118 results on '"Priya Krishna"'
Search Results
2. Esophageal stenosis in head and neck cancer patients: Imaging's accuracy to predict dilation response
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Priya Krishna, Laura Bomze, Wayanne Watson, Sara Yang, Brianna Crawley, and Jared C. Inman
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cervical esophageal stenosis ,dysphagia ,esophagram ,head and neck surgery ,modified barium swallow ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Abstract Objectives The primary goal of this study was to examine how well findings of cervical esophageal stenosis on modified barium swallow (MBS) and esophagram correlate with clinical improvement following dilation in patients with a history of head and neck (H&N) cancer. Methods A retrospective review was performed at an academic hospital. The study population included H&N cancer patients with a history of neck dissection surgery who underwent esophageal dilation from 2010 to2018. Pre and postdilation swallowing function was assessed. The Functional Outcomes Swallowing Scale (FOSS) and Functional Oral Intake Scale (FOIS) were used as outcome measures. Results The 95 patients were included. All patients had imaging prior to dilation. Post‐dilation FOSS and FOIS scores were significantly improved (P
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- 2021
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3. Discovery of de novo concurrent vocal fold dysplasia in a nonagenarian man and his octogenarian wife
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Laura Bomze and Priya Krishna
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Otorhinolaryngology ,RF1-547 - Abstract
Introduction: This case report describes an unusual case of a 92-year-old man with chronic dysphonia with more recent worsening and his 88-year-old wife who developed new-onset hoarseness within 6 months of her husband's surgical treatment. Methods: Retrospective review of 2 cases. Results: Flexible laryngovideostroboscopy showed very similar exophytic hemorrhagic-appearing lesions. The pathology reports for both husband and wife were nearly identical: inflamed polypoid granulation tissue with high-grade dysplastic epithelium. No organisms were found on Periodic acid-Schiff (PAS) stain. The patients did not recall any environmental exposure in the home, dietary changes, or illnesses requiring antibiotics. Neither had prior history of vocal fold dysplasia or other vocal fold pathology. Conclusion: An elderly couple presented with nearly identical vocal fold pathology – containing polypoid granulation tissue with high-grade dysplasia. The coincidence may be related to age as a risk factor; although, shared environmental or dietary factors should be taken into consideration.
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- 2020
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4. Cephalometry as an aid in the diagnosis of pediatric obstructive sleep apnoea: A systematic review and meta-analysis
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S, Shreya, Shetty, Vabitha, Priya, Krishna, Saha, Swagata, Jaswanth, Jyotsna, and Sethi, Sneha
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- 2024
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5. Recent advances in edible coating of food products and its legislations: A review
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Priya, Krishna, Thirunavookarasu, Nirmal, and Chidanand, D.V.
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- 2023
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6. Bioinformatics tools associated with isolation and identification of marine endosymbiontic fungi
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Priya, Krishna R and Kumar, Anil V G
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- 2022
7. COVID-19 and precarious housing: paying guest accommodation in a metropolitan Indian city
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Marella, Sai Rama Raju, Priya, Krishna, and Vincia D'Souza, Pooja
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- 2022
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8. Case Report: Holistic dental care for a child with hunter syndrome: Addressing dental ramifications, overcoming challenges, and enhancing quality of life
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Saha, Swagata, primary, Priya, Krishna, additional, Rai, Kavita, additional, R, Manju, additional, Shetty, Krithika, additional, M Hegde, Amitha, additional, Rao K, Ananya, additional, Abhijit Tanna, Dhavni, additional, S, Mohanaram, additional, and S, Shreya, additional
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- 2024
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9. Unmasking the Features of the Pandemic Through Malayalam Cinema: A Study of Sanu John Varghese’s Aarkkariyam and Dileesh Pothan’s Joji.
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Priya, Krishna and Vishwanathan, M. Raja
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COVID-19 pandemic ,MALAYALAM language ,MOTION pictures ,IDIOMS ,EMOTIONAL trauma - Abstract
The pandemic provides an opportunity for filmmakers to identify the potential of the limited space. The pandemic-driven perspectives of the filmmakers widen the horizon of space beyond the spatial and temporal dimensions. Malayalam films have responded to the unprecedented and shocking outbreak of COVID-19 faster because space and its utilization have been always minimal in the industry. People have been shattered in isolation and the new normal imparted new phrases and idioms to the language of life. The desire to socialize, the angst to stay and work at home, the issues of parenting, and the financial crisis have all become part of the new normal. To narrate any kind of story has appeared challenging because the pandemic is an amalgamation of anxieties and it demands to be faithful to all the unfortunate situations of life while featuring it. Thus, the idea of shifting from the physical space to the psychological space progressed and it paves way for extraordinary films with brilliant performances. This paper is an attempt to explore the documentation of the pandemic in Aarkkariyam, a 2021 mystery drama and Joji, a crime thriller. The paper focuses on the many facets of the pandemic like psychological trauma, isolation, work from home, social and financial instability, and the change in the dynamics of ‘home’. [ABSTRACT FROM AUTHOR]
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- 2024
10. THE COMBINATION OF NATURAL AND SYNTHETIC POLYMERS FOR EFFECTIVE WOUND HEALING IN TISSUE ENGINEERING.
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Aparna, T., Priya, Krishna, Santhosh, M., and Nagarajan, Shankar
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WOUND healing ,TISSUE engineering ,PLANTAIN banana ,TISSUE wounds ,POLYETHYLENE glycol ,BIOPOLYMERS - Abstract
Burns range in severity depending on the amount of area they cover on the body and how deeply they penetrate the skin and tissue beneath. Wound healing is an intricate and orchestrated process involving the interactions of various cell components to establish a provisional tissue and then remodel this while forming the mature replacement. Many types of polymers have been used for wound healing till date, which had benefits and disadvantages associated with it. The work here concerns towards effective wound healing process by employing the use of Musa paradisiaca Linn. commonly known as Banana, which had been used traditionally in India for dressings of wound and ulcers. The appropriate combination of the M. paradisiaca leaves and stem, along with the synthetic polymer, Polyethylene glycol was used, since it possess the properties of being biocompatible, in addition to being a good antimicrobial agent along with antioxidant properties. Characterization of the materials using FTIR provides the congruence of the presence of components that assist in effective wound healing. [ABSTRACT FROM AUTHOR]
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- 2024
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11. The diagnostic workup of patients with a primary complaint of post-nasal drip
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Hector A. Perez, Nadia Chan, Brianna Crawley, Priya Krishna, Christopher A. Church, and Kristin A. Seiberling
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General Engineering - Abstract
Background: Post-nasal drip (PND) is likely multifactorial in etiology which may be attributed to excessive sinonasal secretions or an increase in mucous viscosity from chronic sinusitis or allergic rhinitis. Increased throat sensitivity due to inflammatory changes have been postulated as a possible cause, which may be secondary to laryngopharyngeal reflux (LPR). Methods: Patients presenting with a primary complaint of post-nasal drip were prospectively enrolled into the cohort study. All patients underwent nasal endoscopy, flexible laryngoscopy, in-vitro allergy testing, and computed tomography (CT) imaging. Patients were also asked to fill out a SNOT-22 questionnaire and a reflux severity index (RSI) form. Results: 33 patients were enrolled in the study of which 22 completed all necessary procedures. In our cohort of patients the average SNOT score was 43±22, and the average RSI was 22±7. Twenty-one of the 22 patients had RSIs consistent with LPR. Reflux finding scores (RFS) as evaluated and averaged between two laryngologists found that all patients in the cohort met criteria for LPR with an average RFS of 12.6±2.1. Fourteen of the 22 patients had a positive RAST. Seventeen of the patients in the cohort had CT scans that were normal. The average Lund Kennedy score was 0.9±1.4 with 14 of the 22 patients having unremarkable nasal endoscopies. Conclusions: Patients with PND benefit from consideration of empiric treatment with PPIs, dietary modification given the high rates of LPR. Consideration should also be given to allergy testing prior to any consideration for CT imaging.
