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1. Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease

Author

Rosenzweig, Neta, Kleemann, Kilian L., Rust, Thomas, Carpenter, Madison, Grucci, Madeline, Aronchik, Michael, Brouwer, Nieske, Valenbreder, Isabel, Cooper-Hohn, Joya, Iyer, Malvika, Krishnan, Rajesh K., Sivanathan, Kisha N., Brandão, Wesley, Yahya, Taha, Durao, Ana, Yin, Zhuoran, Chadarevian, Jean Paul, Properzi, Michael J., Nowarski, Roni, Davtyan, Hayk, Weiner, Howard L., Blurton-Jones, Mathew, Yang, Hyun-Sik, Eggen, Bart J. L., Sperling, Reisa A., and Butovsky, Oleg

Published
2024
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2. Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration

Author

Boyle, Rory, Townsend, Diana L., Klinger, Hannah M., Scanlon, Catherine E., Yuan, Ziwen, Coughlan, Gillian T., Seto, Mabel, Shirzadi, Zahra, Yau, Wai-Ying Wendy, Jutten, Roos J., Schneider, Christoph, Farrell, Michelle E., Hanseeuw, Bernard J., Mormino, Elizabeth C., Yang, Hyun-Sik, Papp, Kathryn V., Amariglio, Rebecca E., Jacobs, Heidi I. L., Price, Julie C., Chhatwal, Jasmeer P., Schultz, Aaron P., Properzi, Michael J., Rentz, Dorene M., Johnson, Keith A., Sperling, Reisa A., Hohman, Timothy J., Donohue, Michael C., and Buckley, Rachel F.

Published
2024
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4. Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer's Disease

Author

Jutten, Roos J, Rentz, Dorene M, Fu, Jessie F, Mayblyum, Danielle V, Amariglio, Rebecca E, Buckley, Rachel F, Properzi, Michael J, Maruff, Paul, Stark, Craig E, Yassa, Michael A, Johnson, Keith A, Sperling, Reisa A, and Papp, Kathryn V

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Neurodegenerative, Alzheimer's Disease, Clinical Research, Aging, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Brain Disorders, Dementia, Neurological, computerized testing, remote assessment, practice effects, digital biomarkers, preclinical AD, Biochemistry and Cell Biology, Cognitive Sciences, Biological psychology
Abstract

Introduction: We investigated whether monthly assessments of a computerized cognitive composite (C3) could aid in the detection of differences in practice effects (PE) in clinically unimpaired (CU) older adults, and whether diminished PE were associated with Alzheimer's disease (AD) biomarkers and annual cognitive decline. Materials and Methods: N = 114 CU participants (age 77.6 ± 5.0, 61% female, MMSE 29 ± 1.2) from the Harvard Aging Brain Study completed the self-administered C3 monthly, at-home, on an iPad for one year. At baseline, participants underwent in-clinic Preclinical Alzheimer's Cognitive Composite-5 (PACC5) testing, and a subsample (n = 72, age = 77.8 ± 4.9, 59% female, MMSE 29 ± 1.3) had 1-year follow-up in-clinic PACC5 testing available. Participants had undergone PIB-PET imaging (0.99 ± 1.6 years before at-home baseline) and Flortaucipir PET imaging (n = 105, 0.62 ± 1.1 years before at-home baseline). Linear mixed models were used to investigate change over months on the C3 adjusting for age, sex, and years of education, and to extract individual covariate-adjusted slopes over the first 3 months. We investigated the association of 3-month C3 slopes with global amyloid burden and tau deposition in eight predefined regions of interest, and conducted Receiver Operating Characteristic analyses to examine how accurately 3-month C3 slopes could identify individuals that showed >0.10 SD annual decline on the PACC-5. Results: Overall, individuals improved on all C3 measures over 12 months (β = 0.23, 95% CI [0.21-0.25], p < 0.001), but improvement over the first 3 months was greatest (β = 0.68, 95% CI [0.59-0.77], p < 0.001), suggesting stronger PE over initial repeated exposures. However, lower PE over 3 months were associated with more global amyloid burden (r = -0.20, 95% CI [-0.38 - -0.01], p = 0.049) and tau deposition in the entorhinal cortex (r = -0.38, 95% CI [-0.54 - -0.19], p < 0.001) and inferior-temporal lobe (r = -0.23, 95% CI [-0.41 - -0.02], p = 0.03). 3-month C3 slopes exhibited good discriminative ability to identify PACC-5 decliners (AUC 0.91, 95% CI [0.84-0.98]), which was better than baseline C3 (p < 0.001) and baseline PACC-5 scores (p = 0.02). Conclusion: While PE are commonly observed among CU adults, diminished PE over monthly cognitive testing are associated with greater AD biomarker burden and cognitive decline. Our findings imply that unsupervised computerized testing using monthly retest paradigms can provide rapid detection of diminished PE indicative of future cognitive decline in preclinical AD.

