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Psychoactive substance misuse tends to affect the social, economic, and mental health of young adult users and their parents. However, there is currently limited research on the challenges of parents of young adults who misuse psychoactive substances. The stress-strain-coping-support theoretical model was used to assess the challenges parents of young adults who misuse psychoactive substances encounter in Ghana. Based on interpretive phenomenology, we purposively sampled and conducted in-depth interviews with 15 parents from the Adum-Banso Health Centre. Data was processed with NVivo 12 pro data and analysed thematically with four stages of Interpretative Phenomenological Analysis (IPA). The challenges of parents of young adults engaged in psychoactive substance misuse included financial constraints, the onset of negative emotional effects on parents, structural challenges in pursuit of medical treatment, and stigma and discrimination. We have provided empirical data to inform policy decisions on establishing social protection and psychosocial support schemes for young adults misusing psychoactive substances and their parents to enhance the rehabilitation of young adults recovering from the impacts of psychoactive substance misuse.

Adolescence is characterised by intense experimentation. This study examined the prevalence and pattern of psychoactive substance use and common life events among adolescents abusing psychoactive substances in a Nigerian Hospital. The study employed cross-sectional descriptive method of 385 patients admitted for drug rehabilitation in the ABUAD Multisystem Hospital Ado Ekiti, Ekiti State Nigeria. Smoking and eating Marijuana (47.6%), eating Datura stramonium leaf (32.2%) and drinking alcohol (11.4%) were psychoactive substances commonly used among the respondents. The predominant life events among respondents included: heavy load of study (34.3%), study pressure from family (26.5%), family member serious illness (23.5%), scolding by parents (21.1%), and tired of learning (20.8%). Datura stramonium leaf abuse is an emerging psychoactive substance among the respondents. Relevant stakeholders should be aware of the new trend in drug use among adolescents and coordinated effort should be made to stop the trend. [ABSTRACT FROM AUTHOR]

IntroductionPsychedelic compounds such as LSD, psilocybin, mescaline, and DMT can dramatically alter visual perception. However, the extent to which visual effects of psychedelics consistently vary for different substances is an open question. The visual effects of a given psychedelic compound can range widely both across and within individuals, so datasets with large numbers of participants and descriptions of qualitative effects are required to adequately address this question with the necessary sensitivity.MethodsHere we present an observational study with narrative self-report texts, leveraging the massive scale of the Erowid experience report dataset. We analyzed reports associated with 103 different psychoactive substances, with a median of 217 reports per substance. Thirty of these substances are standardly characterized as psychedelics, while 73 substances served as comparison substances. To quantitatively analyze these semantic data, we associated each sentence in the self-report dataset with a vector representation using an embedding model from OpenAI, and then we trained a classifier to identify which sentences described visual effects, based on the sentences’ embedding vectors.ResultsWe observed that the proportion of sentences describing visual effects varies significantly and consistently across substances, even within the group of psychedelics. We then analyzed the distributions of psychedelics’ visual effect sentences across different categories of effects (for example, movement, color, or pattern), again finding significant and consistent variation.DiscussionOverall, our findings indicate reliable variation across psychedelic substances’ propensities to affect vision and in their qualitative effects on visual perception.

Abstract Computational intelligence techniques have emerged as a promising approach for diagnosing various medical conditions, including memory impairment. Increased abuse of psychoactive drugs poses a global public health burden, as repeated exposure to these substances can cause neurodegeneration, premature aging, and negatively affect memory impairment. Many studies in the literature relied on statistical studies, but they remained inaccurate. Some studies relied on physical data because the time factor was not considered, until Artificial Intelligence (AI) techniques came along that proved their worth in this diagnosis. The variable deep neural network method was used to adapt to the intermediate results and re-process the intermediate in case the result is undesirable. Computational intelligence was used in this study to classify a brain image from MRI or CT scans and to show the effectiveness of the dose ratio on health with treatment time, and to diagnose memory impairment in users of psychoactive substances. Understanding the neurotoxic profiles of psychoactive substances and the underlying pathways is hypothesized to be of great importance in improving the risk assessment and treatment of substance use disorders. The results proved the worth of the proposed method in terms of the accuracy of recognition rate as well as the possibility of diagnosis. It can be concluded that the diagnostic efficiency is increased by increasing the number of hidden layers in the neural network and controlling the weights and variables that control the deep learning algorithm. Thus, we conclude that good classification in this field may save human life or early detection of memory impairment.

Computational intelligence techniques have emerged as a promising approach for diagnosing various medical conditions, including memory impairment. Increased abuse of psychoactive drugs poses a global public health burden, as repeated exposure to these substances can cause neurodegeneration, premature aging, and negatively affect memory impairment. Many studies in the literature relied on statistical studies, but they remained inaccurate. Some studies relied on physical data because the time factor was not considered, until Artificial Intelligence (AI) techniques came along that proved their worth in this diagnosis. The variable deep neural network method was used to adapt to the intermediate results and re-process the intermediate in case the result is undesirable. Computational intelligence was used in this study to classify a brain image from MRI or CT scans and to show the effectiveness of the dose ratio on health with treatment time, and to diagnose memory impairment in users of psychoactive substances. Understanding the neurotoxic profiles of psychoactive substances and the underlying pathways is hypothesized to be of great importance in improving the risk assessment and treatment of substance use disorders. The results proved the worth of the proposed method in terms of the accuracy of recognition rate as well as the possibility of diagnosis. It can be concluded that the diagnostic efficiency is increased by increasing the number of hidden layers in the neural network and controlling the weights and variables that control the deep learning algorithm. Thus, we conclude that good classification in this field may save human life or early detection of memory impairment. [ABSTRACT FROM AUTHOR]

Dans les Aventures de Tintin , Hergé n'a pas manqué de tisser psychologie et psychiatrie dans la trame de fond de son récit. Étant donné la richesse de ses planches en matière de santé et de maladie mentales, nous proposons une revue systématique des albums ainsi que de la littérature médicale aboutissant à une lecture de la sémiologie et de la phénoménologie psychiatriques dans l'œuvre d'Hergé. Les thèmes les plus récurrents sont les délires et les psychoses, les troubles de la personnalité ainsi que les troubles liés à l'usage de l'alcool et d'autres substances psychoactives. Par la suite, nous avons procédé à une analyse de l'évolution de la représentation des asiles et des hôpitaux psychiatriques, des psychiatres et du « fou » au fil des albums. Finalement, nous nous sommes attardés sur l'analyse psychanalytique des « Aventures de Tintin », entreprise par Serge Tisseron, à la recherche d'un secret familial qu'il eut l'impression de déceler en parcourant l'œuvre d'Hergé. Hergé's "Adventures of Tintin" is a renowned Belgian comic book series. The twenty-four albums are rich in psychological and psychiatric elements, intricately woven into a smartly written and complex storyline. These elements have, however, seldom been studied systematically from a psychiatric point of view. In the current paper, we propose a systematic review of the series and of the medical literature concerning the psychiatric semiology and phenomenology found in the work of Hergé. The search terms used in the Pubmed database were "Tintin", "medicine", "medical", "health", "mental", and "psychiatry". Upon reading the integrality of the twenty-four albums, the most recurrent themes found were delusions and psychosis, personality disorders, and alcohol and other psychoactive substance use disorders. We then conduct a chronological analysis of the evolution of the representations of asylums and psychiatric hospitals, psychiatrists and the "mad man" throughout the albums. Finally, we present the psychoanalysis of the "Adventures of Tintin", as developed by the psychiatrist and psychoanalyst Serge Tisseron, who, upon reading Hergé's work, suspected the existence of a family secret that the author might have concealed in his albums. [ABSTRACT FROM AUTHOR]

