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5. Curcumin Modulates Nitrosative Stress, Inflammation, and DNA Damage and Protects against Ochratoxin A-Induced Hepatotoxicity and Nephrotoxicity in Rats

Author

Longobardi C, Damiano S, Andretta E, Prisco F, Russo V, Pagnini F, Florio S, Ciarcia R., Longobardi, C, Damiano, S, Andretta, E, Prisco, F, Russo, V, Pagnini, F, Florio, S, and Ciarcia, R.

Subjects
hepatotoxicity, inflammation, nephrotoxicity, nitrosative stre, DNA damage, ochratoxin A
Abstract

Ochratoxin A (OTA) is a fungal toxin of critical concern for food safety both for human health and several animal species, also representing a cancer threat to humans. Curcumin (CURC) is a natural polyphenol that has anti-apoptotic, anti-inflammatory, and antioxidant effects. The aim of this study was to investigate the cytoprotective effect of CURC against OTA-induced nephrotoxicity and hepatotoxicity through the study of the nitrosative stress, pro-inflammatory cytokines, and deoxyribonucleic acid (DNA) damage. Sprague Dawley rats were daily treated with CURC (100 mg/kg b.w.), OTA (0.5 mg/kg b.w), or CURC with OTA by oral gavage for 14 days. Our results demonstrated that OTA exposure was associated with significant increase of pro-inflammatory and DNA oxidative-damage biomarkers. Moreover, OTA induced the inducible nitric oxide synthase, (iNOS) resulting in increased nitric oxide (NO) levels both in kidney and liver. The co-treatment OTA + CURC counteracted the harmful effects of chronic OTA treatment by regulating inflammation, reducing NO levels and oxidative DNA damage in kidney and liver tissues. Histology revealed that OTA + CURC treatment determinates mainly an Iba1+ macrophagic infiltration with fewer CD3+ T-lymphocytes in the tissues. In conclusion, we evidenced that CURC exerted cytoprotective and antioxidant activities against OTA-induced toxicity in rats.

Published
2021

8. The correlation between cardiac and skeletal muscle pathology in animal models of idiopathic inflammatory myopathies

Author

Prisco F., Papparella S., Paciello O., Prisco, F., Papparella, S., and Paciello, O.

Subjects
Myocarditi, Animal model, Idiopathic inflammatory myopathy, Myositi, Neuromuscular disorders
Abstract

Idiopathic inflammatory myopathies (IIMs) represent a heterogeneous group of disorders in which skeletal muscle is inappropriately targeted by the immune system. IIMs are characterized by inflammation of muscle and varying degrees of muscle dysfunction. Extra-muscular manifestations may involve heart, skin, joints, lungs, and gastrointestinal tract. Cardiovascular involvement is a feared event because is one of the leading causes of mortality in IIM patients. As the myocardium shares many features with the skeletal muscle, it is supposed that it can be affected by the same inflammatory processes, which take place during the different forms of IIMs. However, the full extent of this link and the mechanisms behind it are still not fully understood. Animal models have greatly improved our understanding of IIM pathomechanisms and have proven to be a useful tool for discovering therapeutic drug targets. Here we report the evidence of heart muscle involvement in different animal models of spontaneous IIMs, assuming a common autoimmune mechanism and presenting them as study models for human pathology.

Published
2020

13. Sulfonylurea treatment outweighs insulin therapy in short-term metabolic control of patients with permanent neonatal diabetes mellitus due to activating mutations of the KCNJ11 (KIR6.2) gene

Author

Tonini, G., Bizzarri, C., Bonfanti, R., Vanelli, M., Cerutti, F., Faleschini, E., Meschi, F., Prisco, F., Ciacco, E., Cappa, M., Torelli, C., Cauvin, V., Tumini, S., Iafusco, D., Barbetti, F., and Early-Onset Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetology

Published
2006
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15. Permanent diabetes mellitus in the first year of life

Author

Iafusco, D., Stazi, M., Cotichini, R., Cotellessa, M., Martinucci, M., Mazzella, M., Cherubini, V., Barbetti, F., Martinetti, M., Cerutti, F., Prisco, F., and and the Early Onset Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetology

Published
2002
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22. Studio delle patologie tiroidee nella pecora in aree contaminate

Author

De Biase, D, Piegari, G, Prisco, F, Bosco, A, Genovese, A, Cringoli, G, Paciello, O., Società italiana di Patologia ed Allevamento degli Ovini e dei Caprini (SIPAOC), De Biase, D, Piegari, G, Prisco, F, Bosco, A, Genovese, A, Cringoli, G, and Paciello, O.

