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Purpose: Healthcare professionals (HCPs) play a critical role in suicide prevention and clinical guidelines recommend inquiring about suicidality as part of medical history and diagnosis. Emerging evidence indicates a lack of implementation of such policies in clinical practice. However, to date, no comprehensive mixed-methods study has examined this issue in the field of oncology. Methods: A preregistered mixed-methods study was conducted with oncological HCPs (N = 20) from various professions, using semi-structured interviews and validated questionnaires. Employing an explorative theory-generating approach, qualitative content analysis was applied to the interviews. The different data sources are integrated and contrasted. Comparisons according to sociodemographic variables (profession, age, and gender) and frequency distributions were used to examine the questionnaire data. Results: Most HCPs reported direct or indirect experiences with suicidality in cancer patients. Nineteen HCPs did not routinely explore suicidality, of whom five reported not inquiring about it at all. Those who explored suicidality were more confident, less emotionally overwhelmed and reported higher subjective knowledge. HCPs also differed regarding their endorsement of suicide myths. Conclusion: The study highlights difficulties with active suicide exploration and differences among HCPs. Integrating these findings into education and training could improve HCPs’ skills and reduce disparities, supporting successful suicide prevention.Highlights: Mixed-Methods study on suicide prevention from oncology experts’ perspective. Experts experience different manifestations of suicidality in cancer patients. Recommendations to actively explore suicidality are not adequately followed. Differences in knowledge, confidence, and stigmatization. Common, but also diverging agreement with suicide myths. [ABSTRACT FROM AUTHOR]

Background: People with Stage IV cancer face physical and emotional challenges impacting quality of life. Conventional quality of life measures do not capture daily fluctuations in patient well-being. Aim: This pilot study used daily diaries to explore the concept of a "good day" living with advanced cancer and to identify activities associated with "good days" as well as associations between daily "goodness" and conventional quality of life measures. Design: Twenty participants with Stage IV cancer completed daily diaries on a mobile app over a 14-day period. Participants rated each day's "goodness" and documented daily activities. Statistical analyses examined associations between daily "goodness" ratings, activities, and baseline quality of life measures from the Patient-Reported Outcomes Measurement Information System (PROMIS). Setting/participants: Participants were recruited from oncology clinics and online research registries. Inclusion criteria included age over 18 years old, having Stage IV cancer, and owning a smartphone. Results: Analysis of 178 completed surveys from 18 participants revealed overall average "goodness" ratings exhibited more within-person than between-person variability. Average goodness was positively related to the PROMIS domain of Ability to Participate in Social Roles/Activities and negatively related to PROMIS domains of Anxiety and Depression. Participants reported better days when they engaged in leisure activities and worse days when they spent time managing physical symptoms. Conclusions: This study highlights the importance of understanding day-to-day quality of life in individuals with advanced cancer. Further research is needed to assess quality of life longitudinally and to develop personalized supportive and palliative care interventions in this population. [ABSTRACT FROM AUTHOR]

Simple Summary: This study explores how personality traits influence the quality of life (QoL) in patients with high-grade malignant brain tumors undergoing radiotherapy (RT). By assessing traits such as neuroticism, extraversion, and anxiety, alongside QoL indicators, this research identifies how psychological profiles shape emotional, cognitive, and social outcomes during and after treatment. Understanding these relationships can help healthcare professionals personalize supportive care strategies, ultimately improving patient well-being and treatment experiences. The findings emphasize the need for integrating psychological assessments into routine oncology care, offering practical guidance to enhance holistic cancer management and potentially influencing future research on psycho-oncological interventions. Background: Understanding the role of personality traits in shaping treatment outcomes is crucial given the multifaceted challenges posed by brain tumors and the significant adverse impact of radiotherapy (RT) on patients' well-being. Purpose: This study aimed to provide insights into how personality traits affect psychosocial well-being and quality of life during RT in patients with high-grade malignant brain tumors. Methods: Personality traits in patients with high-grade glioma were assessed using the Eysenck Personality Questionnaire-Revised (EPQ-R). Quality of life was analyzed using EORTC questionnaires: the Questionnaire-Core 30 (QLQ-C30) and the Brain Cancer Module (QLQ-BN20). Patients were evaluated before RT, immediately after 6 weeks of RT, and 3 months post-RT. Results: Neuroticism predicted emotional function only three months post-RT. Extraversion decreased quality of life in global health status (third assessment), role function (second assessment), and emotional function (second and third assessments) but improved cognitive (first assessment) and social function (second assessment). The trait associated with lying was linked to a better quality of life in all domains except physical and cognitive function. Anxiety predicted a lower quality of life in brain tumor patients across all domains at various stages of RT treatment. Conclusions: This study advances our understanding of the psychosocial aspects of brain tumor care by highlighting the influence of personality traits on quality-of-life outcomes during RT. Identifying high-grade glioma patients at greater risk of a diminished quality of life based on personality profiles allows healthcare professionals to tailor interventions to address specific psychosocial needs, ultimately enhancing patient outcomes and holistic care during oncological treatment. [ABSTRACT FROM AUTHOR]

Background: The diagnosis and treatment of cancer are associated with substantial physical, psychological, and social morbidity for most patients. Distress can be seen as an unpleasant experience of an emotional, psychological, social, or spiritual nature that interferes with the ability to cope with cancer treatment. Purpose: The aim was to understand patients' experiences of distress in their context and to analyze and interpret the findings. Method: An explorative, descriptive qualitative study was conducted among cancer patients receiving treatment and care at rural hospitals in Limpopo. A face-to-face individual interview was conducted to determine the participants' cancer-related experiences and quality of life. Thematic analysis was conducted following Tesch's method, and the themes developed were subjected to a triangulation process to ensure the validity and rigor of the findings. Findings: The participants revealed experiences of symptomatic distress resulting in biopsychosocial distress such as pain, fatigue, emotional distress related to prognosis and uncertainty about the future, psychosocial distress related to a lack or absence of support, financial instability, and poor self-esteem. Conclusions: Cancer patients face many challenges during their treatment journey. Participants were drained by anxiety and uncertainty of the cancer trajectory and required psychosocial support. The oncology team must provide supportive preventive measures for side effects management and culture-sensitive psychotherapy at an early stage to improve their quality of life. [ABSTRACT FROM AUTHOR]

Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project's distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome. [ABSTRACT FROM AUTHOR]

Background: One third of adults with cancer suffer from common mental disorders in addition to their malignant disease. However, it is unknown whether this proportion is the same in patients who have brain tumors and which factors modulate the risk for psychiatric comorbidity. Methods: In a multicenter study, patients with high‐grade glioma at 13 neurooncology clinics were enrolled consecutively and interviewed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders (SCID) to diagnose common mental disorders. Predictors of psychiatric comorbidity were investigated using binary logistic regression. Results: Six hundred ninety‐one patients were interviewed. The proportion of patients who had mental disorders was 31% (95% confidence interval [CI], 28%–35%). There was evidence for an association of psychiatric comorbidity with the following factors: younger age (odds ratio [OR], 1.9; 95% CI, 1.1–3.4; p =.04), stable disease versus complete remission (OR, 1.7; 95% CI, 1.1–2.8; p =.04), lower income (OR, 1.7; 95% CI, 1.0–2.8; p =.04), living alone (OR, 1.6; 95% CI, 1.0–2.6; p =.05), fatigue (OR, 1.6; 95% CI, 1.1–2.4; p =.03), and impaired cognitive functioning (OR, 2.3; 95% CI, 1.5–3.6; p <.01). There was no evidence for independent effects of gender, histology, affected lobe, time since diagnosis, or employment status. Conclusions: Approximately one third of adult patients with high‐grade glioma may suffer from a clinically relevant common mental disorder, without notable disparity between the genders. In particular, clinicians should pay attention to possible comorbidities for cases in which patients exhibit compromised subjective cognitive function, are younger than 50 years, maintain a state of stable disease, or live alone. In a multicenter, cluster‐randomized clinical trial involving 691 adult patients with high‐grade glioma, the proportion with a comorbid psychiatric disorder was 31%. Comorbidity was more likely in younger patients and in those who had stable disease, were living alone, had lower income, had impaired subjective cognitive functioning, and had fatigue. [ABSTRACT FROM AUTHOR]

