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4 results on '"Proteina acídica fibrilar glial"'

1. Improving immunoassays to achieve earlier diagnostics

Author

Vasconcelos, Mafalda Alexandra Longarito de and Martins, Ivo C.

Subjects
Bioquímica, Nanomateriais, Interações proteína-ligando, Imuno-diagnósticos, Proteína acídica fibrilar glial, Ciências Médicas [Domínio/Área Científica]
Abstract

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2018 Submitted by Sofia Amador (sofiamador@fm.ul.pt) on 2020-03-11T14:13:15Z No. of bitstreams: 1 MafaldaLVasconcelos.pdf: 2793672 bytes, checksum: 13c95f421f3352e763de957106c40e6c (MD5) Made available in DSpace on 2020-03-11T16:20:53Z (GMT). No. of bitstreams: 1 MafaldaLVasconcelos.pdf: 2793672 bytes, checksum: 13c95f421f3352e763de957106c40e6c (MD5) Previous issue date: 2018

Published
2018

2. Myelin changes in Alexander disease.

Author

Gómez-Pinedo U, Duran-Moreno M, Sirerol-Piquer S, and Matias-Guiu J

Subjects
Alexander Disease pathology, Animals, Glial Fibrillary Acidic Protein metabolism, Humans, Myelin Sheath pathology, Alexander Disease metabolism, Myelin Sheath metabolism
Abstract

Introduction: Alexander disease (AxD) is a type of leukodystrophy. Its pathological basis, along with myelin loss, is the appearance of Rosenthal bodies, which are cytoplasmic inclusions in astrocytes. Mutations in the gene coding for GFAP have been identified as a genetic basis for AxD. However, the mechanism by which these variants produce the disease is not understood., Development: The most widespread hypothesis is that AxD develops when a gain of function mutation causes an increase in GFAP. However, this mechanism does not explain myelin loss, given that experimental models in which GFAP expression is normal or mutated do not exhibit myelin disorders. This review analyses other possibilities that may explain this alteration, such as epigenetic or inflammatory alterations, presence of NG2 (+) - GFAP (+) cells, or post-translational modifications in GFAP that are unrelated to increased expression., Conclusions: The different hypotheses analysed here may explain the myelin alteration affecting these patients, and multiple mechanisms may coexist. These theories raise the possibility of designing therapies based on these mechanisms., (Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2018
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3. Modulation of glial fibrillary acidic protein immunoreactivity during Sparus aurata L. development. A preliminary report

Author

Busquets, Xavier, Morales-Nin, Beatriz, Ventayol, Pedro, Busquets, Xavier, Morales-Nin, Beatriz, and Ventayol, Pedro

Abstract

[EN] A band of approximately 50-5 1 kDa, corresponding to glial fibrillary acidic protein (GFAP), was detected by immunoblot techniques in the brain tissue of Sparus aurata L. The levels of GFAP immunoreactivity were determined at three different stages of development: 6 month old, 18 month old and adults reared in an aquaculture facility for 3-4 years. Our results indicated a decrease of GFAP levels during S. aurata development from six month old to adult individuals. An explanation for this observation is suggested., [ES] Una banda de aproximadamente 50-51 kDa correspondiente a la proteína acídica glial fibrilar (GFAP) fue detectada mediante técnicas de inmunoblot en tejido cerebral de Sparus aurata L. desarrollado en piscifactoría. Se determinaron los niveles de GFAP en tres diferentes estados de desarrollo: especímenes de 6 y 18 meses de edad y adultos mantenidos en cautividad durante 3-4 años. Nuestros resultados indican una disminución de los niveles de GFAP durante el desarrollo de S. aurata de 6 meses a adulto. Se susiere una explicación para esta observación.

Published
1996

4. Modulación de la proteína acídica fibrilar glial durante el desarrollo de Sparus aurata L

Author

Busquets, X., Beatriz Morales-Nin, and Ventayol, P.

Subjects
Sparus aurata, GFAP, Desarrollo de pez marino, Western blot, Marine fish development, Proteina acídica fibrilar glial, Glial fibrillary acidic protein, Immunoblot
Abstract

5 páginas, 2 figuras, 1 tabla., [EN] A band of approximately 50-5 1 kDa, corresponding to glial fibrillary acidic protein (GFAP), was detected by immunoblot techniques in the brain tissue of Sparus aurata L. The levels of GFAP immunoreactivity were determined at three different stages of development: 6 month old, 18 month old and adults reared in an aquaculture facility for 3-4 years. Our results indicated a decrease of GFAP levels during S. aurata development from six month old to adult individuals. An explanation for this observation is suggested., [ES] Una banda de aproximadamente 50-51 kDa correspondiente a la proteína acídica glial fibrilar (GFAP) fue detectada mediante técnicas de inmunoblot en tejido cerebral de Sparus aurata L. desarrollado en piscifactoría. Se determinaron los niveles de GFAP en tres diferentes estados de desarrollo: especímenes de 6 y 18 meses de edad y adultos mantenidos en cautividad durante 3-4 años. Nuestros resultados indican una disminución de los niveles de GFAP durante el desarrollo de S. aurata de 6 meses a adulto. Se susiere una explicación para esta observación.

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