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436 results on '"Provincial Health Services Authority"'

1. Low-dose Naltrexone for Post-COVID Fatigue Syndrome

Author

BC Women's Hospital & Health Centre, University of British Columbia, Canadian Institutes of Health Research (CIHR), Provincial Health Services Authority, and Luis Nacul, Research Director, Complex Chronic Diseases Program, BC Women's Hospital + Health Centre/ Clinical Associate Professor, University of British Columbia

Published
2024

2. Canadian National PDA Treatment Study (CANRxPDA)

Author

Provincial Health Services Authority, Children's Hospital of Eastern Ontario, CHU de Quebec-Universite Laval, Foothills Medical Centre, Victoria General Hospital, The Hospital for Sick Children, Health Sciences Centre, Winnipeg, Manitoba, St. Justine's Hospital, Queen's University, MOUNT SINAI HOSPITAL, Royal Alexandra Hospital, Regina General Hospital, Royal University Hospital Foundation, St. Boniface Hospital, The Moncton Hospital, Horizon Health Network, Sunnybrook Health Sciences Centre, Windsor Regional Hospital, Royal Columbian Hospital, Centre de recherche du Centre hospitalier universitaire de Sherbrooke, London Health Sciences Centre, Canadian Institutes of Health Research (CIHR), and Dr. Souvik Mitra, MD MSc FRCPC, Assistant Professor

Published
2024

3. National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children

Author

Genome Canada, Genome British Columbia, Child and Family Research Institute, Western University, Canada, Provincial Health Services Authority, Health Canada, Canada Gene Cure, Eli Lilly and Company, Pfizer, Merck Sharp & Dohme LLC, Canadian Society of Clinical Pharmacology, Canadian Institutes of Health Research (CIHR), Canada Foundation for Innovation, British Columbia Clinical Genomics Network, and Bruce Carleton, Study Principal Investigator

Published
2024

4. Pain and Irritability in Non-Verbal Children (PIUO)

Author

Canadian Institutes of Health Research (CIHR), University of Calgary, University of Ottawa, Provincial Health Services Authority, Alberta Children's Hospital, Children's Hospital of Eastern Ontario, The Hospital for Sick Children, and Harold Siden, Dr.

Published
2024

5. Cisplatin Induced Kidney Toxicity (ACCENT)

Author

Canadian Institutes of Health Research (CIHR), London Health Sciences Centre, Provincial Health Services Authority, and Michael Zappitelli, Clinician Scientist

Published
2024

9. Appendectomy Versus Non-Operative Treatment For Acute Non-Perforated Appendicitis in Children (APPY)

Author

Provincial Health Services Authority, Alberta Children's Hospital, Children's Hospital of Western Ontario, St. Justine's Hospital, Children's Hospital of Winnipeg, Le Bonheur Children's Hospital, Karolinska University Hospital, Hospital for Children and Adolescents, Finland, University of Southampton, UCL Institute of Child Health, KK Women's and Children's Hospital, Uppsala University Children's Hospital, and Shawn St. Peter, Shawn St. Peter, MD, Director of Research, Department of Surgery

Published
2023

11. PRecIsion Medicine in CardiomyopathY (PRIMaCY)

Author

Stanford University, Children's Hospital of Philadelphia, New York Presbyterian Hospital, University of Texas Southwestern Medical Center, University of Michigan, Children's Hospital Medical Center, Cincinnati, Provincial Health Services Authority, Stollery Children's Hospital, Children's Hospital of Eastern Ontario, The Royal Children's Hospital Melbourne, Children's Healthcare of Atlanta, Primary Children's Hospital, Baylor College of Medicine, The Cleveland Clinic, Monroe Carell Jr. Children's Hospital at Vanderbilt, Children's Hospital Colorado, Indiana University Health, OHSU Doernbecher Children's Hospital, Children's Hospital Los Angeles, and Seema Mital, Principal Investigator

Published
2023

15. Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study

Author

University of Calgary, University of Saskatchewan, Centre for Addiction and Mental Health, University of British Columbia, Memorial University of Newfoundland, University of Alberta, St. Justine's Hospital, McMaster Children's Hospital, Dalhousie University, Montreal Children's Hospital of the MUHC, Children's Hospital of Eastern Ontario, Provincial Health Services Authority, Seattle Children's Hospital, University Health Network, Toronto, London Health Sciences Centre, Quebec Pain Research Network, and Jennifer Stinson, Senior Scientist

Published
2023

17. Coached, Coordinated, Enhanced Neonatal Transition (CCENT) (CCENT)

Author

Sunnybrook Health Sciences Centre, Children's Hospital of Eastern Ontario, MOUNT SINAI HOSPITAL, The Ottawa Hospital, Montreal Children's Hospital of the MUHC, Provincial Health Services Authority, and Julia Orkin, Staff Physician, Medical Director of the Complex Care Program

Published
2023

18. CT18 Infant Influenza Priming Study in Vaccine Naive Infants

Author

Provincial Health Services Authority, McGill University Health Centre/Research Institute of the McGill University Health Centre, Université de Montréal, Canadian Center for Vaccinology, CHU de Quebec-Universite Laval, Dalhousie University, and Joanne Langley, Principal Investigator

Published
2023

20. CNTRP POSITIVE Study

Author

Canadian Institutes of Health Research (CIHR), Alberta Children's Hospital, Stollery Children's Hospital, St. Justine's Hospital, The Children's Hospital of Winnipeg, Montreal Children's Hospital of the MUHC, Provincial Health Services Authority, Toronto General Hospital, Vancouver General Hospital, Royal Victoria Hospital, Canada, The Ottawa Hospital, Foothills Medical Centre, Centre hospitalier de l'Université de Montréal (CHUM), University of British Columbia, and Seema Mital, Staff Cardiologist