Purpose: A high incidence of psychosocial problems in prostate cancer patients has been reported including anxiety, depression and distress. These can add to the patients’ disease burden and have been associated with unfavorable cancer treatment outcomes. Interventions designed to address them have found limited success, but psychological resilience (PR) training has never been formally tested. The measurement of PR in prostate cancer patients has been described and has been associated with more favorable psychosocial outcomes in these patients but it has never been systematically reviewed. The aim of this study was to conduct the first systematic review of those studies that have measured it using standardized scales and to determine the potential for resilience training to help overcome the significant psychosocial problems faced by prostate cancer patients. Materials and Methods: We searched the literature to identify articles that measured PR among prostate cancer patients. Results: Of 384 articles identified by the search criteria, there were 19 studies suitable for inclusion regarding 5,417 patients. The most commonly-used scale was the original Connor-Davidson Resilience Scale, or an abbreviated version of it. Possible scores range from 0 to 100, mean scores from these studies ranged from 72.9 to 87.1 (standard deviations varied between 13.2 and 16.3). PR was consistently associated with improved psychological outcomes including depression, anxiety and distress, although these were measured with a wide variety of methods making it difficult to quantify the effects. There was also evidence of PR mediating the physical effects of prostate cancer and treatment including urinary symptoms, fatigue and insomnia. Conclusions: As resilience training has been successful in other cancer settings, it seems likely that it could improve the significant adverse psychosocial outcomes that have been reported in prostate cancer patients and trials designed to objectively test it should be encouraged. [ABSTRACT FROM AUTHOR]

The present study aimed at understanding, through the construction of a substantive theory encompassing the experience of the losses lived by Venezuelan cancer survivors. The study was qualitative, under the emerging and projected grounded theory designs. Ten surviving cancer patients, men, and women of different ages and diagnoses, participated. We collected the information through in-depth interviews. For the analysis of data we applied the method of constant comparisons. Surviving patients experienced different losses that are not limited to health-related ones. Emotional discomfort, acceptance, and resignification delineated the experience of loss in survivors. Acceptance, promoted by optimism, hope, and social/family support, facilitated adjustment to everyday life, management of fear of cancer recurrence, guilt, and resignification of cancer and its losses. The study revealed psychosocial resources that promote adaptation to loss during cancer survival. [ABSTRACT FROM AUTHOR]

The article explores the characteristics of prostate cancer patients seeking integrative medicine at an academic cancer center. The study found that patients sought integrative oncology services primarily for guidance on diet and nutrition, counseling on herbs and supplements, and specific integrative therapies like acupuncture. Common symptoms reported included fatigue, hot flashes, and trouble sleeping. The study highlights the need for further research to address the needs of this patient population and improve coordination of integrative services with traditional cancer care. [Extracted from the article]

Background: Nasopharyngeal carcinoma (NPC) patients often face significant physical and psychological challenges. While disease control remains a clinical priority, the impact on distress and health-related quality of life (HRQOL) is often overlooked. This study will assess distress and the HRQOL prevalence, severity, and relationship among post-treatment nasopharyngeal carcinoma (NPC) patients and investigate its associated factors. Method: A cross-sectional study at Hospital Melaka (HM) and Hospital Canselor Tuanku Muhriz (HCTM) involved post-treatment NPC patients with at least six months of follow-up. Distress was assessed using the Distress Thermometer (DT). Quality of life (QoL) and symptomatology were assessed with the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) and EORTC Head and Neck Module (QLQ-H&N 35). We conducted statistical analyses using Kruskal–Wallis and Mann–Whitney U tests for comparisons and Spearman Correlation for analyzing relationships. Results: One hundred forty-four patients with a median age of 60.5 years (range 18–92) were recruited and completed the questionnaires. The median NPC surveillance follow-up time was seven years (6 months to 36 years). 84% of the patients received concurrent chemoradiotherapy. The majority of the patients were in late stage 57.6% (Stage III, n = 51[35.4%]; Stage IV, n = 32 [22.2%]). The median distress score is 4 (range, 1–8), and the median HRQOL score is 75 (range of 50–100). A significant negative correlation was found between distress and the HRQOL score. (r = -0.53, p < 0.01). Factors influencing distress and HRQOL scores were sticky saliva, dry mouth, fatigue, and less sexuality, with a significance of P < 0.01. Conclusion: Overall distress and HRQOL scores among post-treatment NPC patients were good. Factors such as sticky saliva, dry mouth, fatigue, and decreased sexuality substantially impacted distress and HRQOL. Addressing these factors alongside cancer treatment may enhance HRQOL outcomes. [ABSTRACT FROM AUTHOR]

Objective: This study aims to investigate the psychological distress and its influencing factors in patients with biliary tract malignant tumors, alongside the development of a predictive model. Methods: A total of 219 patients diagnosed with biliary tract malignant tumors who were admitted to the Department of Liver Surgery at Fudan University Shanghai Cancer Center from July 2021 to May 2023, were selected using a convenience sampling method. Research tools involve psychological distress management screening tools, a demographic questionnaire, self-rating anxiety and depression scales, and the Chinese version of the Memorial Symptom Assessment Scale. Bootstrap method was utilized for repeated sampling to identify relevant factors influencing psychological distress in biliary tract cancer patients. The R software was employed to create a nomogram model, and the model's accuracy and predictive performance were assessed using the receiver operating characteristic curve (ROC) and the Hosmer-Lemeshow test. Results: The average score of psychological distress among the 219 patients was (3.91 ± 2.44), with a psychological distress detection rate of 54.8%. Regression model results indicated that factors such as the presence of distant metastasis, comorbidity with other major diseases, poor sleep quality, anxiety, and severity of anxiety and depression were the primary influencers of psychological distress. Conclusion: The detection rate of psychological distress in patients with biliary tract malignant tumors is notably high. The predictive model constructed in this study exhibits good predictive efficacy and clinical value, providing valuable reference for healthcare professionals in developing targeted intervention strategies. [ABSTRACT FROM AUTHOR]

Background: Psychological distress impacts 35–40% of cancer patients, significantly affecting their quality of life, treatment adherence, and relationships with healthcare professionals. Given this, there is a critical need to enhance nursing competencies to effectively monitor and address psychological distress. Previous studies have highlighted discrepancies in capabilities based on nurses' training status, emphasizing trained nurses' critical role in providing appropriate psycho–social referrals. Objective: To evaluate the impact that trained nurses have on the detection of distress and the timely referral of patients for a psycho–oncology consultation. Methods: A blinded, random, descriptive, monocentric pilot study was conducted. The participants were adult patients in Day Hospital 1 of the National Cancer Institute Regina Elena, Rome, irrespective of illness stage. Tools used included a socio-demographic and clinical data form, distress thermometer (DT), and visual analogic scale (VAS). Patients were randomly divided into two groups: Group A, where questionnaires were administered by trained nurses, and Group B, where non-trained nurses administered questionnaires. Nurses indicated whether patients needed a psycho–oncology consultation. All patients were then seen by a psycho–oncology specialist to determine whether the nurse's referral was appropriate. Patients and psycho–oncologists were all unaware of the nurses' training status. The effectiveness of the training was measured by the degree of agreement between evaluators. Results: This study involved 20 patients and four nurses. The average DT score was 5, mainly related to physical and emotional problems. Agreement between evaluators was higher in the trained nurses' group. Conclusions: Specific training on DT enabled nurses to acquire advanced skills to accurately refer patients for psychological consultations. [ABSTRACT FROM AUTHOR]

