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373 results on '"Proby, C."'

1. LB1663 A multi-gene prognostic signature associated with cutaneous squamous cell carcinoma metastasis

Author

Wang, J., primary, Harwood, C., additional, Bailey, E., additional, Bewicke-Copley, F., additional, Anene, C., additional, Thomson, J., additional, Qamar, M., additional, Nourse, C., additional, Schoenherr, C., additional, Treanor-Taylor, M., additional, Healy, E., additional, Lai, C., additional, Craig, P., additional, Moyes, C., additional, Rickaby, W., additional, Martin, J., additional, Proby, C., additional, Inman, G., additional, and Leigh, I., additional

Published
2023
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2. Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: protocol for a randomised patient-focused pilot trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma

Author

Murchie, P., Masthoff, J., Walter, F. M., Rahman, K., Allan, J. L., Burrows, N., Proby, C., Lee, A. J., Johnston, M., Durrani, A., Depasquale, I., Brant, B., Neilson, A., Meredith, F., Treweek, S., Hall, S., and McDonald, A.

Published
2019
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4. The Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial.

Author

Murchie, P, Constable, L, Hall, S, Brant, W, Allan, J, Johnston, M, Masthoff, J, Lee, A, Treweek, S, Ayansina, D, Proby, C, Rahman, K, Walter, F, Burrows, N, Durrani, A, Maclennan, G, Murchie, P, Constable, L, Hall, S, Brant, W, Allan, J, Johnston, M, Masthoff, J, Lee, A, Treweek, S, Ayansina, D, Proby, C, Rahman, K, Walter, F, Burrows, N, Durrani, A, and Maclennan, G

Abstract

BACKGROUND: Melanoma is common with increasing incidence. Guidelines recommend monthly total skin self-examinations (TSSEs) by survivors to detect recurrent and new primary melanomas. TSSE is underperformed despite evidence of benefit. OBJECTIVE: This study compares the effect on psychological well-being and TSSE practice of a self-directed digital intervention with treatment as usual in patients treated for a first stage 0 to IIC primary cutaneous melanoma within the preceding 60 months. METHODS: This randomized clinical trial was conducted at 2 UK National Health Service hospitals (Aberdeen Royal Infirmary, Grampian, and Addenbrooke's, Cambridge). Adults (≥18 years) diagnosed with a first 0 to IIC primary cutaneous melanoma were randomized to receive Achieving Self-directed Integrated Cancer Aftercare (ASICA), a tablet-based intervention prompting and supporting TSSE in survivors of melanoma, or to usual care. The hypothesis was that ASICA would increase TSSE practice in users affected by melanoma and compared with controls without affecting psychological well-being. The main primary outcomes were melanoma worry (Melanoma Worry Scale), anxiety and depression (Hospital Anxiety and Depression Scale), and quality of life (EQ-5D-5L) as well as secondary outcomes collected using postal questionnaires 3, 6, and 12 months following randomization. RESULTS: A total of 240 recruits were randomized (1:1) into the ASICA (n=121, 50.4%) or control (n=119, 49.6%) groups. There were no significant differences between groups for melanoma worry at 12 months (mean difference: 0.12, 95% CI -0.6 to 0.84; P=.74), 3 months (0.23, 95% CI -0.31 to 0.78; P=.40), or 6 months (-0.1, 95% CI -0.7 to 0.51; P=.76). The ASICA group had lower anxiety scores at 12 months (-0.54, 95% CI -1.31 to 0.230; P=.17), 3 months (-0.13, 95% CI -0.79 to 0.54; P=.71), and significantly at 6 months (-1.00, 95% CI -1.74 to -0.26; P=.009). Depression scores were similar, being lower at 12 months (-0.44, 95% CI -1.

Published
2022

5. Keratinocyte Alterations in Skin Tumour Development

Author

Leigh, I. M., Purkis, P. E., Markey, A., Collins, P., Neill, S., Proby, C., Glover, M., Lane, E. B., Herfarth, Ch., editor, Senn, H.-J., editor, Baum, M., editor, Diehl, V., editor, Gutzwiller, F., editor, Rajewsky, M. F., editor, Wannenmacher, M., editor, Hecker, Erich, editor, Jung, E. G., editor, Marks, F., editor, and Tilgen, W., editor

Published
1993
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11. Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study

Author

Bouwes Bavinck, J. N., Harwood, C. A., Genders, R. E., Wisgerhof, H. C., Plasmeijer, E. I., Mitchell, L., Olasz, E. B., Mosel, D. D., Pokorney, M. S., Serra, A. L., Feldmeyer, L., Baumann Conzett, K., Piaserico, S., Belloni Fortina, A., Jahn, K., Geusau, A., Gerritsen, M. J. P., Seçkin, D., Güleç, A. T., Cetkovská, P., Ricar, J., Imko-Walczuk, B., Proby, C. M., and Hofbauer, G. F. L.

