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The aim of this research was to give further evidence for the influence of vestibularand proprioceptive information on distance perception, and to verify how perceived distancechanges if we use matching versus verbal judgment task. That is, the aim was to investigate how perceived distance changes when we bend over and look between the legs. The experiment was performed on a daylight open field (full-cue situation), with 20 participants, high school students from the Petnica Science Center. Participants had the task to match distances of two stimuli, one of which was in front of them at eye level, whereas the other was behind them, and they could observe it by bending their body forward and looking between the legs .Stimuli were 7cm*5cm large, and rectangular in shape. Results have shown that perceived distance changes in such a way that distances observed between the legs are perceived as longer than distances observed from an upright position. This difference in perceived distances exists only for larger physical distances (3m and 5m), but not for smaller physical distances (1m. Results coincide with our previous findings which indicate that vestibular and proprioceptive information change elongates perceived distance. On the other hand, the results contradict some findings gained in experiments in which the verbal judgment task was used. These contrary results probably appear because the verbal judgment task leaves more space for higher cognitive processes to be involved.

Study Design: A population-based, cross-sectional study.Objective: The aim of this study was to quantitatively evaluate the relationship between static postural stability and fat infiltration within cervical multifidus muscle in patients with cervical spondylotic radiculopathy (CSR).Summary Of Background Data: CSR causes denervation by compression of nerve roots. This denervation is detected by fatty infiltration or results in fatty infiltration within muscles. Proprioceptive information in cervical multifidus muscle plays an important role in coordinated movement of postural stability; however, there have been few studies evaluating the relationship between postural stability and fat infiltration within cervical multifidus muscle among CSR patients.Methods: Sixteen CSR patients with C6 injuries and 25 age-matched healthy controls underwent magnetic resonance images to examine bilateral cervical multifidus muscle. For evaluation of fat within muscle, a muscle fat index (MFI) was calculated by using both measurement of cervical multifidus muscle and intermuscular fat. Participants' postural stability at upright position with eyes-opened and eyes-closed for 60 seconds was examined by a platform. Two parameters, the total length and the area of the center of pressure (COP), were used for evaluation.Results: The CSR group showed significantly poorer postural stability than the control group (eyes-opened the total length; P < 0.05, eyes-closed the total length; P < 0.05, eyes-closed the area; P < 0.05). There were significant group differences at C4, C5, and C6 MFI (P < 0.05). In the CSR group, a correlation analysis demonstrated that the age, C4, C5, and C6 MFI values were significantly associated with the eyes-closed the total length of the COP (P < 0.05).Conclusions: Fat infiltration within muscle could lead to inhibition of normal activity of musculature. The present study suggests that fat within cervical multifidus muscle could directly cause postural instability in static standing, even though the proprioceptive information has normal lower limbs. [ABSTRACT FROM AUTHOR]

Neuroimaging combined with transcranial magnetic stimulation (TMS) to primary motor cortex (M1) is an emerging technique that can examine motor-system functionality through evoked activity. However, because sensory afferents from twitching muscles are widely represented in motor areas the amount of evoked activity directly resulting from TMS remains unclear. We delivered suprathreshold TMS to left M1 or electrically stimulated the right median nerve (MNS) in 18 healthy volunteers while simultaneously conducting functional magnetic resonance imaging and monitoring with electromyography (EMG). We examined in detail the localization of TMS-, muscle afferent- and superficial afferent-induced activity in M1 subdivisions. Muscle afferent- and TMS-evoked activity occurred mainly in rostral M1, while superficial afferents generated a slightly different activation distribution. In 12 participants who yielded quantifiable EMG, differences in brain activity ascribed to differences in movement-size were adjusted using integrated information from the EMGs. Sensory components only explained 10-20% of the suprathreshold TMS-induced activity, indicating that locally and remotely evoked activity in motor areas mostly resulted from the recruitment of neural and synaptic activity. The present study appears to justify the use of fMRI combined with suprathreshold TMS to M1 for evoked motor network imaging.

