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4. RETRACTED: Alhakamy et al. Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment. Pharmaceutics 2022, 14, 1133

Author

Alhakamy, Nabil A., primary, Caruso, Giuseppe, additional, Privitera, Anna, additional, Ahmed, Osama A. A., additional, Fahmy, Usama A., additional, Md, Shadab, additional, Mohamed, Gamal A., additional, Ibrahim, Sabrin R. M., additional, Eid, Basma G., additional, Abdel-Naim, Ashraf B., additional, and Caraci, Filippo, additional

Published
2024
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5. Gain-Type Aneuploidies Influence the Burden of Selective Long Non-Coding Transcripts in Colorectal Cancer.

Author

Scuderi, Chiara, Di Bella, Virginia, Privitera, Anna Provvidenza, Giustolisi, Francesca Maria, Barresi, Vincenza, and Condorelli, Daniele Filippo

Subjects
COLORECTAL cancer, LINCRNA, CHROMOSOME abnormalities, COLON tumors, NON-coding RNA, CIRCULAR RNA
Abstract

Chromosomal instability is a hallmark of colorectal carcinogenesis and produces an accumulation of different forms of aneuploidies or broad copy number aberrations. Colorectal cancer is characterized by gain-type broad copy number aberrations, specifically in Chr20, Chr8q, Chr13 and Chr7, but their roles and mechanisms in cancer progression are not fully understood. It has been suggested that broad copy number gains might contribute to tumor development through the so-called caricature transcriptomic effect. We intend to investigate the impact of broad copy number gains on long non-coding RNAs' expression in colorectal cancer, given their well-known role in oncogenesis. The influence of such chromosomal aberrations on lncRNAs' transcriptome profile was investigated by SNP and transcriptome arrays in our series of colorectal cancer samples and cell lines. The correlation between aneuploidies and transcriptomic profiles led us to obtain a class of Over-UpT lncRNAs, which are transcripts upregulated in CRC and further overexpressed in colon tumors bearing specific chromosomal aberrations. The identified lncRNAs can contribute to a wide interaction network to establish the cancer driving effect of gain-type aneuploidies. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Characterization of Carnosine Effect on Human Microglial Cells under Basal Conditions

Author

Caruso, Giuseppe, primary, Privitera, Anna, additional, Saab, Miriam Wissam, additional, Musso, Nicolò, additional, Maugeri, Salvatore, additional, Fidilio, Annamaria, additional, Privitera, Anna Provvidenza, additional, Pittalà, Alessandra, additional, Jolivet, Renaud Blaise, additional, Lanzanò, Luca, additional, Lazzarino, Giuseppe, additional, Caraci, Filippo, additional, and Amorini, Angela Maria, additional

Published
2023
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9. Microfluidic/HPLC combination to study carnosine protective activity on challenged human microglia: Focus on oxidative stress and energy metabolism

Author

Privitera, Anna, primary, Cardaci, Vincenzo, additional, Weerasekara, Dhanushka, additional, Saab, Miriam Wissam, additional, Diolosà, Lidia, additional, Fidilio, Annamaria, additional, Jolivet, Renaud Blaise, additional, Lazzarino, Giuseppe, additional, Amorini, Angela Maria, additional, Camarda, Massimo, additional, Lunte, Susan Marie, additional, Caraci, Filippo, additional, and Caruso, Giuseppe, additional

Published
2023
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10. Effects of carnosine on the embryonic development and TiO2 nanoparticles-induced oxidative stress on Zebrafish

Author

Caruso, Giuseppe, primary, Scalisi, Elena Maria, additional, Pecoraro, Roberta, additional, Cardaci, Vincenzo, additional, Privitera, Anna, additional, Truglio, Emanuela, additional, Capparucci, Fabiano, additional, Jarosova, Romana, additional, Salvaggio, Antonio, additional, Caraci, Filippo, additional, and Brundo, Maria Violetta, additional

Published
2023
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11. Prenatal stress induces a depressive-like phenotype in adolescent rats: The key role of TGF-β1 pathway

