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In recent years, exposures to organophosphate pesticide have been highlighted as a possible cause or aggravating factor of autism spectrum disorder (ASD). The present study examined if Wistar rats prenatally exposed to chlorpyrifos (CPF) at a dose of 1 mg/kg in GD 12.5-15.5 could express similar behaviors to those exposed to valproic acid (VPA, 400 mg/kg) during the same administration window, which is an accepted animal model of autism. The 3-chambered test was employed to evaluate sociability and reaction to social novelty in two experiments, the first in adolescence and the second in adulthood. The results obtained in this study show that animals prenatally treated with CPF or VPA show a similar behavioral phenotype compared to the control group (CNT). In adolescence, the CPF animals showed a negative index in the reaction to social novelty, followed closely by the VPA, while both experimental groups showed a recovery in this aspect during adulthood. This study therefore provides evidence to suggest that prenatal exposure to CPF in rats could have similar effects on certain components of sociability to those seen in autistic models.© 2024. The Author(s).

A central topic in psycholinguistics is the study of how and when the parser assigns an antecedent to referentially-dependent elements. One such referentially-dependent element is the null subject of non-finite clauses. The aim of the present study was to examine the role of verb control information in the assignment of an antecedent to such a null subject. The results so far are inconclusive. Some authors argue that verb control information has a late influence, whereas others argue that such verb-specific information has a very rapid influence. We report a self-paced reading study in Spanish in which verb type (subject vs. object control) and grammaticality (grammatical vs. ungrammatical) were manipulated. The grammaticality manipulation was carried out by introducing a person anomaly at the infinitive itself, and not at a later word (e.g., "Te prometi/aconseje adelgazarme/adelgazarte cinco quilos en un mes." Literal translation, "I to you promised/advised to losemyself/yourself five kilos in a month"). With such a manipulation we can examine whether at the first possible point (i.e., the infinitive) verb control information was used to assign the correct antecedent (i.e., the subject in sentences with a subject-control verb, and the object in sentences with an object-control verb) to PRO. The results showed that at the infinitive there was a main effect of grammaticality, meaning that the correct antecedent has already been assigned to PRO. The present findings are consistent with models that assume that verb-specific information plays an important role in the initial stages of sentence processing.

Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the mechanisms that may underlie its anti-addictive effects are still not defined. This study aims to identify changes in gene expression induced by a single oral dose of IBO in the cortex of mice by means of a transcriptomic analysis for the first time. Our results showed significant alterations in gene expression in mouse frontal cortex samples 4 h after a single oral dose of IBO. Specifically, genes involved in hormonal pathways and synaptogenesis exhibited upregulation, while genes associated with apoptotic processes and endosomal transports showed downregulation. The findings were further corroborated through quantitative polymerase chain reaction (qPCR) analysis. However, the validation of gene expression related to hormonal pathways did not entirely align with the transcriptomic analysis results, possibly due to the brain region from which tissue was collected. Sex differences were observed, with female mice displaying more pronounced alterations in gene expression after IBO treatment. High variability was observed across individual animals. However, this study represents a significant advancement in comprehending IBO's molecular actions. The findings highlight the influence of IBO on gene expression, particularly on hormonal pathways, synaptogenesis, apoptotic processes, and endosomal transports. The identification of sex differences underscores the importance of considering sex as a potential factor influencing IBO's effects. Further research to assess different time points after IBO exposure is warranted.© 2024. The Author(s).

Raw data for participants that answered the Statistical Anxiety Test. A sample of 681 undergraduate Spanish students (80% women) of a Grade in Psychology, aged 18-60 years (M = 20.5, SD = 4.9), completed the computer version of the test. Raw responses and the time to response each item were recorded. The test included a scale to assess social desirability In addition, the examination mark in a test about statistic was recorded for a set or participants (N=430). Total scores were computed as an addition to item responses. ORION factor score estimates in the scales of the test were obtained using factor analysis (ULS extraction, Robust Promin, and ORION scores estimates). The software used to compute the factor analysis was FACTOR. The information provided is: sample descriptives, participants' responses, item response times, and participants' scores in test scales. (2024-01-25)

