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Intraoral vertical ramus osteotomy (IVRO) is used to treat mandibular prognathism and temporomandibular disorders. However, the improvement of temporomandibular disorders after IVRO is considered to be due to the anterior and downward movement of the mandibular condyle, which may lead to condylar sag, and in the worst case, condylar luxation. In this retrospective cohort study, we examined factors potentially associated with condylar sag. Univariate analysis indicated that condylar sag was significantly associated with the following factors: magnitude of setback (P = 0.001), less than 3 mm setback (P < 0.001), presence of temporomandibular joint (TMJ) symptoms (P = 0.002), Wilkes classification (P = 0.039), occlusal cant correction ≥ 2 mm (P = 0.018), and mandibular condyle deformation (P < 0.001). Setback magnitude (P = 0.032) and TMJ symptoms (P = 0.007) remained significant in the multivariate analysis. In the receiver operating characteristic curve, the setback magnitude cut-off value for condylar sag after IVRO was 3.25 mm. Thus, the incidence of condylar sag after IVRO is increased with a smaller setback magnitude (≤ 3.25 mm) and the presence of TMJ symptoms. These factors should be evaluated by surgeons during treatment planning for IVRO to estimate condylar sag, and it may be possible to predict the risk of condylar luxation.

The present study aimed to detail the relationship between the flow and structure characteristics of the upper airways and airway collapsibility in obstructive sleep apnea. Using a computational approach, we performed simulations of the flow and structure of the upper airways in two patients having different facial morphologies: retruding and protruding jaws, respectively. First, transient flow simulation was performed using a prescribed volume flow rate to observe flow characteristics within upper airways with an unsteady effect. In the retruding jaw, the maximum magnitude of velocity and pressure drop with velocity shear and vortical motion was observed at the oropharyngeal level. In contrast, in the protruding jaw, the overall magnitude of velocity and pressure was relatively small. To identify the cause of the pressure drop in the retruding jaw, pressure gradient components induced by flow were examined. Of note, vortical motion was highly associated with pressure drop. Structure simulation was performed to observe the deformation and collapsibility of soft tissue around the upper airways using the surface pressure obtained from the flow simulation. At peak flow rate, the soft tissue of the retruding jaw was highly expanded, and a collapse was observed at the oropharyngeal and epiglottis levels. NEW & NOTEWORTHY Aerodynamic characteristics have been reported to correlate with airway occlusion. However, a detailed mechanism of the phenomenon within the upper airways and its impact on airway collapsibility remain poorly understood. This study provides in silico results for aerodynamic characteristics, such as vortical structure, pressure drop, and exact location of the obstruction using a computational approach. Large deformation of soft tissue was observed in the retruding jaw, suggesting that it is responsible for obstructive sleep apnea.

Mandibular prognathism is usually treated with mandibular setback surgery. However, this approach reduces the pharyngeal airway space, and can aggravate obstructive phenomena in patients with obstructive sleep apnea (OSA). While maxillary expansion is known to lead to an increase in the pharyngeal airway volume (PAS), its effect on the PAS in mandibular setback surgery has not yet been reported. The authors report a surgical approach with maxillary expansion in 2 patients with mandibular prognathism that was accompanied by OSA: maxillary midsagittal expansion with minimum maxillary advancement and minor mandibular setback without mandibular anterior segmental osteotomy (ASO) or major mandibular setback with mandibular ASO. Preoperative and postoperative computed tomography and polysomnography indicated that OSA was improved and pharyngeal airway space was increased or sustained, and the prognathic profile could be corrected to an acceptable facial esthetic profile. In summary, maxillary transversal expansion and mandibular setback with or without mandibular ASO can be successfully applied to treat mandibular prognathism with OSA.

Background/objectives: The aim of the study was to assess cephalometric predictive markers in terms of craniofacial morphology including posterior cranial fossa and upper spine morphology for mandibular advancement device (MAD) treatment outcome in patients with obstructive sleep apnoea (OSA)., Material/methods: Twenty-seven OSA patients were treated with MAD for 4 weeks. Apnoea-hypopnoea index (AHI) was recorded before and after MAD treatment. The criteria of treatment success were 75 per cent reduction of AHI. Accordingly, two groups occurred: the success treatment group of 8 patients and the no success treatment group of 19 patients. Before MAD treatment lateral cephalograms were taken and analyses of the craniofacial morphology including the posterior cranial fossa and upper spine morphology were performed. Differences between the groups were analysed by Fisher's exact test, t-test, and multiple regression analysis., Results: Upper spine morphological deviations occurred non-significantly in 25 per cent in the success treatment group and in 42.1 per cent in the no success treatment group. Body mass index (BMI; P < 0.05), maxillary prognathism (S-N-Ss; P < 0.01), mandibular prognathism (S-N-Pg; P < 0.05 and S-N-Sm; P < 0.01), and the distance between sella turcica and the deepest point in posterior cranial fossa (S-D; P < 0.05) was significantly smaller in the success treatment group. The maxillary prognathism (P < 0.05) was the most important factor for the MAD treatment outcome (R (2) = 0.47)., Limitations: Relatively small sample size., Conclusions: The results indicate that BMI, posterior cranial fossa morphology, and retrognathia of the jaws are factors related to MAD treatment outcome. Furthermore, OSA patients with upper spine morphological deviations may respond poorer to MAD treatment., (© The Author 2014. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Objective: To test the null hypothesis that mouth-breathing (MB) children by distinct obstructive tissues present a similar cephalometric pattern., Methods: The sample included 226 prepubescent children (113 MB and 113 nasal breathing (NB) controls). An ENT clinical examination, including flexible nasal endoscopy, orthodontic clinical and cephalometric examinations, was performed on the MB population. MB children were grouped into three categories, according to the obstructive tissues: 1) adenoid group (AG), 2) tonsillar group (TG), and 3) adenotonsillar group (ATG). The NB controls were matched by gender, age, sagittal dental relationship and skeletal maturation status. Lateral cephalometric radiography provided the cephalometric pattern comparisons between the MB and NB groups., Results: MB cephalometric measurements were significantly different from those of NB children, exception in the SNB° (P=0.056). All comparisons between the three groups of MB children with the NB children showed a significant difference. Finally, even among the three groups of MB children, a significant difference was observed in the measurements of the SNB° (P<0.036), NSGn° (P<0.028) and PFH/TAFH ratio (posterior facial height/total anterior facial height) (P<0.012)., Conclusions: The cephalometric pattern of MB and NB children was not similar. Cephalometric measurements of the MB group differed according to the etiology of upper airway obstruction. Children with isolated hypertrophy of the palatine tonsils presented with a mandible that was positioned more forward and upward compared to children obstructed only by the enlarged adenoid., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

