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146 results on '"Puccetti, F."'

2. Early regression index (ERI) on MR images as response predictor in esophageal cancer treated with neoadjuvant chemo-radiotherapy: Interim analysis of the prospective ESCAPE trial

Author

Fiorino, C., Palumbo, D., Mori, M., Palazzo, G., Pellegrini, A.E., Albarello, L., Belardo, A., Canevari, C., Cossu, A., Damascelli, A., Elmore, U., Mazza, E., Pavarini, M., Passoni, P., Puccetti, F., Slim, N., Steidler, S., Del Vecchio, A., Di Muzio, N.G., Chiti, A., Rosati, R., and De Cobelli, F.

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2024
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3. Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer: results of a multicentre national study

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Rottoli, M, Spinelli, A, Pellino, G, Gori, A, Calini, G, Flacco, M, Manzoli, L, Poggioli, G, Romano, A, Belvedere, A, Lanci, A, Parlanti, D, Vago, G, Pezzuto, A, Canavese, A, Dajti, G, Cardelli, S, Catalioto, C, Russo, I, Violante, T, Morezzi, D, Maurino, L, Filippone, E, Cuicchi, D, Bernante, P, Jovine, E, Lombardi, R, Masetti, M, Cipressi, C, Offi, M, Larotonda, C, Puglisi, S, Barbosa, A, Vaiana, R, Bianchi, P, Tonti, C, Codignola, C, Zorcolo, L, Restivo, A, Deidda, S, Marchetti, M, Ippolito, L, Spolverato, G, Pucciarelli, S, Marchegiani, F, Ghio, G, Zagolin, G, Glavas, D, Tomassi, M, Rosati, R, Elmore, U, Gozzini, L, Calef, R, Puccetti, F, Cossu, A, Vignali, A, Morino, M, Allaix, M, Cannata, G, Lombardi, E, Ammirati, C, Piceni, C, Buccianti, P, Balestri, R, Puccini, M, Pezzati, D, D'Ischia, R, Asta, V, Sargenti, B, Taddei, G, Bonari, F, Boni, G, Ferrero, A, Mineccia, M, Gonella, F, Palisi, M, Danese, F, Cherubini, V, Perotti, S, Carvello, M, Carbone, F, Luberto, A, Calafiore, E, De Lucia, F, Sacchi, M, Sasia, D, Giuffrida, M, Ballauri, E, Cardile, M, Armentano, S, Beltrami, E, Preve, G, Vercellone, B, Mozzon, M, Folliero, C, Lirusso, C, Vecchiato, M, Ziccarelli, A, Gattesco, D, Moretti, L, Crestale, S, Banchini, F, Capelli, P, Romboli, A, Palmieri, G, Conti, L, Rizzi, N, Bonfili, D, De Manzini, N, Germani, P, Osenda, E, Cortinovis, S, Giunta, C, Fracon, S, Abdallah, H, Bogoni, S, Portolani, N, Nascimbeni, R, Molfino, S, Tiberio, G, Garosio, I, Lamperti, G, Rigosa, D, Ercolani, G, Solaini, L, Cavaliere, D, Avanzolini, A, D'Acapito, F, Chiarella, L, Di Pietrantonio, D, Annunziata, D, Piccolo, R, Sorrentino, M, Pansini, M, Cojutti, A, Graziano, M, Callegari, F, Balzarotti, L, Dameno, V, Cattaneo, A, Santolamazza, G, Altieri, C, Magarini, R, Pietrabissa, A, Dominioni, T, Pugliese, L, Peri, A, Botti, M, Salvetti, F, Boni, L, Cassinotti, E, Baldari, L, Messina, V, D'Abrosca, V, Cianci, P, Tumolo, R, Gattulli, D, Restini, E, Minafra, M, Sederino, M, Bottalico, B, Pilati, P, Franzato, B, Mattara, G, De Simoni, O, Barina, A, Tonello, M, Muratore, A, Calabro, M, Federico Pipitone, N, Cuzzola, B, Van Nood, E, Passuello, N, Frasson, A, Mammano, E, Faccio, L, Vittadello, F, Bressan, A, Sarzo, G, Tamini, N, Oldani, M, Cigagna, L, Carissimi, F, De Carlo, G, Baccalini, E, Nespoli, L, Giordano, A, Cantafio, S, Grifoni, L, Matani, D, Livi, S, Delogu, D, Scognamillo, F, Marrosu, A, Guerrini, L, Ugolini, G, Ghignone, F, Frascaroli, G, Albertini, N, Zattoni, D, Taffurelli, G, Montroni, I, Colombo, F, Danelli, P, Bondurri, A, Maffioli, A, Bonomi, A, Pezzoli, I, Cammarata, F, Goletti, O, Molteni, M, Assisi, A, Quartierini, G, Da Lio, C, Verdi, D, Mondi, I, Peluso, C, Macchi, L, Tanzanu, M, Zanzi, F, Pellegrini, S, Andreuccetti, J, D'Alessio, R, Pignata, G, De Capua, M, Canfora, I, Ottaviani, L, Lepiane, P, Balla, A, De Carlo, A, Saraceno, F, Scaramuzzo, R, Guida, A, Aguzzi, D, Bellora, P, Gentilli, S, Monni, M, Nikaj, H, Cillara, N, Cannavera, A, Deserra, A, Margiani, C, Cabula, R, Dettori, M, Gramignano, G, Lezoche, G, Ortenzi, M, Orlandoni, E, Curzi, F, Vitali, F, Capomagi, P, Palmieri, M, Del Rio, P, Bonati, E, Loderer, T, Cozzani, F, Rossini, M, Agnesi, S, Capolupo, G, Caricato, M, Carannante, F, Masciana, G, Marrelli, M, Miacci, V, Lauricella, S, Tonini, V, Cervellera, M, Pisconti, S, Lozito, C, Shahu, J, Mongelli, C, Morelli, G, Sartarelli, L, Sica, G, Siragusa, L, Bagaglini, G, Franceschilli, M, Bellato, V, Fiorani, C, Taddei, A, Risaliti, M, Bartolini, I, Ringressi, M, Tirloni, L, Laface, L, Abate, E, Casati, M, Gobbi, P, Opocher, E, Mariani, N, Ceretti, A, Giovenzana, M, Giuliani, B, Sironi, M, Grossi, U, Zanus, G, Santoro, G, Brizzolari, M, De Leo, E, Novello, S, Aquilino, K, Milardi, F, Olmi, S, Uccelli, M, Bonaldi, M, Cesana, G, Bindi, M, Galleano, R, Langone, A, Botto, M, Franceschi, A, Gambino, E, Ronconi, M, Casiraghi, S, Casole, G, Ciulla, S, Terrosu, G, Calandra, S, Scarpa, E, Cherchi, V, Martinuzzo, L, Clocchiatti, L, Muschitiello, D, Romanzi, A, Vignati, B, Vannelli, A, Scolaro, R, Milanesi, M, Rossi, F, Canonico, G, Anastasi, A, Nelli, T, Barlettai, M, Fratarcangeli, R, Di Martino, C, Damigella, A, Adinolfi, E, Birindelli, A, Taglietti, L, Dester, S, Fleres, F, Cucinotta, E, Viscosi, F, Biondo, S, Badessi, G, Catarsini, N, Mazzeo, C, Rega, D, Delrio, P, Cervone, C, Aversano, A, De Franciscis, S, Di Marzo, M, Marra, B, Pace, U, Amato, A, Batistotti, P, Mina, E, Serventi, A, Lapolla, P, Mingoli, A, Sapienza, P, Brachini, G, Cirillo, B, Fiori, E, Crocetti, D, Clementi, I, Martines, G, Picciariello, A, Tomasicchio, G, Dibra, R, Trigiante, G, Rinaldi, M, Lantone, G, Porcu, A, Perra, T, Scanu, A, Feo, C, Fancellu, A, Cossu, M, Ginesu, G, Patriti, A, Coletta, D, Petrelli, F, Greco, P, Spadoni, C, Cassiani, G, Bianchini, F, Arganini, M, Bianchini, M, Perotti, B, Palmeri, M, Scabini, S, Deiana, S, Carganico, G, Pertile, D, Soriero, D, Fioravanti, E, Sperotto, B, Nardo, B, Paglione, D, Crocco, V, Doni, M, Osso, M, Perri, R, Sampietro, G, Corbellini, C, Lorusso, L, Manzo, C, Cigognini, M, Baldi, C, Palomba, G, Aprea, G, Capuano, M, Basile, R, Tutino, R, Massani, M, Marinelli, L, Canitano, N, Pilia, T, Podda, M, Pisanu, A, Murzi, V, Incani, S, Frongia, F, Esposito, G, Luglio, G, Tropeano, F, Pagano, G, Spina, E, De Simone, G, Cricri, M, Catena, F, Vallicelli, C, Zanini, N, Ronconi, D, Favi, F, Mazzucchelli, C, Convertini, G, Vincenti, L, Andriola, V, Bizzoca, C, Fabbri, N, Fazzin, M, Pesce, A, Gennari, S, Torchiaro, M, Severi, S, Frontali, A, Bracchetti, G, Granieri, S, Cotsoglou, C, Carlini, M, Lisi, G, Spoletini, D, Mastrangeli, M, Campanelli, M, Manigrasso, M, Milone, M, De Palma, G, Vertaldi, S, Chini, A, Maione, F, Marello, A, Selvaggi, F, Sciaudone, G, Selvaggi, L, Tasselli, F, Fuschillo, G, Oddis, L, Grande, S, Grande, M, Ascanelli, S, Chimisso, L, Aisoni, F, Rossin, E, Pepe, F, Marchetti, F, Picardi, B, Rossi, S, Del Monte, S, Picarelli, M, Muttillo, I, Ratto, C, Marra, A, Parello, A, Litta, F, Campenni, P, De Simone, V, Pata, F, Riboni, C, Rausa, E, Celentano, V, Rottoli M., Spinelli A., Pellino G., Gori A., Calini G., Flacco M. E., Manzoli L., Poggioli G., Romano A., Belvedere A., Lanci A. L., Parlanti D., Vago G., Pezzuto A. P., Canavese A., Dajti G., Cardelli S., Catalioto C., Russo I. S., Violante T., Morezzi D., Maurino L., Filippone E., Cuicchi D., Bernante P., Jovine E., Lombardi R., Masetti M., Cipressi C., Offi M. F., Larotonda C., Puglisi S. B., Barbosa A., Vaiana R., Bianchi P. M., Tonti C., Codignola C., Zorcolo L., Restivo A., Deidda S., Marchetti M. E., Ippolito L., Spolverato G., Pucciarelli S., Marchegiani F., Ghio G., Zagolin G., Glavas D., Tomassi M., Rosati R., Elmore U., Gozzini L., Calef R., Puccetti F., Cossu A., Vignali A., Morino M., Allaix M. E., Cannata G., Lombardi E., Ammirati C. A., Piceni C., Buccianti P., Balestri R., Puccini M., Pezzati D., D'Ischia R., Asta V. F., Sargenti B., Taddei G., Bonari F., Boni G., Ferrero A., Mineccia M., Gonella F., Palisi M., Danese F., Cherubini V., Perotti S., Carvello M., Carbone F., Luberto A., Calafiore E., De Lucia F., Sacchi M., Sasia D., Giuffrida M. C., Ballauri E., Cardile M., Armentano S., Beltrami E., Preve G., Vercellone B., Mozzon M., Folliero C., Lirusso C., Vecchiato M., Ziccarelli A., Gattesco D., Moretti L., Crestale S., Banchini F., Capelli P., Romboli A., Palmieri G., Conti L., Rizzi N., Bonfili D., De Manzini N., Germani P., Osenda E., Cortinovis S., Giunta C., Fracon S., Abdallah H., Bogoni S., Portolani N., Nascimbeni R., Molfino S., Tiberio G. A. M., Garosio I., Lamperti G., Rigosa D., Ercolani G., Solaini L., Cavaliere D., Avanzolini A., D'Acapito F., Chiarella L. L., Di Pietrantonio D., Annunziata D., Piccolo R., Sorrentino M., Pansini M., Cojutti A., Graziano M., Callegari F., Balzarotti L., Dameno V. R., Cattaneo A., Santolamazza G., Altieri C., Magarini R., Pietrabissa A., Dominioni T., Pugliese L., Peri A., Botti M., Salvetti F., Boni L., Cassinotti E., Baldari L., Messina V., D'Abrosca V., Cianci P., Tumolo R., Gattulli D., Restini E., Minafra M., Sederino M. G., Bottalico B., Pilati P., Franzato B., Mattara G., De Simoni O., Barina A., Tonello M., Muratore A., Calabro M., Federico Pipitone N. S., Cuzzola B., Van Nood E. H., Passuello N., Frasson A., Mammano E., Faccio L., Vittadello F., Bressan A., Sarzo G., Tamini N., Oldani M., Cigagna L., Carissimi F., De Carlo G., Baccalini E., Nespoli L., Giordano A., Cantafio S., Grifoni L., Matani D., Livi S., Delogu D., Scognamillo F., Marrosu A., Guerrini L., Ugolini G., Ghignone F., Frascaroli G., Albertini N., Zattoni D., Taffurelli G., Montroni I., Colombo F., Danelli P., Bondurri A., Maffioli A., Bonomi A., Pezzoli I., Cammarata F., Goletti O., Molteni M., Assisi A., Quartierini G., Da Lio C., Verdi D., Mondi I., Peluso C., MacChi L., Tanzanu M., Zanzi F., Pellegrini S., Andreuccetti J., D'Alessio R., Pignata G., De Capua M., Canfora I., Ottaviani L., Lepiane P., Balla A., De Carlo A., Saraceno F., Scaramuzzo R., Guida A., Aguzzi D., Bellora P., Gentilli S., Monni M., Nikaj H., Cillara N., Cannavera A., Deserra A., Margiani C., Cabula R., Dettori M., Gramignano G., Lezoche G., Ortenzi M., Orlandoni E. S., Curzi F., Vitali F., Capomagi P., Palmieri M., Giuffrida M., Del Rio P., Bonati E., Loderer T., Cozzani F., Rossini M., Agnesi S., Capolupo G. T., Caricato M., Carannante F., Masciana G., Marrelli M., Miacci V., Lauricella S., Tonini V., Cervellera M., Pisconti S., Lozito C., Shahu J., Mongelli C., Morelli G., Sartarelli L., Sica G. S., Siragusa L., Bagaglini G., Guida A. M., Franceschilli M., Bellato V., Fiorani C., Taddei A., Risaliti M., Bartolini I., Ringressi M. N., Tirloni L., Laface L., Abate E., Casati M., Gobbi P., Opocher E., Mariani N. M., Ceretti A. P., Giovenzana M., Giuliani B., Sironi M., Grossi U., Zanus G., Santoro G. A., Brizzolari M., De Leo E., Novello S., Aquilino K., Milardi F., Olmi S., Uccelli M., Bonaldi M., Cesana G. C., Bindi M., Galleano R., Langone A., Botto M., Franceschi A., Gambino E., Ronconi M., Casiraghi S., Casole G., Ciulla S. L., Terrosu G., Calandra S., Scarpa E., Cherchi V., Martinuzzo L., Clocchiatti L., Muschitiello D., Romanzi A., Vignati B., Vannelli A., Scolaro R., Milanesi M., Rossi F., Canonico G., Anastasi A., Nelli T., Barlettai M., Fratarcangeli R., Di Martino C., Damigella A., Adinolfi E., Birindelli A., Taglietti L., Dester S. E., Fleres F., Cucinotta E., Viscosi F., Biondo S. A., Badessi G., Catarsini N., Mazzeo C., Rega D., Delrio P., Cervone C., Aversano A., De Franciscis S., Di Marzo M., Marra B., Pace U., Amato A., Batistotti P., Mina E., Serventi A., Lapolla P., Mingoli A., Sapienza P., Brachini G., Cirillo B., Fiori E., Crocetti D., Clementi I., Martines G., Picciariello A., Tomasicchio G., Dibra R., Trigiante G., Rinaldi M., Lantone G., Porcu A., Perra T., Scanu A. M., Feo C. F., Fancellu A., Cossu M. L., Ginesu G. C., Patriti A., Coletta D., Petrelli F., Greco P. A., Spadoni C., Cassiani G., Bianchini F., Arganini M., Bianchini M., Perotti B., Palmeri M., Scabini S., Deiana S., Carganico G., Pertile D., Soriero D., Fioravanti E., Sperotto B., Nardo B., Paglione D., Crocco V., Doni M., Osso M., Perri R., Sampietro G. M., Corbellini C., Lorusso L., Manzo C. A., Cigognini M., Baldi C., Palomba G., Aprea G., Capuano M., Basile R., Tutino R., Massani M., Marinelli L., Canitano N., Pilia T., Podda M., Pisanu A., Murzi V., Incani S., Frongia F., Esposito G., Luglio G., Tropeano F. P., Pagano G., Spina E., De Simone G., Cricri M., Catena F., Vallicelli C., Zanini N., Ronconi D., Favi F., Mazzucchelli C., Convertini G., Vincenti L., Andriola V., Bizzoca C., Feo C. V., Fabbri N., Fazzin M., Pesce A., Gennari S., Torchiaro M., Severi S., Frontali A., Bracchetti G., Granieri S., Cotsoglou C., Carlini M., Lisi G., Spoletini D., Mastrangeli M. R., Campanelli M., Manigrasso M., Milone M., De