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1. Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Author

Adès, J, Alezrah, C, Amado, I, Amar, G, Andréi, O, Arbault, D, Archambault, G, Aurifeuille, G, Barrière, S, Béra-Potelle, C, Blumenstock, Y, Bardou, H, Bareil-Guérin, M, Barrau, P, Barrouillet, C, Baup, E, Bazin, N, Beaufils, B, Ben Ayed, J, Benoit, M, Benyacoub, K, Bichet, T, Blanadet, F, Blanc, O, Blanc-Comiti, J, Boussiron, D, Bouysse, AM, Brochard, A, Brochart, O, Bucheron, B, Cabot, M, Camus, V, Chabannes, JM, Charlot, V, Charpeaud, T, Clad-Mor, C, Combes, C, Comisu, M, Cordier, B, Costi, F, Courcelles, JP, Creixell, M, Cuche, H, Cuervo-Lombard, C, Dammak, A, Da Rin, D, Denis, JB, Denizot, H, Deperthuis, A, Diers, E, Dirami, S, Donneau, D, Dreano, P, Dubertret, C, Duprat, E, Duthoit, D, Fernandez, C, Fonfrede, P, Freitas, N, Gasnier, P, Gauillard, J, Getten, F, Gierski, F, Godart, F, Gourevitch, R, Grassin Delyle, A, Gremion, J, Gres, H, Griner, V, Guerin-Langlois, C, Guggiari, C, Guillin, O, Hadaoui, H, Haffen, E, Hanon, C, Haouzir, S, Hazif-Thomas, C, Heron, A, Hubsch, B, Jalenques, I, Januel, D, Kaladjian, A, Karnycheff, JF, Kebir, O, Krebs, MO, Lajugie, C, Leboyer, M, Legrand, P, Lejoyeux, M, Lemaire, V, Leroy, E, Levy-Chavagnat, D, Leydier, A, Liling, C, Llorca, PM, Loeffel, P, Louville, P, Lucas Navarro, S, Mages, N, Mahi, M, Maillet, O, Manetti, A, Martelli, C, Martin, P, Masson, M, Maurs-Ferrer, I, Mauvieux, J, Mazmanian, S, Mechin, E, Mekaoui, L, Meniai, M, Metton, A, Mihoubi, A, Miron, M, Mora, G, Niro Adès, V, Nubukpo, P, Omnes, C, Papin, S, Paris, P, Passerieux, C, Pellerin, J, Perlbarg, J, Perron, S, Petit, A, Petitjean, F, Portefaix, C, Pringuey, D, Radtchenko, A, Rahiou, H, Raucher-Chéné, D, Rauzy, A, Reinheimer, L, Renard, M, René, M, Rengade, CE, Reynaud, P, Robin, D, Rodrigues, C, Rollet, A, Rondepierre, F, Rousselot, B, Rubingher, S, Saba, G, Salvarelli, JP, Samuelian, JC, Scemama-Ammar, C, Schurhoff, F, Schuster, JP, Sechter, D, Segalas, B, Seguret, T, Seigneurie, AS, Semmak, A, Slama, F, Taisne, S, Taleb, M, Terra, JL, Thefenne, D, Tran, E, Tourtauchaux, R, Vacheron, MN, Vandel, P, Vanhoucke, V, Venet, E, Verdoux, H, Viala, A, Vidon, G, Vitre, M, Vurpas, JL, Wagermez, C, Walter, M, Yon, L, Zendjidjian, X., Morlet, Elise, Costemale-Lacoste, Jean-François, Poulet, Emmanuel, McMahon, Kibby, Hoertel, Nicolas, and Limosin, Frédéric

Published
2019
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2. Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

Author

Adès, J., Alezrah, C., Amado, I., Amar, G., Andréi, O., Arbault, D., Archambault, G., Aurifeuille, G., Barrière, S., Béra-Potelle, C., Blumenstock, Y., Bardou, H., Bareil-Guérin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A.M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V., Chabannes, J.M., Charlot, V., Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J.P., Creixell, M., Cuche, H., Cuervo-Lombard, C., Dammak, A., Da Rin, D., Denis, J.B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., Dreano, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, F., Godart, F., Gourevitch, R., Grassin Delyle, A., Gremion, J., Gres, H., Griner, V., Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Hanon, C., Haouzir, S., Hazif-Thomas, C., Heron, A., Hoertel, N., Hubsch, B., Jalenques, I., Januel, D., Kaladjian, A., Karnycheff, J.F., Kebir, O., Krebs, M.O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V., Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Limosin, F., Llorca, P.M., Loeffel, P., Louville, P., Lucas Navarro, S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I., Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., Mora, G., Niro Adès, V., Nubukpo, P., Omnes, C., Papin, S., Paris, P., Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Portefaix, C., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chéné, D., Rauzy, A., Reinheimer, L., Renard, M., René, M., Rengade, C.E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J.P., Samuelian, J.C., Scemama-Ammar, C., Schurhoff, F., Schuster, J.P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A.S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J.L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M.N., Vandel, P., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J.L., Wagermez, C., Walter, M., Yon, L., Zendjidjian, X., Pascal de Raykeer, Rachel, Hoertel, Nicolas, Blanco, Carlos, Lavaud, Pierre, Kaladjian, Arthur, Blumenstock, Yvonne, Cuervo-Lombard, Christine-Vanessa, Peyre, Hugo, Lemogne, Cédric, and Limosin, Frédéric