This case report describes the successful treatment of a 29-year-old young woman who had severe bimaxillary dento-alveolar protrusion, with the four premolars already extracted. Her face was convex, with a closed naso-labial angle, protruding and everted lower lip, associated with mentalis strain and a class I canine and molar relationships. After retraction of anterior teeth by using maximum anchorage mechanics through directional forces, facial changes were impressive, with a significant improvement of the dento-alveolar protrusion. Retraction of the incisors had corrected proquelia, reduced lips eversion and had improved the chin projection. As the lips were retracted, mentalis strain was reduced; this improved chin projection.

Objective: The aim of this study was to compare the effects of group distal movement of lower teeth obtained with the aid of direct usage of miniscrews in the retromolar area and indirect usage of miniscrews in the posterior area of the maxillary., Methods: Nineteen patients with mild-to-moderate class III malocclusion (4 males and 15 females) were divided into 2 groups. Ten patients (2 males and 8 females; mean age, 20.7 ± 2.5 years) in group 1 were treated by miniscrews in the retromolar area. Nine patients (2 males and 7 females; mean age, 21.5 ± 3.7 years) in group 2 were treated by miniscrews in the posterior area of the maxillary. Lateral cephalometric headfilms were taken at the beginning of treatment and after distal movement of mandibular dentition for the evaluation of the treatment changes., Results: In group 1, the crown and root apex of lower first molars were moved distally by 3.4 mm and 1.2 mm with distal tipping of 8.7 degrees and intruded by 0.7 mm. In group 2, the crown and root apex of lower first molars were moved distally by 3.3 mm (P = 0.8976, P > 0.05) and 0.2 mm (P = 0.0124, P < 0.05) with distal tipping of 10.7 degrees (P = 0.0467, P < 0.05) and extruded by 0.2 mm (P = 0.0124, P < 0.05). Retraction of the mandibular arch lasted 6.31 ± 1.45 months for group 1 and 7.61 ± 1.46 months for group 2., Conclusions: Direct usage of miniscrews in the retromolar area took less time and more bodily movement to retract the lower arch without cooperation of the patients and was a better choice for the patients with potential temporomandibular joint disorders problems.

Introduction: This study was conducted to measure the dimensional changes in the cranial base and the mandible in patients with facial asymmetry and mandibular prognathism, and to examine the morphologic relationship between asymmetries of the cranial base and the mandible., Methods: The patients were 60 adults with mandibular prognathism, divided into a symmetry group (menton deviation, <2 mm; n = 30) and an asymmetry group (menton deviation, >4 mm; n = 30) according to the degree of menton deviation. Three-dimensional computed tomography scans were obtained with a spiral scanner. Landmarks were designated on the reconstructed 3-dimensional surface models. Linear, angular, and volumetric measurements of the cranial base and mandibular variables were made., Results: In the asymmetry group, the hemi-base, anterior cranial base, and middle cranial base volumes were significantly larger (P <0.01), and crista galli to sphenoid, sphenoid to petrous ridge, anterior clinoid process to petrous ridge, and vomer to petrous ridge lengths were significantly longer (P <0.05) on the nondeviated side than on the deviated side. Menton deviation was significantly correlated with the difference in hemi-base volume, and ramal volume was significantly correlated with the difference in hemi-base and middle cranial base volumes between the nondeviated and deviated sides (P <0.05)., Conclusions: In patients with facial asymmetry and mandibular prognathism, cranial base volume increased on the nondeviated side and was also correlated with mandibular asymmetry., (Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)

The use of bonded orthodontic molar tubes is becoming more prevalent in orthodontics because they have some advantages over conventional bonding. However, a bonded apparatus can become detached, leading to complications. This article presents the case of a submandibular-space abscess associated with a molar tube that detached during orthognathic surgery and became embedded in the soft tissues. The site became infected, and antibiotics were prescribed. Eventually, the molar tube migrated and could be removed under local anesthesia., (Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)

Persistent macroglossia affects speech, swallowing, and the dentofacial skeleton. A range of tongue reduction methods have been proposed to preserve the mobility and sensation of the tongue. However, recent reports have shown that speech or esthetic problems still exists, even after a comprehensive glossectomy in early childhood. Because a large volume reduction of the anterior tongue in young growing children might result in a short tongue tip with functional difficulties, it is important to select the appropriate tongue reduction method considering the growth of the tongue.In the current report, a staged tongue reduction was planned to minimize the functional and esthetic problems after surgery. A 3-year-old girl visited our clinic because of congenital macroglossia, phonation problems, and prognathic appearance of the mandible. The tongue was first reduced by a central glossectomy. The speech intelligibility, tongue movement, and skeletal growth pattern were improved after the first surgery. The secondary peripheral tongue reduction was performed 6 years later to achieve an esthetically pleasing tongue appearance.This 2-stage partial glossectomy, central tongue reduction first followed later by a peripheral tongue reduction, ensures functional integrity of the tongue and can provide an esthetically pleasing result in growing children. The results demonstrated that this strategic combination of a staged tongue reduction can be a successful treatment option for macroglossia.

