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Your search keyword '"Protopapa, Francesca"' showing total 11 results
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11 results on '"Protopapa, Francesca"'

1. The protease activated receptor 2 - CCAAT/enhancer-binding protein beta - SerpinB3 axis inhibition as a novel strategy for the treatment of non-alcoholic steatohepatitis

Author

Villano, Gianmarco, Novo, Erica, Turato, Cristian, Quarta, Santina, Ruvoletto, Mariagrazia, Biasiolo, Alessandra, Protopapa, Francesca, Chinellato, Monica, Martini, Andrea, Trevellin, Elisabetta, Granzotto, Marnie, Cannito, Stefania, Cendron, Laura, De Siervi, Silvia, Guido, Maria, Parola, Maurizio, Vettor, Roberto, and Pontisso, Patrizia

Published
2024
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3. Histidine-rich glycoprotein in metabolic dysfunction-associated steatohepatitis-related disease progression and liver carcinogenesis.

Author

Foglia, Beatrice, Sutti, Salvatore, Cannito, Stefania, Rosso, Chiara, Maggiora, Marina, Casalino, Alice, Bocca, Claudia, Novo, Erica, Protopapa, Francesca, Ramavath, Naresh Naik, Provera, Alessia, Gambella, Alessandro, Bugianesi, Elisabetta, Tacke, Frank, Albano, Emanuele, and Parola, Maurizio

Subjects
DISEASE progression, NON-alcoholic fatty liver disease, LIVER diseases, KNOCKOUT mice, CARCINOGENESIS, HUMAN carcinogenesis
Abstract

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously non-alcoholic fatty liver disease (NAFLD), is a leading cause of chronic liver disease worldwide. In 20%-30% of MASLD patients, the disease progresses to metabolic dysfunction-associated steatohepatitis (MASH, previously NASH) which can lead to fibrosis/cirrhosis, liver failure as well as hepatocellular carcinoma (HCC). Here we investigated the role of histidine-rich glycoprotein (HRG), a plasma protein produced by hepatocytes, in MASLD/MASH progression and HCC development. Methods: The role of HRG was investigated by morphological, cellular, and molecular biology approaches in (a) HRG knock-out mice (HRG-/- mice) fed on a CDAA dietary protocol or a MASH related diethyl-nitrosamine/CDAA protocol of hepatocarcinogenesis, (b) THP1 monocytic cells treated with purified HRG, and (c) well-characterized cohorts of MASLD patients with or without HCC. Results: In non-neoplastic settings, murine and clinical data indicate that HRG increases significantly in parallel with disease progression. In particular, in MASLD/MASH patients, higher levels of HRG plasma levels were detected in subjects with extensive fibrosis/cirrhosis. When submitted to the procarcinogenic protocol, HRG-/- mice showed a significant decrease in the volume and number of HCC nodules in relation to decreased infiltration of macrophages producing pro-inflammatory mediators, including IL-1b, IL-6, IL-12, IL-10, and VEGF as well as impaired angiogenesis. The histopathological analysis (H-score) of MASH-related HCC indicate that the higher HRG positivity in peritumoral tissue significantly correlates with a lower overall patient survival and an increased recurrence. Moreover, a significant increase in HRG plasma levels was detected in cirrhotic (F4) patients and in patients carrying HCC vs. F0/F1 patients. Conclusion: Murine and clinical data indicate that HRG plays a significant role in MASLD/MASH progression to HCC by supporting a specific population of tumorassociated macrophages with pro-inflammatory response and pro-angiogenetic capabilities which critically support cancer cell survival. Furthermore, our data suggest HRG as a possible prognostic predictor in HCC patients with MASLD/MASH-related HCCs. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Inhibition of CCAT/enhancer-binding protein beta-serpinB3 axis by 1-piperidin propionic acid: a new targeted therapy for non-alcoholic steatohepatitis

Author

Protopapa, Francesca, primary, Villano, Gianmarco, additional, Novo, Erica, additional, Turato, Cristian, additional, Quarta, Santina, additional, Ruvoletto, Mariagrazia, additional, Biasiolo, Alessandra, additional, Chinellato, Monica, additional, Martini, Andrea, additional, Trevellin, Elisabetta, additional, Granzotto, Marnie, additional, Cannito, Stefania, additional, Cendron, Laura, additional, Guido, Maria, additional, Parola, Maurizio, additional, Vettor, Roberto, additional, and Pontisso, Patrizia, additional

Published
2023
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5. SerpinB3 Upregulates Low-Density Lipoprotein Receptor-Related Protein (LRP) Family Members, Leading to Wnt Signaling Activation and Increased Cell Survival and Invasiveness

Author

Quarta, Santina, primary, Cappon, Andrea, additional, Turato, Cristian, additional, Ruvoletto, Mariagrazia, additional, Cannito, Stefania, additional, Villano, Gianmarco, additional, Biasiolo, Alessandra, additional, Maggi, Maristella, additional, Protopapa, Francesca, additional, Bertazza, Loris, additional, Fasolato, Silvano, additional, Parola, Maurizio, additional, and Pontisso, Patrizia, additional

Published
2023
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6. The CCAAT/Enhancer-Binding Protein Beta - SerpinB3 Axis Inhibition as a Novel Strategy for Non-Alcoholic Steatohepatitis Treatment

Author

Villano, Gianmarco, primary, Novo, Erica, additional, Turato, Cristian, additional, Quarta, Santina, additional, Ruvoletto, Mariagrazia, additional, Biasiolo, Alessandra, additional, Protopapa, Francesca, additional, Chinellato, Monica, additional, Martini, Andrea, additional, Trevellin, Elisabetta, additional, Granzotto, Marnie, additional, Cannito, Stefania, additional, Cendron, Laura, additional, De Siervi, Silvia, additional, Guido, Maria, additional, Parola, Maurizio, additional, Vettor, Robertoi, additional, and Pontisso, Patrizia, additional

Published
2023
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7. SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease

Author

Novo, Erica, primary, Cappon, Andrea, additional, Villano, Gianmarco, additional, Quarta, Santina, additional, Cannito, Stefania, additional, Bocca, Claudia, additional, Turato, Cristian, additional, Guido, Maria, additional, Maggiora, Marina, additional, Protopapa, Francesca, additional, Sutti, Salvatore, additional, Provera, Alessia, additional, Ruvoletto, Mariagrazia, additional, Biasiolo, Alessandra, additional, Foglia, Beatrice, additional, Albano, Emanuele, additional, Pontisso, Patrizia, additional, and Parola, Maurizio, additional

Published
2022
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10. WED-449 - Inhibition of CCAT/enhancer-binding protein beta-serpinB3 axis by 1-piperidin propionic acid: a new targeted therapy for non-alcoholic steatohepatitis

Author

Protopapa, Francesca, Villano, Gianmarco, Novo, Erica, Turato, Cristian, Quarta, Santina, Ruvoletto, Mariagrazia, Biasiolo, Alessandra, Chinellato, Monica, Martini, Andrea, Trevellin, Elisabetta, Granzotto, Marnie, Cannito, Stefania, Cendron, Laura, Guido, Maria, Parola, Maurizio, Vettor, Roberto, and Pontisso, Patrizia

Published
2023
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