8 results on '"Prostanoids -- Health aspects"'
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2. Data on Pharmacology Detailed by D.F. Woodward and Co-Authors (The Affinity, Intrinsic Activity and Selectivity of a Structurally Novel Ep2 Receptor Agonist At Human Prostanoid Receptors)
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Cell receptors -- Health aspects ,Glaucoma -- Genetic aspects -- Care and treatment ,Prostanoids -- Health aspects ,Obesity ,Anti-inflammatory agents ,Pharmacology ,Physical fitness ,Novels ,Editors ,Health - Abstract
2019 MAR 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Drugs and Therapies - Pharmacology have been published. [...]
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- 2019
3. Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue
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Norregaard, Rikke, Jensen, Boye L., Topcu, Sukru Oguzkan, Wang, Guixian, Schweer, Horst, Nielsen, Soren, and Frokiaer, Jorgen
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COX-2 inhibitors -- Dosage and administration ,Prostanoids -- Health aspects ,Prostanoids -- Research ,Ureters -- Obstructions ,Ureters -- Drug therapy ,Ureters -- Research ,Biological sciences - Abstract
Norregaard R, Jensen BL, Topcu SO, Wang G, Schweer H, Nielsen S, Frokiaer J. Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. Am J Physiol Regul Integr Comp Physiol 298: R1017-R1025, 2010. First published February 10, 2010; doi:10.11 152/ajpregu.00336.2009.--Inhibitors of cyclooxygenase (COX)-2 prevent suppression of aquaporin-2 and reduce polyuria in the acute phase after release of bilateral ureteral obstruction (BUO). We hypothesized that BUO leads to COX-2-mediated local accumulation of prostanoids in inner medulla (IM) tissue. To test this, rats were subjected to BUO and treated with selective COX-1 or COX-2 inhibitors. Tissue was examined at 2, 6, 12, and 24 h after BUO. COX-2 protein abundance increased in IM 12 and 24 h after onset of BUO but did not change in cortex. COX-I did not change at any time points in any region. A full profile of all five primary prostanoids was obtained by mass spectrometric determination of PG[E.sub.2], PG[F.sub.2[alpha]], 6-keto-PG[F.sub.1[alpha]], PG[D.sub.2], and thromboxane (Tx) [B.sub.2] concentrations in kidney cortex/outer medulla and IM fractions. IM concentration of PG[E.sub.2], 6-keto-PG[F.sub.1[alpha]], and PG[F.sub.2[alpha]] was increased at 6 h BUO, and PG[E.sub.2] and PG[F.sub.2[alpha]] increased further at 12 h BUO. Tx[B.sub.2] increased after 12 h BUO. 6-keto-PG[F.sub.1[alha]] remained significantly increased after 24 h BUO. The COX-2 inhibitor parecoxib lowered IM PG[E.sub.2]. Tx[B.sub.2], 6-keto-PG[F.sub.1[alpha]], and PG[F.sub.2[alpha]] below vehicle-treated BUO and sham rats at 6, 12 and, 24 h BUO. The COX-1 inhibitor SC-560 lowered PG[E.sub.2], PG[F.sub.2[alpha]], and PG[D.sub.2] in IM compared with untreated 12 h BUO, but levels remained significantly above sham. In cortex tissue, PG[E.sub.2] and 6-keto-PG[F1[alpha]] concentrations were elevated at 6 h only. In conclusion, COX-2 activity contributes to the transient increase in prostacyclin metabolite 6-keto-PG[F.sub.1[alpha]] and Tx[B.sub.2] concentration in the kidney IM, and COX-2 is the predominant isoform that is responsible for accumulation of PGE2 and PG[F.sub.2[alpha]] with minor, but significant, contributions from COX-1. PG[D.sub.2] synthesis is mediated exclusively by COX-1. In BUO, therapeutic interventions aimed at the COXprostanoid pathway should target primarily COX-2. bilateral ureteral obstruction; cyclooxygenase-2; mass spectrometric doi: 10.1152/Npregu.00336.2009.
