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2. Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis

Author

Baumgartner, Maximilian, Lang, Michaela, Holley, Hunter, Crepaz, Daniel, Hausmann, Bela, Pjevac, Petra, Moser, Doris, Haller, Felix, Hof, Fabian, Beer, Andrea, Orgler, Elisabeth, Frick, Adrian, Khare, Vineeta, Evstatiev, Rayko, Strohmaier, Susanne, Primas, Christian, Dolak, Werner, Köcher, Thomas, Klavins, Kristaps, Rath, Timo, Neurath, Markus F., Berry, David, Makristathis, Athanasios, Muttenthaler, Markus, and Gasche, Christoph

Published
2021
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3. A Core Outcome Set for Inflammatory Bowel Diseases: Development and Recommendations for Implementation in Clinical Practice Through an International Multi-stakeholder Consensus Process.

Author

Fierens, Liselotte, Carney, Nicholas, Novacek, Gottfried, Woude, C Janneke van der, Siegmund, Britta, Casellas, Francesc, Borruel, Natalia, Huberts, Anouk S, Sonnenberg, Elena, Gerold, Nathalie, Primas, Christian, Hedin, Charlotte R H, Stamm, Tanja, Julsgaard, Mette, Fiorino, Gionata, Radice, Simona, Zini, Michela Luciana Luisa, Gross, Evelyn, Sander, Cornelia, and Arijs, Ingrid

Abstract

Background and Aims Standardising health outcome measurements supports delivery of care and enables data-driven learning systems and secondary data use for research. As part of the Health Outcomes Observatory [H2O] initiative, and building on existing knowledge, a core outcome set [COS] for inflammatory bowel diseases [IBD] was defined through an international modified Delphi method. Methods Stakeholders rated 90 variables on a 9-point importance scale twice, allowing score modification based on feedback displayed per stakeholder group. Two consecutive consensus meetings were held to discuss results and formulate recommendations for measurement in clinical practice. Variables scoring 7 or higher by ≥80% of the participants, or based on consensus meeting agreement, were included in the final set. Results In total, 136 stakeholders (45 IBD patients [advocates], 74 health care professionals/researchers, 13 industry representatives, and four regulators) from 20 different countries participated. The final set includes 18 case-mix variables, three biomarkers [haemoglobin to detect anaemia, C-reactive protein and faecal calprotectin to detect inflammation] for completeness, and 28 outcomes (including 16 patient-reported outcomes [PROs] and one patient-reported experience). The PRO-2 and IBD-Control questionnaires were recommended to collect disease-specific PROs at every contact with an IBD practitioner, and the Subjective Health Experience model questionnaire, PROMIS Global Health and Self-Efficacy short form, to collect generic PROs annually. Conclusions A COS for IBD, including a recommendation for use in clinical practice, was defined. Implementation of this set will start in Vienna, Berlin, Barcelona, Leuven, and Rotterdam, empowering patients to better manage their care. Additional centres will follow worldwide. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Inflammatory Bowel Disease and Risk of Major Bleeding During Anticoagulation for Venous Thromboembolism

Author

Scharrer, Susanna, Primas, Christian, Eichinger, Sabine, Tonko, Sebastian, Kutschera, Maximilian, Koch, Robert, Blesl, Andreas, Reinisch, Walter, Mayer, Andreas, Haas, Thomas, Feichtenschlager, Thomas, Fuchssteiner, Harry, Steiner, Pius, Ludwiczek, Othmar, Platzer, Reingard, Miehsler, Wolfgang, Tillinger, Wolfgang, Apostol, Sigrid, Schmid, Alfons, Schweiger, Karin, Vogelsang, Harald, Dejaco, Clemens, Herkner, Harald, and Novacek, Gottfried

Published
2021
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8. A Core Outcome Set for Inflammatory Bowel Diseases: Development and Recommendations for Implementation in Clinical Practice Through an International Multi-stakeholder Consensus Process

Author

Fierens, Liselotte, primary, Carney, Nicholas, additional, Novacek, Gottfried, additional, van der Woude, C Janneke, additional, Siegmund, Britta, additional, Casellas, Francesc, additional, Borruel, Natalia, additional, Huberts, Anouk S, additional, Sonnenberg, Elena, additional, Gerold, Nathalie, additional, Primas, Christian, additional, Hedin, Charlotte R H, additional, Stamm, Tanja, additional, Julsgaard, Mette, additional, Fiorino, Gionata, additional, Radice, Simona, additional, Zini, Michela Luciana Luisa, additional, Gross, Evelyn, additional, Sander, Cornelia, additional, Arijs, Ingrid, additional, Vakouftsi, Vasiliki-Rafaela, additional, Koltai, Tunde, additional, Charlafti, Iliàs, additional, and Ferrante, Marc, additional