Past research that distinguishes between affective and neutral words has predominantly relied on two-dimensional models of emotion focused on valence and arousal. However, these two dimensions cannot differentiate between emotion-label words (e.g., fear) and emotion-laden words (e.g., death). In the current study, we aimed to determine the unique affective characteristics that differentiate emotion-label, emotion-laden, and neutral words. Therefore, apart from valence and arousal, we considered different affective features of multi-componential models of emotion: action, assessment, expression, feeling, and interoception. The study materials included 800 Spanish words (104 emotion-label words, 340 emotion-laden words, and 356 neutral words). To examine the differences between each word type, we carried out a Principal Component Analysis and a Random Forest Classifier technique. Our results indicate that these words are characterized more precisely when the two-dimensional approach is combined with multi-componential models. Specifically, our analyses revealed that feeling, interoception and valence are key features in accurately differentiating between emotion-label, emotion-laden, and neutral words.

Prenatal iron supplementation improves children's health and cognitive performance, but few studies explore behavioural development. This study assessed the effects of adjusting prenatal iron supplementation to maternal iron stores during early pregnancy on children's behavioural problems. Randomized controlled trial conducted in Tarragona (Spain) involving 230 nonanaemic pregnant women and their children after a 4-year follow-up. Based on haemoglobin (Hb) levels before gestational week (GW) 12, women receive different iron doses: those with Hb = 110-130 g/L were randomized to receive 80 or 40 mg/day and those with Hb > 130 g/L were randomized to receive 20 or 40 mg/day. Maternal iron stores at GW12 were classified using serum ferritin (SF) as low (SF < 15 µg/L), normal (SF = 15-65 µg/L), and normal-high (SF > 65 µg/L). Children's behaviour was assessed by parents using the Child Behaviour Checklist for ages 1.5-5 years and the Behaviour Rating Inventory of Executive Function-Preschool Version, and by teachers using the Teacher's Report Form for ages 1.5-5 years. Multivariable regression models were performed. Taking 80 mg/day of iron improved child behaviour when women had low iron stores but worsened it when mothers had normal-high iron stores, except for depressive and attention/hyperactivity problems. Taking 20 mg/day of iron improved behaviour only in those children whose mothers had SF > 65 µg/L in early pregnancy. Additionally, executive functioning improved at high doses of prenatal iron when maternal baseline SF < 15 µg/L. Adjusting prenatal iron supplementation to both maternal baseline Hb levels and iron stores reduces behavioural problems in 4-year-old children.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.

Emotional Intelligence (EI) has received a lot of interest after all evidence on its favor is accumulating and research shows that EI can be taught. Through a theoretical review and reflective process, the aim of this paper is to propose a body focused intervention model with examples to teach EI competencies using Dance Movement Therapy (DMT). In particular, Laban Movement Analysis and body awareness elements in which the DMT EI model is supported. The model is organized in four modules, each module is associated with a EI branch, a social-emotional skill, a DMT element, an exploration quality and an aimed outcome.

The objective of this literature review is to look for the possible benefits of using DMT for hypermobile Ehlers Danlos (hEDS) and Hypermobile Spectrum Disorders (HSD). This research can help create a new theoretical framework in which DMT can be connected to this population as it is with similar populations. There is a gap in the literature review that this work tries to fill. However, further research with this population using DMT will be necessary., L'objectiu d'aquesta revisió de la literatura és buscar els possibles beneficis de l'ús de DMT per a Ehlers Danlos hipermòbils (hEDS) i trastorns de l'espectre hipermòbil (HSD). Aquesta investigació pot ajudar a crear un nou marc teòric en què la DMT es pugui connectar a aquesta població com passa amb poblacions similars. Hi ha un buit en la revisió de la literatura que aquest treball intenta omplir. Tanmateix, caldrà més investigació amb aquesta població que utilitzi DMT. Hi ha un buit en la revisió de la literatura que aquest treball intenta omplir. Tanmateix, caldrà més investigació amb aquesta població que utilitzi DMT.

