Search

Your search keyword '"Pronin, Vyacheslav"' showing total 17 results
Start Over Author "Pronin, Vyacheslav"

Refine your results

more »

more »
17 results on '"Pronin, Vyacheslav"'

6. Cardiovascular complications in pituitary gigantism (results of an international study)

Author

Rostomyan Liliya, Daly Adrian, Shah Nalini, A Naves Luciana, Barlier Anne, Jaffrain-Rea Marie-Lise, Emy Philippe, Neggers Sebastian, Santamaria Beatriz Lecumberri, Holdaway Ian, Brue Thierry, Stalla Gunter, Salvatori Roberto, Bertherat Jerome Yves, Maiter Dominique, Zacharin Margaret, Lila Anurag, Filipponi Silvia, Mukhopadhyay Satinath, Ebeling Tapani, Ojaniemi Marja, McCormack Ann I, Kuismin Outi, Lecoq Anne-Lise, Sahnoun-Fathallah Mona, Jung-Sievers Caroline, Malchiodi Elena, Rozhinskaya Liudmila, Nazzari Elena, Mittal Sachin, Verrua Elisa, Sorkina Ekaterina, Dreval Alexander, Devuyst France, Bilbao Ismene, Auriemma Renata Simona, Garcia Nuria Palacios, Ilovaiskaya Irena, Pronin Vyacheslav, Colao Annamaria, Ferone Diego, Spada Anna, Petrossians Patrick, Beck-Peccoz Paolo, Stratakis Constantine A, Chanson Philippe, and Beckers Albert

Subjects
Pituitary Gigantism, business.industry, Physiology, Medicine, business, Gigantism
Published
2018

7. The assessment of octreotide suppression test, ihc- and mr-structure, mr-signal of gh-producing pituitary adenoma for determining the prognosis of disease and management.

Author

Pronin, Vyacheslav, primary, Zherebchikova, Kristina, additional, Malysheva, Alena, additional, Kozhevnikov, Alexander, additional, Kalinin, Pavel, additional, Astafina, Lyudmila, additional, Rotin, Daniil, additional, Vorontsov, Alexander, additional, Ambrosimov, Alexander, additional, Grigoriev, Andrei, additional, Shishkina, Lyudmila, additional, Pronin, Eugeny, additional, Azizyan, Vilen, additional, Godkov, Ivan, additional, Belysheva, Elena, additional, Demidova, Tatiana, additional, and Poteshkin, Yury, additional

Published
2019
Full Text
View/download PDF

9. Lanreotide Autogel 120 mg at extended dosing intervals in patients with acromegaly biochemically controlled with octreotide LAR : the LEAD study

Author

Neggers, Sebastian J C M M, Pronin, Vyacheslav, Balcere, Inga, Lee, Moon-Kyu, Rozhinskaya, Liudmila, Bronstein, Marcello D, Gadelha, Mônica R, Maisonobe, Pascal, Sert, Caroline, van der Lely, Aart Jan, Neggers, Sebastian J C M M, Pronin, Vyacheslav, Balcere, Inga, Lee, Moon-Kyu, Rozhinskaya, Liudmila, Bronstein, Marcello D, Gadelha, Mônica R, Maisonobe, Pascal, Sert, Caroline, and van der Lely, Aart Jan

Abstract

OBJECTIVE: To evaluate extended dosing intervals (EDIs) with lanreotide Autogel 120 mg in patients with acromegaly previously biochemically controlled with octreotide LAR 10 or 20 mg. DESIGN AND METHODS: Patients with acromegaly had received octreotide LAR 10 or 20 mg/4 weeks for ≥ 6 months and had normal IGF1 levels. Lanreotide Autogel 120 mg was administered every 6 weeks for 24 weeks (phase 1); depending on week-24 IGF1 levels, treatment was then administered every 4, 6 or 8 weeks for a further 24 weeks (phase 2). Hormone levels, patient-reported outcomes and adverse events were assessed. PRIMARY ENDPOINT: proportion of patients on 6- or 8-week EDIs with normal IGF1 levels at week 48 (study end). RESULTS: 107/124 patients completed the study (15 withdrew from phase 1 and two from phase 2). Of 124 patients enrolled, 77.4% were allocated to 6- or 8-week EDIs in phase 2 and 75.8% (95% CI: 68.3-83.3) had normal IGF1 levels at week 48 with the EDI (primary analysis). A total of 88.7% (83.1-94.3) had normal IGF1 levels after 24 weeks with 6-weekly dosing. GH levels were ≤ 2.5 μg/l in > 90% of patients after 24 and 48 weeks. Patient preferences for lanreotide Autogel 120 mg every 4, 6 or 8 weeks over octreotide LAR every 4 weeks were high. CONCLUSIONS: Patients with acromegaly achieving biochemical control with octreotide LAR 10 or 20 mg/4 weeks are possible candidates for lanreotide Autogel 120 mg EDIs. EDIs are effective and well received among such patients., Bertil Ekman, vid avdelningen för kardiovaskulär medicin samt endokrinmedicinska kliniken, tillhör "LEAD Study Group".