Published
2019
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5. Late-onset and nonlate-onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Author

Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Portefaix, C., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chene, D., Rauzy, A., Reinheimer, L., Renard, M., Rene, M., Rengade, C. E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J. P., Samuelian, J. C., Scemama-Ammar, C., Schurhoff, F., Schuster, J. P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A. S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J. L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M. N., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J. L., Wagermez, C., Walter, M., Zendjidjian, X., Abou Kassm, Sandra, Limosin, Frederic, Naja, Wadih, Vandel, Pierre, Sanchez-Rico, Marina, Alvarado, Jesus M., Gunten, Armin, Hoertel, Nicolas, Ades, J., Alezrah, C., Amado, I, Amar, G., Andrei, O., Arbault, D., Archambault, G., Aurifeuille, G., Barriere, S., Bera-Potelle, C., Blumenstock, Y., Bardou, H., Bareil-Guerin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A. M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V, Chabannes, J. M., Charlot, V, Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J. P., Creixell, M., Cuche, H., Cuervo-Lombard, C., Dammak, A., da Rin, D., Denis, J. B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., Dreano, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, Fabien, Godart, F., Gourevitch, R., Delyle, Grassin A., Gremion, J., Gres, H., Griner, V, Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Haouzir, S., Hanon, C., Hazif-Thomas, C., Heron, A., Hubsch, B., Jalenques, I, Januel, D., Kaladjian, A., Karnycheff, J. F., Kebir, O., Krebs, M. O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V, Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Llorca, P. M., Loeffel, P., Louville, P., Navarro, Lucas S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I, Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., Mora, G., Ades, Niro, Nubukpo, P., Omnes, C., Papin, S., Paris, P., Fondation FondaMental [Créteil], Weizenbaum Institut [Berlin], Monash University [Clayton], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Cognition, Santé, Société (C2S), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Department of Engineering Cybernetics [Trondheim] (ITK NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Agence nationale de la sécurité des systèmes d'information (ANSSI), Jeune Equipe Hémopathogènes Vectorisés, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Research Center for Biosciences and Health Technologies [Lisboa] (CBIOS), Universidade Lusófona's, PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX (PHENIX), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Modélisation de la matière condensée et des interfaces (MMCI), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Kantar – Health Division, Partenaires INRAE, Institut National de la Santé et de la Recherche Médicale (INSERM), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut de biologie et chimie des protéines [Lyon] (IBCP), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale (EA7479 SPURBO), Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Service de Psychiatrie, Hôpital de la Conception, Piici, UMR 7298, Aix-Marseille Université-CNRS, Marseille, France, Hôpital Corentin Celton [Issy-les-Moulineaux], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Département de psychiatrie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), PELLENC S.A., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS), French Society for Biological Psychiatry and Neuropsychopharmacology, CHU Clermont-Ferrand, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Hôpital Foch [Suresnes], Università degli studi di Genova = University of Genoa (UniGe), Unité de recherche Mathématiques et Informatique Appliquées (MIA), Institut National de la Recherche Agronomique (INRA), Fédération Française de Triathlon (FFTRI), AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, DMU ESPRIT, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Colombes, Inserm U1266, 178, rue des Renouillers, 92700 Colombes, France, UFR de Médecine Paris Nord, Université de Paris, 16, rue Henri Huchard, 75018 Paris, France., Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service hospitalo-universitaire, centre hospitalier du Rouvray, 4, rue Paul-Eluard, 76300 Sotteville-lès-Rouen, France., CHRU Brest - Psychiatrie Adulte (CHU - Brest- Psychiatrie), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Laboratoire de Physique des Lasers (LPL), Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), Groupement de recherche en Psychiatrie (GDR Psychiatrie (3557)), Centre National de la Recherche Scientifique (CNRS), Université Paris Cité (UPCité), Synchrotron SOLEIL (SSOLEIL), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), Hôpital Paul Brousse, Digitéo, Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), RiverLy - Fonctionnement des hydrosystèmes (RiverLy), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sonatrach Exploration, and Centre Hospitalier Victor Jousselin de Dreux

Subjects
Psychosis, Pediatrics, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], Late onset, Schizoaffective disorder, Comorbidity, Odds ratio, medicine.disease, Psychiatry and Mental health, Cross-Sectional Studies, Psychotic Disorders, Quality of life, Schizophrenia, Quality of Life, medicine, Humans, Geriatrics and Gerontology, business, Aged, Diagnosis of schizophrenia
Abstract