En el presente artículo se analiza el trastorno del vínculo, en base a las teorías del apego para alcanzar su comprensión y detectar las consecuencias psíquicocorporales de sus trastornos derivados desde un enfoque metodológico teóricopráctico realizando una revisión bibliográfica en el ámbito de interés, como soporte y justificación de una propuesta de intervención. A través de dicho análisis se observa que un desarrollo de apego en situaciones y experiencias diversas como maltrato físico y/o psicológico, abuso, abandono, cuidados negligentes de los cuidadores principales, su incapacidad de vincular de un modo sano o a causa de separaciones traumáticas por pérdida, enfermedad o encarcelamiento del cuidador en cuestión, generan cuadros sintomatológicos que requieren de intervención clínica. En el presente artículo se propone, desde esta revisión, la Danza Movimiento Terapia como modelo de intervención enlazando sus diversas técnicas y herramientas para el abordaje de los síntomas detectados, con el objetivo de ofrecer una guía básica para profesionales de la DMT que se inician en el ámbito clínico., Aquest article analitza el trastorn de l'enllaç, en base a les teories de l'aferrament per assolir la seva comprensió i detectar les conseqüències psíquico-corporals dels seus trastorns derivats des d'un enfocament metodològic teòric-pràctic realitzant una revisió bibliogràfica, com a suport i justificació de una proposta dintervenció. L'anàlisi mostra que el desenvolupament d'aferraments poc segurs pot generar símptomes que requereixen intervenció clínica. Es proposa la Dansa Moviment Teràpia com a model d'intervenció enllaçant les diverses tècniques i eines, amb l'objectiu d'oferir una guia bàsica per a professionals de la DMT que s'inicien a l'àmbit clínic.

The following qualitative study uses a mixed-methods approach to highlight three main mechanisms and their corresponding intervention techniques through which Dance Movement Therapy (DMT) could help understand how mind, body, and emotion interact in individual pain experiences, ultimately aiming toward improved pain management and well-being. These three mechanisms-identifying pain triggers, developing coping mechanisms for chronic pain, and creating vehicles for expression-will be supported with a literature review on relevant themes related to chronic pain and DMT as well as through the analysis of case studies of three patients suffering from chronic pain that participated in DMT sessions conducted by the researcher., El següent estudi qualitiu utilitza un sistema de mètodes mixtos per destacar tres mecanismes i les seves corresponents tècniques d'intervenció mitjançant els quals la Dansa Moviment Teràpia (DMT) podria ajudar a entendre com la ment, el cos i l'emoció interactuen en les experiències individuals del dolor. Aquests tres mecanismes són: identificar els desencadenants del dolor, desenvolupar mecanismes per gestionar el dolor crònic i crear vies per a la seva expressió. L'estudi serà recolzat amb una revisió de la literatura així com amb l'anàlisi de casos pràctics de tres pacients que van participar en sessions de DMT realitzades per la investigadora.

In this prospective cohort study of 434 mother-infant pairs from the ECLIPSES study, we examine the association between maternal vitamin B12 status at the beginning and end of pregnancy and the neurodevelopmental outcomes of infants 40 days after birth in a pregnant population from a Mediterranean region of northern Spain. Maternal vitamin B12 concentrations were determined in the first and third trimesters, and sociodemographic, nutritional, and psychological data were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III (BSID-III, cognitive, language, and motor skills) were administered to the infants and several obstetrical data were recorded. In the multivariable models, medium maternal first-trimester vitamin B12 levels (312 to 408 pg/mL, tertile 2) were associated with better neonatal performance in the motor, gross motor, language, and cognitive skills with respect to tertile 1 (<312 pg/mL). The probability of obtaining a neonatal motor, gross motor, and receptive language score >75th percentile was significantly higher also in the tertile 2 group. In summary, good maternal vitamin B12 status in the early stage of pregnancy appears to be associated with better infant motor, language, and cognitive performance at 40 days postpartum.