Objective: To examine the prevalence of temporomandibular disorders (TMD) after orthodontic-surgical treatment in patients with mandibular prognathism and analyze psychosocial variables related to TMD., Materials and Methods: The case-control study comprised 40 patients with mandibular prognathism who underwent combined orthodontic-surgical treatment (orthognathic surgery group). Forty-two patients with untreated mandibular prognathism served as a control group. Research diagnostic criteria for temporomandibular disorders was used in order to assess the clinical diagnosis of TMD (Axis I) and to estimate depression, somatization and patient's disability related to chronic pain (Axis II)., Results: The overall prevalence of TMD was not significantly different between the groups. Myofascial pain was significantly higher, while arthralgia, arthritis and arthrosis was significantly lower in the orthognathic group compared with the controls (90.5% vs 50.0%, 0.0% vs 27.8%, respectively) (p < 0.05). Females in orthognathic surgery group showed higher prevalence of TMD (p < 0.05) and myofascial pain (p < 0.01) and increased level of chronic pain (p < 0.05) in comparison with post-operative males. No significant difference in chronic pain, somatization and depression scores was found between investigated groups. With respect to presence of TMD within the groups depression was higher in untreated subjects with dysfunction (p < 0.05)., Conclusion: Prevalence of TMD immediately after completion of orthodontic-surgical treatment for mandibular prognathism is similar to frequency of dysfunction in untreated subjects, is significantly higher in females and is most commonly myogenic. Furthermore, females show an increased level of chronic pain post-operatively. Somatization and depression levels do not differ between patients with corrected prognathism and untreated prognathic patients.

The aim of this work was to update the bibliography regarding the concept of 'temporomandibular disorder (TMD)' and 'posterior crossbite' and try to find out if there is any association between some special signs/symptoms of TMD and type of posterior crossbite. A literature search from 1970 to 2009, due to specified criterion, resulted in 14 publications that were found to be relevant for the present systematic review. An association between TMD and posterior crossbite (Yes-group) was reported as often as absence of such a relationship (No-group). The samples in the two groups showed similarities as well as differences with respect to number, gender, and age. Most articles reported only on 'presence' or 'absence' of crossbite and only few on type of crossbite opposite to a thorough account of clinical signs and symptoms of TMD. This review seems, however, to state that a functional posterior crossbite (mandibular guidance with midline deviation) is associated with headache, temporomandibular joint and muscular pain, and clicking. As evident from the discussion, such type needs orthodontic treatment to rehabilitate the asymmetric muscular activity between the crossbite and non-crossbite sides and the changed condyle/temporal relationship caused by mandibular deviation. Whether this treatment also will avoid future TMD problems can be answered only after clinical follow-up studies have been performed.

Objectives: To evaluate the alveolar bone loss around lower incisors incurred during surgical orthodontic treatment in individuals with mandibular prognathism., Materials and Methods: The samples consisted of 25 patients (13 men, 12 women; mean ages: 26.3 ± 2.7 years) treated with jaw surgery and orthodontic treatment. Lateral and frontal cephalograms and cone-beam computed tomography (CBCT) images of the patients were obtained before treatment (T0) and after presurgical orthodontic treatment (T1) and after debonding (T2). After measurement of variables, repeated-measures analysis of variance with Bonferroni's multiple comparison test and Pearson and Spearman correlation analysis were performed., Results: The lower central and lateral incisors showed that the vertical alveolar bone level and the alveolar bone thickness of the labial and lingual plates were reduced after presurgical orthodontic treatment but were not deteriorated during postsurgical orthodontic treatment., Conclusion: Excessive forward movement of lower incisors during presurgical orthodontic treatment could cause alveolar bone loss around the lower incisors; thus, special care should be considered in individuals with mandibular prognathism.

Background: Prognathism of the mandible is a skeletal Class III abnormality, caused either by excessive forward growth of the mandible or maxillary underdevelopment., Objectives: The aim of the study was to assess dynamic changes in morphometric analysis on subjects presenting with Class III malocclusions before orthodontic treatment, before bimaxillary surgery and after surgery., Material and Methods: The sample consisted of 30 non-growing patients, at the age of 18 to 30, treated with mandibular set-back sagittal split osteotomy and maxillary Le Fort I advancement. Cephalometric analysis by Segner and Hasund was performed. Lateral cephalograms were taken at the beginning of orthodontic treatment (T0), immediately before surgery (T1) and at least 3-6 months after surgery (T2)., Results: The results showed that there was normalization of the cephalometric variables after surgery. In the sagittal plane the following skeletal changes were observed: preoperative anterior mandibular growth confirmed by SNB increased angle was significantly reduced after surgery; preoperative decreased SNA angle largely increased after surgery. Statistically significant GntgoAr mandible angle decreased after surgery in relation to the beginning state. Also, the H angle was increased as a result of orthodontic-surgical treatment which influenced positively on face esthetics., Conclusions: The results of our study indicate that there was a significant improvement in the correlation between soft and hard tissue change in the facial profiles of the Class III bimaxillary surgery patients, which was improved by the H angle. The face's photographs and cephalometric analysis indicate, after the operation there is a decrease of total face length, but the lower part still remains longer than a middle part of the face.

Objective: To examine and compare the maxillofacial characteristics affecting chin deviation three-dimensionally in facial asymmetry patients with mandibular retrusion and mandibular prognathism., Materials and Methods: Maxillofacial computed tomography (CT) scan data were obtained from 48 orthognathic surgery patients (24 cases of mandibular retrusion and 24 cases of mandibular prognathism) with facial asymmetry. Although chin deviation was assessed on the basis of the ANS-to-menton line on frontal cephalograms, its contributing factors were evaluated on three-dimensional CT images. Maxillary height, ramus length, frontal ramal inclination, lateral ramal inclination, mandibular body length, and body height were defined on each side, and right-left differences were calculated and analyzed., Results: In an assessment of chin deviation, subjects in this study showed predominantly left side deviation regardless of the group, and the degree of menton deviation did not reveal significant differences between groups. In a comparison of right-left differences in contributing factors, all values were noted to be greater in the retrusion group, except for body height, which showed no difference between chin-deviated and contralateral sides. In particular, ramus length presented a statistically significant difference between the two groups., Conclusion: Based on the same degree of chin deviation in mandibular prognathism and retrusion in this study, results of right-left differences in contributing factors indicate that chin deviations are expressed easily in mandibular prognathism, whereas they occur only with significant right-left differences in relevant maxillofacial structures in individuals with mandibular retrusion.

