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2. Characterization of gray matter volume changes from one week to 6 months after termination of electroconvulsive therapy in depressed patients

Author

Laroy, Maarten, Bouckaert, Filip, Ousdal, Olga Therese, Dols, Annemieke, Rhebergen, Didi, van Exel, Eric, van Wingen, Guido, van Waarde, Jeroen, Verdijk, Joey, Kessler, Ute, Bartsch, Hauke, Jorgensen, Martin Balslev, Paulson, Olaf B., Nordanskog, Pia, Prudic, Joan, Sienaert, Pascal, Vandenbulcke, Mathieu, Oltedal, Leif, and Emsell, Louise

Published
2024
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3. Longitudinal Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Pharmacotherapy in Major Depressive Disorder in Older Adults: Phase 2 of the PRIDE Study

Author

Lisanby, Sarah H., McClintock, Shawn M., McCall, William V., Knapp, Rebecca G., Cullum, C. Munro, Mueller, Martina, Deng, Zhi-De, Teklehaimanot, Abeba A., Rudorfer, Matthew V., Bernhardt, Elisabeth, Alexopoulos, George, Bailine, Samuel H., Briggs, Mimi C., Geduldig, Emma T., Greenberg, Robert M., Husain, Mustafa M., Kaliora, Styliani, Latoussakis, Vassilios, Liebman, Lauren S., Petrides, Georgios, Prudic, Joan, Rosenquist, Peter B., Sampson, Shirlene, Tobias, Kristen G., Weiner, Richard D., Young, Robert C., and Kellner, Charles H.

Published
2022
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4. Characterization of gray matter volume changes from one week to 6 months after termination of electroconvulsive therapy in depressed patients

Author

Acuut & Intensieve Zorg Med., Brain, Laroy, Maarten, Bouckaert, Filip, Ousdal, Olga Therese, Dols, Annemieke, Rhebergen, Didi, van Exel, Eric, van Wingen, Guido, van Waarde, Jeroen, Verdijk, Joey, Kessler, Ute, Bartsch, Hauke, Jorgensen, Martin Balslev, Paulson, Olaf B., Nordanskog, Pia, Prudic, Joan, Sienaert, Pascal, Vandenbulcke, Mathieu, Oltedal, Leif, Emsell, Louise, for GEMRIC, Acuut & Intensieve Zorg Med., Brain, Laroy, Maarten, Bouckaert, Filip, Ousdal, Olga Therese, Dols, Annemieke, Rhebergen, Didi, van Exel, Eric, van Wingen, Guido, van Waarde, Jeroen, Verdijk, Joey, Kessler, Ute, Bartsch, Hauke, Jorgensen, Martin Balslev, Paulson, Olaf B., Nordanskog, Pia, Prudic, Joan, Sienaert, Pascal, Vandenbulcke, Mathieu, Oltedal, Leif, Emsell, Louise, and for GEMRIC

Published
2024

5. Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Venlafaxine in Geriatric Depression: Phase 1 of the PRIDE Study

Author

Lisanby, Sarah H., McClintock, Shawn M., Alexopoulos, George, Bailine, Samuel H., Bernhardt, Elisabeth, Briggs, Mimi C., Cullum, C. Munro, Deng, Zhi-De, Dooley, Mary, Geduldig, Emma T., Greenberg, Robert M., Husain, Mustafa M., Kaliora, Styliani, Knapp, Rebecca G., Latoussakis, Vassilios, Liebman, Lauren S., McCall, William V., Mueller, Martina, Petrides, Georgios, Prudic, Joan, Rosenquist, Peter B., Rudorfer, Matthew V., Sampson, Shirlene, Teklehaimanot, Abeba A., Tobias, Kristen G., Weiner, Richard D., Young, Robert C., and Kellner, Charles H.

Published
2020
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7. Effects of continuation electroconvulsive therapy on quality of life in elderly depressed patients: A randomized clinical trial

Author

McCall, W. Vaughn, Lisanby, Sarah H., Rosenquist, Peter B., Dooley, Mary, Husain, Mustafa M., Knapp, Rebecca G., Petrides, Georgios, Rudorfer, Matthew V., Young, Robert C., McClintock, Shawn M., Mueller, Martina, Prudic, Joan, Greenberg, Robert M., Weiner, Richard D., Bailine, Samuel H., Youssef, Nagy A., McCloud, Laryssa, and Kellner, Charles H.