Published
2018

25. Anti-skeletal muscle antibodies in sera of dogs with leishmaniasis

Author

Prisco F, Piegari G, De Biase D, Oriente F, Ricci S, Cimmino I, Pagnini U, Gizzarelli M, Oliva G, Papparella S, Paciello O, SISVet, Prisco, F, Piegari, G, De Biase, D, Oriente, F, Ricci, S, Cimmino, I, Pagnini, U, Gizzarelli, M, Oliva, G, Papparella, S, and Paciello, O

Published
2017

27. Serologic and molecular diagnostic survey of vector-borne disease-causing pathogens in hunting dogs from Southern Italy

Author

Pantchev N, Veneziano V, Piantedosi D, Neola B, D’Alessio N, Di Prisco F, Santoro M, Pacifico L, Sgroi G, Auletta L, Leutenegger C, Tyrrell P, Buch J, Ramaswamy C, WAAVP, Pantchev, N, Veneziano, V, Piantedosi, D, Neola, B, D’Alessio, N, Di Prisco, F, Santoro, M, Pacifico, L, Sgroi, G, Auletta, L, Leutenegger, C, Tyrrell, P, Buch, J, and Ramaswamy, C

Abstract

Canine vector-borne diseases (CVBDs) result from a range of pathogens transmitted to dogs by arthropods. The present study aimed to examine a population of hunting dogs from southern Italy using both serological and molecular diagnostic methods for evidence of infection by known pathogens of CVBDs. Blood samples were collected from hunting dogs (n. 1,191) in the Avellino and Salerno provinces of Campania region of southern Italy. Serological testing for Ehrlichia canis, Anaplasma spp., and Borrelia burgdorferi sensu lato-specific antibodies and Dirofilaria immitis-specific antigen was performed using a commercial in-clinic enzyme-linked immunosorbent assay kit, SNAP® 4Dx® Plus. Molecular diagnostic testing for the blood-borne presence of Ehrlichia canis, Ehrlichia chaffeensis, Anaplasma platys, Anaplasma phagocytophilum, Babesia canis, Babesia vogeli, Babesia gibsoni, Dirofilaria immitis, Dirofilaria repens, Hepatozoon canis, and Leishmania spp. was performed by real time polymerase chain reaction (RT-PCR) assays. Seropositive rates for the four individual pathogens were: E.canis 7.7%; Anaplasma spp. 4.2%; D.immitis,1.4%; and B.burgdorferi s.l. 0.3%. PCR positive rates for eight detected pathogens were: H.canis 16.8%; A.platys 2.4%; E.canis 1.9%; B.vogeli 1.6%; Leishmania spp. 0.4%; B.canis 0.2%; D.repens 0.2%; and D.immitis 0.1%. Co-infections were detected at a rate of 2.3% by serology and 2.7% by RT-PCR with Anaplasma/E.canis and E.canis/H.canis co-infections occurring most frequently by serology and PCR, respectively. The results of present survey indicate that hunting dog populations are at risk of CVBDs in southern Italy. Further studies are needed to evaluate the role of hunting dogs in the epidemiology of vector-borne agents and the relationship to sympatric populations of wild animals.

Published
2017

32. Organization and regional distribution of centers for the management of children and adolescents with diabetes in Italy