Published
2023
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10. Factors Associated with Response to Systemic Corticosteroids in Active Ulcerative Colitis: Results from a Prospective, Multicenter Trial

Author

Blesl, Andreas, primary, Borenich, Andrea, additional, Gröchenig, Hans Peter, additional, Novacek, Gottfried, additional, Primas, Christian, additional, Reinisch, Walter, additional, Kutschera, Maximilian, additional, Illiasch, Constanze, additional, Hennlich, Barbara, additional, Steiner, Pius, additional, Koch, Robert, additional, Tillinger, Wolfgang, additional, Haas, Thomas, additional, Reicht, Gerhard, additional, Mayer, Andreas, additional, Ludwiczek, Othmar, additional, Miehsler, Wolfgang, additional, Steidl, Karin, additional, Binder, Lukas, additional, Baumann-Durchschein, Franziska, additional, Fürst, Stefan, additional, Reider, Simon, additional, Watschinger, Christina, additional, Wenzl, Heimo, additional, Moschen, Alexander, additional, Berghold, Andrea, additional, and Högenauer, Christoph, additional

Published
2023
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11. Prediction of Response to Systemic Corticosteroids in Active UC by Microbial Composition—A Prospective Multicenter Study

Author

Blesl, Andreas, primary, Wurm, Philipp, additional, Waschina, Silvio, additional, Gröchenig, Hans Peter, additional, Novacek, Gottfried, additional, Primas, Christian, additional, Reinisch, Walter, additional, Kutschera, Maximilian, additional, Illiasch, Constanze, additional, Hennlich, Barbara, additional, Steiner, Pius, additional, Koch, Robert, additional, Tillinger, Wolfgang, additional, Haas, Thomas, additional, Reicht, Gerhard, additional, Mayer, Andreas, additional, Ludwiczek, Othmar, additional, Miehsler, Wolfgang, additional, Steidl, Karin, additional, Binder, Lukas, additional, Reider, Simon, additional, Watschinger, Christina, additional, Fürst, Stefan, additional, Kump, Patrizia, additional, Moschen, Alexander, additional, Aden, Konrad, additional, Gorkiewicz, Gregor, additional, and Högenauer, Christoph, additional

Published
2023
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12. Prediction of Response to Systemic Corticosteroids in Active UC by Microbial Composition—A Prospective Multicenter Study.

Author

Blesl, Andreas, Wurm, Philipp, Waschina, Silvio, Gröchenig, Hans Peter, Novacek, Gottfried, Primas, Christian, Reinisch, Walter, Kutschera, Maximilian, Illiasch, Constanze, Hennlich, Barbara, Steiner, Pius, Koch, Robert, Tillinger, Wolfgang, Haas, Thomas, Reicht, Gerhard, Mayer, Andreas, Ludwiczek, Othmar, Miehsler, Wolfgang, Steidl, Karin, and Binder, Lukas

Published
2024
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21. Hypophosphataemia following ferric derisomaltose and ferric carboxymaltose in patients with iron deficiency anaemia due to inflammatory bowel disease (PHOSPHARE-IBD): a randomised clinical trial.

Author

Zoller, Heinz, Wolf, Myles, Blumenstein, Irina, Primas, Christian, Lindgren, Stefan, Thomsen, Lars L., Reinisch, Walter, and Iqbal, Tariq

Subjects
IRON deficiency anemia, INFLAMMATORY bowel diseases, HYPOPHOSPHATEMIA, CLINICAL trials, CANCER fatigue, COVID-19 pandemic, CROHN'S disease
Published
2023
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28. sj-pdf-1-ueg-10.1177_2050640620946874 - Supplemental material for Use of complementary and alternative medicine and low quality of life associate with the need for psychological and psychotherapeutic interventions in inflammatory bowel disease

Author

Kutschera, Maximilian, Waldhör, Thomas, Gröchenig, Hans Peter, Haas, Thomas, Wenzl, Heimo, Steiner, Pius, Koch, Robert, Feichtenschlager, Thomas, Eckhardt, Gerald, Mayer, Andreas, Kirchgatterer, Andreas, Ludwiczek, Othmar, Platzer, Reingard, Papay, Pavol, Gartner, Johanna, Fuchssteiner, Harry, Paul-Gerhard Peters, Reicht, Gerhard, Moser, Gabriele, Dejaco, Clemens, Vogelsang, Harald, Primas, Christian, Novacek, Gottfried, and Miehsler, Wolfgang