Published
2014
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12. An updated report on the incidence and epidemiological trends of keratinocyte cancers in the United Kingdom 2013–2018

Author

Kwiatkowska, M., primary, Ahmed, S., additional, Ardern‐Jones, M., additional, Bhatti, L. A., additional, Bleiker, T. O., additional, Gavin, A., additional, Hussain, S., additional, Huws, D. W., additional, Irvine, L., additional, Langan, S. M., additional, Millington, G. W. M., additional, Mitchell, H., additional, Murphy, R., additional, Paley, L., additional, Proby, C. M., additional, Thomson, C. S., additional, Thomas, R., additional, Turner, C., additional, Vernon, S., additional, and Venables, Z. C., additional

Published
2021
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13. Achieving integrated self-directed Cancer aftercare (ASICA) for melanoma: how a digital intervention to support total skin self-examination was used by people treated for cutaneous melanoma

Author

Reilly, F, Contstable, L, Brant, W, Rahman, K, Durrani, A, Burrows, N, Proby, C, Allan, J, Johnston, M, Johnston, D, Walter, F, Murchie, P, Reilly, F, Contstable, L, Brant, W, Rahman, K, Durrani, A, Burrows, N, Proby, C, Allan, J, Johnston, M, Johnston, D, Walter, F, and Murchie, P

Abstract

BACKGROUND: Melanoma incidence has quadrupled since 1970 and melanoma is now the second most common cancer in individuals under 50. Targeted immunotherapies for melanoma now potentially enable long-term remission even in advanced melanoma, but these melanoma survivors require ongoing surveillance, with implications for NHS resources and significant social and psychological consequences for patients. Total skin self-examination (TSSE) can detect recurrence earlier and improve clinical outcomes but is underperformed in the UK. To support survivors, the Achieving Self-directed Integrated Cancer Aftercare (ASICA) intervention was developed to prompt and improve TSSE performance, with subsequent reporting of concerns and submission of skin photos to a Dermatology Nurse Practitioner (DNP). ASICA was delivered as a randomized pilot trial. METHODS: This paper reports on process evaluation. Data on participants' demographics and the concerns they reported during the trial were tabulated and displayed using Microsoft Excel and SPSS. We explored which participants used ASICA, and how frequently, to report any skin concerns. We also determined how the interactions had worked in terms of quality of skin photographs submitted, clinical assessments made by the DNP, and the assessments and decisions made for each concern. Finally, we explored significant events occurring during the trial. Data on participants' demographics and the concerns they reported during the trial were tabulated and displayed using SPSS. A semi-structured interview was undertaken with the DNP to gain perspective on the range of concerns presented and how they were resolved. RESULTS: Of 121 recruited melanoma patients receiving ASICA for 12 months, 69 participants submitted a total of 123 reports detailing 189 separate skin-related concerns and including 188 skin photographs. Where participants fully complied with follow-up by the DNP, concerns were usually resolved remotely, but 19 (10.1%) were seen at a seco

Published
2021

16. Primary Cutaneous Posttransplant Lymphoproliferative Disorders in Solid Organ Transplant Recipients: A Multicenter European Case Series

Author

Seçkin, D., Barete, S., Euvrard, S., Francès, C., Kanitakis, J., Geusau, A., del Marmol, V., Harwood, C. A., Proby, C. M., Ali, I., Güleç, A. T., Durukan, E., Lebbé, C., Alaibac, M., Laffitte, E., Cooper, S., Bavinck, Bouwes J.N., Murphy, G. M., Ferrándiz, C., Mrk, C., Cetkovská, P., Kempf, W., and Hofbauer, G. F. L.

Published
2013
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21. The patient journey: a report of skin cancer care across Europe

Author

Trakatelli, M., Siskou, S., Proby, C., Tiplica, G. S., Hinrichs, B., Altsitsiadis, E., Kitsou, A., Ferrandiz, L., Aquilina, S., Apap, C., Ulrich, M., Fiorentini, C., Magnoni, C., de Vries, E., Flohil, S. C., Kalokasidis, K., Moreno-Ramirez, D., Ruiz-de-Casas, A., Majewski, S., Ranki, A., Pitkänen, S., Saksela, O., Ioannides, D., Sotiriadis, D., and Stockfleth, E.

