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1. Tissue-specific variations of piperine in ten populations of Piper longum L.: bioactivities and toxicological profile

Author

Protha Biswas, Devendra Kumar Pandey, Mahipal S. Shekhawat, Abhijit Dey, and Tabarak Malik

Subjects
Medicine, Science
Abstract

Abstract P. longum L., one of the most significant species of the genus Piperaceae, is most frequently employed in Indian-Ayurvedic and other traditional medicinal-systems for treating a variety of illnesses. The alkaloid piperine, is the key phytoconstituent of the plant, primarily responsible for its’ pharmacological-impacts. The aim of the study is to analyse the intra-specific variation in piperine content among different chemotypes (PL1 to PL 30) and identify high piperine yielding chemotype (elite-chemotype) collected from 10 different geographical regions of West Bengal by validated HPTLC chromatography method. The study also focused on the pharmacological-screening to better understand the antioxidant activity of the methanol extracts of P. longum by DPPH and ABTS radical-scavenging activity and genotoxic activity by Allium cepa root tip assay. It was found that the P. longum fruit chemotypes contain high amount piperine (highest 16.362 mg/g in chemotype PL9) than the stem and leaf chemotypes. Both DPPH and ABTS antioxidant assays revealed that P. longum showed moderate radical-scavenging activity and the highest activity was found in PL9 (fruit) chemotype with IC50 values of 124.2 $$\pm 0.97$$ ± 0.97 and 104 $$\pm 0.78$$ ± 0.78 µg/ml respectively. The A. cepa root tip assay showed no such significant genotoxic-effect and change in mitotic-index. The quick, reproducible, and validated HPTLC approach offers a useful tool for determining quantitative variations of piperine among P. longum chemotypes from different geographical-regions and also according to the different tissues and choose elite genotypes with high piperine production for continued propagation and commercialization for the pharmaceutical sector. Additionally, the plant's in-vitro antioxidant property and lack of genotoxicity directly supports its’ widespread and long history of use as a medicinal and culinary plant.

Published
2024
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2. Corrigendum: Traditional uses, phytochemistry, pharmacology and toxicology of garlic (Allium sativum), a storehouse of diverse phytochemicals: a review of research from the last decade focusing on health and nutritional implications

Author

Champa Keeya Tudu, Tusheema Dutta, Mimosa Ghorai, Protha Biswas, Dipu Samanta, Patrik Oleksak, Niraj Kumar Jha, Manoj Kumar, Radha, Jarosław Proćków, José M. Pérez de laLastra, and Abhijit Dey

Subjects
Allium sativum, traditional uses, ethnobotany, phytochemistry, pharmacology, toxicology, Nutrition. Foods and food supply, TX341-641
Published
2024
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3. RETRACTED: Corrigendum: Cytokinin and abiotic stress tolerance ‐What has been accomplished and the way forward?

Author

Sayanti Mandal, Mimosa Ghorai, Uttpal Anand, Dipu Samanta, Nishi Kant, Tulika Mishra, Md. Habibur Rahman, Niraj Kumar Jha, Saurabh Kumar Jha, Milan Kumar Lal, Rahul Kumar Tiwari, Manoj Kumar, Radha, Dorairaj Arvind Prasanth, Abhijit Bhagwan Mane, Abilash Valsala Gopalakrishnan, Protha Biswas, Jarosław Proćków, and Abhijit Dey

Subjects
Cytokinin (CK), CK metabolic genes, CK signaling genes, abiotic stress, crop resilience, genome editing, Genetics, QH426-470
Published
2024
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4. Traditional uses, phytochemistry, pharmacology and toxicology of garlic (Allium sativum), a storehouse of diverse phytochemicals: A review of research from the last decade focusing on health and nutritional implications

Author

Champa Keeya Tudu, Tusheema Dutta, Mimosa Ghorai, Protha Biswas, Dipu Samanta, Patrik Oleksak, Niraj Kumar Jha, Manoj Kumar, Radha, Jarosław Proćków, José M. Pérez de la Lastra, and Abhijit Dey