Palma G. D., Vertaldi S., Chini A., Maione F., Marello A., Selvaggi F., Sciaudone G., Selvaggi L., Tasselli F. M., Fuschillo G., Oddis L., Grande S., Grande M., Ascanelli S., Chimisso L., Aisoni F., Rossin E., Pepe F., Marchetti F., Picardi B., Rossi S., Del Monte S. R., Picarelli M., Muttillo I. A., Ratto C., Marra A. A., Parello A., Litta F., Campenni P., De Simone V., Pata F., Riboni C., Rausa E., Celentano V., Rottoli, M, Spinelli, A, Pellino, G, Gori, A, Calini, G, Flacco, M, Manzoli, L, Poggioli, G, Romano, A, Belvedere, A, Lanci, A, Parlanti, D, Vago, G, Pezzuto, A, Canavese, A, Dajti, G, Cardelli, S, Catalioto, C, Russo, I, Violante, T, Morezzi, D, Maurino, L, Filippone, E, Cuicchi, D, Bernante, P, Jovine, E, Lombardi, R, Masetti, M, Cipressi, C, Offi, M, Larotonda, C, Puglisi, S, Barbosa, A, Vaiana, R, Bianchi, P, Tonti, C, Codignola, C, Zorcolo, L, Restivo, A, Deidda, S, Marchetti, M, Ippolito, L, Spolverato, G, Pucciarelli, S, Marchegiani, F, Ghio, G, Zagolin, G, Glavas, D, Tomassi, M, Rosati, R, Elmore, U, Gozzini, L, Calef, R, Puccetti, F, Cossu, A, Vignali, A, Morino, M, Allaix, M, Cannata, G, Lombardi, E, Ammirati, C, Piceni, C, Buccianti, P, Balestri, R, Puccini, M, Pezzati, D, D'Ischia, R, Asta, V, Sargenti, B, Taddei, G, Bonari, F, Boni, G, Ferrero, A, Mineccia, M, Gonella, F, Palisi, M, Danese, F, Cherubini, V, Perotti, S, Carvello, M, Carbone, F, Luberto, A, Calafiore, E, De Lucia, F, Sacchi, M, Sasia, D, Giuffrida, M, Ballauri, E, Cardile, M, Armentano, S, Beltrami, E, Preve, G, Vercellone, B, Mozzon, M, Folliero, C, Lirusso, C, Vecchiato, M, Ziccarelli, A, Gattesco, D, Moretti, L, Crestale, S, Banchini, F, Capelli, P, Romboli, A, Palmieri, G, Conti, L, Rizzi, N, Bonfili, D, De Manzini, N, Germani, P, Osenda, E, Cortinovis, S, Giunta, C, Fracon, S, Abdallah, H, Bogoni, S, Portolani, N, Nascimbeni, R, Molfino, S, Tiberio, G, Garosio, I, Lamperti, G, Rigosa, D, Ercolani, G, Solaini, L, Cavaliere, D, Avanzolini, A, D'Acapito, F, Chiarella, L, Di Pietrantonio, D, Annunziata, D, Piccolo, R, Sorrentino, M, Pansini, M, Cojutti, A, Graziano, M, Callegari, F, Balzarotti, L, Dameno, V, Cattaneo, A, Santolamazza, G, Altieri, C, Magarini, R, Pietrabissa, A, Dominioni, T, Pugliese, L, Peri, A, Botti, M, Salvetti, F, Boni, L, Cassinotti, E, Baldari, L, Messina, V, D'Abrosca, V, Cianci, P, Tumolo, R, Gattulli, D, Restini, E, Minafra, M, Sederino, M, Bottalico, B, Pilati, P, Franzato, B, Mattara, G, De Simoni, O, Barina, A, Tonello, M, Muratore, A, Calabro, M, Federico Pipitone, N, Cuzzola, B, Van Nood, E, Passuello, N, Frasson, A, Mammano, E, Faccio, L, Vittadello, F, Bressan, A, Sarzo, G, Tamini, N, Oldani, M, Cigagna, L, Carissimi, F, De Carlo, G, Baccalini, E, Nespoli, L, Giordano, A, Cantafio, S, Grifoni, L, Matani, D, Livi, S, Delogu, D, Scognamillo, F, Marrosu, A, Guerrini, L, Ugolini, G, Ghignone, F, Frascaroli, G, Albertini, N, Zattoni, D, Taffurelli, G, Montroni, I, Colombo, F, Danelli, P, Bondurri, A, Maffioli, A, Bonomi, A, Pezzoli, I, Cammarata, F, Goletti, O, Molteni, M, Assisi, A, Quartierini, G, Da Lio, C, Verdi, D, Mondi, I, Peluso, C, Macchi, L, Tanzanu, M, Zanzi, F, Pellegrini, S, Andreuccetti, J, D'Alessio, R, Pignata, G, De Capua, M, Canfora, I, Ottaviani, L, Lepiane, P, Balla, A, De Carlo, A, Saraceno, F, Scaramuzzo, R, Guida, A, Aguzzi, D, Bellora, P, Gentilli, S, Monni, M, Nikaj, H, Cillara, N, Cannavera, A, Deserra, A, Margiani, C, Cabula, R, Dettori, M, Gramignano, G, Lezoche, G, Ortenzi, M, Orlandoni, E, Curzi, F, Vitali, F, Capomagi, P, Palmieri, M, Del Rio, P, Bonati, E, Loderer, T, Cozzani, F, Rossini, M, Agnesi, S, Capolupo, G, Caricato, M, Carannante, F, Masciana, G, Marrelli, M, Miacci, V, Lauricella, S, Tonini, V, Cervellera, M, Pisconti, S, Lozito, C, Shahu, J, Mongelli, C, Morelli, G, Sartarelli, L, Sica, G, Siragusa, L, Bagaglini, G, Franceschilli, M, Bellato, V, Fiorani, C, Taddei, A, Risaliti, M, Bartolini, I, Ringressi, M, Tirloni, L, Laface, L, Abate, E, Casati, M, Gobbi, P, Opocher, E, Mariani, N, Ceretti, A, Giovenzana, M, Giuliani, B, Sironi, M, Grossi, U, Zanus, G, Santoro, G, Brizzolari, M, De Leo, E, Novello, S, Aquilino, K, Milardi, F, Olmi, S, Uccelli, M, Bonaldi, M, Cesana, G, Bindi, M, Galleano, R, Langone, A, Botto, M, Franceschi, A, Gambino, E, Ronconi, M, Casiraghi, S, Casole, G, Ciulla, S, Terrosu, G, Calandra, S, Scarpa, E, Cherchi, V, Martinuzzo, L, Clocchiatti, L, Muschitiello, D, Romanzi, A, Vignati, B, Vannelli, A, Scolaro, R, Milanesi, M, Rossi, F, Canonico, G, Anastasi, A, Nelli, T, Barlettai, M, Fratarcangeli, R, Di Martino, C, Damigella, A, Adinolfi, E, Birindelli, A, Taglietti, L, Dester, S, Fleres, F, Cucinotta, E, Viscosi, F, Biondo, S, Badessi, G, Catarsini, N, Mazzeo, C, Rega, D, Delrio, P, Cervone, C, Aversano, A, De Franciscis, S, Di Marzo, M, Marra, B, Pace, U, Amato, A, Batistotti, P, Mina, E, Serventi, A, Lapolla, P, Mingoli, A, Sapienza, P, Brachini, G, Cirillo, B, Fiori, E, Crocetti, D, Clementi, I, Martines, G, Picciariello, A, Tomasicchio, G, Dibra, R, Trigiante, G, Rinaldi, M, Lantone, G, Porcu, A, Perra, T, Scanu, A, Feo, C, Fancellu, A, Cossu, M, Ginesu, G, Patriti, A, Coletta, D, Petrelli, F, Greco, P, Spadoni, C, Cassiani, G, Bianchini, F, Arganini, M, Bianchini, M, Perotti, B, Palmeri, M, Scabini, S, Deiana, S, Carganico, G, Pertile, D, Soriero, D, Fioravanti, E, Sperotto, B, Nardo, B, Paglione, D, Crocco, V, Doni, M, Osso, M, Perri, R, Sampietro, G, Corbellini, C, Lorusso, L, Manzo, C, Cigognini, M, Baldi, C, Palomba, G, Aprea, G, Capuano, M, Basile, R, Tutino, R, Massani, M, Marinelli, L, Canitano, N, Pilia, T, Podda, M, Pisanu, A, Murzi, V, Incani, S, Frongia, F, Esposito, G, Luglio, G, Tropeano, F, Pagano, G, Spina, E, De Simone, G, Cricri, M, Catena, F, Vallicelli, C, Zanini, N, Ronconi, D, Favi, F, Mazzucchelli, C, Convertini, G, Vincenti, L, Andriola, V, Bizzoca, C, Fabbri, N, Fazzin, M, Pesce, A, Gennari, S, Torchiaro, M, Severi, S, Frontali, A, Bracchetti, G, Granieri, S, Cotsoglou, C, Carlini, M, Lisi, G, Spoletini, D, Mastrangeli, M, Campanelli, M, Manigrasso, M, Milone, M, De Palma, G, Vertaldi, S, Chini, A, Maione, F, Marello, A, Selvaggi, F, Sciaudone, G, Selvaggi, L, Tasselli, F, Fuschillo, G, Oddis, L, Grande, S, Grande, M, Ascanelli, S, Chimisso, L, Aisoni, F, Rossin, E, Pepe, F, Marchetti, F, Picardi, B, Rossi, S, Del Monte, S, Picarelli, M, Muttillo, I, Ratto, C, Marra, A, Parello, A, Litta, F, Campenni, P, De Simone, V, Pata, F, Riboni, C, Rausa, E, Celentano, V, Rottoli M., Spinelli A., Pellino G., Gori A., Calini G., Flacco M. E., Manzoli L., Poggioli G., Romano A., Belvedere A., Lanci A. L., Parlanti D., Vago G., Pezzuto A. P., Canavese A., Dajti G., Cardelli S., Catalioto C., Russo I. S., Violante T., Morezzi D., Maurino L., Filippone E., Cuicchi D., Bernante P., Jovine E., Lombardi R., Masetti M., Cipressi C., Offi M. F., Larotonda C., Puglisi S. B., Barbosa A., Vaiana R., Bianchi P. M., Tonti C., Codignola C., Zorcolo L., Restivo A., Deidda S., Marchetti M. E., Ippolito L., Spolverato G., Pucciarelli S., Marchegiani F., Ghio G., Zagolin G., Glavas D., Tomassi M., Rosati R., Elmore U., Gozzini L., Calef R., Puccetti F., Cossu A., Vignali A., Morino M., Allaix M. E., Cannata G., Lombardi E., Ammirati C. A., Piceni C., Buccianti P., Balestri R., Puccini M., Pezzati D., D'Ischia R., Asta V. F., Sargenti B., Taddei G., Bonari F., Boni G., Ferrero A., Mineccia M., Gonella F., Palisi M., Danese F., Cherubini V., Perotti S., Carvello M., Carbone F., Luberto A., Calafiore E., De Lucia F., Sacchi M., Sasia D., Giuffrida M. C., Ballauri E., Cardile M., Armentano S., Beltrami E., Preve G., Vercellone B., Mozzon M., Folliero C., Lirusso C., Vecchiato M., Ziccarelli A., Gattesco D., Moretti L., Crestale S., Banchini F., Capelli P., Romboli A., Palmieri G., Conti L., Rizzi N., Bonfili D., De Manzini N., Germani P., Osenda E., Cortinovis S., Giunta C., Fracon S., Abdallah H., Bogoni S., Portolani N., Nascimbeni R., Molfino S., Tiberio G. A. M., Garosio I., Lamperti G., Rigosa D., Ercolani G., Solaini L., Cavaliere D., Avanzolini A., D'Acapito F., Chiarella L. L., Di Pietrantonio D., Annunziata D., Piccolo R., Sorrentino M., Pansini M., Cojutti A., Graziano M., Callegari F., Balzarotti L., Dameno V. R., Cattaneo A., Santolamazza G., Altieri C., Magarini R., Pietrabissa A., Dominioni T., Pugliese L., Peri A., Botti M., Salvetti F., Boni L., Cassinotti E., Baldari L., Messina V., D'Abrosca V., Cianci P., Tumolo R., Gattulli D., Restini E., Minafra M., Sederino M. G., Bottalico B., Pilati P., Franzato B., Mattara G., De Simoni O., Barina A., Tonello M., Muratore A., Calabro M., Federico Pipitone N. S., Cuzzola B., Van Nood E. H., Passuello N., Frasson A., Mammano E., Faccio L., Vittadello F., Bressan A., Sarzo G., Tamini N., Oldani M., Cigagna L., Carissimi F., De Carlo G., Baccalini E., Nespoli L., Giordano A., Cantafio S., Grifoni L., Matani D., Livi S., Delogu D., Scognamillo F., Marrosu A., Guerrini L., Ugolini G., Ghignone F., Frascaroli G., Albertini N., Zattoni D., Taffurelli G., Montroni I., Colombo F., Danelli P., Bondurri A., Maffioli A., Bonomi A., Pezzoli I., Cammarata F., Goletti O., Molteni M., Assisi A., Quartierini G., Da Lio C., Verdi D., Mondi I., Peluso C., MacChi L., Tanzanu M., Zanzi F., Pellegrini S., Andreuccetti J., D'Alessio R., Pignata G., De Capua M., Canfora I., Ottaviani L., Lepiane P., Balla A., De Carlo A., Saraceno F., Scaramuzzo R., Guida A., Aguzzi D., Bellora P., Gentilli S., Monni M., Nikaj H., Cillara N., Cannavera A., Deserra A., Margiani C., Cabula R., Dettori M., Gramignano G., Lezoche G., Ortenzi M., Orlandoni E. S., Curzi F., Vitali F., Capomagi P., Palmieri M., Giuffrida M., Del Rio P., Bonati E., Loderer T., Cozzani F., Rossini M., Agnesi S., Capolupo G. T., Caricato M., Carannante F., Masciana G., Marrelli M., Miacci V., Lauricella S., Tonini V., Cervellera M., Pisconti S., Lozito C., Shahu J., Mongelli C., Morelli G., Sartarelli L., Sica G. S., Siragusa L., Bagaglini G., Guida A. M., Franceschilli M., Bellato V., Fiorani C., Taddei A., Risaliti M., Bartolini I., Ringressi M. N., Tirloni L., Laface L., Abate E., Casati M., Gobbi P., Opocher E., Mariani N. M., Ceretti A. P., Giovenzana M., Giuliani B., Sironi M., Grossi U., Zanus G., Santoro G. A., Brizzolari M., De Leo E., Novello S., Aquilino K., Milardi F., Olmi S., Uccelli M., Bonaldi M., Cesana G. C., Bindi M., Galleano R., Langone A., Botto M., Franceschi A., Gambino E., Ronconi M., Casiraghi S., Casole G., Ciulla S. L., Terrosu G., Calandra S., Scarpa E., Cherchi V., Martinuzzo L., Clocchiatti L., Muschitiello D., Romanzi A., Vignati B., Vannelli A., Scolaro R., Milanesi M., Rossi F., Canonico G., Anastasi A., Nelli T., Barlettai M., Fratarcangeli R., Di Martino C., Damigella A., Adinolfi E., Birindelli A., Taglietti L., Dester S. E., Fleres F., Cucinotta E., Viscosi F., Biondo S. A., Badessi G., Catarsini N., Mazzeo C., Rega D., Delrio P., Cervone C., Aversano A., De Franciscis S., Di Marzo M., Marra B., Pace U., Amato A., Batistotti P., Mina E., Serventi A., Lapolla P., Mingoli A., Sapienza P., Brachini G., Cirillo B., Fiori E., Crocetti D., Clementi I., Martines G., Picciariello A., Tomasicchio G., Dibra R., Trigiante G., Rinaldi M., Lantone G., Porcu A., Perra T., Scanu A. M., Feo C. F., Fancellu A., Cossu M. L., Ginesu G. C., Patriti A., Coletta D., Petrelli F., Greco P. A., Spadoni C., Cassiani G., Bianchini F., Arganini M., Bianchini M., Perotti B., Palmeri M., Scabini S., Deiana S., Carganico G., Pertile D., Soriero D., Fioravanti E., Sperotto B., Nardo B., Paglione D., Crocco V., Doni M., Osso M., Perri R., Sampietro G. M., Corbellini C., Lorusso L., Manzo C. A., Cigognini M., Baldi C., Palomba G., Aprea G., Capuano M., Basile R., Tutino R., Massani M., Marinelli L., Canitano N., Pilia T., Podda M., Pisanu A., Murzi V., Incani S., Frongia F., Esposito G., Luglio G., Tropeano F. P., Pagano G., Spina E., De Simone G., Cricri M., Catena F., Vallicelli C., Zanini N., Ronconi D., Favi F., Mazzucchelli C., Convertini G., Vincenti L., Andriola V., Bizzoca C., Feo C. V., Fabbri N., Fazzin M., Pesce A., Gennari S., Torchiaro M., Severi S., Frontali A., Bracchetti G., Granieri S., Cotsoglou C., Carlini M., Lisi G., Spoletini D., Mastrangeli M. R., Campanelli M., Manigrasso M., Milone M., De Palma G. D., Vertaldi S., Chini A., Maione F., Marello A., Selvaggi F., Sciaudone G., Selvaggi L., Tasselli F. M., Fuschillo G., Oddis L., Grande S., Grande M., Ascanelli S., Chimisso L., Aisoni F., Rossin E., Pepe F., Marchetti F., Picardi B., Rossi S., Del Monte S. R., Picarelli M., Muttillo I. A., Ratto C., Marra A. A., Parello A., Litta F., Campenni P., De Simone V., Pata F., Riboni C., Rausa E., and Celentano V.