Published
2021

21. The Treatment of Type I Open Fractures in Pediatrics (PROOF)

Author

Provincial Health Services Authority, University of Mississippi Medical Center, MultiCare Mary Bridge Children's Hospital & Health Center, Yale New Haven Health System Center for Healthcare Solutions, University of New Mexico Carrie Tingley Hospital, IWK Health Centre, Phoenix Children's Hospital, Children's Hospital Colorado, Nationwide Children's Hospital, Morristown Medical Center, NYUMC-Hospital for Joint Diseases, Children's Medical Center Dallas, Johns Hopkins University, Orthopaedic Institute for Children, Children's Hospital Los Angeles, St. Christopher's Hospital for Children, and Joseph Janicki, MD, Assistant Professor of Pediatrics, Northwestern University Feinberg School of Medicine

Published
2021

25. Long-Term Outcomes of Hip Interventions for Children With Cerebral Palsy (CHOP II)

Author

Royal Children's Hospital, Shriners Hospitals for Children,Canada, Provincial Health Services Authority, Aarhus University Hospital, Sheba Medical Center, Seoul National University Bundang Hospital, Starship Children's Hospital of New Zealand, Poznan University of Medical Sciences, Skane University Hospital, Karolinska University Hospital, Great Ormond Street Hospital for Children NHS Foundation Trust, The Royal London Hospital, Nuffield Orthopaedic Centre NHS Trust, Children's Hospital Medical Center, Cincinnati, Boston Children's Hospital, Columbia University, Shriners Hospitals for Children, Sacramento, Gillette Children's Specialty Healthcare, Alfred I. duPont Hospital for Children, IWK Health Centre, Alder Hey Children's NHS Foundation Trust, Children's Hospital Colorado, Hospital for Special Surgery, New York, Shriners Hospitals for Children, Honolulu, Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust, Morgan Stanley Children's Hospital, Children's Health Queensland Hospital and Health Service, University of Nebraska, and Unni Narayanan, MBBS, MSc, FRSC(C)

Published
2021

26. Canadian CP Registry - Registre Canadien de la Paralysie Cérébrale

Author

Kids Brain Health Network, Children's Treatment Network, Montreal Children's Hospital of the MUHC, Alberta Children's Hospital, Women and Children's Health Research Institute, Canada, Provincial Health Services Authority, IWK Health Centre, The Hospital for Sick Children, Holland Bloorview Kids Rehabilitation Hospital, and Maryam Oskoui, MD, MSc, FRCPC, FAAN, Associate Professor, Departments of Pediatrics and Neurology & Neurosurgery

Published
2021

27. Registry of Unexplained Cardiac Arrest

Author

Queen's University, Quebec Heart Institute, The Queen Elizabeth Hospital, St. Boniface Hospital, Unity Health Toronto, Vancouver Island Health Authority, Provincial Health Services Authority, Montreal Heart Institute, Ottawa Heart Institute Research Corporation, University of Calgary, and Andrew Krahn, Principal Iinvestigator

Published
2020

29. Evaluating the Effectiveness of the Dissemination of Action Schools! BC (AS!BC)

Author

University of Victoria, University of Waterloo, Canadian Institutes of Health Research (CIHR), Heart and Stroke Foundation of Canada, Ministry of Education, British Columbia, Ministry of Health, British Columbia, Ministry of Tourism, Sport and the Arts, British Columbia, Provincial Health Services Authority, JW Sporta, 2010 Legacies Now, and Heather McKay, Principal Investigator

Published
2019

31. Jointly Managing JIA Online: An Internet-based Psycho-educational Game for Children With JIA and Their Parents

Author

Provincial Health Services Authority, Alberta Children's Hospital, Montreal Children's Hospital of the MUHC, IWK Health Centre, Children's Hospital of Eastern Ontario, St. Justine's Hospital, University of Toronto, McGill University, University of Florida, Children's Hospital of Western Ontario, University of Kansas Medical Center, Memorial University of Newfoundland, and Jennifer Stinson, Clinician Scientist/Clinical Nurse Specialist/NP

Published
2019

38. How Safe Are Our Pediatric Emergency Departments?

Author

Provincial Health Services Authority, Stollery Children's Hospital, Alberta Children's Hospital, The Children's Hospital of Winnipeg, London Health Sciences Centre, The Hospital for Sick Children, St. Justine's Hospital, Janeway Children's Health and Rehabilitation Centre, Manitoba Institute of Child Health, Ottawa Hospital Research Institute, and Amy Plint, Senior Scientist, CHEO Research Institute; Physician, Division of Emergency Medicine