Subjects
allium sativum, traditional uses, ethnobotany, phytochemistry, pharmacology, toxicology, Nutrition. Foods and food supply, TX341-641
Abstract

Allium sativum L. (Garlic) is a fragrant herb and tuber-derived spice that is one of the most sought-after botanicals, used as a culinary and ethnomedicine for a variety of diseases around the world. An array of pharmacological attributes such as antioxidant, hypoglycemic, anti-inflammatory, antihyperlipidemic, anticancer, antimicrobial, and hepatoprotective activities of this species have been established by previous studies. A. sativum houses many sulfur-containing phytochemical compounds such as allicin, diallyl disulfide (DADS), vinyldithiins, ajoenes (E-ajoene, Z-ajoene), diallyl trisulfide (DATS), micronutrient selenium (Se) etc. Organosulfur compounds are correlated with modulations in its antioxidant properties. The garlic compounds have also been recorded as promising immune-boosters or act as potent immunostimulants. A. sativum helps to treat cardiovascular ailments, neoplastic growth, rheumatism, diabetes, intestinal worms, flatulence, colic, dysentery, liver diseases, facial paralysis, tuberculosis, bronchitis, high blood pressure, and several other diseases. The present review aims to comprehensively enumerate the ethnobotanical and pharmacological aspects of A. sativum with notes on its phytochemistry, ethnopharmacology, toxicological aspects, and clinical studies from the retrieved literature from the last decade with notes on recent breakthroughs and bottlenecks. Future directions related to garlic research is also discussed.

Published
2022
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5. RETRACTED: Cytokinin and abiotic stress tolerance -What has been accomplished and the way forward?

Author

Sayanti Mandal, Mimosa Ghorai, Uttpal Anand, Dipu Samanta, Nishi Kant, Tulika Mishra, Md. Habibur Rahman, Niraj Kumar Jha, Saurabh Kumar Jha, Milan Kumar Lal, Rahul Kumar Tiwari, Manoj Kumar, Radha, Dorairaj Arvind Prasanth, Abhijit Bhagwan Mane, Abilash Valsala Gopalakrishnan, Protha Biswas, Jarosław Proćków, and Abhijit Dey

Subjects
cytokinin (CK), CK metabolic genes, CK signaling genes, abiotic stress, crop resilience, genome editing, Genetics, QH426-470
Abstract

More than a half-century has passed since it was discovered that phytohormone cytokinin (CK) is essential to drive cytokinesis and proliferation in plant tissue culture. Thereafter, cytokinin has emerged as the primary regulator of the plant cell cycle and numerous developmental processes. Lately, a growing body of evidence suggests that cytokinin has a role in mitigating both abiotic and biotic stress. Cytokinin is essential to defend plants against excessive light exposure and a unique kind of abiotic stress generated by an altered photoperiod. Secondly, cytokinin also exhibits multi-stress resilience under changing environments. Furthermore, cytokinin homeostasis is also affected by several forms of stress. Therefore, the diverse roles of cytokinin in reaction to stress, as well as its interactions with other hormones, are discussed in detail. When it comes to agriculture, understanding the functioning processes of cytokinins under changing environmental conditions can assist in utilizing the phytohormone, to increase productivity. Through this review, we briefly describe the biological role of cytokinin in enhancing the performance of plants growth under abiotic challenges as well as the probable mechanisms underpinning cytokinin-induced stress tolerance. In addition, the article lays forth a strategy for using biotechnological tools to modify genes in the cytokinin pathway to engineer abiotic stress tolerance in plants. The information presented here will assist in better understanding the function of cytokinin in plants and their effective investigation in the cropping system.