Background: A current area of research interest is the association between ADHD and weight status. This paper aimed to describe the anthropometric status of school children with ADHD, considering age and clinical presentation (inattentive, hyperactive-impulsive, or combined), compared with control children. Methods: Participants came from the “Epidemiological Research Project on Neurodevelopmental Disorders” and consisted of 198 preschoolers (41 with ADHD) and 389 elementary school children (163 with ADHD). ADHD was diagnosed using DSM-5 criteria. Anthropometric measurements were taken at various anatomical points, and height, weight, and body composition were also measured. Results: In preschoolers, an association was found between hyperactive-impulsive ADHD and greater height and lower waist-to-height ratio. In elementary school children, regardless of the medication, combined ADHD was associated with smaller head, hip, arm, and thigh circumferences and lower weight, height, and BMI. A total of 19.7% of them were underweight. In contrast, children with inattentive and hyperactive/impulsive presentations presented the highest percentage of overweight/obesity (56%). Conclusion: The anthropometric status of the school children with ADHD showed differences in terms of age and presentation. Preschoolers with hyperactive-impulsive ADHD are taller, and elementary school children with combined ADHD are shorter and smaller than their age-matched control peers. Impact: The anthropometric status of the school children with ADHD showed differences in terms of age and presentation.Preschoolers with hyperactive-impulsive ADHD are taller than their control peers.Elementary school children with combined ADHD, regardless of the pharmacological treatment, are shorter and smaller than t

Chronic pain is a common problem in adults that can have a significant impact on individuals' quality of life and on society. The complex pain experience emerges from a dynamic combination of biological, psychological, and social factors. Previous research has shown that social support has positive effects on health-related outcomes through two mechanisms: direct-effects and stress-buffering effects. The aim of this study was to investigate the role that perceived stress, perceived social support, and their interaction play as predictors of global physical health and global mental health in adults with chronic pain.One hundred sixty-five adults with chronic pain completed measures of pain, perceived stress, perceived social support, global physical health, and global mental health.Perceived stress but not perceived social support made a significant and independent contribution to the prediction of global physical health; both perceived stress and perceived social support made independent contributions to the prediction of global mental health. The perceived stress × perceived social support interaction did not make a significant contribution to the prediction of either criterion variable. The results suggested that perceived stress has an impact on both global physical and mental health, whereas perceived social support associated mostly with global mental health. In addition, perceived social support does not appear to moderate the impact of stress on global physical and mental health.The findings are more consistent with a direct-effects model than a stress-buffering model of social support.© 2023. The Author(s).

The words we use to describe emotions vary in terms of prototypicality; that is, some of these words may be more representative of the semantic category of emotion than others (e.g., anger refers more clearly to an emotion than boredom). Based on a multicomponential conception of emotions, the aim of the present study was to examine the contribution of several variables to emotion prototypicality. Some of those variables are related to the distinct components of emotions: evaluation, action, body expression, internal body sensations (interoception), and feelings. Other variables are related to the concreteness/abstractness distinction: sensory experience, social interaction, thought, and morality. We collected ratings for these variables for a large set of words (1,286) which varied in emotion prototypicality. A regression analysis revealed that the variables that most contributed to emotion prototypicality were feelings and interoception. Furthermore, a factor analysis identified two underlying factors: socioemotional polarity and emotional experience. The scores of each word in both factors were used to create a two-dimensional space and a density plot which provides relevant information about the organization of emotion concepts in memory. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

In the present study we explore whether gender congruency between languages modulates bilinguals’ access to their second language words presented in isolation. We predicted that accessing L2 words that have a different gender across languages (gender-incongruent) would be more costly and require more effort than accessing same-gender words (gender-congruent) due to language co-activation, even when no access to L1 was required to perform the task. Additionally, we intended to shed some light into the mechanism underlying the gender congruency effect. To these aims, we compared the performance of Spanish native speakers with that of Italian-Spanish bilinguals (Italian native speakers) during a lexical decision task. The participants saw Spanish words that were gender-congruent and gender-incongruent between languages while event related potentials were recorded. Moreover, as an additional manipulation, we selected nouns that in both languages could be ambiguous or unambiguous. With the aim to examine whether the underlying mechanism is activation of multiple information during word processing, we focused on the N400 component, related with the effort to integrate lexical-semantic information: higher N400 amplitudes indicate greater effort. According to our prediction, Italian-Spanish bilinguals produced more errors and evoked larger N400 amplitudes when accessing gender-incongruent than gender-congruent words, while no differences appeared for Spanish native speakers between conditions. These results indicate that gender-incongruent words are harder to integrate compared with gender-congruent words, and that bilinguals automatically activate the grammatical gender of both languages during L2 language comprehension. Nevertheless, the results do not seem to support the ass