BackgroundMethodsResultsConclusionsTo better understand informal coping strategies among adolescents and young adults (AYAs) with cancer, the current investigation asked AYA study participants to describe the ‘advice’ they would offer to hypothetical peers about coping following diagnosis. This study explores the utility of the single item ‘advice’ prompt for supportive oncology research and practice.AYA cancer patients (n = 27) aged 12–25 years were recruited through electronic health record query at a single-institution health system. Participants completed semi-structured interviews. Inductive themes were described regarding advice about informal coping strategies following cancer diagnosis. The Institutional Review Board approved this study (HUM#00157267).Emergent advice themes included (1) attitude re/framing, (2) engage support network, and (3) self-advocacy. Participants advised cultivating a positive yet realistic attitude about the present and future. Reaching out to support network members and accepting help were advised, as was rebuffing unhelpful support. Participants also advocated for addressing medical information needs and building trusting relationships with clinicians.Soliciting AYA advice serves to identify informal coping mechanisms in response to life-stage-specific concerns. Future research is called to substantiate the utility of ‘advice’ as a single item tool for research and clinical questionnaires. Practice implications call for creating opportunities for AYAs to impart their advice to others (e.g. anonymous community message board) as a means of personal catharsis, altruistic service, and legitimizing AYAs as ‘embodied’ experts of their own experiences. [ABSTRACT FROM AUTHOR]

Purpose: The development of brain metastases (BM) can significantly increase the psycho-oncological burden in cancer patients, requiring timely intervention. In addition, this aspect may negatively affect the course of the disease and treatment outcome. However, screening for psycho-oncological burden is often overlooked in clinical routine. Therefore, we analyzed the extent of psycho-oncological distress in a patient population with BM receiving neurosurgical resection and identified clinical characteristics associated with a high need for psycho-oncological intervention. Methods: We prospectively screened 353 patients (169 female, 184 male, mean age 61.9 years) scheduled for microsurgical resection of one or more BM. Psycho-oncological screening was performed on the day of admission using the Hornheider screening instrument (HSI) and the distress thermometer (DT). Screening results were correlated with demographic and clinical data. Results: Most patients (73.1%) completed the screening questionnaire. Patients who failed to complete the questionnaire presented more frequently with metachronous BM (74.7% vs. 25.3%, p=0.009), were significantly older (p=0.0018), and had a significantly lower KPS score (p=0.0002). Based on the threshold values of the questionnaires, 59.3% of the patients showed a significant psycho-oncological burden requiring immediate intervention. Univariate analysis demonstrated that synchronous BM (p=0.034), tumors in eloquent areas (p=0.001), lower KPS (p=0.031), female gender (p=0.009), and presurgical aphasia (p=0.042) were significantly associated with high psycho-oncological burden. Multivariate analysis showed synchronous BM (p=0.045), female gender (p=0.005), and lower KPS (p=0.028) as independent factors associated with high psycho-oncological burden. Conclusion: The majority of patients with BM have a high psycho-oncological burden. Female gender, synchronous BM, and lower KPS are independently associated with a need for psycho-oncological intervention. [ABSTRACT FROM AUTHOR]

Background: Gliomas, the most common primary brain tumours, are classified based on histology and molecular genetics. Glioblastomas (GBM) are highly aggressive and are graded as WHO grade 4, while astrocytoma and oligodendrogliomas fall under WHO grades 2-3 (4). Gliomas affect 6 per 100,000 people, with a higher incidence in men. GBM has the poorest prognosis, whereas grade 2 astrocytoma and oligodendrogliomas show better outcomes. Quality of life (QoL) is now a crucial therapeutic goal alongside survival. Despite the impact of gliomas on QoL, especially given their incurability and progressive neurological deficits, research specifically comparing QoL and psycho-oncological stress in GBM versus grade 2 gliomas (glioma_2) remains limited. This study aims to fill that gap using validated measurement methods. Methods: This retrospective, single-centre study investigated differences in QoL among neuro-oncological patients using the Karnofsky Performance Score (KPS), Distress Thermometer (DT), Hospital Anxiety and Depression Scale (HADS), and EORTC-QLQ-C30-BN20. Data were collected before chemotherapy or radiotherapy to avoid therapy impact on QoL. Out of 2258 patients screened until June 30, 2022, 639 had glioblastoma or WHO grade 2 gliomas, with 223 meeting inclusion criteria for analysis. Results: The study included 161 GBM and 62 Glioma_2 patients, with 64% of all patients being male. The mean age was 58.11 years (SD ± 16.186). The DT did not show significant differences between GBM and glioma_2 glioma patients (median GBM:6 vs. 5 in glioma_2, p=0.480). However, the HADS-D indicates that GBM patients experience significantly more depression (median GBM 4.5 vs. 4 in glioma_2, p=0.033), though anxiety levels are similar in both groups (median GBM. 6 vs. 6 in glioma_2, p=0.867). The KPS (median GBM 70 vs. 90 in glioma_2, p<0.001) and specific aspects of the EORTC-QLQ-C30-BN20 questionnaire demonstrate that GBM patients have notably greater physical impairments than glioma_2 patients at diagnosis. Overall, GBM patients report worse quality of life compared to glioma_2 patients (median GBM 50 vs. 67 in glioma_2, p<0.001). Conclusion: This study showed that distress is present in glioma patients regardless of their histopathological grading, even though GBM patients show higher depression levels and more physical limitations. Targeted anxiety management and early depression screening are essential for all glioma patients. Early QoL screening and making QoL a therapeutic goal benefits patient care and society. [ABSTRACT FROM AUTHOR]

Objective: The diagnosis of a mood‐related psychiatric disorder (MRPD) among patients with cancer has been associated with decreased quality of life and lower cancer survival. This study aimed to understand the risk of a new MRPD after cancer diagnosis by individual risk behaviors, with a specific focus on tobacco use and the presence of a human papillomavirus (HPV)‐associated cancer. Methods: Single‐center retrospective cohort study of 11,712 patients diagnosed with cancer between 2009 and 2020. We identified predictors of a new MRPD after cancer diagnosis using a time‐to‐event analysis and Cox proportional hazards model including demographics, disease characteristics, and tobacco use and HPV‐associated tumors. Results: Univariate analyses revealed lower hazard ratios (HRs) of a new MRPD among individuals that identified as Asian/Pacific Islanders and among the older age groups (> 51 years). Univariate analyses additionally demonstrated higher HRs of MRPD among females; sexual minorities; former and current smokers; individuals with HPV‐associated cancers; and individuals diagnosed at later stages. These relationships were observed in the multivariate model when adjusting for covariates. Shorter time‐to‐MRPD was observed when stratifying by individual behavioral risk factors, with active smokers and individuals with an HPV‐associated cancer being at the highest risk. Conclusions: Individual behavioral risk factors increase risk of new MRPD after being diagnosed with cancer. These findings build on past studies by linking tobacco use and HPV‐associated cancers with MRPD risk in oncology and can be used to identify patients at risk of developing new MRPDs post‐cancer diagnosis and engaging them in treatment. [ABSTRACT FROM AUTHOR]