Published
2022
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6. Plant nutrient dynamics: a growing appreciation for the roles of micronutrients

Author

Sayanti Mandal, Santosh Kumar Gupta, Mimosa Ghorai, Manoj Tukaram Patil, Protha Biswas, Manoj Kumar, null Radha, Abilash Valsala Gopalakrishnan, Vikas Moreshwar Mohture, Md. Habibur Rahman, Dorairaj Arvind Prasanth, Abhijit Bhagwan Mane, Niraj Kumar Jha, Saurabh Kumar Jha, Milan Kumar Lal, Rahul Kumar Tiwari, and Abhijit Dey

Subjects
Physiology, Plant Science, Agronomy and Crop Science
Published
2023
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11. Aloe vera (L.) Burm.f

Author

Surjit Sen, Shuvadip Mondal, Arghya Naskar, Protha Biswas, Tuyelee Das, Rupa Sanyal, Abhijit Dey, and Manjula Rai

Published
2023
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14. List of contributors

Author

Cristóbal N. Aguilar, Nahid Akhtar, Abdel Rahman Al-Tawaha, Elham M. Ali, Omar Aweiss Ali, Angela Alves dos Santos, Sérgio Luiz Alves Júnior, Juliana Heloisa Pinê Américo-Pinheiro, S.A. Aransiola, Marlón José Bastidas Barranco, Sudhanshu S. Behera, Sayan Bhattacharya, Protha Biswas, Manswama Boro, Germán Buitrón, Ercan Bursal, Alejandra Cabello-Galindo, Aline Frumi Camargo, Isaac Chairez, Indu Chauhan, Atef Chibani, Muskaan Chopra, Chirag Chopra, Mónica L. Chávez-González, Pranjal P. Das, Urmimala Das, Tuyelee Das, Aissa Dehane, Shibam Dey, Abhijit Dey, Satarupa Dey, Simons Dhara, Prajwal P. Dongare, Prangan Duarah, Ghadir Aly El-Chaghaby, Mostafa M. El-Sheekh, Mostafa Elshobary, Mustafa A. Fawzy, Mimosa Ghorai, Sougata Ghosh, Arabinda Ghosh, Liliana Giraldo, Mohamed Gomaa, Cristina González-Fernández, Ranjit Gurav, Dibyajyoti Haldar, Bishnupriya Hansdah, Ikram ul Haq, Laura Helena dos Santos, Sangchul Hwang, Rahul Jadhav, Jyoti Jadhav, Priyanka Kamilya, Kondragunta Prasanna Kumar, Vineet Kumar, Subrat Kumar, S.S. Leh-Togi Zobeashia, Samanta Machado-Cepeda, Naga Raju Maddela, Sujata Mandal, José Manuel Martínez Gil, Ishanee Mazumder, Slimane Merouani, William Michelon, Juan Carlos Moreno-Piraján, Hamid Mukhtar, Sikandar I. Mulla, Ali Nawaz, Leila Nemdili, Potshangbam Nongdam, Sandeep Kumar Panda, Hiren K. Patel, Nidhi P. Patel, Sagarjyoti Pathak, Ritesh Pattnaik, Hitesh S. Pawar, V.T. Perarasu, Mihir Kumar Purkait, Guillermo Quijano, null Quratulain, Pabbati Ranjit, Sayed Rashad, Palvi Ravinder, Ramesh C. Ray, Kondakindi Venkateswar Reddy, Pawan Rekha, Neelancherry Remya, Ricardo Vivas Reyes, Rosa M. Rodríguez-Jasso, Gilver Rosero-Chasoy, Chandrashish Roy, Héctor A. Ruiz, Niladri S. Samanta, R. Saravanathamizhan, Bishwarup Sarkar, Nalam Renuka Satya Sree, Rohit Saxena, Thamarys Scapini, Maulin P. Shah, Falak Shaheen, Emad A. Shalaby, Sanaa M.M. Shanab, Vivek Sharma, Indu Sharma, Farooq Sher, Soumya Singh, Shalini Singh, Reena Singh, Lovjeet Singh, Ankush D. Sontakke, Tanvi Taneja, Sirikanjana Thongmee, Prashnasa Tiwari, Helen Treichel, Navanath Valekar, Anil Kumar Verma, K. Vetriselvan, Aline Viancelli, M.O. Victor-Ekwebelem, Atif Khurshid Wani, and Vasudeo Zambare