Four experiments investigated how observers' consciousness about their control of stimulus change affects the visual perception associated with the illusory flash-lag effect. In previous study (Ichikawa & Masakura, 2006), we found that the flash-lag effect in motion is reduced if observers were conscious that they were controlling stimulus movements by the use of computer mouse, even if the stimulus moved automatically, independently of observer’s mouse control. In the other study (Ichikawa & Masakura, 2010a), we found that the consistent directional relationship between the observer’s mouse control and stimulus movement, which is learned in our everyday computer use, is important for the reduction of the flash-lag effect in active observation. In the present study, we examined whether the reduction of the flash-lag effect in active observation requires the observers’ consciousness about their control of stimulus change, and consistency in coupling mouse movement direction and stimulus change across trials in experiments. We used the flash-lag effect in luminance change because there is no intrinsic relationship between observer’s mouse control and luminance change in our everyday computer use. We compared the illusory flash-lag effects for automatic change of the luminance with luminance change that was controlled by the observers’ active manipulation of a computer mouse. Because the flash occurs randomly in time, observers could not anticipate when the flash was presented. Results suggest that the not only observer’s consciousness of controlling the stimulus, but also consistency in coupling mouse movement direction with stimulus change, are required for the reduction of the flash-lag effect in active observation. The basis of the reduction of the flash-lag effect in active observation is discussed.

The ankles play an important role in human balance. In most studies investigating balance control the contribution of the left and right leg is not separated. However, in certain pathologies such as stroke and Parkinson's disease, balance control can be asymmetric. Here, a bilateral ankle perturbator (BAP) is presented, which applies support surface rotations to both ankles independently. The device consists of two small foot-size support surfaces, which are independently actuated. The BAP device can operate in either angle or torque control mode. The device is able to apply support surface rotations up to 8.6° with a bandwidth of 42 Hz. Additionally the platforms can be replaced by 6-DoF force plates to measure the center of pressure underneath each foot. With the optional force plates the bandwidth decreases to 16 Hz as a result of the additional weight. Two possible applications of the device to investigate human balance control are demonstrated: ankle stiffness by applying minimum jerk profiles and sensory reweighting of the proprioceptive information. In conclusion, we developed a bilateral ankle perturbator which is able to apply support surface rotations to both ankles independently. The major application of the device will be to investigate the contribution of both ankles to human balance control, and the interactions in balance control between both legs. [ABSTRACT FROM AUTHOR]

Abstract: The perikarya of sensory neurons of the mesencephalic trigeminal nucleus (MTN) receive dense histaminergic hypothalamic innervation. In this study, we examine the yet unknown expression and localization of histamine receptors in the rat MTN using immunohistochemistry with subtype-specific antibodies. Same as the masticatory muscle spindle somata H1 receptors were located along the entire MTN, whereas H3 receptors were detected in the caudal pontine part of the nucleus, which receives input from periodontal afferents. Most of the immunostained cell bodies were surrounded by histidine decarboxylase-, histamine- or vesicular monoamine transporter 2-containing pericellular varicose fibers and terminals in a basket-like manner. Our results suggest that rat MTN neurons are directly influenced by histaminergic descending projections from the hypothalamus. It can be inferred that processing of proprioceptive information at the level of the MTN is controlled via histamine H1 and H3 receptors through different postsynaptic mechanisms. [Copyright &y& Elsevier]