Published
2022

6. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography

Author

Sanchez, Justin S, Becker, J Alex, Jacobs, Heidi IL, Hanseeuw, Bernard J, Jiang, Shu, Schultz, Aaron P, Properzi, Michael J, Katz, Samantha R, Beiser, Alexa, Satizabal, Claudia L, O'Donnell, Adrienne, DeCarli, Charles, Killiany, Ron, El Fakhri, Georges, Normandin, Marc D, Gómez-Isla, Teresa, Quiroz, Yakeel T, Rentz, Dorene M, Sperling, Reisa A, Seshadri, Sudha, Augustinack, Jean, Price, Julie C, and Johnson, Keith A

Subjects
Medical Biotechnology, Engineering, Biomedical and Clinical Sciences, Biomedical Engineering, Brain Disorders, Alzheimer's Disease, Aging, Prevention, Neurodegenerative, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Acquired Cognitive Impairment, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adult, Alzheimer Disease, Amyloid beta-Peptides, Humans, Positron-Emission Tomography, Tauopathies, tau Proteins, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

Advances in molecular positron emission tomography (PET) have enabled anatomic tracking of brain pathology in longitudinal studies of normal aging and dementia, including assessment of the central model of Alzheimer's disease (AD) pathogenesis, according to which TAU pathology begins focally but expands catastrophically under the influence of amyloid-β (Aβ) pathology to mediate neurodegeneration and cognitive decline. Initial TAU deposition occurs many years before Aβ in a specific area of the medial temporal lobe. Building on recent work that enabled focus of molecular PET measurements on specific TAU-vulnerable convolutional temporal lobe anatomy, we applied an automated anatomic sampling method to quantify TAU PET signal in 443 adult participants from several observational studies of aging and AD, spanning a wide range of ages, Aβ burdens, and degrees of clinical impairment. We detected initial cortical emergence of tauopathy near the rhinal sulcus in clinically normal people and, in a subset with longitudinal 2-year follow-up data (n = 104), tracked Aβ-associated spread of TAU from this site first to nearby neocortex of the temporal lobe and then to extratemporal regions. Greater rate of TAU spread was associated with baseline measures of both global Aβ burden and medial temporal lobe TAU. These findings are consistent with clinicopathological correlation studies of Alzheimer's tauopathy and enable precise tracking of AD-related TAU progression for natural history studies and prevention therapeutic trials.

Published
2021

7. Decline in cognitively complex everyday activities accelerates along the Alzheimer’s disease continuum

Author

Dubbelman, Mark A, Jutten, Roos J, Tomaszewski Farias, Sarah E, Amariglio, Rebecca E, Buckley, Rachel F, Visser, Pieter Jelle, Rentz, Dorene M, Johnson, Keith A, Properzi, Michael J, Schultz, Aaron, Donovan, Nancy, Gatchell, Jennifer R, Teunissen, Charlotte E, Van Berckel, Bart NM, Van der Flier, Wiesje M, Sperling, Reisa A, Papp, Kathryn V, Scheltens, Philip, Marshall, Gad A, and Sikkes, Sietske AM