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- 2010
4. Preterm labor and bacterial intraamniotic infection: Arachidonic acid liberation by phospholipase A.sub.2 of Fusobacterium nucleatum
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Mikamo, Hiroshige, Kawazoe, Kyoko, Sato, Yasumasa, Imai, Atsushi, and Tamaya, Teruhiko
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Prostanoids -- Health aspects ,Gram-negative bacteria -- Health aspects ,Phospholipases -- Health aspects ,Premature labor -- Health aspects ,Bacterial infections -- Health aspects ,Phospholipids -- Health aspects ,Cell research -- Health aspects ,Unsaturated fatty acids -- Health aspects ,Arachidonic acid -- Health aspects ,Prostaglandins -- Synthesis ,Prostaglandins -- Health aspects ,Health - Abstract
Byline: Hiroshige Mikamo, Kyoko Kawazoe, Yasumasa Sato, Atsushi Imai, Teruhiko Tamaya Keywords: Arachidonic acid; Fusobacterium nucleatum , phospholipase A.sub.2 , preterm labor Abstract: Objective: The studies presented in this report were undertaken to evaluate whether Fusobacterium nucleatum , a common anaerobic isolate in intrauterine infection, stimulates arachidonic acid metabolism, a rate-limiting step for prostaglandin synthesis, in the human uterine endometrium. Study Design: Effects of F nucleatum on arachidonic acid liberation from human uterine endometrial cells and of F nucleatum extract on lysophosphatidylcholine production in human uterine endometrial cells were investigated. Results: When human uterine endometrial cells labeled with tritiated arachidonic acid to an isotopically steady state were exposed to an extract of F nucleatum , arachidonic acid liberation was stimulated, accompanied by lysophospholipid formation. Similar stimulatory effects on phospholipid degradation were also observed in the experiment with bacterially conditioned media. Conclusions: These results suggest that F nucleatum stimulates endometrial phospholipid metabolism, related to activity of phospholipase A.sub.2 , which might induce the onset of labor associated with intraamniotic infection. (Am J Obstet Gynecol 1998;179:1579-82.) Author Affiliation: Department of Obstetrics and Gynecology, School of Medicine, Gifu University. Gifu, Japan Article History: Received 11 November 1997; Revised 29 May 1998; Accepted 29 May 1998 Article Note: (footnote) [star] Reprint requests: Hiroshige Mikamo, MD, PhD, Department of Obstetrics and Gynecology, School of Medicine, Gifu University, 40, Tsukasa-machi, Gifu-city, Gifu 500-8705, Japan., [star][star] 0002-9378/98 $5.00 + 0 6/1/92097
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- 1998
5. Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery
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Gu, Y.J., Devries, A.J., Boonstra, P.W., and Van Oeveren, W.
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Coronary artery bypass -- Health aspects ,Animal experimentation -- Health aspects ,Prostanoids -- Health aspects ,Cardiac patients -- Health aspects ,Company earnings/profit ,Health - Abstract
Byline: Y.J. Gu, A.J. deVries, P.W. Boonstra, W. van Oeveren Abstract: Leukocyte depletion during cardiopulmonary bypass has been demonstrated in animal experiments to improve pulmonary function. Conflicting results have been reported, however, with clinical depletion by arterial line filter of leukocytes at the beginning of cardiopulmonary bypass. In this study, we examined whether leukocyte depletion from the residual heart-lung machine blood at the end of cardiopulmonary bypass would improve lung function and reduce the postoperative inflammatory response. Thirty patients undergoing elective heart operations were randomly allocated to a leukocyte-depletion group or a control group. In the leukocyte-depletion group (n = 20), all residual blood (1.2 to 2.1 L) was filtered by leukocyte-removal filters and reinfused after cardiopulmonary bypass, whereas in the control group an identical amount of residual blood after cardiopulmonary bypass was reinfused without filtration (n = 10). Leukocyte depletion removed more than 97% of leukocytes from the retransfused blood (p < 0.01) and significantly reduced circulating leukocytes (p < 0.05) and granulocytes (p < 0.05) compared with the control group. Levels of the inflammatory mediator thromboxane B.sub.2 determined at the end of operation (p < 0.05) were significantly lower in the depletion group than in the control group, whereas no statistical differences in interleukin-6 levels were found between the two groups. After operation, pulmonary gas exchange function (arterial oxygen tension at a fraction of inspired oxygen of 0.4) was significantly higher in the leukocyte-depletion group 1 hour after arrival to the intensive care unit (p < 0.05) and after extubation (p < 0.05). There were no statistical differences between the two groups with respect to postoperative circulating platelet levels and blood loss, and no infections were observed during the whole period of hospitalization. These results suggest that leukocyte depletion of the residual heart-lung machine blood improves postoperative lung gas exchange function and is safe for patients who are expected to have a severe inflammatory response after heart operations. (J Thorac Cardiovasc Surg 1996;112:494-500) Article History: Received 19 September 1995; Revised 21 November 1995; Revised 14 December 1995; Accepted 21 December 1995 Article Note: (footnote) [star] From the Departments of Cardiothoracic Surgerya and Anesthesiology,b University Hospital, Groningen, The Netherlands., [star][star] Address for reprints: W. van Oeveren, PhD, Blood Interaction Research, Department of Cardiothoracic Surgery, University Hospital Groningen, 59 Oostersingel, 9713 EZ Groningen, The Netherlands., a 0022-5223/96 $5.00 + 0, aa 12/1/71449