Published
2023
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17. Piper longum L.: A comprehensive review on traditional uses, phytochemistry, pharmacology, and health-promoting activities

Author

Protha Biswas, Mimosa Ghorai, Tulika Mishra, Abilash Valsala Gopalakrishnan, Debleena Roy, Abhijit Bhagwan Mane, Avinash Mundhra, Neela Das, Vikas Moreshwar Mohture, Manoj Tukaram Patil, Md. Habibur Rahman, Niraj Kumar Jha, Gaber El‐Saber Batiha, Suchismita Chatterjee Saha, Mahipal S Shekhawat, null Radha, Manoj Kumar, Devendra Kumar Pandey, and Abhijit Dey

Subjects
Pharmacology
Abstract

Piper longum (family Piperaceae), commonly known as "long-pepper" or "Pippali" grows as a perennial shrub or as an herbaceous vine. It is native to the Indo-Malaya region and widely distributed in the tropical and subtropical world including the Indian subcontinent, Sri Lanka, Middle-East, and America. The fruits are mostly used as culinary spice and preservatives and are also a potent remedy in various traditional medicinal systems against bronchitis, cough, cold, snakebite, and scorpion-sting and are also used as a contraceptive. Various bioactive-phytochemicals including alkaloids, flavonoids, esters, and steroids were identified from the plant extracts and essential oils from the roots and fruits were reported as antimicrobial, antiparasitic, anthelminthic, mosquito-larvicidal, antiinflammatory, analgesic, antioxidant, anticancer, neuro-pharmacological, antihyperglycaemic, hepato-protective, antihyperlipidaemic, antiangiogenic, immunomodulatory, antiarthritic, antiulcer, antiasthmatic, cardioprotective, and anti-snake-venom agents. Many of its pharmacological properties were attributed to its antioxidative and antiinflammatory effects and its ability to modulate a number of signalling pathways and enzymes. This review comprehensively encompasses information on habit, distribution, ethnobotany, phytochemistry, and pharmacology of P. longum in relation to its medicinal importance and health benefits to validate the traditional claims supported by specific scientific experiments. In addition, it also discusses the safety and toxicity studies, application of green synthesis and nanotechnology as well as clinical trials performed with the plant also elucidating research gaps and future perspectives of its multifaceted uses.

Published
2022

18. Cytokinin and abiotic stress tolerance -What has been accomplished and the way forward?

Author

Sayanti Mandal, Mimosa Ghorai, Uttpal Anand, Dipu Samanta, Nishi Kant, Tulika Mishra, Md. Habibur Rahman, Niraj Kumar Jha, Saurabh Kumar Jha, Milan Kumar Lal, Rahul Kumar Tiwari, Manoj Kumar, null Radha, Dorairaj Arvind Prasanth, Abhijit Bhagwan Mane, Abilash Valsala Gopalakrishnan, Protha Biswas, Jarosław Proćków, and Abhijit Dey

Subjects
Genetics, Molecular Medicine, Genetics (clinical)
Abstract

More than a half-century has passed since it was discovered that phytohormone cytokinin (CK) is essential to drive cytokinesis and proliferation in plant tissue culture. Thereafter, cytokinin has emerged as the primary regulator of the plant cell cycle and numerous developmental processes. Lately, a growing body of evidence suggests that cytokinin has a role in mitigating both abiotic and biotic stress. Cytokinin is essential to defend plants against excessive light exposure and a unique kind of abiotic stress generated by an altered photoperiod. Secondly, cytokinin also exhibits multi-stress resilience under changing environments. Furthermore, cytokinin homeostasis is also affected by several forms of stress. Therefore, the diverse roles of cytokinin in reaction to stress, as well as its interactions with other hormones, are discussed in detail. When it comes to agriculture, understanding the functioning processes of cytokinins under changing environmental conditions can assist in utilizing the phytohormone, to increase productivity. Through this review, we briefly describe the biological role of cytokinin in enhancing the performance of plants growth under abiotic challenges as well as the probable mechanisms underpinning cytokinin-induced stress tolerance. In addition, the article lays forth a strategy for using biotechnological tools to modify genes in the cytokinin pathway to engineer abiotic stress tolerance in plants. The information presented here will assist in better understanding the function of cytokinin in plants and their effective investigation in the cropping system.