Taste disturbances are prominent side effects of antineoplastic medications and contribute to morbidity and quality‐of‐life impairment. Few treatment options are available for antineoplastic‐related taste disorders. Hypnosis has been found to be effective for a variety of symptoms in the cancer setting, including insomnia, pain, mood disorders and anxiety. Numerous somatosensory perceptual changes have been observed with hypnosis, including perception of tactile stimuli and color. Here, we report a case of a 74‐year‐old woman with recurrent metastatic breast cancer presenting with an 18‐month history of antineoplastic‐related hypogeusia. She was treated with hypnosis and reported resolution of taste symptoms after 10 days of daily practice. Her improvement seems to be related to hypnotic changes in somatosensory perception, which may be associated with functional alterations in salience, executive control and default mode networks during hypnosis. Further investigation of hypnosis for antineoplastic‐related taste disturbances is indicated. [ABSTRACT FROM AUTHOR]

Objective: The Worries About Recurrence or Progression Scale (WARPS) was recently validated in four common chronic illnesses other than cancer, after a rigorous development process based on the COSMIN criteria. Available measures of fear of progression or fear of cancer recurrence (FCR) have been criticised for not meeting all COSMIN criteria. Therefore, this study aimed to explore the psychometric properties of the WARPS in a cancer sample to assess its applicability to measure FCR. Methods: We recruited 346 participants living with or beyond cancer for an online survey. The psychometric properties of the WARPS were examined using a confirmatory factor analysis. Convergent validity was assessed against the current gold standard questionnaires and constructs related to FCR. Some participants completed a follow‐up survey 2 weeks later, to assess the test‐retest reliability. Finally, a Receiver Operating Characteristics analysis was conducted to determine clinical cut‐offs for the WARPS. Results: Confirmatory factor analysis confirmed that the WARPS has one underlying factor, fear of recurrence or progression (FRP), with adequate model fit. The WARPS demonstrated excellent internal consistency, test‐retest reliability and showed convergent validity. ROC analysis revealed a cut‐off of 54 for moderate, and 65 for severe FCR on the WARPS. Conclusions: The WARPS demonstrated good psychometric properties in a cancer sample. It has the capacity to be used as a screening tool to identify clinical levels of FCR. The WARPS was developed consistent with the COSMIN criteria and overcomes some of the limitations of existing measures. [ABSTRACT FROM AUTHOR]

Objective: To identify the feasibility, acceptability, and effectiveness of web‐based acceptance and commitment therapy (ACT) on health‐related outcomes in patients with lung cancer. Methods: A feasibility, prospective, parallel, individual‐based, assessor‐blinded randomized controlled trial was designed. This study was conducted at a third‐level hospital in Sichuan Province, China. A total of 101 participants were enrolled and randomly assigned to usual care group or 7‐weekly web‐based acceptance and commitment therapy group. The primary outcome was feasibility and acceptability of the intervention, and the secondary outcomes including quality of life, psychological flexibility, anxiety, depression, fatigue, and sleep disturbance. Generalized estimating equations were used to evaluate the group differences. All analyses followed the principle of intention‐to‐treat. Results: Web‐based ACT presented good feasibility and acceptability in this study, with an attrition rate of 13.86%, a median compliance rate of 71.43%, and a satisfaction rate of 65.9%. Compared with control group, participants in intervention group reported statistically significant increases in quality of life (MD = 15.10, 95% CI: [10.09, 20.11], d = 0.37), psychological flexibility (MD = −8.42, 95% CI: [−10.81, −6.03], d = −1.47), anxiety (MD = −1.27, 95% CI: [−2.50, −0.05], d = −0.44), depression (MD = −2.11, 95% CI: [−3.28, −0.95], d = −0.76), and sleep disturbance (MD = −1.85, 95% CI: [−3.10, −0.59], d = 0.13) at postintervention, however, the improvement in fatigue was not statistically significant (MD = −2.02, 95% CI: [−9.02, 4.98], d = −0.12). Conclusions: Web‐based ACT was an approach with good feasibility and acceptability, and it could effectively improve quality of life, psychological flexibility, anxiety, depression, and sleep disturbance in patients with lung cancer. In order to achieve better results, there is a need to design a more tailored intervention plan and a more operational platform. [ABSTRACT FROM AUTHOR]

Background: Patients' sociodemographic factors, clinical characteristics, distress factors, perceived shame and stigma may give rise to psychological distress in cancer patients that bring about further psychosocial impact. Aims: (1) to determine the degrees of shame and stigma towards cancer and psychological distress among cancer patients in Malaysia and (2) to examine the clinical and psychosocial predictors of psychological distress. Methods: This cross‐sectional study recruited a total of 217 cancer patients. The participants were administered the sociodemographic and clinical characteristics questionnaires, the Malay version of the Shame and Stigma Scale (SSS‐M) to assess for the degree of cancer shame and stigma, and the Malay version of the Distress Thermometer and Problem List to assess for presence of psychological distress and identify its sources. Results: There was a significant level of shame and stigma among cancer patients with the total mean SSS‐M score of 12.08 (SD = 6.09). Anger (adjusted odds ratio [AOR] = 11.97, 95% confidence interval [CI] = 2.96–86.8, p = 0.001), loss of interest or enjoyment (AOR = 14.84, 95% CI = 2.93–75.20, p = 0.001), loneliness (AOR = 8.10, 95% CI = 1.13–58.02, p = 0.001), feeling of worthlessness or being a burden (AOR = 6.24, 95% CI = 1.32–29.59, p = 0.021), fear (AOR = 4.52, 95% CI = 1.79–11.43, p = 0.001), pain (AOR = 4.07, 95% CI = 1.53–10.82, p = 0.005), financial constraint (AOR = 2.95, 95% CI = 1.22–7.13, p = 0.016), and having regret (AOR = 1.89, 95% CI = 1.03–3.79, p = 0.039) increased the odds of developing psychological distress. Conclusion: Treating clinicians should monitor for and provide psychosocial interventions for the biopsychosocial factors which may worsen psychological distress among cancer patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effectiveness of the Melanoma Care Programme when implemented into routine clinical practice coupled with fear of cancer recurrence (FCR) screening and a stepped‐care model of intervention delivery. Methods: Using a Type‐I hybrid effectiveness‐implementation design, individuals with stage 0‐II melanoma and a Fear of Cancer Recurrence Inventory FCR severity score of ≥ 13 were offered the Melanoma Care Programme. The programme included a psychoeducational booklet and 3 to 5 psychotherapeutic telehealth sessions with a clinical psychologist, timed around routine dermatological appointments. Multivariable linear mixed modelling was used to analyse the effect of the intervention at 1‐week post‐intervention on patient‐reported outcomes, including FCR severity (primary outcome), symptoms of depression, anxiety, and stress, melanoma‐related knowledge, and health‐related quality of life. Results: One hundred and twelve participants completed the intervention from 146 participants screened for FCR. Adjusted multivariable linear mixed modelling demonstrated that participants who received the intervention reported a reduced FCR severity at 1‐week post‐intervention (mean change: −3.81 [95% CI: −4.67, −2.95], p < 0.001) compared to baseline. Participants also reported improvements in melanoma‐related knowledge (mean change: 0.64 [95% CI: 0.13, 1.15], p = 0.014), depressive symptoms (mean change: −1.41 [95% CI: −1.92, −0.90], p < 0.001), anxiety (mean change: −1.05 [95% CI: −1.48, −0.61], p < 0.001), stress (mean change: −1.58 [95% CI: −2.22, −0.93], p < 0.001), and health‐related quality of life (mean change: 4.05 [95% CI: 2.84, 5.26], p < 0.001). Conclusions: The Melanoma Care Programme maintained effectiveness when implemented into routine clinical practice with the addition of FCR screening and a stepped care model of delivery. Trial Registration: This study is registered with the Australia and New Zealand Clinical Trials Register (ACTRN12621000145808) [ABSTRACT FROM AUTHOR]

