1. Novel prostanoid thromboxane A2 agonists.
- Author
-
Joachim KD, Klar U, Pletsch A, Rehwinkel H, and Skuballa W
- Subjects
- Blood Platelets metabolism, Cell Membrane metabolism, Humans, Platelet Aggregation drug effects, Prostaglandins D chemical synthesis, Receptors, Thromboxane metabolism, Prostaglandins D pharmacology, Thromboxane A2 agonists
- Abstract
The chemistry and biology of novel TXA2(TP)-receptor agonists based on the prostanoid skeleton is described and structure-activity-relationships are discussed. One compound,(5Z,13E), (9R,15R)-9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid (33), was identified which is 10 times more potent than the standard TP-receptor against U 46619.
- Published
- 1995
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