Author

Giorgetti C., Ferrito L., Zallocco F., Iannilli A., Cherubini V., Maghnie M., Rabbone I., Lera R., De Luna L., Kienberger B., Gualtieri A., Zecchino C., Piccino E., Ortolani F., Zucchini S., Maltoni G., Pasquino B., Reinstadler P., Prandi E., Zattoni V., Gallo F., Morganti G., Guerraggio L., Ripoli C., Frongia M., Pusceddu P., La Loggia A., Scanu P., Cardinale G., Ponzi G., Tomaselli L. G., Rapisarda V., Citriniti F., Soprani T., Tumini S., Lazzaro N., De Donno V., Banin P., Toni S., Lenzi L., Mainetti B., Coccioli M. S., D'Annunzio G., Minuto N., Montani E., Maccioni R., Marongiu U., Beccaria L., Bruzzese M., Mammi F., Pardi D., Lombardo F., Ventrici C., Scaramazza A., Ferrari M., Bonfanti R., Rigamonti A., Iughetti L., Predieri B., Iafusco D., Confetto S., Zanfardino A., Prisco F., Francese A., De Nitto E., Cadario F., Milia A., Piredda G., Mereu L., Soro M., Correddu A., Pipia A., Monciotti C., Cardella F., De Berardinis F., Santoro G., Chiari G., Berioli M. G., Federico G., Zanette G., Marsciani A., Pedini A., Patera I. P., Schiaffini R., Bitti M., Lidano R., Pietrosanti S., Delvecchio M., Trada M., Marinaro A., Meloni G., Galero A., Fichera G., Bulciolu P., Ignaccolo G., Cauvin V., Franceschi R., Faleschini E., Tornese G., Salvatoni A., Cardani R., Maffeis C., Marigliano M., Sabbion A., Arnaldi C., Giorgetti, Chiara, Ferrito, Lucia, Zallocco, Federica, Iannilli, Antonio, Cherubini, Valentino, Maghnie, Mohamad, Rabbone, Ivana, Lera, R., De Luna, L., Kienberger, B., Gualtieri, A., Zecchino, C., Piccino, E., Ortolani, F., Zucchini, S., Maltoni, G., Pasquino, B., Reinstadler, P., Prandi, E., Zattoni, V., Gallo, F., Morganti, G., Guerraggio, L., Ripoli, C., Frongia, M., Pusceddu, P., La Loggia, A., Scanu, P., Cardinale, G., Ponzi, G., Tomaselli, L. G., Rapisarda, V., Citriniti, F., Soprani, T., Tumini, S., Lazzaro, N., De Donno, V., Banin, P., Toni, S., Lenzi, L., Mainetti, B., Coccioli, M. S., D’Annunzio, G., Minuto, N., Montani, E., Maccioni, R., Marongiu, U., Beccaria, L., Bruzzese, M., Mammì, F., Pardi, D., Lombardo, F., Ventrici, C., Scaramazza, A., Ferrari, M., Bonfanti, R., Rigamonti, A., Iughetti, L., Predieri, B., Iafusco, Dario, Confetto, S., Zanfardino, A., Prisco, Francesco, Francese, A., De Nitto, E., Cadario, F., Milia, A., Piredda, G., Mereu, L., Soro, M., Correddu, A., Pipia, A., Monciotti, C., Cardella, F., De Berardinis, F., Santoro, G., Chiari, G., Berioli, M. G., Federico, G., Zanette, G., Marsciani, A., Pedini, A., Patera, I. P., Schiaffini, R., Bitti, M., Lidano, R., Pietrosanti, S., Delvecchio, M., Trada, M., Marinaro, A., Meloni, G., Galero, A., Fichera, G., Bulciolu, P., Rabbone, I., Ignaccolo, G., Cauvin, V., Franceschi, R., Faleschini, E., Tornese, G., Salvatoni, A., Cardani, R., Maffeis, C., Marigliano, M., Sabbion, A., Arnaldi, C., Study Group for Diabetes of, Isped, Tornese, Gianluca, Giorgetti, C., Ferrito, L., Zallocco, F., Iannilli, A., Cherubini, V., Maghnie, M., D'Annunzio, G., Mammi, F., Iafusco, D., and Prisco, F.

Subjects
Male, medicine.medical_specialty, Type 1 diabete, Adolescent, MEDLINE, Staffing, Distribution (economics), Legislation, diabetes, children, T1D, Italy, Pediatrics, Regional Medical Program, Prevalence, Surveys and Questionnaire, Medicine, Regional legislation, Practice Patterns, Physicians', Disease management (health), Child, Organization of care, Pediatric diabetes centers, Type 1 diabetes, Pediatrics, Perinatology and Child Health, business.industry, Incidence, Incidence (epidemiology), Research, Disease Management, Perinatology and Child Health, medicine.disease, Diabetes Mellitus, Type 1, diabete, Family medicine, Female, Organizational structure, Pediatric diabetes center, business, Delivery of Health Care, Human
Abstract