Background: Providing supportive services to patients and their caregivers is essential to quality cancer care, yet the depth, availability, and infrastructure underlying these services remains unknown in community practice. We assessed these factors among practices within the National Cancer Institute Community Oncology Research Program (NCORP) to guide priorities for comprehensive supportive service(s) development and inform implementation of evidence‐based interventions in clinical practice. Methods: Supportive care leaders at NCORP practices completed online surveys regarding availability of services to patients and caregivers within seven domains, service infrastructure (e.g., staffing, technology), and implementation recommendations for caregiver‐specific services. Primary outcomes were the proportion of practices offering at least one service in each domain to both populations and the proportion offering caregiver training/education. Results: Of the 103 participating practice groups, only 15.5% offered at least one service in each domain to both populations; 21.4% offered caregiver training/education. Psychological (83.5%) and spiritual/religious (75.7%) services were most widely available to both; health promotion (28.2%) services were least available to both. Services offered were largely available on‐site with dedicated staff; caregiver‐specific services were nearly always off‐site and typically self‐pay. Practices most often used the patient health portal to communicate with patients and caregivers (54.4%). Only 28.9% provided bilingual staff for services. Social workers (35.7%) and navigators (34.7%) were recommended to support caregiver services. Conclusions: To meet national recommendations for supportive service provision, practices should invest in caregiver education/training programs, expand health promotion programs, and increase interpretation services. Future interventions should leverage existing resources (e.g., recommended staff, patient portal). [ABSTRACT FROM AUTHOR]

Background: Spiritual care is a key domain of quality palliative care as defined by national palliative care guidelines. Aims: The aim of this project was to synthesize data and research experience by the authors over 30 years related to spirituality in patients with cancer. The research objectives for this analysis were to:Describe spirituality in patients with cancer.Determine the outcomes of palliative care interventions on spirituality and related variables in patients with cancer in these studies conducted by the authors.Summarize methodological issues in conducting research related to spirituality in oncology patients. Methods: A synthesis of 15 prior studies conducted by the authors was completed and also compared to current literature regarding spirituality in cancer and other serious illness. Results: Findings demonstrate the broad scope of spirituality, key spiritual concerns in cancer and methodological approaches to assessing spirituality. Conclusion: Spirituality is a major concern for patients, yet limited training has been provided for clinicians who deliver this care. Additional studies are needed to advance this important aspect of palliative care. [ABSTRACT FROM AUTHOR]

Objective: Cancer places a psychological burden on both patients and their relatives. Perceived social support influences the extent of psychological distress. Our aim was to investigate associations between positive support, detrimental interactions, depression and anxiety in patient‐relative dyads in the initial period after diagnosis. Methods: Patients with a solid tumor and their relatives participated in this prospective, multicenter observational study. Participants answered validated measures including the Illness‐specific Social Support Scale (SSUK‐8), the Patient Health Questionnaire (PHQ‐9) and the General Anxiety Disorder Scale (GAD‐7). We analyzed cross‐sectional data from the initial time following diagnosis with paired t‐tests and actor‐partner interdependence models. Results: A total of 347 dyads of patients (mean age 59.9 years) and their relatives (mean age 56.7 years) participated. Compared to their relatives, patients reported significantly higher levels of depression (patients: M = 6.31, SD = 4.94; relatives: M = 5.44, SD = 4.77) and lower levels of anxiety (patients: M = 4.40, SD = 4.10; relatives: M = 4.98, SD = 4.47) as well as more positive support (patients: M = 14.31, SD = 2.07; relatives: M = 12.46, SD = 3.29) and a lower frequency of detrimental interactions (patients: M = 3.21, SD = 2.97; relatives: M = 3.66, SD = 2.93). Intrapersonal effects: Positive support was associated with lower distress only for relatives, whereas detrimental interactions were associated with higher distress for both patients and relatives (all p < 0.05). Interpersonal effects: More positive support and fewer detrimental interactions experienced by relatives were associated with lower patient distress (all p < 0.05). Conclusions: Better support for relatives may not only reduce their own distress, but also patients' distress. Relatives experience similar levels of distress and poorer social support than patients. [ABSTRACT FROM AUTHOR]

Purpose: This study examined the feasibility and acceptability of a three‐session, psychological‐based intervention to improve intimacy and sexuality outcomes among women with breast and gynaecologic cancer in Singapore. Method: Patients from outpatient oncology clinics completed screeners for marital and sexual distress. Those who endorsed either marital or sexual distress were invited into the study, and were randomized to receive the intervention immediately or be waitlisted. Intervention feasibility (i.e., reach, adherence) and acceptability (i.e., satisfaction, cultural sensitivity, willingness to pay) and marital, sexual, and body image outcome changes were examined. Results: 1101 patients completed the screener; 24% of patients with breast or gynaecologic cancer reported marital or sexual distress. Forty‐six patients who were eligible participated in the study. The majority (88%) of participants who started the intervention completed all 3 sessions. All (100%) participants who completed the intervention reported satisfaction and the majority (97%) reported they would recommend the intervention to a friend. The majority of participants found the intervention to be culturally sensitive (93%) and reported being willing to pay either out of pocket or through their national medical MediSave account (76%). Outcome changes were in expected directions with small effect sizes (0.24–0.42). Several themes emerged from open‐ended feedback on what participants found useful and how the intervention can be improved. Conclusions: Approximately one quarter of breast or gynaecologic cancer patient who are partnered in Singapore reported marital or sexual distress. Despite the low reach, we found good adherence and high acceptability of the psychological‐based intervention. Our findings suggest there is room to improve awareness and delivery of sexuality‐related care in an oncology setting. Trial Registration: Number and date: NCT03420547, April 10, 2018 [ABSTRACT FROM AUTHOR]

In this study, we applied the actor–partner interdependence model (APIM) to explore the associations between personality traits (Big Five) and psychological flexibility, on the one hand, and depression and anxiety, on the other hand, among patients with cancer and their spouses. Method: Forty-six patient—spouse dyads (N = 92) completed the anxiety and depression scales from the Patient-Reported Outcomes Measurement Information System (PROMIS), the ten-item personality inventory (TIPI), and the psychological flexibility scale (AAQ-2). Multilevel APIM models, adjusted for multiple testing, showed that neuroticism and psychological flexibility had actor effects on patients' depression and anxiety. Furthermore, neuroticism had actor effects on spouses' depression and anxiety, and agreeableness had actor effects on spouses' anxiety. In addition, patients' psychological flexibility and neuroticism had partner effects on spouses' depression. Conclusion: Being psychologically flexible but emotionally stable is important for one's own and one's partner's psychological outcomes in the context of dyadic coping with cancer. Implications include informing couples' therapists in the context of psycho-oncology on the importance of considering personality traits and improving psychological flexibility. [ABSTRACT FROM AUTHOR]

Objectives: There is evidence of a significant role for therapeutic alliance (TA) in psycho‐oncology care. This review aims to provide an overview by systematically identifying key characteristics of TA in this setting and exploring related concepts. Methods: PubMed, PsycInfo and Web of Science were systematically searched for empirical studies on adult cancer patients receiving psycho‐oncological care considering TA. Quality assessment was undertaken using the Mixed Methods Appraisal Tool. A narrative synthesis was conducted. Results: Of the 4647 identified publications, 24 quantitative, qualitative and mixed‐methods studies were included. Characteristics of studies, interventions and samples were heterogenic. Patients consistently reported high TA scores. Favourable associations of TA with distress and well‐being and mixed results for further outcomes and compliance were detected. Associations between the patient's and therapist's characteristics yielded mixed results. Qualitative evidence pointed to a unique nature of TA in psycho‐oncology, for example, patients experiencing it in the context of other patient–provider relationships occurring in the context of the disease. Conclusion: The review displays a unique synopsis of a heterogenic, quickly developing research field. First hints towards the efficacy and particularity of TA in psycho‐oncology are delivered. Results encourage further focus on TA, both in psycho‐oncological research and in clinical practice. [ABSTRACT FROM AUTHOR]