Author

Fidilio, Annamaria, primary, Grasso, Margherita, additional, Caruso, Giuseppe, additional, Musso, Nicolò, additional, Begni, Veronica, additional, Privitera, Anna, additional, Torrisi, Sebastiano Alfio, additional, Campolongo, Patrizia, additional, Schiavone, Stefania, additional, Tascedda, Fabio, additional, Leggio, Gian Marco, additional, Drago, Filippo, additional, Riva, Marco Andrea, additional, and Caraci, Filippo, additional

Published
2022
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12. Supplementary Material

Author

Caruso Giuseppe, Scalisi Elena Maria, Pecoraro Roberta, Cardaci Vincenzo, Privitera Anna, Truglio Emanuela, Capparucci Fabiano, Jarosova Romana, Salvaggio Antonio, Caraci Filippo, and Brundo Maria Violetta

Abstract

Supplementary Figure 1: Increasing concentrations of carnosine (0.1, 1, 10, and 20 mM) do not cause malformation on the larvae. Supplementary Videos: Increasing concentrations of carnosine (0.1, 1, 10, and 20 mM) do not cause alterations in the heartbeat of the embryos/larvae.

Published
2022
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17. Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease

Author

Caruso, Giuseppe, primary, Grasso, Margherita, additional, Fidilio, Annamaria, additional, Torrisi, Sebastiano Alfio, additional, Musso, Nicolò, additional, Geraci, Federica, additional, Tropea, Maria Rosaria, additional, Privitera, Anna, additional, Tascedda, Fabio, additional, Puzzo, Daniela, additional, Salomone, Salvatore, additional, Drago, Filippo, additional, Leggio, Gian Marco, additional, and Caraci, Filippo, additional

Published
2021
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18. NUP-98 Rearrangements Led to the Identification of Candidate Biomarkers for Primary Induction Failure in Pediatric Acute Myeloid Leukemia

Author

Barresi, Vincenza, primary, Di Bella, Virginia, additional, Andriano, Nellina, additional, Privitera, Anna Provvidenza, additional, Bonaccorso, Paola, additional, La Rosa, Manuela, additional, Iachelli, Valeria, additional, Spampinato, Giorgia, additional, Pulvirenti, Giulio, additional, Scuderi, Chiara, additional, Condorelli, Daniele F., additional, and Lo Nigro, Luca, additional

Published
2021
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30. La scarsa attendibilità del CAP come riferimento geografico in Italia.

Author

Ronconi, Marianna, Pasquinelli, Alice, Privitera, Anna, and Guzzetti, Franco

Abstract

Many software made in the USA for analyzing big territorial risks use Post Code (P .C.) as a geographical reference. However, if those software are used in Italy, the purpose of the Post Code as territorial reference results unsuitable. In fact, in Italy the P .C. was created to facilitate the processes of mail delivery. It is made up of a five numbers code and the level of information contained decreases the deeper the code is analyzed and the more their territorial continuity fails. Moreover, at times a single Post Code refers to multiple towns, at others a single town can be divided in various P .C. This article shows some examples on how the Post Code can not be used in Italy for analyze territorial distribution of natural disasters. [ABSTRACT FROM AUTHOR]

Published
2016

31. La fontana, il mare, la sirena, la neve, lo stagno. Metafore acquatiche e simbolismo della liquidità nel 'Pelléas et Mélisande'

Author

MISURACA, Pietro, Maria Antonella Balsano, Paolo Emilio Carapezza, Giuseppe Collisani, Pietro Misuraca, Massimo Privitera, Anna Tedesco, and Pietro Misuraca

Subjects
Settore L-ART/07 - Musicologia E Storia Della Musica, Debussy, acqua, simbolismo
Abstract

Mobile e fluida come le percezioni inconsce, l'acqua è il tema simbolista per eccellenza. Anche la musica di Debussy si impregna di "liquidità", in un coinvolgimento delle dimensioni più profonde dello stile e del linguaggio, per rendersi capace di confrontarsi con il Mistero. Nel "Pelléas et Mélisande" di Maeterlinck, con la sua lingua evocatrice, le sue allusioni non risolte e i suoi simboli misteriosi, Debussy trova il suo linguaggio; così come, di riflesso, nel suo mondo sonoro privo di dialettica, statico e senza meta si incarna mirabilmente la dimensione esistenziale del dramma. Ossessione ricorrente, l'elemento liquido fa da sfondo simbolico a diverse scene: come in tutta la cultura dell'epoca - letteraria, pittorica e musicale -sono presenti diverse immagini acquatiche che investono, con le loro valenze simboliche, la vita e la morte.