Published
2018

42. The Transcription Factor Encyclopedia

Author

Yusuf, Dimas, Butland, Stefanie L., Swanson, Magdalena I., Bolotin, Eugene, Ticoll, Amy, Cheung, Warren A., Zhang, Xiao Yu Cindy, Dickman, Christopher T. D., Fulton, Debra L., Lim, Jonathan S., Schnabl, Jake M., Ramos, Oscar H. P., Vasseur-Cognet, Mireille, de Leeuw, Charles N., Simpson, Elizabeth M., Ryffel, Gerhart U., Lam, Eric W.-F., Kist, Ralf, Wilson, Miranda S. C., Marco-Ferreres, Raquel, Brosens, Jan J., Beccari, Leonardo L., Bovolenta, Paola, Benayoun, Bérénice A., Monteiro, Lara J, Schwenen, Helma D C, Grontved, Lars, Wederell, Elizabeth, Mandrup, Susanne, Veitia, Reiner A, Chakravarthy, Harini, Hoodless, Pamela A., Mancarelli, M Michela, Torbett, Bruce E, Banham, Alison H, Reddy, Sekhar P, Cullum, Rebecca L, Liedtke, Michaela, Tschan, Mario P, Vaz, Michelle, Rizzino, Angie, Zannini, Mariastella, Frietze, Seth, Farnham, Peggy J, Eijkelenboom, Astrid, Brown, Philip J, Laperrière, David, Leprince, Dominique, de Cristofaro, Tiziana, Prince, Kelly L, Putker, Marrit, del Peso, Luis, Camenisch, Gieri, Wenger, Roland H, Mikula, Michal, Rozendaal, Marieke, Mader, Sylvie, Ostrowski, Jerzy, Rhodes, Simon J, Van Rechem, Capucine, Boulay, Gaylor, Olechnowicz, Sam W Z, Breslin, Mary B, Lan, Michael S, Nanan, Kyster K, Wegner, Michael, Hou, Juan, Mullen, Rachel D, Colvin, Stephanie C, Noy, Peter John, Webb, Carol F, Witek, Matthew E, Ferrell, Scott, Daniel, Juliet M, Park, Jason, Waldman, Scott A, Peet, Daniel J, Taggart, Michael, Jayaraman, Padma-Sheela, Karrich, Julien J, Blom, Bianca, Vesuna, Farhad, O'Geen, Henriette, Sun, Yunfu, Gronostajski, Richard M, Woodcroft, Mark W, Hough, Margaret R, Chen, Edwin, Europe-Finner, G Nicholas, Karolczak-Bayatti, Magdalena, Bailey, Jarrod, Hankinson, Oliver, Raman, Venu, LeBrun, David P, Biswal, Shyam, Harvey, Christopher J, DeBruyne, Jason P, Hogenesch, John B, Hevner, Robert F, Héligon, Christophe, Luo, Xin M, Blank, Marissa Cathleen, Millen, Kathleen Joyce, Sharlin, David S, Forrest, Douglas, Dahlman-Wright, Karin, Zhao, Chunyan, Mishima, Yuriko, Sinha, Satrajit, Chakrabarti, Rumela, Portales-Casamar, Elodie, Sladek, Frances M, Bradley, Philip H, Wasserman, Wyeth W, Cindy Zhang, Xiao, Department of Medical Genetics, Faculty of Medicine-Child and Family Research Institute-Centre for Molecular Medicine and Therapeutics-University of British Columbia (UBC), Evaluation and Research Services, Fraser Health Authority, Children's Hospital Oakland, Oakland Research Institute, Computational Biology Program, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Department of Bioinformatics, Child and Family Research Institute-Centre for Molecular Medicine and Therapeutics-University of British Columbia (UBC), Department of Biology, University of Western Ontario (UWO), Genetics Program, Department of Cell Biology and Neuroscience [Riverside] (CBNS), University of California [Riverside] (UC Riverside), University of California (UC)-University of California (UC), Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) (SIMoS), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut für Zellbiologie, Universität Duisburg-Essen [Essen]-Universitätsklinikum Essen, Department of Surgery and Cancer, Imperial College London-Division of Cancer, Centre for Oral Health Research, Newcastle University [Newcastle]-Medical School-School of Dental Sciences, Department of Development and Differentiation, Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-CIBER de Enfermedades Raras (CIBERER), Division of Reproductive Health, University of Warwick [Coventry]-Warwick Medical School, University of Warwick [Coventry], Neurobiologia Molecular Celular y del desarrollo, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU), Terry Fox Laboratory, BC Cancer Agency (BCCRC)-Provincial Health Services Authority, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, University of Nebraska System-University of Nebraska System, Department of Molecular Experimental Medicine, The Scripps Research Institute [La Jolla, San Diego], Departments of Molecular and Experimental Medicine and Immunology and Microbial Sciences (MEM 131), Nuffield Department of Clinical Laboratory Sciences, University of Oxford- John Radcliffe Hospital [Oxford University Hospital]-Oxford NIHR Biomedical Research Centre, Department of Pediatrics, College of Medicine-Department of pediatrics-University of Illinois [Chicago] (UIC), University of Illinois System-University of Illinois System, Division of Hematology [Stanford], Stanford Medicine, Stanford University-Stanford University, Department of Medicine, University of Bern, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine [Baltimore]-Johns Hopkins University School of Medicine [Baltimore]-Johns Hopkins University School of Medicine, Institute of Experimental Endocrinology and Oncology (IEOS), Consiglio Nazionale delle Ricerche (CNR), University of Southern California (USC)-Norris Comprehensive Cancer Center, Department of Molecular Cancer Research, University Medical Center [Utrecht]-Utrecht University [Utrecht], University of Oxford- John Radcliffe Hospital [Oxford University Hospital]-Medical Sciences Division, Molecular Targeting in Breast Cancer research unit, Institut de Recherche en Immunologie et en Cancérologie [UdeM-Montréal] (IRIC), Université de Montréal (UdeM)-Université de Montréal (UdeM), Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indiana University System-Indiana University System, Department of Physiological Chemistry, Department of Biochemistry, Universidad Autónoma de Madrid (UAM)-School of Medicine, Institute of Physiology, Universität Zürich [Zürich] = University of Zurich (UZH)-Zurich Center for Integrative Human Physiology, Department of Oncological Genetics, Institute of Oncology-Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC)-Medical Center of Postgraduate Education [Warsaw] (MCPE), Indiana University [Bloomington], Indiana University System-Indiana University System-School of Science, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston]-Cancer Center, University of Adelaide-School of Molecular and Biomedical Science, Department of Pediatrics and Biochemistry and Molecular Biology, Louisiana State University (LSU)-Research Institute for Children-Children's Hospital at New Orleans, Departments of Pediatrics and Genetics, Department of Pathology and Molecular Medicine, Queen's University [Kingston, Canada]-Queen's Cancer Research Institute, School of Medicine [Erlangen], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Institut fuer Biochemie-Emil-Fischer-Zentrum, Department of Molecular Biology and Biochemistry, University Indianapolis-Indiana University School of Medicine, Department of Immunity and Infection, School of Medical and Dental Sciences-University of Birmingham [Birmingham], Immunobiology and Cancer Program, Oklahoma Medical Research Foundation (OMRF), Radiation Oncology, Department of Pharmacology and Experimental Therapeutics-Jefferson University Hospitals, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center (OUHSC), McMaster University [Hamilton, Ontario], School of Medicine, Johns Hopkins University (JHU), Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University-Jefferson Medical College, Discipline of Biochemistry, Institute of Cellular Medicine, Newcastle University [Newcastle]-Faculty of Medicine-Medical School, Department of Immunity and Immunology, Department of Cell Biology and Histology, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA)-Center for Immunology Amsterdam, Division of Cancer Imaging Research, Johns Hopkins University (JHU)-School of Medicine-Department of Radiology, Genome