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Encephalocele is a rare congenital malformation of the central nervous system. The prevalence is estimated to be about 1 in 5,000-40,000 live births. It can affect various anatomical locations such as the occipital, frontal, temporal, and parietal regions. The fourth and fifth weeks of embryonic development are critical for the development of the head and neck. When there is a failure in the separation of the superficial ectoderm from the neuroectoderm, neural tube defects occur, from which encephaloceles may arise. Genetically it can be explained by the dysembryological theory, which involves certain mutated genes that interfere with important cellular mechanisms in early neuronal development. Currently, thanks to prenatal screening tools such as ultrasound, it is possible to identify them from intrauterine life. It is extremely important to make an early diagnosis to establish protocols and provide individualized treatment, involving a multidisciplinary team will be involved. Even though some cases are usually compatible with life, the expected prognosis of the anatomical site involved as well as timely surgical management. One of the most important sequelae is intellectual deficit. [ABSTRACT FROM AUTHOR]

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of GeSec: Revista de Gestao e Secretariado is the property of Sindicato das Secretarias e Secretarios do Estado de Sao Paulo (SINSESP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Climate change is one of the most important drivers of ecosystem change, the global‐scale impacts of which will intensify over the next 2 decades. Estimating the timing of unprecedented changes is not only challenging but is of great importance for the development of ecosystem conservation guidelines. Time of emergence (ToE) (point at which climate change can be differentiated from a previous climate), a widely applied concept in climatology studies, provides a robust but unexplored approach for assessing the risk of ecosystem collapse, as described by the C criterion of the International Union for Conservation of Nature's Red List of Ecosystems (RLE). We identified 3 main theoretical considerations of ToE for RLE assessment (degree of stability, multifactorial instead of one‐dimensional analyses, and hallmarks of ecosystem collapse) and 4 sources of uncertainty when applying ToE methodology (intermodel spread, historical reference period, consensus among variables, and consideration of different scenarios), which aims to avoid misuse and errors while promoting a proper application of the framework by scientists and practitioners. The incorporation of ToE for the RLE assessments adds important information for conservation priority setting that allows prediction of changes within and beyond the time frames proposed by the RLE. [ABSTRACT FROM AUTHOR]

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: shoulder plain is a common cause of complain, however a precise diagnosis is hard to achieve. This is why finding factors associated to a good prognosis could help to improve our clinical practice. Objective: to identify demographic and clinical characteristics from the initial assessment associated with substantial clinical benefit (SCB) in patients with shoulder pain one month after treatment or at patient's discharge. Material and methods: this was a secondary analysis of a prospective cohort of patients with shoulder pain. Demographic and clinical (self-reported scales) factors associated with SCB at discharge or four weeks after the initial assessment, were analyzed. SCB was defined as a score ≥ +5 on a Global Rating of Change. A logistic regression model was made in order to identify predictors of SCB. The area under the curve ROC was used to assess the performance of the model with its independent variables. Results: 101 patients of 138 were analyzed. The median age was 55 (RIQ 37-61) years old, there were 55 (54.5%) women in the sample. The variables independently associated to SCB were fracture as a reason for admission [adjusted OR 11.8 (95% CI 1.4-101.8); p = 0.024], and durations of shoulder symptoms shorter than seven months [adjusted OR 4.63 (95% CI 1.9-11.1); p = 0.001]. Conclusion: the diagnosis of fracture and durations of shoulder symptoms shorter than seven months were independently associated with a SCB after one month of treatment or at the patient's discharge. [ABSTRACT FROM AUTHOR]

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To validate an artificial intelligence model that can predict the mortality prognosis of hospitalized patients with sepsis. MATERIALS AND METHODS: An ambispective observational cohort study, which included electronic records of adult patients from the Central Hospital of the State of Chihuahua, Mexico, from July 2018 to March 2020 and January 2021 to January 2022. Three models were analyzed: neural networks, support vector machine and random forests. For model validation, the sample was divided into 80% for training and 20% for testing. For the last group (20%), a 10-fold cross-validation was implemented to calculate sensitivity, specificity, positive predictive value, and negative predictive value. RESULTS: A total of 353 files were analyzed, of which only 218 were chosen. The best model was the neural networks; however, its area under the curve (AUC) score barely reached 0.80, the random forests algorithm (AUC 0.667) and the support vec- tor machine algorithm (AUC 0.641) were below this value. Of the 3 models, only the cross-validation with the neural networks was done, of 20% of the test data, 10 validations were implemented. The AUC scores obtained in each fold ranged from 0.771 to 0.830. CONCLUSIONS: The model is good, even working with few data. It is intended to collect a larger sample to retrain and validate the model with more data and improve learning and performance and finally be applicable to patients. [ABSTRACT FROM AUTHOR]