Subjects
Health Services and Systems, Health Sciences, Aging, Neurosciences, Rehabilitation, Alzheimer's Disease, Dementia, Neurodegenerative, Acquired Cognitive Impairment, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Research, Behavioral and Social Science, Neurological, Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Cognitive Dysfunction, Disease Progression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prodromal Symptoms, Alzheimer&#8217, s disease, functional impairment, instrumental activities of daily living, clinical stages, Alzheimer Disease Neuroimaging Initiative, National Alzheimer’s Coordinating Center, the Harvard Aging Brain Study, the Alzheimer Dementia Cohort, Alzheimer’s disease, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundImpairment in daily functioning is a clinical hallmark of dementia. Difficulties with "instrumental activities of daily living" (IADL) seem to increase gradually over the course of Alzheimer's disease (AD), before dementia onset. However, it is currently not well established how difficulties develop along the preclinical and prodromal stages of AD. We aimed to investigate the trajectories of decline in IADL performance, as reported by a study partner, along the early stages of AD.MethodsIn a longitudinal multicenter study, combining data from community-based and memory clinic cohorts, we included 1555 individuals (mean age 72.5 ± 7.8 years; 50% female) based on availability of amyloid biomarkers, longitudinal IADL data, and clinical information at baseline. Median follow-up duration was 2.1 years. All amyloid-positive participants (n = 982) were classified into the National Institute on Aging-Alzheimer's Association (NIA-AA) clinical stages ranging from preclinical AD (1) to overt dementia (4+). Cognitively normal amyloid-negative individuals (n = 573) served as a comparison group. The total scores of three study-partner reported IADL questionnaires were standardized.ResultsThe rate of decline in cognitively normal (stage 1) individuals with and without abnormal amyloid did not differ (p = .453). However, from stage 2 onwards, decline was significantly faster in individuals on the AD continuum (B [95%CI] = - 0.32 [- 0.55, - 0.09], p = .007). The rate of decline increased with each successive stage: one standard deviation (SD) unit per year in stage 3 (- 1.06 [- 1.27, - 0.85], p

Published
2020

8. Amyloid and tau burden relate to longitudinal changes in the performance of complex everyday activities among cognitively unimpaired older adults: results from the performance-based Harvard Automated Phone Task

Author

Dubbelman, Mark A., primary, Diez, Ibai, additional, Gonzalez, Christopher, additional, Amariglio, Rebecca E., additional, Becker, J. Alex, additional, Chhatwal, Jasmeer P., additional, Gatchel, Jennifer R., additional, Johnson, Keith A., additional, Locascio, Joseph J., additional, Udeogu, Onyinye J., additional, Wang, Sharon, additional, Papp, Kathryn V., additional, Properzi, Michael J., additional, Rentz, Dorene M., additional, Schultz, Aaron P., additional, Sperling, Reisa A., additional, Vannini, Patrizia, additional, and Marshall, Gad A., additional

Published
2024
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9. Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults

Author

Rodriguez-Vieitez, Elena, Montal, Victor, Sepulcre, Jorge, Lois, Cristina, Hanseeuw, Bernard, Vilaplana, Eduard, Schultz, Aaron P., Properzi, Michael J., Scott, Matthew R., Amariglio, Rebecca, Papp, Kathryn V., Marshall, Gad A., Fortea, Juan, Johnson, Keith A., Sperling, Reisa A., and Vannini, Patrizia

Published
2021
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10. Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard Aging Brain Study.

