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25 results on '"Pu, Xiangdong"'

4. Crocus genome reveals the evolutionary origin of crocin biosynthesis

Author

Xu, Zhichao, primary, Chen, Shanshan, additional, Wang, Yalin, additional, Tian, Ya, additional, Wang, Xiaotong, additional, Xin, Tianyi, additional, Li, Zishan, additional, Hua, Xin, additional, Tan, Shengnan, additional, Sun, Wei, additional, Pu, Xiangdong, additional, Yao, Hui, additional, Gao, Ranran, additional, and Song, Jingyuan, additional

Published
2023
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8. The genome of Corydalis reveals the evolution of benzylisoquinoline alkaloid biosynthesis in Ranunculales

Author

Xu, Zhichao, primary, Li, Zhen, additional, Ren, Fengming, additional, Gao, Ranran, additional, Wang, Zhe, additional, Zhang, Jinlan, additional, Zhao, Tao, additional, Ma, Xiao, additional, Pu, Xiangdong, additional, Xin, Tianyi, additional, Rombauts, Stephane, additional, Sun, Wei, additional, Van de Peer, Yves, additional, Chen, Shilin, additional, and Song, Jingyuan, additional

Published
2022
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14. The honeysuckle genome provides insight into the molecular mechanism of carotenoid metabolism underlying dynamic flower coloration

Author

Pu, Xiangdong, primary, Li, Zhen, additional, Tian, Ya, additional, Gao, Ranran, additional, Hao, Lijun, additional, Hu, Yating, additional, He, Chunnian, additional, Sun, Wei, additional, Xu, Meimei, additional, Peters, Reuben J., additional, Van de Peer, Yves, additional, Xu, Zhichao, additional, and Song, Jingyuan, additional

Published
2020
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17. Comparative genomics reveal the convergent evolution of CYP82D and CYP706X members related to flavone biosynthesis in Lamiaceae and Asteraceae.

Author

Gao, Ranran, Lou, Qian, Hao, Lijun, Qi, Guihong, Tian, Ya, Pu, Xiangdong, He, Chunnian, Wang, Yu, Xu, Wenjie, Xu, Zhichao, and Song, Jingyuan

Subjects
CONVERGENT evolution, SCUTELLARIA, BIOSYNTHESIS, LAMIACEAE, ASTERACEAE, CHINESE skullcap, COMPARATIVE genomics
Abstract

SUMMARY: Distant species producing the same secondary metabolites is an interesting and common phenomenon in nature. A classic example of this is scutellarein whose derivatives have been used clinically for more than 30 years. Scutellarein occurs in significant amounts in species of two different orders, Scutellaria baicalensis and Erigeron breviscapus, which diverged more than 100 million years ago. Here, according to the genome‐wide selection and functional identification of 39 CYP450 genes from various angiosperms, we confirmed that only seven Scutellaria‐specific CYP82D genes and one Erigeron CYP706X gene could perform the catalytic activity of flavone 6‐hydroxylase (F6H), suggesting that the convergent evolution of scutellarein production in these two distant species was caused by two independently evolved CYP450 families. We also identified seven Scutellaria‐specific CYP82D genes encoding flavone 8‐hydroxylase (F8H). The evolutionary patterns of CYP82 and CYP706 families via kingdom‐wide comparative genomics highlighted the evolutionary diversity of CYP82D and the specificity of CYP706X in angiosperms. Multi‐collinearity and phylogenetic analysis of CYP82D in Scutellaria confirmed that the function of F6H evolved from F8H. Furthermore, the SbaiCYP82D1A319D, EbreCYP706XR130A, EbreCYP706XF312D and EbreCYP706XA318D mutants can significantly decrease the catalytic activity of F6H, revealing the contribution of crucial F6H amino acids to the scutellarein biosynthesis of distant species. This study provides important insights into the multi‐origin evolution of the same secondary metabolite biosynthesis in the plant kingdom. Significance Statement: Here, we determined that the scutellarein accumulation in distant species from Lamiaceae and Asteraceae arose from the convergent evolution of Scutellaria‐specific CYP82D and Asteraceae‐specific CYP706X. The independent evolutionary pattern of CYP82 and CYP706 and the findings of crucial residues will provide novel insights into the convergent evolution of secondary metabolite biosynthesis in the plant kingdom. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Trends in herbgenomics