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- 2023
12. Lessons for Social Protection from the COVID-19 Lockdowns Report 2 of 2: Non-State Actors
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Bhan, Gautam, primary, DSouza, Pooja, additional, Gajjar, Harshal, additional, Margosa, Neha, additional, Mehra, Rashee, additional, Priya, Krishna, additional, and Sai Rashmi, Chimmiri, additional
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- 2022
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13. Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated protection against tumor growth in a murine model of triple-negative breast cancer
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Laura C. D. Pomatto-Watson, Monica Bodogai, Melissa Carpenter, Dolly Chowdhury, Priya Krishna, Sandy Ng, Oye Bosompra, Jonathan Kato, Sarah Wong, Carlos Reyes-Sepulveda, Michel Bernier, Nathan L. Price, Arya Biragyn, and Rafael de Cabo
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Mice ,Disease Models, Animal ,Aging ,Myeloid-Derived Suppressor Cells ,Cell Line, Tumor ,Humans ,Animals ,Original Article ,Female ,Triple Negative Breast Neoplasms ,Geriatrics and Gerontology ,Caloric Restriction - Abstract
Caloric restriction (CR) is the leading non-pharmacological intervention to delay induced and spontaneous tumors in pre-clinical models. These effects of CR are largely attributed to canonical inhibition of pro-growth pathways. However, our recent data suggest that CR impairs primary tumor growth and cancer progression in the murine 4T1 model of triple negative breast cancer (TNBC), at least in part, through reduced frequency of the myeloid-derived suppressor cells (MDSC). In the present study, we sought to determine whether injection of excess MDSCs could block regression in 4T1 tumor growth and metastatic spread in BALB/cJ female mice undergoing daily CR. Our findings show that MDSC injection impeded CR-mediated protection against tumor growth without increasing lung metastatic burden. Overall, these results reveal that CR can slow cancer progression by affecting immune suppressive cells. Impact statement: Inoculation of MDSCs from donor mice effectively impedes the ability of calorie restriction to protect against primary tumor growth without impacting lung metastatic burden in recipient animals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-022-00635-y.
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- 2022
14. Designing a Resident Led Otolaryngology Clinic at a Community Health Center: An Initial Experience
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Ethan Frank, Christopher Vuong, Nathan H Lee, Shannon O Fujimoto, Khanh Nguyen, Priya Krishna, and Daniel I Kwon
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Objectives: To report a resident-led otolaryngology clinic experience at an independent Federally Qualified Health Center (FQHC) with an affiliated academic center. We compared delivery of subspecialty care for underserved patients in a unique resident run clinic to standard care at the university staffed subspecialty clinics. Methods: Retrospective cohort study of surgical patients seen at the Social Action Community Health System (SACHS) otolaryngology clinic over a one-year period compared with a matched control cohort of patients having similar procedures at the affiliated faculty academic practice. Measured endpoints were case type, time of referral to consultation, time interval between surgical decision and date of surgery, surgical complications, as well as post-surgical follow up. Results: A total of 687 new patients were seen at SACHS clinic, with approximately 18% ultimately undergoing surgery. All otolaryngology sub-specialties were represented including otology, facial plastics, and head and neck oncology. SACHS patients had overall slightly higher median interval times from referral to consultation and from surgical decision to date of surgery though this did not reach significance. There were no differences in surgical outcomes or complication rates between the SACHS cohort and faculty cohort. Conclusions: We demonstrate a mutually beneficial partnership between a fully resourced FQHC system and an otolaryngology residency program to provide reciprocally beneficial training experience and effective health care delivery.
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- 2023
15. The Diagnosis and Time of Onset of Voice Disorders in Patients with Chronic Cough
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Jessica F. Kim, WayAnne Watson, Benjamin J. Becerra, Brianna K. Crawley, Rim Saab, Priya Krishna, and Thomas Murry
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Speech and Hearing ,Otorhinolaryngology ,LPN and LVN - Published
- 2022
16. Esophageal stenosis in head and neck cancer patients: Imaging's accuracy to predict dilation response
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Sara Yang, Priya Krishna, WayAnne Watson, Laura Bomze, Jared C. Inman, and Brianna K. Crawley
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medicine.medical_specialty ,RD1-811 ,dysphagia ,medicine.medical_treatment ,head and neck surgery ,Dilation (metric space) ,Swallowing ,Medicine ,cervical esophageal stenosis ,Original Research ,business.industry ,Esophagram ,Head and neck cancer ,esophagram ,Cancer ,Neck dissection ,General Medicine ,medicine.disease ,Dysphagia ,Stenosis ,Otorhinolaryngology ,RF1-547 ,Surgery ,Radiology ,modified barium swallow ,HEAD AND NECK, AND TUMOR BIOLOGY ,medicine.symptom ,business - Abstract
Objectives The primary goal of this study was to examine how well findings of cervical esophageal stenosis on modified barium swallow (MBS) and esophagram correlate with clinical improvement following dilation in patients with a history of head and neck (H&N) cancer. Methods A retrospective review was performed at an academic hospital. The study population included H&N cancer patients with a history of neck dissection surgery who underwent esophageal dilation from 2010 to2018. Pre and postdilation swallowing function was assessed. The Functional Outcomes Swallowing Scale (FOSS) and Functional Oral Intake Scale (FOIS) were used as outcome measures. Results The 95 patients were included. All patients had imaging prior to dilation. Post‐dilation FOSS and FOIS scores were significantly improved (P, The aim of this study was to determine the ability of the modified barium swallow (MBS) and esophagram to accurately predict cervical esophageal stenosis in patients with history of head and neck cancer that would benefit from esophageal dilation. A retrospective review was performed at an academic hospital of patients who had previous neck dissection surgery for cancer and underwent esophageal dilation from 2010‐2018. These imaging studies appear to have mixed reliability as predictors of response to esophageal dilation in this population that is high risk for cervical esophageal stenosis.
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- 2021
17. A STUDY TO ASSESS THE KNOWLEDGE REGARDING PREVENTION AND HOME MANAGEMENT OF DIARRHEAL DISEASE AMONG MOTHER OF UNDER FIVE CHILDREN AT PEDIATRIC OPD IN NMCH, ROHTAK, BIHAR.