One of the complications during an acute coronary syndrome event is the presence of arrhythmias. Among them, those of the supraventricular type, especially atrial fibrillation, carry a poor prognosis both in the short and long term, being the cause of situations such as cerebrovascular event, ventricular arrhythmias, and increased mortality. The arrhythmia tends to appear in a certain population group with particular risk factors during the index event in approximately 10% of cases. Appropriate treatment at the time of its onset, thanks to the use of drugs that modulate heart rate, rhythm, and anticoagulant management in the most vulnerable groups, will lead to a less bleak outcome for these patients. [ABSTRACT FROM AUTHOR]

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de la Facultad de Medicina Humana is the property of Instituto de Investigaciones en Ciencias Biomedicas de la Universidad Ricardo Palma and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

La generación y aplicación de modelos probabilísticos son requeridas para tomar decisiones asertivas basadas en datos asociados con los tiempos de acceso y servicio de usuarios en diversas organizaciones. El objetivo consistió en analizar el sistema de líneas de espera de la biblioteca central de una universidad, mediante parámetros destinados a medir su desempeño. La metodología incluyó técnicas cuantitativas centradas en un diseño de tipo transversal. La información fue recolectada con una rejilla de observación y el conteo del número de estudiantes que entraban a la biblioteca en lapsos de 10 minutos para realizar actividades de consulta. Con los datos se ajustaron modelos de probabilidad para describir la operación del sistema. Los resultados evidenciaron que éste operaba establemente, con tiempos de espera cortos y tiempos de servicio pertinentes. Se pudo concluir que el sistema de biblioteca analizado logra un porcentaje alto (89.06%) de uso por parte del estudiantado en el horario observado.

La investigación tiene como objetivo la elaboración de un modelo agrometeorológico de pronóstico del rendimiento agrícola azucarero. Se tomaron los rendimientos por cepas y totales, área de cada cepa y total, y edad de la plantación de 13 Unidades Empresariales de Base de las provincias Cienfuegos, Sancti Spíritus y Ciego de Ávila en el período 1980–2015; así como, registros mensuales de precipitación, temperatura media y evapotranspiración de siete estaciones meteorológicas. Se calculó el Índice Potencial Productivo según la fase fenológica en la que se encuentre para comprobar su grado de efectividad. Para el procesamiento estadístico se utilizó el tabulador Excel, STATISTICA versión 8.0.5 y el módulo matemático SciPy. La efectividad de las estimaciones de rendimiento agrícola obtenidas con el modelo presentado para las zafras 2011 – 2015, se comparó usando el coeficiente de determinación R2, analizando la relación establecida entre las variables regresoras y el predictando. El modelo de regresión lineal múltiple permite realizar pronósticos de rendimiento agrícola con precisión y ajuste, en dependencia de los escenarios comerciales concretos de la producción cañera del país. La provincia Ciego de Ávila revela, de las tres en estudio, el mayor grado de efectividad en la estimación del rendimiento agrícola de la caña de azúcar.

The calcium-activated chloride channel (CLCA2) performs a vital function in the intricate process of tumorigenesis. Using a bioinformatics analysis system, we conducted a pan-cancer investigation on CLCA2 to explore its association with tumor prognosis and its involvement in immunology. In order to achieve this objective, we examined the prognostic significance and expression level of CLCA2 in multiple cancer types using the TIMER and Sangerbox databases. The analysis of protein interaction networks revealed proteins linked to CLCA2. To investigate the potential biological functions and enrichment pathways of CLCA2 in cancer, the SangerBox and GSCA databases were utilized. Furthermore, the expression of CLCA2 in different cancer subtypes was evaluated during the analysis. Various functional conditions of cancer cells were then compared with CLCA2 in the CancerSEA database. Using online tools like TISIDB and Assistant for Clinical Bioinformatics, the investigation explored the link between CLCA2 and immune subtypes. Additionally, it assessed immune cell infiltration as part of the analysis. In addition, the application of GDSA was employed to investigate the predictive significance of CLCA2 in relation to drug sensitivity. The research outcomes uncovered abnormal expression patterns of CLCA2 in diverse tumor categories, with its expression level demonstrating a correlation with distinct subtypes of tumors. Strong associations have been observed between enhanced patient survival rates and CLCA2 in specific tumor types. There is a noteworthy connection observed among diverse tumor types, immune cell infiltration, immune subtypes, and CLCA2. The enrichment analysis of KEGG indicates that there may exist a connection between the expression of CLCA2 and renin secretion, pancreatic secretion, as well as other pathways in pan-cancer. CLCA2 appears to primarily activate pathways such as EMT (epithelial-mesenchymal transition), RAS/MAPK, RTK, apoptosis, TSC/mTOR, and PI3K/ AKT in pan-cancer. On the other hand, it seems to inhibit pathways like cell cycle, DNA damage, hormone AR, and hormone ER. Through single-cell functional analysis, it has been confirmed that CLCA2 is associated with diverse cellular functional states, encompassing DNA repair, EMT, hypoxia, invasion, metastasis, and quiescence. Furthermore, a substantial correlation has been observed between the expression of CLCA2 and drug sensitivity towards bosutinib, tipifarnib-P1, as well as other therapeutic agents. This research affirms that various cancer types express CLCA2 and its involvement in tumor advancement and immune penetration. CLCA2 possesses the capability to function as a noteworthy biomarker and target for therapeutic intervention in diverse cancer forms. [ABSTRACT FROM AUTHOR]

Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of World Water Policy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To determine the prevalence of these symptoms in the Mexican population treated at the General Hospital no. 46 and to examine whether anosmia is related to a mild form of the disease. MATERIALS AND METHODS: A descriptive cross-sectional study was carried out, extracting information from patients treated at the General Hospital no. 46 with a positive test for SARS-CoV-2, from June 2020 to September 2021. RESULTS: The sample included 8694 patients with a mean age of 49 years; 52.8% were men; 28.4% were classified as severe patients, with a predominance of males (p = 0.008). A prevalence of 10.6% of anosmia and 10.8% of dysgeusia was found. The relationship between the absence of anosmia and death as the cause of discharge was analyzed, considering sex a covariate. The results indicated that, in the case of men, the absence of anosmia was associated with a higher probability of death as a cause of hospital discharge. CONCLUSIONS: This inverse association between anosmia and mortality could have important implications in the classification and management of patients. Therefore, it is essential to continue investigating this relationship through more multicenter studies. [ABSTRACT FROM AUTHOR]

BACKGROUND: Primary cutaneous CD8-positive acral T-cell lymphoma is a rare primary cutaneous T-cell lymphoma, with less than 50 published cases. This entity can be confused with more frequent diseases, such as pseudolymphomas, B lymphomas and aggressive epidermotropic CD8 lymphomas. Unlike the latter, acral CD8+ lymphoma has an excellent prognosis. Making the correct diagnosis is essential in order not to overtreat the patient, avoid side effects of the established treatments and avoid patient anxiety. CLINICAL CASE: A 62-year-old male patient with a tumor lesion on the skin of the left ear, with clinical, histological and immunohistochemical characteristics of CD8-positive acral T-cell lymphoma, with a good response to radiotherapy and interferon but with 4 relapses over 12 years of treatment. CONCLUSIONS: CD8-positive primary cutaneous T-cell lymphoma is a rare entity with a good prognosis, which can be confused with numerous inflammatory and granulomatous illnesses. The few published cases generally have an excellent response to treatment; however, follow-up is short. We report a case with a typical presentation, with a long follow-up time and a special behavior due to multiple recurrences. [ABSTRACT FROM AUTHOR]

Purpose: To identify patterns of chest computed tomography (CT) imaging that associate with coronavirus disease 2019 (COVID-19) lethality in palliative care patients. Methods: Data were collected from 44 patients with COVID-19 confirmed by reverse transcription-polymerase chain reaction. The total CT score comprised the sum of lung involvement (5 lobes, scores 1-4 for each lobe). Twenty-two patients who recovered from COVID-19 and 22 patients who died were enrolled. The clinical and imaging characteristics between the deceased patients and survivors were compared. Results: Diffuse lesions were present in 20 (91%) patients who succumbed but only in 12 (55%) patients who recovered (p < 0.006). The presence of pleural effusion on the initial CT chest was also more frequently found in deceased than in surviving patients (55 vs. 9%, p = 0.001). In the death group, the total CT score was higher than that of the recovery group (12.4 ± 2.54 vs. 5.08 ± 3.37, p < 0.001). The optimal cut-off points to predict mortality was 9.5, with sensitivity of 90%, specificity of 91.7%, and AUC of 0.921. Conclusion: A high CT score, the diffuse distribution of lung lesions and the pleural effusion are indicative of short-term mortality in oncology patients in palliative care suffering COVID-19. [ABSTRACT FROM AUTHOR]

Copyright of Gaceta Médica de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Neutrosophic Computing & Machine Learning is the property of Multimedia Larga and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