The aim of the study was to evaluate the prevalence of psychoactive substance abuse and association of single nucleotide polymorphisms in Cannabinoid-Receptor 1 (CNR1) gene with chronic polysubstance use among the Nigerian male commercial vehicle drivers selected from the three major ethnic groups in Nigeria. A-10-Panel Generic Multi Drug Urine Dip Card Test Kit was used in the study and four SNPs (rs2023239, rs806378, rs806379 and rs806381)in CNR1 were genotyped in 60 subjects (20 drivers from each ethnic group) by using Sequenom MassARRAY Genotyping System. The four target SNPs revealed the following genotypes namely rs2023239: CC (20%), CT (40%), TT (40%); rs806378: CC (100%); rs806379: AA (20%), AT (50%), TT (30%); rs806381: AA (50%), GA (50%) in cases among the Hausa drivers. However, among the Igbo drivers, the four target SNPs showed the following genotypes namely rs2023239: CC (20%), CT (40%), TT (40%); rs806378: CC (80%) CT (20%); rs806379: AA (10%), AT (50%), TT (40%) and rs806381: AA (30%), GA (70%) in cases. Additionally, the target SNPs also revealed the following genotypes namely rs2023239: CC (30%), CT (30%), TT (40%); rs806378: CC (90%), CT (10%); rs806379: AA (10%), AT (60%), TT (30%) and rs806381: AA (70%), GA (20%), GG (10%) in cases among the Yoruba drivers. The SNPs rs2023239, rs806378 and rs806381 were significantly linked with polysubstance and chronic cannabis use in the sample population (Hausa, Igbo and Yoruba) (p˂0.05). The SNP rs806379 associated significantly with polysubstance and chronic cannabis use in the Igbo drivers only (p˂0.05). Conclusively, this study provides probably the first data on the association of CNR1genetic polymorphism with chronic polysubstance use among Nigerian male commercial motor vehicle drivers. [ABSTRACT FROM AUTHOR]

Background: The use of drugs and other psychoactive substances by students poses a significant risk to public health that affects multiple aspects of individuals' lives, including health, social interactions, and the economy. As a result, this research seeks to evaluate the level of understanding and the perceived consequences of psychoactive substances among undergraduate students at Achievers University in Owo, Ondo state. Materials and Methods: This descriptive cross-sectional research was conducted between September 2022 and November 2022. A total of 351 students from different departments were selected using a multistage sampling technique. The researchers utilized a self-structured questionnaire that was validated to gather data that aligns with the objectives of the study. The acquired data were then codified and analyzed through descriptive and Chi-square tests set with a significance level of 0.05 using SPSS version 25. Results: Out of 351 individuals surveyed, a majority of 88.3% were aware of the existence of illegal drugs. Among them, 22.2% were found to be currently abusing such substances, whereas 20.5% acquired them from friends. Respondents reported abusing various substances, including alcohol (20.5%), tramadol (13.4%), coffee (11.4%), cigarettes (18.2%), stimulants (2.0%), marijuana (2.0%), and tobacco (16.8%). The use of psychoactive substances was found to have negative impacts on individuals, such as low self-esteem (47.9%), despair (27.1%), psychiatric disorders (17.1%), social isolation (17.9%), increased violence (23.4%), and an increased risk of overdose and suicide (11.4%). Furthermore, there was a significant correlation between education level, religion, and knowledge of psychoactive substances (P < 0.05). Conclusion: The study findings indicate that the misuse of psychoactive substances is prevalent among the surveyed population, with adverse effects on mental health, heightened risk of engaging in illegal activities, and increased likelihood of overdose and suicide fatalities. As a result, we recommend that the university and other religious organizations undertake a suitable drug education campaign.

Background: Psychosis is defined as a series of symptoms that impair the mind and lead to a kind of loss of reference to reality. Development of psychosis is usually preceded by the appearance of prodromal symptoms. Numerous attempts have been made to find out how psychoactive substances can influence the onset and development of psychotic disorders, but to date there are no studies that show a link between the onset of prodromal symptoms and the use of psychoactive substances. Methods: A survey consisting of epidemiological and demographic questions, the Drug Use Disorders Identification Test (DUDIT), and the Prodromal Questionnaire Brief Version (PQ-B) was conducted on social media among users of illegal psychoactive substances, covering 703 study participants. Results: A total of 39.8% of the respondents had been treated by a psychiatrist, and the most popular drugs used by respondents in their lifetime were tetrahydrocannabinol-containing products, MDMA, amphetamines, and LSD. A significant correlation was found between the DUDIT and the PQ-B values. Conclusions: Intensity of psychoactive substance use correlated positively with the risk of appearance and intensity of prodromal symptoms of psychosis. Early exposure to psychoactive substances increased the risk of heavy substance use in adulthood and led to more frequent prodromal states. [ABSTRACT FROM AUTHOR]

The aim of the study was to evaluate the prevalence of psychoactive substance abuse and association of single nucleotide polymorphisms in Cannabinoid-Receptor 1 (CNR1) gene with chronic polysubstance use among the Nigerian male commercial vehicle drivers selected from the three major ethnic groups in Nigeria. A-10-Panel Generic Multi Drug Urine Dip Card Test Kit was used in the study and four SNPs (rs2023239, rs806378, rs806379 and rs806381)in CNR1 were genotyped in 60 subjects (20 drivers from each ethnic group) by using Sequenom MassARRAY Genotyping System. The four target SNPs revealed the following genotypes namely rs2023239: CC (20%), CT (40%), TT (40%); rs806378: CC (100%); rs806379: AA (20%), AT (50%), TT (30%); rs806381: AA (50%), GA (50%) in cases among the Hausa drivers. However, among the Igbo drivers, the four target SNPs showed the following genotypes namely rs2023239: CC (20%), CT (40%), TT (40%); rs806378: CC (80%) CT (20%); rs806379: AA (10%), AT (50%), TT (40%) and rs806381: AA (30%), GA (70%) in cases. Additionally, the target SNPs also revealed the following genotypes namely rs2023239: CC (30%), CT (30%), TT (40%); rs806378: CC (90%), CT (10%); rs806379: AA (10%), AT (60%), TT (30%) and rs806381: AA (70%), GA (20%), GG (10%) in cases among the Yoruba drivers. The SNPs rs2023239, rs806378 and rs806381 were significantly linked with polysubstance and chronic cannabis use in the sample population (Hausa, Igbo and Yoruba) (p˂0.05). The SNP rs806379 associated significantly with polysubstance and chronic cannabis use in the Igbo drivers only (p˂0.05). Conclusively, this study provides probably the first data on the association of CNR1genetic polymorphism with chronic polysubstance use among Nigerian male commercial motor vehicle drivers.