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 110308 Geriatrics and Gerontology, 69999 Biological Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-ueg-10.1177_2050640620946874 for Use of complementary and alternative medicine and low quality of life associate with the need for psychological and psychotherapeutic interventions in inflammatory bowel disease by Maximilian Kutschera, Thomas Waldhör, Hans Peter Gröchenig, Thomas Haas, Heimo Wenzl, Pius Steiner, Robert Koch, Thomas Feichtenschlager, Gerald Eckhardt, Andreas Mayer, Andreas Kirchgatterer, Othmar Ludwiczek, Reingard Platzer, Pavol Papay, Johanna Gartner, Harry Fuchssteiner, Paul-Gerhard Peters, Gerhard Reicht, Gabriele Moser, Clemens Dejaco, Harald Vogelsang, Christian Primas, Gottfried Novacek and Wolfgang Miehsler in United European Gastroenterology Journal

Published
2020
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29. Thumb sucking or nail biting in childhood and adolescence is associated with an increased risk of Crohn's disease: results from a large case-control study

Author

Teich, Niels, Mohl, Wolfgang, Primas, Christian, Novacek, Gottfried, Gauss, Annika, Walldorf, Jens, Felten, Gisela, Atreya, Raja, Kruis, Wolfgang, Bettenworth, Dominik, Roznowski, Artur Bartosz, Langhorst, Jost, Schmidt, Karen, Bruns, Tony, Stallmach, Andreas, Teich, Niels, Mohl, Wolfgang, Primas, Christian, Novacek, Gottfried, Gauss, Annika, Walldorf, Jens, Felten, Gisela, Atreya, Raja, Kruis, Wolfgang, Bettenworth, Dominik, Roznowski, Artur Bartosz, Langhorst, Jost, Schmidt, Karen, Bruns, Tony, and Stallmach, Andreas

Abstract

Background The hygiene hypothesis suggests that a reduction in microbial exposure contributes to an impaired immune response later in life and increases the incidence of immune-mediated diseases such as inflammatory bowel diseases (IBD). Thumb sucking and nail biting are two early habits that modulate the oral microbiota composition and antigen load. Objective We hypothesized a lower risk of Crohn's disease (CD) and ulcerative colitis (UC) in adults with prior thumb sucking and nail biting. Methods 918 IBD cases and their 918 siblings without IBD were asked to fill out a survey containing 32 questions on environmental factors in childhood and early adulthood. Prevalence of thumb sucking and/or nail biting at the usually well-remembered time of (1) school enrollment and (2) coming-of-age ceremonies was the predefined combined risk factor of this study. Results 65% of the patients were female and 57% suffered from CD. About 49% of IBD patients but only 44% of their siblings reported thumb sucking/nail biting at the time of school enrollment or coming-of-age (p = .007). Sensitivity analysis revealed that this difference was observed in patients with CD (50% versus 41%; RR= 1.22; 95% CI 1.09-1.37,p = .001) but not in patients with UC (49% versus 48%; RR= 1.02; 95% CI 0.90-1.17;p = .83). Conclusion Contrary to our expectation and challenging the hygiene hypothesis, we found that common oral habits are not protective against IBD. Instead, nail biting at the time of school enrollment and coming-of-age was a statistically significant risk factor for CD in our cohort. Key summary Evidence available before this study:The hygiene hypothesis suggests that a reduction in microbial exposure due to improved health activities has contributed to an immunological imbalance in the intestine and an increased incidence of allergic and autoimmune diseases. A population-based birth cohort study has demonstrated that thumb-sucking and nail biting in children lead to a reduction of the risk

Published
2020

31. 443 – Intestinal Biofilms are an Endoscopic Feature of Irritable Bowel Syndrome

Author

Baumgartner, Maximilian, primary, Lang, Michaela, additional, Orgler, Elisabeth, additional, Khare, Vineeta, additional, Moser, Doris, additional, Holley, Hunter, additional, Gmainer, Christina, additional, Krnjic, Anita, additional, Evstatiev, Rayko, additional, Primas, Christian, additional, Mandorfer, Mattias, additional, Kazemi-Shirazi, Lili, additional, Zioutis, Christos, additional, Berry, David, additional, and Gasche, Christoph, additional

Published
2019
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34. Use of complementary and alternative medicine and low quality of life associate with the need for psychological and psychotherapeutic interventions in inflammatory bowel disease