Center [UC Davis], University of California [Davis] (UC Davis), School of Biological Sciences [Univ California San Diego] (UC San Diego), University of California [San Diego] (UC San Diego), Department of Biochemistry and Developmental Genomics Group, University at Buffalo [SUNY] (SUNY Buffalo), State University of New York (SUNY)-State University of New York (SUNY)-Center of Excellence in Bioinformatics and Life Sciences, Department of Molecular and Cellular Biology, University of Toronto-Sunnybrook Health Sciences Centre-Department of Laboratory Medicine and Pathobiology, Faculty of Medical Sciences, Newcastle University [Newcastle]-Medical School-Institute of Cellular Medicine, Department of Pathology and Laboratory Medicine, University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC)-David Geffen School of Medicine [Los Angeles], Radiology and Oncology, Johns Hopkins University (JHU)-School of Medicine, Department of Environmental Health Sciences, Johns Hopkins University (JHU)-Johns Hopkins Bloomberg School of Public Health [Baltimore], Department of Pharmacology and Toxicology, Neuroscience Institute-Morehouse School of Medicine, Department of Pharmacology, University of Pennsylvania-Perelman School of Medicine, University of Pennsylvania, Department of Neurological Surgery, University of Washington [Seattle]-Seattle Children's Research Institute, Faculty of Biology and Medicine, Université de Lausanne = University of Lausanne (UNIL)-Center for Integrated Genomics, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University [Blacksburg]-Virginia-Maryland College of Veterinary Medicine, Department of Molecular Genetics and Cell Biology, University of Illinois [Chicago] (UIC), Center for Integrative Brain Research, University of Washington [Seattle], Clinical Endocrinology Branch, National Institutes of Health (NIH)-National Institute of Diabetes, Digestive, and Kidney Disorders, Department of Biosciences and Nutrition, Karolinska Institutet [Stockholm], State University of New York (SUNY)-State University of New York (SUNY), BMC, Ed., Universität Duisburg-Essen = University of Duisburg-Essen [Essen]-Universitätsklinikum Essen, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), UAM. Departamento de Bioquímica, Faculty of Medicine-Child and Family Research Institute-Centre for Molecular Medicine and Therapeutics-University of British Columbia ( UBC ), Fred Hutchinson Cancer Research Center [Seattle] ( FHCRC ) -Public Health Sciences Division, Child and Family Research Institute-Centre for Molecular Medicine and Therapeutics-University of British Columbia ( UBC ), University of Western Ontario ( UWO ), Department of Cell Biology and Neuroscience [Riverside] ( CBNS ), University of California [Riverside] ( UCR ), Service d'Ingénierie Moléculaire des Protéines ( SIMOPRO ), Département Médicaments et Technologies pour la Santé ( DMTS ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), CIBER de Enfermedades Raras (CIBERER)-Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ) -Centro de Biologia Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ) -Centro de Biologia Molecular Severo Ochoa (CBMSO)-CIBER de Enfermedades Raras (CIBERER), Service de Pathologies moléculaire et cellulaire, Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), UNIVERSITY OF SOUTHERN DENMARK, BC Cancer Agency ( BCCRC ) -Provincial Health Services Authority, Scripps Research Institute, Departments of Molecular and Experimental Medicine and Immunology and Microbial Sciences ( MEM 131 ), University of Oxford [Oxford]- John Radcliffe Hospital [Oxford University Hospital]-Oxford NIHR Biomedical Research Centre, College of Medicine-Department of pediatrics-University of Illinois at Chicago ( UIC ), Department of Medicine/Hematology, Stanford University School of Medicine, Institute of Experimental Endocrinology and Oncology ( IEOS ), CNR - National Research Council, University of Southern California ( USC ) -Norris Comprehensive Cancer Center, Utrecht University [Utrecht]-University Medical Center Utrecht, University of Oxford [Oxford]- John Radcliffe Hospital [Oxford University Hospital]-Medical Sciences Division, Université de Montréal-Institute for Research in Immunology and Cancer, Institut de biologie de Lille - IBL ( IBLI ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Lille, Droit et Santé, Utrecht University [Utrecht]-University Medical Centre Utrecht, Universidad Autonoma de Madrid ( UAM ) -School of Medicine, University of Zürich [Zürich] ( UZH ) -Zurich Center for Integrative Human Physiology, Institute of Oncology-Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology ( MCMCC ) -Medical Center of Postgraduate Education [Warsaw] ( MCPE ), Indiana University [Bloomington]-School of Science, Harvard Medical School [Boston] ( HMS ) -Cancer Center-Massachusetts General Hospital, Louisiana State University Health Sciences Center-Research Institute for Children-Children's Hospital at New Orleans, Queen's University [Kingston]-Queen's Cancer Research Institute, Institut fuer Biochemie-Emil-Fischer-Zentrum-Friedrich-Alexander Universitaet Erlangen-Nuernberg, Indiana University School of Medicine-University Indianapolis, Oklahoma Medical Research Foundation, Department of Pharmacology and Experimental Therapeutics-Jefferson University Hospital, University of Oklahoma Health Sciences Center ( OUHSC ), Johns Hopkins University ( JHU ), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ) -University of Amsterdam [Amsterdam] ( UvA ) -Center for Immunology Amsterdam, Johns Hopkins University ( JHU ) -School of Medicine-Department of Radiology, University of California at Davis, Division of Biological Sciences [San Diego], University of California [San Diego] ( UC San Diego ), State University of New York at Buffalo ( SUNY Buffalo ) -Center of Excellence in Bioinformatics and Life Sciences, University of California at Los Angeles [Los Angeles] ( UCLA ) -David Geffen School of Medicine, Johns Hopkins University ( JHU ) -School of Medicine, Johns Hopkins University ( JHU ) -Johns Hopkins Bloomberg School of Public Health, University of Pennsylvania [Philadelphia]-Perelman School of Medicine, University of Lausanne-Center for Integrated Genomics, Virginia Polytechnic Institute and State University [Blacksburg]-VA-MD Regional College of Veterinary Medicine, University of Illinois at Chicago ( UIC ), State University of New York at Buffalo ( SUNY Buffalo ) -University of Buffalo School of Medicine and Biomedical Sciences, University of California [Riverside] (UCR), University of California-University of California, Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-CIBER de Enfermedades Raras (CIBERER), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Johns Hopkins University School of Medicine-The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine [Baltimore]-Johns Hopkins University School of Medicine [Baltimore], Utrecht University [Utrecht]-University Medical Center [Utrecht], Universidad Autonoma de Madrid (UAM)-School of Medicine, Cancer Center-Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Emil-Fischer-Zentrum-Institut fuer Biochemie, School of Molecular and Biomedical Science-University of Adelaide, School of Medicine-Department of Radiology-Johns Hopkins University (JHU), University of California-University of California-David Geffen School of Medicine [Los Angeles], Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU)-Johns Hopkins University (JHU), University of Pennsylvania [Philadelphia], Université de Lausanne (UNIL)-Center for Integrated Genomics, AII - Amsterdam institute for Infection and Immunity, and Cell Biology and Histology