The use of psychoactive substances by adolescents is one of the more serious problems of modern society. Socio-cultural context plays a significant role in influencing the form of psychoactive substance use. The aim is to show the most important sociocultural factors for psychoactive substance use among adolescence, as well as a show and analysis of studies on the use of psychoactive substance use in adolescents about cultural, racial, and ethnic affiliation. Identified factors that belong to the category of sociocultural determinants are the quality of family relationships and dynamics; peer pressure; part of the city or other place where young people live, stay and/or go to school; social norms, expectations, and beliefs; legal regulations, and the general characteristics of the society. In the analyzed studies, alcohol is the most used substance among adolescents, and marijuana is the most used illegal psychoactive substance. Male adolescents are more likely to use psychoactive substances, than girls. A high prevalence of the use of psychoactive substances was registered among American Indian adolescents and young people in Colombia, while a low prevalence was recorded in Asian countries. Patterns of drug use among youth were analyzed in several tribes living in India, Thailand, and the United States. Tobacco, alcohol, and opium are the most used substance in members of these tribes.

ObjectiveTo establish an LC-MS/MS method based on single hair micro-segmental technique, and verify the detection of 42 psychoactive substances in 0.4 mm hair segments.MethodsEach piece of single hair was cut into 0.4 mm segments and extracted by sonication and the segments were immersed in dithiothreitol-containing extraction medium. Mobile phase A was the aqueous solution containing 20 mmol/L ammonium acetate, 0.1% formic acid, and 5% acetonitrile. Mobile phase B was acetonitrile. An electrospray ionization source in positive ion mode was used for data acquisition in multiple reaction monitoring （MRM） mode.ResultsThe 42 psychoactive substances in hair had a good linear relationship within their respective linear ranges （r>0.99）, the limits of detection were 0.2-10 pg/mm, the limits of quantification were 0.5-20 pg/mm, the intra-day and inter-day precisions were 1.5%-12.7%, the intra-day and inter-day accuracies were 86.5%-109.2%, the recovery rates were 68.1%-98.2%, and the matrix effects were 71.3%-111.7%. The method was applied to hair samples collected from one volunteer at 28 d after a single dose of zolpidem, with zolpidem detected in 5 hairs was 1.08-1.60 cm near the root tip, and the concentration range was 0.62-20.5 pg/mm.ConclusionThe micro-segmental technique of single hair analysis can be applied to the investigation of drug-facilitated sexual assault cases.

Psychoactive substance experimentation among Tunisian adolescents remains one of the most threatening public health concerns. In spite of this, little is known about the prevalence and predictors of these behaviors in the Tunisian context. This study aims to assess the prevalence of tobacco, alcohol and illicit drug experimentation and its predictive factors among adolescents in the delegation of Nfidha, Sousse governorate, Tunisia. We conducted a cross sectional study in middle and high schools in the delegation of Nfidha, Sousse governorate, Tunisia, during the first trimester of the 2019–2020 school year using an anonymous questionnaire self-administered to a randomly drawn representative sample of 1,352 pupils. Data collected included socio-demographic characteristics, substance experimentation among school-adolescents, academic performance as well as family and peer' factors. Tobacco was the most commonly experimented substance with a prevalence rate of 17.5 % (CI 95 %: 14.8–18.8 %). The prevalence of alcohol and illicit drugs use were 3.3 % [CI 95 %: (2.1–3.9 %)] and 2 % [CI 95 %: (1.1–2.6 %)] respectively. Being male (Adjusted (AOR)=4.09, p<0.001), being a high school pupil (AOR=2.81, p<0.001), having experiencing academic failure (AOR=1.60, p=0.007) and having a father and siblings who use tobacco (AOR=1.72, p=0.002; AOR=2.03, p=0.001 respectively) were the predictors of tobacco experimentation in the multivariate logistic regression analysis. Additionally, being male (AOR=8.40, p<0.001), having experienced academic failure (AOR=2.76, p=0.017) as well as having a father and siblings who use alcohol (AOR=5.90, p<0.001; AOR=3.03, p=0.045 respectively) and having experienced tobacco (AOR=4.28, p<0.001) were the determinants of alcohol experimentation. Similarly, having a history of academic failure (AOR=3.44, p=0.041), having peers who use illicit drugs (AOR=3.22, p=0.028), having a history of tobacco and alcohol experimentation (AOR=6.52, p<0.001; AOR=3.49, p=0.046 respectively) were the predictors of illicit drug experimentation among adolescents. A substantial number of socio-demographic and environmental factors have been identified as being involved in experimentation with psychoactive substance during adolescence. Therefore, further prevention programs targeting not only adolescents, but also all risk factors are needed. [ABSTRACT FROM AUTHOR]

Introduction: Attention-deficit/hyperactivity disorder (ADHD) was originally treated as a neurodevelopmental disorder that occurs mainly in children and tends to diminish or disappear with age, but we now know that symptoms persist into adulthood in over 50% of ADHD patients. Undiagnosed individuals often turn to psychoactive substance to minimize the negative aspects of functioning and improve quality of life. Methods: The study was conducted online using random sampling through a Facebook group administered by physicians and targeted to patients diagnosed with ADHD. The study was naturalistic and exploratory, therefore no hypothesis was made. 438 correctly completed questionnaires were received. Analysis of the results showed that people with ADHD turn to psychoactive substances relatively frequently. Results: The most commonly used stimulants include alcohol, marijuana, 3,4- methylenedioxymethamphetamine (MDMA), amphetamine/methamphetamine, and psilocybin. In the study population, methylphenidate is the most commonly used drug among patients. After treatment with psychostimulants, the majority of respondents note a decrease in symptoms of hyperactivity disorder, especially in male patients. Conclusion: It is necessary to perform proper diagnostics and actively look for ADHD symptoms in patients who tend to use psychoactive substances. [ABSTRACT FROM AUTHOR]