En los tumores sólidos la hipereosinofilia es un fenómeno raro y se asocia principalmente con carcinomas secretores de mucina. Los tumores tiroideos asociados a neutrofilia y/o eosinofilia se han descrito exclusivamente en pacientes con cáncer anaplásico de tiroides. La eosinofilia asociada con cáncer papilar de tiroides es extremadamente rara y se encuentran muy pocos casos descriptos actualmente. Se ha sugerido que tres citocinas, a saber, la interleucina-3 (IL-3), la interleucina-5 (IL-5) y el factor estimulante de colonias de granulocitos y macrófagos (GM-CSF), pueden actuar como un péptido eosinofílico potencial. Hasta el momento solo se han reportado tres pacientes con cáncer diferenciado de tiroides asociados a eosinofilia, dos de tipo papilar y uno de tipo medular. Paciente de 48 años consultó en el año 2022 por adenopatías cervicales bilaterales de 3 años de evolución asociado a síndrome consuntivo e hipereosinofilia. Se solicitó PET CT que evidenció foco hipermetabólico en lóbulo tiroideo derecho y metástasis ganglionares, pulmonares, óseas y hepáticas; ecografía tiroidea que evidencia en lóbulo derecho nódulo de alta sospecha de malignidad y conglomerado de adenopatías con lavado de aguja positivo para tiroglobulina. Evaluada la hipereosinofilia con valores iniciales de leucocitosis de GB 30310/mm3 (10608/mm3 de eosinófilos) hasta valores máximos de GB 77090/mm3 (eosinófilos 20814/mm3) se interpretó como síndrome paraneoplásico y se inició corticoterapia en dosis inmunosupresoras sin respuesta. Nuestras observaciones presentadas en este artículo están en línea con la mayoría de los estudios que reflejan que la hipereosinofilia paraneoplásica se caracteriza por una enfermedad más avanzada y un mal pronóstico.

Introducción. En los pacientes con falla cardíaca, el sodio urinario se ha propuesto como marcador de gravedad y resistencia a los diuréticos, pero los resultados de los estudios reportados son heterogéneos. Objetivo. Evaluar el sodio en orina ocasional como factor pronóstico de mortalidad en pacientes con falla cardiaca descompensada. Materiales y métodos. Se realizó un análisis anidado de casos y controles de una cohorte prospectiva de falla cardíaca descompensada. El desenlace primario fue mortalidad a los 180 días. Se hizo un análisis bivariado para evaluar las variables que se asocian con la mortalidad. Se analizaron las diferencias de las variables clínicas entre los grupos con sodio urinario mayor o menor de 70 mEq/L. Resultados. Se incluyeron 79 pacientes de los cuales 15 fallecieron a los 180 días. La edad promedio fue de 68,9 años (DE: ±13,8), 30 eran mujeres (38 %). Quince pacientes (18,9 %) tuvieron un sodio en orina inferior a 70 mEq/L. En el análisis bivariado se encontró una asociación significativa de la mortalidad con las hospitalizaciones, la presión arterial sistólica inferior a 90 mm Hg, el uso de inotrópicos y el sodio urinario inferior a 70 mEq/L. Los pacientes con sodio urinario bajo habían estado hospitalizados con mayor frecuencia en el último año, tenían menores valores de sodio sérico y presión arterial al ingreso. Conclusión. Los pacientes con sodio urinario inferior a 70 mEq/L tienen características de mayor gravedad. En el análisis bivariado, el sodio urinario se asoció con mortalidad a los 180 días.

Copyright of Arquivos de Ciências da Saúde da UNIPAR is the property of Associacao Paranaense de Ensino e Cultura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and Objective: From the onset of COVID-19 pandemic, the presence of previous cardiopathy was thought to be related with a worse prognosis of the disease. We aimed to analyse that theoretical adverse impact in a large cohort of patients. Method: We selected 1065 patients admitted for SARS-CoV-2 pneumonia between March and June 2020, divided in three groups according to (1) absence of cardiopathy, (2) presence of valvular heart disease or ischemic heart disease, or (3) presence of heart failure. We analysed the differences between groups regarding the need for admission in intensive care unit for mechanical ventilation or mortality during admission, or mortality during admission or in the next 6 months. Results: The factors that were associated with a worse prognosis both in acute phase and in the next 6 months were age, male gender, obesity and oncologic disease. The presence of previous cardiopathy did not have an adverse prognostic impact neither initially nor in the short term, in our study. Conclusions: We did not obtain significative association of the presence of cardiopathy with a worse medical evolution, neither in acute phase nor in the short term, of patients admitted for SARS-CoV-2 pneumonia. [ABSTRACT FROM AUTHOR]

Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Tourism has gained vital importance in recent times as it is one of the economic activities that brings the greatest benefits to a country, both in the social, economic and environmental spheres. Consequently, demand forecasting models in the sector are adequate tools that support decision-making. In this sense, several authors have made important contributions in the field of science that help improve tourism management. This leads to the objective of analyzing current trends in tourism forecasting models using the R bibliometrix tool, covering 254 research articles published between 2017 and 2021. The main results show that the models for forecasting tourism demand they are constantly evolving and there is no single model that works well for all situations. It can also be seen that due to the COVID-19 pandemic, the forecast models for that year were unusable; however, it was the year with the most publications. Similarly, this research allowed to identify the main countries, scientific journals and authors who address the study of tourism demand. [ABSTRACT FROM AUTHOR]

Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To determine the prevalence of these symptoms in the Mexican population treated at the General Hospital no. 46 and to examine whether anosmia is related to a mild form of the disease. MATERIALS AND METHODS: A descriptive cross-sectional study was carried out, extracting information from patients treated at the General Hospital no. 46 with a positive test for SARS-CoV-2, from June 2020 to September 2021. RESULTS: The sample included 8694 patients with a mean age of 49 years; 52.8% were men; 28.4% were classified as severe patients, with a predominance of males (p = 0.008). A prevalence of 10.6% of anosmia and 10.8% of dysgeusia was found. The relationship between the absence of anosmia and death as the cause of discharge was analyzed, considering sex a covariate. The results indicated that, in the case of men, the absence of anosmia was associated with a higher probability of death as a cause of hospital discharge. CONCLUSIONS: This inverse association between anosmia and mortality could have important implications in the classification and management of patients. Therefore, it is essential to continue investigating this relationship through more multicenter studies. [ABSTRACT FROM AUTHOR]

This research employed empirical methods that relate rainfall to debris flow movements, which consist of series of accumulated rainfall that trigger these movements. Additionally, statistical thresholds were established using power law in linear coordinates (logarithmic relationship) and non-parametric statistics. Consequently, critical thresholds for triggering accumulated rainfall (LA) and antecedent accumulated rainfall (LAA) were established. Furthermore, this empirical-statistical model incorporates the local conditions of the study area, including certain physical parameters and soil moisture conditions, and combines them with the hazard conditions specific to the region for which they were defined. [ABSTRACT FROM AUTHOR]

Copyright of Acta Neurológica Colombiana is the property of Colombian Association of Neurology / Asociacion Colombiana de Neurologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Fundamento: en las últimas seis décadas han existido avances significativos en la supervivencia de los pacientes y en los resultados funcionales tras una cirugía de reemplazo de válvulas cardíacas. Objetivo: identificar factores predictivos de supervivencia relacionados con el síndrome de bajo gasto cardíaco, en pacientes con cirugía cardíaca valvular, atendidos en el Centro de Cirugía Cardiovascular y Cardiología, Hospital Provincial Clínico Quirúrgico Docente Saturnino Lora Torres, en Santiago de Cuba, entre enero 2019 y diciembre 2021. Métodos: se realizó un estudio analítico de casos y controles en pacientes que tuvieron síndrome de bajo gasto cardíaco en el período posoperatorio, luego de recibir cirugía valvular cardíaca en el centro y período de tiempo antes declarados. Se trabajó con una muestra de 168 pacientes, divididos en dos grupos: uno con 56 casos de síndrome de bajo gasto cardíaco y 112 controles, que no presentaron esta entidad. Resultados: 34,5 % de los pacientes tenían edad ≥ 65 años; el antecedente de diabetes mellitus y de fibrilación auricular mostraron asociación con la aparición de bajo gasto cardíaco. La cirugía de emergencia (en 45,2 % de los pacientes); sangramiento, tiempo de circulación extracorpórea, función sistólica del ventrículo izquierdo y excursión sistólica del plano anular tricúspideo alterados, además de la presencia de hipertensión pulmonar, evidenciaron asociación. Conclusiones: la edad > 65 años, disfunción de ambos ventrículos deprimida, el antecedente de fibrilación auricular y el tiempo de circulación extracorpórea mayor de 90 minutos, son capaces de predecir la aparición de bajo gasto cardíaco y la supervivencia.