Subjects
Encyclopedias as Topic, INFORMATION, WIKI, Transcription, Genetic, 05 Environmental Sciences, Medizin, [SDV.GEN] Life Sciences [q-bio]/Genetics, Automate Content, Web API, ANNOTATION, Mini review, Mice, 0302 clinical medicine, Portable Document Format, GENETICS & HEREDITY, Databases, Protein, Informática, 0303 health sciences, PROTEIN DATA-BANK, Application programming interface, BIOTECHNOLOGY & APPLIED MICROBIOLOGY, MENDELIAN-INHERITANCE, ddc:57, [ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], 030220 oncology & carcinogenesis, Application Programming Interface, Encyclopedia, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], The Internet, Transcription (software), Transcription, Life Sciences & Biomedicine, KNOWLEDGEBASE, Medicina, DATABASE, Bioinformatics, Biology, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Zellbiologie (Tumorforschung), World Wide Web, Access to Information, 03 medical and health sciences, Databases, Genetic, Protein Data Bank, ddc:570, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], ddc:61, Animals, Humans, ddc:610, MeSH Term, Transcription factor, 030304 developmental biology, Internet, 08 Information And Computing Sciences, [SDV.GEN]Life Sciences [q-bio]/Genetics, Science & Technology, GENE-REGULATION, business.industry, Protein, Computational Biology, 06 Biological Sciences, Compendium, EVOLUTION, Rats, Evolutionary biology, UPDATE, business, [ SDV.GEN ] Life Sciences [q-bio]/Genetics, Software, Transcription Factors
Abstract

Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130 mini review articles on pertinent human, mouse and rat TFs. Notable features of the TFe website include a high-quality PDF generator and web API for programmatic data retrieval. TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe.