Abstract

Background: The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. The aim of the study was to assess the association between centre volume and severe complications, mortality, less-than-radical oncologic surgery, and indications for neoadjuvant therapy. Methods: Retrospective analysis of 16,883 colorectal cancer cases from 80 centres (2018-2021). Outcomes: 30-day mortality; Clavien-Dindo grade >2 complications; removal of ≥ 12 lymph nodes; non-radical resection; neoadjuvant therapy. Quartiles of hospital volumes were classified as LOW, MEDIUM, HIGH, and VERY HIGH. Independent predictors, both overall and for rectal cancer, were evaluated using logistic regression including age, gender, AJCC stage and cancer site. Results: LOW-volume centres reported a higher rate of severe postoperative complications (OR 1.50, 95% c.i. 1.15-1.096, P = 0.003). The rate of ≥ 12 lymph nodes removed in LOW-volume (OR 0.68, 95% c.i. 0.56-0.85, P < 0.001) and MEDIUM-volume (OR 0.72, 95% c.i. 0.62-0.83, P < 0.001) centres was lower than in VERY HIGH-volume centres. Of the 4676 rectal cancer patients, the rate of ≥ 12 lymph nodes removed was lower in LOW-volume than in VERY HIGH-volume centres (OR 0.57, 95% c.i. 0.41-0.80, P = 0.001). A lower rate of neoadjuvant chemoradiation was associated with HIGH (OR 0.66, 95% c.i. 0.56-0.77, P < 0.001), MEDIUM (OR 0.75, 95% c.i. 0.60-0.92, P = 0.006), and LOW (OR 0.70, 95% c.i. 0.52-0.94, P = 0.019) volume centres (vs. VERY HIGH). Conclusion: Colorectal cancer surgery in low-volume centres is at higher risk of suboptimal management, poor postoperative outcomes, and less-than-adequate oncologic resections. Centralisation of rectal cancer cases should be taken into consideration to optimise the outcomes.

