1. Association of renal damage with cardiovascular diseases is independent of individual cardiovascular risk profile in hypertension: data from the Italy - Developing Education and awareness on MicroAlbuminuria in patients with hypertensive Disease study
- Author
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Gastone Leonetti, Giuliano Tocci, Francesco Paneni, Valentina Valenti, Achille C. Pessina, Vittorio Costa, Bruno Trimarco, Ettore Ambrosioni, Sebastiano Sciarretta, Giacomo Deferrari, Massimo Volpe, Roberto Pontremoli, Enrico Agabiti Rosei, Diana Chin, Andrea Ferrucci, Sciarretta, S, Valenti, V, Tocci, G, Pontremoli, R, Rosei, Ea, Ambrosioni, E, Costa, V, Leonetti, G, Pessina, Ac, Trimarco, Bruno, Chin, D, Paneni, F, Deferrari, G, Ferrucci, A, and Volpe, M.
- Subjects
cardiovascular risk ,Adult ,Male ,medicine.medical_specialty ,Progetto Cuore ,Adolescent ,Physiology ,hypertension ,renal damage ,risk charts ,Renal function ,Young Adult ,Risk Factors ,Internal medicine ,Internal Medicine ,Medicine ,Albuminuria ,Humans ,Risk factor ,Renal Insufficiency, Chronic ,Aged ,Aged, 80 and over ,Framingham Risk Score ,business.industry ,cardiovascular risk stratification ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Surgery ,Italy ,Cardiovascular Diseases ,Hypertension ,Microalbuminuria ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Kidney disease - Abstract
OBJECTIVES: In the past years, several risk charts have been created to increase the accuracy of cardiovascular risk stratification. The most widely used and validated algorithms do not included target organ damage as risk prediction. The aim of the present study was to evaluate whether preclinical renal damage is associated with cardiovascular diseases independently of individual risk profile assessed by risk charts. METHODS: The study population was that of Italy-Developing Education and awareness on MicroAlbuminuria in patients with hypertensive Disease, a large observational study conducted on hypertensive patients in Italy. The Framingham Risk Score (FRS), Systematic COronary Risk Estimation (SCORE) and Progetto Cuore Risk Score (Progetto Cuore RS) were computed in each eligible patient. Chronic kidney disease was defined by the presence of albuminuria or by a reduction of glomerular filtration rate. RESULTS: Study participants were categorized to have low, medium and high risk according to the tertiles of the three charts. Prevalence of total cardiovascular diseases progressively and significantly increased according to the degrees of risk assessed by the three charts, the highest prevalence being in participants with a high-risk profile (both high and medium vs. low risk
- Published
- 2009