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Priya, Krishna, primary, Kumari, Ankita, additional, Kumari, Shobha, additional, and Singh, Sapna, additional
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- 2022
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18. Biosynthesis and Response of Zinc Oxide Nanoparticles against Periimplantitis Triggering Pathogens
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Ting, Bernice Yii Shu, primary, Fuloria, Neeraj Kumar, additional, Subrimanyan, Vetriselvan, additional, Bajaj, Sakshi, additional, Chinni, Suresh V., additional, Reddy, Lebaka Veeranjaneya, additional, Sathasivam, Kathiresan V., additional, Karupiah, Sundram, additional, Malviya, Rishabha, additional, Meenakshi, Dhanalekshmi Unnikrishnan, additional, Paliwal, Neeraj, additional, Priya, Krishna, additional, and Fuloria, Shivkanya, additional
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- 2022
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19. Tobacco Cessation Counseling among Oral Healthcare Professionals in Tricity
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Gupta, Nidhi, primary, Gupta, Preeti, additional, Sharma, Aditi, additional, Verma, Vikas, additional, and Priya, Krishna, additional
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- 2022
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20. Expiratory Muscle Strength Treatment for Refractory Chronic Cough: A Short-term Single Exercise Program
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Kassandra Quibin, Brianna K. Crawley, Rim Saab, Priya Krishna, and Thomas Murry
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Speech and Hearing ,Otorhinolaryngology ,LPN and LVN - Abstract
Patients with chronic cough are some of the most challenging to treat. This preliminary study is the first to examine the effects of a single exercise muscle strength training program to reduce cough severity in patients who failed other treatments.A total of 19 females were included in this study, ranging from age 24 to 80. The maximum phonation time (MPT), laryngeal airway resistance (LAR), maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP), Voice Handicap Index-10, (VHI-10) and the Cough Severity Index (CSI) values were obtained pre- and post-treatment. ANOVA two-factor without replication was used to compare values pre- and post-treatment.MIP (Mean of 62.00 to a mean of 78.53) and MEP (Mean of 90.00 to a mean of 112.16) showed significant increase post-treatment. In addition, LAR (Mean of 73.30 to a mean of 60.67) and CSI (Mean of 19.37 to a mean of 15.00) significantly decreased post-treatment. General changes in pre- and post-treatment values were identified with MPT (Mean of 14.89 to a mean of 16.17) and VHI-10 (Mean of 8.00 to a mean of 6.76). A follow-up questionnaire indicated that the majority of patients felt their cough was better after 4 weeks.Muscle strength training provides a tool to aid in the control of cough for patients who are refractory to medical and other behavioral treatments. Improvement in cough may be associated with a reduction in subglottic pressure and increased air flow resulting in lower laryngeal airway resistance.
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- 2022
21. List of contributors
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Mohd Azmuddin Abdullah, Charles Oluwaseun Adetunji, Mohd Imran Ahamed, Muhammad Sajid Hamid Akash, Sadia Akram, Sana Ali, Telli Alia, Mafalda R. Almeida, Fereshteh S. Amani, Osikemekha Anthony Anani, Sherly Antony, S. Anuradha, Naushad Anwar, Marília T. Araújo, K.B. Arun, Pramod K. Avti, Hamidreza Bagheri, Shiv Bahadur, Bubun Banerjee, Syqa Banoo, Andreea Irina Barzic, Masrat Bashir, K. Bhanu Revathi, Parameswaran Binod, Arunima Biswas, Arushi Chauhan, Arun chelliah, Bruna Galdorfini Chiari-Andréo, Glauber Cruz, Julie Brenda Santos da Silva, Ankita Das, Alessandra Teixeira de Macedo, Felipe M. de Souza, Maria Eliziane Pires de Souza, Biswajit Debnath, Sunita Devi, Vividha Dhapte-Pawar, Surender Duhan, Apurba Dutta, Shibitha Emmanual, Mara G. Freire, Isadora Frigieri, Anirban Garg, Saswati Gharami, Sib Sankar Giri, Ram K. Gupta, Rodrigo Assunção Holanda, Hanaa Ali Hussein, Shah Imtiaz, Tenzin Ingsel, Abel Inobeme, S.K. Manirul Islam, Manojkumar Jadhao, Christine Jeyaseelan, Racheal John, Ritika Joshi, Qari Muhammad Kaleem, Gurpreet Kaur, Satish Khasa, Priya Krishna, Atul Kumar, Krishnamoorthy Lalitha, Aravind Madhavan, Flávia F. Magalhães, D. Manikandan, Laura Arruda Mascaro, G. Meghana, Piyush Pradeep Mehta, S.U. Mohammed Riyaz, Ali Mohebbi, Mina Naderi, Sumaira Naeem, Subbiah Nagarajan, Jawayria Najeeb, Nayra Najeeb, S. Nalini, João C.F. Nunes, Olugbemi Tope Olaniyan, Julius Kola Oloke, Wadzani Dauda Palnam, Aarati Panchbhai, Ashok Pandey, Se Chang Park, S. Parveen, Kamla Pathak, Satyanarayan Pattnaik, Waqar Pervaiz, Anu Priya, Apoorv Rana, Prasanth Rathinam, Kanwal Rehman, Reshmy R., Adones Almeida Rocha, Amrita Saha, Awotunde Oluwasegun Samson, Namrata Sangwan, Audirene Amorim Santana, Julliana Ribeiro Alves dos Santos, B. Saravanakumar, Moumita Sardar, Solanki Sarkar, Diganta Sarma, S. Sathiyamurthi, Karishma Shetty, K. Shinomol George, Raveendran Sindhu, Vandana Singh, T. Stalin Dhas, T.U. Sukumaran, Kalpana Swain, Deborah Sybil, Ana P.M. Tavares, Sheikh Muhammad Usman, Rualdo Valderrama Filho, Vadanasundari Vedarethinam, Francis Victor, Shreya Walvekar, Khushwant S. Yadav, Soma Yasaswi, and Amanda Karina de Paula Zago
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- 2022
22. Biosurfactants for pharmacological interventions in cancer therapy
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K.B. Arun, Shibitha Emmanual, Priya Krishna, Aravind Madhavan, Parameswaran Binod, Ashok Pandey, and Raveendran Sindhu
- Published
- 2022
23. Recent Laryngology Fellowship Graduates: Where Are They Now?
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Thomas Murry, Michael M. Johns, Benjamin Damazo, Brianna K. Crawley, Salem Dehom, Victoria Cress, Traci Bailey, Priya Krishna, and Daniel R. Fisher
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Male ,Medical education ,medicine.medical_specialty ,Academic Medical Centers ,Laryngology ,business.industry ,Academic practice ,Internship and Residency ,General Medicine ,United States ,Otolaryngology ,Cross-Sectional Studies ,Otorhinolaryngology ,Education, Medical, Graduate ,Surveys and Questionnaires ,medicine ,Humans ,Female ,Fellowships and Scholarships ,business ,Fellowship training - Abstract
Objectives: Over the past 30 years laryngology fellowships have grown in number and diversity. This study investigated the career trajectories of recent laryngology fellowship graduates with the purpose of informing residents considering fellowship. Study design: Cross-sectional survey Setting: Academic medical center Methods: The directors of all 27 US laryngology fellowships that graduated/recruited fellows from 2010 to 2019 were contacted, and a list of former fellows was compiled. A short survey was administered in person or via email or phone. Additional data was gathered through internet searches. Results: One hundred eighty-three fellows were identified having completed American laryngology fellowships between 2010 and 2019 (100M:83F). Fifteen percent now practice internationally and 68% are in academic practice. A higher proportion of women than men enter laryngology fellowship after otolaryngology residency. One hundred twenty-nine fellows responded to our survey. Two-thirds of former fellows report current participation in laryngology research. Seventy-two percent of former fellows are still in their first job after fellowship and 53% believe they have their ideal practice. Women were more likely to enter academics than men after laryngology fellowship. Responders were overwhelmingly satisfied with their fellowship experience, with 95% saying they would choose to pursue fellowship training again. Conclusions: Most former laryngology fellows enter academia, contribute to laryngology research, practice away from their training institution, and believe they have found their ideal practice. The results of this study may be useful to residents considering fellowship training, centers considering establishing laryngology fellowships, and practices recruiting fellowship graduates.