Ambiguous words can have related meanings (polysemes, e.g., newspaper) or unrelated meanings (homonyms, e.g., bat). Here we examined the processing of both types of ambiguous words (as well as unambiguous words) in tasks of increasing level of semantic engagement. Four experiments were conducted in which the degree of semantic engagement of the task was manipulated: lexical decision task (Experiments 1 and 2), semantic categorization task (Experiment 3) and number-of-meanings task (Experiment 4). RTs and pupillary response were recorded. To our knowledge, pupillary response had never been used before to study ambiguous words processing in isolation. Results showed faster RTs for ambiguous words with respect to unambiguous words in LDT, and larger pupil dilation was observed for ambiguous words in comparison to unambiguous ones in number-of-meanings task. However, differences between polysemes and homonyms were not observed in any task. These results provide no evidence that polysemes and homonyms are processed differently.Copyright © 2023. Published by Elsevier B.V.

Job transformation is changing work characteristics at a fast pace. This makes work design matter more than ever before. The Work Design Questionnaire (WDQ) is a powerful measurement of current work characteristics that can be used when (re)designing work to be safe, healthy, and motivating. However, its length represents a relevant challenge to its application. This study aims to validate a short version of the WDQ (WDQ-S) for Spanish-speaking countries. Through a two-waves longitudinal design, the WDQ-S was validated in a sample of 653 workers from 27 Spanish companies. Results confirmed the hierarchical factor structure, which comprised four general and nine specific dimensions, good internal consistency, and acceptable levels of convergent and discriminant validity. Hierarchical regression analyses showed predictive and incremental validity on job satisfaction and performance. The main limitation is that the WDQ-S was not tested against the original version, instead test-retest reliability was performed. Future research should replicate these findings in other samples, validate this scale in other languages and expand research with other outcomes. This study is relevant to in-dustrial and occupational ergonomics as it provides a useful tool for designing healthy, productive, and sus-tainable workplaces.

Up to 9.5% of the world’s population is diagnosed with attention deficit/hyperactivity disorder (ADHD), making it one of the most common childhood disorders. Air pollutants could be considered an environmental risk condition for ADHD, but few studies have specifically investigated the effect of prenatal exposure. The current paper reviews the studies conducted on the association between prenatal air pollutants (PM, NOx, SO2 , O3 , CO and PAH) and ADHD development in children. From the 890 studies searched through PubMed, Google Scholar, Scopus, and Web of Science, 15 cohort studies met the inclusion criteria. NOS and WHO guidelines were used for quality and risk of bias assessment. The accumulative sample was 589,400 of children aged 3–15 years. Most studies reported an association between ADHD symptoms and prenatal PAH and PM exposure. Data available on NO2 and SO2 were inconsistent, whereas the effect of CO/O3 is barely investigated. We observed heterogeneity through an odd ratio forest plot, and discrepancies in methodologies across the studies. Eight of the fifteen studies were judged to be of moderate risk of bias in the outcome measurement. In a nutshell, future studies should aim to minimize heterogeneity and reduce bias by ensuring a more representative sample, standardizing exposure and outcome assessments

It was carried out a simulation study that took into account the item properties of extremeness (difficulty, location) and consistency. The background idea is that a scale should be defined by a minimum of five items. In addition, averaged bias and sampling error of the five items were also inspected. Files included in the dataset: Data LINEAL: The items are analysed based on linear factor analysis; Data GRADED: The items are analysed based on no-linear factor analysis (2023-06-15)