Author

Xin, Tianyi, primary, Zhang, Yu, additional, Pu, Xiangdong, additional, Gao, Ranran, additional, Xu, Zhichao, additional, and Song, Jingyuan, additional

Published
2018
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19. Genome Analysis of the Ancient Tracheophyte Selaginella tamariscina Reveals Evolutionary Features Relevant to the Acquisition of Desiccation Tolerance

Author

Xu, Zhichao, primary, Xin, Tianyi, additional, Bartels, Dorothea, additional, Li, Ying, additional, Gu, Wei, additional, Yao, Hui, additional, Liu, Sai, additional, Yu, Haoying, additional, Pu, Xiangdong, additional, Zhou, Jianguo, additional, Xu, Jiang, additional, Xi, Caicai, additional, Lei, Hetian, additional, Song, Jingyuan, additional, and Chen, Shilin, additional

Published
2018
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23. Comparative Genome Analysis of Scutellaria Baicalensisand Scutellaria BarbataReveals the Evolution of Active Flavonoid Biosynthesis

Author

Xu, Zhichao, Gao, Ranran, Pu, Xiangdong, Xu, Rong, Wang, Jiyong, Zheng, Sihao, Zeng, Yan, Chen, Jun, He, Chunnian, and Song, Jingyuan

Abstract

Scutellaria baicalensis(S. baicalensis) and Scutellaria barbata(S. barbata) are common medicinal plants of the Lamiaceae family. Both produce specific flavonoid compounds, including baicalein, scutellarein, norwogonin, and wogonin, as well as their glycosides, which exhibit antioxidant and antitumor activities. Here, we report chromosome-level genome assemblies of S. baicalensisand S. barbatawith quantitative chromosomal variation (2n= 18 and 2n= 26, respectively). The divergence of S. baicalensisand S. barbataoccurred far earlier than previously reported, and a whole-genome duplication(WGD) event was identified. The insertion of long terminal repeat elements after speciation might be responsible for the observed chromosomal expansion and rearrangement. Comparative genome analysis of the congeneric species revealed the species-specific evolutionof chrysin and apigenin biosynthetic genes, such as the S. baicalensis-specific tandem duplicationof genes encoding phenylalanine ammonia lyase and chalcone synthase, and the S. barbata-specific duplication of genes encoding 4-CoA ligase. In addition, the paralogous duplication, colinearity, and expression diversity of CYP82Dsubfamily members revealed the functional divergence of genes encoding flavone hydroxylase between S. baicalensisand S. barbata. Analyzing these Scutellariagenomes reveals the common and species-specific evolution of flavone biosynthetic genes. Thus, these findings would facilitate the development of molecular breeding and studies of biosynthesis and regulation of bioactive compounds.

Published
2020
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25. [Advances in the biosynthesis and application of bixin].

Author

Lou Q, Pu X, and Song J

Subjects
Humans, Pigmentation, Transcriptome, Bixaceae genetics, Carotenoids
Abstract

Since synthetic pigments are potentially harmful to human health, natural ones such as bixin, one of the carotenoids, are favored. As the second widely used natural pigment in the world, there is significant interest in the biosynthetic pathway of bixin which has not been fully elucidated. This review summarizes the chemical properties, extraction methods, biosynthetic pathway and application of bixin. In addition, we compared the difference between traditional extraction methods and new extraction techniques. Moreover, we described the genes involved in the biosynthetic pathway of bixin and the effects of abiotic stress on the biosynthesis of bixin, and discussed the application of bixin in food, pharmaceutical and chemical industries. However, the researches on bixin biosynthesis pathway are mostly carried out at the transcriptome level and most of the gene functions have not been elucidated. Therefore, we propose to characterize the entire bixin biosynthetic pathway using techniques of genomics, bioinformatics, and phytochemistry. This will help facilitate the synthetic biology research of bixin and development of bixin into new drugs.

Published
2021
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