Background: The incidence of type 1 diabetes in childhood is increasing by 3 % per year, placing growing demands on healthcare professionals and medical expenditures. Aim of this study wars to assess the organization of care to children with diabetes in Italy. Methods: During 2012 a structured questionnaire was sent to all of the members of Italian Society of Paediatric Endocrinology and Diabetology (ISPED). Questions examined organizational structure of Centers, personnel dedicated to the care of children with diabetes, number of subjects followed, local legal legislation supporting centres. Results: A total of 68 centers taking care to 15,563 children and adolescents with diabetes under 18 years of age were identified with a prevalence of 1.4 per 1,000 people. A wide variation in the organizational background was also reported. Fourty-four centers were organized as outpatient departments, 17 as simple units, 5 as complex units and 2 as simple departmental structures. Most centers had a multidisciplinary team. Ten out of twenty Italian regions had introduced supportive regional legislation, but it was fully applied only in six of them. Conclusion: Great differences between regions were found in organizational structures, staffing levels and supportive legislation. The national legislation on diabetes was broadly implemented throughout the country regions. Further efforts are needed to improve standards and consistency of pediatric diabetes care in Italy.

Published
2015

33. Molecular survey of Leishmania infection in red foxes (Vulpes vulpes) from southern and central Italy

Author

PIANTEDOSI, DIEGO, VENEZIANO, VINCENZO, FOGLIA MANZILLO, VALENTINA, OLIVA, GAETANO, Di Prisco F., Zottola, T., D'Alessio N., Santoro, M., Mariani, U., Fagiolo, A., Di Muccio, T., Fiorentino, E., Scalone, A., Neola, B., Gradoni, L., Gramiccia, M., Alica Kočišová, Marián Prokeš, Peter Lazar, Martin Tomko, Piantedosi, Diego, Veneziano, Vincenzo, Di Prisco, F., Zottola, T., D'Alessio, N., Santoro, M., Mariani, U., Fagiolo, A., Di Muccio, T., FOGLIA MANZILLO, Valentina, Fiorentino, E., Scalone, A., Neola, B., Gradoni, L., Oliva, Gaetano, and Gramiccia, M.

Subjects
Leihmania infantum, red fox, Italy
Abstract

The aim of this study was to investigate on the prevalence of L. infantum infection in foxes living in two distinct areas of southern and central Italy. Sixty eight carcasses of foxes were subjected to PCR analysis. At external examination no clinical signs of leishmaniasis were recorded. Ten foxes were found to be positive by Leishmania nested-PCR, of which 4 in spleen, 2 in lymph nodes and 4 in both organs. Our results show that in southern and central Italy foxes may me subclinically infected by Leishmania, but their importance as reservoirs for the maintenance of the infection remains to be determined.

Published
2015

34. Il Diabete Mitocondriale: se lo cerchi lo trovi

Author

IAFUSCO, DARIO, SACCHETTI, LUCIA, MAZZACCARA, CRISTINA, Liguori R., Ferrigno M., Libondi T., Simonelli F., Zanfardino A., Piscopo A., Pisani F., Casaburo F., Russo L., Villano P., Picariello S., Lancuba M., Forgione E., Caredda E., Iannalfo M., Pinelli M., Acquaviva F., Confetto S., Pelliccia C., Cocca A., Prisco F., Iafusco D., Sacchetti L., Mazzaccara C., Liguori R., Ferrigno M., Libondi T., Simonelli F., Zanfardino A., Piscopo A., Pisani F., Casaburo F., Russo L., Villano P., Picariello S., Lancuba M., Forgione E., Caredda E., Iannalfo M., Pinelli M., Acquaviva F., Confetto S., Pelliccia C., Cocca A., Prisco F., Iafusco, Dario, Sacchetti, Lucia, Mazzaccara, Cristina, Liguori, R., Ferrigno, M., Libondi, T., Simonelli, F., Zanfardino, A., Piscopo, A., Pisani, F., Casaburo, F., Russo, L., Villano, P., Picariello, S., Lancuba, M., Forgione, E., Caredda, E., Iannalfo, M., Pinelli, M., Acquaviva, F., Confetto, S., Pelliccia, C., Cocca, A., and Prisco, F.