Drugs of abuse has drawn intense attention due to increasing concerns to public health and safety. The construction of a sensing platform with the capability to identify them remains a big challenge because of the limitations of synthetic complexity, sensing scope and receptor extendibility. Here a kind of poly(ionic liquid) (PIL) photonic crystal spheres doped with aggregation‐induced emission (AIE) luminogens was developed. As diverse noncovalent interactions involve in PIL moieties, the single sphere shows different binding affinity to a broad range of psychoactive substances. Furthermore, the dual‐channel signals arising from photonic crystal structures and sensitive AIE‐luminogens provide high‐dimensional information for discriminative detection of targets, even for molecules with slight structural differences. More importantly, such single sphere sensing platform could be flexibly customized through ion‐exchange, showing great extendibility to fabricate high‐efficiency/high‐throughput sensing arrays without tedious synthesis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Social Sciences & Humanities Studies / Društvene i Humanističke Studije (DHS) is the property of Faculty of Humanities & Social Sciences, University of Tuzla and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BackgroundThe prevalence of psychoactive substance use is increasing worldwide and identifying adverse effects of these types of drugs is necessary in intoxicated patients.ObjectiveWe aimed to investigate the association of psychoactive substance intoxication with their adverse effects on the functioning of the bodily organs.MethodsThis was a single-center study between March 2019 and April 2022 on intoxicated patients with psychoactive substances. Inclusion criteria were intoxication with alcohol, opioids, and stimulants, and having available results of laboratory biomarkers. Demographic and clinical data of patients at the time of admission as well as during hospitalization were reviewed, retrospectively. Data were analyzed using a generalized linear mixed model in R software and the Adjusted Odds Ratio (AOR) was estimated.ResultsA total of 800 hospitalized patients in the ICU (n = 400) and general ward (n = 400) were divided into two groups of intoxicated with alcohol (n = 200) and opioids or stimulants (n = 200). Liver (AOR = 0.15, p = 0.033; AOR = 0.13, p = 0.007) and kidney (AOR = 0.46, p = 0.004; AOR = 0.24, p = 0.021) dysfunction occurred less in the ICU and general ward, respectively, in opioids or stimulants intoxication compared to alcohol. Cardiovascular dysfunctions occurred more in opioids or stimulants intoxication compared to alcohol in both ICU (AOR = 10.32, p

IntroductionAttention-deficit/hyperactivity disorder (ADHD) was originally treated as a neurodevelopmental disorder that occurs mainly in children and tends to diminish or disappear with age, but we now know that symptoms persist into adulthood in over 50% of ADHD patients. Undiagnosed individuals often turn to psychoactive substance to minimize the negative aspects of functioning and improve quality of life.MethodsThe study was conducted online using random sampling through a Facebook group administered by physicians and targeted to patients diagnosed with ADHD. The study was naturalistic and exploratory, therefore no hypothesis was made. 438 correctly completed questionnaires were received. Analysis of the results showed that people with ADHD turn to psychoactive substances relatively frequently.ResultsThe most commonly used stimulants include alcohol, marijuana, 3,4-methylenedioxymethamphetamine (MDMA), amphetamine/methamphetamine, and psilocybin. In the study population, methylphenidate is the most commonly used drug among patients. After treatment with psychostimulants, the majority of respondents note a decrease in symptoms of hyperactivity disorder, especially in male patients.ConclusionIt is necessary to perform proper diagnostics and actively look for ADHD symptoms in patients who tend to use psychoactive substances.

• This study validated the Psychoactive Substance Refusal Self-Efficacy Questionnaire (PSRSEQ) in Chinese adolescents in Hong Kong. • The psychometric properties of the 1-factor structure performed better than the original 3-factor one of PSRSEQ. • The validated PSRSEQ would facilitate future research and interventions on refusal self-efficacy for psychoactive substance use. Self-efficacy is a key concept in various behavioral theories. Refusal self-efficacy is important in understanding issues related to psychoactive substance use. To facilitate related research, this study translated and validated the Chinese version of the 14-item Psychoactive Substance Refusal Self-efficacy Questionnaire (PSRSEQ) among adolescents. There is a debate about whether such a refusal self-efficacy scale should be unidimensional or multidimensional. A survey was conducted among 601 adolescent case-clients of social workers in Hong Kong from July 2021 to June 2022. Various psychometric properties were examined. The confirmatory factor analysis (CFA) supported the original 3-factor structure of the PSRSEQ (emotional relief, opportunistic, and social facilitation refusal self-efficacy), which showed satisfactory psychometric properties (internal consistency, convergent validity in terms of significant negative correlations with the intention of psychoactive substance use in the next year and psychoactive substance use behavior in the past six months, and the absence of floor effect) but ceiling effect was obvious. Notably, unacceptable discriminant validity of one subscale and strong correlations among the three subscales were observed. In another set of analyses using two split-half subsamples, the exploratory factor analysis identified a 1-factor 14-item structure, which was confirmed by CFA and showed satisfactory psychometric properties. The 1-factor PSRSEQ, instead of the one having a 3-factor structure, was preferred and recommended to assess psychoactive substance refusal self-efficacy among Chinese adolescents. It is warranted to validate the scale in other adolescent and age groups in future studies. [ABSTRACT FROM AUTHOR]

The use of "bath salts" or other new psychoactive substances, otherwise known as "legal highs", is increasing. Illicit drug use during pregnancy is not uncommon. Nevertheless, literature reporting bath salts and their effect on pregnancy is scant. Besides, there seems to be no literature about bath salts and conduct of general anesthesia. This case report describes a general anesthetic for the surgical delivery of an infant to a woman under the acute influence of bath salts and methamphetamines.

Addictovigilance is a French health monitoring system, composed of 13 centres distributed across the national territory, that aims to monitor cases of abuse, misuse, or use disorders related to psychoactive substances. Fulfilling these missions requires a regional network that ensures efficient information flow, dissemination to health authorities, and subsequent downward communication to prevent risks. This was illustrated through the example of nitrous oxide misuse. The Nantes Addictovigilance Centre, which is responsible for nitrous oxide monitoring, has highlighted the emergence of a signal from the very first cases. Since 2018, 6 national addictovigilance reports have subsequently been produced highlighting the increase in this signal in quantitative terms and in qualitative terms, with a diversification and worsening of complications (use disorders, neurological, psychiatric, cardiac and more recently thromboembolic). At the local and regional level, each addictovigilance centre has relayed information to its network, in a variety of ways, but also to the general public, particularly through the media. Studies have also been carried out to better quantify and qualify nitrous oxide consumption. These signals from addictovigilance data have been the subject of numerous national and international communications (health authorities, addictovigilance network, international scientific articles). They have also contributed to the promulgation of the French law of June 2021 aimed to prevent dangerous uses of nitrous oxide, and international reporting. The addictovigilance centres have made it possible to obtain an early, rapid and accurate signal with pharmacological and medical data. Nitrous oxide is an example of the wide potential of action of the French addictovigilance network, in all its fields of competence: training, specific collection, research and information., (Copyright © 2024. Published by Elsevier Masson SAS.)