This article assesses nutritional intake and adequacy in children with autism spectrum disorder (ASD), subdiagnostic autistic symptoms and children with typical development (TD). In total, 77 children diagnosed with ASD, 40 with subdiagnostic autistic symptoms and 333 children with TD were assessed. A validated food frequency questionnaire was used. Very few nutritional differences were found between ASD and TD groups. Preschool children with ASD and subdiagnostic autistic symptoms had slightly lower intake of monounsaturated fatty acids (MUFA), vitamin D and vitamin B12, and primary school children with ASD and subdiagnostic autistic symptoms had slightly higher intake of protein, cholesterol, thiamine and niacin, and a higher percentage of obesity than children with TD. All samples had an unbalanced energy intake (high in added sugars, fats and saturated fatty acids (SFAs); extremely inadequate intake (80%–100%) of vitamins D and E; high intake (50%–80%) of fibre, b-carotene (except preschool children with TD), calcium (except preschool children) and magnesium). The fact that differences between diagnoses are scarce may be related to the low level of ASD severity in this school sample. Lay abstract: Children with autism spectrum disorder (ASD) have a fivefold elevated risk of developing eating problems, which predisposes them to nutritional deficiencies. This study assesses nutritional intake and adequacy in children with ASD, subdiagnostic autistic symptoms and typically developing (TD) children. Preschool children with ASD and subdiagnostic symptoms had slightly lower intake of monounsaturated fatty acids (MUFA), vitamin D and vitamin B12. Primary school children with ASD and subdiagnostic symptoms had slightly higher intake of protein, cholesterol, thiamine and nia

Introduction: Those who are professionally dedicated to teaching can be exposed with their work to situations that influence their perception of psychological well-being. This study aims to evaluate how the factors of personality, emotional intelligence, burnout and the psychosocial climate derived from the work environment of teachers influence their levels of psychological well-being, to verify whether these variables allow us to establish a predictive model of psychological well-being by means of multiple regression analysis. Methods: Participants were a group of 386 teachers in early childhood, Primary and Secondary education, both in training and in active service (71.5% women; 28.5% men). A correlation and multiple regression analysis were performed to establish a predictive model of psychological well-being. We used 5 instruments: Psychosocial Climate at Work Scales (ECPT); verall Personality Assessment Scale (OPERAS); Questionnaire for Evaluation of Burnout Syndrome at Work (CESQT); Spanish adaptation of the Riff Psychological Well-being Scales (EBP) and Spanish validation of the Trait Meta-Mood Scale (TMMS-24). Results: Most of the relationships were significant, and the multiple regression analysis explains 58.5% of the global variance of psychological well-being in teachers, being emotional stability the most relevant and main predictor of psychological well-being, explaining its 38.1%. Discussion: Personality shows a great influence in psychological well-being of teachers, particularly emotional stability. The ability to establish predictive models to explain psychological well-being in educational environments is confirmed.

El acoso escolar es altamente prevalente entre niños/adolescentes con TDAH. Se estudió la victimización por acoso escolar autopercibida y las características sociodemográficas, psicopatológicas, cognitivas y académicas relacionadas en preadolescentes con TDAH en comparación con un grupo control. Método: Participaron 424 preadolescentes, 138 con TDAH. La victimización por acoso autopercibida se evaluó con el cuestionario de Acoso y Violencia Escolar. Este trabajo forma parte de un estudio epidemiológico transversal en doble fase más amplio. Resultados: El 35% de los preadolescentes con TDAH reportaron haber sido víctimas de acoso escolar. El TDAH-presentación combinada mostró la mayor coocurrencia de victimización por acoso autopercibida. Controlados los efectos del nivel socioeconómico, sexo, lugar de nacimiento, coeficiente intelectual y autismo, esta presentación aumentaba casi 3-veces la probabilidad de victimización por acoso autopercibida. El TDAH y la percepción de victimización se asociaron significativamente con altas tasas de coocurrencia de problemas psicológicos internalizantes/externalizantes. La comorbilidad con TEA fue mayor en el TDAH + acoso. Los preadolescentes TDAH tenían puntuaciones cognitivas más bajas y peores resultados académicos, independientemente de si estaban siendo acosados. Conclusiones: En prevención e intervención del bullying debe prestarse especial atención al TDAH como factor de vulnerabilidad, con consecuencias negativas para el bienestar emocional y comportamiento.