Published
2012

43. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries

Author

Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M, Schulze, Matthias B, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda MA, Verschuren, WM Monique, van der Schouw, Yvonne T, Skeie, Guri, Braaten, Tonje, Redondo, M Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J, Forouhi, Nita G, Vineis, Paolo, Tsilidis, Konstantinos K, Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, Touvier, Mathilde, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Réseau National Alimentation Cancer Recherche (réseau NACRe), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Département de Santé Publique [Avicenne], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), School of Public Health, Imperial College London, Aarhus University [Aarhus], Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Danish Cancer Society Research Center, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Institute of Nutrition Science, University of Potsdam, Hellenic Health Foundation, 'Attikon' University Hospital, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], AOU Federico II, Partenaires INRAE, Provincial Health Services Authority, Center for Cancer Prevention (CPO-Piemonte), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], The Arctic University of Norway (UiT), Public Health Directorate, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Andalusian School of Public Health [Granada], Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Granada, Spain, parent, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Council [Murcia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Navarra Public Health Institute, Navarra Institute for Health Research, Biodonostia Health Research Institute, Department of Clinical Sciences [Malmö, Suède], Lund University [Malmö, Suède], Department of Public Health and Clinical Medicine [Umeå, Sweden] (Environmental and Occupational Medicine), Umeå University, University of Cambridge School of Clinical Medicine, University of Ioannina School of Medicine, Nuffield Department of Population Health [Oxford], University of Oxford [Oxford], French National Cancer Institute (INCa)-Canceropole Ile-de-France 2017-1-PL SHS-01-INSERM ADR 5-1Fondation Recherche Medicale ARF201809007046European CommissionEuropean Commission Joint Research CentreInternational Agency for Research on CancerDanish Cancer SocietyLigue nationale contre le cancerInstitut Gustave RoussyMutuelle Generale de l'Education NationaleInstitut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeFederal Ministry of Education & Research (BMBF)Hellenic Health Foundation (Greece)Associazione Italiana per la Ricerca sul Cancro (AIRC)Italian National Research CouncilDutch Ministry of Public Health, Welfare, and Sports (the Netherlands)Netherlands Cancer Registry (the Netherlands)Netherlands GovernmentHealth Research Fund (Spain)Instituto de Salud Carlos IIIJunta de Andalucia Regional government of Asturias (Spain) Regional government of Basque Country (Spain) Regional government of Murcia (Spain) Regional government of Navarra (Spain) Catalan Institute of Oncology (Spain)Swedish Cancer Society Swedish Scientific Council (Sweden) County councils of Skane and Vasterbotten (Sweden)Cancer Research UK C864/A14136 C8221/A19170Medical Research Council UK (MRC) MR/N003284/1 - MC-UU_12015/1 - MR/M012190/1 - MC_UU_12015/1 - MC_UU_12015/5 - National Institute for Health Research Biomedical Research Centre, Cambridge: Nutrition, Diet, and Lifestyle Research Theme IS-BRC-1215-20014, Deschasaux, Mélanie [0000-0002-3359-420X], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, 1117 Public Health and Health Services, Cohort Studies, Food Preferences, Food Labeling, General & Internal Medicine, Surveys and Questionnaires, Mortalitat, Humans, Mortality, Nutrició, ComputingMilieux_MISCELLANEOUS, Nutrition, Proportional Hazards Models, Research, Klinisk medicin, 1103 Clinical Sciences, Middle Aged, Europe, Nutrition Assessment, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Clinical Medicine, Nutritive Value, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Objective: To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design: Population based cohort study. Setting: European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants: 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure: Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results: After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, PConclusions: In this large multinational European cohort, consuming foods with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher mortality for all causes and for cancer and diseases of the circulatory, respiratory, and digestive systems, supporting the relevance of FSAm-NPS to characterise healthier food choices in the context of public health policies (eg, the Nutri-Score) for European populations. This is important considering ongoing discussions about the potential implementation of a unique nutrition labelling system at the European Union level.

Published
2020

44. Left-Dominant Temporal-Frontal Hypercoupling in Schizophrenia Patients With Hallucinations During Speech Perception

Author

Hélène Lœvenbruck, Kwanghee Jung, Todd S. Woodward, Jennifer C. Whitman, Paul D. Metzak, Lucile Rapin, Marion Dohen, Katie M. Lavigne, Department of Psychiatry, University of British Columbia (UBC), BC Mental Health and Addictions Research Institute, Provincial Health Services Authority, Vancouver, BC, Canada, Department of Linguistics, Université du Québec à Montréal = University of Québec in Montréal (UQAM), Department of Pediatrics, The University of Texas Health Science Center at Houston (UTHealth), GIPSA - Perception, Contrôle, Multimodalité et Dynamiques de la parole (GIPSA-PCMD), Département Parole et Cognition (GIPSA-DPC), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Langage, Laboratoire de Psychologie et NeuroCognition (LPNC), Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Explora'Doc région Rhône-Alpes - Michael Smith Foundation for Health Research (MSFHR) - Canadian Institutes of Health Research (CIHR) - Mind Foundation of British Columbia, Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), and Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)

Subjects
Adult, Male, Elementary cognitive task, medicine.medical_specialty, Bipolar Disorder, Speech perception, Hallucinations, Brain activity and meditation, [SHS.PSY]Humanities and Social Sciences/Psychology, Audiology, Brain mapping, behavioral disciplines and activities, speech perception, Functional Laterality, Young Adult, inner speech, Functional neuroimaging, Neural Pathways, medicine, Humans, Brain Mapping, medicine.diagnostic_test, Functional Neuroimaging, [SCCO.NEUR]Cognitive science/Neuroscience, functional connectivity, Brain, Regular Article, Middle Aged, [SCCO.LING]Cognitive science/Linguistics, medicine.disease, Magnetic Resonance Imaging, functional magnetic resonance imaging, Temporal Lobe, Frontal Lobe, schizophrenia, Psychiatry and Mental health, Hallucinating, Schizophrenia, Case-Control Studies, Female, Schizophrenic Psychology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, Functional magnetic resonance imaging, Cognitive psychology
Abstract

International audience; Background: Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. Methods: In the current study, we used a task that allowed experimental manipulation of control over verbal material and compared brain activity between 23 schizophrenia patients (10 hallucinators, 13 nonhallucinators), 22 psychiatric (bipolar), and 27 healthy controls. Two conditions were presented, one involving inner verbal thought (in which control over verbal material was required) and another involving speech perception (SP; in which control verbal material was not required). Results: A functional connectivity analysis resulted in a left-dominant temporal-frontal network that included speech-related auditory and motor regions and showed hypercoupling in past-week hallucinating schizophrenia patients (relative to nonhallucinating patients) during SP only. Conclusions: These findings replicate our previous work showing generalized speech-related functional network hypercoupling in schizophrenia during inner verbal thought and SP, but extend them by suggesting that hypercoupling is related to past-week hallucination severity scores during SP only, when control over verbal material is not required. This result opens the possibility that practicing control over inner verbal thought processes may decrease the likelihood or severity of hallucinations.