International audience; Objectives Data are scarce regarding the potential clinical differences between non-late onset schizophrenia (NLOS, i.e., disorder occurring before 40 years of age), late-onset schizophrenia (LOS, occurring between ages 40 and 60 years) and very-late-onset schizophrenia-like psychosis (VLOSLP, occurring after 60 years of age). Furthermore, previous research compared LOS patients with non-age matched NLOS patients. In this study, we sought to examine potential clinical differences between patients of similar age with LOS and NLOS. Methods/Design This is a cross-sectional multicentre study that recruited in- and outpatients older adults (aged >= 55 years) with an ICD-10 diagnosis of schizophrenia or schizoaffective disorder with NLOS and LOS. Sociodemographic and clinical characteristics, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization were drawn for comparison. Results Two hundred seventy-two participants (79.8%) had NLOS, 61 (17.9%) LOS, and 8 (2.3%) VLOSLP. LOS was significantly and independently associated with greater severity of emotional withdrawal and lower severity of depression (all p < 0.05). However, the magnitude of these associations was modest, with significant adjusted odds ratios ranging from 0.71 to 1.24, and there were no significant between-group differences in other characteristics. Conclusion In an age-matched multicenter sample of elderly patients with schizophrenia, older adults with LOS were largely similar to older adults with NLOS in terms of clinical characteristics. The few differences observed may be at least partially related to symptom fluctuation with time. Implications of these findings for pharmacological and nonpharmacological management is yet to be determined.

Published
2021

8. Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Author

Morlet, Elise, primary, Costemale-Lacoste, Jean-François, additional, Poulet, Emmanuel, additional, McMahon, Kibby, additional, Hoertel, Nicolas, additional, Limosin, Frédéric, additional, Adès, J, additional, Alezrah, C, additional, Amado, I, additional, Amar, G, additional, Andréi, O, additional, Arbault, D, additional, Archambault, G, additional, Aurifeuille, G, additional, Barrière, S, additional, Béra-Potelle, C, additional, Blumenstock, Y, additional, Bardou, H, additional, Bareil-Guérin, M, additional, Barrau, P, additional, Barrouillet, C, additional, Baup, E, additional, Bazin, N, additional, Beaufils, B, additional, Ben Ayed, J, additional, Benoit, M, additional, Benyacoub, K, additional, Bichet, T, additional, Blanadet, F, additional, Blanc, O, additional, Blanc-Comiti, J, additional, Boussiron, D, additional, Bouysse, AM, additional, Brochard, A, additional, Brochart, O, additional, Bucheron, B, additional, Cabot, M, additional, Camus, V, additional, Chabannes, JM, additional, Charlot, V, additional, Charpeaud, T, additional, Clad-Mor, C, additional, Combes, C, additional, Comisu, M, additional, Cordier, B, additional, Costi, F, additional, Courcelles, JP, additional, Creixell, M, additional, Cuche, H, additional, Cuervo-Lombard, C, additional, Dammak, A, additional, Da Rin, D, additional, Denis, JB, additional, Denizot, H, additional, Deperthuis, A, additional, Diers, E, additional, Dirami, S, additional, Donneau, D, additional, Dreano, P, additional, Dubertret, C, additional, Duprat, E, additional, Duthoit, D, additional, Fernandez, C, additional, Fonfrede, P, additional, Freitas, N, additional, Gasnier, P, additional, Gauillard, J, additional, Getten, F, additional, Gierski, F, additional, Godart, F, additional, Gourevitch, R, additional, Grassin Delyle, A, additional, Gremion, J, additional, Gres, H, additional, Griner, V, additional, Guerin-Langlois, C, additional, Guggiari, C, additional, Guillin, O, additional, Hadaoui, H, additional, Haffen, E, additional, Hanon, C, additional, Haouzir, S, additional, Hazif-Thomas, C, additional, Heron, A, additional, Hubsch, B, additional, Jalenques, I, additional, Januel, D, additional, Kaladjian, A, additional, Karnycheff, JF, additional, Kebir, O, additional, Krebs, MO, additional, Lajugie, C, additional, Leboyer, M, additional, Legrand, P, additional, Lejoyeux, M, additional, Lemaire, V, additional, Leroy, E, additional, Levy-Chavagnat, D, additional, Leydier, A, additional, Liling, C, additional, Llorca, PM, additional, Loeffel, P, additional, Louville, P, additional, Lucas Navarro, S, additional, Mages, N, additional, Mahi, M, additional, Maillet, O, additional, Manetti, A, additional, Martelli, C, additional, Martin, P, additional, Masson, M, additional, Maurs-Ferrer, I, additional, Mauvieux, J, additional, Mazmanian, S, additional, Mechin, E, additional, Mekaoui, L, additional, Meniai, M, additional, Metton, A, additional, Mihoubi, A, additional, Miron, M, additional, Mora, G, additional, Niro Adès, V, additional, Nubukpo, P, additional, Omnes, C, additional, Papin, S, additional, Paris, P, additional, Passerieux, C, additional, Pellerin, J, additional, Perlbarg, J, additional, Perron, S, additional, Petit, A, additional, Petitjean, F, additional, Portefaix, C, additional, Pringuey, D, additional, Radtchenko, A, additional, Rahiou, H, additional, Raucher-Chéné, D, additional, Rauzy, A, additional, Reinheimer, L, additional, Renard, M, additional, René, M, additional, Rengade, CE, additional, Reynaud, P, additional, Robin, D, additional, Rodrigues, C, additional, Rollet, A, additional, Rondepierre, F, additional, Rousselot, B, additional, Rubingher, S, additional, Saba, G, additional, Salvarelli, JP, additional, Samuelian, JC, additional, Scemama-Ammar, C, additional, Schurhoff, F, additional, Schuster, JP, additional, Sechter, D, additional, Segalas, B, additional, Seguret, T, additional, Seigneurie, AS, additional, Semmak, A, additional, Slama, F, additional, Taisne, S, additional, Taleb, M, additional, Terra, JL, additional, Thefenne, D, additional, Tran, E, additional, Tourtauchaux, R, additional, Vacheron, MN, additional, Vandel, P, additional, Vanhoucke, V, additional, Venet, E, additional, Verdoux, H, additional, Viala, A, additional, Vidon, G, additional, Vitre, M, additional, Vurpas, JL, additional, Wagermez, C, additional, Walter, M, additional, Yon, L, additional, and Zendjidjian, X., additional