- Published
- 2021
24. Feto-placental Changes in Pregnancy Induced Hypertension
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Sulochana, Sonti, primary, Priya, Krishna, primary, and Sindhuja, ., primary
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- 2021
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25. Effects of Cough Suppression Therapy on Voice Disorder Severity
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Brianna K. Crawley, Donn LaTour, Priya Krishna, Thomas Murry, and Rachel Hahn
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Adult ,Male ,medicine.medical_specialty ,Group based ,Voice Quality ,Breathing Exercises ,Severity of Illness Index ,Voice Disorder ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Refractory ,Internal medicine ,medicine ,Humans ,In patient ,030223 otorhinolaryngology ,Aged ,Retrospective Studies ,Aged, 80 and over ,Voice Disorders ,Medical treatment ,business.industry ,Middle Aged ,respiratory tract diseases ,Chronic cough ,Cough suppression ,Treatment Outcome ,030228 respiratory system ,Otorhinolaryngology ,Cough ,Chronic Disease ,Voice handicap ,Female ,medicine.symptom ,business - Abstract
OBJECTIVES//HYPOTHESIS To determine changes in voice severity when treating chronic cough refractory to medical treatment with cough suppression therapy (CST) in patients with chronic cough and voice complaints. Chronic cough has been reported to be refractory to medical treatment and frequently co-occurs with voice disorders. The possible effects of CST on self-assessed changes in chronic cough and voice disorders have not been demonstrated. STUDY DESIGN Retrospective analysis of the effects of cough suppression therapy (CST) on self-assessed changes in chronic cough and voice disorder severity in patients with both chronic cough and voice disorders. METHODS Forty-three adult patients with the primary complaint of chronic refractory cough underwent pre- and post-treatment diagnostic examinations, completed pre- and post-treatment Voice Handicap Index-10 (VHI-10) and Cough Severity Index assessments, and were treated by a licensed speech-language pathologist using CST. Twenty-seven subjects were assigned to the cough (C) group and 16 to the cough-voice (CV) group based on the severity of their VHI-10 scores. RESULTS Post-test analysis showed significant improvement in cough severity for both groups and significant improvement in voice severity for the CV group. The VHI-10 scores for the C group did not change significantly. The median number of treatment sessions was 3, with a range of 1-13 sessions. Correlation between changes in severity and number of treatment sessions was not found to be significant at the tested level. CONCLUSIONS CST represents a unifying approach for treatment of patients with CRC and comorbid voice disorders. CST offered cross-over effects to the voice when subjects were treated for their primary complaint of chronic cough. This treatment of the primary complaint improves function in systems that share a common pathway. LEVEL OF EVIDENCE 4 Laryngoscope, 131:2747-2751, 2021.
- Published
- 2021
26. A case of vasculitis, retinitis and macular neurosensory detachment presenting post typhoid fever
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Relhan, Nidhi, Pathengay, Avinash, Albini, Thomas, Priya, Krishna, Jalali, Subhadra, and Flynn, Harry W
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- 2014
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27. Endoscopic management of high-grade biliary strictures complicating living donor liver transplantation using soehendra stent retrievers
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Rao, Harshavardhan B., primary, Koshy, Anoop K., additional, Priya, Krishna, additional, Nair, Priya, additional, Sudhindran, S., additional, and Venu, Rama P., additional
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- 2021
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28. Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition
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Alberto Diaz-Ruiz, Dolly Chowdhury, Eleonora Duregon, Oye Bosompra, Nathan L. Price, Paula Gonzalez Ericsson, Rafael de Cabo, Jonathan Kato, Arya Biragyn, Sandy Ng, Melissa Carpenter, Roberto Salgado, Michel Bernier, Monica Bodogai, Emeline Ragonnaud, Valter D. Longo, Sarah Wong, Laura C. D. Pomatto-Watson, and Priya Krishna
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Calorie ,Lung Neoplasms ,Cancer therapy ,Science ,General Physics and Astronomy ,Physiology ,medicine.disease_cause ,General Biochemistry, Genetics and Molecular Biology ,Article ,Metastasis ,Mice ,Breast cancer ,Cell Line, Tumor ,medicine ,Tumor Microenvironment ,Animals ,Cause of death ,Caloric Restriction ,Multidisciplinary ,business.industry ,Cancer ,Caloric theory ,Mammary Neoplasms, Experimental ,General Chemistry ,Fasting ,medicine.disease ,Primary tumor ,Tumor Burden ,Female ,business ,Carcinogenesis - Abstract
Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. However, due to CR’s stringency, dietary alternatives offering the same cancer protection have become increasingly attractive. Short cycles of a plant-based diet designed to mimic fasting (FMD) are protective against tumorigenesis without the chronic restriction of calories. Yet, it is unclear whether the fasting time, level of dietary restriction, or nutrient composition is the primary driver behind cancer protection. Using a breast cancer model in mice, we compare the potency of daily CR to that of periodic caloric cycling on FMD or an isocaloric standard laboratory chow against primary tumor growth and metastatic burden. Here, we report that daily CR provides greater protection against tumor growth and metastasis to the lung, which may be in part due to the unique immune signature observed with daily CR., Caloric restriction (CR) has been shown as an effective intervention to reduce tumorigenesis, but alternative less stringent dietary interventions have also been considered. Here, the authors show that in a murine model of breast cancer CR has a larger effect on preventing tumorigenesis and metastasis compared to periodic caloric cycling.
- Published
- 2021
29. Selection of Appropriate Growth Model for Prediction of Sugarcane Area, Production and Productivity of India
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Bajpai, P. K., Priya, Krishna, and Malik, Meenakshee
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- 2012
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30. Safer Singing During the SARS-CoV-2 Pandemic: What We Know and What We Don't
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David Meyer, Michael M. Johns, Adam D. Rubin, Aaron M. Johnson, Robert T. Sataloff, Jonathan M. Bock, Herbert Steven Sims, Matthew R. Naunheim, Philip A. Doucette, Ian Howell, Trineice Robinson-Martin, Priya Krishna, Matthew Hoch, Claudio F. Milstein, Michael J. Pitman, John Nix, Ingo R. Titze, and Thomas L. Carroll
- Subjects
business.industry ,Distancing ,SARS-CoV-2 ,Best practice ,coronavirus ,Globe ,COVID-19 ,Singing ,Public relations ,LPN and LVN ,Article ,choral performance ,Speech and Hearing ,medicine.anatomical_structure ,Otorhinolaryngology ,SAFER ,Health care ,medicine ,Choir ,Humans ,Psychology ,business ,Personal protective equipment ,Pandemics - Abstract
While the novel coronavirus outbreak has profoundly altered health care systems across the globe, it has also affected similar change and devastation on the social, educational, and cultural communities upon which many rely, including communities of choral singers, solo performers, conductors, voice teachers, and the professionals that collaborate with them. Even as citizens of the most heavily impacted countries took to their balconies to serenade first responders and health care workers, singers of most genres who typically perform in ensembles have been told to not carry on their beloved practice. This message, promoted by the lay media and by early reports of “super-spreading” of the virus at choral events in the United States and abroad,1 , 2 has been reinforced by expert and nonexpert opinion regarding the transmissibility of SARS-CoV-2 through droplets and aerosols, the generation of respiratory particles when singing, and concern about the interpersonal interactions that routinely accompany vocal performance, both in groups and in one-on-one teaching situations. Unfortunately, there is a paucity of data about both how SARS-CoV-2 is transmitted by singing and how to bring communities of singers back together safely. The data available about disease spread through vocalization, most of which preceded the current pandemic, address primarily transmission of disease through droplets and aerosols and are specific neither to this virus nor to singing.3, 4, 5, 6 Specifically, there is a lack of data addressing how to congregate and sing safely in choral environments such as churches, concert halls and practice spaces, as well as stages, theatres and other venues. In addition, protective measures such as safest distancing between singers, wearing masks or other personal protective equipment (PPE), using larger rehearsal or performance spaces, reducing the number of singers inside a certain enclosed space, reducing the duration of rehearsals or performances, and using real time air and surface cleaning methods such as increased ventilation, UV-C light and HEPA filtration specific to a singing environment among other topics have not been studied well enough to provide evidence on which to base advice to the singing community. Opinion on these matters is plentiful and often divergent. A recent webinar with a panel of experts in the world of voice care and singing left the audience with the message, “There is no safe way for singers to rehearse together until there is a COVID-19 vaccine and a 95% effective treatment in place.”7 , 8 Although, this may ultimately prove to be accurate, evidence-based practice (defined as an approach to health that integrates scientific research, patient preferences and values, and clinical expertise to make the best recommendations possible) does not allow for such a definitive conclusion to be made at this time.9 It must be understood, that these recommendations and decisions are made not only on what scientific information is available but on intuition and unsystematic experience that is often biased and inaccurate. We do not understand all the risks posed by COVID 19 to ourselves, friends, family and colleagues, who wish to resume educational, performance, communal and congregational singing safely. Evidence-based practice demands that we critically evaluate our current state of knowledge to come up with the best possible information to disseminate. In this article, we review the information that exists relating to singing and COVID-19. This paper is intended to provide guidance based on what we know: the best available data, analyzed and scrutinized by a panel of experts in the medical, behavioral and basic science world of voice care, of whom many are professional singers, choir directors or teachers of singing. While it may not be able to afford any definitive answers, this work will offer suggestions of best practices for those singing groups that are willing to mitigate risk knowing that the risk cannot be brought to zero. Finally, this report will hopefully stimulate the larger voice research community to study the emerging consensus on safe resumption of singing and pursue scientific understanding of COVID-19.