Krox-20, a C2H2-type zinc-finger transcription factor, plays an important role in rhombomere development. This study reveals that the Krox-20 null mutation impacts the development of mesencephalic trigeminal (Me5) neurons, a cell group traditionally thought to emerge from the mesencephalon. Based on cell counting studies, we show that Krox-20 null mutants have twice as many Me5 neurons relative to wildtypes at E15, but by birth have half the number of Me5 cells as wildtypes. TUNEL studies reveal a period of increased apoptosis from E17-P0 in mutants. The mutation does not result in differences in Me5 cell size, morphology, gene expression or peripheral projection patterns between genotypes, as demonstrated by retrograde tracing and Brn3a immunohistochemistry. The data suggest that Krox-20 regulates the period and extent of Me5 apoptosis, impacting the final number of Me5 neurons. The loss of Me5 in Krox-20–/– mice may highlight species-specific differences in the origin of these cells. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Previous findings have demonstrated the existence of a visual peripersonal space centered on the hand in humans and its modulatory effects on tactile perception. A strong modulatory effect of vision on touch perception was found when a visual stimulus was presented near the hand. In contrast, when the visual stimulus was presented far from the hand, only a weak modulatory effect was found. The aim of the present study was to verify whether such cross-modal links between touch and vision in the peripersonal space centered on the hand could be mediated by proprioceptive signals specifying the current hand positions or if they directly reflect an interaction between two sensory modalities, i.e., vision and touch. To this aim, cross-modal effects were studied in two different experiments: one in which patients could see their hands and one in which vision of their hands was prevented. The results showed strong modulatory effects of vision on touch perception when the visual stimulus was presented near the seen hand and only mild effects when the vision of the hand was prevented. These findings are explained by referring to the activity of bimodal neurons in premotor and parietal cortex of macaque, which have tactile receptive fields on the hand, and corresponding visual receptive fields in the space immediately adjacent to the tactile fields. One important feature of these bimodal neurons is that their responsiveness to visual stimuli delivered near the body part is reduced or even extinguished when the view of the body part is prevented. This implies that, at least for the hand, the vision of the hand is crucial for determining the spatial mapping between vision and touch that takes place in the peripersonal space. In contrast, the proprioceptive signals specifying the current hand position in space do not seem to be relevant in determining the cross-modal interaction between vision and touch. [ABSTRACT FROM AUTHOR]

A previous study on neglect suggested that at least two hand parameters are crucial in producing an amelioration of neglect: the hand (left or right) and the spatial position of the hand (left or right). The improvement observed in perceiving left targets when the left hand acts in the left space can be due either to proprioceptive or to visual cuing. The stimulated left hand located in the left space may act as a powerful visual cue for the enhancement of the left visuo-spatial representation, in the same way as any other visual stimulus presented in the periphery of the visual field. Alternatively, it may be that the perceived hand location (due to the activation of the proprioceptive system) acts as an attentional field able to enhance the representation of the left space. In order to disentangle these two hypotheses, in the present study a naming task was executed by a group of neglect patients and by a control group. The subjects had to name all the objects depicted on a sheet of paper which were reflected on a mirror that inverted right and left space. While doing the naming performance, the subjects passively moved either the right or the left hand, in the left or right space. Stimuli and hand were reflected in the mirror that inverted right and left space and direct view of the stimuli and of the stimulated hand was prevented by a board. The results show that patients were more accurate at naming stimuli reflected in the left side of the mirror when the left hand was located and moved on the left side. In this condition, however, the left hand was seen in the right side of the mirror. It is therefore clear that the better performance was not due to visuo-spatial cuing but to a proprioceptive cuing effect. The results are discussed in terms of the relevance of personal and peripersonal spatial activation in the modulation of extrapersonal visual neglect. The coactivation of different spatial representations seems to be very influential on stimulus coding, thus confirming that spatial awareness is strictly related to the joint activity of multiple brain maps. [ABSTRACT FROM AUTHOR]

Four experiments investigated how observers' consciousness about their control of stimulus change affects the visual perception associated with the illusory flash-lag effect. In previous study (Ichikawa and Masakura, 2006), we found that the flash-lag effect in motion is reduced if observers were conscious that they were controlling stimulus movements by the use of computer mouse, even if the stimulus moved automatically, independently of observer's mouse control. In the other study (Ichikawa and Masakura, 2010a), we found that the consistent directional relationship between the observer's mouse control and stimulus movement, which is learned in our everyday computer use, is important for the reduction of the flash-lag effect in active observation. In the present study, we examined whether the reduction of the flash-lag effect in active observation requires the observers' consciousness about their control of stimulus change, and consistency in coupling mouse movement direction and stimulus change across trials in experiments. We used the flash-lag effect in luminance change because there is no intrinsic relationship between observer's mouse control and luminance change in our everyday computer use. We compared the illusory flash-lag effects for automatic change of the luminance with luminance change that was controlled by the observers' active manipulation of a computer mouse. Because the flash occurs randomly in time, observers could not anticipate when the flash was presented. Results suggest that the not only observer's consciousness of controlling the stimulus, but also consistency in coupling mouse movement direction with stimulus change, are required for the reduction of the flash-lag effect in active observation. The basis of the reduction of the flash-lag effect in active observation is discussed.