Published
2019
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11. Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study

Author

Pascal de Raykeer, Rachel, Hoertel, Nicolas, Blanco, Carlos, Lavaud, Pierre, Kaladjian, Arthur, Blumenstock, Yvonne, Cuervo-Lombard, Christine-Vanessa, Peyre, Hugo, Lemogne, Cédric, Limosin, Frédéric, Portefaix, C., Adès, J., Alezrah, C., Amado, I., Amar, G., Andréi, O., Arbault, D., Archambault, G., Aurifeuille, G., Barrière, S., Béra-Potelle, C., Bardou, H., Bareil-Guérin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A.M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V., Chabannes, J.M., Charlot, V., Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J.P., Creixell, M., Cuche, H., Dammak, A., Da Rin, D., Denis, J.B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., DREANO, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, F., Godart, F., Gourevitch, R., Grassin Delyle, A., Gremion, J., Gres, H., Griner, V., Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Hanon, Cécile, Haouzir, S., Hazif-Thomas, C., Heron, A., Hubsch, B., Jalenques, I., Januel, D., Karnycheff, J.F., Kebir, O., Krebs, M.O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V., Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Llorca, P.M., Loeffel, P., Louville, P., Lucas Navarro, S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I., Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., MORA, G., Niro Adès, V., Nubukpo, P., Omnes, C., Papin, S., Paris, P., Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chéné, D., Rauzy, A., Reinheimer, L., Renard, M., René, M., Rengade, C.E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J.P., Samuelian, J.C., Scemama-Ammar, C., Schurhoff, F., Schuster, J.P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A.S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J.L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M.N., Vandel, P., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J.L., Wagermez, C., Walter, M., Yon, L., Zendjidjian, X., Rotenberg, Léa, Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Department of Radiology, Maison Blanche Hospital, Université Reims-Champagne-Ardenne, 45, rue Cognacq-Jay, 51092 Reims, France, and Centre Hospitalier Universitaire de Reims (CHU Reims)

Subjects
Male, medicine.medical_specialty, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Population, Psychological intervention, Schizoaffective disorder, Psychiatric Department, Hospital, Neuropsychological Tests, 03 medical and health sciences, 0302 clinical medicine, Quality of life, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Brief Psychiatric Rating Scale, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Pharmacology (medical), Cognitive Dysfunction, education, Psychiatry, Biological Psychiatry, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, education.field_of_study, business.industry, General Medicine, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Cohort, Disease Progression, Quality of Life, Female, France, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Psychopathology, Follow-Up Studies
Abstract

The severity of psychopathology has a strong negative impact on quality of life (QoL) among older adults with schizophrenia spectrum disorder. However, because these subjects generally experience multiple psychiatric symptoms, it remains unclear whether decreased QoL in this population is due to specific symptoms (e.g., hallucinations), specific dimensions of psychopathology (e.g., negative symptoms), a general psychopathology dimension representing the shared effect across all psychiatric symptoms, or a combination of these explanations. Data were derived from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) study, a large (N = 353) multicenter sample of older adults with schizophrenia spectrum disorder recruited from French public-sector psychiatric departments. We used structural equation modeling to examine the shared and specific effects of psychiatric symptoms on QoL, while adjusting for sociodemographic characteristics, general medical conditions, global cognitive functioning and psychotropic medications. Psychiatric symptoms and QoL were assessed face-to-face by psychiatrists using the Brief Psychiatric Rating Scale (BPRS) and the Quality of Life Scale (QLS). Among older adults with schizophrenia spectrum disorder, effects of psychiatric symptoms on QoL were exerted mostly through a general psychopathology dimension (β = − 0.43, p

Published
2018

12. Royal academy of medicine in Ireland international conference on homocysteine metabolism from basic science to clinical medicine: Proceedings of meeting held at Dromoland Castle, Co. Clare on July 2nd–6th, 1995