Author

Shirzadi, Zahra, Boyle, Rory, Yau, Wai-Ying W, Coughlan, Gillian, Fu, Jessie Fanglu, Properzi, Michael J, Buckley, Rachel F, Yang, Hyun-Sik, Scanlon, Catherine E, Hsieh, Stephanie, Amariglio, Rebecca E, Papp, Kathryn, Rentz, Dorene, Price, Julie C, Johnson, Keith A, Sperling, Reisa A, Chhatwal, Jasmeer P, and Schultz, Aaron P

Abstract

In addition to amyloid and tau pathology, elevated systemic vascular risk, white matter injury, and reduced cerebral blood flow contribute to late-life cognitive decline. Given the strong collinearity among these parameters, we proposed a framework to extract the independent latent features underlying cognitive decline using the Harvard Aging Brain Study (N = 166 cognitively unimpaired older adults at baseline). We used the following measures from the baseline visit: cortical amyloid, inferior temporal cortex tau, relative cerebral blood flow, white matter hyperintensities, peak width of skeletonized mean diffusivity, and Framingham Heart Study cardiovascular disease risk. We used exploratory factor analysis to extract orthogonal factors from these variables and their interactions. These factors were used in a regression model to explain longitudinal Preclinical Alzheimer Cognitive Composite-5 (PACC) decline (follow-up = 8.5 ±2.7 years). We next examined whether gray matter volume atrophy acts as a mediator of factors and PACC decline. Latent factors of systemic vascular risk, white matter injury, and relative cerebral blood flow independently explain cognitive decline beyond amyloid and tau. Gray matter volume atrophy mediates these associations with the strongest effect on white matter injury. These results suggest that systemic vascular risk contributes to cognitive decline beyond current markers of cerebrovascular injury, amyloid, and tau. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Preliminary evaluation of the digital maze test in relation to neuropsychological tests and AD biomarkers

Author

Robinson, Talia L, primary, Fu, Jessie Fanglu, additional, Montenegro, Grace A Del Carmen, additional, Properzi, Michael J, additional, Klinger, Hannah M, additional, Penney, Dana, additional, Davis, Randall, additional, Sperling, Reisa A., additional, Johnson, Keith A., additional, Amariglio, Rebecca E., additional, and Rentz, Dorene M., additional

Published
2023
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15. Defining and characterizing neocortical tau resistance in preclinical Alzheimer’s Disease

Author

Properzi, Michael J, primary, Townsend, Diana, additional, Klinger, Hannah M, additional, Boyle, Rory, additional, Coughlan, Gillian T, additional, Hanseeuw, Bernard J, additional, Amariglio, Rebecca E., additional, Rentz, Dorene M., additional, Jacobs, Heidi I.L., additional, Price, Julie C, additional, Chhatwal, Jasmeer P., additional, Schultz, Aaron P., additional, Hohman, Timothy J., additional, Donohue, Michael C., additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, and Buckley, Rachel F., additional

Published
2023
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16. Predicting change in depressive symptoms using longitudinal regional amyloid and cognition in cognitively unimpaired older adults

Author

Munro, Catherine E, primary, Farrell, Michelle E., additional, Hanseeuw, Bernard J, additional, Rentz, Dorene M., additional, Buckley, Rachel F., additional, Properzi, Michael J, additional, Vannini, Patrizia, additional, Amariglio, Rebecca E., additional, Quiroz, Yakeel T., additional, Blacker, Deborah, additional, Sperling, Reisa A., additional, Johnson, Keith A., additional, Marshall, Gad A, additional, and Gatchel, Jennifer, additional

Published
2023
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17. Sex differences in plasma p‐tau181 accumulation is associated with subsequent tau‐PET signal

Author

Hsieh, Stephanie, primary, Townsend, Diana, additional, Coughlan, Gillian T, additional, Boyle, Rory, additional, Klinger, Hannah M, additional, Seto, Mabel, additional, Hanseeuw, Bernard J, additional, Yang, Hyun‐Sik, additional, Amariglio, Rebecca E., additional, Hassenstab, Jason J., additional, Hohman, Timothy J., additional, James, Bryan D, additional, Risacher, Shannon L, additional, Properzi, Michael J, additional, Schultz, Aaron P., additional, Baker, Suzanne L., additional, Sperling, Reisa A., additional, and Buckley, Rachel F., additional

Published
2023
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18. Associations among depressive symptoms, hippocampal volume and cognition in community‐dwelling older Latinos