Acromegaly is an acquired disorder related to excessive production of growth hormone after epiphyseal closure of bones. It is characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. The prevalence is estimated at 1:140,000-250,000. Although acromegaly rarely manifests in the orofacial regions, it must be considered in patients who develop malocclusion after adolescence. Here, we present a case of acromegaly with brief review of the literature.

The purpose of this study was to evaluate changes in stress on the temporomandibular joint (TMJ) in 80 Japanese subjects (21 males and 59 females, mean age 23.7 years) with mandibular prognathism, with and without asymmetry after orthognathic surgery using the rigid bodies spring model (RBSM). The asymmetric group consisted of 40 subjects whose Mx-Md midline was more than 3 degrees. The remaining 40 subjects formed the symmetric group. The geometry of the stress analysis model was based on frontal cephalograms of the subjects. Menton (Me), the centre point of occlusal force on a line connecting the bilateral buccal cusps of the second molars, and the most lateral, superior, and medial points on the condyle were plotted on a computer display and stress on the condyle was calculated with the two-dimensional RBSM program, Fortran. The degree (force partition) of the resultant force, the direction (angulation), and the displacement (X, Y) of each condyle were calculated and the horizontal displacement (u), the vertical displacement (v), and rotation displacement (theta) of the mandibular body at Me were calculated pre- and post-operatively. The data was analysed using paired and unpaired t-tests. For the vertical (v) and rotational (theta) displacement, the post-operative value was smaller than the pre-operative value (v: P < 0.001, theta: P = 0.0063) in the asymmetric group. For angulation and the X-component, the post-operative value was smaller than that pre-operatively on the deviated (angulation: P = 0.0074, X-component: P = 0.0003) and non-deviated (angulation: P = 0.0024, X-component: P = 0.001) side in the asymmetric group. However, there was no significant difference between the pre- and post-operative value for any parameter in the symmetric group. These findings suggest that surgical correction of mandibular prognathism, with and without asymmetry, could induce an improvement in stress balance on the TMJ in the frontal aspect.

Purpose: To evaluate the morphologic outcome after total maxillary setback osteotomy (TMSO) in dentofacial Class II deformity patients with marked upper jaw prognathism., Patients and Methods: The assessments of 9 patients before and after TMSO were compared. The evaluation was based upon x-ray superimpositions and standardized photographic comparison. TMSO was performed through a conventional Le Fort I operation with resection of the inferior end of the pterygoid processes., Results: All patients presented with marked upper jaw prognathism initially and have had a bimaxillary surgery with a mean maxillary setback of 3.1 mm. All patients ended in Class I occlusion after at least 1-year of follow-up. An opening of the nasolabial angle (mean 8.9 degrees) was noted for all but 2 patients. At the same time, the suborbital profile was nicely modified as a result of substantial heightening of the prezygomatic soft tissues in all patients, even without vertical maxillary intrusion., Conclusions: These results challenge the notion of unavoidable facial alteration commonly associated with upper setbacks. TMSO allows combining satisfactory functional and cosmetic results for a number of carefully selected patients. Pronounced maxillary protrusion with acute nasolabial angle is a prerequisite. The release of the deforming strains of the dysmorphosis upon the midface will improve the suborbital profile. Bimaxillary surgery is recommended to leverage the setback and the opening of the naso-labial angle., (Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)

Objective: Aim of this study was to investigate the differences in stress on the temporomandibular joint (TMJ) between Class III patients with and without mandibular asymmetry using a rigid body spring model (RBSM)., Design: Menton (Me), the centre point of occlusal force on the line that connected the bilateral buccal cusps of the second molars and the most lateral, superior and medial points of the condyle were plotted on frontal cephalograms, and stress on the condyles was calculated with the 2-dimensional RBSM program of fortran., Setting and Sample Population: Eighty Japanese patients with diagnosed mandibular prognathism were divided into two groups, a symmetry group and asymmetry group on the basis of the Mx-Md midline position., Outcome Measure: The degree (force partition) of the resultant force, the direction (angulation) and displacement (X, Y) of each condyle were calculated. The horizontal displacement vector (u), the vertical displacement vector (v) and rotation angle (theta) of the mandibular body at Menton were also calculated., Results: There were significant differences between the deviated and non-deviated sides of both groups regarding resultant force (symmetry group: p = 0.0372, asymmetry group: p = 0.0054), X (symmetry group: p < 0.0001, asymmetry group: p = 0.0001) and Y (symmetry group: p = 0.0354, asymmetry group: p = 0.0043). For angulation, there was a significant difference between the deviated and non-deviated sides in the asymmetry group (p = 0.0095)., Conclusion: The results of this study suggest that difference in stress angulation on the condyles could be associated with asymmetry in mandibular prognathism.

Aim: To evaluate left and right masseter and anterior temporalis muscle activity in patients before and after orthognathic surgery., Patients: Nineteen patients were enrolled, 9 males and 10 females, aged 17-34 years. Four patients were suffering from a prognathic syndrome (skeletal class II with mandibular retrusion) and were candidates for surgical correction involving a mandibular Bilateral Sagittal Split Osteotomy (BSSO), whereas the other 15 patients showed a progenic syndrome (skeletal class III with mandibular protrusion) and were selected for bimaxillary surgery with maxillary advancement and mandibular retrusion., Methods: Electromyographic examinations were carried out on all subjects presurgically and 6-8 months postoperatively. To verify the neuromuscular equilibrium, the electromyographic activities of both the right and left masseter and anterior temporalis muscles were registered and analysed calculating: percentage overlapping coefficient (POC, index of the symmetric distribution of the muscular activity determined by the occlusion) and torque coefficient (TC, index of presence of mandibular torque)., Results: After surgery, a trend in the improvement of POC and TC indices was found, with a reduced intragroup variability., Conclusion: The electromyographic evaluation allowed the impact of occlusion on neuromuscular equilibrium to be quantified, and showed that improvements gained by surgical intervention are primarily due to better occlusal stability and not to biomechanical advantages.