Published
2012

36. A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity

Author

Frayling, T, Lindgren, C, Chevre, J, Menzel, S, Wishart, M, Benmezroua, Y, Brown, A, Evans, J, Rao, P, Dina, C, Lecoeur, C, Kanninen, T, Almgren, P, Bulman, M, Wang, Y, Mills, J, Wright-Pascoe, R, Mahtani, M, Prisco, F, Costa, A, Cognet, I, Hansen, T, Pedersen, O, Ellard, S, and Tuomi, T

Abstract

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non-insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15-20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identification of new MODY genes. This will potentially enable further dissection of clinical heterogeneity and bring new insights into mechanisms of beta-cell dysfunction. To facilitate the identification of novel MODY loci, we combined the results from three genome-wide scans on a total of 23 families fitting MODY criteria. We used both a strict parametric model of inheritance with heterogeneity and a model-free analysis. We did not identify any single novel locus but provided putative evidence for linkage to chromosomes 6 (nonparametric linkage [NPL]score 2.12 at 71 cM) and 10 (NPL score 1.88 at 169-175 cM), and to chromosomes 3 (heterogeneity LOD [HLOD] score 1.27 at 124 cM) and 5 (HLOD score 1.22 at 175 cM) in 14 more strictly defined families. Our results provide evidence for further heterogeneity in MODY.

Published
2016

37. Epidemiologia della chetoacidosi diabetica in Italia

Author

Cherubini, Valentino, Gesuita, R., Sternardi, S., Ferrito, L., Lenzi, L., Iannilli, A., Piccini, B., Skrami, E., Nicolucci, A., Pintaudi, B., Toni, S., Lera, R., De Luna, L., Kienberger, B., Gualtieri, A., Zecchino, C., Piccino, E., Ortolani, F., Zucchini, S., Maltoni, G., Pasquino, B., Reinstadler, P., Prandi, E., Zattoni, V., Gallo, F., Morganti, G., Guerraggio, L., Ripoli, C., Frongia, M., Pusceddu, P., La Loggia, A., Scanu, P., Cardinale, G., Ponzi, G., Tomaselli, L. G., Rapisarda, V., Citriniti, F., Soprani, T., Tumini, S., Lazzaro, N., De Donno, V., Banin, P., Mainetti, B., Coccioli, M. S., D'Annunzio, G., Minuto, N., Montani, E., Maccioni, R., Marongiu, U., Beccaria, L., Bruzzese, M., Mammì, F., Pardi, D., Lombardo, F., Ventrici, C., Scaramazza, A., Ferrari, M., Bonfanti, R., Rigamonti, A., Iughetti, Lorenzo, Predieri, Barbara, Iafusco, D., Confetto, S., Zanfardino, A., Prisco, F., Franzese, A., De Nitto, E., Cadario, F., Milia, A., Piredda, G., Mereu, L., Soro, M., Correddu, A., Pipia, A., Monciotti, C., Cardella, F., De Berardinis, F., Santoro, G., Chiari, G., Berioli, M. G., Federico, G., Zanette, G., Marsciani, A., Pedini, A., Patera, I. P., Schiaffini, R., Bitti, M., Lidano, R., Pietrosanti, S., Delvecchio, M., Trada, M., Marinaro, A., Meloni, G., Galero, A., Fichera, G., Bulciolu, P., Rabbone, I., Ignaccolo, G., Cauvin, V., Franceschi, R., Faleschini, E., Tornese, G., Salvatoni, A., Cardani, R., Maffeis, C., Marigliano, M., Sabbion, A., Arnaldi, C., Cherubini, Valentino, Gesuita, R., Sternardi, S., Ferrito, L., Lenzi, L., Iannilli, A., Piccini, B., Skrami, E., Nicolucci, A., Pintaudi, B., Toni, S., Lera, R., De Luna, L., Kienberger, B., Gualtieri, A., Zecchino, C., Piccino, E., Ortolani, F., Zucchini, S., Maltoni, G., Pasquino, B., Reinstadler, P., Prandi, E., Zattoni, V., Gallo, F., Morganti, G., Guerraggio, L., Ripoli, C., Frongia, M., Pusceddu, P., La Loggia, A., Scanu, P., Cardinale, G., Ponzi, G., Tomaselli, L. G., Rapisarda, V., Citriniti, F., Soprani, T., Tumini, S., Lazzaro, N., De Donno, V., Banin, P., Mainetti, B., Coccioli, M. S., D'Annunzio, G., Minuto, N., Montani, E., Maccioni, R., Marongiu, U., Beccaria, L., Bruzzese, M., Mammì, F., Pardi, D., Lombardo, F., Ventrici, C., Scaramazza, A., Ferrari, M., Bonfanti, R., Rigamonti, A., Iughetti, L., Predieri, B., Iafusco, Dario, Confetto, S., Zanfardino, A., Prisco, F., Franzese, A., De Nitto, E., Cadario, F., Milia, A., Piredda, G., Mereu, L., Soro, M., Correddu, A., Pipia, A., Monciotti, C., Cardella, F., De Berardinis, F., Santoro, G., Chiari, G., Berioli, M. G., Federico, G., Zanette, G., Marsciani, A., Pedini, A., Patera, I. P., Schiaffini, R., Bitti, M., Lidano, R., Pietrosanti, S., Delvecchio, M., Trada, M., Marinaro, A., Meloni, G., Galero, A., Fichera, G., Bulciolu, P., Rabbone, I., Ignaccolo, G., Cauvin, V., Franceschi, R., Faleschini, E., Tornese, G., Salvatoni, A., Cardani, R., Maffeis, C., Marigliano, M., Sabbion, A., and Arnaldi, C.