Author

Giudicessi, Averi, primary, Gatchel, Jennifer, additional, Vila‐Castelar, Clara, additional, Ramirez‐Gomez, Liliana A., additional, Aduen, Paula, additional, Noriega, Daisy, additional, Félix, Nikole A Bonillas, additional, Kaplan, Elizabeth, additional, Martinez, Jairo E., additional, Fabrega, Sofia, additional, Castillo, Crystal, additional, Badillo‐Cabrera, Alex L, additional, Garza‐Naveda, Ana Paola, additional, Garcia, Kelly A. Lopez, additional, Properzi, Michael J, additional, Kirn, Dylan, additional, Amariglio, Rebecca E., additional, Rentz, Dorene M., additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, and Quiroz, Yakeel T., additional

Published
2023
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19. Glucose hypometabolism is associated with brain pathology and cognitive‐behavioral symptoms in autosomal dominant Alzheimer’s disease: Findings from the Colombia‐Boston (COLBOS) Biomarker Study

Author

Langella, Stephanie, primary, Kaplan, Elizabeth, additional, Baena, Ana Y., additional, Londono, Natalia, additional, Munera, Diana, additional, Vila‐Castelar, Clara, additional, Alvarez, Sergio, additional, Vidal, Monica, additional, Properzi, Michael J, additional, Sanchez, Justin S, additional, Sperling, Reisa A., additional, Johnson, Keith A., additional, Lopera, Francisco, additional, Hanseeuw, Bernard J, additional, and Quiroz, Yakeel T., additional

Published
2023
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21. The Mobile Toolbox for assessing cognition in older adults: associations with standardized cognitive testing and amyloid and tau PET

Author

Jutten, Roos J., primary, Burling, Jessa, additional, Campbell, Emily C, additional, Roy, Chloe, additional, Properzi, Michael J, additional, Amariglio, Rebecca E., additional, Marshall, Gad A, additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, Papp, Kathryn V., additional, and Rentz, Dorene M., additional

Published
2023
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22. Systemic vascular risk, white matter injury, and relative cerebral blood flow independently contribute to cognitive decline beyond amyloid and tau burden

Author

Shirzadi, Zahra, primary, Yau, Wai‐Ying Wendy, additional, Boyle, Rory, additional, Properzi, Michael J, additional, Buckley, Rachel F., additional, Yang, Hyun‐Sik, additional, Scanlon, Catherine E, additional, Hsieh, Stephanie, additional, Amariglio, Rebecca E., additional, Papp, Kathryn V., additional, Rentz, Dorene M., additional, Price, Julie C, additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, Chhatwal, Jasmeer P., additional, and Schultz, Aaron P., additional

Published
2023
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24. Examining the influence of changes in amyloid burden on both contemporaneous and subsequent cognitive decline: using a latent change score approach

Author

Klinger, Hannah M, primary, Healy, Brian, additional, Hanseeuw, Bernard J, additional, Jones, Rich, additional, Townsend, Diana, additional, Properzi, Michael J, additional, Farrell, Michelle E., additional, Papp, Kathryn V., additional, Chhatwal, Jasmeer P., additional, Yang, Hyun‐Sik, additional, Schultz, Aaron P., additional, Amariglio, Rebecca E., additional, Jacobs, Heidi I.L., additional, Price, Julie C, additional, Johnson, Keith A., additional, Rentz, Dorene M., additional, Sperling, Reisa A., additional, and Buckley, Rachel F., additional

Published
2023
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25. Estimating a clinically normal individual’s position along a preclinical Alzheimer’s disease continuum using cognitive and amyloid trajectories

Author

Townsend, Diana, primary, Properzi, Michael J, additional, Betthauser, Tobey J, additional, Klinger, Hannah M, additional, Boyle, Rory, additional, Coughlan, Gillian T, additional, Hanseeuw, Bernard J, additional, Yang, Hyun‐Sik, additional, Amariglio, Rebecca E., additional, Farrell, Michelle E., additional, Jacobs, Heidi I.L., additional, Shirzadi, Zahra, additional, Yau, Wai‐Ying Wendy, additional, Price, Julie C, additional, Chhatwal, Jasmeer P., additional, Rentz, Dorene M., additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, Schultz, Aaron P., additional, and Buckley, Rachel F., additional