Published
2012
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23. Risk factors for actinic keratosis in eight European centres: a case–control study

Author

Traianou, A., Ulrich, M., Apalla, Z., De Vries, E., Bakirtzi, K., Kalabalikis, D., Ferrandiz, L., Ruiz-de-Casas, A., Moreno-Ramirez, D., Sotiriadis, D., Ioannides, D., Aquilina, S., Apap, C., Micallef, R., Scerri, L., Pitkänen, S., Saksela, O., Altsitsiadis, E., Hinrichs, B., Magnoni, C., Fiorentini, C., Majewski, S., Ranki, A., Proby, C. M., Stockfleth, E., and Trakatelli, M.

Published
2012
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25. Known and potential new risk factors for skin cancer in European populations: a multicentre case–control study

Author

de Vries, E., Trakatelli, M., Kalabalikis, D., Ferrandiz, L., Ruiz-de-Casas, A., Moreno-Ramirez, D., Sotiriadis, D., Ioannides, D., Aquilina, S., Apap, C., Micallef, R., Scerri, L., Ulrich, M., Pitkänen, S., Saksela, O., Altsitsiadis, E., Hinrichs, B., Magnoni, C., Fiorentini, C., Majewski, S., Ranki, A., Stockfleth, E., and Proby, C.

Published
2012
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36. Melanoma in Organ Transplant Recipients: Clinicopathological Features and Outcome in 100 Cases

Author

Matin, R. N., Mesher, D., Proby, C. M., McGregor, J. M., Bouwes Bavinck, J. N., del Marmol, V., Euvrard, S., Ferrandiz, C., Geusau, A., Hackethal, M., Ho, W. L., Hofbauer, G. F. L., Imko-Walczuk, B., Kanitakis, J., Lally, A., Lear, J. T., Lebbe, C., Murphy, G. M., Piaserico, S., Seckin, D., Stockfleth, E., Ulrich, C., Wojnarowska, F. T., Lin, H. Y., Balch, C., and Harwood, C. A.

Published
2008

38. Management of Kaposi sarcoma after solid organ transplantation: A European retrospective study

Author

Delyon, J., Rabate, C., Euvrard, S., Harwood, C.A., Proby, C., Gulec, T., Seckin, D., Marmol, V. del, Bouwes Bavinck, J.N., Ferrandiz-Pulido, C., Ocampo, M.A., Barete, S., Legendre, C., Frances, C., Porcher, R., Lebbe, C., Skin Care Organ Transplant Patient, Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Service Néphrologie et transplantation rénale Adultes [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Dermatologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), and Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Skin Neoplasms, mTOR inhibitor, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Antineoplastic Agents, Dermatology, chemotherapy, Organ transplantation, Tacrolimus, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Progression-free survival, Sarcoma, Kaposi, Retrospective Studies, Sirolimus, Chemotherapy, immunosuppression, business.industry, Drug Substitution, TOR Serine-Threonine Kinases, Hazard ratio, Graft Survival, Kaposi sarcoma, Retrospective cohort study, Immunosuppression, Organ Transplantation, Middle Aged, medicine.disease, 3. Good health, Calcineurin, Europe, Survival Rate, 030220 oncology & carcinogenesis, Female, Sarcoma, business, post-transplant malignancies, Immunosuppressive Agents
Abstract

Background Systemic therapeutic management of post-transplant Kaposi sarcoma (KS) is mainly based on 3 axes: reduction of immunosuppression, conversion to mammalian target of rapamycin (mTOR) inhibitors, chemotherapy, or a combination of these. Objective To obtain an overview of clinical strategies about the current treatment of KS. Methods We conducted a multicenter retrospective cohort study including 145 solid organ transplant recipients diagnosed with KS between 1985 and 2011 to collect data regarding first-line treatment and response at 6 months. Results Overall, 95%, 28%, and 16% of patients had reduction of immunosuppression, conversion to mTOR inhibitor, and chemotherapy, respectively. Patients treated with chemotherapy or mTOR inhibitor conversion were more likely to have visceral KS. At 6 months, 83% of patients had response, including 40% complete responses. Limitations The retrospective design of the study. Conclusion Currently available therapeutic options seem to be effective to control KS in most patients. Tapering down the immunosuppressive regimen remains the cornerstone of KS management.

Published
2019
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42. Outcome for post-transplant melanoma: a multi-centre European study: O-9

Author

Matin, R. N., Proby, C. M., McGregor, J. M., Bouwes-Bavinck, J. N., del Marmol, V., Euvrard, S., Ferrandiz, C., Geusau, A., Ho, W. L., Hofbauer, G., lmko, B., Lally, A., Lear, J., Lebbe, C., Murphy, G. M., Seckin, D., Stockfleth, E., Ulrich, C., Wojnarowska, F. T., and Harwood, C. A.

Published
2007

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