- Published
- 2020
31. Combined Parietal-Insular-Striatal Cortex Stroke with New-Onset Hallucinations: Supporting the Salience Network Model of Schizophrenia
- Author
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Nanda, Saheba, Priya, Krishna, Khan, Tasmia, Patel, Puja, Azizi, Heela, Nuthalapati, Deepa, Paul, Christen, Sippy, Rabina, Simsam, Abdulkader Hmidan, Abraham, Jesslin, Singh, Gurjinder, Goodarzi, Alireza, Ojimba, Chiedozie, and Jolayemi, Ayodeji
- Subjects
nervous system ,Article Subject - Abstract
Brain imaging studies have identified multiple neuronal networks and circuits in the brain with altered functioning in patients with schizophrenia. These include the hippocampo-cerebello-cortical circuit, the prefrontal-thalamic-cerebellar circuit, functional integration in the bilateral caudate nucleus, and the salience network consisting of the insular cortex, parietal anterior cingulate cortex, and striatum, as well as limbic structures. Attributing psychotic symptoms to any of these networks in schizophrenia is confounded by the disruption of these networks in schizophrenic patients. Such attribution can be done with isolated dysfunction in any of these networks with concurrent psychotic symptoms. We present the case of a patient who presents with new-onset hallucinations and a stroke in brain regions similar to the salience network (insular cortex, parietal cortex, and striatum). The implication of these findings in isolating psychotic symptoms of the salience network is discussed.
- Published
- 2020
- Full Text
- View/download PDF
32. Perception and duration of pain after office-based vocal fold injection augmentation
- Author
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Priya Krishna, Justin Hata, Salem Dehom, Thomas Murry, Emily Kutzner, and Brianna K. Crawley
- Subjects
medicine.medical_specialty ,Laryngology ,business.industry ,Visual analogue scale ,Sedation ,Vital signs ,03 medical and health sciences ,0302 clinical medicine ,Otorhinolaryngology ,Swallowing ,McGill Pain Questionnaire ,Heart rate ,medicine ,Physical therapy ,medicine.symptom ,030223 otorhinolaryngology ,business ,Prospective cohort study ,030217 neurology & neurosurgery - Abstract
Objectives/hypothesis In-office laryngology procedures are important in the treatment of voice and swallowing disorders. Patient tolerance determines which procedures can be performed without sedation or formal anesthesia. This study examines pain perception during and after in-office vocal fold injection augmentation. Study design Prospective cohort study. Methods Patients scheduled for office-based vocal fold injection augmentation were prospectively enrolled at an academic voice center. The short-form McGill Pain Questionnaire was administered before, during, and after the procedure and on postprocedure days 1, 3, and 7. Pre- and postprocedure vital signs were recorded and heart rate was continuously monitored. Telephone questionnaires were completed on postprocedure days 1 and 3. Results Forty-five patients consented to participate in our study (24 males, mean age 61 years). Most patients experienced mild to moderate pain with increasing heart rate during the procedure. Pain remained or increased 20 minutes after the procedure and improved but persisted for 1 day. Sensory and affective discomfort was endorsed by the majority. A minority of patients experienced bruising and changes in swallowing with diet modification for 3 days after the procedure. Sixteen percent had discomfort after 1 week. Conclusions This is the first prospective study examining patient perception of pain during and after in-office injection augmentation using a validated scale and pain descriptors with extended follow-up. The results may offer guidance for patient counseling, consent, and treatment to improve tolerance and success. Level of evidence 4. Laryngoscope, 128:929-934, 2018.