Author

Björkegren, K., Bergmark, C., de Faire, U., Mansoor, M. Azam, Svardal, A., Bostom, A. G., Roubenoff, R., Dellaripa, P., Nadeau, M. R., Sutherland, P., Wilson, P. W. F., Jacques, P. F., Selhub, J., Rosenberg, I. H., Bostom, A. G., Brosnan, J. T., Hall, B., Nadeau, M. R., Selhub, J., Bostom, A. G., Shemin, D., Lapane, K. L., Sutherland, P., Nadeau, M. R., Wilson, P. W. F., Selhub, J., Bostom, A. G., Shemin, D., Nadeau, M. R., Selhub, J., Bostom, A. G., Selhub, J., Jacques, P. F., Nadeau, M. R., Williams, R. R., Ellison, R. C., Cuskelly, G. J., McNulty, H., Strain, J. J., McPartlin, J. M., Scott, J. M., Chadefaux-Vekemans, B., Coudé, M., Aupetit, J., Kamoun, P., Coudé, M., Aral, B., Zabot, M. T., Aupetit, J., Kamoun, P., Chadefaux-Vekemans, B., Calaf, R., Ghiringelli, O., Barlatier, A., Charpiot, P., Rolland, P. H., Garçon, D., Charpiot, P., Augier, T., Chareyre, C., Rolland, P. H., Garçon, D., Chango, A., Hodez, F., Tronel, H., Nuel, G., Michel, F., Frémont, S., Méjean, L., Nicolas, J. P., Candito, M., Chambon, P., Gibelin, P., Amsellem, J., Baudouy, M., Morand, P., Candito, M., Chambon, P., Pringuey, D., Aubin-Brunet, V., Beaulieu, F., Darcourt, G., Bedoucha, P., Alchaar, H., Chatel, M., Candito, M., de Valk, H. W., van der Griend, R., Eeden, M. K. G. van, de Groot, E., Duran, M., Smeitink, J. A. M., de Klerk, J. B. C., Wittebol-Post, D., Rolland, M. -O., Haas, F. J. L. M., Meuwissen, O. J. A. Th., Banga, J. D., Poll-The, B. T., de Vries, J. I. P., Dekker, G. A., van Geijn, H. P., Huigens, P. C., Jakobs, C., von Blomberg, B. M. E., Deulofeu, R., Giralt, M., Aibar, C., Bauchet, C., Ballesta, A. M., Varela, G., Vila, N., Chamorro, A., Casals, F. J., Cremades, J. Diaz, Daly, L., Meleady, R., Graham, I., den Heijer, M., Brouwer, I. A., Gerrits, W. B. J., Bos, G. M. J., Blom, H. J., den Heijer, M., Bos, G. M. J., Koster, T., Vandenbroucke, J. P., Blom, H. J., Briët, E., Rosendaal, F. R., Fischer, G., Behrend, C., Bartholmes, P., Fermo, I., Paroni, R., Vigano, S., D’Angelo, A., Fermo, I., Paroni, R., Vigano, S., D’Angelo, A., Franken, D. G., Boers, G. H. J., Blom, H. J., Hamel, B. C. J., Franken, D. G., Boers, G. H. J., Blom, H. J., Ruijs, J. H. J., Franken, D. G., Blom, H. J., Boers, G. H. J., Tangerman, A., Guttormsen, A. B., Ueland, P. M., Refsum, H., Svarstad, E., Gao, W., Goldman, E., Jakubowski, H., Sebastio, G., Sperandeo, M. P., de Franchis, R., Andria, G., Garrow, T. A., Hladovec, J., Sommerova, Z., Písariková, A., Halsted, C. H., Villanueva, J., Chandler, C. J., Stabler, S. P., Allen, R. H., Muskhelishvili, L., James, S. J., Poirer, L., Jacobsen, D. W., Savon, S. R., DiCorleto, P. E., Jourdheuil-Rahmani, D., Rolland, P. H., Garçon, D., Joosten, E., Riezler, R., Allen, R., Joosten, E., Riezler, R., Allen, R., Marquardt, T., Ullrich, K., Harms, E., Koch, H. G., Koch, H. G., Evers, S., Grotemeyer, K. H., Vogelpohl, L., von Eckardstein, A., Ullrich, K., Deufel, T., Kraus, J., Harms, E., Kozich, V., Janosik, M., Sokolová, J., Bukovská, G., Kraus, J. P., Kluitmans, L. A. J., van den Heuvel, L. P., Stevens, E., Trubels, J. M. F., Blom, H. J., Boers, G. H. J., van Oost, B. A., Kraus, J. P., Kittner, S., Macko, R., Hebel, J. R., Rohr, J., Malinow, M. R., Upson, B., Buchholz, D., Earley, C., Johnson, C., Price, T. R., Rosario, J., Sloan, M., Stern, B., Wityk, R., Wozniak, M., Sherwin, R., Stolley, P., Kluijtmans, L., Heuvel, L. van den, Stevens, E., Trijbels, F., Blom, H., Boers, G., van Oost, B., den Heijer, M., Rozen, R., Löhrer, F., Angst, C., Fowler, B., Zaugg, M., Brunner, F., Haefeli, W. E., Nedrebø, B., Ericsson, U. -B., Ueland, P. M., Refsum, H., Lien, E. A., London, J., Paly, E., Paul, V., Paris, D., Kamoun, P., Chassé, J. F., Møller, J., Rasmussen, K., Meleady, R., Graham, I., Daly, L., Verhoef, P., Meleady, R., Graham, I., Daly, L., McMartin, K. E., Phifer, T. J., Alexander, J. S., Middlebrooks, M., Childress, L. E., Nicolas, J. P., Tronel, H., Chango, A., Fremont, S., Felden, F., Guerci, B., Creton, C., Drouin, P., Oakley, G. P., Elias, P. R. P., Hann, A. C., Curtis, C. G., Rose, F. A., Tudball, N., Parrot-Roulaud, F., Cochet, C., Catargi, B., Leprat, F., Latapie, J. -L., Perna, A. F., De