Published
2022

21. Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Author

Protha Biswas, Uttpal Anand, Suchismita Chatterjee Saha, Nishi Kant, Tulika Mishra, Harison Masih, Ananya Bar, Devendra Kumar Pandey, Niraj Kumar Jha, Madhumita Majumder, Neela Das, Vijaykumar Shivaji Gadekar, Mahipal S. Shekhawat, Manoj Kumar, null Radha, Jarosław Proćków, José M. Pérez de la Lastra, Abhijit Dey, European Commission, Agencia Canaria de Investigación, Innovación y Sociedad de la Información, Gobierno de Canarias, and Caja Canarias

Subjects
Betelvine (Piper betle L.), Plant Extracts, Cell Biology, hydroxychavicol, phytochemicals, Antioxidants, Piper betle, Plant Leaves, ethnobotany, Ethnopharmacology, Molecular Medicine, nanoparticles, pharmacology
Abstract

Piper betle L. (synonym: Piper betel Blanco), or betel vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as the green gold. The plant can be found all over the world and is cultivatedprimarily in South East Asian countries for its beautiful glossy heart-shaped leaves, which are chewed or consumed as betelquidand widely used in Chinese and Indian folk medicine, as carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also used for religious purposes. Hydroxychavicol is the most important bioactive compound among the wide range of phytoconstituents found in essential oil and extracts. The pharmacological attributes of P. betle are antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal and many more. Immense attention has been paid to nanoformulations and their applications. The application of P. betle did not show cytotoxicity in preclinical experiments, suggesting that it could serve as a promising therapeutic candidate for different diseases. The present review comprehensively summarizes the botanical description, geographical distribution, economic value and cultivation, ethnobotanical uses, preclinical pharmacological properties with insights of toxicological, clinical efficacy, and safety of P. betle. The findings suggest that P. betle represents an orally active and safe natural agent that exhibits great therapeutic potential for managing various human medical conditions. However, further research is needed to elucidate its underlying molecular mechanisms of action, clinical aspects, structure–activity relationships, bioavailability and synergistic interactions with other drugs., This research was funded by projects APOGEO (Cooperation Program INTERREG-MAC 2014–2020, with European Funds for Regional Development-FEDER, ‘Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) del Gobierno de Canarias’ (project ProID2020010134), and CajaCanarias (project 2019SP43).

Published
2022

25. List of contributors

Author

Ladan Ajdanian, Hanife Akça, Muhittin Onur Akça, Behnam Asgari Lajayer, Waleed Asghar, Tess Astatkie, Mehdi Babaei, Ayush Bahuguna, Khosro Balilashaki, Reshu Bhardwaj, Abhishek Bharti, Mishra Bhawana, Zahra Biglari Quchan Atigh, Protha Biswas, Oluwole Oluwatoyin Bolanle, Charline Bonatto, Bandana Bose, Aline Frumi Camargo, Subhash Chand, Jyoti Chauhan, Dipanti Chourasiya, Vallabhaneni Tilak Chowdary, Zahra Dehghanian, Abhijit Dey, Jagana Divya, Tusheema Dutta, Padmanabh Dwivedi, S.A. Dwivedi, Raji Fatima, Manal Fawzy, Cristiane Funghetto Fuzinatto, Rahul Gajghate, Fernando Carlos Gómez-Merino, Libia Fernanda Gómez-Trejo, T. Hemadri, Akash Hidangmayum, Mohamed Hosny, null Indu, C.S. Jayaram, Ryota Kataoka, Harpreet Kaur, Manmeet Kaur, Natalia Klanovicz, Basant Kumar, Vivek Kumar, Hemant Singh Maheshwari, Alaa El Din Mahmoud, B.L. Manisha, Udit Nandan Mishra, Monireh Mones Sardrodi, Chandra Muktesh, Lelika Nameirakpam, Samapika Nandy, Pooja Nikhanj, Abodurin Josephine Olabisi, Ibironke Olaide, Letícia Paliga, Astha Pandey, Devendra Kumar Pandey, Anil Prakash, Ashish Rai, M. Ramaiah, N. Ramana, SK Roshan Baba, Rubén Ruvalcaba-Ramírez, Sanjib Kumar Sahoo, Seema Sangwan, Anjney Sharma, Mahaveer Prasad Sharma, Pankaj Sharma, Sachin Sharma, Singh Shiwani, Meena Sindhu, Ankita Singh, Bansh Narayan Singh, Joginder Singh, Mohini Prabha Singh, Pratiksha Singh, Rajesh Kumar Singh, Rajesh Kumar Singhal, Harpreet Singh Sodhi, Fábio Spitza Stefanski, Ommolbanin Jafari Tarf, Pushpendra Tiwari, Ajay Tomer, Helen Treichel, Libia Iris Trejo-Téllez, Oğuz Can Turgay, P. Kishore Varma, Andressa Warken, Leela Wati, and Bharti Yadav