A frequent criticism of exploratory factor analysis (EFA) is that it does not allow correlated residuals to be modelled, while they can be routinely specified in the confirmatory (CFA) model. In this article, we propose an EFA approach in which both the common factor solution and the residual matrix are unrestricted (i.e., the correlated residuals need not be specified a priori). The estimation procedures are two-stage and based on the unweighted least squares principle. Procedures for judging the solution appropriateness (including goodness of fit) are also proposed. The simulation studies and illustrative example suggest that the approach works quite well Although the proposal is based on existing results, most of the developments can be considered to be new contributions, and are expected to be particularly useful in the earlier stages of item calibration. The whole procedure has been implemented in both R language and a well-known non-commercial EFA program.

Children and adolescents with chronic pain are a vulnerable population who often lack the resources to manage their condition. Due to high personal, social, and economic consequences, proper management in its early stages is key to reducing disability. The aim of this project is to co-develop a digital intervention for pediatric chronic pain (Digital SPA) with end-users and to evaluate its effectiveness and implementation outcomes in Spain.(Phase 1) Focus groups with patients, parents, and clinicians (n = 5-6 each) will inform about unmet pain care needs and provide a starting point for co-designing the intervention. (Phase 2) Content creation and usability testing will be based on the results of Phase 1, and the theory-driven development will follow the latest available evidence. The intervention will use validated psychological techniques focused on improving functioning by teaching pain coping skills. (Phase 3) Hybrid effectiveness-implementation trial. Participants (n = 195) will be adolescents aged 12-17 years old with chronic pain and one of their parents. Assessments include physical function, pain, sleep, anxiety, mood, satisfaction and adherence to the treatment, and number of visits to the emergency room. A qualitative framework analysis will be conducted with data from Phase 1. Effects of the intervention will be evaluated using linear multilevel modeling. The Consolidated Framework for Implementation Research (CFIR) and Behavioral Interventions Using Technology (BIT) frameworks will be used to evaluate implementation.This study is expected to produce a co-created evidence-based digital intervention for pediatric chronic pain and a roadmap for successful implementation.ClinicalTrials.gov (registered on 26 June 2023: https://clinicaltrials.gov/study/NCT0591762

The COVID-19 pandemic has had a devastating impact on the health and wellbeing of the global population. This paper presents the results of a longitudinal transcultural study that was begun at the peak of the pandemic (in April, 2020). An online survey was used to collect data from English-, Spanish-, and Portuguese-speaking participants. The survey collected information about sociodemographics, lifestyle activities, COVID-19-related circumstances, and drug use (with an emphasis on hallucinogenic drugs), as well as involving psychometric questionnaires. Users of hallucinogenic drugs had higher psychological well-being and lower scores on psychopathology scales, both at baseline and during follow-ups. This difference was larger when users were distinguished by frequency of use, as regular users scored higher on psychological well-being and lower on psychopathology scales. Subjects with more psychological distress had lower scores for all scales of post-traumatic growth, but if they were regular hallucinogens users, they had higher scores for post-traumatic growth. When comparing the results between cultural contexts, heterogeneous results were obtained. There were more English-speaking regular users of hallucinogenic drugs. Further research should analyse the potential role of hallucinogens in large-scale catastrophes, with a special focus on post-traumatic growth.