Death anxiety is associated with fears of suffering and uncertainty at the end of life. It is also relevant to patients' family caregivers, who can experience fears about the patients' death and dying. This study investigates the prevalence of death anxiety in advanced cancer patients and their family caregivers and its association with sociodemographic and medical characteristics. We recruited patients with UICC stage IV solid tumors from in- and outpatient oncology and palliative care settings. We administered the Death and Dying Distress Scale to assess clinically significant death anxiety. We analyzed its association with sociodemographic and medical characteristics using simultaneous multiple linear regression analyses. Death anxiety was prevalent in 37% of patients (N = 481) and 75% of family caregivers (N = 140). Most frequent death anxiety concerns were "feeling distressed about the impact of one's own death on loved ones" (52% of patients) and "feeling distressed about running out of time with their loved one" (69% of family caregivers). Patients who experienced high death anxiety were more likely to be younger (standardized β = -0.1; P= 0. 005) and have known about their diagnosis for less time (standardized β = -0.1; P= 0. 046). Being female predicted higher death anxiety in patients (β = 0.12; P= 0. 041) and family caregivers (β = 0.32; P= 0. 002). The results indicate that death anxiety is a common, clinically significant problem in patients with advanced cancer and their family caregivers, emphasizing the need for targeted psychological support. [ABSTRACT FROM AUTHOR]

Background: Access to cancer screening services is crucial for early detection and improved survival rates, yet older adults in Saudi Arabia face significant barriers. Recent data from the Saudi Health Ministry indicate that cancer incidence in this demographic is rising, underscoring the urgent need for enhanced screening efforts. This study explores the factors influencing cancer screening behaviors among older adults in Riyadh, using a mixed-methods approach to identify and address these barriers effectively. Methods: The study integrated quantitative data from 100 participants aged 60 and above who attended King Saud University-affiliated healthcare centers, and qualitative insights from 20 semi-structured interviews. The Barriers to Cancer Screening Scale (BCSS) quantitatively assessed barriers, while the thematic analysis of interview data helped identify key themes. Results: Findings revealed significant barriers, categorized into three primary themes: accessibility challenges, psychological barriers, and social influences. These include logistical difficulties related to transportation and service availability, fears and anxieties regarding cancer diagnoses, and a lack of family support and cultural stigma, all of which impact participants' willingness to engage in screening. Conclusion: The study underscores the multifaceted barriers faced by older adults in accessing cancer screening in Saudi Arabia. Tailored interventions that address logistical, psychological, and social factors are essential to enhance screening uptake and ensure equitable access to preventive services. These findings contribute to the ongoing discussions on public health strategies and underscore the necessity for community and healthcare provider engagement to improve cancer screening rates in this population. [ABSTRACT FROM AUTHOR]

Copyright of Cyprus Turkish Journal of Psychiatry & Psychology (CTJPP) / Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi is the property of Cyprus Turkish Journal of Psychiatry & Psychology (CTJPP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Der Schmerz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

"Ariadne's thread" is a psycho-educational intervention designed by the Breast Unit and the Clinical Psychology Unit of an Italian Comprehensive Cancer Center and aims to promote empowerment in patients with metastatic breast cancer. It consists of 8 online meetings led by a psycho-oncologist in which informative sessions by patients' referring physicians alternate with moments of stress management techniques. This study aims to investigate (1) the feasibility of the "Ariadne's thread" pilot intervention and (2) the satisfaction and perceived benefits of the pilot intervention. We used a mixed method approach in which (1) it was detected: the number of acceptance to the single session of the intervention by both patients and professionals, the number of help requests by patients, and the number of change of date requests by professionals; (2) semi-structured interviews were conducted with the professionals who participated in the intervention; (3) 2 focus groups were conducted with patients, and (4) a questionnaire was submitted to each of them. The intervention is sustainable from the perspective of the organization, professionals, and patients. In particular, the patients declared perceiving benefits in many aspects: improved relationships with doctors, acceptance of their illness, learning of a relaxation technique, possibility to look at the world with trust and hope, etc. The questionnaires show an improvement in empowerment and satisfaction as a result of the intervention. "Ariadne's thread" is a psycho-educational intervention that effectively addresses the needs of patients with MBC. It can be applied to other contexts (1) if it has been confirmed that similar needs exist or (2) if it can be modified to accommodate other needs. [ABSTRACT FROM AUTHOR]

Introduction: The main objective of this study was to fill the gap between the knowledge nurses have about psychosocial care and what they do about cancer patients' needs. It also aimed to devise ways to improve nursing education for nurses who could provide enhanced psychosocial support in such areas. Methods: This qualitative study relied on 18 in-depth interviews with nurses, with a focus on the difference between their understanding of psychosocial care and its application in helping cancer patients. This involved analyzing the transcribed interviews using thematic analysis. Data were collected from February to March 2024. Results: The verbal accounts of 18 participants were analyzed. These include theme 1 "holistic approach to cancer care" with the subtheme "navigating resource constraints:" theme 2 "nurses well-being and emotional input" with the subtheme "positive impact of psychosocial care:" theme 3 "Care for patients' well-being" with subtheme "resourcefulness and resilience in psychosocial care:" theme 4 "adapting care and building connections:" theme 5 "ideal and reality in psychosocial care" with subtheme "challenges in delivering comprehensive cancer care:" and theme 6 "empowering nurses for effective psychosocial care" with subtheme "building a strong foundation for psychosocial care." Conclusion: From the nurses' perspective, this study indicates a need for more inclusive cancer treatment. Therefore, in addition to physical interventions, emotions and social welfare must also be addressed. Although emotionally invested, health workers may offer assistance along psychosocial lines, thus aiding both patients and caretakers. Although individualized care with personal connections is crucial for effective services, this approach can make it difficult to ensure that all clients receive adequate psychological assistance. Hence, there has been a call to enhance the training to produce nurses who offer high-quality services. This study emphasizes a more holistic approach toward the emotional needs of patients while supporting those responsible for them in their sickness journey. [ABSTRACT FROM AUTHOR]

Abstract Background Nasopharyngeal carcinoma (NPC) patients often face significant physical and psychological challenges. While disease control remains a clinical priority, the impact on distress and health-related quality of life (HRQOL) is often overlooked. This study will assess distress and the HRQOL prevalence, severity, and relationship among post-treatment nasopharyngeal carcinoma (NPC) patients and investigate its associated factors. Method A cross-sectional study at Hospital Melaka (HM) and Hospital Canselor Tuanku Muhriz (HCTM) involved post-treatment NPC patients with at least six months of follow-up. Distress was assessed using the Distress Thermometer (DT). Quality of life (QoL) and symptomatology were assessed with the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) and EORTC Head and Neck Module (QLQ-H&N 35). We conducted statistical analyses using Kruskal–Wallis and Mann–Whitney U tests for comparisons and Spearman Correlation for analyzing relationships. Results One hundred forty-four patients with a median age of 60.5 years (range 18–92) were recruited and completed the questionnaires. The median NPC surveillance follow-up time was seven years (6 months to 36 years). 84% of the patients received concurrent chemoradiotherapy. The majority of the patients were in late stage 57.6% (Stage III, n = 51[35.4%]; Stage IV, n = 32 [22.2%]). The median distress score is 4 (range, 1–8), and the median HRQOL score is 75 (range of 50–100). A significant negative correlation was found between distress and the HRQOL score. (r = -0.53, p

