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2. Association between Perinatal Outcomes and Maternal Risk Factors: Age, Body Mass Index and Cigarette Smoking

Author

Martin-Alonso, Raquel, primary, Prieto, Paula, additional, Buhigas, Irene Fernandez, additional, German-Fernandez, Cristina, additional, Aramburu, Cristina, additional, Piqueras, Victor, additional, Cuenca-Gomez, Diana, additional, Ferrer, Emilia, additional, Rolle, Valeria, additional, Santacruz, Belen, additional, and Gil, María M., additional

Published
2024
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3. Factors related to mortality in a patient with chronic obstructive pulmonary disease in the Colombian population

Author

Tuta-Quintero, Eduardo, Bastidas-Goyes, Alirio, Giraldo-Cadavid, Luis F., Echeverri, Juliana, Botero, Juan D., Villarreal, Valentina, Zambrano, Camila, Rabe, Valeria, Hernández, Juan, Tavera, Daniel, Acosta, Juan, Martínez, Ángela, Granados, Carlos, Nieto, Maria, Román, Sergio E., Achry , William A., Guezguan-Pérez, Jonathan, Prieto, ´Paula, Parra-Cárdenas, Diana, Tuta-Quintero, Eduardo, Bastidas-Goyes, Alirio, Giraldo-Cadavid, Luis F., Echeverri, Juliana, Botero, Juan D., Villarreal, Valentina, Zambrano, Camila, Rabe, Valeria, Hernández, Juan, Tavera, Daniel, Acosta, Juan, Martínez, Ángela, Granados, Carlos, Nieto, Maria, Román, Sergio E., Achry , William A., Guezguan-Pérez, Jonathan, Prieto, ´Paula, and Parra-Cárdenas, Diana

Abstract

Introduction. Data in low- and middle-income countries on mortality and risk factors in patients with Chronic Obstructive Pulmonary Disease (COPD) are limited.Objective. To identify the incidence of death and its relationship with variables in a Colombian population during 12 months of follow-up.Materials and methods. Retrospective study in subjects diagnosed with COPD in a third level clinic in Colombia. Odds ratios (ORs) were calculated using multivariable logistic regression analysis with the outcome variable mortality at 12 months.Results. 524 patients were admitted, 18.1% (95/524) died, the average age was 69.7 (SD: 8.92) and 59.2% (310/524) were women. The variables associated with mortality were age (OR:6.54, 95% CI:3.65-11.36; p<0.001), years of exposure to wood smoke (OR:4.59, CI 95% CI:1.64-12.82, p=0.002), chronic heart failure (OR:1.81, 95% CI:1.13-2.91, p=0.014), cerebrovascular disease (OR: 3.35, 95% CI: 1.04-10.75; p=0.032) and chronic kidney disease (OR: 6.96, 95% CI: 1.15-41.67; p=0.015). When adjusting the variables in the multivariate analysis, only an association was found for sex (OR: 1.55, 95% CI; 0.95-2.54; p=0.008) and age (OR: 5.94, 95% CI 95%: 3.3-10.69, p<0.001).Conclusion. Age, years of exposure to wood smoke, chronic heart failure, cerebrovascular and chronic kidney disease were clinical variables associated with a fatal outcome. However, age and sex were the only variables related to mortality when adjusted for confounding factors., Introducción. Los datos en países de medianos y bajos ingresos sobre la mortalidad y factores de riesgo en pacientes con enfermedad pulmonar obstructiva crónica (EPOC) son limitados.Objetivo. Identificar la incidencia de muerte y su relación con variables en una población colombiana durante 12 meses de seguimiento.Material y métodos. Estudio retrospectivo en sujetos con diagnóstico de EPOC una clínica de tercer nivel en Colombia. Los cocientes de probabilidades (OR) se calcularon mediante un análisis de regresión logística multivariable con la variable de resultado mortalidad a los 12 meses.Resultados. Ingresaron 524 pacientes, el 18,1% (95/524) murieron, la edad promedio fue de 69,7 (DE:8,92) y el 59,2% (310/524) eran mujeres. Las variables asociadas a con la mortalidad fueron la edad (OR:6,54, IC del 95%:3,65-11,36; p<0,001), años de exposición al humo de leña (OR:4,59, IC del 95%:1,64-12,82; p=0,002), insuficiencia cardiaca crónica (OR:1,81, IC del 95%:1,13-2,91; p=0,014), enfermedad cerebrovascular (OR:3,35, IC del 95%:1,04-10,75; p=0,032) y enfermedad renal crónica (OR:6,96, IC del 95%:1,15-41,67; p=0,015). Al ajustar las variables en el análisis multivariado únicamente se mostró asociación en el sexo (OR:1,55, IC del 95%;0,95-2,54; p=0,008) y la edad (OR:5,94, IC del 95%:3,3-10,69; p<0,001).Conclusión. La edad, los años de exposición al humo de leña, la insuficiencia cardiaca crónica, la enfermedad cerebrovascular y renal crónica fueron variables clínicas asociadas a un desenlace fatal. Sin embargo, la edad y el sexo fueron las únicas variables relacionadas con la mortalidad al ser ajustadas por factores de confusión.