Purpose: We examined the movement of the mandible in skeletal Class III patients with a unilateral posterior cross-bite to clarify whether the correction of the cross-bite caused conversion of the masticatory movement from a reverse to a grinding pattern., Materials and Methods: We studied 10 adults with mandibular prognathism who had been treated with surgery. The masticatory movement and rhythm (cycle time) during gum chewing were recorded before and after treatment., Results: The results before treatment demonstrated a high frequency of patterns IV, VI, and VII and a low frequency of patterns I, II, and III on the cross-bite side. After treatment, the masticatory movement on the cross-bite side showed different patterns than from before treatment. The high frequency of pattern VI (reverse pattern) before treatment was significantly reduced, and patterns I and III had significantly increased in frequency after treatment. No significant changes were seen in cycle time, opening phase, occlusal phase, or the closing phase before and after treatment., Conclusions: These results suggest that correction of a unilateral posterior cross-bite induces conversion of the masticatory pattern from the reverse pattern to the grinding pattern.

The effect of combined orthodontic and orthognathic treatment was studied retrospectively in 24 patients with skeletal class III malocclusions with mandibular hyperplasia, particularly the effect on temporomandibular joint (TMJ) disc position. The patients underwent preoperative orthodontic treatment, orthognathic surgery, and postoperative orthodontic treatment. The patients were studied clinically, radiographically with lateral cephalometric radiograph and MRI to locate the position of the TMJ disc in relation to the glenoid fossa. One patient had less pain after treatment, one lost abnormal joint clicking sounds after treatment. There were no TMJ symptoms in 20 of the 24 preoperatively and postoperatively. 48 sagittal MRI images showed that the disc length before treatment was 3.040-12.928 (mean 8.289+/-2.028) and after treatment was 3.699-11.589 (mean 8.097+/-1.966); results were not significant (p>0.05). Maximum disc displacement before treatment was 6.090 (mean 1.383), after treatment it was 11.931 (mean 2.193); results were not significant (p>0.05). The results suggest that combined orthodontic and orthognathic treatment (including bilateral SSRO and rigid internal fixation) can be used safely to correct skeletal class III malocclusion with mandibular hyperplasia without causing additional TMJ symptoms.

Objective: To investigate the 3-dimensional (3D) changes in the hard and soft tissues of skeletal class III malocclusion (CIII) patients with or without facial asymmetry by mandibular setback surgery (MSS)., Study Design: Seventeen adult CIII patients treated with MSS (bilateral sagittal split ramus osteotomy) who had 3D computerized tomography taken 1 month before (T0) and 6 months after (T1) MSS, were allocated into group 1 (symmetry, menton deviation (MD) <4 mm; n = 8) or group 2 (asymmetry, MD >4 mm; n = 9). The landmarks and variables were measured with Rapidform 2006 (Inus Technology)., Results: Mandibular prognathism was significantly corrected in both groups. Facial asymmetry in group 2 was significantly corrected not only in the lower lip and chin but also in the philtrum deviation and mouth corner of the deviated side. The hard and soft tissue changes were more related in the horizontal and anteroposterior aspects than in the vertical one., Conclusion: Three-dimensional evaluation showed a significant difference in the hard and soft tissue changes between symmetric and asymmetric MSS.

Introduction: Our aim in this study was to investigate the position of the glenoid fossa in subjects with Class III malocclusion associated with mandibular protrusion to better clarify the role of this craniofacial component in Class III skeletal disharmony., Methods: A sample of 30 subjects, aged 8 years +/- 6 months, with skeletal and dental Class III malocclusion associated with mandibular protrusion, normal skeletal vertical relationships, and normal mandibular dimensions, was compared with a control group of 33 subjects with skeletal and dental Class I relationships. The comparisons between the Class III group and the control group on the cephalometric measures for the assessment of glenoid fossa position were performed with the Mann-Whitney U test at P <0.05., Results: Subjects with Class III malocclusion had a significantly more mesial position of the glenoid fossa, when compared with the control group as measured with 3 parameters., Conclusions: An anterior position of the glenoid fossa is a possible diagnostic anatomic feature of Class III malocclusion associated with mandibular protrusion. An effective measurement to evaluate glenoid fossa position in craniofacial relationships is the cephalometric distance from the glenoid fossa to the frontomaxillary-nasal suture.

Tricho-rhino-phalangeal syndromes (TRPS) are caused by mutation or deletion of TRPS1, a gene encoding a GATA transcription factor. These disorders are characterized by abnormalities of the hair, face, and selected bones. Rare cases of individuals with TRPS displaying supernumerary teeth have been reported, but none of these has been examined molecularly. We used two different approaches to investigate a possible role of TRPS1 during tooth development. We looked at the expression of Tprs1 during mouse tooth development and analyzed the craniofacial defects of Trps1 mutant mice. In parallel, we investigated whether a 17-year-old Thai boy with clinical features of TRPS and 5 supernumerary teeth had mutation in TRPS1. We report here that Trps1 is expressed during mouse tooth development, and that an individual with TRPS with supernumerary teeth has the amino acid substitution A919V in the GATA zinc finger of TRPS1. These results suggest a role for TRPS1 in tooth morphogenesis.

Binder syndrome or maxillo-nasal dysplasia (nasomaxillary hypoplasia) is an uncommon developmental anomaly affecting primarily the anterior part of the maxilla and nasal complex. A 4-year-old boy with maxillo-nasal dysplasia (Binder's syndrome), featuring maxillary hypoplasia and relative mandibular prognathism, combined with acute leucosis was presented. We review the literature and describe how three-dimensional CT scanning was used to evaluate the facial morphology. The principal features, diagnosis and management of the syndrome are discussed.

Transdermal scopolamine has been shown to be very useful in the management of drooling, particularly in patients with neurological or neuropsychiatric disturbances or severe developmental disorders. In this paper, we present the case of a 24-year-old patient with a diagnosis of cerebral palsy and a severe problem of drooling, exacerbated by marked mandibular prognathism. After exclusion of other therapeutic alternatives, it was decided to use sustained-release transdermal scopolamine patches (Scopoderm TTS). This technique consists of the application every three days of a patch with 1.5 mg of scopolamine in the area of the mastoid apophysis; the patch releases a dose of 0.5 mg of the active substance over each 24 hour period. The patient underwent periodic clinical and laboratory follow-up over a period of three years, achieving satisfactory results with no significant undesirable effects.