Subjects
endocrine system diseases, Type 1 diabete, Endocrinology, Diabetes and Metabolism, nutritional and metabolic diseases, Risk of complication, Diabetes and Metabolism, Type 1 diabetes, Nation-wide retrospective observational study, Endocrinology, Risk factors, Diabetic ketoacidosis, Children, Internal Medicine, Diabetic ketoacidosi, Risk factor
Abstract

Ketoacidosis is a potentially life-threatening complication in patients with type 1 diabetes mellitus (T1DM), particularly children. If diabetic ketoacidosis (DKA) is diagnosed late, the child risks cerebral edema, permanent neurological damage or even death. There have been only few studies of DKA in Italy.From January-May 2014 a nation-wide observational, retrospective study of DKA at diabetes onset was done by the Pediatric Diabetology Study Group (PDSG) of the Italian Society of Pediatric Endocrinology and Diabetes (ISPED), involving 76 Italian centers. DKA was defined using ISPAD criteria; 7457 new cases of T1DM were recruited from mainland Italy and the island of Sicily and 770 from Sardinia, in the period 2004-2013. On the mainland and in Sicily, DKA at diabetes onset was about 32.9% (95% CI 31.8-34.0%), and there was 6.6% (95% CI 6.02-7.20%) of the severe form. Mild and severe DKA risk was significantly higher in children aged 0-4 years; no significant temporal trend was found in the study period. Patients living in Sardinia or having a firstdegree relative with T1DM were at significantly lower risk of DKA at diabetes onset. In the ten-year study period three children died of DKA at onset and four suffered permanent neurological lesions. From November 2011-April 2012 the PDSG conducted a retrospective study based on a sample of 2025 patients with T1DM, aged 0-18 years, involving 29 national centers for pediatric diabetes. The incidence of DKA was 2.4% (IC 95% 1.8-3.1), with children older than ten years at significantly higher risk, probably due to shortages of insulin. Multiple analysis showed a higher risk of DKA in those using a rapid-acting insulin analog and in those with high HbA1c. Young mothers and low levels of education were also associated with DKA.In conclusion, although a wide network of specialized home pediatricians and pediatric diabetes centers is spread across the country, the incidence of DKA at diabetes onset is still high. Further social and health-system efforts are needed to boost awareness of this risk and to reduce damages and costs related to the complication.

Published
2014

38. Indagini geochimiche nell’acquedotto Vergine antico

Author

TUCCIMEI, Paola, Castelluccio M, De Simone G, Lucchetti C, Placidi M, Prisco F, Ursino V., Tuccimei, P, Castelluccio, M, DE SIMONE, Gabriele, Lucchetti, C, Placidi, M, Prisco, F, Ursino, V., Tuccimei, Paola, and De Simone, G

Published
2014

39. Dieci domande su: Sindrome metabolica e diabete mellito di tipo 2 dell’adolescente

Author

IAFUSCO, Dario, Cardella, F., Prisco, F., Iafusco, Dario, Cardella, F., and Prisco, F.