- Published
- 2018
33. Esophagram findings in cervical esophageal stenosis: A case-controlled quantitative analysis
- Author
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Brianna K. Crawley, Jacob A. West, Zachary Reichert, Jared C. Inman, Priya Krishna, and Cherine H. Kim
- Subjects
medicine.medical_specialty ,Receiver operating characteristic analysis ,Esophagram ,business.industry ,medicine.disease ,Dysphagia ,03 medical and health sciences ,Stenosis ,0302 clinical medicine ,Otorhinolaryngology ,Swallowing ,Esophageal stenosis ,030220 oncology & carcinogenesis ,medicine ,Lower border ,030211 gastroenterology & hepatology ,Radiology ,medicine.symptom ,business ,Body mass index - Abstract
OBJECTIVE Cervical esophageal stenosis is often diagnosed with a qualitative evaluation of a barium esophagram. Although the esophagram is frequently the initial screening exam for dysphagia, a clear objective standard for stenosis has not been defined. In this study, we measured esophagram diameters in order to establish a quantitative standard for defining cervical esophageal stenosis that requires surgical intervention. STUDY DESIGN Single institution case-control study. METHODS Patients with clinically significant cervical esophageal stenosis defined by moderate symptoms of dysphagia (Functional Outcome Swallowing Scale > 2 and Functional Oral Intake Scale
- Published
- 2018
34. Treating laryngopharyngeal reflux: Evaluation of an anti-reflux program with comparison to medications
- Author
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Thomas Murry, Jin Yang, Priya Krishna, Salem Dehom, Stephanie Sanders, and Brianna K. Crawley
- Subjects
Adult ,Male ,medicine.medical_specialty ,Databases, Factual ,Laryngoscopy ,Alkaline water ,Risk Assessment ,Severity of Illness Index ,Tertiary care ,California ,Cohort Studies ,03 medical and health sciences ,Subjective improvement ,Laryngopharyngeal reflux ,0302 clinical medicine ,Internal medicine ,Laryngopharyngeal Reflux ,medicine ,Humans ,Voice Handicap Index ,030223 otorhinolaryngology ,Aged ,Retrospective Studies ,Academic Medical Centers ,Cognitive Behavioral Therapy ,medicine.diagnostic_test ,business.industry ,Reflux ,Proton Pump Inhibitors ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Combined Modality Therapy ,Treatment Outcome ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Quality of Life ,Physical therapy ,Female ,business ,Diet Therapy - Abstract
Objective To determine if an anti-reflux induction program relieves laryngopharyngeal reflux (LPR) symptoms more effectively than medication and behavioral changes alone. Study design Retrospective study. Setting Tertiary care academic center. Subjects and methods A database was populated with patients treated for LPR. Patients were included in the study group if they completed a two-week anti-reflux program (diet, alkaline water, medications, behavioral modifications). Patients were included in the control group if they completed anti-reflux medications and behavioral modifications only. Patients completed the voice handicap index (VHI), reflux symptom index (RSI), cough severity index (CSI), dyspnea index (DI) and eating assessment tool (EAT-10) surveys and underwent laryngoscopy for examination and reflux finding score (RFS) quantification. Results Of 105 study group patients, 96 (91%) reported subjective improvement in their LPR symptoms after an average 32-day first follow-up and their RSI and CSI scores improved significantly. No significant differences were found in VHI, DI, or EAT-10 scores. Fifteen study patients who had previously failed adequate high-dose medication trials reported improvement and their CSI and EAT-10 scores improved significantly. Ninety-five percent of patients with a chief complaint of cough reported improvement and their CSI scores improved significantly from 12.3 to 8.2. Among 81 controls, only 39 (48%) patients reported improvement after an average 62-day first follow-up. Their RSI scores did not significantly change. Conclusion The anti-reflux program yielded rapid and substantial results for a large cohort of patients with LPR. It compared favorably with medication and behavioral modification alone. It was effective in improving cough and treating patients who had previously failed medications alone.
- Published
- 2018
35. The future is not just a 6-minute walk test
- Author
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Amirtha Priya Krishna, Caitlin Lee, and Mahmood Ahmad
- Subjects
medicine.medical_specialty ,Physical medicine and rehabilitation ,business.industry ,Medicine ,6-minute walk test ,business - Published
- 2021
36. Thrombosis of Both Umbilical Arteries of a Female Fetus in a Twin Gestation Causing Fetal Demise
- Author
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Bhat, Shubha P., additional, Paul, Riturupa, additional, Srinivas, Teerthanath, additional, Sonkusare, Shipra, additional, and Priya, Krishna, additional
- Published
- 2020
- Full Text
- View/download PDF
37. Cooking at Home : Or, How I Learned to Stop Worrying About Recipes (And Love My Microwave): A Cookbook
- Author
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David Chang, Priya Krishna, David Chang, and Priya Krishna
- Subjects
- Cooking
- Abstract
NEW YORK TIMES BESTSELLER • The founder of Momofuku cooks at home... and that means mostly ignoring recipes, using tools like the microwave, and taking inspiration from his mom to get a great dinner done fast.JAMES BEARD AWARD NOMINEE • ONE OF THE BEST COOKBOOKS OF THE YEAR: New York Post, Taste of HomeDavid Chang came up as a chef in kitchens where you had to do everything the hard way. But his mother, one of the best cooks he knows, never cooked like that. Nor did food writer Priya Krishna's mom. So Dave and Priya set out to think through the smartest, fastest, least meticulous, most delicious, absolutely imperfect ways to cook. From figuring out the best ways to use frozen vegetables to learning when to ditch recipes and just taste and adjust your way to a terrific meal no matter what, this is Dave's guide to substituting, adapting, shortcutting, and sandbagging—like parcooking chicken in a microwave before blasting it with flavor in a four-minute stir-fry or a ten-minute stew. It's all about how to think like a chef... who's learned to stop thinking like a chef.
- Published
- 2021
38. Study of Cache-Enhanced Dynamic Movement-Based Location Management Schemes for 3G Cellular Networks
- Author
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Priya, Krishna, primary, Pan, Yi, additional, Lin, Xiaola, additional, Xiao, Yang, additional, and Li, Jie, additional
- Published
- 2006
- Full Text
- View/download PDF
39. Chronic Refractory Cough: Objective Improvement With Aerodynamic-Focused
- Author
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Brianna K. Crawley, Jin Yang, Thomas Murry, Priya Krishna, and Salem Dehom
- Subjects
Glottis ,business.industry ,Airway Resistance ,Respiration ,Maximum phonation time ,Objective Improvement ,LPN and LVN ,respiratory tract diseases ,Speech and Hearing ,Chronic cough ,Airway resistance ,Otorhinolaryngology ,Refractory ,Cough ,Phonation ,Anesthesia ,medicine ,Breathing ,Humans ,Cough symptoms ,medicine.symptom ,Larynx ,Training program ,business - Abstract
Previous investigations have reported that a chronic cough that is refractory to medical therapies improves with behavioral therapies. However, the treatment parameters that may account for improvement in cough symptoms have not yet been objectively documented. The purpose of this study was to document changes in chronic refractory cough using a breath training protocol.The charts of 27 patients with a long-term chronic cough (6 months) refractory to various medical treatments were reviewed. These patients received 2-4 sessions of breath training therapy over a 6-month period. Treatment sessions consisted of breathing modification exercises such as those reported in the literature. Aerodynamic parameters including mean estimated subglottal air pressure, mean airflow rate, laryngeal airway resistance, and maximum phonation time were obtained before treatment and 6 months after therapy. Patients also completed the Cough Severity Index at the first visit and 6 months after treatment.Twenty four of the 27 patients (M:F = 6:21), with a mean age of 62.4 (range = 28-78, median = 66) had significant Cough Severity Index improvement from 16.74 to 10.04 (P0.001) after therapy. Maximum phonation time increased significantly from 12.00 to 16.38 seconds (P= 0.006); mean estimated subglottic air pressure decreased significantly from 7.58 to 6.36 cm HThis investigation provides evidence that patients who followed a protocol that focused on a breath training program reduced their chronic cough. Significant relationships between patient self-assessment of chronic cough and aerodynamic measures of subglottic pressure and glottal airway resistance were found in this group.
- Published
- 2019
40. Indian-Ish : Recipes and Antics From a Modern American Family
- Author
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Priya Krishna and Priya Krishna
- Subjects
- Cooking, Indic, Cooking--United States
- Abstract
Named one of the Best Cookbooks of Spring 2019 by the New York Times, Eater, and Bon Appétit'A joy to cook from, and just as much fun to read.'—Margaux Laskey, the New York TimesA witty and irresistible celebration of one very cool and boundary-breaking mom's “Indian-ish” cooking—with accessible and innovative Indian-American recipes Indian food is everyday food! This colorful, lively book is food writer Priya Krishna's loving tribute to her mom's “Indian-ish” cooking—a trove of one-of-a-kind Indian-American hybrids that are easy to make, clever, practical, and packed with flavor. Think Roti Pizza, Tomato Rice with Crispy Cheddar, Whole Roasted Cauliflower with Green Pea Chutney, and Malaysian Ramen. Priya's mom, Ritu, taught herself to cook after moving to the U.S. while also working as a software programmer—her unique creations merging the Indian flavors of her childhood with her global travels and inspiration from cooking shows as well as her kids'requests for American favorites like spaghetti and PB&Js. The results are approachable and unfailingly delightful, like spiced, yogurt-filled sandwiches crusted with curry leaves, or “Indian Gatorade” (a thirst-quenching salty-sweet limeade)—including plenty of simple dinners you can whip up in minutes at the end of a long work day. Throughout, Priya's funny and relatable stories—punctuated with candid portraits and original illustrations by acclaimed Desi pop artist Maria Qamar (also known as Hatecopy)—will bring you up close and personal with the Krishna family and its many quirks.