Published
2022
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26. Unraveling the promise and limitations of CRISPR/Cas system in natural product research: Approaches and challenges

Author

Protha Biswas, Uttpal Anand, Mimosa Ghorai, Devendra Kumar Pandey, Niraj Kumar Jha, Tapan Behl, Manoj Kumar, Radha Chauhan, Mahipal S Shekhawat, and Abhijit Dey

Subjects
Gene Editing, Biological Products, Molecular Medicine, Humans, General Medicine, CRISPR-Cas Systems, Plants, Genetic Engineering, Applied Microbiology and Biotechnology
Abstract

An incredible array of natural products is produced by plants that serve several ecological functions, including protecting them from herbivores and microbes, attracting pollinators, and dispersing seeds. In addition to their obvious medical applications, natural products serve as flavoring agents, fragrances, and many other uses by humans. With the increasing demand for natural products and the development of various gene engineering systems, researchers are trying to modify the plant genome to increase the biosynthetic pathway of the compound of interest or blocking the pathway of unwanted compound synthesis. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has had widespread success in genome editing due to the system's high efficiency, ease of use, and accuracy which revolutionized the genome editing system in living organisms. This study highlights the method of the CRISPR/Cas system, its application in different organisms including microbes, algae, fungi, and also higher plants in natural product research, and its shortcomings and future prospects.

Published
2021

27. List of contributors

Author

Nahid Akhtar, M. Amin-ul Mannan, R.M. Banik, Ömür Baysal, Surojit Bera, Protha Biswas, Evangeline Christina, Tuyelee Das, Banhishikha Datta, Priyanka Devi, Abhijit Dey, Shipa Rani Dey, Padmanabh Dwivedi, Jing Han, Chelliah Jayabaskaran, Subban Kamalraj, Prabhjot Kaur, Prasann Kumar, Vijay Kumar, Upasana Mangrolia, Ruchira Mitra, Shreya Sikdar Mitra, Anuradha Mukherjee, Samapika Nandy, Santhanam Narmadha, Potshanghbam Nongdam, W. Jabez Osborne, Devendra Kumar Pandey, Janmejay Pandey, Ramalingam Parthasarathy, T. Ramachandira Prabu, T.C. Prathna, Swarnkumar Reddy, Lalit Saini, Khushbu Sharma, Ragıp Soner Silme, Bishal Singh, Monika Singh, Ranjit Singh, Astha Sinha, Saravanan Sivarajan, Navnita Srivastava, D. Sruthi, Kothandapani Sundar, Champa Keya Tudu, Jeevanandam Vaishnavi, Pratibha Vyas, Mrunal S. Wagh, Atif Khurshid Wani, Hua Xiang, and H.C. Yashavantha Rao

Published
2021
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