Subjects
Type 2 diabetes mellitu, Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine, Metabolic syndrome
Abstract

The prevalence and magnitude of childhood obesity are increasing dramatically around the world, including Europe and Mediterranean countries such as Italy which seemed somehow to be protected by their eating habits and cultural factors. Obesity plays an important pathogenic role in the metabolic syndrome and in type 2 diabetes in adolescents; this latter was virtually unknown in Italy until a few years ago. Here we briefly describe the pathogenesis and treatment of metabolic syndrome and type 2 diabetes mellitus in children and adolescents, and also present original data collected during a survey by the ISPED National Study Group on Diabetes on the phenotypic characteristics of the first cases of type 2 diabetes mellitus in adolescents in Italy.

Published
2014

40. Erratum: Organization and regional distribution of centers for the management of children and adolescents with diabetes in Italy (Ital J Pediatr (2015) 41 (74) DOI:10.1186/s13052-015-0179-6)

Author

Giorgetti, C., Ferrito, L., Zallocco, F., Iannilli, A., Cherubini, V., Maghnie, M., Rabbone, I., Lera, R., De Luna, L., Kienberger, B., Gualtieri, A., Zecchino, C., Piccino, E., Ortolani, F., Zucchini, S., Maltoni, G., Pasquino, B., Reinstadler, P., Prandi, E., Zattoni, V., Gallo, F., Morganti, G., Guerraggio, L., Ripoli, C., Frongia, M., Pusceddu, P., La Loggia, A., Scanu, P., Cardinale, G., Ponzi, G., Tomaselli, L. G., Rapisarda, V., Citriniti, F., Soprani, T., Tumini, S., Lazzaro, N., De Donno, V., Banin, P., Toni, S., Lenzi, L., Mainetti, B., Coccioli, M. S., D(')Annunzio, G., Minuto, N., Montani, E., Maccioni, R., Marongiu, U., Beccaria, L., Bruzzese, M., Mamm(`i), F., Pardi, D., Lombardo, F., Ventrici, C., Scaramazza, A., Ferrari, M., Bonfanti, R., Rigamonti, A., Iughetti, L., Predieri, B., Iafusco, D., Confetto, S., Zanfardino, A., Prisco, F., Francese, A., De Nitto, E., Cadario, F., Milia, A., Piredda, G., Mereu, L., Soro, M., Correddu, A., Pipia, A., Monciotti, C., Cardella, F., De Berardinis, F., Santoro, G., Chiari, G., Berioli, M. G., Federico, G., Zanette, G., Marsciani, A., Pedini, A., Patera, I. P., Schiaffini, R., Bitti, M., Lidano, R., Pietrosanti, S., Delvecchio, M., Trada, M., Marinaro, A., Meloni, G., Gaiero, A., Fichera, G., Bulciolu, P., Ignaccolo, G., Cauvin, V., Franceschi, R., Faleschini, E., Tornese, G., Salvatoni, A., Cardani, R., Maffeis, C., Marigliano, M., Sabbion, A., and Arnaldi, C.

Subjects
children, type 1 diabetes, children, adolescents, adolescents
Published
2016

42. Permanent diabetes mellitus in the first year of life

Author

Iafusco, D., Stazi, M., Cotichini, R., Cotellessa, M., Martinucci, M., Mazzella, M., Cherubini, V., Barbetti, F., Martinetti, M., Cerutti, F., Prisco, F., and and the Early Onset Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetology

Published
2003
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46. Risultati di una indagine sierologica sulla neosporosi in asini del Sud Italia

Author

VENEZIANO, VINCENZO, PIANTEDOSI, DIEGO, Mariani U., Fusco G., Di Prisco F., D'Alessio N., Guarino A., Santoro M., Sedlak K., Machacova T., Bartova E., Veneziano, Vincenzo, Mariani, U., Fusco, G., Di Prisco, F., D'Alessio, N., Guarino, A., Santoro, M., Piantedosi, Diego, Sedlak, K., Machacova, T., and Bartova, E.