Author

Kutschera, Maximilian, Waldhör, Thomas, Gröchenig, Hans Peter, Haas, Thomas, Wenzl, Heimo, Steiner, Pius, Koch, Robert, Feichtenschlager, Thomas, Eckhardt, Gerald, Mayer, Andreas, Kirchgatterer, Andreas, Ludwiczek, Othmar, Platzer, Reingard, Papay, Pavol, Gartner, Johanna, Fuchssteiner, Harry, Peters, Paul‐Gerhard, Reicht, Gerhard, Moser, Gabriele, Dejaco, Clemens, Vogelsang, Harald, Primas, Christian, Novacek, Gottfried, and Miehsler, Wolfgang

Abstract

Patients with inflammatory bowel disease (IBD) suffer from various symptoms, impairing their quality of life and often affecting psychosocial issues. This may lead to the need for additional psychological care. This study investigated patients' subjective need for integrated psychosomatic support and psychotherapy and indicators for it. This is a cross‐sectional multicentre study in Austrian IBD patients who were in routine care at 18 IBD outpatient clinics. Patients filled in an anonymous, validated questionnaire (Assessment of the Demand for Additional Psychological Treatment Questionnaire [ADAPT]) assessing the need for psychological care. The ADAPT gives two separate scores: the need for integrated psychosomatic support and for psychotherapy. In addition, health‐related quality of life and the use of complementary and alternative medicine as well as clinical and socio‐demographic variables were queried. Multivariable regression analysis was performed to estimate the effect of the previously mentioned variables on the need for additional psychological care. Of 1286 patients, 29.7% expressed a need for additional psychological care, 19.6% expressed a need for integrated psychosomatic support and 20.2% expressed a need for psychotherapy. In the multivariable analysis, the two strongest indicators for the need for both types of psychological care were the use of complementary and alternative medicine (for integrated psychosomatic support: odds ratio = 1.64, 95% confidence interval 1.13–2.39, p= 0.010; for psychotherapy: odds ratio = 1.74, 95% confidence interval 1.20–2.53, p= 0.004), and a low health‐related quality of life score (for integrated psychosomatic support: odds ratio = 0.95, 95% confidence interval 0.94–0.96, p< 0.001; for psychotherapy: odds ratio = 0.96, 95% confidence interval 0.94–0.97, p< 0.001). About 30% of the Austrian IBD patients expressed a need for integrated psychosomatic support and/or psychotherapy. The most important indicators for this need were the use of complementary and alternative medicine and low quality of life. What is already known? Despite ongoing improvement of treatment options, patients may not respond to treatment or may develop side effects. Due to this burden of disease, patients may also suffer from psychological symptoms, such as depressionIn our previous study in 2008, we found that 31% of patients with inflammatory bowel disease (IBD) expressed a subjective need for psychological interventions Despite ongoing improvement of treatment options, patients may not respond to treatment or may develop side effects. Due to this burden of disease, patients may also suffer from psychological symptoms, such as depression In our previous study in 2008, we found that 31% of patients with inflammatory bowel disease (IBD) expressed a subjective need for psychological interventions What are the significant and/or new findings of the study? Despite improvements in therapy, around 30% of patients with IBD express a subjective need for psychological interventionsThis subjective need for psychological interventions is associated with complementary and alternative medicine use and low quality of life Despite improvements in therapy, around 30% of patients with IBD express a subjective need for psychological interventions This subjective need for psychological interventions is associated with complementary and alternative medicine use and low quality of life

Published
2021
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36. Use of complementary and alternative medicine and low quality of life associate with the need for psychological and psychotherapeutic interventions in inflammatory bowel disease

Author

Kutschera, Maximilian, Waldhör, Thomas, Gröchenig, Hans Peter, Haas, Thomas, Wenzl, Heimo, Steiner, Pius, Koch, Robert, Feichtenschlager, Thomas, Eckhardt, Gerald, Mayer, Andreas, Kirchgatterer, Andreas, Ludwiczek, Othmar, Platzer, Reingard, Papay, Pavol, Gartner, Johanna, Fuchssteiner, Harry, Peters, Paul-Gerhard, Reicht, Gerhard, Moser, Gabriele, Dejaco, Clemens, Vogelsang, Harald, Primas, Christian, Novacek, Gottfried, and Miehsler, Wolfgang