Introducción: La predicción de mortalidad en pacientes con enfermedad renal crónica, mediante escalas o índices pronósticos presenta limitaciones reales. Objetivo: Diseñar una escala predictiva de mortalidad en pacientes con enfermedad renal crónica. Métodos: Se realizó un estudio observacional, analítico, longitudinal prospectivo en 169 pacientes con enfermedad renal crónica desde el 1 de enero de 2022 al 31 de diciembre de 2022. La investigación se desarrolló en 2 etapas: Durante los primeros 6 meses del año se analizaron las variables de estudio para el diseño de la escala predictiva. En los próximos 6 meses, los pacientes fueron seguidos para identificar la ocurrencia o no de la variable dependiente mortalidad. Se determinó la capacidad discriminatoria de la escala predictiva y se evaluaron curvas de supervivencia. Resultados: Las variables que conformaron la escala predictiva fueron edad > 65 años, enfermedad cardiovascular, albúmina < 35 g/L, dislipidemia, hemoglobina < 10 g/L y ácido úrico > 390 mmol/L. El poder discriminatorio para predecir mortalidad fue bueno, índice C: 0,856 (IC 95 %: 0,783-0,929; p< 0,001). Los pacientes con valores menores a 4 puntos presentaron media de supervivencia de 149,438 ± 7,296 días. En cambio, los que tenían valores superiores presentaron media de supervivencia de 93,128 ± 8,545 días. Conclusiones: La escala predictiva contribuyó a la estratificación del riesgo de mortalidad de los pacientes. Las variables incluidas son de fácil determinación e interpretación por lo que es un modelo útil en la toma de decisiones médicas en el ámbito clínico actual.

Esta investigación utilizó métodos empíricos que relacionan la lluvia con los movimientos de flujo de detritos; los cuales, consisten en series de lluvia acumulada que detonan estos movimientos. Además, se procedió a establecer los umbrales estadísticos mediante la ley de la potencia en coordenadas lineales (relación logarítmica) y la estadística no paramétrica. En consecuencia, se establecieron los umbrales críticos de lluvia acumulada detonante (LA) y lluvia acumulada antecedente (LAA). Asimismo, a este modelo empírico-estadístico, se añade las condiciones locales de la zona de estudio; es decir, algunos parámetros físicos y la condición húmeda del suelo, así como combinarlos con las condiciones de amenaza de la región para la cual fueron definidos.

Abstract Aims In heart failure patients renal dysfunction represents impaired tissue perfusion. We investigated the association of customarily used renal function parameters with short-term prognosis in patients admitted with acute decompensated heart failure in class III or IV of New York Heart Association. Material and Methods Univariate Cox proportional hazard model was used to assess the relationship between variables and outcomes. Survival curves were designed using the Kaplan-Meier method. Results We followed 65 patients for a median of 13.7 (Q1-Q3 6.7-18.9) months. Variables associated with an increased risk for short-term rehospitalization were baseline urea (HR: 1.098, 95% CI: 1.022-1.179, P-value=0.01), admission urea (HR: 1.048, 95% CI: 1.013-1.084, P-value=0.006), baseline creatinine (HR: 1.111, 95% CI: 1.004-1.229, P-value=0.041), admission creatinine (HR: 1.047, 95% CI: 1.005-1.092, P-value=0.027) and admission glomerular filtration rate

Objetivos. Evaluar las comorbilidades asociadas a la mortalidad en pacientes adultos hospitalizados por COVID-19 19 de diferentes grupos de edad en hospitales de Lima y Callao. Materiales y métodos. En este estudio de cohorte retrospectiva analizamos datos de pacientes adultos hospitalizados por COVID-19 notificados al Sistema Nacional de Vigilancia Epidemiológica del Ministerio de Salud de Perú de marzo a octubre del 2020. Se estimaron riesgos relativos con intervalos de confianza al 95% mediante modelos de regresión de Poisson con varianza robusta para evaluar las comorbilidades asociadas a la mortalidad por grupos de edad: jóvenes (18-29 años), adultos (30-59 años) y mayores (≥60 años). Resultados. Se incluyeron 2366 jóvenes, 23781 adultos y 25356 adultos mayores en el análisis. Los adultos mayores presentaron la mortalidad más alta (63,7%) en comparación con adultos (27,1%) y jóvenes (8,5%). Independientemente del grupo de edad, la presencia de enfermedad neurológica, enfermedad renal, enfermedad hepática y cáncer se asoció a un mayor riesgo de mortalidad. Adicionalmente, la enfermedad cardiovascular es también un factor de riesgo en los jóvenes; la obesidad, la diabetes, la enfermedad cardiovascular, la enfermedad pulmonar crónica y la inmunodeficiencia en los adultos; y la obesidad y la enfermedad pulmonar crónica en los mayores. Conclusiones: Independientemente de los grupos de edad, los individuos con enfermedad neurológica crónica, enfermedad renal, enfermedad hepática y cáncer tendrían un alto riesgo de morir por la COVID-19.