Published
2023
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29. 84 Feasibility and Validity of Remote Digital Assessment of Multi-Day Learning in Cognitively Unimpaired Older Adults

Author

Weizenbaum, Emma L., primary, Soberanes, Daniel, additional, Hsieh, Stephanie, additional, Schneider, Olivia R, additional, Srinivasan, Shruthi, additional, Buckley, Rachel F, additional, Properzi, Michael J, additional, Rentz, Dorene, additional, Johnson, Keith A, additional, Sperling, Reisa A, additional, Papp, Kathryn V, additional, and Amariglio, Rebecca E, additional

Published
2023
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30. Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal

Author

Scott, Matthew R, primary, Edwards, Natalie C, additional, Properzi, Michael J, additional, Jacobs, Heidi IL, additional, Price, Julie C, additional, Lois, Cristina, additional, Farrell, Michelle E, additional, Hanseeuw, Bernard J, additional, Thibault, Emma G, additional, Rentz, Dorene M, additional, Johnson, Keith A, additional, Sperling, Reisa A, additional, Schultz, Aaron P, additional, and Buckley, Rachel F, additional

Published
2023
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31. Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts

Author

Buckley, Rachel F., Mormino, Elizabeth C., Amariglio, Rebecca E., Properzi, Michael J., Rabin, Jennifer S., Lim, Yen Ying, Papp, Kathryn V., Jacobs, Heidi I.L., Burnham, Samantha, Hanseeuw, Bernard J., Doré, Vincent, Dobson, Annette, Masters, Colin L., Waller, Michael, Rowe, Christopher C., Maruff, Paul, Donohue, Michael C., Rentz, Dorene M., Kirn, Dylan, Hedden, Trey, Chhatwal, Jasmeer, Schultz, Aaron P., Johnson, Keith A., Villemagne, Victor L., and Sperling, Reisa A.

Published
2018
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33. Longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: Findings from the Alzheimer's Disease Neuroimaging Initiative.

Author

Premnath, Pranitha Y., Locascio, Joseph J., Mimmack, Kayden J., Gonzalez, Christopher, Properzi, Michael J., Udeogu, Onyinye, Rosenberg, Paul B., Marshall, Gad A., and Gatchel, Jennifer R.

Subjects
ALZHEIMER'S disease, MILD cognitive impairment, TAU proteins, POSITRON emission tomography, APATHY
Abstract

Introduction: It is important to study apathy in Alzheimer's disease (AD) to better understand its underlying neurobiology and develop effective interventions. In the current study, we sought to examine the relationships between longitudinal apathy and regional tau burden in cognitively impaired older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Methods: Three hundred and nineteen ADNI participants with mild cognitive impairment (MCI) or AD dementia underwent flortaucipir (FTP) tau positron emission tomography (PET) imaging and clinical assessment with the Neuropsychiatric Inventory (NPI) annually. Longitudinal NPI Apathy (NPI‐A) scores were examined in relation to baseline tau PET signal in three a priori selected regions implicated in AD and AD‐related apathy (supramarginal gyrus, entorhinal cortex [EC] and rostral anterior cingulate cortex [rACC]). Secondary models were adjusted for global cognition (Mini‐Mental State Examination score) and cortical amyloid (florbetapir PET). Results: Higher baseline supramarginal gyrus and EC tau burden were each significantly associated with greater NPI‐A over time, while rACC tau was associated with higher NPI‐A but did not predict its trajectory over time. These results were retained for supramarginal and EC tau after adjusting models for global cognition and cortical amyloid. Discussion: Our findings suggest that baseline in vivo tau burden in parietal and temporal brain regions affected in AD, and less so in a medial frontal region involved in motivational control, is associated with increasing apathy over time in older adults with MCI and AD dementia. Future work studying emergent apathy in relation to not only core AD pathology but also circuit level dysfunction may provide additional insight into the neurobiology of apathy in AD and opportunities for intervention. Highlights: Tau (Flortaucipir PET) in regions implicated in AD was associated with increasing apathy over timeCortical amyloid was also found to be a robust predictor of the trajectory of apathyEvidence of synergy between regional tau and amyloid in overall higher levels of apathy [ABSTRACT FROM AUTHOR]