Published
2015

45. Population perinatal substance use and an environmental scan of health services in British Columbia, Canada.

Author

Piske M, Joyce S, Yan Y, Katsuno N, Homayra F, Zanette MJ, Barker B, Meilleur L, McBride B, Joshi P, Sullivan E, and Nosyk B

Subjects
Humans, British Columbia epidemiology, Female, Pregnancy, Retrospective Studies, Adult, Pregnancy Complications epidemiology, Perinatal Care trends, Perinatal Care methods, Young Adult, Health Services Accessibility, Cohort Studies, Rural Population, Substance-Related Disorders epidemiology
Abstract

Background: Substance use during pregnancy is underreported globally and there is limited data on its prevalence and the availability of supportive services. This study determined population perinatal substance use in British Columbia (BC) by region and examined the availability of clinical and community-based programs., Methods: Using linked provincial health administrative data, we conducted a population-based retrospective cohort study including all BC residents accessing care for substance use (alcohol, opioids, stimulants, sedatives, and cannabis) within 12 months of first perinatal care record to delivery during 2016-2021. We also conducted an environmental scan to identify all programs offering perinatal care and substance use treatment/support in BC as of December 2022 and described program components by region., Results: The population included 12,439 people with perinatal substance use with 13,814 linked livebirths during the study period. The incidence rate of perinatal substance use was nearly eight times higher in rural/remote Northern BC compared to the metropolitan Vancouver Coastal region (1044.2 vs. 131.3 per 100,000 population, respectively). We identified 29 related services (19 wrap-around programs, 8 supportive housing, and only 2 acute care programs). Residents outside of Metro Vancouver accounted for 60 % (N=1745) of people with perinatal substance use; however, these regions represented only 35 % of BC's specialized acute care and supportive housing beds (N=140)., Conclusions: Expanding supports for perinatal substance use - particularly acute care and supportive housing within more rural/remote regions in BC - will be critical to address geographic inequities in access to perinatal care and improve health outcomes for pregnant people who use substances and their infants., Competing Interests: Declaration of Competing Interest No conflict declared., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2024
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46. Deploying an ethics needs assessment to inform a navigational tool for research compliance pathways at a provincial Canadian health authority.

Author

Fung E, Portales-Casamar E, Kadam P, and Longstaff H

Subjects
Humans, British Columbia, Ethics Committees, Research standards, Ethics Committees, Research organization & administration, Ethics, Research, Guideline Adherence standards, Needs Assessment
Abstract

Practitioners aim to improve healthcare systems and clinical care through a variety of activities as part of a learning healthcare system. Yet the distinction between projects requiring Research Ethics Board (REB) approval or not is becoming increasingly blurred, making it difficult for researchers and others to classify projects and then navigate the required compliance pathway appropriately. To address this challenge, the Provincial Health Services Authority (PHSA) of British Columbia (BC) created a decision tool called the "PHSA Project Sorter Tool" to serve its diverse community while also meeting the unique needs of the BC regulatory and policy environment. The goal of the tool was to standardize and clarify organizational project review and ensure project leads were referred to the appropriate review body or service provider within the PHSA in the most efficient manner possible. In this paper, we describe the ethics needs assessment that was conducted to inform the tool and the results of our ongoing evaluation of the tool since it was launched in January, 2020. Our project shows that this simple tool can reduce burdens on staff and provide clarity to users by standardizing processes and terms and directing users to appropriate internal resources.

Published
2024
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47. Caregiver and Youth Characteristics That Influence Trust in Digital Health Platforms in Pediatric Care: Mixed Methods Study.

Author

Chow E, Virani A, Pinkney S, Abdulhussein FS, van Rooij T, Görges M, Wasserman W, Bone J, Longstaff H, and Amed S

Subjects
Humans, Adolescent, Female, Male, Child, Adult, Canada, Middle Aged, United States, Surveys and Questionnaires, Pediatrics methods, Information Dissemination methods, Digital Health, Caregivers psychology, Trust
Abstract