We performed a retrospective analysis of the patients assessed at our memory unit for whom Alzheimer disease (AD) cerebrospinal fluid biomarker results were available. We selected patients diagnosed with mild cognitive impairment due to AD (National Institute on Aging-Alzheimer’s Association clinical criteria), confirmed neuropsychological deficit, a Global Deterioration Scale score of 3, and an abnormal profile of cerebrospinal fluid biomarkers. Of the 588 cases reviewed, 110 met the inclusion criteria. During follow-up, 50 cases (45.45%) progressed to dementia due to AD. Baseline levels of total and phosphorylated tau were higher in the group of patients that progressed to dementia than in those remaining with mild cognitive impairment. After adjusting for age, sex, history of hypertension, diabetes, and educational level, a 10% increase in total tau protein values was associated with a 7.60% increase in the risk of progression to dementia (hazard ratio: 2.22; 95% confidence interval, 1.28–3.84]; P = .004). Among patients with mild cognitive impairment due to AD and abnormal cerebrospinal fluid biomarker profiles, progressively higher concentrations of total or phosphorylated tau were associated with increased risk of progression to dementia. Resumen: Realizamos un análisis retrospectivo de los pacientes evaluados en nuestra unidad de memoria en los que se realizó determinación de biomarcadores licuorales de enfermedad de Alzheimer (EA). Se seleccionaron aquellos casos con diagnóstico de deterioro cognitivo leve debido a EA según criterios clínicos (criterios NIA-AA), déficit neuropsicológico comprobado, una puntuación igual a 3 en la escala GDS y un perfil alterado de biomarcadores en líquido cefalorraquídeo. De los 588 casos revisados, 110 cumplieron los criterios de inclusión. Durante el seguimiento, 50 de estos 110 casos (45,45%) progresaron a demencia por EA. Se observaron diferencias significativas en los niveles basales de tau total y tau fosforilada entre los casos que evolucionaron a demencia y los que permanecieron estables como deterioro cognitivo leve, siendo los niveles más altos en el grupo que progresó a demencia. Después del ajuste por edad, sexo, antecedentes de hipertensión, diabetes y nivel educativo, un aumento del 10% en los valores de proteína tau total se asoció con un aumento del 7,60% en el riesgo de progresión a demencia (HR = 2,22, IC 95% [1,28, 3.84], P = .004). En pacientes con deterioro cognitivo leve debido a EA un perfil alterado de biomarcadores licuorales, concentraciones progresivamente mayores de tau-t y tau-p se asocian a un mayor riesgo de conversión a demencia.

Introduction: Glycaemic variability (GV) refers to variations in blood glucose levels, and may affect stroke outcomes. This study aims to assess the effect of GV on acute ischaemic stroke progression. Methods: We performed an exploratory analysis of the multicentre, prospective, observational GLIAS-II study. Capillary glucose levels were measured every 4 hours during the first 48 hours after stroke, and GV was defined as the standard deviation of the mean glucose values. The primary outcomes were mortality and death or dependency at 3 months. Secondary outcomes were in-hospital complications, stroke recurrence, and the impact of the route of insulin administration on GV. Results: A total of 213 patients were included. Higher GV values were observed in patients who died (n = 16; 7.8%; 30.9 mg/dL vs 23.3 mg/dL; p = 0.05). In a logistic regression analysis adjusted for age and comorbidity, both GV (OR = 1.03; 95% CI, 1.003-1.06; p = 0.03) and stroke severity (OR = 1.12; 95% CI, 1.04-1.2; p = 0.004) were independently associated with mortality at 3 months. No association was found between GV and the other outcomes. Patients receiving subcutaneous insulin showed higher GV than those treated with intravenous insulin (38.95 mg/dL vs 21.34 mg/dL; p

Introducción: la criptococosis meníngea es una infección oportunista universal que presenta factores pronósticos variables, especialmente en pacientes inmunosuprimidos. Objetivo: identificar variables clínicas y paraclínicas asociadas con el desenlace, al final de la hospitalización, en pacientes con criptococosis meníngea atendidos en un hospital de tercer nivel en Bogotá, Colombia. Materiales y métodos: estudio observacional descriptivo. La información se obtuvo por medio de registros de historias clínicas de pacientes con diagnóstico confirmado de criptococosis meníngea durante el periodo 2016-2021. Resultados: se analizaron 54 casos, el 85,2?% de ellos de sexo masculino, con una mediana de edad de 38 años. El síntoma principal fue cefalea (74,1?%), con un promedio de duración de 30 días antes del ingreso. El 83,3?% tenía diagnóstico de VIH, con niveles de CD4 por debajo de 50 células/mm3 y recuentos elevados de carga viral. El líquido cefalorraquídeo mostró en más del 50?% hipertensión intracraneal, pleocitosis de predominio linfocitario, hiperproteinorraquia e hipoglucorraquia. El tipo de patógeno aislado más frecuente fue C. neoformans var neoformans. Las variables más prevalentes en el grupo de pacientes que fallecieron fueron la presencia de pleocitosis en LCR (p?=?0,025), cultivo para hongo positivo (p?=?0,02) y aislamiento C. neoformans var neoformans (p?=?0,03). Discusión: la criptococosis meníngea es una patología frecuente en hombres en la cuarta década de la vida y con infección por VIH, sin embargo, los factores relacionados con la mortalidad parecen variar dependiendo de la localización geográfica. Conclusión: en nuestro estudio los factores más prevalentes fueron la presencia de pleocitosis en LCR, cultivo positivo, aislamiento de C. neoformans var neoformans.