Published
2024

4. CD66b+/CD68+ circulating extracellular vesicles, lactate dehydrogenase and neutrophil‐to‐lymphocyte ratio can differentiate coronavirus disease 2019 severity during and after infection.

Author

Suades, Rosa, Greco, Maria Francesca, Prieto, Paula, Padró, Teresa, Devaux, Yvan, Domingo, Pere, and Badimon, Lina

Subjects
COVID-19, EXTRACELLULAR vesicles, NEUTROPHIL lymphocyte ratio, SARS-CoV-2, COVID-19 pandemic
Abstract

Coronavirus disease 2019 (COVID‐19) has been a major public health burden. We hypothesised that circulating extracellular vesicles (cEVs), key players in health and disease, could trace the cell changes during COVID‐19 infection and recovery. Therefore, we studied the temporal trend of cEV and inflammatory marker levels in plasma samples of COVID‐19 patients that were collected within 24 h of patient admission (baseline, n = 80) and after hospital discharge at day‐90 post‐admission (n = 59). Inflammatory markers were measured by standard biochemical methods. cEVs were quantitatively and phenotypically characterized by high‐sensitivity nano flow cytometry. In patients recovered from COVID‐19 lower levels of inflammatory markers were detected. cEVs from vascular (endothelial cells) and blood (platelets, distinct immune subsets) cells were significantly reduced at day‐90 compared to admission levels, a pattern also observed for cEVs from progenitor, perivascular and epithelial cells. The best discriminatory power for COVID‐19 severity was found for inflammatory markers lactate dehydrogenase and neutrophil‐to‐lymphocyte ratio and for granulocyte/macrophage‐released CD66b+/CD68+‐cEVs. Albeit inflammatory markers were good indicators of systemic inflammatory response and discriminators of COVID‐19 remission, they do not completely reveal cell stress and organ damage states. cEVs reaching baseline pre‐infection levels at 90 days post‐infection in recovered patients discriminate parental cells affected by disease. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Association between Perinatal Outcomes and Maternal Risk Factors: A Cohort Study.

Author

Martin-Alonso, Raquel, Prieto, Paula, Fernández-Buhigas, Irene, German-Fernandez, Cristina, Aramburu, Cristina, Piqueras, Victor, Cuenca-Gomez, Diana, Ferrer, Emilia, Rolle, Valeria, Santacruz, Belén, and Gil, María M.