The objective of this review is to determine the state of psychoactive substance use in the department of Quindío, Colombia, for which a systematic documentary review was carried out using a Prisma-P protocol matrix as a model. It was found that there is an increase in the consumption of psychoactive substances in Quindío, which is analogous to the situation in Colombia, and that the age of onset is increasingly younger, which places young people and adolescents as the population at greatest risk of consumption, recidivism and substance abuse. Consumption was associated with confinement and an increase in intrafamily violence during the pandemic, while a vulnerability factor is being a woman, a mother and head of household, and living with a partner who is a consumer. There has also been an increase in micro-trafficking and experimentation with new designer drugs, a situation that boomed during the pandemic confinement, and which has spread and continues in the post-pandemic or "new normal". [ABSTRACT FROM AUTHOR]

Copyright of Hamidiye Medical Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract Background Psychoactive substance use is a public health challenge among young people in informal settlements. Though rarely examined, psychoactive substance use is linked to sexual expectancies and inhibitions, and consequently high-risk sexual behaviours. This study examined the association between sexual expectancies and inhibitions, and high-risk sexual behaviours among young psychoactive substance users (PSUs) in informal settlements in Kampala, Uganda. Methods This cross-sectional study recruited 744 young PSUs from informal settlements in Kampala. Respondent driven sampling was used to recruit respondents. A ‘modified’ Poisson regression model was used for inferential statistics. Data were analysed using the Stata 14 software. Results Of the 744 study participants, 45.6% believed that psychoactive substance use improves sexual performance; 43.3% believed that psychoactive substances make sex more pleasurable, and 53.3% believed that psychoactive substances give courage or confidence to approach a partner for sex. The belief that psychoactive substance use improves sexual performance (PR 1.14, 95% CI: 1.01–1.30), increases the likelihood of engaging in sex (PR 1.20, 95% CI: 1.04–1.40) or gives courage or confidence to approach a sexual partner (PR 1.21, 95% CI: 1.05–1.39) were associated with having sex while under the influence of psychoactive substances. The belief that a psychoactive substance user under the influence of psychoactive substances is more likely to engage in sex (PR 1.48, 95% CI: 1.15–1.90), and likely to find it difficult to refuse sex (PR 1.28, 95% CI: 1.06–1.55) were positively associated with engaging in multiple sexual partnerships. The belief that one easily forgets to use a condom when under the influence of psychoactive substances was positively associated with inconsistent condom use (PR 1.26, 95% CI: 1.09–1.45). Conclusion Psychoactive substance use expectancies associated with high-risk sexual behaviours included the belief that psychoactive substances improve sexual performance and improve confidence in approaching a sexual partner. Psychoactive substance use inhibitions associated with high-risk sexual behaviours included an increased likelihood of engaging in sexual intercourse, difficulties in refusing to engage in sexual intercourse, and forgetting to use condoms while intoxicated. Interventions targeting a reduction in high-risk sexual behaviour should integrate the impact of psychoactive substance use on sexual behaviour.

Aim: Patterns and prevalence of psychoactive drug use are unique in the professions and vary by profession as well as by type of practice (e.g., private/public), gender, and career stage. In this study, we attempt to summarise the results of research over the past decades on the use of illegal substances by law enforcement officers. Methodology: A literature search was performed in PubMed, HeinOnline, GoogleScholar and other relavant database (such as US Department of Justice) from their inception through April 2022. Findings: In total, 26 studies met the search criteria. Research data clearly indicates that, in addition to alcohol and smoking, the use of illegal drugs is also prevalent among police officers. Our review shows that the prevalence of illcit drug use ranges widely (0,22% – 21,6%). Results suggest that estimates of the prevalence of illegal substance abuse by police are influenced by a number of factors, such as: research methodology. deliberate distortion of data; social differences. Value: Studies on substance abuse by police officers focus on legal drug consumption (alcohol and smoking) and mostly do not address illicit drug use. However, limited results show that, in addition to alcohol consumption and smoking, police officers also use illegal drugs. There are many consequences of drug use by police officers.

Introduction: psychoactive substances are chemicals that affect the nervous system and alter the activity in the brain. Such substances include alcohol and other illicit drugs. This research study aimed to determine the prevalence and pattern of psychoactive substance use among students at a government secondary school in Ilorin, Kwara State, Nigeria. Methods: this study adopts a crosssectional descriptive survey design. A simple random sampling technique was used to select 104 students for an invitation to fill a semi-structured questionnaire after consenting to the informed consent. Correlational analyses were performed between social characteristics and the knowledge of the effects and prevalence of substance use. Results: thirty-three point seven percent (33.7) of students reported to use psychoactive substances, with alcohol and tramadol being the most consumed. Those aged 15-19 years were found to have a higher prevalence of substances use than other ages. There was an important knowledge of the social perspective and health effects of using such substances, but they persisted in their consumption. Age and school level were observed to have a statistically significant correlation with the knowledge of the effects of drug use. Conclusion: our study shows that the prevalence and pattern of psychoactive substance use among the students are high considering their level and age. The majority of the students knew about psychoactive substance use and its social and health effects. We, therefore, recommend a multistakeholder effort within the community to curtail drug use among young people. [ABSTRACT FROM AUTHOR]

La consommation de drogues est observée dans toutes les sociétés humaines. Ces substances ont de multiples fonctions – recherche de plaisir, soin, convivialité, etc. – et des statuts qui évoluent dans le temps puisqu'elles peuvent être légales ou illégales, disponibles en accès libre ou sous certaines conditions. Elles sont souvent associées à la notion de danger. La mise en place d'indicateurs de suivi aide les pouvoirs publics à légiférer et à évaluer leur balance bénéfice-risque. Drug use is observed in all human societies. These substances have multiple functions – pleasure seeking, care, conviviality, etc. – and statuses that evolve over time since they can be either legal or illegal, freely available or under certain conditions. They are often associated with the notion of danger. The establishment of monitoring indicators helps public authorities to legislate and to evaluate their benefit-risk balance. [ABSTRACT FROM AUTHOR]

Aim: Patterns and prevalence of psychoactive drug use are unique in the professions and vary by profession as well as by type of practice (e.g., private/public), gender, and career stage. In this study, we attempt to summarise the results of research over the past decades on the use of illegal substances by law enforcement officers. Methodology: A literature search was performed in PubMed, HeinOnline, GoogleScholar and other relavant database (such as US Department of Justice) from their inception through April 2022. Findings: In total, 26 studies met the search criteria. Research data clearly indicates that, in addition to alcohol and smoking, the use of illegal drugs is also prevalent among police officers. Our review shows that the prevalence of illcit drug use ranges widely (0,22% - 21,6%). Results suggest that estimates of the prevalence of illegal substance abuse by police are influenced by a number of factors, such as: research methodology. deliberate distortion of data; social differences. Value: Studies on substance abuse by police officers focus on legal drug consumption (alcohol and smoking) and mostly do not address illicit drug use. However, limited results show that, in addition to alcohol consumption and smoking, police officers also use illegal drugs. There are many consequences of drug use by police officers. [ABSTRACT FROM AUTHOR]

Background: Psychoactive substance use is frequently encountered in hospitals' emergency departments (EDs). It accounts for major health-care problems frequently leading to accident and ED admissions, yet it is frequently unidentified. The aim of this study was to determine the prevalence and pattern of psychoactive substance use among patients presenting in the Accident and EDs and to compare the case detection rate of psychoactive substance use between self-report questionnaire and biochemical markers (e.g., urine toxicology). Methods: To achieve this, 200 consenting participants attending the accident and emergency unit of a tertiary hospital were consecutively enlisted into the study within 2 weeks. They were screened for psychoactive substance use with the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) and the urine drug test (UDT). Results: The lifetime prevalence of psychoactive substance use was 45.5%, while the past 3 months (recent use) prevalence was 27.0%. The pattern of psychoactive substance use revealed that alcohol was the predominant psychoactive substance use with a lifetime prevalence of 13.0% and recent use of 12.0%. The UDT significantly detected more patients who used psychoactive substance compared to self-report (P < 0.001). Conclusion: The prevalence of drug use recorded among attendees of the accident and emergency unit was high in this study. The UDT significantly detected more patients who used psychoactive substances compared to self-report (P < 0.001). Several patients with major health problems as a result of psychoactive substance use were identified with the aid of these screening tools.