Introduction: Heart failure is a common, progressive, and life-threatening condition whose risk is often overestimated. Effective tools are required to discriminate the risk and therefore a system based on the assembly of neural networks was trained for this purpose. Objective: To present the results of the training and internal validation of a system based on a set of artificial neural networks for the prognosis of one-month mortality in patients hospitalized for acute heart failure, and to compare the results of each of the individual networks developed and four set systems simple voting and AdaBoost. Materials and method: From a cohort of 462 patients diagnosed with decompensated heart failure, 11 networks were trained and then assembled using four systems: simple voting, two systems weighted by operating characteristics (predictive values and likelihood ratios) and Boosting. Operating characteristics for the 30-day prognosis of death were calculated and compared with two clinical rules and logistic regression applied to the same population. Results: The various ensemble methods had a better prognostic performance than each of the networks that composed them. Voting weighted by predictive values performed best, with an accuracy of 89.0% (95% CI: 82.6-93.2%) although the results’ confidence intervals overlapped. Conclusions: The ensemble of neural networks through voting weighted by predictive values showed an adequate performance for predicting 30-day mortality in acute heart failure. [ABSTRACT FROM AUTHOR]

Introduction: dysphagia is a common complication of stroke, and serum albumin is widely recognized as a strong prognostic marker of health and/or disease status. However, the correlation between dysphagia and serum albumin levels has not been established. Objectives: to observe the correlation between dysphagia and serum albumin levels and prognosis in patients with stroke. Methods: we performed a retrospective study of patients hospitalized between June 1, 2018, and June 1, 2022. A total of 1,370 patients were enrolled. The patients were divided into two groups: dysphagia and non-dysphagia. Binary logistic regression and multiple linear regression models were used to analyze the correlation between dysphagia, albumin, modified Rankin Scale (mRS), activities of daily living (ADL), and length of hospital stay (LOS). Results: after adjusting for confounding factors, the risk of pneumonia in the dysphagia group was 2.417 times higher than that in the non-dysphagia group (OR = 2.417, 95 % CI: 1.902-3.072, p = 0.000). The risk of mRS ≥ 3 and modified Barthel index (MBI) < 60 in patients with dysphagia was 3.272-fold (OR = 3.272, 95 % CI: 2.508-4.269, p < 0.001) and 1.670-fold (OR = 1.670, 95 % CI: 1.230-2.268, p < 0.001), respectively; and the risk of hypoproteinemia was 2.533 times higher (OR = 2.533, 95 % CI: 1.879-3.414, p = 0.000). Stepwise linear regression showed that dysphagia was significantly correlated with lower albumin levels and higher mRS, lower ADL, and longer LOS in patients with stroke (β = -0.220, β = 0.265, β = -0.210, and β = 0.147, respectively; p < 0.001). Conclusions: dysphagia in patients with stroke is associated with decreased albumin levels and has an impact on its prognosis. [ABSTRACT FROM AUTHOR]

In this research, a 24 hours power generation forecast system is presented for photovoltaic facilities connected to the National Power Grid in Cuba. The system described, is based on the numerical weather forecast model WRF, which is run operationally four times a day at the Center of Atmospheric Physics of the Institute of Meteorology of Cuba. The system deliveries each day about the time of 7:00 AM the hourly forecasts of power generation for the next day, for a set of photovoltaic (PV) parks, so the National Charge Dispatch Office (DNC), which is responsible for planning the amount of energy to be generated in order to meet the estimated demand, can take into account the contribution of these facilities, which can be fluctuating in dependence of the weather conditions. The system forecasts are evaluated against power generation and solar radiation data, which is reported daily from each park. [ABSTRACT FROM AUTHOR]

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Copyright of Enfermería en Cardiologia is the property of Asociacion Espanola de Enfermeria en Cardiologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)