Santo, N. G., Ingrosso, D., Galletti, P., Zappia, V., Parrot-Roulaud, F., Sassoust, G., Boissieras, P., Blom, H. J., Majors, A. K., Ehrhart, L. A., Pezacka, E. H., Perry, I. J., Morris, R. W., Ebrahim, S. B., Shaper, A. G., Refsum, H., Ueland, P. M., Pietrzik, K., Dierkes, J., Kroesen, M., Bung, P., Rasmussen, K., Moller, J., Rasmussen, K., Remacha, A., Garcia-Die, F., Cadafalch, J., Barceló, H. J., Parellada, H., Regland, B., Gottfries, C. -G., Andersson, M., Bagby, J., Dyrehag, L. -E., Abrahamsson, L., Ronge, E., Kjellman, B., Frosst, P., Christensen, B., Goyette, P., Rosenblatt, D. S., Genest, J., Rozen, R., Riedel, B., Ueland, P. M., Svardal, A. M., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X. W., Xie, L., Dudman, N., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X. W., Xie, L., Dudman, N., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X., Xie, L., Dudman, N., Smith, B., Kohlman-Trigoboff, D., Simsir, S., Stabler, S. P., Allen, R. H., Strydom, A. J. C., Schlüssel, E., Preibisch, G., Elstner, E. F. E., Pütter, S., Spuijbroek, M. D. E. H., Goddijn-Wessel, T. A. W., Wouters, M. G. A. J., Molen, E. F. v. d., Blom, H. J., Boers, G. H. J., Steegers-Theunissen, R. P. M., Trijbels, J. M. F., Thomas, C. M. G., Eskes, T. K. A. B., Tsai, M. Y., Hanson, N., Key, N., Schwichtenberg, K., Garg, U., Todesco, L., Fowler, B., Pollaert, N., Haefeli, W. E., Thorand, B., Hages, M., Pietrzik, K., Bung, P., Holzgreve, W., Vila, N., Chamorro, A., Deulofeu, R., Aibar, C., Giralt, M., Ballesta, A. M., van der Mooren, M. J., Wouters, M. G. A. J., Schellekens, L. A., Eskes, T. K. A. B., Rolland, R., Blom, H. J., Put, N. v. d., Trijbels, F., Heuvel, L. v. d., Blom, H., Eskes, T., Steegers-Theunissen, R., Mariman, E., Heyer, M. d., Rozen, R., Daher, R., Van Lente, F., Vilkovsky, A. B., Maev, I. V., Richter, E. L., Kirnus, M. D., Varela-Moreiras, G., Alonso-Aperte, E., Rubio, M., Gassó, M., Deulofeu, R., Alvarez, L., Caballeria, J., Rodés, J., Mato, J. M., van Aerts, L. A. G. J. M., Peereboom-Stegeman, J. H. J. Copius, Noordhoek, J., Eskes, T. K. A. B., Molen, E. F. v. d., Spuijbroek, M. D. E. H., Eskes, T. K. A. B., Heuvel, L. P. v. d., Monnens, L. A. H., Blom, H. J., van Guidener, C., Janssen, M. J. F. M., Surachno, J., Stehouwer, C. D. A., van den Berg, M., Bierdrager, E., Rauwerda, J. A., Wilcken, B., Hammond, J., Wouters, M. G. A. J., Hamilton, C. J. C. M., Blom, H. J., Boers, G. H. J., Thomas, C. M. G., Borm, G. F., Eskes, T. K. A. B., Wang, H., Tsai, J. -C., Perrella, M. A., Yoshizumi, M., Sibinga, N. E. S., Haber, E., Chang, T. H. -T., Schlegel, R., Lee, M. -E., Woodside, J., McMaster, D., Yarnell, J., Young, I., Mercer, C., Byrne, K., Evans, A., Gey, F., Gao, X. M., Dougan, G., Wordsworth, P., McMichael, A., Young, P. B., Kennedy, D. G., Molloy, A. M., Scott, J. M., Ward, P., Naughten, E., Cahalane, S., Murphy, D., Mayne, P., Chauveau, P., Chadefaux-Vekemans, B., Coudé, M., Aupetit, J., Kamoun, P., Jungers, P., van Asselt, D. Z. B., Blom, H. J., de Wild, G. M., van Staveren, W. A., Hoefnagels, W. H. L., Naruszewicz, M., Staniewicz, A., Dziewanowski, K., Evrovski, J., Cole, D. E. C., Callaghan, Michael, Lindgren, A., Brattström, L., Hultberg, B., Verhoef, P., Hennekens, C. H., Allen, R. H., Stabler, S. P., Willett, W. C., Stampfer, M. J., Frantzen, F., Sundrehagen, E., Verhoef, P., Kok, F. J., Stampfer, M. J., Willett, W. C., Gaziano, J. M., Hennekens, C. H., Allen, R. H., Stabler, S. P., Reynolds, R. D., Hsu, R. -J., Shane, B., Robinson, K., Kottke-Marchant, K., Green, R., Gupta, A., Jacobsen, D., Robinson, K., Mayer, E., Gupta, A., Miller, D., Marchant, K., Green, R., Jacobsen, D., Greene, R., Chong, Y. -Y., Jacobsen, D., Robinson, K., Gupta, M., Sheppard, C. A., Matthews, R. G., Goyette, P., Frosst, P., Rozen, R., Verhoef, P., Kok, F. J., Kruyssen, H. A. C. M., Witteman, J. C. M., Ueland, P. M., Boushey, C., Beresford, S., Omenn, G., Motulsky, A. G., Nygard, O., Vollset, S. E., Kvale, G., Stensvold, I., Ueland, P. M., Refsum, H., Fiskerstrand, T., Ueland, P. M., Refsum, H., Bugge, K. H., Oshaug, A., Bjønnes, C. H., Refsum, H., Wu, J. T., Wu, L. L., and Wilson, L. W.