Abstract Background Psychological distress often co-occurs with sleep disturbances; but the specific mechanisms linking the two remain unclear. A qualitative study explored perceptions and factors associated with sleep disturbances in cancer survivors between patients with varying levels of psychological distress. Methods Thirty-three Cantonese speaking mixed type cancer survivors were recruited from a community cancer care program. Participants that scored > 5 on the Pittsburgh Sleep Quality Index and had non-clinical or borderline to clinical levels of psychological distress underwent semi-structured interviews. Interviews were analyzed using grounded theory. Results Common triggers of sleep disturbances included unresolved treatment side-effects, intrusive thoughts about cancer and fear of cancer recurrence or progression, poor sleep hygiene and a lack of routine. Those with higher levels of distress exhibited more worry about recovery after cancer. Further, they engaged in thought suppression and experienced meta-worry about negative emotions and worry of poor sleep impacting recovery and cancer progression. They commonly exhibited high sleep reactivity and were observed to have limited social support. In contrast, those with low distress adopted better adaptive mechanisms, including a changed commitment to prioritizing health and positive reappraisal of their recovery progress. Self-distraction was used to cope with sleep disturbances and they had fewer expectations of good sleep quality. Conclusions Findings provided insights into the suitability of interventions for patients with sleep disturbances. Interventions targeting maladaptive emotion-focused coping may be more effective in addressing sleep disturbances in cancer survivors with higher distress. Interventions adopting a stepped-care approach may be advantageous in managing sleep disturbances by catering for varying levels of distress.

Introduction: In February 2022, we introduced the innovative new role of mental health nurse clinician (MHNC) in pediatric hematology/oncology in a pediatric hospital in Quebec with the aim of better addressing the needs of young cancer patients and their families. In two previous articles, we explained the method used to develop the role, as well as the strategy employed to implement it. Objectives: In this article, we seek to evaluate the effectiveness of the implementation strategy by measuring role feasibility. We will also examine role acceptability and appreciation 1 year following implementation. Methodology: We asked three groups of participants (adolescents, parents and care providers) to complete a research questionnaire based on the Theoretical Framework of Acceptability (TFA), with good inter-rater reliability and discriminant validity. The questionnaire, which was made available online, consisted of statements with Likert-scale responses (from 1 to 5), as well as open questions. We performed a standard descriptive analysis and used the responses to the open questions to support or add nuance to the quantitative results. Results: In total, 31 healthcare professionals, 10 adolescent cancer patients and 10 parents of adolescent cancer patients filled out the questionnaire. Between February 2022 and February 2023, the MHNC provided a total of 691 interventions to 112 individuals (patients and parents). Follow-up sessions were offered to 61 individuals, and 99.6% of them accepted. We found a very strong correlation (r = 0.96) between the number of hours worked by the MHNC and the number of interventions provided. The vast majority of participants from all three groups agreed that the role is appropriate, appreciated and necessary, and that it brings much-needed clinical expertise in mental health to the department. Care providers, adolescents, and parents indicated that they would request this service again and would recommend it to others, if it were needed. The results, therefore, demonstrate excellent feasibility and high levels of acceptability and appreciation. Conclusion: Our study shows that the implemented MHNC role helps improve the clinical management of the mental health of adolescents with cancer, as well as their parents. The role brings much-needed expertise in psychiatric nursing care and supports the clinical practice of care providers. Another study will be conducted in the near future to measure the effectiveness of the MHNC’s interventions.

Abstract Background PMP is a rare clinical syndrome characterized by the accumulation of mucinous material in the peritoneal cavity. The combination of CRS and HIPEC is the standard treatment, known to improve survival outcomes. However, follow-up adherence is critical for early detection of recurrence and extending survival. This study is the first to specifically investigate postoperative follow-up adherence in PMP patients treated with CRS and HIPEC. Aims To explore the socio-demographic and clinical determinants of follow-up adherence and its impact on survival in PMP patients treated with CRS and HIPEC. Methods This single-center, six-year retrospective study included 111 PMP patients who underwent CRS and HIPEC. Patients were categorized into compliant (control) and non-compliant (study) groups. Follow-up was initiated by the physician, with patients returning for regular visits as recommended. Kaplan-Meier analysis was used to evaluate survival outcomes, while univariate analysis identified factors influencing follow-up adherence. Results Among 111 patients, 32 died by August 2024, with 1-, 3-, and 5-year survival rates of 88%, 66%, and 53%, respectively. High PCI scores (P

Abstract Depression frequently comorbidities with cancer, adversely affecting survivors’ quality of life. Liver dysfunction is also prevalent among cancer survivors. However, the association between these two conditions remains unclear. This study aimed to explore the relationship between depression and liver function biomarkers in US cancer survivors. A cross-sectional study was conducted utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2005–2020. Cancer survivors were screened and depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), and 18 liver function biomarkers were included. Survey-weighted generalized linear models with multiple covariables adjusted were employed to examine the associations between depression and liver function biomarkers. A total of 4118 cancer survivors were included, representing a weighted population of 21 501 237. After adjusted with age, gender, race, marital status, education level, family income-to-poverty ratio, and number of cancer types, 8 biomarkers demonstrated positive correlations with depression in cancer survivors, included alanine aminotransferase (ALT, OR = 1.007, 95% CI: 1.000 to 1.013), alkaline phosphatase (ALP, 1.006 [1.002, 1.010]), gamma glutamyl transferase (GGT, 1.004 [1.001, 1.007]), lactate dehydrogenase (LDH, 1.004 [1.000, 1.009]), total protein (TP, 1.040 [1.009, 1.072]), globulin (GLB, 1.060 [1.030, 1.091]), total cholesterol (TC) to high-density lipoprotein cholesterol (HDL-C) ratio (1.162 [1.050, 1.286]), and low-density lipoprotein cholesterol (LDL-C) to HDL-C ratio (1.243 [1.012, 1.526]); while 4 other biomarkers exhibited negative correlations, included HDL-C (0.988 [0.980, 0.997]), total bilirubin (TBi, 0.501 [0.284, 0.883]), aspartate aminotransferase (AST) to ALT ratio (0.588 [0.351, 0.986]), albumin (ALB) to GLB ratio (0.384 [0.229, 0.642]). Following sensitivity analysis, 5 biomarkers included LDH, HDL-C, TBi, AST/ALT and LDL-C/HDL-C lost their statistical significance for the association. This study identified certain associations between 7 liver function biomarkers and depression in US cancer survivors. Further research, particularly prospective longitudinal studies, is warranted to elucidate the causal relationships and explore the potential of improving liver function for the management of depression in cancer patients.

Background Sense of coherence (SoC), a key concept in the theory of salutogenesis, influences the pathway to promote or maintain health. Utilising psycho-oncological care (PC) can be allocated to the dimension of ‘tension management’ within this theo-ry. We aimed to evaluate tension management and SoC in the context of PC by analysing whether PC consultations and therapeutic alliance influenced patients’ SoC over time. Participants and procedure Patients who received PC were surveyed twice (after 3 and 12 months) about their care experiences, including therapeutic alliance and SoC. Survey data were matched to care documentation data, which contain consultation dates and sociodemo-graphics. Four stepwise regression analyses were conducted with overall SoC and its subscales of meaningfulness, compre-hensibility and manageability at T2 as outcome variables. The predictors are therapeutic alliance and the number of consul-tations (T1). Results One hundred patients filled out all three SoC subscales at T1 and T2 and were treated by a psycho-oncologist. Therapeutic bond predicted the change in overall SoC (β = .34, t = 2.26, p = .026) and manageability (β = .47, t =3.02, p = .003). The num-ber of consultations predicted overall SoC (β = .16, t = 2.05, p = .043), meaningfulness (β = .21, t = 2.51, p = .014) and man-ageability (β = .17, t = 2.07, p = .041). Conclusions Our results suggest that part of successful tension management in PC is a good therapeutic bond and the number of needs-oriented consultations utilised. These predictors affect SoC subdimensions differently.