- Published
- 2019
41. Gossypiboma: a ghastly find
- Author
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Priya Krishna, Hannah Louise Devlin, Aitor de Gea Rico, and Ashish Rohatgi
- Subjects
Adult ,Male ,Surgical Sponges ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,030232 urology & nephrology ,Gossypiboma ,Epigastric pain ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Laparotomy ,Abdomen ,medicine ,Humans ,Cyst ,business.industry ,General Medicine ,medicine.disease ,Foreign Bodies ,Surgery ,Abdominal Pain ,Gastrectomy ,Learning from Errors ,Presentation (obstetrics) ,business ,Tomography, X-Ray Computed ,030217 neurology & neurosurgery ,Foreign body granuloma - Abstract
A gossypiboma is a mass within a patient’s body comprising a cotton matrix surrounded by a foreign body granuloma. We describe an unusual presentation of a gossypiboma presenting in a 32-year-old man with acute epigastric pain and haematemesis. His surgical history revealed an emergency laparotomy following a road traffic accident 16 years ago. Initial gastroscopy showed extrinsic stomach compression. An abdominal ultrasound scan followed by a CT scan evidenced a large, well-defined, predominantly cystic mass with some solid areas occupying the left hypochondrium. Conservative management with insertion of a percutaneous drain proved to be inefficient. A laparotomy was performed; intraoperatively, the cyst was found to be ruptured and within it, a large surgical gauze was found. This was removed but required a distal pancreatectomy and gastrectomy for complete excision. He was discharged on day 74 of admission with outpatient follow-up.
- Published
- 2018
42. Medicolegal Aspects of Iatrogenic Dysphonia and Recurrent Laryngeal Nerve Injury
- Author
-
Yuan F. Liu, Priya Krishna, and Jennifer H. Ta
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Iatrogenic Disease ,Specialty ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Malpractice ,medicine ,Recurrent laryngeal nerve ,Humans ,Intubation ,Young adult ,030223 otorhinolaryngology ,Aged ,Aged, 80 and over ,Plaintiff ,business.industry ,Thyroidectomy ,Middle Aged ,Dysphonia ,Surgery ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Recurrent Laryngeal Nerve Injuries ,Female ,business ,Settlement (litigation) - Abstract
To examine aspects of litigation involving iatrogenic dysphonia and injury to the recurrent laryngeal nerve in the adult population.Legal database review.Medicolegal judicial system.Jury verdicts and settlement reports listing voice impairment or recurrent laryngeal nerve dysfunction as a primary injury in adult patients were identified in the Westlaw Database. Reports were examined for plaintiff demographics, defendant specialty, procedure performed, rates of settlements and verdicts, monetary awards, primary plaintiff symptoms, and common allegations.A total of 123 jury verdict and settlement reports were identified. General surgeons (24%), otolaryngologists (20%), and anesthesiologists (18%) were involved in the majority of cases. The procedure causing the alleged injury was primarily thyroidectomy (34%), followed by intubation (18%) and spinal instrumentation (10%). The majority of cases (70%) were decided in favor of the defendant. Where monetary awards were recorded, settlements and jury verdicts in favor of the plaintiff ranged between $4250 and $3,000,000, with a mean of $788,713. In addition to voice disturbances, complaints of dyspnea and dysphagia were commonly listed alleged injuries. The only factors associated with plaintiff verdicts were general surgery specialty (odds ratio, 6.3; 95% confidence interval, 1.7-23.2) and claims of loss of consortium (odds ratio, 8.5; 95% confidence interval, 1.2-60.7).Dysphonia is a common complication in a number of procedures across multiple specialties. Although the majority of cases are decided in favor or the defendant, payments awarded can be considerable. Awareness of factors involved in these medical malpractice cases can help limit physician liability.
- Published
- 2015
43. A comparative evaluation of antioxidant and antidiabetic potential of peel from young and matured potato
- Author
-
P. Jayamurthy, P. Nisha, Janu Chandran, Priya Krishna, K. B. Arun, and R. Dhanya
- Subjects
Antioxidant ,medicine.medical_treatment ,Glucose uptake ,Ethyl acetate ,Biochemistry ,High-performance liquid chromatography ,Comparative evaluation ,chemistry.chemical_compound ,Ros scavenging ,chemistry ,Dry weight ,medicine ,Food science ,Food Science - Abstract
In the present study antioxidant and antidiabetic potentials of potato peels at two different stages of maturity were evaluated and compared. Peels of young and mature potatoes (YP and MP) were sequentially extracted with hexane (HMP, HYP), ethyl acetate (EMP, EYP) and methanol (MMP, MYP). EMP and EYP were found to possess the highest phenolic content (83.2 and 44.14 mg GAE/g dry weight, respectively) and maximum radical scavenging efficacy for different antioxidant assays performed. EYP demonstrated better α-glucosidase inhibition activity (IC 50 -197.13 µg), intracellular ROS scavenging and induce glucose uptake in L6 rat skeletal muscle cells. Phenolic profiling of compounds (gallic, caffeic, ferulic and chlorogenic acids) in the active extracts were established using HPLC. The study demonstrated that YP exhibited better bioactive potential than that of MP. YP could be an excellent source of bioactive phytochemicals with antioxidant and antidiabetic potential.
- Published
- 2015
44. Aerodynamic Characteristics of Syllable and Sentence Productions in Normal Speakers
- Author
-
Cedric Thiel, Brianna K. Crawley, Thomas Murry, Priya Krishna, and Jin Yang
- Subjects
Conversational speech ,Adult ,Male ,medicine.medical_specialty ,Glottis ,Sound Spectrography ,Voice Quality ,Audiology ,Speech Acoustics ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,Young Adult ,0302 clinical medicine ,Phonation ,Speech Production Measurement ,Predictive Value of Tests ,medicine ,Pressure ,Humans ,030223 otorhinolaryngology ,Surgical treatment ,Reproducibility of Results ,LPN and LVN ,Healthy Volunteers ,Voice therapy (transgender) ,Subglottic pressure ,Variation (linguistics) ,Otorhinolaryngology ,Female ,Syllable ,0305 other medical science ,Psychology ,Sentence - Abstract
Summary Background Aerodynamic measures of subglottic air pressure (Ps) and airflow rate (AFR) are used to select behavioral voice therapy versus surgical treatment for voice disorders. However, these measures are usually taken during a series of syllables, which differs from conversational speech. Repeated syllables do not share the variation found in even simple sentences, and patients may use their best rather than typical voice unless specifically instructed otherwise. This study examined the potential differences in estimated Ps and AFR in syllable and sentence production and their effects on a measure of vocal efficiency in normal speakers. Methods Prospective study. Measures of estimated Ps, AFR, and aerodynamic vocal efficiency (AVE) were obtained from 19 female and four male speakers ages 22–44 years with no history of voice disorders. Subjects repeated a series of /pa/ syllables and a sentence at comfortable effort level into a face mask with a pressure-sensing tube between the lips. Results AVE varies as a function of the speech material in normal subjects. Ps measures were significantly higher for the sentence-production samples than for the syllable-production samples. AFR was higher during sentence production than syllable production, but the difference was not statistically significant. AVE values were significantly higher for syllable versus sentence productions. Conclusions The results suggest that subjects increase Ps and AFR in sentence compared with syllable production. Speaking task is a critical factor when considering measures of AVE, and this preliminary study provides a basis for further aerodynamic studies of patient populations.
