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Your search keyword '"Prilipov, Alexey G."' showing total 11 results
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11 results on '"Prilipov, Alexey G."'

2. The adaptive potential of North American subtype H7N2 avian influenza viruses to mammals

Author

Lyashko, Aleksandr V., primary, Rudneva, Irina A., additional, Shcherbinin, Dmitrii N., additional, Lomakina, Natalia F., additional, Treshchalina, Anastasia A., additional, Kupriyanova, Irina M., additional, Gambaryan, Alexandra S., additional, Timofeeva, Elena B., additional, Shilov, Aleksandr A., additional, Sadykova, Galina K., additional, Prilipov, Alexey G., additional, Timofeev, Boris I., additional, Shmarov, Maxim M., additional, Ryazanova, Elena L., additional, and Timofeeva, Tatiana A., additional

Published
2024
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3. Antigenic Architecture of the H7N2 Influenza Virus Hemagglutinin Belonging to the North American Lineage

Author

Lyashko, Aleksandr V., primary, Timofeeva, Tatiana A., additional, Rudneva, Irina A., additional, Lomakina, Natalia F., additional, Treshchalina, Anastasia A., additional, Gambaryan, Alexandra S., additional, Sorokin, Evgenii V., additional, Tsareva, Tatiana R., additional, Adams, Simone E., additional, Prilipov, Alexey G., additional, Sadykova, Galina K., additional, Timofeev, Boris I., additional, Logunov, Denis Y., additional, and Gintsburg, Alexander L., additional

Published
2023
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4. Antigenic Architecture of the H7N2 Influenza Virus Hemagglutinin Belonging to the North American Lineage.

Author

Lyashko, Aleksandr V., Timofeeva, Tatiana A., Rudneva, Irina A., Lomakina, Natalia F., Treshchalina, Anastasia A., Gambaryan, Alexandra S., Sorokin, Evgenii V., Tsareva, Tatiana R., Adams, Simone E., Prilipov, Alexey G., Sadykova, Galina K., Timofeev, Boris I., Logunov, Denis Y., and Gintsburg, Alexander L.

Subjects
AVIAN influenza, INFLUENZA viruses, AVIAN influenza A virus, HEMAGGLUTININ, MONOCLONAL antibodies, AMINO acids
Abstract

The North American low pathogenic H7N2 avian influenza A viruses, which lack the 220-loop in the hemagglutinin (HA), possess dual receptor specificity for avian- and human-like receptors. The purpose of this work was to determine which amino acid substitutions in HA affect viral antigenic and phenotypic properties that may be important for virus evolution. By obtaining escape mutants under the immune pressure of treatment with monoclonal antibodies, antigenically important amino acids were determined to be at positions 125, 135, 157, 160, 198, 200, and 275 (H3 numbering). These positions, except 125 and 275, surround the receptor binding site. The substitutions A135S and A135T led to the appearance of an N-glycosylation site at 133N, which reduced affinity for the avian-like receptor analog and weakened binding with tested monoclonal antibodies. Additionally, the A135S substitution is associated with the adaptation of avian viruses to mammals (cat, human, or mouse). The mutation A160V decreased virulence in mice and increased affinity for the human-type receptor analog. Conversely, substitution G198E, in combination with 157N or 160E, displayed reduced affinity for the human-type receptor analog. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination

Author

Astakhova, Ekaterina A., primary, Byazrova, Maria G., additional, Yusubalieva, Gaukhar M., additional, Kulemzin, Sergey V., additional, Kruglova, Natalia A., additional, Prilipov, Alexey G., additional, Baklaushev, Vladimir P., additional, Gorchakov, Andrey A., additional, Taranin, Alexander V., additional, and Filatov, Alexander V., additional

Published
2022
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