Aim: To present the dentofacial changes produced by mandibular body ostectomy in a female patient, 19 years of age, and the patient's 2-year follow-up records., Subject and Treatment: An increased lower facial height and a prominent chin, Angle Class III molar relationship, edentulous gaps in the first premolar regions of the mandible, with overjet and overbite values of -1 mm were observed. Radiographic evaluations revealed impaction of the maxillary right canine. The treatment plan included leveling and coordination of the arches, extraction of the maxillary left first premolar and the impacted canine, and a "rectangular" body ostectomy of 5 mm., Results: Treatment lasted for 24 months. An increase of ANB was observed. Normal overjet and overbite were established. The posterior movement of the lower lip and soft and hard tissue points B and Pg were observed. No major changes were observed for the dentofacial structures at the 2-year follow-up visit. However, slight spacing at the ostectomy sites was present., Conclusion: The rectangular mandibular body ostectomy might be considered an alternative effective method for the correction of mandibular prognathism, particularly when the posterior occlusion is to remain unchanged and when edentulous gaps in the anterior region of the mandible are present.

Objective: To examine if there was any correlation between the labio-lingual inclinations of the mandibular central incisor and the associated alveolar bone, and to investigate the labio-lingual position of the mandibular central incisor root apex in the associated cancellous bone in adults with untreated mandibular prognathism., Materials and Methods: High-resolution computed tomography images of the mandible were recorded in 20 adult patients with mandibular prognathism. The labio-lingual inclinations of a central incisor and its associated alveolar bone, the thickness of the associated cancellous bone, and the distance from the central incisor root apex to the inner contour of both the labial and lingual cortical plates were measured. Correlations and differences between the measured variables were tested for statistical significance., Results: The labio-lingual inclination of the central incisor significantly correlated with the labio-lingual inclination of the associated alveolar bone, the thickness of cancellous bone, and the distance from the central incisor root apex to the inner contour of the lingual cortical bone. The distance from the central incisor root apex to the inner contour of the labial cortical plate of bone was significantly smaller than that to the lingual cortical plate., Conclusions: In adults with untreated mandibular prognathism, when the mandibular central incisor was more lingually inclined, the associated alveolar bone was also more lingually inclined and thinner. The mandibular central incisor root apex was closer to the inner contour of the labial cortical bone than to the lingual cortical bone.

Purpose: The purpose of the present study was to evaluate the relationship between masticatory muscle volume and mandibular skeletal measurements in patients with and without facial asymmetry. This was done in order to determine whether asymmetric mandibular prognathism is related to masticatory muscle asymmetry., Patients and Methods: The study was conducted with 40 adult patients with mandibular prognathism composed of 2 groups, the asymmetry group (n = 20) and the nonasymmetry group (n = 20). Using 3-dimensional reformatted computed tomography (CT) images, the volume of masticatory muscle (masseter, temporal, medial, and lateral pterygoid muscles) and various skeletal measurements (hemimandibular volume, ramal height, body length, mandibular length, gonial angle) were evaluated and compared. The right-left difference was expressed by an asymmetry index {(right-left)/left, %}., Results: The results showed that in the asymmetry group, the longer mandibular side (contralateral side of chin deviation) exhibited longer ramal and body length, a wider gonial angle, and more hemimandibular volume with less medial pterygoid volume, whereas the nonasymmetry group did not show a statistical bilateral difference between the skeletal and muscular measurements. The correlation analysis showed that patients with facial asymmetry did not have similar patterns of muscle-bone relation as compared with the symmetrical subjects., Conclusion: In patients with mandibular prognathism, the bilateral difference in muscle volume would reflect the difference in the spatial anatomy of a skeletal structure and could not predict mandibular skeletal asymmetry.

The aim of this study was to evaluate skeletal, dentoalveolar, and soft tissue profile changes with activator and high-pull headgear combination therapy in patients with Class II malocclusions caused by maxillary prognathism and mandibular retrognathism. The subjects, all in the mixed dentition, were selected from a single centre and were divided into two groups: 28 patients were treated with an incisor double capping activator and a high-pull headgear combination appliance (13 girls, 15 boys mean chronological age 11.7 +/- 1.2 years, skeletal age 12.1 +/- 1.4 years) and an untreated group of 28 subjects (14 girls, 14 boys mean chronological mean age 11.9 +/- 1.1 years, skeletal age 12.3 +/- 1.3 years). The skeletal, dentoalveolar, and soft tissue profile changes that occurred were compared on lateral cephalograms taken before treatment (T0) and after 1.1 +/- 0.3 years when the combination appliance was removed (T1). In the control group, the radiographs were obtained at the start (T0) and after an observation period 1.2 +/- 0.4 years (T1). Statistical analysis was undertaken with Wilcoxon's ranked-sum test for intra-group comparisons and differences between groups with t-test and Bonferroni's test at a level of significance of P < 0.05. Activator and high-pull headgear combination treatment in these growing patients resulted in a correction of the skeletal Class II relationship (ANB -3.4 degrees), a restriction of maxillary growth (SNA -2.0 degrees, OLp-A -2.3 mm), an advancement of the mandibular structures (SNB +2.6 degrees, FH-NPg +2.3 degrees, OLp-B +2.7 mm, OLp-Pg +2.2 mm), an increase in lower face height (ANS-Me +3.9 mm), a correction of the overjet (-5.4 mm), an improvement in overbite (-2.2 mm), uprighting of the maxillary incisors (U1-FH -5.3 degrees, OLp-U1 -2.5 mm), protrusion of the mandibular incisors (IMPA +2.0 degrees, OLp-L1 +2.7 mm), and a correction of the dental Class II malocclusion (OLp-L6 +3.5 mm). The soft tissue profile changes were a correction of facial convexity (G'-Sn-Pg' angle 2.3 degrees, Mlf-Li-x-axis angle 9.1 degrees), and an increase in lower antero-posterior (Mlf-y-axis 5.6 mm, Pg'-y-axis 5.3 mm), and lower vertical (Sls-x-axis 3.8 mm, Pg'-x-axis 3.8 mm, Me'-x-axis 5.1 mm) soft tissue dimensions. The mentolabial fold depth (Mlf-E line) also significantly decreased, -0.8 mm in the treated group. The activator and high-pull headgear combination appliance was effective in treating growing patients with maxillary prognathism, mandibular deficiency, and facial convexity by a combination of skeletal and dentoalveolar changes and improvement in the soft tissue facial profile.