- Published
- 2017
45. Perception and duration of pain after office-based vocal fold injection augmentation
- Author
-
Brianna K, Crawley, Salem, Dehom, Emily, Kutzner, Thomas, Murry, Priya, Krishna, and Justin, Hata
- Subjects
Adult ,Aged, 80 and over ,Male ,Pain, Postoperative ,Laryngoscopy ,Voice Quality ,Biocompatible Materials ,Vocal Cords ,Middle Aged ,Injections ,Durapatite ,Treatment Outcome ,Humans ,Female ,Perception ,Prospective Studies ,Vocal Cord Paralysis ,Aged ,Follow-Up Studies ,Pain Measurement - Abstract
In-office laryngology procedures are important in the treatment of voice and swallowing disorders. Patient tolerance determines which procedures can be performed without sedation or formal anesthesia. This study examines pain perception during and after in-office vocal fold injection augmentation.Prospective cohort study.Patients scheduled for office-based vocal fold injection augmentation were prospectively enrolled at an academic voice center. The short-form McGill Pain Questionnaire was administered before, during, and after the procedure and on postprocedure days 1, 3, and 7. Pre- and postprocedure vital signs were recorded and heart rate was continuously monitored. Telephone questionnaires were completed on postprocedure days 1 and 3.Forty-five patients consented to participate in our study (24 males, mean age 61 years). Most patients experienced mild to moderate pain with increasing heart rate during the procedure. Pain remained or increased 20 minutes after the procedure and improved but persisted for 1 day. Sensory and affective discomfort was endorsed by the majority. A minority of patients experienced bruising and changes in swallowing with diet modification for 3 days after the procedure. Sixteen percent had discomfort after 1 week.This is the first prospective study examining patient perception of pain during and after in-office injection augmentation using a validated scale and pain descriptors with extended follow-up. The results may offer guidance for patient counseling, consent, and treatment to improve tolerance and success.4. Laryngoscope, 128:929-934, 2018.
- Published
- 2017
46. Esophagram findings in cervical esophageal stenosis: A case-controlled quantitative analysis
- Author
-
Jacob, West, Cherine H, Kim, Zachary, Reichert, Priya, Krishna, Brianna K, Crawley, and Jared C, Inman
- Subjects
Male ,Contrast Media ,Middle Aged ,Dilatation ,Sensitivity and Specificity ,Esophagus ,ROC Curve ,Reference Values ,Case-Control Studies ,Cervical Vertebrae ,Esophageal Stenosis ,Humans ,Female ,Barium Sulfate ,Deglutition Disorders ,Tomography, X-Ray Computed ,Aged ,Retrospective Studies - Abstract
Cervical esophageal stenosis is often diagnosed with a qualitative evaluation of a barium esophagram. Although the esophagram is frequently the initial screening exam for dysphagia, a clear objective standard for stenosis has not been defined. In this study, we measured esophagram diameters in order to establish a quantitative standard for defining cervical esophageal stenosis that requires surgical intervention.Single institution case-control study.Patients with clinically significant cervical esophageal stenosis defined by moderate symptoms of dysphagia (Functional Outcome Swallowing Scale 2 and Functional Oral Intake Scale 6) persisting for 6 months and responding to dilation treatment were matched with age, sex, and height controls. Both qualitative and quantitative barium esophagram measurements for the upper, mid-, and lower vertebral bodies of C5 through T1 were analyzed in lateral, oblique, and anterior-posterior views.Stenotic patients versus nonstenotic controls showed no significant differences in age, sex, height, body mass index, or ethnicity. Stenosis was most commonly at the sixth cervical vertebra (C 6) lower border and C7 upper border. The mean intraesophageal minimum/maximum ratios of controls and stenotic groups in the lateral view were 0.63 ± 0.08 and 0.36 ± 0.12, respectively (P 0.0001). Receiver operating characteristic analysis of the minimum/maximum ratios, with a0.50 ratio delineating stenosis, demonstrated that lateral view measurements had the best diagnostic ability. The sensitivity of the radiologists' qualitative interpretation was 56%. With application of lateral intraesophageal minimum/maximum ratios, we observed improved sensitivity to 94% of the esophagram, detecting clinically significant stenosis.Applying quantitative determinants in esophagram analysis may improve the sensitivity of detecting cervical esophageal stenosis in dysphagic patients who may benefit from surgical therapy.IIIb. Laryngoscope, 128:2022-2028, 2018.
- Published
- 2017
47. Prospective investigation of nimodipine for acute vocal fold paralysis
- Author
-
Libby J. Smith, VyVy N. Young, Priya Krishna, Michael C. Munin, Clark A. Rosen, and Matthew F. Muldoon
- Subjects
medicine.medical_specialty ,Physiology ,business.industry ,Vocal fold paralysis ,Laryngeal electromyography ,medicine.disease ,Surgery ,Cellular and Molecular Neuroscience ,Animal model ,medicine.anatomical_structure ,Recovery rate ,Open label study ,Physiology (medical) ,Anesthesia ,Vocal folds ,Medicine ,Neurology (clinical) ,Vocal cord paralysis ,business ,Nimodipine ,medicine.drug - Abstract
Introduction: Nimodipine has been shown to be beneficial for recovery from acute vocal fold paralysis (AVFP) in an animal model. Methods: prospective, open-label trial of patients with AVFP was performed using nimodipine. Consecutive patients were evaluated and offered nimodipine therapy. Results: Fifty-three patients were considered for treatment with nimodipine. Thirteen did not qualify for inclusion, 5 were lost to follow-up, and 7 had side effects requiring cessation of treatment. Thus 28 patients (30 paralyzed vocal folds) were analyzed. Eighteen of the paralyzed vocal folds experienced recovery of purposeful motion (60%). Historical controls and laryngeal electromyography meta-analysis suggest no more than a 20% recovery rate from AVFP. Conclusions: This open label study using nimodipine for treatment of AVFP demonstrates tripling of the recovery rate of vocal fold motion compared with historical controls. Further study in a randomized, controlled manner is warranted. Muscle Nerve 50: 114–118, 2014
- Published
- 2014
48. Thrombosis of Both Umbilical Arteries of a Female Fetus in a Twin Gestation Causing Fetal Demise
- Author
-
Bhat, Shubha P., Paul, Riturupa, Srinivas, Teerthanath, Sonkusare, Shipra, and Priya, Krishna
- Published
- 2021
- Full Text
- View/download PDF
49. Patient-Centered Foodservice Model Improves Body Weight, Nutritional Intake and Patient Satisfaction in Patients Undergoing Cancer Treatment
- Author
-
Sathiaraj, Esther, primary, Priya, Krishna, additional, Chakraborthy, Shalini, additional, and Rajagopal, Revathi, additional
- Published
- 2018
- Full Text
- View/download PDF
50. Orthodontic management of palatally impacted canine
- Author
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Ramanathan, Thirunavukkarasu, primary, Jayachandran, Tamizhmani, additional, Nirupama, C, additional, Anand, Suresh, additional, Chandrasekaran, Prashanth, additional, and Priya, Krishna, additional
- Published
- 2018
- Full Text
- View/download PDF
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