Published
2024
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34. Associations of the Harvard Automated Phone Task and Alzheimer’s Disease Pathology in Cognitively Normal Older Adults: Preliminary Findings

Author

Gonzalez, Christopher, primary, Mimmack, Kayden J., additional, Amariglio, Rebecca E., additional, Becker, J. Alex, additional, Chhatwal, Jasmeer P., additional, Fitzpatrick, Colleen D., additional, Gatchel, Jennifer R., additional, Johnson, Keith A., additional, Katz, Zoe S., additional, Kuppe, Madeline K., additional, Locascio, Joseph J., additional, Udeogu, Onyinye J., additional, Papp, Kathryn V., additional, Premnath, Pranitha, additional, Properzi, Michael J., additional, Rentz, Dorene M., additional, Schultz, Aaron P., additional, Sperling, Reisa A., additional, Vannini, Patrizia, additional, Wang, Sharon, additional, and Marshall, Gad A., additional

Published
2023
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37. Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex

Author

Hanseeuw, Bernard, primary, Jacobs, Heidi I.L., additional, Schultz, Aaron P, additional, Buckley, Rachel F., additional, Properzi, Michael J, additional, Becker, Alex, additional, Farrell, Michelle E., additional, Sanchez, Justin S, additional, Papp, Kathryn V., additional, Yang, Hyun‐Sik, additional, Chhatwal, Jasmeer P., additional, Price, Julie C, additional, Fakhri, Georges El, additional, Rentz, Dorene M., additional, Sperling, Reisa A., additional, and Johnson, Keith A., additional

Published
2022
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39. Microglia‐specific Alzheimer’s disease polygenic risk score is associated with amyloid‐β, tau, and microglial activation

Author

Yang, Hyun‐Sik, primary, Teng, Ling, additional, Kang, Daniel, additional, Menon, Vilas, additional, Ge, Tian, additional, Finucane, Hilary, additional, Schultz, Aaron P., additional, Properzi, Michael J, additional, Klein, Hans‐Ulrich, additional, Chibnik, Lori B., additional, Schneider, Julie A, additional, Bennett, David A, additional, Hohman, Timothy J., additional, Mayeux, Richard, additional, Johnson, Keith A., additional, De Jager, Philip L, additional, and Sperling, Reisa A., additional

Published
2022
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40. The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults

Author

Gagliardi, Geoffroy Pierre, primary, Rodriguez‐Vieitez, Elena, additional, Montal, Victor, additional, Sepulcre, Jorge, additional, Diez, Ibai Palacio, additional, Lois, Cristina, additional, Hanseeuw, Bernard, additional, Schultz, Aaron P., additional, Properzi, Michael J, additional, Papp, Kathryn V., additional, Marshall, Gad A, additional, Fortea, Juan, additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, and Vannini, Patrizia, additional

Published
2022
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41. Cerebrovascular injury markers explain the effect of systemic vascular risk on cognitive decline in older adults with lower amyloid burden

Author

Shirzadi, Zahra, primary, Yau, Wai‐Ying Wendy, additional, Rabin, Jennifer S., additional, Buckley, Rachel F., additional, Properzi, Michael J, additional, Fu, Jessie Fanglu, additional, Hsieh, Stephanie, additional, Thibault, Emma G., additional, Mojiri‐Forooshani, Parisa, additional, Goubran, Maged, additional, MacIntosh, Bradley J., additional, Black, Sandra E., additional, Price, Julie C, additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, Chhatwal, Jasmeer P., additional, and Schultz, Aaron P., additional

