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19 results on '"Prigozhina TA"'

1. Mechanism of action of breakdown products of granulocytes on granulocytopoiesis

Author

Prigozhina Ta, Kurbanova Gn, and Kakhetelidze Mg

Subjects
medicine.medical_specialty, Spleen, General Medicine, Granulocyte, Biology, Body weight, General Biochemistry, Genetics and Molecular Biology, Haematopoiesis, Blood serum, medicine.anatomical_structure, Endocrinology, Mechanism of action, Internal medicine, medicine, Homologous chromosome, Stem cell, medicine.symptom
Abstract

The leukopoietic activity of blood serum was studied after injection of the breakdown products of 12 and 60 million homologous granulocytes per 100 g body weight into intact Wistar rats, and the character of the action of the serum on proliferation and differentiation of hematopoietic stem cells was determined in the spleen of lethally irradiated mice. The accumulation of granulopoietins in the blood under the influence of the granulocyte breakdown products was greater after injection of material from 12 million granulocytes. Granulocytopoietins stimulate the proliferative activity of stem cells and their differentiation into granulocytes in the spleen of lethally irradiated mice. It is concluded that granulocytes breakdown products have a stimulating action on hematopoiesis through granulocytopoietins.

Published
1978

2. Effect of the various fractions of leukocytic pyrogen on hematopoiesis

Author

Prigozhina Ta, Rybakina Eg, El'kina Oa, Sorokin Av, Kurbanova Gn, and Kakhetelidze Mg

Subjects
Haematopoiesis, Chromatography, Biochemistry, Chemistry, Sephadex, chemical and pharmacologic phenomena, hemic and immune systems, General Medicine, Fractionation, Inhibitory postsynaptic potential, General Biochemistry, Genetics and Molecular Biology
Abstract

Fractionation of leukocytic pyrogen on a column of Sephadex G-75 yielded two separate fractions, one stimulating hematopoiesis, the other possessing pyrogenic activity but inhibiting hematopoiesis. The elution profile of the Sephadex G-75 column suggests that the stimulating action is a property of high-molecular-weight substances whereas the pyrogenic and inhibitory actions are properties of low-molecular-weight substances. Pyrogenic and inhibitory activities are perhaps connected with different substances. The nature of the inhibitory factor requires further study. It presumably is a substance of chalone type.

Published
1978

3. Hematopoietic action of high-molecular-weight fractions of leukocytic pyrogen

Author

Rybakina Eg, Prigozhina Ta, Kurbanova Gn, El'kina Oa, Kakhetelidze Mg, and Sorokin Av

Subjects
medicine.medical_specialty, Absolute number, Spleen, Stimulation, General Medicine, Fractionation, Granulocyte, Biology, General Biochemistry, Genetics and Molecular Biology, Peripheral blood, Haematopoiesis, medicine.anatomical_structure, Endocrinology, Internal medicine, Immunology, medicine, Bone marrow
Abstract

By fractionation of rabbit leukocytic pyrogen (LP) on a Sephadex column and by the alcohol method a nonpyrogenic protein fraction of LP was isolated. In intact rats this fraction caused stimulation of granulocytopoiesis, an increase in the proliferative activity of the granulocytes and their absolute number in bone marrow and peripheral blood, and also an increase in the number of macrocolonies in the spleen of lethally irradiated mice on account of an increase in the number of granulocyte colonies.

Published
1980

4. [Effectiveness of plasmapheresis on the PF-0.5 blood separator in patients with paraproteinemic hemoblastoses].

Author

Abdullaev OM, Postnikov AA, Prigozhina TA, Likhovetskaia ZM, and Mokeeva RA

Subjects
Adult, Aged, Blood Viscosity, Chronic Disease, Combined Modality Therapy, Dextrans therapeutic use, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Multiple Myeloma blood, Multiple Myeloma therapy, Paraproteinemias blood, Plasmapheresis methods, Waldenstrom Macroglobulinemia blood, Waldenstrom Macroglobulinemia therapy, Paraproteinemias therapy, Plasmapheresis instrumentation
Abstract

Plasmapheresis on a Soviet-made PF-0.5 blood cell separator was performed in 20 PPH patients (altogether 33 sessions of plasmapheresis). 1600 to 3300 ml of plasma were removed during one session. Rheopolyglucin was mainly used as plasma-substituting liquid. The procedure was well tolerated by all the patients. After plasmapheresis biochemical indices were within normal. In multiple myeloma paraprotein was decreased by 42%. Waldenström's macroglobulinemia by 47%. Plasma viscosity was decreased 1.2- and 2-fold, respectively. The investigations showed a high efficacy and reliability of plasmapheresis with the help of the Soviet-made PF-0.5.