Subjects
GESTATIONAL diabetes, PREGNANCY complications, MATERNAL age, COHORT analysis, PREMATURE labor, MOLAR pregnancy
Abstract

Background and Objectives: The aim of this study was to analyze the association between maternal risk factors, such as age, body mass index (BMI), and cigarette smoking, and perinatal outcomes. Materials and Methods: We conducted a retrospective analysis based on prospectively collected data at Hospital Universitario de Torrejón (Madrid, Spain) between September 2017 and December 2019. All pregnant women with singleton pregnancies and non-malformed live fetuses attending their routine ultrasound examination at 11+0 to 13+6 weeks' gestation were invited to participate. The association between preeclampsia, preterm birth, gestational diabetes mellitus (GDM), small-for-gestational-age (SGA) or fetal-growth-restricted (FGR) neonates, and type of delivery and maternal age, BMI, and cigarette smoking was studied. Logistic mixed models were used to analyze the data. Results: A total of 1921 patients were included in the analysis. Women who were ≥40 years old had a significantly higher risk of having GDM (odds ratio (OR) 1.61, 95% confidence interval (CI) 1.08 to 2.36) and SGA neonates (OR 1.54, 95% CI 1.00 to 2.37). Women with a BMI < 18 had an increased rate of giving birth to SGA and FGR neonates (OR 3.28, 95% CI 1.51 to 7.05, and OR 3.73, 95% CI 1.54 to 8.37, respectively), whereas women with a BMI ≥ 35 had a higher risk of GDM (OR 3.10, 95% CI 1.95 to 4.89). Smoking increased the risk of having SGA and FGR neonates (OR 1.83, 95% CI 1.36 to 2.46, and OR 1.91, 95% CI 1.29 to 2.78). Conclusions: Advanced maternal age, low or high BMI, and smoking status are significant risk factors for pregnancy complications. Both clinicians and society should concentrate their efforts on addressing these factors to enhance reproductive health. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Inflammation status after retinal detachment could be modulate by TP53 gene

Author

Galindo‐Cabello, Nadia, primary, Pérez‐Prieto, Paula, additional, Fernández‐Fernández, Julio, additional, López‐García, Antonio, additional, García‐Vázquez, Carmen, additional, Rodríguez‐Cabello, José, additional, Lapresa, Rebeca, additional, Almeida, Angeles, additional, Pastor‐Idoate, Salvador, additional, and Usategui‐Martin, Ricardo, additional

Published
2024
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8. Factores relacionados con la mortalidad en pacientes con enfermedad pulmonar obstructiva crónica en población colombiana.

Author

Tuta-Quintero, Eduardo, Bastidas, Alirio R., Giraldo-Cadavid, Luis F., Echeverri, Juliana, Botero, Juan D., Villarreal, Valentina, Zambrano, Camila, Rabe, Valeria, Hernández, Juan, Tavera, Daniel, Acosta, Juan, Martínez, Ángela, Granados, Carlos, Nieto, María, Román, Sergio E., Achury, William A., Guezguan-Pérez, Jonathan, Prieto, Paula, and Parra-Cárdenas, Diana

Subjects
CHRONIC obstructive pulmonary disease, LOGISTIC regression analysis, CHRONIC kidney failure, DISEASE risk factors, MIDDLE-income countries
Abstract

Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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9. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

Author

Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, Vallejo, Alejandro, Serrano-Villar, Sergio, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, de Zárraga, Miguel Alberto, and Vivancos, María J

Published
2020
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13. Intereses específicos de Colombia

Author

Zuluaga Castaño, Óscar, primary, Aristizábal Mustafá, Héctor Fabio, additional, Sánchez Pesca, Kerly, additional, Cabrera Izquierdo, Óscar, additional, Téllez Corredor, Juana, additional, Anne Lowe, Louise, additional, Flórez Cuervo, Raúl, additional, Hernández Ruiz, Adolfo Enrique, additional, Macías Tolosa, Héctor Andrés, additional, Álvarez Calderón, Carlos Enrique, additional, Alarcón Moreno, María Johanna, additional, Valdivieso Collazos, Andrés Mauricio, additional, García Briceño, Ricardo, additional, Correa Merchán, Sofía, additional, Vera Piñeros, Diego, additional, Prieto, Paula, additional, and Garzón, Daniela, additional

Published
2020
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15. A quasi-cohort trend analysis of adult obesity in Colombia.