Published
2018
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9. Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients

Author

McCall, W. Vaughn, Lisanby, Sarah H., Rosenquist, Peter B., Dooley, Mary, Husain, Mustafa M., Knapp, Rebecca G., Petrides, Georgios, Rudorfer, Matthew V., Young, Robert C., McClintock, Shawn M., Mueller, Martina, Prudic, Joan, Greenberg, Robert M., Weiner, Richard D., Bailine, Samuel H., Riley, Mary Anne, McCloud, Laryssa, and Kellner, Charles H.

Published
2017
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12. More data on speed of remission with ECT in geriatric depression

Author

Kellner, Charles H., Geduldig, Emma T., Knapp, Rebecca G., Young, Robert C., Weiner, Richard D., Greenberg, Robert M., Prudic, Joan, McCall, W. Vaughn, Petrides, Georgios, Husain, Mustafa M., Rudorfer, Matthew V., and Lisanby, Sarah H.

Published
2015

15. Effect of concomitant pharmacotherapy on electroconvulsive therapy outcomes: short-term efficacy and adverse effects

Author

Sackeim, Harold A., Dillingham, Elaine M., Prudic, Joan, Cooper, Thomas, McCall, W. Vaughn, Rosenquist, Peter, Isenberg, Keith, Garcia, Keith, Mulsant, Benoit H., and Haskett, Roger F.

Subjects
Depression, Mental -- Care and treatment, Depression, Mental -- Patient outcomes, Drug resistance -- Care and treatment, Electroconvulsive therapy -- Usage, Electroconvulsive therapy -- Health aspects, Electroconvulsive therapy -- Patient outcomes, Antidepressants -- Usage, Antidepressants -- Health aspects, Health, Psychology and mental health
Published
2009

23. CORRESPONDENCE

Author

PRUDIC, JOAN, OLFSON, MARK, and SACKEIM, HAROLD A.

Published
2002

24. Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy

Author

Sackeim, Harold A., Prudic, Joan, Devanand, D.P., Kiersky, Judith E., Fitzsimons, Linda, Moody, Bobba J., McElhiney, Martin C., Coleman, Eliza A., and Settembrino, Joy M.

Subjects
Electroconvulsive therapy -- Methods, Depression, Mental -- Care and treatment
Abstract

Increasing the electrical dosage may improve the effectiveness of right unilateral electroconvulsive therapy. Electroconvulsive therapy is used to treat patients suffering from psychiatric disorders such as major depression. Among 96 patients suffering from depression, 23 were treated with right unilateral electroconvulsive therapy at a low dose, 23 with right unilateral electroconvulsive therapy at a high dose, 23 with bilateral electroconvulsive therapy at a low dose and 27 with bilateral electroconvulsive therapy at a high dose. Seventeen percent of the patients who received low-dose unilateral electroconvulsive therapy responded to treatment, compared with 43% of those who received high-dose unilateral therapy, 65% of those who received low-dose bilateral therapy and 63% of those who received high-dose bilateral therapy. Patients who received high-dose therapy improved faster than those who received low-dose therapy regardless of electrode placement.

Published
1993

30. Antidepressant Treatment History Form--Short Form

Author

Sackeim, Harold A., primary, Aaronson, Scott T., additional, Bunker, Mark T., additional, Conway, Charles R., additional, Demitrack, Mark A., additional, George, Mark S., additional, Prudic, Joan, additional, Thase, Michael E., additional, and Rushi, A. John, additional

Published
2019
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43. Relapse During Continuation Pharmacotherapy after Acute Response to ECT: A Comparison of Usual Care versus Protocolized Treatment

Author

Prudic Joan, James D. Tew, Roger F. Haskett, Amy E. Begley, Harold A. Sackeim, and Benoit H. Mulsant