Despite ample evidence for transdiagnostic interventions in clinical populations and in universal prevention approaches, there are only a few controlled trials examining their role for indicated prevention. This study is the first randomized controlled trial to assess the effectiveness of a brief, 8-session group version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A), called PROCARE-I (Preventive Transdiagnostic Intervention for Adolescents at Risk for Emotional Disorders-Indicated), delivered online, and including a booster session, in reducing symptoms of anxiety and depression in adolescents compared to an active control condition. Sixty-four adolescents (53% identifying as female) with elevated levels of anxiety and/or depression were randomly assigned to either the 8-week PROCARE-I or the active control condition. Self-report, parent, and clinician measures were collected before and after the interventions, at the 6-month follow-up, and 1 month after the booster session. After the intervention, participants in the PROCARE-I group showed improved scores on 9 of the 13 primary and secondary outcome measures, including reduction of anxiety and mood symptomatology, level of risk of developing emotional disorders, resilience, as well as increase of psychological flexibility, and emotional regulation. In contrast, those in the control group showed improvements in only 2 of the 13 outcome measures. After the booster session, significant differences were found between the PROCARE-I and control condition on measures of overall anxiety and depression symptoms, emotional risk, resilience, and quality of life. Low dropout rates and limited incidence of emotional disorders were observed at follow-ups. The interventions were we

IntroductionDespite an emerging understanding regarding the pivotal mechanistic role of subjective experiences that unfold during acute psychedelic states, very little has been done in the direction of better characterizing such experiences and determining their long-term impact. The present paper utilizes two cross-sectional studies for spotlighting - for the first time in the literature - the characteristics and outcomes of self-reported past experiences related to one's subjective sense of death during ayahuasca ceremonies, termed here Ayahuasca-induced Personal Death (APD) experiences.MethodsStudy 1 (n = 54) reports the prevalence, demographics, intensity, and impact of APDs on attitudes toward death, explores whether APDs are related with psychopathology, and reveals their impact on environmental concerns. Study 2 is a larger study (n = 306) aiming at generalizing the basic study 1 results regarding APD experience, and in addition, examining whether APDs is associated with self-reported coping strategies and values in life.ResultsOur results indicate that APDs occur to more than half of those participating in ayahuasca ceremonies, typically manifest as strong and transformative experiences, and are associated with an increased sense of transcending death (study 1), as well as the certainty in the continuation of consciousness after death (study 2). No associations were found between having undergone APD experiences and participants' demographics, personality type, and psychopathology. However, APDs were associated with increased self-reported environmental concern (study 1). These experiences also impact life in profound ways. APDs were found to be associated with increases in one's self-reported ability to cope with distress-causing life problems and the sense of

In recent years, assumptions about the existence of a single construct of happiness that accounts for all positive emotions have been questioned. Instead, several discrete positive emotions with their own neurobiological and psychological mechanisms have been proposed. Of note, the effects of positive emotions on language processing are not yet properly understood. Here we provide a database for a large set of 9000 Spanish words scored by 3437 participants in the positive emotions of awe, contentment, amusement, excitement, serenity, relief, and pleasure. We also report significant correlations between discrete positive emotions and several affective (e.g., valence, arousal, happiness, negative discrete emotions) and lexico-semantic (e.g., frequency of use, familiarity, concreteness, age of acquisition) characteristics of words. Finally, we analyze differences between words conveying a single emotion ("pure" emotion words) and those denoting more than one emotion ("mixed" emotion words). This study will provide researchers a rich source of information to do research that contributes to expanding the current knowledge on the role of positive emotions in language. The norms are available at https://doi.org/10.6084/m9.figshare.21533571.v2.© 2023. The Author(s).

The cross-linguistic gender congruency effect (GCE; a facilitation on gender retrieval for translations of the same gender) is a robust phenomenon analysed almost exclusively with late bilinguals. However, it is important to ascertain whether it is modulated by age of acquisition (AoA) and language proficiency. We asked 64 early and late bilinguals of European Portuguese and German to do a forward and backward translation task. A measure of language balance was calculated through the DIALANG test. Analyses included this factor along with the gender congruency between translations, the target language, and the AoA of both languages, among others. Results showed a GCE for European Portuguese that was independent of the AoA and greater the higher the language imbalance. We propose that changes in proficiency in any of the languages create situations of dependency between them which allow cross-linguistic gender interaction to occur and effects to emerge depending on gender transparency.