Published
2016

32. Due volti della notte. Su Arthur Schopenhauer e Richard Wagner

Author

OLIVERI, Dario, Maria Antonella Balsano, Paolo Emilio Carapezza, Giuseppe Collisani, Pietro Misuraca, Massimo Privitera, Anna Tedesco., AA.VV., and Oliveri, D

Subjects
Filosofia, estetica musicale, romanticismo, musica, Arthur Schopenhauer, Richard Wagner, Il mondo come volontà e rappresentazione, L'anello del Nibelungo, L'oro del Reno, Tristano e Isotta, Settore L-ART/07 - Musicologia E Storia Della Musica
Abstract

Il saggio prende le mosse dalla concezione dell'arte espressa da Arthur Schopenhauer nel "Mondo come volontà e rappresentazione" (1818; IIa ed. 1844), soffermandosi in maniera particolare sul Capitolo 52 e sull'idea di un'interpretazione metafisica della musica. Tale ipotesi viene messa in rapporto con l'esperienza compositiva di Richard Wagner a partire dalla concezione del "Ring des Nibelungen" e con particolare riferimento al linguaggio armonico di "Tristan und isolde". In nota viene riportato il frammento di una lettera di Richard Wagner ad Arthur Schopenhauer, databile intorno al 1857.

Published
2016

33. Effects of carnosine on the embryonic development and TiO 2 nanoparticles-induced oxidative stress on Zebrafish.

Author

Caruso G, Scalisi EM, Pecoraro R, Cardaci V, Privitera A, Truglio E, Capparucci F, Jarosova R, Salvaggio A, Caraci F, and Brundo MV

Abstract

Oxidative stress is due to an unbalance between pro-oxidants, such as reactive oxygen (ROS) and nitrogen (RNS) species, and antioxidants/antioxidant system. Under physiological conditions these species are involved in different cellular processes such as cellular homeostasis and immune response, while an excessive production of ROS/RNS has been linked to the development of various diseases such as cancer, diabetes, and Alzheimer's disease. In this context, the naturally occurring dipeptide carnosine has shown the ability to scavenge ROS, counteract lipid peroxidation, and inhibit proteins oxidation. Titanium dioxide nanoparticles (TiO 2 -NPs) have been widely used to produce cosmetics, in wastewater treatment, in food industry, and in healthcare product. As consequence, these NPs are often released into aquatic environments. The Danio rerio (commonly called zebrafish) embryos exposure to TiO 2 -NPs did not affect the hatching rate, but induced oxidative stress. According to this scenario, in the present study, we first investigated the effects of carnosine exposure and of a sub-toxic administration of TiO 2 -NPs on the development and survival of zebrafish embryos/larvae measured through the acute embryo toxicity test (FET-Test). Zebrafish larvae represent a useful model to study oxidative stress-linked disorders and to test antioxidant molecules, while carnosine was selected based on its well-known multimodal mechanism of action that includes a strong antioxidant activity. Once the basal effects of carnosine were assessed, we then evaluated its effects on TiO 2 -NPs-induced oxidative stress in zebrafish larvae, measured in terms of total ROS production (measured with 2,7-dichlorodihydrofluorescein diacetate probe) and protein expression by immunohistochemistry of two cellular stress markers, 70 kDa-heat shock protein (Hsp70) and metallothioneins (MTs). We demonstrated that carnosine did not alter the phenotypes of both embryos and larvae of zebrafish at different hours post fertilization. Carnosine was instead able to significantly decrease the enhancement of ROS levels in zebrafish larvae exposed to TiO 2 -NPs and its antioxidant effect was paralleled by the rescue of the protein expression levels of Hsp70 and MTs. Our results suggest a therapeutic potential of carnosine as a new pharmacological tool in the context of pathologies characterized by oxidative stress such as neurodegenerative disorders., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Caruso, Scalisi, Pecoraro, Cardaci, Privitera, Truglio, Capparucci, Jarosova, Salvaggio, Caraci and Brundo.)

Published
2023
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