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, medicine.medical_treatment, Nortriptyline, Antidepressive Agents, Tricyclic, Placebo, behavioral disciplines and activities, law.invention, Continuation, Electroconvulsive therapy, Pharmacotherapy, Lithium Carbonate, Randomized controlled trial, law, Secondary Prevention, Humans, Medicine, Combined Modality Therapy, Electroconvulsive Therapy, Psychiatry, Depression (differential diagnoses), Aged, Depressive Disorder, Major, business.industry, General Medicine, Middle Aged, Antidepressive Agents, Psychiatry and Mental health, Treatment Outcome, Drug Therapy, Combination, Female, business, Follow-Up Studies, medicine.drug
Abstract

Background. ECT, an effective treatment for major depression, is associated with a high relapse rate. Roughly half of all responders during the acute treatment phase relapse during continuation treatment. Recent literature has pointed out an “efficacy-effectiveness gap” in outcomes of patients enrolled in study protocols when compared to “care as usual.” This study compares the effectiveness of usual care versus protocolized pharmacotherapy in preventing relapse following ECT. Methods. One hundred twenty-six depressed patients responded to acute ECT. Seventy-three were randomized to continuation pharmacotherapy consisting of nortriptyline, nortriptyline-plus-lithium, or placebo. The 53 patients that refused to participate in the randomized trial were followed naturalistically for 6 months or until depression relapse in usual care settings. Results. All but one “usual care” patient received pharmacotherapy following ECT; 27 (51%) relapsed within 6 months. Only one usual care patient received continuation ECT as a first-line treatment. The “usual care” relapse rate was intermediate to the relapse rates of the patients receiving protocolized nortriptyline (60%) and nortriptyline-plus-lithium (39%), but superior to placebo (84%). Conclusions. The relapse rate associated with usual care following ECT was comparable to that of protocolized pharmacotherapy. This suggests that high relapse rates following ECT are not due solely to an “efficacy-effectiveness gap.”

Published
2007

45. Current electroconvulsive therapy practice and research in the geriatric population

Author

Kerner, Nancy Allison and Prudic, Joan

Subjects
Psychiatry, Electroconvulsive therapy, Geriatric psychiatry, mental disorders, behavioral disciplines and activities
Abstract

Electroconvulsive therapy (ECT) is utilized worldwide for various severe and treatment-resistant psychiatric disorders. Research studies have shown that ECT is the most effective and rapid treatment available for elderly patients with depression, bipolar disorder and psychosis. For patients who suffer from intractable catatonia and neuroleptic malignant syndrome, ECT can be life saving. For elderly patients who cannot tolerate or respond poorly to medications and who are at a high risk for drug-induced toxicity or toxic drug interactions, ECT is the safest treatment option. Organic causes are frequently associated with late-life onset of neuropsychiatric conditions, such as parkinsonism, dementia and stroke. ECT has proven to be efficacious even when these conditions are present. During the next decade, research studies should focus on the use of ECT as a synergistic therapy, to enhance other biological and psychological treatments, and prevent symptom relapse and recurrence.

Published
2014
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46. Electroconvulsive therapy in the continuation and maintenance treatment of depression: Systematic review and meta-analyses.

Author

Elias, Alby, Phutane, Vivek H., Clarke, Sandy, and Prudic, Joan

Subjects
ANTIDEPRESSANTS, MENTAL depression, THERAPEUTICS, DISEASE relapse prevention, CONFIDENCE intervals, ELECTROCONVULSIVE therapy, MEDICAL databases, INFORMATION storage & retrieval systems, MEDICAL information storage & retrieval systems, PSYCHOLOGY information storage & retrieval systems, MEDLINE, META-analysis, SYSTEMATIC reviews
Abstract