The purpose of this study was to examine the changes in temporomandibular joint (TMJ) morphology and clinical symptoms after intraoral vertical ramus osteotomy (IVRO) with and without a Le Fort I osteotomy. Of 50 Japanese patients with mandibular prognathism with mandibular and bimaxillary asymmetry, 25 underwent IVRO and 25 underwent IVRO in combination with a Le Fort I osteotomy. The TMJ symptoms and joint morphology, including disc tissue, were assessed preoperatively and postoperatively by magnetic resonance imaging and axial cephalogram. Improvement was seen in just 50% of joints with anterior disc displacement (ADD) that received IVRO and 52% of those that received IVRO with Le Fort I osteotomy. Fewer or no TMJ symptoms were reported postoperatively in 97% of the joints that received IVRO and 90% that received IVRO with Le Fort I osteotomy. Postoperatively, there were significant condylar position changes and horizontal changes in the condylar long axis on both sides in the two groups. There were no significant differences between improved ADD and unimproved ADD in condylar position change and the angle of the condylar long axis, although distinctive postoperative condylar sag was seen. These results suggest that IVRO with or without Le Fort I osteotomy can improve ADD and TMJ symptoms along with condylar position and angle, but it is difficult to predict the amount of improvement in ADD.

Objective: The purpose of this study was to explore the association of hypodontia patterns and variations in craniofacial morphology in Japanese orthodontic patients., Materials and Methods: A total of 50 girls with hypodontia (the total group) were selected and categorized into anterior, posterior, and anterior-posterior groups according to the location of the congenitally missing teeth. By using the lateral cephalograms of each subject, 28 angular and 37 linear measurements were made. The cephalometric data were statistically analyzed and compared among the groups and with the Japanese cephalometric standards from 36 age-matched female subjects without hypodontia or malocclusion (the control group)., Results: Every hypodontia group showed shorter anterior and overall cranial base lengths, shorter maxillary length, greater retroclination and elongation of mandibular incisors, and a larger interincisal angle than the control group. The total and anterior-posterior groups especially exhibited a significantly more prognathic mandible, larger retroclination of maxillary incisors, and a more counterclockwise-rotated occlusal plane. Furthermore, these skeletal and dental deviations were more remarkable in the anterior-posterior group than in either the anterior or the posterior group. Anterior hypodontia exerted as much influence on craniofacial morphology as posterior hypodontia., Conclusions: When orthodontic treatment is performed on patients with hypodontia, not only the number but also the distribution of missing teeth should be taken into consideration, though there was no significant difference in craniofacial morphology between anterior hypodontia and posterior hypodontia.

Purpose: The purpose of this study was to examine the relationship between the morphologies of the masseter muscle and the ramus and occlusal force in patients with mandibular prognathism., Patients and Methods: The study group consisted of 71 patients with mandibular prognathism. They were divided into 2 groups, consisting of prognathism with or without symmetry, determined by frontal cephalogram analysis. All patients underwent 3-dimensional (3D) computed tomography (CT) and occlusal force was recorded with pressure-sensitive sheets., Results: In the cross-sectional area of masseter muscle, there were no significant differences between the right and left sides in the symmetry and asymmetry groups. In occlusal force, there was no significant difference between the symmetry and asymmetry groups. Occlusal force was not significantly correlated to the cross-sectional area of the ramus, but it was significantly positively correlated to the cross-sectional area of the masseter muscle (P < .05)., Conclusion: Occlusal force was associated with the ipsilateral cross-sectional area of masseter muscle in patients with prognathism; however, it was not associated significantly with the degree of mandibular deviation.

Coffin-Lowry Syndrome is characterized by mental retardation, skeletal abnormalities, delayed bone development, short stature, tapered fingers, large ears, orbital hypertelorism, anteverted nares, and a prominent frontal region. This inherited disorder is x-linked and is genetically mapped to the Xp22.2 chromosomal region. This report presents the dental findings of three male members of the same family: an older brother and younger identical twins; all three were first examined at age 10. The father's family came from North Africa and the mother's from Eastern Europe. In addition to the reported typical characteristics of Coffin-Lowry Syndrome, a number of specific dental findings were found in all of the brothers, namely, maxillary protrusion, open bite, two-year retardation in age of eruption, agenesis of the permanent mandibular central incisors in all of the brothers, and a marked oligodontia in the oldest. Despite difficulties in management, the dental treatment for caries and gingivitis could be completed on the brothers without sedation.

A 2-stage procedure combining maxillary advancement by distraction technique with mandibular setback surgery was used to correct jaw deformities in 5 patients with severe maxillary retrusion secondary to cleft lip and palate. First, a Le Fort I maxillary osteotomy was performed. Immediately after maxillary distraction, the distraction device was removed. The advanced maxilla was fixed with miniplates after adjusting the length and direction of advancement, and mandibular setback surgery was performed simultaneously to obtain a normal occlusal relationship. This 2-stage procedure resulted in stable occlusion and a markedly improved facial profile.

The aim of the present study was to evaluate the swallowing patterns of the tongue using B-mode sonography. A total of 65 patients aged between eight and 35 years were enrolled in the study including 25 controls. The swallowing patterns of the 40 patients were divided into groups of ten normal, 12 inconsistent, and 18 abnormal. Eight patients with a swallowing abnormality had Angle Class I occlusions, two had Class II, and the remaining ten patients had Class III. The majority of abnormal or inconsistent swallowing patterns were found in cases of mandibular prognathism. Quantitative data was not analyzed in this study. The results of this study show that B-mode sonography, being a non-invasive procedure permitting direct visualization of the movements of the tongue in both coronal and sagittal planes, can be used with certainty for diagnosing swallowing abnormalities.