Published
1987

5. [Hemopoietic action of a rabbit leukocyte pyrogen].

Author

Fedorov NA, Veselkin PN, Kakhetelidze MG, Prigozhina TA, and Kurbanova GN

Subjects
Animals, Bone Marrow drug effects, Male, Molecular Weight, Rabbits, Rats, Rats, Inbred Strains, Time Factors, Hematopoiesis drug effects, Interleukin-1, Leukocytes physiology, Proteins pharmacology, Pyrogens pharmacology
Published
1982

7. [Effect of the serum of rats with the posterior hypothalamus nuclei destroyed on the formation of hemopoietic colonies in the spleen of fatally irradiated mice undergoing bone marrow cell transplantation].

Author

Fedorov NA, Likhovetskaia ZM, Kurbanova GN, Prigozhina TA, and L'vovich AI

Subjects
Animals, Colony-Forming Units Assay, Male, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Rats, Rats, Inbred Strains, Time Factors, Bone Marrow Transplantation, Hematopoiesis, Hypothalamus physiology, Hypothalamus, Posterior physiology, Immune Sera pharmacology, Spleen radiation effects
Published
1982

8. [Effect of leukocytic pyrogen on the leukopoiesis in intact rats].

Author

Prigozhina TA, Kakhetelidze MG, and Efremov OM

Subjects
Animals, Dose-Response Relationship, Drug, Leukocyte Count, Pyrogens administration & dosage, Rabbits, Rats, Granulocytes cytology, Hematopoiesis drug effects, Leukocytes cytology, Pyrogens pharmacology
Published
1976

9. [Action of granulocyte breakdown products on granulocytopoiesis].

Author

Kakhetelidze MG, Fedorov NA, Kurbanova GN, and Prigozhina TA

Subjects
Animals, Bone Marrow physiology, DNA biosynthesis, Male, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Rats, Stimulation, Chemical, Time Factors, Granulocytes metabolism, Hematopoiesis drug effects
Published
1980

10. [Hemorheologic disorders in shock of diverse etiology].

Author

Likhovetskaia ZM, Prigozhina TA, and Gorbunova NA

Subjects
Animals, Blood Flow Velocity, Blood Viscosity, Burns complications, Erythrocyte Aggregation, Erythrocyte Deformability, Male, Rats, Rats, Inbred Strains, Shock physiopathology, Shock, Hemorrhagic blood, Shock, Hemorrhagic physiopathology, Shock, Traumatic blood, Shock, Traumatic etiology, Shock, Traumatic physiopathology, Rheology, Shock blood
Abstract

Comparative investigation of rats has been conducted to study rheologic blood properties during relative compensation and decompensation of the hemorrhagic, traumatic and burning shock. The most obvious hemorheologic disturbances have been revealed during a burning shock and feebly marked-during a hemorrhagic shock.

Published
1988

11. [Action of the hypothalamus on hemopoiesis].

Author

Likhovetskaia ZM, Prigozhina TA, Kurbanova GN, L'vovich AI, and Kazakova PB

Subjects
Animals, Erythropoiesis, Granulocytes, Leukocytes, Mammillary Bodies physiology, Rats, Hematopoiesis, Hypothalamus physiology
Published
1984

12. [Hemopoietic action of the high-molecular fraction of leukocytic pyrogen].

Author

Prigozhina TA, Kurbanova GN, Kakhetelidze MG, Sorokin AV, and Rybakina EG

Subjects
Animals, Bone Marrow drug effects, Colony-Forming Units Assay, DNA biosynthesis, Leukocyte Count, Mice, Molecular Weight, Rabbits, Rats, Spleen drug effects, Hematopoiesis drug effects, Leukocytes analysis, Pyrogens pharmacology
Abstract

During fractionation of the rabbit leukocytic pyrogen (LP) on Sephadex column and by the ethanol method, the apyrogenic protein fraction was isolated. In intact rats this fraction induced granulocytopoiesis stimulation: a rise in granulocyte proliferative activity, an increase in total granulocyte count in the bone marrow and peripheral blood, and also a rise in the number of macrocolonies in the spleen of lethally irradiated mice due to an increase in granulocyte colonies.