Introduction: Substance abuse refers to the harmful or hazardous use of any psychoactive substance including licit and illicit drugs, other than when medically indicated. According to a UN report, 1 million heroin addicts are registered in India, and unofficially, there are as many as 5 million. Among all the states Punjab stood third in substance abuse and also injectable drug use. The present study was thus conducted to assess the sociodemographic profile and pattern of substance abuse among patients attending a Drug de-addiction centre. Material and Methods: A record-based analysis from March 2015 to March 2019 was done. Substance dependence was diagnosed post detailed clinical interview by a consultant psychiatrist at the center using DSM -10. For the 966 registered patients admitted in the last four years, the record was checked for completeness of data and relevant information on socio-demographic profile, substance abused, duration of hospital stays, drop out and relapse rates was extracted. Results: Of the total admitted patients (n= 966) 100% addicts were of male gender and natives of Punjab. 514 (53.21%) were married followed by 434(44.93%) never married. Maximum patients 456(47.20%) were self-employed. Heroin was the most abused drug. The injecting route of drug abuse was used by most of the abusers i.e. 51.66%. Only 173 (17.90%) patients dropped out of the treatment followed by relapse in 192 (19.88%). Conclusion: In this paper we demonstrated the vulnerability of young population towards drug addiction. Easy accessibility of drugs, peer pressure and difficult family circumstances raises the fragility to restore for substance use. However, community-based studies are imperative in order to estimate how big is the problem at the bottom.

Psychoactive substances are ubiquitous in the environment at low concentrations, and tobacco, cannabis, etc. are all widely-existing examples. Given their potent biological activity, psychoactive substances are suspected to be harmful to the environment, and reports of their ecological risks are gradually increasing. Since the 1990s, the investigations into psychoactive substances have made remarkable progress, yet some research fields still need to be modernised. For example, the unification of standardised analytical methods as well as the supplementation of occurrence literature. In addition, a relatively lagging risk evaluation system caused by a lack of toxicity data is particularly in need of improvement. The purpose of this article is to develop a review of current research on psychoactive substances, including analytical methods, distribution in environmental compartments, and ecological risk assessment, as well as to point out deficiencies and development prospects and to offer motivation for enhancing the research level in this field.

Background: Caffeine is a commonly consumed psychoactive substance with potential effects on sleep quality. However, few studies have examined this relationship in the general population of Makkah, Saudi Arabia., Objective: To investigate the impact of caffeine consumption on sleep quality and identify demographic factors associated with caffeine intake and sleep quality in Makkah's general population., Methods: This cross-sectional study used a convenient sampling approach to recruit 390 individuals residing in Makkah. Data were collected via a Google Forms questionnaire distributed through various social media platforms. Caffeine intake and sleep quality were assessed using a validated questionnaire adapted for Saudi Arabia and the Pittsburgh Sleep Quality Index (PSQI), respectively., Results: The median total daily caffeine intake was 324.20 mg, with 43.1% of participants consuming more than the suggested cutoff of 400 mg daily. There were significant positive correlations between PSQI and total caffeine consumption in the morning, evening, and overall daily consumption. The results also indicated significant relationships between demographic factors, such as marital status, educational level, income, and BMI groups, and caffeine consumption., Conclusion: Caffeine intake was found to be high among the general population of Makkah, with a significant portion consuming more than the suggested daily limit. There was a significant positive correlation between caffeine consumption and poor sleep quality. Additionally, demographic factors such as marital status, educational level, income, and BMI groups were found to be associated with caffeine consumption., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Review Board (IRB) at Makkah Health Administration issued approval H-02-K-076-0124-1065. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Khan et al.)

In aquatic systems, some substances considered as endocrine disruptors have been detected, which can be due to their incomplete elimination in wastewater treatment plants (WWTPs) and inadequate disposal of pharmaceuticals. Among these contaminants are 17α-ethinylestradiol (EE2) and caffeine (CAF). Moreover, it has been reported that this kind of contaminants may provoke different adverse effects in many aquatic organisms. Because of that, in the present study, up-flow anaerobic sludge blanket reactors (UASB) coupled with the Fenton process was evaluated for EE2 and CAF removal spiked in wastewater samples. First, the best reaction conditions were established in each process. For UASB reactor, two hydraulic retention times (HRT 8 and 24 h) were evaluated, achieving the highest chemical organic demand (COD) removal (70 %) and drug elimination (84 %–86 %) with HRT 24 h. Subsequently, Fenton process was conducted at pH 3 with different levels of Fe2+ (0.05–0.5 mmol/L) and molar ratios Fe2+:H2O2 (1:1–1:10). Better results were obtained with 0.5 mmol Fe2+/L, and 1:10 ratio molar Fe2+:H2O2. Finally, UASB-Fenton coupled system allowed 80 % of COD decrease, almost complete removal of drugs and the toxicity of samples on Vibrio fischeri was reduced from 73 % to 30 %, demonstrating that this coupled system is a promising and efficient system for pharmaceutical compounds removal from wastewater. [ABSTRACT FROM AUTHOR]

Background: Psychoactive substance use is a public health challenge among young people in informal settlements. Though rarely examined, psychoactive substance use is linked to sexual expectancies and inhibitions, and consequently high-risk sexual behaviours. This study examined the association between sexual expectancies and inhibitions, and high-risk sexual behaviours among young psychoactive substance users (PSUs) in informal settlements in Kampala, Uganda.Methods: This cross-sectional study recruited 744 young PSUs from informal settlements in Kampala. Respondent driven sampling was used to recruit respondents. A 'modified' Poisson regression model was used for inferential statistics. Data were analysed using the Stata 14 software.Results: Of the 744 study participants, 45.6% believed that psychoactive substance use improves sexual performance; 43.3% believed that psychoactive substances make sex more pleasurable, and 53.3% believed that psychoactive substances give courage or confidence to approach a partner for sex. The belief that psychoactive substance use improves sexual performance (PR 1.14, 95% CI: 1.01-1.30), increases the likelihood of engaging in sex (PR 1.20, 95% CI: 1.04-1.40) or gives courage or confidence to approach a sexual partner (PR 1.21, 95% CI: 1.05-1.39) were associated with having sex while under the influence of psychoactive substances. The belief that a psychoactive substance user under the influence of psychoactive substances is more likely to engage in sex (PR 1.48, 95% CI: 1.15-1.90), and likely to find it difficult to refuse sex (PR 1.28, 95% CI: 1.06-1.55) were positively associated with engaging in multiple sexual partnerships. The belief that one easily forgets to use a condom when under the influence of psychoactive substances was positively associated with inconsistent condom use (PR 1.26, 95% CI: 1.09-1.45).Conclusion: Psychoactive substance use expectancies associated with high-risk sexual behaviours included the belief that psychoactive substances improve sexual performance and improve confidence in approaching a sexual partner. Psychoactive substance use inhibitions associated with high-risk sexual behaviours included an increased likelihood of engaging in sexual intercourse, difficulties in refusing to engage in sexual intercourse, and forgetting to use condoms while intoxicated. Interventions targeting a reduction in high-risk sexual behaviour should integrate the impact of psychoactive substance use on sexual behaviour. [ABSTRACT FROM AUTHOR]