Published
2024

4. Open versus laparoscopic gastrectomy for advanced gastric cancer: a propensity score matching analysis of survival in a western population—on behalf of the Italian Research Group for Gastric Cancer

Author

Lombardi, P, Bernasconi, D, Baiocchi, G, Berselli, M, Biondi, A, Castoro, C, Catarci, M, Degiuli, M, Fumagalli Romario, U, Giacopuzzi, S, Marchesi, F, Marrelli, D, Mazzola, M, Molfino, S, Olmi, S, Rausei, S, Rosa, F, Rosati, R, Roviello, F, Santi, S, Solaini, L, Staderini, F, Vigano, J, Ferrari, G, Agnes, A, Alfieri, S, Alloggio, M, Bencivenga, M, Benedetti, M, Bottari, A, Cianchi, F, Cocozza, E, Dalmonte, G, De Martini, P, De Pascale, S, Desio, M, Emiliani, G, Ercolani, G, Galli, F, Garosio, I, Giani, A, Gualtierotti, M, Marano, L, Morgagni, P, Peri, A, Puccetti, F, Reddavid, R, Uccelli, M, Lombardi P. M., Bernasconi D., Baiocchi G. L., Berselli M., Biondi A., Castoro C., Catarci M., Degiuli M., Fumagalli Romario U., Giacopuzzi S., Marchesi F., Marrelli D., Mazzola M., Molfino S., Olmi S., Rausei S., Rosa F., Rosati R., Roviello F., Santi S., Solaini L., Staderini F., Vigano J., Ferrari G., Agnes A., Alfieri S., Alloggio M., Bencivenga M., Benedetti M., Bottari A., Cianchi F., Cocozza E., Dalmonte G., De Martini P., De Pascale S., Desio M., Emiliani G., Ercolani G., Galli F., Garosio I., Giani A., Gualtierotti M., Marano L., Morgagni P., Peri A., Puccetti F., Reddavid R., Uccelli M., Lombardi, P, Bernasconi, D, Baiocchi, G, Berselli, M, Biondi, A, Castoro, C, Catarci, M, Degiuli, M, Fumagalli Romario, U, Giacopuzzi, S, Marchesi, F, Marrelli, D, Mazzola, M, Molfino, S, Olmi, S, Rausei, S, Rosa, F, Rosati, R, Roviello, F, Santi, S, Solaini, L, Staderini, F, Vigano, J, Ferrari, G, Agnes, A, Alfieri, S, Alloggio, M, Bencivenga, M, Benedetti, M, Bottari, A, Cianchi, F, Cocozza, E, Dalmonte, G, De Martini, P, De Pascale, S, Desio, M, Emiliani, G, Ercolani, G, Galli, F, Garosio, I, Giani, A, Gualtierotti, M, Marano, L, Morgagni, P, Peri, A, Puccetti, F, Reddavid, R, Uccelli, M, Lombardi P. M., Bernasconi D., Baiocchi G. L., Berselli M., Biondi A., Castoro C., Catarci M., Degiuli M., Fumagalli Romario U., Giacopuzzi S., Marchesi F., Marrelli D., Mazzola M., Molfino S., Olmi S., Rausei S., Rosa F., Rosati R., Roviello F., Santi S., Solaini L., Staderini F., Vigano J., Ferrari G., Agnes A., Alfieri S., Alloggio M., Bencivenga M., Benedetti M., Bottari A., Cianchi F., Cocozza E., Dalmonte G., De Martini P., De Pascale S., Desio M., Emiliani G., Ercolani G., Galli F., Garosio I., Giani A., Gualtierotti M., Marano L., Morgagni P., Peri A., Puccetti F., Reddavid R., and Uccelli M.

Abstract

Background: Oncologic outcomes after laparoscopic gastrectomy for advanced gastric cancer in the West have been poorly investigated. The aim of the present study was to compare survival outcomes in patients undergoing curative-intent laparoscopic and open gastrectomy for advanced gastric cancer in several centres belonging to the Italian Research Group for Gastric Cancer. Methods: Data of patients operated between 2015 and 2018 were retrospectively analysed. Propensity Score Matching was performed to balance baseline characteristics of patients undergoing laparoscopic and open gastrectomy. The primary endpoint was 3-year overall survival. Secondary endpoints were 3-year disease-free survival and short-term outcomes. Multivariable regression analyses for survival were conducted. Results: Data were retrieved from 20 centres. Of the 717 patients included, 438 patients were correctly matched, 219 per group. The 3-year overall survival was 73.6% and 68.7% in the laparoscopic and open group, respectively (p = 0.40). When compared with open gastrectomy, laparoscopic gastrectomy showed comparable 3-year disease-free survival (62.8%, vs 58.9%, p = 0.40), higher rate of return to intended oncologic treatment (56.9% vs 40.2%, p = 0.001), similar 30-day morbidity/mortality. Prognostic factors for survival were ASA Score ≥ 3, age-adjusted Charlson Comorbidity Index ≥ 5, lymph node ratio ≥ 0.15, p/ypTNM Stage III and return to intended oncologic treatment. Conclusions: Laparoscopic gastrectomy for advanced gastric cancer offers similar rates of survival when compared to open gastrectomy, with higher rates of return to intended oncologic treatment. ASA score, age-adjusted Charlson Comorbidity Index, lymph node ratio, return to intended oncologic treatment and p/ypTNM Stage, but not surgical approach, are prognostic factors for survival.

Published
2022

5. Systematic review and meta-analysis: endoscopic vacuum therapy (evt) versus self-expandable metal stent (sems) for anastomotic leaks after upper gastrointestinal surgery

Author

Mandarino, F. V., additional, Barchi, A., additional, Fanti, L., additional, Azzolini, F., additional, Rosati, R., additional, Bemelman, W. A., additional, Fiorino, G., additional, Elmore, U., additional, Barbieri, L., additional, Puccetti, F., additional, Biamonte, P., additional, Napolitano, M., additional, Fasulo, E., additional, and Danese, S., additional

Published
2023
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6. T.08.2 SYSTEMATIC REVIEW AND META-ANALYSIS: ENDOSCOPIC VACUUM THERAPY (EVT) VERSUS SELF-EXPANDABLE METAL STENT (SEMS) FOR ANASTOMOTIC LEAKS AFTER UPPER GASTROINTESTINAL SURGERY

Author

Mandarino, F.V., primary, Barchi, A., additional, Fanti, L., additional, Azzolini, F., additional, Rosati, R., additional, Bemelman, W., additional, Fiorino, G., additional, Elmore, U., additional, Barbieri, L., additional, Puccetti, F., additional, Biamonte, P., additional, Napolitano, M., additional, Fasulo, E., additional, and Danese, S., additional

Published
2023
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7. Correction: ERas and COLorectal endoscopic surgery: an Italian society for endoscopic surgery and new technologies (SICE) national report (Surgical Endoscopy, (2022), 10.1007/s00464-022-09212-y)

Author

Milone M., Elmore U., Manigrasso M., Ortenzi M., Botteri E., Arezzo A., Silecchia G., Guerrieri M., De Palma G. D., Agresta F., Pizza F., D'Antonio D., Amalfitano F., Selvaggi F., Sciaudone G., Selvaggi L., Prando D., Cavallo F., Lezoche G., Cuccurullo D., Tartaglia E., Sagnelli C., Coratti A., Tribuzi A., Di Marino M., Anania G., Bombardini C., Zago M. P., Tagliabue F., Burati M., Di Saverio S., Colombo S., El Adla S., De Luca M., Zese M., Parini D., Prosperi P., Alemanno G., Martellucci J., Olmi S., Oldani A., Uccelli M., Bono D., Scaglione D., Saracco R., Podda M., Pisanu A., Murzi V., Agrusa A., Buscemi S., Muttillo I. A., Picardi B., Muttillo E. M., Solaini L., Cavaliere D., Ercolani G., Corcione F., Peltrini R., Bracale U., Lucchi A., Vittori L., Grassia M., Porcu A., Perra T., Feo C., Angelini P., Izzo D., Ricciardelli L., Trompetto M., Gallo G., Luc A. R., Muratore A., Calabro M., Cuzzola B., Barberis A., Costanzo F., Angelini G., Ceccarelli G., Rondelli F., De Rosa M., Cassinotti E., Boni L., Baldari L., Bianchi P. P., Formisano G., Giuliani G., Ceretti A. A. P., Mariani N. M., Giovenzana M., Farfaglia R., Marciano P., Arizzi V., Piccoli M., Pecchini F., Pattacini G. C., Vettoretto N., Guarnieri C., Laface L., Abate E., Casati M., Fabri N., Pesce A., Maida P., Marte G., Abete R., Casali L., Marchignoli A., Dall'Aglio M., Scabini S., Pertile D., Aprile A., Andreuccetti J., Di Leo A., Crepaz L., Maione F., Vertaldi S., Chini A., Rosati R., Puccetti F., Maggi G., Cossu A., Sartori A., Piatto G., Perrotta N., Celiento M., Scorzelli M., Pilone V., Tramontano S., Calabrese P., Sechi R., Cillara N., Putzu G., Podda M. G., Montuori M., Pinotti E., Sica G., Franceschilli M., Sensi B., Degiuli M., Reddavid R., Puca L., Farsi M., Minuzzo A., Gia E., Baiocchi G. L., Ranieri V., Celotti A., Bianco F., Grassia S., Novi A., Milone M., Elmore U., Manigrasso M., Ortenzi M., Botteri E., Arezzo A., Silecchia G., Guerrieri M., De Palma G.D., Agresta F., Pizza F., D'Antonio D., Amalfitano F., Selvaggi F., Sciaudone G., Selvaggi L., Prando D., Cavallo F., Lezoche G., Cuccurullo D., Tartaglia E., Sagnelli C., Coratti A., Tribuzi A., Di Marino M., Anania G., Bombardini C., Zago M.P., Tagliabue F., Burati M., Di Saverio S., Colombo S., El Adla S., De Luca M., Zese M., Parini D., Prosperi P., Alemanno G., Martellucci J., Olmi S., Oldani A., Uccelli M., Bono D., Scaglione D., Saracco R., Podda M., Pisanu A., Murzi V., Agrusa A., Buscemi S., Muttillo I.A., Picardi B., Muttillo E.M., Solaini L., Cavaliere D., Ercolani G., Corcione F., Peltrini R., Bracale U., Lucchi A., Vittori L., Grassia M., Porcu A., Perra T., Feo C., Angelini P., Izzo D., Ricciardelli L., Trompetto M., Gallo G., Luc A.R., Muratore A., Calabro M., Cuzzola B., Barberis A., Costanzo F., Angelini G., Ceccarelli G., Rondelli F., De Rosa M., Cassinotti E., Boni L., Baldari L., Bianchi P.P., Formisano G., Giuliani G., Ceretti A.A.P., Mariani N.M., Giovenzana M., Farfaglia R., Marciano P., Arizzi V., Piccoli M., Pecchini F., Pattacini G.C., Vettoretto N., Guarnieri C., Laface L., Abate E., Casati M., Fabri N., Pesce A., Maida P., Marte G., Abete R., Casali L., Marchignoli A., Dall'Aglio M., Scabini S., Pertile D., Aprile A., Andreuccetti J., Di Leo A., Crepaz L., Maione F., Vertaldi S., Chini A., Rosati R., Puccetti F., Maggi G., Cossu A., Sartori A., Piatto G., Perrotta N., Celiento M., Scorzelli M., Pilone V., Tramontano S., Calabrese P., Sechi R., Cillara N., Putzu G., Podda M.G., Montuori M., Pinotti E., Sica G., Franceschilli M., Sensi B., Degiuli M., Reddavid R., Puca L., Farsi M., Minuzzo A., Gia E., Baiocchi G.L., Ranieri V., Celotti A., Bianco F., Grassia S., and Novi A.

Subjects
Settore MED/18 - Chirurgia Generale, Colorectal ERAS ·Enhanced Recovery Minimally invasive
Abstract

This article was updated to correct Nicolò Fabbri's name in the listing of the ERCOLE Study Group (in Acknowledgments).