Subjects
Italy, Neospora, donkey
Published
2013

47. Identification of candidate children for maturity-onset diabetes of the young type 2 (MODY2) gene testing: a seven-item clinical flowchart (7-iF)

Author

Pinelli M, Acquaviva F, Barbetti F, Caredda E, Cocozza S, Delvecchio M, Mozzillo E, Pirozzi D, Prisco F, Rabbone I, Sacchetti L, Tinto N, Toni S, Zucchini S, Italian Study Group on Diabetes of the Italian Society of Pediatric Endocrinology, Diabetology, IAFUSCO, Dario, Pinelli, M, Acquaviva, F, Barbetti, F, Caredda, E, Cocozza, S, Delvecchio, M, Mozzillo, E, Pirozzi, D, Prisco, F, Rabbone, I, Sacchetti, L, Tinto, N, Toni, S, Zucchini, S, Iafusco, Dario, Italian Study Group on Diabetes of the Italian Society of Pediatric, Endocrinology, and Diabetology

Abstract

MODY2 is the most prevalent monogenic form of diabetes in Italy with an estimated prevalence of about 0.5–1.5%. MODY2 is potentially indistinguishable from other forms of diabetes, however, its identification impacts on patients’ quality of life and healthcare resources. Unfortunately, DNA direct sequencing as diagnostic test is not readily accessible and expensive. In addition current guidelines, aiming to establish when the test should be performed, proved a poor detection rate. Aim of this study is to propose a reliable and easy-to-use tool to identify candidate patients for MODY2 genetic testing. We designed and validated a diagnostic flowchart in the attempt to improve the detection rate and to increase the number of properly requested tests. The flowchart, called 7-iF, consists of 7 binary ‘‘yes or no’’ questions and its unequivocal output is an indication for whether testing or not. We tested the 7-iF to estimate its clinical utility in comparison to the clinical suspicion alone. The 7-iF, in a prospective 2-year study (921 diabetic children) showed a precision of about the 76%. Using retrospective data, the 7-iF showed a precision in identifying MODY2 patients of about 80% compared to the 40% of the clinical suspicion. On the other hand, despite a relatively high number of missing MODY2 patients, the 7-iF would not suggest the test for 90% of the non-MODY2 patients, demonstrating that a wide application of this method might 1) help less experienced clinicians in suspecting MODY2 patients and 2) reducing the number of unnecessary tests. With the 7-iF, a clinician can feel confident of identifying a potential case of MODY2 and suggest the molecular test without fear of wasting time and money. A Qaly-type analysis estimated an increase in the patients’ quality of life and savings for the health care system of about 9 million euros per year.

Published
2013

48. Microinfusore in adolescenti: 'Cool' o 'Trash'?

Author

Zanfardino, A., Prisco, F., Forgione, E., Picariello, S., Caredda, E., Lancuba, M., IAFUSCO, Dario, Zanfardino, A., Prisco, F., Forgione, E., Picariello, S., Caredda, E., Lancuba, M., and Iafusco, Dario

Subjects
Quality of life, Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine, Insulin pump
Abstract

The so-called "Italian approach" to prescribing an insulin pump, according to the recommendations of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED), stresses the importance of correctly selecting patients so as to avoid dropouts from therapy. We employed the double-interview technique, often used in television shows, asking two adolescents with different opinions on the pump the same questions so we could compare their replies. We hoped this would help understanding the advantages and disadvantages better, but also the prejudices and beliefs about this therapy. Young people are used to defining the appeal of an event as either "cool" or "trash" so we called the girl who is satisfied with the pump "cool" and the one who isn't "trash".

Published
2013

50. Diabete tipo 1, tipo 2 e tipo X. Ipeglicemia in età pediatrica: quale diabete ?

Author

Iafusco, D, Barbetti, F, Massimi, A, Grasso, V, Rabbone, I, Casaburo, F, Cocca, A, Confetto, S, Galderisi, A, Paccone, A, Picariello, S, Piscopo, A, Russo, L, Villano, P, Zanfardino, A, Prisco, F, Tinto, N, Mazzaccara, C, Pirozzi, D, De Sanctis, P, Pinelli, M, Acquaviva, F, and Sacchetti, L

Subjects
Settore MED/13, Settore MED/03
Published
2015

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