Substance misuse is a major problem among individuals involved in forensic-correctional mental health services. Urine drug screening detects substance use and deters the entry of contraband into forensic-correctional units, albeit with limitations. For example, a point-of-care urine sample may not be possible and patients can alter or substitute samples to avoid detection, highlighting the role of ancillary tools to detect contraband substances. This study describes the pattern and types of substances detected from environmental samples using a gas chromatographic analyzer (TeknoScan TSI3000) in forensic-correctional populations to model the benefits of similar tools in similar settings. Samples collected over 18 months (January 2020 to June 2021) by trained staff members using the machine were reviewed. During this period, 217 environmental samples were recorded, and 66 (30%) samples were positive for contraband substances, including tetrahydrocannabinol (25%), methamphetamines (19%), and cocaine (16%). Other substances detected include methylene-dioxymethamphetamine, heroin, morphine, lysergic acid diethylamide, tramadol, and methyl-benzoate. Fewer positive samples were detected, especially during the time corresponding with the COVID-19 restriction on the forensic units. TeknoScan was beneficial as an ancillary tool to detect and deter contraband substances. It also provided evidence for risk management. Adequate training is needed for the successful implementation of the tool. • The impact of substance misuse on forensic-correctional inpatients (F-CIP) is huge. • Conventional methods of detecting substance misuse among F-CIP are limited. • TeknoScan was successfully used as an ancillary tool for drug screening among F-CIP. • TeknoScan has a promising role for drug screening in F-CIP but more research is needed. [ABSTRACT FROM AUTHOR]

Objective To conduct bibliometrics analysis of forensic toxicology literature of mainland Chinese scholars published in SCIE journals between 1998 and 2018. Methods Gephi 0.9.2 software was used for bibliometrics analysis. The status of forensic toxicology research in mainland China was network visualized through data analysis of institutional cooperation, author collaboration, fund support, keywords co-occurrence as well as literature interpretation. Results The total number of papers published in SCIE journals in the past twenty years by mainland Chinese scholars was 242, and increased year by year. Thematic studies, such as analysis and evaluation of toxins in hair, identification of new psychoactive substances, optical enantiomer analysis of amphetamines, analysis of toxic animal and plant components, etc, reached the international advanced level. Conclusion The forensic toxicology discipline in our country has developed rapidly in recent years. The opening and development of forensic science in colleges and universities, the constant emerging of new research teams, especially the funding of major special projects of National Natural Science Foundation of China and the Ministry of Science and Technology, have promoted high level research output and academic status of Chinese forensic toxicology on the international stage.

This paper focuses on the analysis of psychoactive substance use situation and preventive trends within communities of HE institutions in Lithuania. The researchers used a questionnaire, thus applying the quantitative research method. The research results: strong alcohol drinks among students of HE institutions are not popular; the respondents used psychoactive substances for the first time while still at secondary school; more than one tenth of the respondents indicated having driven a vehicle while under alcoholic intoxication at least once over the last 12 months. The alcohol, tobacco and other psychoactive substance use situation among students could be related to psychosocial factors: the possibility to relax, to reduce stress, to experience pleasure, to overcome boredom and to communicate. The results of the survey reveal an imperative to start a discussion about the formation and implementation of preventive measures against psychoactive substance use within communities of Lithuanian HE institutions.

Background: The widespread use of drugs in prisons leads to avoidable deaths, poorer health and a poor living environment. The contribution of psychoactive prescription drugs to this problem has received little attention in prison policy or at individual prescriber level. Aims: To determine the extent of unsafe and inappropriate prescribing of psychoactive medications in one UK prison using a newly developed medicines optimisation framework. Method: A medicines optimisation framework was developed based on principles of good prescribing. It was initiated on the opening of a new prison—HMP Berwyn—in February 2017. During the study period, all prisoners at HMP Berwyn were transferred from other prisons. The safety and appropriateness of psychoactive medications were evaluated de novo on reception at HMP Berwyn and during follow up, using the medicines optimisation framework. Results: About 1941 sentenced men arrived at HMP Berwyn between February 2017 and November 2018. Nearly one‐third (634, 33%) were on a prescribed psychoactive medication. Seventy‐five percent of these (474/634) required a prescription change due to appropriateness or safety concerns. Nearly half (295, 46.5%) received changes at reception despite having already undergone medicines reconciliation at their previous prison. Forty‐three percent (275/634) received changes at follow up, most commonly those who had no prior risks identified at reception. Conclusions: Inappropriate and unsafe prescribing of psychoactive medications is occurring in prisons despite mandatory medication reviews. Ongoing monitoring is required to reduce the risk from these medications. A medicines optimisation framework such as this could be adopted across other prisons, worldwide, to help contribute to risk reduction from drug use in prisons. Appropriately modified, a similar framework might help reduce inappropriate and harmful prescribing in hospitals and in the community. [ABSTRACT FROM AUTHOR]

Addictive drug use today is associated with the impact of the cultural configuration of consumer society and the transformation of institutions that leave young people in distress. Objective. To explore and to understand the subjectivity in the trajectory of the addictive consumption of Psychoactive Substances (PS). Method. Qualitative study from the Grounded Theory, with an intentional sampling, in which nine young people served in two Treatment Centers in Veracruz (Mexico) were interviewed, to reconstruct their Life Stories and their addictive trajectories, using the principle of saturation. Results. Six categories that marked subjectivity were identified: a) experiences within their family context, b) conditions of the social environment, c) what is looked for and what is found, d) filling inner emptiness with PS, e) Consumption related experiences and f) the trajectory of addictive consumption. Conclusions. The subjectivity present in the addictive consumption of PS implies a constant search for satisfaction to fill an emotional void. Studying subjective experiences in current addictive consumption, will allow a better understanding of the origin of addictive consumption and therefore, reorienting intervention strategies that consider the social conditions that produce it. [ABSTRACT FROM AUTHOR]

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ObjectiveThe present systematic review aims to analyze the evidence about the influence of placebo effect on craving and cognitive performance in alcohol, caffeine, and nicotine consumers.MethodsRelevant studies were identified via Pubmed, Web of Science, and Scopus databases (up to March 2020). Only those papers published between 2009 and 2019 were searched.ResultsOf the 115 preliminary papers, 8 studies of database search and 9 of the manual search were finally included in this review. Findings showed that while alcohol expectancies increased craving, caffeine and nicotine expectancies tend to decrease it. Alcohol expectancies caused similar or slower reaction time when alcohol was not consumed, impairments on inhibitory control (especially after alcohol consumption) and similar post-error slowing. The effect of caffeine and nicotine on reaction time has not been elucidated yet, however, caffeine expectancies have been shown to improve accuracy and the attentional filtering of distracting stimuli.ConclusionsAlcohol, caffeine, and nicotine expectancies play an important role on craving. Although expectancies produce an effect on cognitive performance, caffeine and nicotine beliefs show an ambiguous impact on reaction time. Only the influence of alcohol expectancies on reaction time has been clarified. Furthermore, caffeine beliefs enhance accuracy.

