1. Efficacy and safety of standard BEACOPP regimen versus ABVD regimen for treatment of advanced Hodgkin's lymphoma.
- Author
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Lin N, He C, Zhang Q, Hong X, Liu L, Yang S, Su H, Li X, Dai X, Li Y, and Zhu J
- Subjects
- Humans, Male, Adult, Female, Middle Aged, Young Adult, Vinblastine administration & dosage, Vinblastine adverse effects, Vinblastine therapeutic use, Adolescent, Neoplasm Staging, Treatment Outcome, Hodgkin Disease drug therapy, Hodgkin Disease pathology, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bleomycin administration & dosage, Bleomycin adverse effects, Bleomycin therapeutic use, Doxorubicin administration & dosage, Doxorubicin adverse effects, Doxorubicin therapeutic use, Vincristine adverse effects, Vincristine therapeutic use, Vincristine administration & dosage, Procarbazine administration & dosage, Procarbazine adverse effects, Procarbazine therapeutic use, Cyclophosphamide administration & dosage, Cyclophosphamide adverse effects, Cyclophosphamide therapeutic use, Etoposide administration & dosage, Etoposide adverse effects, Etoposide therapeutic use, Prednisone administration & dosage, Prednisone adverse effects, Prednisone therapeutic use, Dacarbazine adverse effects, Dacarbazine administration & dosage, Dacarbazine therapeutic use
- Abstract
Introduction: The current treatment regimens for Hodgkin's lymphoma (HL) are associated with high incidences of adverse events., Purpose: This study aimed to compare the efficacy and safety of doxorubicin + bleomycin + vincristine + dacarbazine (ABVD) and standard bleomycin + etoposide + doxorubicin + cyclophosphamide + vincristine + procarbazine + prednisone (BEACOPP) chemotherapy in the treatment of advanced stage HL., Methods: This multicenter, randomized, parallel, open, positive control noninferiority trial was conducted from 2016 to 2019 and comprised 93 subjects who were randomized in a 1:1 ratio between the treatment (BEACOPP; n = 44) and control (ABVD; n = 49) groups., Results: The primary efficacy endpoint of this trial was the objective response rate (ORR) after eight cycles of chemotherapy, which was 100.00% (36/36) in the treatment group and 95.74% (45/49) in the control group. The incidence of adverse reactions was 100% in both groups. Significant differences (P < 0.05) in the incidences of grade 3 (39/44 [88.64%] vs. 23/49 [46.94%]) and grade 4 (27/44 [61.36%] vs. 8/49 [16.94%]) adverse events were observed between the treatment and control groups, respectively. However, most of these reactions were manageable, with no serious consequences, and were reversible after discontinuation of the treatment., Conclusion: Both regimens had a similar ORR and were associated with a high number of adverse events. The ABVD regimen was better tolerated and safer than the standard BEACOPP regimen. This study indicates that the standard BEACOPP regimen may be considered as a treatment option for patients with advanced HL., (Copyright © 2024 Copyright: © 2024 Journal of Cancer Research and Therapeutics.)
- Published
- 2024
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