Published
2015
Full Text
View/download PDF

10. Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients.

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Unité d'endocrinologie pédiatrique, Rostomyan, Liliya, Daly, Adrian F, Petrossians, Patrick, Nachev, Emil, Lila, Anurag R, Lecoq, Anne-Lise, Lecumberri, Beatriz, Trivellin, Giampaolo, Salvatori, Roberto, Moraitis, Andreas G, Holdaway, Ian, Kranenburg-van Klaveren, Dianne J, Chiara Zatelli, Maria, Palacios, Nuria, Nozieres, Cecile, Zacharin, Margaret, Ebeling, Tapani, Ojaniemi, Marja, Rozhinskaya, Liudmila, Verrua, Elisa, Jaffrain-Rea, Marie-Lise, Filipponi, Silvia, Gusakova, Daria, Pronin, Vyacheslav, Bertherat, Jerome, Belaya, Zhanna, Ilovayskaya, Irena, Sahnoun-Fathallah, Mona, Sievers, Caroline, Stalla, Gunter K, Castermans, Emilie, Caberg, Jean-Hubert, Sorkina, Ekaterina, Auriemma, Renata Simona, Mittal, Sachin, Kareva, Maria, Lysy, Philippe, Emy, Philippe, De Menis, Ernesto, Choong, Catherine S, Mantovani, Giovanna, Bours, Vincent, De Herder, Wouter, Brue, Thierry, Barlier, Anne, Neggers, Sebastian J C M M, Zacharieva, Sabina, Chanson, Philippe, Shah, Nalini Samir, Stratakis, Constantine A, Naves, Luciana A, Beckers, Albert, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Unité d'endocrinologie pédiatrique, Rostomyan, Liliya, Daly, Adrian F, Petrossians, Patrick, Nachev, Emil, Lila, Anurag R, Lecoq, Anne-Lise, Lecumberri, Beatriz, Trivellin, Giampaolo, Salvatori, Roberto, Moraitis, Andreas G, Holdaway, Ian, Kranenburg-van Klaveren, Dianne J, Chiara Zatelli, Maria, Palacios, Nuria, Nozieres, Cecile, Zacharin, Margaret, Ebeling, Tapani, Ojaniemi, Marja, Rozhinskaya, Liudmila, Verrua, Elisa, Jaffrain-Rea, Marie-Lise, Filipponi, Silvia, Gusakova, Daria, Pronin, Vyacheslav, Bertherat, Jerome, Belaya, Zhanna, Ilovayskaya, Irena, Sahnoun-Fathallah, Mona, Sievers, Caroline, Stalla, Gunter K, Castermans, Emilie, Caberg, Jean-Hubert, Sorkina, Ekaterina, Auriemma, Renata Simona, Mittal, Sachin, Kareva, Maria, Lysy, Philippe, Emy, Philippe, De Menis, Ernesto, Choong, Catherine S, Mantovani, Giovanna, Bours, Vincent, De Herder, Wouter, Brue, Thierry, Barlier, Anne, Neggers, Sebastian J C M M, Zacharieva, Sabina, Chanson, Philippe, Shah, Nalini Samir, Stratakis, Constantine A, Naves, Luciana A, and Beckers, Albert

Abstract

Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients. We included 208 patients (163 males; 78.4%) with growth hormone excess and a current/previous abnormal growth velocity for age or final height >2 s.d. above country normal means. The median onset of rapid growth was 13 years and occurred significantly earlier in females than in males; pituitary adenomas were diagnosed earlier in females than males (15.8 vs 21.5 years respectively). Adenomas were ≥10 mm (i.e., macroadenomas) in 84%, of which extrasellar extension occurred in 77% and invasion in 54%. GH/IGF1 control was achieved in 39% during long-term follow-up. Final height was greater in younger onset patients, with larger tumors and higher GH levels. Later disease control was associated with a greater difference from mid-parental height (r=0.23, P=0.02). AIP mutations occurred in 29%; microduplication at Xq26.3 - X-linked acrogigantism (X-LAG) - occurred in two familial isolated pituitary adenoma kindreds and in ten sporadic patients. Tumor size was not different in X-LAG, AIP mutated and genetically negative patient groups. AIP-mutated and X-LAG patients were significantly younger at onset and diagnosis, but disease control was worse in genetically negative cases. Pituitary gigantism patients are characterized by male predominance and large tumors that are difficult to control. Treatment delay increases final height and symptom burden. AIP mutations and X-LAG explain many cases, but no genetic etiology is seen in >50% of cases.