Background: Combining patient-generated health data and digital health platforms may improve patient experience and population health, mitigate rising health care costs, reduce clinician burnout, and enable health equity. However, lack of trust may be a notable barrier to the data-sharing required by such platforms. Understanding sociodemographic, health, and personal characteristics will enable developers and implementers of such technologies to consider these in their technical design requirements., Objective: This study aims to understand relationships between sociodemographic characteristics of caregivers of children or adolescents and trust in and willingness to use digital platforms to store and share personal health information for clinical care and research., Methods: This study used a mixed methods approach, including surveys of caregivers of youth aged <18 years living in Canada or the United States and youth aged 16 to 17 years living in Canada, as well as web-based bulletin board discussions to further explore topics of trust in data sharing. Sociodemographic and survey data were tabulated and explored using proportional odds ordinal regression models. Comments from web-based group discussions were analyzed thematically using a coding approach to identify issues important to the participants., Results: Survey data from 1128 caregivers (female participants: n=549, 48.7%; 36-50 years old: n=660, 58.5%; Canadian: n=603, 53.5%; urban population: n=494, 43.8%) were collected, of which 685 (60.7%) completed all questions. Data from 173 youth (female participants: n=73, 42.2%; urban population: n=94, 54.3%) were collected, of which 129 (74.6%) completed all questions, and data were available for analysis. Furthermore, among 40 participants, 23 (58%) caregivers contributed to the web-based discussion boards. Related to trust, living in a rural area (vs urban; odds ratio [OR] 0.66, 95% CI 0.46-0.95) resulted in lower concern for data privacy and security, while having an undergraduate (OR 1.82, 95% CI 1.30-2.55) or graduate degree (vs secondary or trade school; OR 2.50, 95% CI 1.68-3.73) resulted in higher levels of concern. Living with a chronic disease (OR 1.81, 95% CI 1.35-2.44) increased levels of concern regarding data privacy and security. Interestingly, those with chronic disease were more willing to use digital platforms for clinical care and share personal health information for not-for-profit research. Caregivers were most concerned about data breaches involving data from their children but also highlighted that digital platforms would allow for better coordination of care for their children., Conclusions: Our research confirms the willingness of caregivers and youth to use digital platforms for both clinical care delivery and research and suggests that the value of a digital platform may outweigh the risks of its use. Engagement of end users in co-designing such platforms has the potential to enhance digital trust. However, digital trust varies across sociodemographic groups; therefore, diverse end user engagement is necessary when designing digital applications., (©Eric Chow, Alice Virani, Susan Pinkney, Fatema S Abdulhussein, Tibor van Rooij, Matthias Görges, Wyeth Wasserman, Jeffrey Bone, Holly Longstaff, Shazhan Amed. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 28.10.2024.)

Published
2024
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48. Becoming Hand Hygiene Heroes: implementation of an infection prevention and control campaign for patient and family hospital safety.

Author

Cheng B, Chan M, AbiFarrage D, Braschel M, Harrison P, and Srigley JA

Abstract

Background: The COVID-19 pandemic highlighted that hand hygiene is key in preventing healthcare-associated infections. Patients and families are understudied targets for infection prevention and control practices. Previous campaigns to change hand hygiene behavior have been effective, but often face systemic challenges with implementation., Methods: The "Hand Hygiene Heroes" educational campaign was developed to improve patient and family hand hygiene at two tertiary care pediatric and obstetrics hospitals. Its multiple phases included visual materials, tailored activities for nine hospital units, and long-term evaluation during a two-year period. Hand hygiene rates among patients/families and healthcare workers were measured at baseline and throughout the campaign via direct observation., Results: Overall, hand hygiene significantly increased for both patients/families (OR 1.82, p 0.041) and healthcare workers (OR 2.15, p <0.001) after campaign initiation. However, individual units had varying degrees of sustainment on follow-up evaluations., Discussion: Duration of intervention, activity simplicity, active participation, and resource availability may affect success of campaign initiatives. Positive prognostic factors included mixed leadership support from administration and front-line workers, pre-determined sustainability plans, and tailored activities by target audience., Conclusions: Implementation of hospital educational campaigns can be resource-intensive but can positively impact patient and family hand hygiene., (Copyright © 2024. Published by Elsevier Inc.)

Published
2024
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49. What Psychiatrists Should Know About Prescribed Safer Opioid Supply.

Author

Bahji A, Danilewitz M, Sachdev A, Mathew N, Lamba W, Rafizadeh R, Chopra N, Dhaliwal A, George TP, Crockford D, Primeau V, Tibbo P, Buckley L, and Tanguay R

Abstract

In this invited commentary, we provide an overview of safer opioid supply (SOS) initiatives, specifically aiming to examine the evidence base for SOS programs and the ensuing implications for clinical practice, particularly in the context of psychiatric care., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
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50. Self-reported Health Service Utilization and Barriers to Care Among US Adults with a History of Post COVID-19 Condition.

Author

Naik H, Perlis RH, Tran KC, and Staples JA

Abstract

Background: Millions of US adults continue to experience symptoms of post COVID-19 condition (PCC). More data on health service utilization patterns and barriers to care in this population are needed to understand how to care for people with PCC., Objective: To evaluate health service utilization and barriers to medical care among individuals with a history of PCC compared with other US adults., Design: Data were analyzed from the 2022 National Health Interview Survey (NHIS), a nationally representative, cross-sectional survey of the US population., Participants: US adults., Main Measures: Health service utilization and the presence of financial and nonfinancial barriers to care in the preceding 12 months., Key Results: There were 24,905 individuals included in the analysis, representing approximately 230 million US adults. The weighted prevalence of those with a history of PCC was 6.9% (95%CI, 6.5-7.3). Compared to other US adults, participants with a history of PCC were more likely to have had an urgent care visit (adjusted odds ratio (aOR) 1.52 [95%CI, 1.34-1.72]), emergency room visit (aOR 1.94 [95%CI 1.71-2.21]), hospitalization (aOR 1.48 [95%CI, 1.24-1.77]), rehabilitation services (aOR 1.35 [95%CI, 1.14-1.60]), home care (aOR 1.55 [95%CI, 1.66-2.26]), mental health counseling (aOR 1.39 [95%CI, 1.17-1.65]), and complementary and integrative medicine services (aOR 1.29 [95%CI, 1.13-1.49]). Furthermore, respondents with a history of PCC were more likely to report at least one financial barrier to care (aOR 1.71 [95%CI, 1.48-1.97]) and at least one nonfinancial barrier (aOR 1.77 [95%CI, 1.56-2.00]). A greater proportion of participants with a history of PCC reported a financial barrier and nonfinancial barrier than adults with most other chronic conditions captured by NHIS., Conclusions: Individuals with a history of PCC were more likely to use a variety of health services and report barriers to medical care. Health systems should consider developing accessible, multidisciplinary care pathways for this population., (© 2024. The Author(s), under exclusive licence to Society of General Internal Medicine.)

Published
2024
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