact, CRF normative values are missing in the Italian context and therefore they would be meaningful to be assessed. We aimed to determine CRF from 20mSRT-PREFIT in a small sample of Italian pre-school children and to compare the outcomes with the available European references. METHODS: A convenience sample of 5-year-old pre-school children (N.=32, M/F ratio: 19/13) was freely recruited from a kindergarten of the northwest Italy. Children performed the 20mSRT-PREFIT and the number of full shuttles, exhaustion time, and maximum speed were collected to obtain CRF. RESULTS: Predicted VO2max was similar between Italian male and female groups. All other outcomes originating from the 20mSRT-PREFIT were consistent with those included in the available European databases. CONCLUSIONS: According to these preliminary indications, Italian pre-school children may have a CRF level equivalent to that one ascertained in other European countries. Thus, current rakings should be cautiously scrutinized, as they might inappropriately underrate Italian children’s performances. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

26. Impact of COVID-19 on Patients with Beta-Thalassemia <italic>Major</italic>: An Observational Study.

Author

Vacca, Nadia, Locci, Cristian, Serra, Fabiola, Chicconi, Elena, Puci, Mariangela V., Sotgiu, Giovanni, Amadu, Antonio Matteo, and Antonucci, Roberto

Abstract

Introduction: The prevalence of COVID-19 is slightly lower, and its mortality is higher in beta-thalassemia patients than in the general population. We evaluated the impact of COVID-19 in terms of incidence, clinical course, management, and specific antibody response to vaccination, in a cohort of patients with beta-thalassemia major. Methods: We retrospectively enrolled all transfusion-dependent beta-thalassemia major patients attending the Thalassemia Day Care Center of the University Hospital of Sassari, Italy, from March 1, 2020, to May 31, 2021. For each patient, demographic, clinical, laboratory, instrumental, and therapy data were collected. Patients aged ≥16 years received two doses of mRNA COVID-19 vaccine. Anti-SARS-CoV-2 serum antibodies were tested before and after the first vaccine dose. Results: A total of 68 patients (median age: 36.5 years; IQR: 13–42 years) were included. Nasopharyngeal swab (NPS) for SARS-CoV-2 detection by RT-PCR was positive in 5 (7.35%) of 68 patients (4 symptomatic). No COVID-19-related complications, hospitalizations, or deaths were observed. The transfusion regimen and iron chelation therapy were not significantly changed. Prior to COVID-19 vaccination, anti-SARS-CoV-2 antibodies were tested in 61 patients, 51 negative and 10 positive; five of the latter were also positive for SARS-CoV-2 on NPS. The 46 vaccinated subjects had an antibody response, with higher levels in subjects previously infected with SARS-CoV-2. Conclusion: Our findings suggest that patients with beta-thalassemia major are not at a higher risk of contracting SARS-CoV-2 infection and developing a severe form of COVID-19 despite being considered more vulnerable than the general population. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

27. Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry

Author

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe M. Sangiorgi, Mariangela V. Puci, Allegra R. Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco M. Fiore, Armando Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Piero Modugno, Maurizio Maiorano, Umberto M. Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni M. Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio S. Tolva, Ilenia D’Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D’Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio M. Oddi, Alberto M. Settembrini, Martelli, Eugenio, Zamboni, Matilde, Sotgiu, Giovanni, Saderi, Laura, Federici, Massimo, Sangiorgi, Giuseppe M., Puci, Mariangela V., Martelli, Allegra R., Messina, Teresa, Frigatti, Paolo, Borrelli, Maria Pia, Ruotolo, Carlo, Ficarelli, Ilaria, Rubino, Paolo, Pezzo, Francesco, Carbonari, Luciano, Angelini, Andrea, Galeazzi, Edoardo, Di Pinto, Luca Calia Di, Fiore, Franco M., Palmieri, Armando, Ventoruzzo, Giorgio, Mazzitelli, Giulia, Ragni, Franco, Bozzani, Antonio, Forliti, Enzo, Castagno, Claudio, Volpe, Pietro, Massara, Mafalda, Moniaci, Diego, Pagliasso, Elisa, Peretti, Tania, Ferrari, Mauro, Troisi, Nicola, Modugno, Piero, Maiorano, Maurizio, Bracale, Umberto M., Panagrosso, Marco, Monaco, Mario, Giordano, Giovanni, Natalicchio, Giuseppe, Biello, Antonella, Celoria, Giovanni M., Amico, Alessio, Di Bartolo, Mauro, Martelli, Massimiliano, Munaó, Roberta, Razzano, Davide, Colacchio, Giovanni, Bussetti, Francesco, Lanza, Gaetano, Cardini, Antonio, Di Benedetto, Bartolomeo, De Laurentis, Mario, Taurino, Maurizio, Sirignano, Pasqualino, Cappiello, Pierluigi, Esposito, Andrea, Trimarchi, Santi, Romagnoli, Silvia, Padricelli, Andrea, Giudice, Giorgio, Crinisio, Adolfo, Di Nardo, Giovanni, Battaglia, Giuseppe, Tringale, Rosario, De Vivo, Salvatore, Compagna, Rita, Tolva, Valerio S., D’Alessio, Ilenia, Curci, Ruggiero, Giovannetti, Simona, D’Arrigo, Giuseppe, Basile, Giusi, Frigerio, Dalmazio, Veraldi, Gian Franco, Mezzetto, Luca, Ippoliti, Arnaldo, Oddi, Fabio M., and Settembrini, Alberto M.

Subjects
chronic limb-threatening ischemia, age, limb salvage, outcome, sex, Medicine (miscellaneous), Settore MED/09
Abstract

Background: Identifying sex-related differences/variables associated with 30 day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI). Methods: Multicenter/retrospective/observational study. A database was sent to all the Italian vascular surgeries to collect all the patients operated on for CLTI in 2019. Acute lower-limb ischemia and neuropathic-diabetic foot are not included. Follow-up: One year. Data on demographics/comorbidities, treatments/outcomes, and 30 day/1 year mortality were investigated. Results: Information on 2399 cases (69.8% men) from 36/143 (25.2%) centers. Median (IQR) age: 73 (66–80) and 79 (71–85) years for men/women, respectively (p < 0.0001). Women were more likely to be over 75 (63.2% vs. 40.1%, p = 0.0001). More men smokers (73.7% vs. 42.2%, p < 0.0001), are on hemodialysis (10.1% vs. 6.7%, p = 0.006), affected by diabetes (61.9% vs. 52.8%, p < 0.0001), dyslipidemia (69.3% vs. 61.3%, p < 0.0001), hypertension (91.8% vs. 88.5%, p = 0.011), coronaropathy (43.9% vs. 29.4%, p < 0.0001), bronchopneumopathy (37.1% vs. 25.6%, p < 0.0001), underwent more open/hybrid surgeries (37.9% vs. 28.8%, p < 0.0001), and minor amputations (22% vs. 13.7%, p < 0.0001). More women underwent endovascular revascularizations (61.6% vs. 55.2%, p = 0.004), major amputations (9.6% vs. 6.9%, p = 0.024), and obtained limb-salvage if with limited gangrene (50.8% vs. 44.9%, p = 0.017). Age > 75 (HR = 3.63, p = 0.003) is associated with 30 day mortality. Age > 75 (HR = 2.14, p < 0.0001), nephropathy (HR = 1.54, p < 0.0001), coronaropathy (HR = 1.26, p = 0.036), and infection/necrosis of the foot (dry, HR = 1.42, p = 0.040; wet, HR = 2.04, p < 0.0001) are associated with 1 year mortality. No sex-linked difference in mortality statistics. Conclusion: Women exhibit fewer comorbidities but are struck by CLTI when over 75, a factor associated with short- and mid-term mortality, explaining why mortality does not statistically differ between the sexes.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results