(1) Background: Clinical aspects like sex, age, Karnofsky Performance Scale (KPS) and psychosocial distress can affect the health-related quality of life (HR-QoL) and treatment satisfaction of patients with malignant isocitrate dehydrogenase wild-type (IDHwt) gliomas and caregivers. (2) Methods: We prospectively investigated the HR-QoL and patient/caregiver treatment satisfaction in a cross-sectional study with univariable and multiple regression analyses. Questionnaires were applied to investigate the HR-QoL (EORTC QLQ-C30, QLQ-BN20) and treatment satisfaction (EORTC PATSAT-C33). (3) Results: A cohort of 61 patients was investigated. A higher KPS was significantly associated with a better HR-QoL regarding the functional scales of the EORTC QLQ-C30 (p < 0.004) and a lower symptom burden regarding the EORTC QLQ-BN20 (p < 0.001). The patient treatment satisfaction was significantly poorer in the patients older than 60 years in the domain of family involvement (p = 0.010). None of the investigated aspects showed a significant impact on the treatment satisfaction of caregivers. (4) Conclusions: We demonstrated that in patients with IDHwt gliomas, the KPS was the most important predictor for a better HR-QoL in functional domains. Data on the HR-QoL and treatment satisfaction in patients with IDHwt gliomas and their caregivers are rare; therefore, further efforts should be made to improve supportive care in this highly distressed cohort.

Abstract Background Systematic reviews and meta-analyses reveal the importance of an accepting attitude towards cancer for mental health and functional coping. The aim of this study was to examine the psychometric properties of the German translation of the Peace, Equanimity, and Acceptance in the Cancer Experience (PEACE) questionnaire (Mack et al., 2008) and to investigate its associations with mental health, health-related quality of life (HRQoL) and related constructs. Methods The German version of the PEACE (PEACE-G) was created and validated with cancer patients in a cross-sectional two center questionnaire study. Construct validity was tested with confirmational factor analyses (CFA); Cronbach’s alpha was used to determine internal consistency of items. We further examined associations with depression (PHQ-8), anxiety (GAD-7), distress (NCCN distress thermometer), HRQoL (SF-12), psychological flexibility (AAQ-II), resilience (RS-11) and acceptance scales, to evaluate concurrent and divergent validity. Results N = 213 cancer patients with different tumor entities participated in this study. Results of the CFA replicated the two-factor solution of the original PEACE (peaceful acceptance and struggle with illness) with satisfactory psychometric properties. Peaceful acceptance showed negative associations with depression, anxiety, distress, psychological inflexibility, and positive associations with HRQoL, acceptance, resilience, and mindfulness. Results of sensitivity analyses indicate a third factor (injustice/anger). Conclusions The results demonstrate the validity and reliability of PEACE-G in cancer patients and point to the essential role of acceptance- and mindfulness-based interventions in psycho-oncology. Further studies are needed to investigate the different facets of struggle with the cancer illness.

Background: PMP is a rare clinical syndrome characterized by the accumulation of mucinous material in the peritoneal cavity. The combination of CRS and HIPEC is the standard treatment, known to improve survival outcomes. However, follow-up adherence is critical for early detection of recurrence and extending survival. This study is the first to specifically investigate postoperative follow-up adherence in PMP patients treated with CRS and HIPEC. Aims: To explore the socio-demographic and clinical determinants of follow-up adherence and its impact on survival in PMP patients treated with CRS and HIPEC. Methods: This single-center, six-year retrospective study included 111 PMP patients who underwent CRS and HIPEC. Patients were categorized into compliant (control) and non-compliant (study) groups. Follow-up was initiated by the physician, with patients returning for regular visits as recommended. Kaplan-Meier analysis was used to evaluate survival outcomes, while univariate analysis identified factors influencing follow-up adherence. Results: Among 111 patients, 32 died by August 2024, with 1-, 3-, and 5-year survival rates of 88%, 66%, and 53%, respectively. High PCI scores (P < 0.001) and poorer histopathological types (P = 0.002) were significant predictors of reduced survival. Non-compliance with follow-up showed a trend toward decreased survival (P = 0.07). Significant risk factors for non-compliance included lower ASA scores (P = 0.020), middle- and low-income levels (P = 0.034), and parental survival status (P = 0.003). Middle- and low-income patients also experienced longer delays in seeking medical advice and had fewer cases detected through routine health screenings (P = 0.019). Conclusions: Follow-up compliance has a potential impact on survival outcomes in PMP patients treated with CRS and HIPEC. Socio-demographic factors significantly influence adherence, highlighting the need for tailored interventions to enhance patient management. [ABSTRACT FROM AUTHOR]

Background: Early palliative care (EPC) is a recommended model for improving the quality of life for patients with advanced cancer and their caregivers. However, limited research has focused on the role of psychological evaluation within EPC. The Veneto Institute of Oncology (IOV), a Comprehensive Cancer Centre, employs an interdisciplinary team to assess patients with advanced-stage disease. This study aims to assess the psychological needs of these patients, investigate any correlations between psychological symptoms (PSs) and factors such as awareness of diagnosis and prognosis, symptoms detected using the Edmonton Symptom Assessment System (ESAS), as well as the patient's gender, age, social issues, and survival and to clarify the psychologist's role within the interdisciplinary team. Methods: Data were retrieved from a prospectively maintained database. From 1st January 2018 to 31st December 2021, 819 consecutive patients were evaluated during EPC consultations, with 753 participants enrolled in the study. The ESAS was administered to each patient before the consultation. Results: More than half of the patients (385, 57.1%) reported at least one PS, with an ESAS score of ≥4. Specifically, 34.9% reported depression, 28.7% reported anxiety, and 43.2% indicated feeling "not well." Referring oncologists tended to overestimate the presence of PSs compared to patient self-reports (51.8% versus 41.3%). According to the psychologists' assessment, 29.2% of participants were found to have depression, and 10.8% of participants had anxiety. Additionally, 31 patients (10.8%) with psychological disorders were diagnosed with an adaptation disorder related to a physical condition. The psychology service engaged 47% of patients, while 18.5% declined psychological support. Patients exhibiting other ESAS symptoms with scores of ≥4 had an increased odds ratio for reporting PSs of ≥4. However, multivariable analysis revealed no significant relationship between PSs and awareness of diagnosis and prognosis. Conclusion: The systematic use of self-assessment in EPC is essential for understanding patient's experience, determining whether PSs stem from physical disorders, and prioritizing interventions. Awareness of prognosis does not correlate with increased anxiety and depression in patients. Therefore, EPC is an ideal opportunity to discuss prognosis and facilitate patients' end-of-life choices early in their care journey. [ABSTRACT FROM AUTHOR]

Cancer is one of the leading causes of mortality, with new cases expected to rise. Medical advances increase cure rates and prolong patient lives, but survivorship involves high symptom burden, loss of function and emotional distress. Improving patient-centred care (PCC) and quality of life throughout the care process is essential. Key to this improvement are systematic use of patient-reported outcome measures (PROMs) and patient-centred care pathways (PCCPs). Despite established benefits, current cancer care focuses on tumour-centred care approaches often neglecting the patient perspective. Evidence-based PCC guidelines fail to be routinely incorporated into clinical practices. The Horizon 2020-funded European MyPath project aims to address these gaps by developing, implementing and evaluating digital PCCPs with PROMs. MyPath will be tailored to enhance the organisational contexts of cancer centres across Europe through the application of implementation science strategies. This paper describes the current state of applying PCC in routine cancer care and presents a forward-looking perspective on how the MyPath project can successfully adopt and implement digital PROMs across countries. A literature search was conducted to provide the state-of-the art. [ABSTRACT FROM AUTHOR]