Author

Castro-Prieto, Paula Andrea, Spijker, Jeroen, and Recaño, Joaquín

Subjects
*TREND analysis, *ETHNICITY, *OBESITY, *AGE differences, *OVERWEIGHT children, *BODY mass index
Abstract

In Colombia, the prevalence of obesity has been increasing in recent years due to changes in dietary and nutritional patterns. While previous studies have focussed on describing obesity and its associated factors, they have mainly used a cross-sectional methodology. Accordingly, this study aims to conduct a descriptive quasi-cohort analysis to capture age-specific cohort trends in body mass index (BMI) according to sex and ethnicity (indigenous, Afro-Colombian, and the remaining population). The study utilised data from the National Survey of the Nutritional Situation in Colombia (ENSIN) conducted in 2005, 2010, and 2015 that included 214,136 individuals aged 20–64 years after screening. Data on ethnicity were only available from the 2010 and 2015 surveys. Overall, the prevalence of obesity increased by 6.1 percentage points (from 15.2% to 21.3%) between 2005 and 2015 (men from 10.4% to 15.7%; women from 18.2% to 25.7%). Among Afro-Colombians, obesity rose 6.6 percentage points (from 19.4% to 26.0%), again more so in women than in men (2015: 35.2% versus 17.8%). Among indigenous people, the proportion increased by 5.3 percentage points (from 13.5% to 18.8%), with women reporting highest rates (2015: 23.7% against 12.6% in men). Age- and cohort-specific results also indicate that recent adult cohorts are experiencing sharp increases in BMI, for example, while 25–29-year-old males born in 1975–1979 had a BMI of 24.2 kg/m2, among 40–44-year-olds of the same cohort, this equalled 26.8 kg/m2. In the case of women, these age differences in BMI among the same cohort are even greater (24.4 and 28.0 kg/m2). In summary, the results of this study indicate that Colombia is still in the early stages of the obesity transition, urging the need to monitor obesity trends in Colombia from both an age and cohort perspective. To achieve this, longitudinal surveys or repeated cross-sectional surveys like the ENSIN could be utilised. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Switching to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat in heavily antiretroviral-experienced, virologically suppressed HIV-infected adults receiving complex regimens

Author

Podzamczer, Daniel, primary, Imaz, Arkaitz, additional, Lopez-Lirola, Ana, additional, Knobel, Hernando, additional, Masiá, Mar, additional, Fanciulli, Chiara, additional, Hernández, Cristina, additional, Lagarde, María, additional, Gutierrez, Angela, additional, Curran, Adrià, additional, Morano, Luis, additional, Montero-Alonso, Marta, additional, Troya, Jesús, additional, Rigo, Raúl, additional, Casadellà, María, additional, Navarro-Alcaraz, Antonio, additional, Ardila, Fernando, additional, Parera, Mariona, additional, Bernal, Enrique, additional, Echeverria, Patricia, additional, Estrada, Vicente, additional, Hidalgo-Tenorio, Carmen, additional, Macias, Juan, additional, Prieto, Paula, additional, Portilla, Joaquín, additional, Valencia, Eulalia, additional, Vivancos, María Jesús, additional, and Rivero, Antonio, additional

Published
2023
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20. Corrigendum to “O-GlcNAc transferase acts as a critical nutritional node for the control of liver homeostasis” [JHEP Reports 6 [2024] 100878]