Objective: Acute course of electroconvulsive therapy is effective in inducing remission from depression, but recurrence rate is unacceptably high following termination of electroconvulsive therapy despite continued pharmacotherapy. Continuation electroconvulsive therapy and maintenance electroconvulsive therapy have been studied for their efficacy in preventing relapse and recurrence of depression. The purpose of this meta-analysis was to examine the efficacy of continuation electroconvulsive therapy and maintenance electroconvulsive therapy in preventing relapse and recurrence of depression in comparison to antidepressant pharmacotherapy alone. Methods: We searched MEDLINE, Embase, PsycINFO, clinicaltrials.gov and Cochrane register of controlled trials from the database inception to December 2016 without restriction on language or publication status for randomized trials of continuation electroconvulsive therapy and maintenance electroconvulsive therapy. Two independent Cochrane reviewers extracted the data in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews and meta-analyses. The risk of bias was assessed using four domains of the Cochrane Collaboration Risk of Bias Tool. Outcomes were pooled using random effect model. The primary outcome was relapse or recurrence of depression. Results: Five studies involving 436 patients were included in the meta-analysis. Analysis of the pooled data showed that continuation electroconvulsive therapy and maintenance electroconvulsive therapy, both with pharmacotherapy, were associated with significantly fewer relapses and recurrences than pharmacotherapy alone at 6 months and 1 year after a successful acute course of electroconvulsive therapy (risk ratio = 0.64, 95% confidence interval = [0.41, 0.98], p = 0.04, risk ratio = 0.46, 95% confidence interval = [0.21, 0.98], p = 0.05, respectively). There was insufficient data to perform a metaanalysis of stand-alone continuation electroconvulsive therapy or maintenance electroconvulsive therapy beyond 1 year. Conclusion: There are only a few randomized trials of continuation electroconvulsive therapy and maintenance electroconvulsive therapy. The preliminary and limited evidence suggests the modest efficacy of continuation electroconvulsive therapy and maintenance electroconvulsive therapy with concomitant pharmacotherapy in preventing relapse and recurrence of depressive episodes for 1 year after the remission of index episode with the acute course of electroconvulsive therapy. [ABSTRACT FROM AUTHOR]

Published
2018
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47. Effects of a Course of Right Unilateral Ultrabrief Pulse Electroconvulsive Therapy Combined With Venlafaxine on Insomnia Symptoms in Elderly Depressed Patients.

Author

McCall, W. Vaughn, Lisanby, Sarah H., Rosenquist, Peter B., Dooley, Mary, Husain, Mustafa M., Knapp, Rebecca G., Petrides, Georgios, Rudorfer, Matthew V., Young, Robert C., McClintock, Shawn M., Mueller, Martina, Prudic, Joan, Greenberg, Robert M., Weiner, Richard D., Bailine, Samuel H., Riley, Mary Anne, McCloud, Laryssa, and Kellner, Charles H.

Published
2018
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48. ECT Stimulus Parameters: Rethinking Dosage

Author

Peterchev, Angel V., Rosa, Moacyr A., Deng, Zhi-De, Prudic, Joan, and Lisanby, Sarah. H.

Subjects
Treatment Outcome, Neurobiology, Humans, Electroconvulsive Therapy, Evoked Potentials, Article
Abstract

In this article, we review the parameters that define the electroconvulsive therapy (ECT) electrical stimulus and discuss their biophysical roles. We also present the summary metrics of charge and energy that are conventionally used to describe the dose of ECT and the rules commonly deployed to individualize the dose for each patient. We then highlight the limitations of these summary metrics and dosing rules in that they do not adequately capture the roles of the distinct stimulus parameters. Specifically, there is strong theoretical and empirical evidence that stimulus parameters (pulse amplitude, shape, and width, and train frequency, directionality, polarity, and duration) exert unique neurobiological effects that are important for understanding ECT outcomes. Consideration of the distinct stimulus parameters, in conjunction with electrode placement, is central to further optimization of ECT dosing paradigms to improve the risk-benefit ratio. Indeed, manipulation of specific parameters, such as reduction of pulse width and increase in number of pulses, has already resulted in dramatic reduction of adverse effects, while maintaining efficacy. Furthermore, the manipulation of other parameters, such as current amplitude, which are commonly held at fixed, high values, might be productively examined as additional means of targeting and individualizing the stimulus, potentially reducing adverse effects. We recommend that ECT dose be defined using all stimulus parameters rather than a summary metric. All stimulus parameters should be noted in treatment records and published reports. To enable research on optimization of dosing paradigms, we suggest that ECT devices provide capabilities to adjust and display all stimulus parameters.

Published
2010

49. Speed of response to electroconvulsive therapy compared with ketamine

Author

Kellner, Charles H., primary, Lisanby, Sarah H., additional, Weiner, Richard, additional, Prudic, Joan, additional, Rudorfer, Matthew V., additional, Young, Robert C., additional, Petrides, George, additional, McCall, W. Vaughn, additional, Husain, Mustafa, additional, Greenberg, Robert M., additional, and Knapp, Rebecca G., additional

Published
2015
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