Published
1995
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13. Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

Author

Pascal de Raykeer, Rachel, primary, Hoertel, Nicolas, additional, Blanco, Carlos, additional, Lavaud, Pierre, additional, Kaladjian, Arthur, additional, Blumenstock, Yvonne, additional, Cuervo-Lombard, Christine-Vanessa, additional, Peyre, Hugo, additional, Lemogne, Cédric, additional, Limosin, Frédéric, additional, Adès, J., additional, Alezrah, C., additional, Amado, I., additional, Amar, G., additional, Andréi, O., additional, Arbault, D., additional, Archambault, G., additional, Aurifeuille, G., additional, Barrière, S., additional, Béra-Potelle, C., additional, Blumenstock, Y., additional, Bardou, H., additional, Bareil-Guérin, M., additional, Barrau, P., additional, Barrouillet, C., additional, Baup, E., additional, Bazin, N., additional, Beaufils, B., additional, Ben Ayed, J., additional, Benoit, M., additional, Benyacoub, K., additional, Bichet, T., additional, Blanadet, F., additional, Blanc, O., additional, Blanc-Comiti, J., additional, Boussiron, D., additional, Bouysse, A.M., additional, Brochard, A., additional, Brochart, O., additional, Bucheron, B., additional, Cabot, M., additional, Camus, V., additional, Chabannes, J.M., additional, Charlot, V., additional, Charpeaud, T., additional, Clad-Mor, C., additional, Combes, C., additional, Comisu, M., additional, Cordier, B., additional, Costi, F., additional, Courcelles, J.P., additional, Creixell, M., additional, Cuche, H., additional, Cuervo-Lombard, C., additional, Dammak, A., additional, Da Rin, D., additional, Denis, J.B., additional, Denizot, H., additional, Deperthuis, A., additional, Diers, E., additional, Dirami, S., additional, Donneau, D., additional, Dreano, P., additional, Dubertret, C., additional, Duprat, E., additional, Duthoit, D., additional, Fernandez, C., additional, Fonfrede, P., additional, Freitas, N., additional, Gasnier, P., additional, Gauillard, J., additional, Getten, F., additional, Gierski, F., additional, Godart, F., additional, Gourevitch, R., additional, Grassin Delyle, A., additional, Gremion, J., additional, Gres, H., additional, Griner, V., additional, Guerin-Langlois, C., additional, Guggiari, C., additional, Guillin, O., additional, Hadaoui, H., additional, Haffen, E., additional, Hanon, C., additional, Haouzir, S., additional, Hazif-Thomas, C., additional, Heron, A., additional, Hoertel, N., additional, Hubsch, B., additional, Jalenques, I., additional, Januel, D., additional, Kaladjian, A., additional, Karnycheff, J.F., additional, Kebir, O., additional, Krebs, M.O., additional, Lajugie, C., additional, Leboyer, M., additional, Legrand, P., additional, Lejoyeux, M., additional, Lemaire, V., additional, Leroy, E., additional, Levy-Chavagnat, D., additional, Leydier, A., additional, Liling, C., additional, Limosin, F., additional, Llorca, P.M., additional, Loeffel, P., additional, Louville, P., additional, Lucas Navarro, S., additional, Mages, N., additional, Mahi, M., additional, Maillet, O., additional, Manetti, A., additional, Martelli, C., additional, Martin, P., additional, Masson, M., additional, Maurs-Ferrer, I., additional, Mauvieux, J., additional, Mazmanian, S., additional, Mechin, E., additional, Mekaoui, L., additional, Meniai, M., additional, Metton, A., additional, Mihoubi, A., additional, Miron, M., additional, Mora, G., additional, Niro Adès, V., additional, Nubukpo, P., additional, Omnes, C., additional, Papin, S., additional, Paris, P., additional, Passerieux, C., additional, Pellerin, J., additional, Perlbarg, J., additional, Perron, S., additional, Petit, A., additional, Petitjean, F., additional, Portefaix, C., additional, Pringuey, D., additional, Radtchenko, A., additional, Rahiou, H., additional, Raucher-Chéné, D., additional, Rauzy, A., additional, Reinheimer, L., additional, Renard, M., additional, René, M., additional, Rengade, C.E., additional, Reynaud, P., additional, Robin, D., additional, Rodrigues, C., additional, Rollet, A., additional, Rondepierre, F., additional, Rousselot, B., additional, Rubingher, S., additional, Saba, G., additional, Salvarelli, J.P., additional, Samuelian, J.C., additional, Scemama-Ammar, C., additional, Schurhoff, F., additional, Schuster, J.P., additional, Sechter, D., additional, Segalas, B., additional, Seguret, T., additional, Seigneurie, A.S., additional, Semmak, A., additional, Slama, F., additional, Taisne, S., additional, Taleb, M., additional, Terra, J.L., additional, Thefenne, D., additional, Tran, E., additional, Tourtauchaux, R., additional, Vacheron, M.N., additional, Vandel, P., additional, Vanhoucke, V., additional, Venet, E., additional, Verdoux, H., additional, Viala, A., additional, Vidon, G., additional, Vitre, M., additional, Vurpas, J.L., additional, Wagermez, C., additional, Walter, M., additional, Yon, L., additional, and Zendjidjian, X., additional