Published
2022

8. Correction: ERas and COLorectal endoscopic surgery: an Italian society for endoscopic surgery and new technologies (SICE) national report (Surgical Endoscopy, (2022), 36, 10, (7619-7627), 10.1007/s00464-022-09212-y)

Author

Milone M., Elmore U., Manigrasso M., Ortenzi M., Botteri E., Arezzo A., Silecchia G., Guerrieri M., De Palma G. D., Agresta F., Pizza F., D'Antonio D., Amalfitano F., Selvaggi F., Sciaudone G., Selvaggi L., Prando D., Cavallo F., Lezoche G., Cuccurullo D., Tartaglia E., Sagnelli C., Coratti A., Tribuzi A., Di Marino M., Anania G., Bombardini C., Zago M. P., Tagliabue F., Burati M., Di Saverio S., Colombo S., El Adla S., De Luca M., Zese M., Parini D., Prosperi P., Alemanno G., Martellucci J., Olmi S., Oldani A., Uccelli M., Bono D., Scaglione D., Saracco R., Podda M., Pisanu A., Murzi V., Agrusa A., Buscemi S., Muttillo I. A., Picardi B., Muttillo E. M., Solaini L., Cavaliere D., Ercolani G., Corcione F., Peltrini R., Bracale U., Lucchi A., Vittori L., Grassia M., Porcu A., Perra T., Feo C., Angelini P., Izzo D., Ricciardelli L., Trompetto M., Gallo G., Luc A. R., Muratore A., Calabro M., Cuzzola B., Barberis A., Costanzo F., Angelini G., Ceccarelli G., Rondelli F., De Rosa M., Cassinotti E., Boni L., Baldari L., Bianchi P. P., Formisano G., Giuliani G., Ceretti A. A. P., Mariani N. M., Giovenzana M., Farfaglia R., Marciano P., Arizzi V., Piccoli M., Pecchini F., Pattacini G. C., Vettoretto N., Guarnieri C., Laface L., Abate E., Casati M., Fabri N., Pesce A., Maida P., Marte G., Abete R., Casali L., Marchignoli A., Dall'Aglio M., Scabini S., Pertile D., Aprile A., Andreuccetti J., Di Leo A., Crepaz L., Maione F., Vertaldi S., Chini A., Rosati R., Puccetti F., Maggi G., Cossu A., Sartori A., Piatto G., Perrotta N., Celiento M., Scorzelli M., Pilone V., Tramontano S., Calabrese P., Sechi R., Cillara N., Putzu G., Podda M. G., Montuori M., Pinotti E., Sica G., Franceschilli M., Sensi B., Degiuli M., Reddavid R., Puca L., Farsi M., Minuzzo A., Gia E., Baiocchi G. L., Ranieri V., Celotti A., Bianco F., Grassia S., Novi A., Milone, M., Elmore, U., Manigrasso, M., Ortenzi, M., Botteri, E., Arezzo, A., Silecchia, G., Guerrieri, M., De Palma, G. D., Agresta, F., Pizza, F., D'Antonio, D., Amalfitano, F., Selvaggi, F., Sciaudone, G., Selvaggi, L., Prando, D., Cavallo, F., Lezoche, G., Cuccurullo, D., Tartaglia, E., Sagnelli, C., Coratti, A., Tribuzi, A., Di Marino, M., Anania, G., Bombardini, C., Zago, M. P., Tagliabue, F., Burati, M., Di Saverio, S., Colombo, S., El Adla, S., De Luca, M., Zese, M., Parini, D., Prosperi, P., Alemanno, G., Martellucci, J., Olmi, S., Oldani, A., Uccelli, M., Bono, D., Scaglione, D., Saracco, R., Podda, M., Pisanu, A., Murzi, V., Agrusa, A., Buscemi, S., Muttillo, I. A., Picardi, B., Muttillo, E. M., Solaini, L., Cavaliere, D., Ercolani, G., Corcione, F., Peltrini, R., Bracale, U., Lucchi, A., Vittori, L., Grassia, M., Porcu, A., Perra, T., Feo, C., Angelini, P., Izzo, D., Ricciardelli, L., Trompetto, M., Gallo, G., Luc, A. R., Muratore, A., Calabro, M., Cuzzola, B., Barberis, A., Costanzo, F., Angelini, G., Ceccarelli, G., Rondelli, F., De Rosa, M., Cassinotti, E., Boni, L., Baldari, L., Bianchi, P. P., Formisano, G., Giuliani, G., Ceretti, A. A. P., Mariani, N. M., Giovenzana, M., Farfaglia, R., Marciano, P., Arizzi, V., Piccoli, M., Pecchini, F., Pattacini, G. C., Vettoretto, N., Guarnieri, C., Laface, L., Abate, E., Casati, M., Fabri, N., Pesce, A., Maida, P., Marte, G., Abete, R., Casali, L., Marchignoli, A., Dall'Aglio, M., Scabini, S., Pertile, D., Aprile, A., Andreuccetti, J., Di Leo, A., Crepaz, L., Maione, F., Vertaldi, S., Chini, A., Rosati, R., Puccetti, F., Maggi, G., Cossu, A., Sartori, A., Piatto, G., Perrotta, N., Celiento, M., Scorzelli, M., Pilone, V., Tramontano, S., Calabrese, P., Sechi, R., Cillara, N., Putzu, G., Podda, M. G., Montuori, M., Pinotti, E., Sica, G., Franceschilli, M., Sensi, B., Degiuli, M., Reddavid, R., Puca, L., Farsi, M., Minuzzo, A., Gia, E., Baiocchi, G. L., Ranieri, V., Celotti, A., Bianco, F., Grassia, S., and Novi, A.

Abstract

This article was updated to correct Nicolò Fabbri's name in the listing of the ERCOLE Study Group (in Acknowledgments).

Published
2022

9. Open versus laparoscopic gastrectomy for advanced gastric cancer: a propensity score matching analysis of survival in a western population-on behalf of the Italian Research Group for Gastric Cancer

Author

Lombardi, P. M., Bernasconi, D., Baiocchi, G. L., Berselli, M., Biondi, Alberto, Castoro, C., Catarci, Marco, Degiuli, M., Fumagalli Romario, U., Giacopuzzi, S., Marchesi, F., Marrelli, D., Mazzola, M., Molfino, S., Olmi, S., Rausei, S., Rosa, Fausto, Rosati, R., Roviello, F., Santi, Samuele, Solaini, L., Staderini, F., Vigano, J., Ferrari, G., Agnes, Annamaria, Alfieri, Sergio, Alloggio, M., Bencivenga, M., Benedetti, M., Bottari, A., Cianchi, F., Cocozza, E., Dalmonte, G., De Martini, P., De Pascale, S., Desio, M., Emiliani, G., Ercolani, G., Galli, F., Garosio, I., Giani, A., Gualtierotti, M., Marano, L., Morgagni, P., Peri, A., Puccetti, F., Reddavid, R., Uccelli, M., Biondi A. (ORCID:0000-0002-2470-7858), Catarci M., Rosa F. (ORCID:0000-0002-7280-8354), Santi S., Agnes A., Alfieri S. (ORCID:0000-0002-0404-724X), Lombardi, P. M., Bernasconi, D., Baiocchi, G. L., Berselli, M., Biondi, Alberto, Castoro, C., Catarci, Marco, Degiuli, M., Fumagalli Romario, U., Giacopuzzi, S., Marchesi, F., Marrelli, D., Mazzola, M., Molfino, S., Olmi, S., Rausei, S., Rosa, Fausto, Rosati, R., Roviello, F., Santi, Samuele, Solaini, L., Staderini, F., Vigano, J., Ferrari, G., Agnes, Annamaria, Alfieri, Sergio, Alloggio, M., Bencivenga, M., Benedetti, M., Bottari, A., Cianchi, F., Cocozza, E., Dalmonte, G., De Martini, P., De Pascale, S., Desio, M., Emiliani, G., Ercolani, G., Galli, F., Garosio, I., Giani, A., Gualtierotti, M., Marano, L., Morgagni, P., Peri, A., Puccetti, F., Reddavid, R., Uccelli, M., Biondi A. (ORCID:0000-0002-2470-7858), Catarci M., Rosa F. (ORCID:0000-0002-7280-8354), Santi S., Agnes A., and Alfieri S. (ORCID:0000-0002-0404-724X)

Abstract

Background Oncologic outcomes after laparoscopic gastrectomy for advanced gastric cancer in the West have been poorly investigated. The aim of the present study was to compare survival outcomes in patients undergoing curative-intent laparoscopic and open gastrectomy for advanced gastric cancer in several centres belonging to the Italian Research Group for Gastric Cancer. Methods Data of patients operated between 2015 and 2018 were retrospectively analysed. Propensity Score Matching was performed to balance baseline characteristics of patients undergoing laparoscopic and open gastrectomy. The primary endpoint was 3-year overall survival. Secondary endpoints were 3-year disease-free survival and short-term outcomes. Multivariable regression analyses for survival were conducted. Results Data were retrieved from 20 centres. Of the 717 patients included, 438 patients were correctly matched, 219 per group. The 3-year overall survival was 73.6% and 68.7% in the laparoscopic and open group, respectively (p = 0.40). When compared with open gastrectomy, laparoscopic gastrectomy showed comparable 3-year disease-free survival (62.8%, vs 58.9%, p = 0.40), higher rate of return to intended oncologic treatment (56.9% vs 40.2%, p = 0.001), similar 30-day morbidity/mortality. Prognostic factors for survival were ASA Score >= 3, age-adjusted Charlson Comorbidity Index >= 5, lymph node ratio >= 0.15, p/ypTNM Stage III and return to intended oncologic treatment. Conclusions Laparoscopic gastrectomy for advanced gastric cancer offers similar rates of survival when compared to open gastrectomy, with higher rates of return to intended oncologic treatment. ASA score, age-adjusted Charlson Comorbidity Index, lymph node ratio, return to intended oncologic treatment and p/ypTNM Stage, but not surgical approach, are prognostic factors for survival.

Published
2022

10. 179: EARLY PREDICTION OF PATHOLOGICAL RESPONSE TO NEOADJUVANT CHEMORADIOTHERAPY FOR OESOPHAGEAL CANCER USING FULLY HYBRID PET/MR: PRELIMINARY RESULTS

Author

Palumbo, D, primary, Fiorino, C, additional, Mori, M, additional, Picchio, M, additional, Cossu, A, additional, Slim, N, additional, Puccetti, F, additional, Mazza, E, additional, Steidler, S, additional, Di Muzio, N, additional, Cascinu, S, additional, Gianolli, L, additional, Rosati, R, additional, and De Cobelli, F, additional

Published
2022
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11. 196: SARCOPENIA AND PATIENT’S BODY COMPOSITION: NEW MORPHOMETRIC TOOLS TO PREDICT CLINICAL OUTCOME AFTER IVOR-LEWIS ESOPHAGECTOMY

Author

Battaglia, S, primary, Cossu, A, additional, Palumbo, D, additional, De Pascale, S, additional, Gualtierotti, M, additional, Vecchiato, M, additional, Parise, P, additional, Puccetti, F, additional, Barbieri, L, additional, Elmore, U, additional, De Cobelli, F, additional, Fumagalli Romario, U, additional, Ferrari, G, additional, Petri, R, additional, and Rosati, R, additional

Published
2022
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12. Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

Author

Kroese, T.E. van Hillegersberg, R. Schoppmann, S. Deseyne, P.R.A.J. Nafteux, P. Obermannova, R. Nordsmark, M. Pfeiffer, P. Hawkings, M.A. Smyth, E. Markar, S. Hanna, G.B. Cheong, E. Chaudry, A. Elme, A. Adenis, A. Piessen, G. Gani, C. Bruns, C.J. Moehler, M. Liakakos, T. Reynolds, J. Morganti, A. Rosati, R. Castoro, C. D'Ugo, D. Roviello, F. Bencivenga, M. de Manzoni, G. Jeene, P. van Sandick, J.W. Muijs, C. Slingerland, M. Nieuwenhuijzen, G. Wijnhoven, B. Beerepoot, L.V. Kolodziejczyk, P. Polkowski, W.P. Alsina, M. Pera, M. Kanonnikoff, T.F. Nilsson, M. Guckenberger, M. Monig, S. Wagner, D. Wyrwicz, L. Berbee, M. Gockel, I. Lordick, F. Griffiths, E.A. Verheij, M. van Rossum, P.S.N. van Laarhoven, H.W.M. Rosman, C. Rütten, H. Gootjes, E.C. Vonken, F.E.M. van Dieren, J.M. Vollebergh, M.A. van der Sangen, M. Creemers, G.-J. Zander, T. Schlößer, H. Cascinu, S. Mazza, E. Nicoletti, R. Damascelli, A. Slim, N. Passoni, P. Cossu, A. Puccetti, F. Barbieri, L. Fanti, L. Azzolini, F. Ventoruzzo, F. Szczepanik, A. Visa, L. Reig, A. Roques, T. Harrison, M. Ciseł, B. Pikuła, A. Skórzewska, M. Vanommeslaeghe, H. Van Daele, E. Pattyn, P. Geboes, K. Callebout, E. Ribeiro, S. van Duijvendijk, P. Tromp, C. Sosef, M. Warmerdam, F. Heisterkamp, J. Vera, A. Jordá, E. López-Mozos, F. Fernandez-Moreno, M.C. Barrios-Carvajal, M. Huerta, M. de Steur, W. Lips, I. Diez, M. Castro, S. O'Neill, R. Holyoake, D. Hacker, U. Denecke, T. Kuhnt, T. Hoffmeister, A. Kluge, R. Bostel, T. Grimminger, P. Jedlička, V. Křístek, J. Pospíšil, P. Mourregot, A. Maurin, C. Starling, N. Chong, I. OMEC working group