Abstract

Introduction Patients with inflammatory bowel disease suffer from various symptoms, impairing their quality of life and often affecting psychosocial issues. This may lead to the need for additional psychological care. This study investigated patients’ subjective need for integrated psychosomatic support and psychotherapy and indicators for it.Materials and methods This is a cross-sectional multicentre study in Austrian inflammatory bowel disease patients who were in routine care at 18 inflammatory bowel disease outpatient clinics. Patients filled in an anonymous, validated questionnaire (Assessment of the Demand for Additional Psychological Treatment Questionnaire, ADAPT) assessing the need for psychological care. The Assessment of the Demand for Additional Psychological Treatment Questionnaire gives two separate scores: the need for integrated psychosomatic support and for psychotherapy. In addition, health-related quality of life and the use of complementary and alternative medicine as well as clinical and sociodemographic variables were queried. Multivariable regression analysis was performed to estimate the effect of the previously mentioned variables on the need for additional psychological care.Results Of 1286 patients, 29.7% expressed a need for additional psychological care, 19.6% expressed a need for integrated psychosomatic support and 20.2% expressed a need for psychotherapy. In the multivariable analysis, the two strongest indicators for the need for both types of psychological care were the use of complementary and alternative medicine (for integrated psychosomatic support: odds ratio?=?1.64, 95% confidence interval 1.13–2.39, p?=?0.010; for psychotherapy: odds ratio?=?1.74, 95% confidence interval 1.20–2.53, p?=?0.004), and a low health-related quality of life score (for integrated psychosomatic support: odds ratio?=?0.95, 95% confidence interval 0.94–0.96, p?

Published
2024
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42. Mo1256 Role of Fecal Calprotection in Predicting Ileocolonic Endoscopic Recurrence in Postoperative Crohn's Disease

Author

Primas, Christian, primary, Frühwald, Gertrud, additional, Angelberger, Sieglinde, additional, Allerstorfer, David, additional, Papay, Pavol, additional, Eser, Alexander, additional, Gratzer, Cornelia, additional, Dejaco, Clemens, additional, Reinisch, Walter, additional, Novacek, Gottfried, additional, and Vogelsang, Harald, additional

Published
2013
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43. Anogenital Human Papillomavirus Prevalence is Unaffected by Therapeutic Tumour Necrosis Factor-alpha Inhibition.

Author

HANDISURYA, Alessandra, LÁZÁR, Stefanie, PAPAY, Pavol, PRIMAS, Christian, HAITEL, Andrea, HORVAT, Reinhard, TANEW, Adrian, VOGELSANG, Harald, and KIRNBAUER, Reinhard

Subjects
TUMOR necrosis factors, PAPILLOMAVIRUS diseases, DISEASE prevalence, INFLAMMATORY bowel diseases, PHOTOTHERAPY, SEROPREVALENCE, THERAPEUTICS
Abstract

Patients receiving tumour necrosis factor alpha (TNF-α) inhibitors are at increased risk of exacerbation of (myco-)bacterial and some viral infections. However, information on anogenital human papillomavirus (HPV) infection in these patients is sparse or conflicting. In this study 222 patients with psoriasis or inflammatory bowel disease (IBD), who received either anti-TNF-α inhibitors or alternatives (purine-, folic acid analogues, phototherapy, fumaric ester, mesalazine) continuously for at least 6 months, were evaluated for the presence of anogenital HPV-induced lesions, mucosal HPV DNA, and serological status of mucosal low-risk HPV6 and high-risk HPV16/HPV18. Hallmarks of anogenital HPV infection were more frequently detected in patients with psoriasis than in those with IBD. HPV-induced lesions, viral DNA, and seroprevalence were not elevated in participants with psoriasis or IBD, who received TNF-α inhibitors for a mean duration of 31.4 months (range 6-96 months) compared with recipients of alternative or no treatment. TNF-α blockade for a mean period of 31.4 months does not increase detectable anogenital HPV infection or disease. [ABSTRACT FROM AUTHOR]

Published
2016
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48. Granulocyte Activation as Measured by CD64 Expression on Pmns Reflects Inflammatory Activity in Inflammatory Bowel Disease

Author

Eser, Alexander, primary, Primas, Christian, additional, Papay, Pavol, additional, Brehovsky, Sonja, additional, Lichtenberger, Cornelia, additional, Mikulits, Andrea, additional, Angelberger, Sieglinde, additional, Novacek, Gottfried, additional, Vogelsang, Harald, additional, Tillinger, Wolfgang, additional, and Reinisch, Walter, additional

Published
2011
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49. Factors impacting the results of interferon-γ release assay and tuberculin skin test in routine screening for latent tuberculosis in patients with inflammatory bowel diseases

Author

Papay, Pavol, primary, Eser, Alexander, additional, Winkler, Stefan, additional, Frantal, Sophie, additional, Primas, Christian, additional, Miehsler, Wolfgang, additional, Novacek, Gottfried, additional, Vogelsang, Harald, additional, Dejaco, Clemens, additional, and Reinisch, Walter, additional

Published
2011
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