Published
2022
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42. Menopause age and hormone therapy use moderate PET tau and amyloid association: findings from the Wisconsin Registry for Alzheimer Prevention

Author

Coughlan, Gillian T, primary, Koscik, Rebecca Langhough, additional, Betthauser, Tobey J, additional, Boyle, Rory Thomas, additional, Jonaitis, Erin M., additional, Wenzel, Allen, additional, Christian, Bradley T, additional, Gleason, Carey E., additional, Klinger, Hannah, additional, Properzi, Michael J, additional, Schultz, Aaron P., additional, Hanseeuw, Bernard J, additional, Rentz, Dorene M., additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, Johnson, Sterling C., additional, and Buckley, Rachel F., additional

Published
2022
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45. Tau Mediates Synergistic Influence of Vascular Risk and Aβ on Cognitive Decline

Author

Yau, Wai‐Ying Wendy, primary, Shirzadi, Zahra, additional, Yang, Hyun‐Sik, additional, Ikoba, Akpevweoghene P., additional, Rabin, Jennifer S., additional, Properzi, Michael J., additional, Kirn, Dylan R., additional, Schultz, Aaron P., additional, Rentz, Dorene M., additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, and Chhatwal, Jasmeer P., additional

Published
2022
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46. Harmonizing the preclinical Alzheimer cognitive composite for multicohort studies.

Author

Hampton, Olivia L., primary, Mukherjee, Shubhabrata, additional, Properzi, Michael J., additional, Schultz, Aaron P., additional, Crane, Paul K., additional, Gibbons, Laura E., additional, Hohman, Timothy J., additional, Maruff, Paul, additional, Lim, Yen Ying, additional, Amariglio, Rebecca E., additional, Papp, Kathryn V., additional, Johnson, Keith A., additional, Rentz, Dorene M., additional, Sperling, Reisa A., additional, and Buckley, Rachel F., additional

Published
2022
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47. Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography.

Author

Coughlan, Gillian T., Betthauser, Tobey J., Boyle, Rory, Koscik, Rebecca L., Klinger, Hannah M., Chibnik, Lori B., Jonaitis, Erin M., Yau, Wai-Ying Wendy, Wenzel, Allen, Christian, Bradley T., Gleason, Carey E., Saelzler, Ursula G., Properzi, Michael J., Schultz, Aaron P., Hanseeuw, Bernard J., Manson, JoAnn E., Rentz, Dorene M., Johnson, Keith A., Sperling, Reisa, and Johnson, Sterling C.

Published
2023
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48. Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults

Author

Farrell, Michelle E., primary, Papp, Kathryn V., additional, Buckley, Rachel F., additional, Jacobs, Heidi I.L., additional, Schultz, Aaron P., additional, Properzi, Michael J., additional, Vannini, Patrizia, additional, Hanseeuw, Bernard J., additional, Rentz, Dorene M., additional, Johnson, Keith A., additional, and Sperling, Reisa A., additional

Published
2022
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49. Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer's Disease

Author

Jutten, Roos J., primary, Rentz, Dorene M., additional, Fu, Jessie F., additional, Mayblyum, Danielle V., additional, Amariglio, Rebecca E., additional, Buckley, Rachel F., additional, Properzi, Michael J., additional, Maruff, Paul, additional, Stark, Craig E., additional, Yassa, Michael A., additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, and Papp, Kathryn V., additional

Published
2022
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50. Associations between remote cognitive testing on an individual’s own digital device and amyloid burden on neuroimaging in clinically normal older adults: Results from Boston Remote Assessment for Neurocognitive Health (BRANCH)

Author

Papp, Kate V., primary, Rentz, Dorene M., additional, Buckley, Rachel F., additional, Schneider, Olivia R, additional, Hsieh, Stephanie, additional, Soberanes, Daniel, additional, Properzi, Michael J, additional, Schultz, Aaron P., additional, Johnson, Keith A., additional, Sperling, Reisa A., additional, and Amariglio, Rebecca E., additional

Published
2021
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