Published
1980

14. [Effect of different leukocyte pyrogen fractions on hemopoiesis].

Author

Sorokin AV, Kurbanova GN, Prigozhina TA, Rybakina EG, and El'kina OA

Subjects
Animals, Bone Marrow drug effects, DNA metabolism, Dose-Response Relationship, Drug, Molecular Weight, Pyrogens isolation & purification, Rabbits, Rats, Hematopoiesis drug effects, Leukocytes, Pyrogens pharmacology
Abstract

Fractionation of leukocyte pyrogen on a column of Sephadex G-75 made it possible to obtain separately the fraction stimulating the hemopoiesis and the fraction possessing the pyrogenic activity and inhibiting the hemopoiesis. Judging by the elution profile of Sephadex column G-75, substances of high molecular weight produced a stimulating action, and of low molecular weight--pyrogenic and inhibitory action. Possibly pyrogenic and inhibitory activities are connected with different substances. The nature of the inhibitory factor requires further investigation. It may be supposed that it is a substance of chalone type.

Published
1978

15. [Effect of the leukocytic pyrogen on the granulocytopoiesis of rats].

Author

Fedorov NA, Veselkin PN, Kakhetelidze MG, Prigozhina TA, and Sorokin AV

Subjects
Animals, Bone Marrow Cells, Dose-Response Relationship, Drug, Male, Rabbits, Rats, Granulocytes cytology, Hematopoiesis, Leukocytes cytology, Pyrogens administration & dosage, Pyrogens pharmacology
Published
1977

16. [Mechanism of action of leukocyte pyrogen on granulocytopoiesis].

Author

Prigozhina TA, Kurbanova GN, Kakhetelidze MG, and Sorokin AV

Subjects
Animals, Hybridization, Genetic, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Pyrogens isolation & purification, Rats, Stimulation, Chemical, Hematopoiesis drug effects, Leukocytes analysis, Pyrogens pharmacology
Published
1976

17. [Blood rheologic disorders in patients with polycythemia vera and their correction by therapeutic erythrocytapheresis].

Author

Likhovetskaia ZM, Prigozhina TA, Gorbunova NA, Kalinin NN, and Petrov MM

Subjects
Blood Coagulation Disorders blood, Blood Coagulation Disorders therapy, Blood Viscosity, Erythrocyte Aggregation, Erythrocyte Deformability, Humans, Polycythemia Vera blood, Polycythemia Vera therapy, Blood Coagulation Disorders etiology, Blood Component Removal methods, Erythrocyte Transfusion, Polycythemia Vera complications
Abstract

The rheologic blood properties were studied in patients with polycythemia vera (PV) before and after erythrocytapheresis. The patients with PV showed a complex of hemorheologic disorders (high blood viscosity at different rates of deviation, intensified red blood cell aggregation, decreased deformability of these cells) found to be implicated in the disease pathogenesis. Erythrocytapheresis promoted the improvement of the rheologic characteristics such as dynamic blood viscosity and the red blood cell aggregation ratio.

Published
1989

18. [Mechanism of action of granulocyte breakdown products on granulocytopoiesis].

Author

Kurbanova GN, Kakhemelidze MG, and Prigozhina TA

Subjects
Animals, Hybridization, Genetic, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Rats, Stimulation, Chemical, Cell Extracts pharmacology, Granulocytes analysis, Hematopoiesis, Leukocytes, Tissue Extracts pharmacology
Abstract

Blood serum leukopoietic activity after the injection to intact Wistar rats of products of 12 and 60 million homologous granulocytes lysis per 100 g of animal body weight, and the character of the serum action on the proliferation and differentiation of stem hematopoietic cells in the spleen of lethally irradiated mice were studied. Accumulation in the blood of granulocytopoietins resulting from the action of the products of granulocytes lysis was noted. Granulocytopoietins stimulated the proliferating activity of stem cells and their differentiation into granulocytes in the spleen of the lethally irradiated mice. A conclusion was drawn on the stimulating action of granulocyte lysis products on the hemopoiesis through the granulocytopoietins.

Published
1978

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