Published
2015

11. Lanreotide Autogel 120 mg at extended dosing intervals in patients with acromegaly biochemically controlled with octreotide LAR: the LEAD study

Author

Neggers, Sebastian JCMM, primary, Pronin, Vyacheslav, additional, Balcere, Inga, additional, Lee, Moon-Kyu, additional, Rozhinskaya, Liudmila, additional, Bronstein, Marcello D, additional, Gadelha, Mônica R, additional, Maisonobe, Pascal, additional, Sert, Caroline, additional, van der Lely, Aart Jan, additional, and _, _, additional

Published
2015
Full Text
View/download PDF

12. Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients

Author

Rostomyan, Liliya, primary, Daly, Adrian F, additional, Petrossians, Patrick, additional, Nachev, Emil, additional, Lila, Anurag R, additional, Lecoq, Anne-Lise, additional, Lecumberri, Beatriz, additional, Trivellin, Giampaolo, additional, Salvatori, Roberto, additional, Moraitis, Andreas G, additional, Holdaway, Ian, additional, Kranenburg - van Klaveren, Dianne J, additional, Chiara Zatelli, Maria, additional, Palacios, Nuria, additional, Nozieres, Cecile, additional, Zacharin, Margaret, additional, Ebeling, Tapani, additional, Ojaniemi, Marja, additional, Rozhinskaya, Liudmila, additional, Verrua, Elisa, additional, Jaffrain-Rea, Marie-Lise, additional, Filipponi, Silvia, additional, Gusakova, Daria, additional, Pronin, Vyacheslav, additional, Bertherat, Jerome, additional, Belaya, Zhanna, additional, Ilovayskaya, Irena, additional, Sahnoun-Fathallah, Mona, additional, Sievers, Caroline, additional, Stalla, Gunter K, additional, Castermans, Emilie, additional, Caberg, Jean-Hubert, additional, Sorkina, Ekaterina, additional, Auriemma, Renata Simona, additional, Mittal, Sachin, additional, Kareva, Maria, additional, Lysy, Philippe A, additional, Emy, Philippe, additional, De Menis, Ernesto, additional, Choong, Catherine S, additional, Mantovani, Giovanna, additional, Bours, Vincent, additional, De Herder, Wouter, additional, Brue, Thierry, additional, Barlier, Anne, additional, Neggers, Sebastian J C M M, additional, Zacharieva, Sabina, additional, Chanson, Philippe, additional, Shah, Nalini Samir, additional, Stratakis, Constantine A, additional, Naves, Luciana A, additional, and Beckers, Albert, additional

Published
2015
Full Text
View/download PDF

13. Pasireotide long-acting release maintains biochemical control in patients with acromegaly: results from the extension of randomised, Phase III, PAOLA study

Author

Colao, Anna Maria, primary, Bronstein, Marcello D, additional, Brue, Thierry, additional, Coculescu, Mihail, additional, Marinis, Laura De, additional, Fleseriu, Maria, additional, Guitelman, Mirtha A, additional, Pronin, Vyacheslav, additional, Raverot, Gerald, additional, Shimon, Ilan, additional, Fleck, Juergen, additional, Kandra, Albert, additional, Pedroncelli, Alberto M, additional, and Gadelha, Monica R, additional

Published
2015
Full Text
View/download PDF

15. Pasireotide LAR demonstrates superior efficacy versus octreotide LAR and lanreotide ATG in patients with inadequately controlled acromegaly: results from a phase III, multicentre, randomized study (PAOLA)

Author

Gadelha, Monica, primary, Bronstein, Marcello, additional, Brue, Thierry, additional, Coculescu, Mihail, additional, Fleseriu, Maria, additional, Guitelman, Mirtha, additional, Pronin, Vyacheslav, additional, Raverot, Gerald, additional, Shimon, Ilan, additional, Lievre, Kayo Kodama, additional, Fleck, Juergen, additional, Aout, Mounir, additional, Pedroncelli, Alberto, additional, and Colao, Annamaria, additional

Published
2014
Full Text
View/download PDF

17. Characteristics of patients with pituitary gigantism: results of an international study

Author

Rostomyan, Liliya, primary, Daly, Adrian F., additional, Tichomirowa, Maria, additional, Naves, Luciana A., additional, Shah, Nalini, additional, Chanson, Philippe, additional, Zacharieva, Sabina, additional, Stratskis, Constantine A, additional, Neggers, Sebastian, additional, Holdaway, Ian, additional, Stalla, Gunter K., additional, Pronin, Vyacheslav, additional, Maiter, Dominique, additional, Bertherat, Jerome, additional, Colao, Annamaria, additional, Ilovaiskaya, Irena, additional, Ferone, Diego, additional, Zacharin, Margaret, additional, Salvatori, Roberto, additional, and Beckers, Albert, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results