Abstract

Background: Consensus about the definition and treatment of oligometastatic oesophagogastric cancer is lacking. Objective: To assess the definition and treatment of oligometastatic oesophagogastric cancer across multidisciplinary tumour boards (MDTs) in Europe. Material and methods: European expert centers (n = 49) were requested to discuss 15 real-life cases in their MDT with at least a medical, surgical, and radiation oncologist present. The cases varied in terms of location and number of metastases, histology, timing of detection (i.e. synchronous versus metachronous), primary tumour treatment status, and response to systemic therapy. The primary outcome was the agreement in the definition of oligometastatic disease at diagnosis and after systemic therapy. The secondary outcome was the agreement in treatment strategies. Treatment strategies for oligometastatic disease were categorised into upfront local treatment (i.e. metastasectomy or stereotactic radiotherapy), systemic therapy followed by restaging to consider local treatment or systemic therapy alone. The agreement across MDTs was scored to be either absent/poor (

Published
2022

13. Evaluation of International Contemporary Operative Outcomes and Management Trends Associated With Esophagectomy: A 4-Year Study of6000 Patients Using ECCG Definitions and the Online Esodata Database

Author

Kuppusamy, Madhan K, Low, Donald E, Rosati R, Puccetti F, Kuppusamy, Madhan K, Low, Donald, E, Rosati, R, Puccetti, F, and Surgery

Subjects
Adult, Male, Internationality, Time Factors, complications, Databases, Factual, Esophageal Neoplasms, medicine.medical_treatment, MEDLINE, Anastomosis, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Invasive esophagectomy, medicine, Humans, In patient, Prospective Studies, Aged, surgical and quality outcomes measures, Aged, 80 and over, Internet, Database, business.industry, Esodata online oncologic database, Middle Aged, Esophagectomy, Benchmarking, Treatment Outcome, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, Observational study, Female, Complication, business, computer, Neoadjuvant chemoradiotherapy
Abstract

This study aims to verify the utility of international online datasets to benchmark and monitor treatment and outcomes in major oncologic procedures. Objective:This study aims to verify the utility of international online datasets to benchmark and monitor treatment and outcomes in major oncologic procedures.Background:The Esophageal Complication Consensus Group (ECCG) has standardized the reporting of complications after esophagectomy within the web-based Esodata.org database. This study will utilize the Esodata dataset to update contemporary outcomes and to monitor trends in practice in an era of rapid technical change.Methods:This observational study, based on a prospectively developed specific database, updates esophagectomy outcomes collected between 2015 and 2018. Evolution in patient and operative demographics, treatment, complications, and quality outcome measures were compared between patients undergoing surgery in 2015 to 2016 and 2017 to 2018.Results:Between 2015 and 2018, 6022 esophagectomies from 39 centers were entered into Esodata. Most patients were male (78.3%) with median age 63. Patients having minimally invasive esophagectomy constituted 3177 (52.8%), a chest anastomosis 3838 (63.7%), neoadjuvant chemoradiotherapy 2834 (48.7%), and R0 resections 5441 (93.5%). For quality measures, 30- and 90-day mortality was 2.0% and 4.5%, readmissions 9.7%, transfusions 12%, escalation in care 22.1%, and discharge home 89.4%. Trends in quality measures between 2015 and 2016 (2407 patients) and 2017 and 2018 (3318 patients) demonstrated significant (P < 0.05) improvements in readmissions 11.1% to 8.5%, blood transfusions 14.3% to 10.2%, and escalation in care from 24.5% to 20% A significantly (P < 0.05) reduced incidence in pneumonia (15.3%-12.8%) and renal failure (1.0%-0.4%) was observed. Anastomotic leak rates increased from 11.7% to 13.1%, whereas leaks requiring surgery decreased 3.3% and 3.0%, respectively.Conclusions:The Esodata database provides a valuable resource for assessing contemporary international outcomes. This study highlights an increased application of minimally invasive approaches, a high percentage of complications, improvements in pneumonia and key quality metrics, but with anastomotic leak rates still >10%.

Published
2020

17. Neoadjuvant chemoradiotherapy in patients with esopageal or esophageal gastric junction cancer

Author

Slim N., Tummineri R., Parise P., Mazza E., Albarello L., Puccetti F., Deli A. M., Incerti E., Azizi M., Dell'oca I., Cossu A., Reni M., Rosati R., Passoni P., Di Muzio N., Slim, N., Tummineri, R., Parise, P., Mazza, E., Albarello, L., Puccetti, F., Deli, A. M., Incerti, E., Azizi, M., Dell'Oca, I., Cossu, A., Reni, M., Rosati, R., Passoni, P., and Di Muzio, N.

Published
2019

20. EP-1434 Neoadjuvant chemoradiotherapy in patients with esopageal or esophageal gastric junction cancer

Author

Slim, N., primary, Tummineri, R., additional, Parise, P., additional, Mazza, E., additional, Albarello, L., additional, Puccetti, F., additional, Deli, A.M., additional, Incerti, E., additional, Azizi, M., additional, Dell'oca, I., additional, Cossu, A., additional, Reni, M., additional, Rosati, R., additional, Passoni, P., additional, and Di Muzio, N., additional

Published
2019
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26. A comparison of the left thoracoabdominal and Ivor–Lewis esophagectomy

Author

Davies, A R, primary, Zylstra, J, additional, Baker, C R, additional, Gossage, J A, additional, Dellaportas, D, additional, Lagergren, J, additional, Findlay, J M, additional, Puccetti, F, additional, El Lakis, M, additional, Drummond, R J, additional, Dutta, S, additional, Mera, A, additional, Van Hemelrijck, M, additional, Forshaw, M J, additional, Maynard, N D, additional, Allum, W H, additional, Low, D, additional, and Mason, R C, additional

Published
2017
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30. A comparison of the left thoracoabdominal and Ivor-Lewis esophagectomy.

Author

Davies, A. R., Zylstra, J., Baker, C. R., Gossage, J. A., Dellaportas, D., Lagergren, J., Findlay, J. M., Puccetti, F., Lakis, M. El, Drummond, R. J., Dutta, S., Mera, A., Van Hemelrijck, M., Forshaw, M. J., Maynard, N. D., Allum, W. H., Low, D., and Mason, R. C.

Subjects
ESOPHAGECTOMY, HEALTH outcome assessment, CONFIDENCE intervals, ADENOCARCINOMA, LYMPH nodes
Abstract

The purpose of this study was to assess the oncological outcomes of a large multicenter series of left thoracoabdominal esophagectomies, and compare these to the more widely utilized Ivor-Lewis esophagectomy. With ethics approval and an established study protocol, anonymized data from five centers were merged into a structured database. The study exposure was operative approach (ILE or LTE). The primary outcome measure was time to death. Secondary outcome measures included time to tumor recurrence, positive surgical resection margins, lymph node yield, postoperative death and hospital length of stay. Cox proportional hazards models provided hazard ratios (HR) with 95% confidence intervals (CI) adjusting for age, pathological tumor stage, tumor grade, lymphovascular invasion and neoadjuvant treatment. Among 1228 patients (598 ILE; 630 LTE), most (86%) had adenocarcinoma (AC) and were male (81%). Comparing ILE and LTE for AC patients, no difference was seen in terms of time to death (HR 0.904 95%CI 0.749-1.1090) or time to recurrence (HR 0.973 95%CI 0.768-1.232). The risk of a positive resection margin was also similar (OR 1.022 95%CI 0.731-1.429). Median lymph node yield did not differ between approaches (LTE 21; ILE 21; P = 0.426). In-hospital mortality was 2.4%, significantly lower in the LTE group (LTE 1.3%; ILE 3.6%; P = 0.004). Median hospital stay was 11 days in the LTE group and 14 days in the ILE group (P < 0.0001). In conclusion, this is the largest series of left thoracoabdominal esophagectomies to be submitted for publication and the only one to compare two different transthoracic esophagectomy strategies. It demonstrates oncological equivalence between operative approaches but possible short- term advantages to the left thoracoabdominal esophagectomy. [ABSTRACT FROM AUTHOR]

Published
2018
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35. Potassium, Rubidium, Caesium and Digitalis Intoxication

Author

Rubegni M, Sandro Forconi, T. Di Perri, and Puccetti F

Subjects
chemistry, business.industry, Caesium, Potassium, Radiochemistry, chemistry.chemical_element, Medicine, Pharmacology (medical), DIGITALIS INTOXICATION, Cardiology and Cardiovascular Medicine, business, Rubidium
Published
1966
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36. Contents, Vol. 49, 1966

Author

P. Lindgren, N.S. Dhalla, E. Helander, E.K. Adrian, J.W. Manning, Sandro Forconi, Rubegni M, T. Di Perri, Puccetti F, and B.E. Walker

Subjects
Traditional medicine, business.industry, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business
Published
1966
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37. Effects of Prostaglandin A1on Renal Handling of Salt and Water in Congestive Heart Failure

Author

Perri, T. Di, Forconi, S., Puccetti, F., Vittoria, A., and Guerrini, M.

Abstract

Prostaglandin A1(PGA1) was infused at the rate of 1/μg/kg/min in 10 patients with decompensated heart failure under conditions of water loading (5 patients) or water deprivation (5 patients). During water loading, PGA1increased urinary excretion of sodium, potassium, chloride, calcium, and magnesium, as well as free-water clearance. During water deprivation, it increased free-water reabsorption. Glomerular filtration rate was increased slightly by PGA1only when it was given with an infusion of hypertonic mannitol during water deprivation. This selective action of PGA1, which increased the excretion but not the reabsorption of free water, suggests its use to correct certain hypo-osmolar conditions. The site of action of PGA1on the kidney seems to be in the tubules and mainly in the proximal tubules. These findings might be important in the understanding of the role of renal prostaglandins.

Published
1980

40. Index nominum ad Vol. XLIX

Author

E. Helander, B.E. Walker, J.W. Manning, N.S. Dhalla, Puccetti F, T. Di Perri, P. Lindgren, E.K. Adrian, Sandro Forconi, and Rubegni M

Subjects
business.industry, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business, Humanities
Published
1966
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41. ERAS guidelines-driven upper gastrointestinal contrast study after esophagectomy

Author

Francesco Puccetti, Donald E. Low, MadhanKumar Kuppusamy, Fredrik Klevebro, Michal Hubka, Puccetti, F., Klevebro, F., Kuppusamy, M. K., Hubka, M., and Low, D. E.

Subjects
medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Anastomosis, Postoperative Complications, Internal medicine, Delayed Gastric emptying, medicine, Humans, Ivor lewis, Upper gastrointestinal, ERAS, Retrospective Studies, business.industry, Gastric conduit, Anastomosis, Surgical, Hepatology, Surgery, Esophagectomy, Jejunostomy, Enhanced Recovery After Surgery, business, Abdominal surgery
Abstract

Background: Early nasogastric tube (NGT) removal is a component of enhanced recovery after surgery (ERAS) protocol for esophagectomy. The aim of this study is to assess a protocol-driven application of UGI contrast study to facilitate early NGT removal and direct a standardized therapeutic response in patients with evidence for delayed gastric conduit emptying (DGCE). Methods: All patients undergoing esophagectomy between January 2017 and October 2019 were prospectively enrolled. Esophageal resections were performed through different surgical approaches involving gastric conduit reconstruction. A standardized clinical protocol (SCP) was systematically applied, which targeted a UGI contrast study on POD 2–3 to allow immediate NGT removal or initiate DGCE protocols. Results: This study enrolled 50 patients undergoing open Ivor Lewis (42%), left thoracoabdominal (46%), and three-field procedure (12%) with gastric conduit reconstruction and either upper thoracic (66%) or cervical (34%) anastomosis. Jejunostomy was routinely placed while pyloric procedures were not performed. Patients achieving targeted contrast study (86%) demonstrated significantly earlier NGT removal (p-value 0.010), oral protocol initiation (0.001), and decreased length of hospital stay (6 vs 10days, 0.024). Four patients (8%) presented with radiology signs of DCGE and underwent protocoled treatment, eventually achieving discharge similar to the overall study population (7 vs 8.5days). Conclusions: Protocol-driven UGI contrast study can effectively provide objective data facilitating early NGT removal and discharge. Patients with DGCE can successfully undergo intervention to improve conduit emptying and adhere to ERAS discharge goals.