Published
2019
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19. [Pathophysiological models of mixed states]

Author

Belzeaux, R., Ibrahim, E. C., Azorin, J.-M., Fakra, E., Maurel, M., Pringuey, D., Kaladjian, A., Dassa, D., Corréard, N., Dubois, Emeric, Micoulaud-Franchi, Jean-Arthur, Cermolacce, M., Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, Pôle psychiatrique Centre, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Institut de neurosciences cognitives de la méditerranée - UMR 6193 (INCM), and Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS)

Subjects
Suicide Prevention, Depressive Disorder, Major, Bipolar Disorder, Substance-Related Disorders, Dopamine, Models, Neurological, Brain, Comorbidity, Anxiety Disorders, Personality Disorders, Thyroid Diseases, behavioral disciplines and activities, Diagnostic and Statistical Manual of Mental Disorders, Affect, Suicide, mental disorders, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Arousal, Temperament
Abstract

International audience; Mixed states are complex manifestations of bipolar disorders. Pathophysiology of mixed states remains unclear. Several models have been proposed to understand the mechanisms underlying these mood states. These models describe mixed state either as a combinaison of depression and mania, as well as a transition between mania and depression, or mixed state as a severe type of depression or mania. Pathophysiological hypotheses involve temperaments or some personality disorders, psychiatric comorbidities as well as substance use disorders, or thyroid dysfunction. However, the formal demonstration of any specific genetic vulnerability to mixed state has not yet been provided.

Published
2013

24. Short history of mixed states

Author

Cermolacce, M., Belzeaux, R., Correard, N., Dassa, D., Dubois, M., Micoulaud-Franchi, J. -A, Pringuey, D., Fakra, E., Maurel, M., Azorin, J. -M., Institut de neurosciences cognitives de la méditerranée - UMR 6193 (INCM), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Pôle psychiatrique Centre, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), and Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2

Subjects
[SCCO]Cognitive science, [SCCO.NEUR]Cognitive science/Neuroscience, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2013

39. Modèles physiopathologiques des états mixtes

Author

Belzeaux, R., primary, Ibrahim, E.C., additional, Azorin, J.-M., additional, Fakra, E., additional, Maurel, M., additional, Pringuey, D., additional, Kaladjian, A., additional, Dassa, D., additional, Corréard, N., additional, Dubois, E., additional, Micoulaud-Franchi, J.-A., additional, and Cermolacce, M., additional

Published
2013
Full Text
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40. Une approche historique des états mixtes

Author

Cermolacce, M., primary, Belzeaux, R., additional, Corréard, N., additional, Dassa, D., additional, Dubois, M., additional, Micoulaud-Franchi, J.-A., additional, Pringuey, D., additional, Fakra, E., additional, Maurel, M., additional, and Azorin, J.-M., additional

Published
2013
Full Text
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42. États mixtes. Évolution des classifications

Author

Pringuey, D., primary, Cherikh, F., additional, Giordana, B., additional, Fakra, E., additional, Dassa, D., additional, Cermolacce, M., additional, Belzeaux, R., additional, Maurel, M., additional, and Azorin, J.-M., additional

Published
2013
Full Text
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43. États mixtes et schizophrénie

Author

Fakra, E., primary, Belzeaux, R., additional, Pringuey, D., additional, Cermolacce, M., additional, Corréard, N., additional, Micoulaud-Franchi, J.-A., additional, and Azorin, J.-M., additional

Published
2013
Full Text
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50. Les endophénotypes tempéramentaux

Author

Azorin, J.-M., primary, Fakra, E., additional, Adida, M., additional, Belzeaux, R., additional, Cermolacce, M., additional, Mazzola, P., additional, Corréard, N., additional, Dubois, M., additional, Pringuey, D., additional, Sokolowsky, M., additional, and Kaladjian, A., additional

Published
2012
Full Text
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