Objective: To track the trends and patterns of psychoactive substance abuse among medical students. Study Design: Cross-sectional questionnaire based study. Place and Duration of Study: Medical Colleges and Universities of Lahore, from Aug to Sep 2019. Methodology: Total 200 medical students from Medical Colleges and Universities were included. The data were analyzed and computed using SPSS-21. Frequencies and percentages related to all the factors were computed. Results: Among study participants, 96 (48%) of males and 104 (52%) of females with 154 (77%) of these students belong to 21-25 years of age group. The observed prevalence of substance abuse among students was 42 (21%). Joy seeking and a friend’s offer was the initiation of psychoactive substance use among these students. Tobacco was the most highly consumed substance among students, followed by marijuana. Besides, the results also revealed that students also consumed cocaine and methamphetamine. Among 21% abusers, 4 (9%) and 5 (11%) of the students experienced side effects and withdrawal symptoms respectively. Conclusion: The increasing consumption of tobacco and indulgence in psychoactive drugs are concerning issues because of uncontrolled consumption can cause serious brain damage. Academic burden and stress are the mediators of drug abuse among students. Therefore, stress management training and workshops should be conducted in institutes. [ABSTRACT FROM AUTHOR]

The use psychoactive substances are on the rise in general population and even seen more among those who are involved in criminal activities. There are many reasons for such irrational use of psychoactive substances. Objectives: To determine the prevalence and reasons of use of different psychoactive substances among prisoners at Malir prison, Karachi. Study Design: Descriptive Cross-Sectional study. Setting: Malir prison, Karachi. Period: 22nd April 2019 to 26th May 2019. Material & Methods: This study was conducted at district Malir prison, Karachi. All the cases who were imprisoned due to any reason and had history of psychoactive substance use were enrolled. Thorough history and examination was carried out. Ethical considerations were taken as per international guidelines. Results: Among all 490 male prisoners who used to take different type of psychoactive substance, majority were of age ranges of 21 to 35 years and 55% were married while 44% were single and 1% were divorced or separated. Out of 490 cases 453 (92%) were using different substances thorough routes other than injections while 37 (8%) were injection users. Majority of prisoners 252 (52%) were using Heroin while 86 (17%) were using Crystals, 74 (15%) Cannabis, 37 (8%) Synthetic substances, 24 (5%) Ice, 6 (1%) Opioid and 11 (2%) were using some other type of substance. The most common reason of substance use was peer pressure followed by fun and frustration. Conclusion: Substance use prevalence is high in prison. Existing services for the management of drug dependence are not meeting the global standard of evidence based comprehensive drug treatment and rehabilitation. [ABSTRACT FROM AUTHOR]

Purpose: We aimed to determine the relationship between psychoactive substance (PAS) use and sociodemographic and clinical characteristics in patients with psychotic disorders in a regional mental health and disease hospital. Materials and Methods: We included 110 inpatients diagnosed with psychotic disorders according to DSM-5 criteria. We investigated clinical records to determine the patients' sociodemographic data and characteristics, such as smoking, alcohol, use of PAS, number of hospitalizations, duration of the disorder and last hospitalization, suicide attempts, and attempted harm to others. We also investigated whether the medical staff applied physical restraints during the hospitalization and the presence of legal problems. Results: Thirty-four (30.9%) of 110 patients with a psychotic disorder were using psychoactive substances. The preferred substances were 17.3% cannabis, 7.3% amphetamine, 0.9% cocaine, 0.9% heroin, 2.7% inhaler, respectively. We found that the PAS users differed from not users with age, the number of antipsychotics used, the rate of restraints, legal problems, alcohol and smoking, and homicide attempts. Conclusion: Comorbidity of substance use in psychotic disorders is seen at rates that cannot be underestimated. The results obtained such as using more antipsychotic combinations in patients using psychoactive substances, application of more detection during hospitalization, homocidal intervention and high legal problem history support that substance use makes the follow-up and treatment of patients diagnosed with psychotic disorders difficult. [ABSTRACT FROM AUTHOR]

Objective: The present systematic review aims to analyze the evidence about the influence of placebo effect on craving and cognitive performance in alcohol, caffeine, and nicotine consumers. Methods: Relevant studies were identified via Pubmed, Web of Science, and Scopus databases (up to March 2020). Only those papers published between 2009 and 2019 were searched. Results: Of the 115 preliminary papers, 8 studies of database search and 9 of the manual search were finally included in this review. Findings showed that while alcohol expectancies increased craving, caffeine and nicotine expectancies tend to decrease it. Alcohol expectancies caused similar or slower reaction time when alcohol was not consumed, impairments on inhibitory control (especially after alcohol consumption) and similar post-error slowing. The effect of caffeine and nicotine on reaction time has not been elucidated yet, however, caffeine expectancies have been shown to improve accuracy and the attentional filtering of distracting stimuli. Conclusions: Alcohol, caffeine, and nicotine expectancies play an important role on craving. Although expectancies produce an effect on cognitive performance, caffeine and nicotine beliefs show an ambiguous impact on reaction time. Only the influence of alcohol expectancies on reaction time has been clarified. Furthermore, caffeine beliefs enhance accuracy. [ABSTRACT FROM AUTHOR]

Introduction: Substance abuse refers to the harmful or hazardous use of any psychoactive substance including licit and illicit drugs, other than when medically indicated. According to a UN report, 1 million heroin addicts are registered in India, and unofficially, there are as many as 5 million. Among all the states Punjab stood third in substance abuse and also injectable drug use. The present study was thus conducted to assess the sociodemographic profile and pattern of substance abuse among patients attending a Drug de-addiction centre. Material and Methods: A record-based analysis from March 2015 to March 2019 was done. Substance dependence was diagnosed post detailed clinical interview by a consultant psychiatrist at the center using DSM -10. For the 966 registered patients admitted in the last four years, the record was checked for completeness of data and relevant information on socio-demographic profile, substance abused, duration of hospital stays, drop out and relapse rates was extracted. Results: Of the total admitted patients (n= 966) 100% addicts were of male gender and natives of Punjab. 514 (53.21%) were married followed by 434(44.93%) never married. Maximum patients 456(47.20%) were self-employed. Heroin was the most abused drug. The injecting route of drug abuse was used by most of the abusers i.e. 51.66%. Only 173 (17.90%) patients dropped out of the treatment followed by relapse in 192 (19.88%). Conclusion: In this paper we demonstrated the vulnerability of young population towards drug addiction. Easy accessibility of drugs, peer pressure and difficult family circumstances raises the fragility to restore for substance use. However, community-based studies are imperative in order to estimate how big is the problem at the bottom. [ABSTRACT FROM AUTHOR]