Objective: To investigate the morphology of the temporomandibular joints (TMJ) in skeletal asymmetry with prognathism., Design: Three-group observational clinical study., Setting and Sample Population: University setting. Thirty-five patients undergoing orthognathic surgery without signs and symptoms of TMJ disorder were assigned to three groups (right deviation, n = 11; left deviation, n = 14; and non-deviation; n = 10) based on anteroposterior cephalometric analysis., Outcome Measure: Positional and morphological differences of the TMJs were evaluated using a total of 70 bilateral sagittal TMJ magnetic resonance images., Results: In both the right and left deviation groups, the TMJ on the deviated side showed a significantly steeper eminence than that on the non-deviated side (p < 0.05). The anterior joint space was narrower on the deviated side than on the non-deviated side whereas the posterior joint space did not differ markedly, indicating an anterior position of the condyle in the glenoid fossa of the TMJ on the deviated side. Disk displacement comparisons revealed no significant differences between left and right sides in the symmetry or asymmetry group., Conclusion: Asymmetrical prognathism patients exhibit significant morphological differences between the right and left TMJs concerning the slope of the articular eminence, which correspond to facial asymmetry.

A healthy white man with marked facial and dental asymmetry, a consequence of unilateral mandibular condylar hyperplasia, was treated with conventional fixed edgewise appliance therapy combined with orthognathic surgery (bilateral sagittal split osteotomy of the mandibular ramus). Pretreatment, posttreatment, and long-term follow up records for the patient at ages 26 years 11 months, 28 years 6 months, and 58 years 7 months are presented. Thirty years after treatment, the results remain stable. The pretreatment and posttreatment records were presented to the American Board of Orthodontics in 1976 in partial fulfillment of the requirements for board certification.

The field of minimally invasive surgery is defined as the combination of surgical innovation with modern technology. This article describes the history of surgery and newer developments in endoscopic surgery for mandibular orthognathic surgery.

Surgical orthodontic treatment and dental implant therapy were performed on a man (aged 18 years 8 months) with mandibular prognathism and seven congenitally missing teeth: upper canines, first and second premolars and lower right second premolar. After 17 months of preoperative orthodontic treatment at age 20 years 1 month, sagittal split ramus osteotomy was performed using the remaining upper deciduous teeth as an anchor for intermaxillary fixation. In postoperative orthodontic treatment, the remaining deciduous teeth were extracted, and fixture installation was performed. The entire therapy required 4 years to complete (age 22 years 8 months). After completion of orthodontic treatment, superstructures were put in place. This patient had many dental problems, so multidisciplinary care was performed in conjunction with other departments to improve oral function and facial esthetics.

Purpose: This work presents the results of research on the guality of articulation of patients with occlusion defects. Freguency of occurence the following matters has been presented: defects of speech, defective articulation of Polish consonantal phonemes, and undesirable phonetic features of non-normative articulation of phonemes., Material and Methods: This study was done in 23 patients with mandibular prognathism., Results: All subjects participating in this study were found to have speech disorders. Distortions in the phonation of Polish consonant phonemes /s, z, c, dz/, /ś, ź, ć, dź, ń, j/, /t, d, n/, /sz, z, cz, dz, l, r/ and /f, w / were found. Failure to elevate the tongue to various degrees during articulation was the most frequent undesirable manner of phonation. Disorted phonation in persons with mesioccusion seems to be caused by anatomical and functional abnormalities of the maxillofacial structure or anterior displacement of the tongue and the hyoid bone., Conclusion: Due to the frequent nature of speech disorders and serious articulation defects in persons with mandibular prognathism, the team of professionals treating this abnormality should include a speech therapist.

Introduction: The view on the role of the tongue in the etiology of dentofacial malformations and relapse after orthognathic surgery has changed over years., Purpose: The aim of this study was to determine the clinical and metric size of the tongue in patients with madibular prognathism in comparison with persons with normal face anatomy., Materials and Methods: A noninvasive study was conducted at the Department of Cranio-Maxillofacial Surgery, Medical University in Lódź. We enrolled 152 patients and divided them into two groups: I - study group with mandibular prognathism, II - control group without dentofacial malformations., Results: Statistical analysis revealed significant differences between the clinical size of the tongue in the study and control groups. A large tongue was more often detected in the study than the control group. The frequency of small tongue was similar in both groups., Conclusions: Patients with mandibular prognathism have a larger tongue in comparison with normal individuals.

Objective: Patients with Beckwith-Wiedemann syndrome suffer numerous anomalies, which vary somewhat from case to case. Cleft palate in combination with this syndrome has rarely been reported in the literature. Through two cases, this report examines the staging of the surgical repairs and the role of macroglossia in cleft palate and the consequences of the scarred palate on mandibular development., Results: Of four patients with Beckwith-Wiedemann syndrome, only two had a cleft palate. The timing of the repair in these two children was different. Speech development was satisfactory in the first case but mediocre in the second. This result seemed to be related to a poor social environment. Mandibular prognathism persisted in both cases., Conclusion: The treatment of patients with cleft palate and Beckwith-Wiedemann syndrome remains complex. It is preferable not to operate on a cleft palate before performing a tongue reduction plasty, but rather to combine these two surgical interventions. This would reduce the risks of anesthesia and enable the palate to heal more efficiently. Surgical treatment should be performed after the age of 6 months and before problems in speech development occur. An orthognathic surgery at adolescence could be performed if prognathism persists. While the origin of the cleft palate is still being discussed, we cannot claim that macroglossia is related to the development of cleft palate, nor that the scarred palate has an impact on the mandibular development.

Cornelia De Lange syndrome is a relatively uncommon, multiple congenital anomaly / mental retardation disorder of unknown etiology. Its incidence has been reported to vary from 1 : 30,000 to 1 : 50,000 of live births, without any known racial predilection. However, it has been considered to be due to a new dominant mutation. Main clinical features of this syndrome include growth retardation, developmental delay, hirsutism, structural limb abnormalities, mental retardation and facial growth discrepancies. Main causes of death in such patients include pneumonia along with cardiac, respiratory and GI abnormalities.