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- 1996
6. The expression of signal transduction proteins and their relationship to clinical findings in patients with nonsmall cell lung cancer
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Jones, Dennie V., Jr., Sanati, Souzan, Haque, Abida, Freeman, Daniel, Kessel, Ivan, Zwischenberger, Joseph, and Xie, Jingwu
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Inositol -- Genetic aspects ,Inositol -- Health aspects ,Isoenzymes -- Genetic aspects ,Isoenzymes -- Health aspects ,Colon cancer -- Care and treatment ,Colon cancer -- Prognosis ,Colon cancer -- Development and progression ,Colon cancer -- Genetic aspects ,Colon cancer -- Health aspects ,Protein binding -- Genetic aspects ,Protein binding -- Health aspects ,Tyrosine -- Genetic aspects ,Tyrosine -- Health aspects ,Squamous cell carcinoma -- Care and treatment ,Squamous cell carcinoma -- Prognosis ,Squamous cell carcinoma -- Development and progression ,Squamous cell carcinoma -- Genetic aspects ,Squamous cell carcinoma -- Health aspects ,Gene mutations -- Genetic aspects ,Gene mutations -- Health aspects ,Vascular endothelial growth factor -- Genetic aspects ,Vascular endothelial growth factor -- Health aspects ,Prostanoids -- Genetic aspects ,Prostanoids -- Health aspects ,Lung cancer, Non-small cell -- Care and treatment ,Lung cancer, Non-small cell -- Prognosis ,Lung cancer, Non-small cell -- Development and progression ,Lung cancer, Non-small cell -- Genetic aspects ,Lung cancer, Non-small cell -- Health aspects ,Phosphotransferases -- Genetic aspects ,Phosphotransferases -- Health aspects ,Radiotherapy -- Genetic aspects ,Radiotherapy -- Health aspects ,Arachidonic acid -- Genetic aspects ,Arachidonic acid -- Health aspects ,Tumor necrosis factor -- Genetic aspects ,Tumor necrosis factor -- Health aspects ,Immunohistochemistry -- Genetic aspects ,Immunohistochemistry -- Health aspects ,Metastasis -- Care and treatment ,Metastasis -- Prognosis ,Metastasis -- Development and progression ,Metastasis -- Genetic aspects ,Metastasis -- Health aspects ,Antigens -- Genetic aspects ,Antigens -- Health aspects ,Lipids -- Genetic aspects ,Lipids -- Health aspects ,RNA -- Genetic aspects ,RNA -- Health aspects ,Threonine -- Genetic aspects ,Anti-inflammatory drugs -- Genetic aspects ,Anti-inflammatory drugs -- Health aspects ,Chemotherapy -- Genetic aspects ,Chemotherapy -- Health aspects ,Monoclonal antibodies -- Genetic aspects ,Monoclonal antibodies -- Health aspects ,Phosphatases -- Genetic aspects ,Phosphatases -- Health aspects ,Biotechnology industry -- Genetic aspects ,Biotechnology industry -- Health aspects ,Oncology, Experimental -- Prognosis ,Oncology, Experimental -- Development and progression ,Oncology, Experimental -- Genetic aspects ,Oncology, Experimental -- Health aspects ,Proteins -- Genetic aspects ,Proteins -- Health aspects ,Growth factors -- Genetic aspects ,Growth factors -- Health aspects ,Cancer -- Genetic aspects ,Cancer -- Care and treatment ,Cancer -- Prognosis ,Cancer -- Development and progression ,Cancer -- Health aspects ,Women -- Health aspects ,Women -- Genetic aspects ,Cancer -- Chemotherapy ,Cancer -- Research ,Health - Abstract
Abstract In nonsmall cell lung cancer (NSCLC), prognostic factors have been established including tumor stage and performance status, however, survival within the same stage is variable and additional prognostic factors [...]
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- 2007
7. Harvard University, U.S., scientists describe new study results
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Harvard University -- Reports ,Prostanoids -- Genetic aspects ,Prostanoids -- Reports ,Prostanoids -- Health aspects ,Oncology, Experimental -- Genetic aspects ,Oncology, Experimental -- Reports ,Oncology, Experimental -- Health aspects ,Scientists -- Genetic aspects ,Scientists -- Reports ,Scientists -- Health aspects ,Universities and colleges -- Genetic aspects ,Universities and colleges -- Reports ,Universities and colleges -- Health aspects ,Cancer -- Research ,Cancer -- Genetic aspects ,Cancer -- Reports ,Cancer -- Health aspects - Abstract
Harvard University, U.S., scientists describe new study results. This trend article about Harvard University, U.S., is an immediate alert from NewsRx to identify developing directions of research. Study 1: Fresh [...]
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- 2007
8. Reports describe recent advances in oncology research
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Cancer -- Reports ,Cancer -- Health aspects ,Cancer -- Genetic aspects ,Gene therapy -- Reports ,Gene therapy -- Health aspects ,Gene therapy -- Genetic aspects ,Prostanoids -- Reports ,Prostanoids -- Health aspects ,Prostanoids -- Genetic aspects ,Oncology, Experimental -- Reports ,Oncology, Experimental -- Health aspects ,Oncology, Experimental -- Genetic aspects ,Cancer -- Research - Abstract
Data on oncology are outlined in reports from Israel, the United States and Germany. Study 1: Herpes simplex virus thymidine kinase transduction expands colon cancer growth. "Transduction of tumor cells [...]
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- 2005
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