Published
2021
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42. Treatment of Epiphrenic Diverticulum: How I Do It

Author

Riccardo Rosati, Francesco Puccetti, Ugo Elmore, Lavinia Barbieri, Paolo Parise, Andrea Cossu, Eider Talavera Urquijo, Barbieri, L. A., Parise, P., Cossu, A., Puccetti, F., Elmore, U., Talavera Urquijo, E., and Rosati, R.

Subjects
Male, medicine.medical_specialty, Fundoplication, Achalasia, Esophageal Disorder, digestive system, 03 medical and health sciences, 0302 clinical medicine, Submucosa, otorhinolaryngologic diseases, medicine, Epiphrenic diverticulum, Humans, minimally invasive surgery, minimally invasive myotomy, esophageal motility disorders, business.industry, Stomach, diverticulectomy, medicine.disease, digestive system diseases, Surgery, achalasia, surgical procedures, operative, medicine.anatomical_structure, Thoracotomy, Esophageal motility disorder, epiphrenic diverticulum, Esophagoplasty, 030220 oncology & carcinogenesis, Diverticulum, Esophageal, Female, Laparoscopy, 030211 gastroenterology & hepatology, business, Myotomy
Abstract

Epiphrenic diverticulum is a rare esophageal disorder occurring as an outpouching of mucosa and submucosa through the muscular layers, within 10 cm above the cardia. As the majority of epiphrenic diverticula are asymptomatic, the real incidence varies because of a considerable number of cases detected incidentally during radiographic or endoscopic evaluation. Traditionally, the operation was performed through a left thoracotomy approach and the diverticulectomy was completed with esophago-cardial myotomy and a Belsey Mark IV fundoplication. Laparoscopy offers many advantages in the treatment such as the possibility of extension of the myotomy from the lower esophagus through the stomach and the concomitant antireflux procedure to avoid postoperative reflux. The abdominal approach is also more comfortable for the patients and, as there is no need for transthoracic drains, is more tolerated in terms of postoperative pain. In this article, we do review our technique with all the steps of the operation illustrated by intraoperative pictures.

Published
2020
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43. Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

Author

Tiuri E. Kroese, Richard van Hillegersberg, Sebastian Schoppmann, Pieter R.A.J. Deseyne, Philippe Nafteux, Radka Obermannova, Marianne Nordsmark, Per Pfeiffer, Maria A. Hawkins, Elizabeth Smyth, Sheraz Markar, George B. Hanna, Edward Cheong, Asif Chaudry, Anneli Elme, Antoine Adenis, Guillaume Piessen, Cihan Gani, Christiane J. Bruns, Markus Moehler, Theodore Liakakos, John Reynolds, Alessio Morganti, Riccardo Rosati, Carlo Castoro, Domenico D'Ugo, Franco Roviello, Maria Bencivenga, Giovanni de Manzoni, Paul Jeene, Johanna W. van Sandick, Christel Muijs, Marije Slingerland, Grard Nieuwenhuijzen, Bas Wijnhoven, Laurens V. Beerepoot, Piotr Kolodziejczyk, Wojciech P. Polkowski, Maria Alsina, Manuel Pera, Tania F. Kanonnikoff, Magnus Nilsson, Matthias Guckenberger, Stefan Monig, Dorethea Wagner, Lucjan Wyrwicz, Maaike Berbee, Ines Gockel, Florian Lordick, Ewen A. Griffiths, Marcel Verheij, Peter S.N. van Rossum, Hanneke W.M. van Laarhoven, Camiel Rosman, Heide Rütten, Elske C. Gootjes, Francine E.M. Vonken, Jolanda M. van Dieren, Marieke A. Vollebergh, Maurice van der Sangen, Geert-Jan Creemers, Thomas Zander, Hans Schlößer, Stefano Cascinu, Elena Mazza, Roberto Nicoletti, Anna Damascelli, Najla Slim, Paolo Passoni, Andrea Cossu, Francesco Puccetti, Lavinia Barbieri, Lorella Fanti, Francesco Azzolini, Federico Ventoruzzo, Antoni Szczepanik, Laura Visa, Anna Reig, Tom Roques, Mark Harrison, Bogumiła Ciseł, Agnieszka Pikuła, Magdalena Skórzewska, Hanne Vanommeslaeghe, Elke Van Daele, Piet Pattyn, Karen Geboes, Eduard Callebout, Suzane Ribeiro, Peter van Duijvendijk, Cathrien Tromp, Meindert Sosef, Fabienne Warmerdam, Joos Heisterkamp, Almudena Vera, Esther Jordá, Fernando López-Mozos, Maria C. Fernandez-Moreno, Maria Barrios-Carvajal, Marisol Huerta, Wobbe de Steur, Irene Lips, Marc Diez, Sandra Castro, Robert O'Neill, Daniel Holyoake, Ulrich Hacker, Timm Denecke, Thomas Kuhnt, Albrecht Hoffmeister, Regine Kluge, Tilman Bostel, Peter Grimminger, Václav Jedlička, Jan Křístek, Petr Pospíšil, Anne Mourregot, Clotilde Maurin, Naureen Starling, Irene Chong, Institut Català de la Salut, [Kroese TE] Department of Surgery, Utrecht University Medical Center, Utrecht University, Utrecht, the Netherlands. Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. [van Hillegersberg R] Department of Surgery, Utrecht University Medical Center, Utrecht University, Utrecht, the Netherlands. [Schoppmann S] Department of Surgery, Medical University of Vienna, Vienna University, Vienna, Austria. [Deseyne PRAJ] Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium. [Nafteux P] Department of Surgery, KU Leuven, Leuven University, Leuven, Belgium. [Obermannova R] Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic. [Alsina M] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Radiotherapie, MUMC+: MA Radiotherapie OC (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Radiation Oncology, AII - Cancer immunology, CCA - Cancer biology and immunology, Internal medicine, Surgery, Kroese, T. E., van Hillegersberg, R., Schoppmann, S., Deseyne, P. R. A. J., Nafteux, P., Obermannova, R., Nordsmark, M., Pfeiffer, P., Hawkings, M. A., Smyth, E., Markar, S., Hanna, G. B., Cheong, E., Chaudry, A., Elme, A., Adenis, A., Piessen, G., Gani, C., Bruns, C. J., Moehler, M., Liakakos, T., Reynolds, J., Morganti, A., Rosati, R., Castoro, C., D'Ugo, D., Roviello, F., Bencivenga, M., de Manzoni, G., Jeene, P., van Sandick, J. W., Muijs, C., Slingerland, M., Nieuwenhuijzen, G., Wijnhoven, B., Beerepoot, L. V., Kolodziejczyk, P., Polkowski, W. P., Alsina, M., Pera, M., Kanonnikoff, T. F., Nilsson, M., Guckenberger, M., Monig, S., Wagner, D., Wyrwicz, L., Berbee, M., Gockel, I., Lordick, F., Griffiths, E. A., Verheij, M., van Rossum, P. S. N., van Laarhoven, H. W. M., Rosman, C., Rutten, H., Gootjes, E. C., Vonken, F. E. M., van Dieren, J. M., Vollebergh, M. A., van der Sangen, M., Creemers, G. -J., Zander, T., Schlosser, H., Cascinu, S., Mazza, E., Nicoletti, R., Damascelli, A., Slim, N., Passoni, P., Cossu, A., Puccetti, F., Barbieri, L., Fanti, L., Azzolini, F., Ventoruzzo, F., Szczepanik, A., Visa, L., Reig, A., Roques, T., Harrison, M., Cisel, B., Pikula, A., Skorzewska, M., Vanommeslaeghe, H., Van Daele, E., Pattyn, P., Geboes, K., Callebout, E., Ribeiro, S., van Duijvendijk, P., Tromp, C., Sosef, M., Warmerdam, F., Heisterkamp, J., Vera, A., Jorda, E., Lopez-Mozos, F., Fernandez-Moreno, M. C., Barrios-Carvajal, M., Huerta, M., de Steur, W., Lips, I., Diez, M., Castro, S., O'Neill, R., Holyoake, D., Hacker, U., Denecke, T., Kuhnt, T., Hoffmeister, A., Kluge, R., Bostel, T., Grimminger, P., Jedlicka, V., Kristek, J., Pospisil, P., Mourregot, A., Maurin, C., Starling, N., Chong, I., Oncology, CCA - Imaging and biomarkers, CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Cancer Research, neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias gástricas [ENFERMEDADES], Neoplasm metastasis, Radiosurgery, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], SDG 3 - Good Health and Well-being, Metàstasi, Neoplasms, Medicine and Health Sciences, Humans, Mastectomia, Oligometastasis, SURGICAL RESECTION, Metastasectomy, Neoplasms::Neoplastic Processes::Neoplasm Metastasis [DISEASES], Aparell digestiu - Càncer - Cirurgia, CHEMOTHERAPY, Europe, Surgical Procedures, Operative::Metastasectomy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], intervenciones quirúrgicas::metastasectomía [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Oncology, neoplasias::procesos neoplásicos::metástasis neoplásica [ENFERMEDADES], JUNCTION, Gastric neoplasm, SURVIVAL, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Stomach Neoplasms [DISEASES], Lymph Nodes, Oesophageal neoplasm
Abstract

Oesophageal neoplasm; Oligometastasis; Radiosurgery Neoplàsia esofàgica; Oligometàstasi; Radiocirurgia Neoplasia esofágica; Oligometástasis; Radiocirugía Background Consensus about the definition and treatment of oligometastatic oesophagogastric cancer is lacking. Objective To assess the definition and treatment of oligometastatic oesophagogastric cancer across multidisciplinary tumour boards (MDTs) in Europe. Material and methods European expert centers (n = 49) were requested to discuss 15 real-life cases in their MDT with at least a medical, surgical, and radiation oncologist present. The cases varied in terms of location and number of metastases, histology, timing of detection (i.e. synchronous versus metachronous), primary tumour treatment status, and response to systemic therapy. The primary outcome was the agreement in the definition of oligometastatic disease at diagnosis and after systemic therapy. The secondary outcome was the agreement in treatment strategies. Treatment strategies for oligometastatic disease were categorised into upfront local treatment (i.e. metastasectomy or stereotactic radiotherapy), systemic therapy followed by restaging to consider local treatment or systemic therapy alone. The agreement across MDTs was scored to be either absent/poor (

Published
2022
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44. Impact of standardized clinical pathways on esophagectomy: a systematic review and meta-analysis

Author

Donald E. Low, MadhanKumar Kuppusamy, Francesco Puccetti, Michal Hubka, Bas P. L. Wijnhoven, Surgery, Puccetti, F., Wijnhoven, B. P. L., Kuppusamy, M., Hubka, M., and Low, D. E.

Subjects
medicine.medical_specialty, Complications, medicine.medical_treatment, MEDLINE, 030230 surgery, law.invention, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Clinical pathway, Randomized controlled trial, law, medicine, Humans, Prospective Studies, Retrospective Studies, business.industry, Gastroenterology, General Medicine, Odds ratio, Length of Stay, Jadad scale, Esophagectomy, Systematic review, 030220 oncology & carcinogenesis, Meta-analysis, Emergency medicine, Critical Pathways, business, Esophageal cancers
Abstract

Summary Esophageal surgery is historically associated with adverse postoperative outcomes. Selected high-volume centers have previously reported the effect on clinical outcomes following the adoption of a standardized clinical pathway (SCP). This meta-analysis aims to evaluate the current literature to document the effect of SCP and enhanced recovery after surgery (ERAS) on esophagectomy outcomes. A literature search was conducted through the main search engines (PubMed, Embase, Medline, and Cochrane database) in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. All eligible comparative studies (randomized control trial, prospective, retrospective, and combined) were identified and assessed based on Methodological Index for Non-Randomized Studies and Jadad quality criteria. Data concerning overall morbidity, early mortality, and length of stay (LOS) were primarily collected and compared. Secondary outcomes included anastomotic leaks, pulmonary complications, and readmission rate. Twenty-six articles (including five randomized controlled trials and six prospective trials) were included in the analysis. Overall study quality was moderate and the included studies utilized a variable approach to SCP. No statistically significant differences were found between groups in terms of overall morbidity, postoperative mortality, anastomotic leak, and readmission rates. Significant improvements included pulmonary complications (odds ratios [OR] 0.66, 95% confidence interval [CI] 0.49–0.94) and hospital LOS (OR −3.68, 95% CI −4.49 to −2.87). Previous reports of SCP within esophagectomy programs have demonstrated clinical improvements in postoperative pulmonary complications and LOS. Given the high heterogeneity historically demonstrated within SCPs, further improvement in outcomes should be expected following the adoption of standardized ERAS guidelines.

Published
2021
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45. Long-term variation in skeletal muscle and adiposity in patients undergoing esophagectomy

Author

Wesley Jenq, Piers R. Boshier, Keerthini Muthuswamy, George B. Hanna, Donald E. Low, Fredrik Klevebro, Francesco Puccetti, Boshier, P. R., Klevebro, F., Jenq, W., Puccetti, F., Muthuswamy, K., Hanna, G. B., and Low, D. E.

Subjects
medicine.medical_specialty, Sarcopenia, Multivariate analysis, medicine.medical_treatment, Urology, sarcopenia, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, In patient, skeletal muscle, Muscle, Skeletal, Neoadjuvant therapy, Retrospective Studies, AcademicSubjects/MED00260, body composition, adiposity, business.industry, Gastroenterology, Cancer, Skeletal muscle, General Medicine, Esophageal cancer, medicine.disease, Prognosis, Esophagectomy, medicine.anatomical_structure, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Original Article, business
Abstract

Summary This study seeks to define long-term variation in body composition in patients undergoing esophagectomy for cancer and to associate those changes with survival. Assessment of skeletal muscle, visceral (VAT) and subcutaneous adipose tissue (SAT) was performed using computed tomography (CT) images routinely acquired: at diagnosis; after neoadjuvant therapy, and; >6 months after esophagectomy. In cases where multiple CT scans were performed >6 months after surgery, all available images were assessed. Ninty-seven patients met inclusion criteria with a median of 2 (range 1–10) postoperative CT images acquired between 0.5 and 9.7 years after surgery. Following surgical treatment of esophageal cancer, patients lost on average 13.3% of their skeletal muscle, 64.5% of their VAT and 44.2% of their SAT. Sarcopenia at diagnosis was not associated with worse overall survival (66.3% vs. 68.5%; P = 0.331). Sarcopenia 1 year after esophagectomy was however associated with lower 5-year overall survival (53.8% vs. 87.5%; P = 0.019). Survival was lower in those patients who had >10% decrease in skeletal muscle index (SMI; 33.3% vs. 72.1%; P = 0.003) and >40% decrease in SAT 1 year after surgery (40.4% vs. 67.4%; P = 0.015). On multivariate analysis, a decline in SMI 1 year after surgery was predictive of worse survival (HR 0.38, 95%CI 0.20–0.73; P = 0.004). This study provides new insight relating to long-term variation in body composition in patients undergoing esophagectomy for cancer. Findings provide further evidence of the importance of body composition, in particular depletion of skeletal muscle, in predicting survival following esophagectomy.

Published
2020

46. Peroral endoscopic myotomy versus surgical myotomy for primary achalasia: single-center, retrospective analysis of 74 patients

Author

Riccardo Rosati, Francesco Puccetti, Uberto Fumagalli, S. de Pascale, Elisa Carlani, Alessandro Repici, De Pascale, S., Repici, A., Puccetti, F., Carlani, E., Rosati, Riccardo, and Fumagalli, U.

Subjects
Myotomy, medicine.medical_specialty, medicine.medical_treatment, Achalasia, foregut surgery, 03 medical and health sciences, 0302 clinical medicine, medicine, Esophagus, esophagogastric junction, business.industry, surgical endoscopy, Gastroenterology, Reflux, General Medicine, Perioperative, medicine.disease, laparoscopic surgery, Dysphagia, Surgery, medicine.anatomical_structure, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, esophageal achalasia, medicine.symptom, Surgical endoscopy, business, Esophagitis, antireflux surgery
Abstract

Achalasia is a neurodegenerative motility disorder of the esophagus; dysphagia, weight loss, chest pain, and regurgitation are its main symptoms. Surgical myotomy (HM) is considered the gold standard treatment. However, peroral endoscopic myotomy (POEM) seems to be a safe and effective alternative option. The aim of this study is to compare the safety and efficacy of these techniques. From March 2012 to June 2015, 74 patients with symptomatic primary achalasia underwent myotomy. The two groups were compared in terms of intraoperative and postoperative outcomes and Eckardt score at last follow-up. A morphofunctional comparison was also performed. Thirty-two myotomies were performed endoscopically (POEM group) and 42 were performed laparoscopically with a 180° anterior fundoplication (surgical myotomy [SM] group). Operative time was significantly shorter for the POEM group (63 [range: 32–114] vs. 76 minutes [54–152]; P = 0.0005). Myotomy was significantly longer for the POEM group (12 [range: 10–15] vs. 9 cm [range: 7–10]; P = 0.0001). Postoperative morbidity occurred in two patients (4.7%) in the SM group; no complications (P = not significant) were recorded for the POEM group. The median Eckardt score at last follow-up decreased for each group from 6 to 1 (P < 0.001). Morphological evaluation was performed for 20 patients and functional evaluation was performed in 18 patients of each group. Lower esophageal sphincter resting and relaxation pressures were significantly reduced in both groups (P < 0.001). Eight patients in the POEM group (40%) had esophagitis at endoscopy: 4 (20%) with Los Angeles (LA) grade A, 3 (15%) with LA grade B, and 1 patient with LA grade D (5%). Five patients in POEM group (28%) had a pathologic DeMeester score. In the SM group, one patient (5%) had esophagitis (P = 0.04; 95% CI) and 4 patients (22%) presented a pathological DeMeester score. Perioperative results for POEM and SM are similar. The absence of an antireflux wrap leads to an increased risk of reflux with consequent esophagitis. SM with an antireflux wrap could be a preferred choice when a long standing gastroesophageal reflux could potentially lead to a damage as, for example, in young patients.

Published
2017
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47. Current approaches to clinical research with respect to esophageal resection: are online clinical datasets the future?

Author

Francesco Puccetti, Donald E. Low, Michal Hubka, Madhan Kumar Kuppusamy, Puccetti, F., Kuppusamy, M. K., Hubka, M., and Low, D. E.

Subjects
medicine.medical_specialty, business.industry, Hospital high-volume, Gastroenterology, Resection, Esophagectomy, Clinical research, Outcome assessment health care, medicine, Surgery, Medical physics, Current (fluid), business, Database management systems
Abstract

The use of large data systems or databases has always played a major role in clinical research. These datasets have been based in individual institutions as well as national, international, and professional society registries. Although valuable resources, these databases all have limitations including: biased patient selection, variable institutional involvement and failure to update database components over time. Potentially, the single greatest drawback to many national datasets is the fact that they were not designed to specifically address clinical research projects. This has motivated certain clinical groups to develop "made for purpose" datasets. An example of this type of dataset was developed in 2015 by the Esophageal Complications Consensus Group (ECCG) who produced a standardized online platform including pre-established definitions and quality parameters for assessing perioperative outcomes associated with esophageal resection. This online clinical database (Esodata.org) is a unique resource, designed with a secure and standardized web-based interface and consensus-based data fields and analysis. In 2017, utilizing data from Esodata.org, the ECCG published the first benchmark for perioperative outcomes and complications associated with esophagectomy. This was achieved by the collaboration of 24 high-volume centers, gathering targeted data on 2,704 esophageal resections between 2015 and 2016. The number of high-volume member institutions has now increased to 40 international participants from 19 individual countries, which has created the opportunity to exponentially increase numbers within the dataset but, also, increase the international relevance of the clinical research. The Esodata database now provides a reliable vehicle for monitoring longitudinal, technical and clinical benchmarks, in a period of rapid technical and process changes associated with esophageal resection.

Published
2020
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48. Endoscopic management of Zenker’s diverticulum: stapling vs. Z-POEM

Author

Paolo Parise, Riccardo Rosati, Marco Palucci, Lorenzo Cinelli, Lavinia Barbieri, Francesco Puccetti, Greta Olivari, Andrea Cossu, Raffaele Cerchione, Cerchione, R., Parise, P., Olivari, G., Cossu, A., Barbieri, L., Palucci, M., Cinelli, L., Puccetti, F., and Rosati, R.

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Zenker’s diverticulum (ZD), business.industry, General surgery, Endoscopic management, medicine.disease, Flexible endoscopy, Zenker's diverticulum, Endoscopic stapling diverticulostomy, Stapling diverticulostomy, medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Per-oral-endoscopic-myotomy for Zenker’s diverticulum (Z-POEM)
Abstract

Zenker’s diverticulum (ZD) is a rare disease of the elderly. Surgery was the first treatment option for many years. Subsequently many different endoscopic treatments have been introduced in order to reduce the complication rate. Endoscopic stapled diverticulostomy (ESD) is a well-known procedure since 1993. Recently an endoscopic myotomy of the upper esophageal sphincter (UES), called per-oral-endoscopic-myotomy for Zenker’s diverticulum (Z-POEM) and derived from the POEM technique for achalasia, has been proposed. The aim of this study is to describe and compare these two different techniques for treatment of ZD in order to assess their efficacy and safety. We reviewed literature of the last 10 years on 1,490 patients that underwent ESD from 11 different papers and on 96 patients from 9 papers that underwent Z-POEM. Surgical procedure techniques, clinical and technical success, recurrence rate and complications were reviewed. The most common complications are bleeding and perforations that most of time are self-resolving but sometimes could require a surgical intervention. Other minor but frequent complications are dental avulsions and lips tears. Only one death was described among those submitted to ESD. Both procedures are effective in symptoms solutions with a low recurrence rate. Anyway, the main drawback of ESD is the difficult positioning of the diverticuloscope, that is the main reason for technical failure. On the opposite data about Z-POEM are few and of low quality, so some concerns remain about symptoms such regurgitation and aspiration. Minimally invasive treatment of ZD with both ESD and Z-POEM is a valuable option for this disorder. They are both safe, feasible and effective, in terms of hospital stay, complication rate and clinical success rate. Long-term results have to be evaluated considering a larger population for the Z-POEM procedure.

Published
2020
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49. Early distribution, clinical benefits, and limits of the implementation of the standardized clinical pathway following esophagectomy

Author

Francesco Puccetti, Donald E. Low, Madhan Kumar Kuppusamy, Michal Hubka, Puccetti, F., Kuppusamy, M. K., Hubka, M., and Low, D. E.

Subjects
Oncology, medicine.medical_specialty, business.industry, medicine.medical_treatment, Gastroenterology, Evidence-based practice, Esophagectomy, Clinical pathway, Internal medicine, medicine, Distribution (pharmacology), Surgery, business, Critical pathways, Enhanced recovery
Abstract

While historically associated with significant postoperative morbidity and mortality rates, esophagectomy remains a major component of the multimodality treatment for esophageal cancer. Over time, multiple advances have led to an improvement in clinical and oncological outcomes after surgery. Similar to the results demonstrated with the enhanced recovery after surgery (ERAS) protocols, standardized clinical pathways (SCPs) represent an infrastructure to provide patients with improved clinical outcomes. The aim of this report is to analyze the global application of SCPs and evaluate its effect on outcomes and to assess current levels of adoption in high volume centers. A literature review was conducted through the main search engines (PubMed, Embase, Medline and Cochrane database) to identify eligible comparative studies. All data concerning overall morbidity, length of stay (LOS), and postoperative mortality were collected and statistically analyzed. The search yielded 26 articles (among which five RCTs and six prospective trials) reporting on SCPs but focusing on different perioperative outcomes. Postoperative outcomes improved after the application of SCP, including overall morbidity (29.8% vs. 32.5%, P=0.350), and LOS (9.9±2.8 vs. 13.4±1.0, P

Published
2020
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50. Reply to letter: obesity and esophagectomy for esophageal cancer: is it only the high BMI that defines prognosis?

Author

O Mc Cormack, William H. Allum, V Mengardo, F Pucetti, Asif Chaudry, Mc Cormack, O., Mengardo, V., Puccetti, F., Chaudry, A., and Allum, W. H.

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Esophageal cancer, MEDLINE, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Text mining, Internal medicine, Humans, Medicine, Obesity, Body mass index, 030109 nutrition & dietetics, business.industry, Gastroenterology, General Medicine, Prognosis, medicine.disease, Esophagectomy, 030220 oncology & carcinogenesis, business
Published
2018
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