Author

Ortega-Prieto, Paula, Parlati, Lucia, Benhamed, Fadila, Regnier, Marion, Cavalcante, Isadora, Montabord, Mélanie, Onifarasoaniaina, Rachel, Favier, Maryline, Pavlovic, Natasa, Magusto, Julie, Cauzac, Michèle, Pagesy, Patrick, Gautheron, Jérémie, Desdouets, Chantal, Guilmeau, Sandra, Issad, Tarik, and Postic, Catherine

Published
2024
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23. Switching to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat in heavily antiretroviral-experienced, virologically suppressed HIV-infected adults receiving complex regimens

Author

Gilead Sciences, Red Española de Investigación en SIDA, Fundació Lluita contra les Infeccions, Podzamczer, Daniel, Imaz, Arkaitz, López-Lirola, Ana, Knobel, Hernando, Masiá, Mar, Fanciulli, Chiara, Hernández, Cristina, Lagarde, María, Gutiérrez, Angela, Curran, Adrià, Morano, Luis, Montero-Alonso, Marta, Troya, Jesús, Rigo-Bonnin, Raúl, Casadellà, María, Navarro-Alcaraz, Antonio, Ardila, Fernando, Parera, Mariona, Bernal, Enrique, Echeverria, Patricia, Estrada, Vicente, Hidalgo-Tenorio, Carmen, Macías Sánchez, Juan, Prieto, Paula, Portilla, Joaquín, Valencia, Eulalia, Vivancos-Gallego, María Jesús, Rivero, Antonio, Gilead Sciences, Red Española de Investigación en SIDA, Fundació Lluita contra les Infeccions, Podzamczer, Daniel, Imaz, Arkaitz, López-Lirola, Ana, Knobel, Hernando, Masiá, Mar, Fanciulli, Chiara, Hernández, Cristina, Lagarde, María, Gutiérrez, Angela, Curran, Adrià, Morano, Luis, Montero-Alonso, Marta, Troya, Jesús, Rigo-Bonnin, Raúl, Casadellà, María, Navarro-Alcaraz, Antonio, Ardila, Fernando, Parera, Mariona, Bernal, Enrique, Echeverria, Patricia, Estrada, Vicente, Hidalgo-Tenorio, Carmen, Macías Sánchez, Juan, Prieto, Paula, Portilla, Joaquín, Valencia, Eulalia, Vivancos-Gallego, María Jesús, and Rivero, Antonio

Abstract

[Objectives] To evaluate the efficacy and safety of the two-pill regimen bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat as a switching strategy in heavily treatment-experienced people living with HIV (PLWH)., [Methods] Multicentre, prospective, single-arm pilot clinical trial. Participants were virologically suppressed adults receiving a stable antiretroviral regimen of at least three pills from at least three drug families due to previous virological failures and/or toxicities with no documented resistance to integrase strand transfer inhibitors or darunavir (≥15 points, Stanford). Clinical and laboratory assessments were performed at 0, 4, 12, 24, 36 and 48 weeks. HIV-1 proviral DNA was amplified and sequenced by Illumina at baseline. Plasma bictegravir concentrations were determined in 22 patients using UHPLC-MS/MS. The primary study endpoint was viral load (VL)< 50 copies/mL at Week 48 (ITT)., [Results] We enrolled 63 participants (92% men) with median baseline CD4 count of 515 cells/mm3 (IQR: 334.5–734.5), 24 years on ART (IQR: 15.9–27.8). The median number of pills was 4 (range: 3–10). At baseline, proviral DNA was amplified in 39 participants: 33/39 had resistance mutations. Three participants discontinued owing to toxicity. At 48 weeks, 95% had VL < 50 copies/mL by ITT and 100% by PP analysis. A modest increase was observed in the bictegravir plasma concentration, and a significant decrease in estimated glomerular filtration rate was observed only at Week 4, probably related to interaction with renal transporters., [Conclusions] Our data suggest that BIC/FTC/TAF + darunavir/cobicistat is an effective, well-tolerated regimen that may improve convenience and, potentially, long-term success in stable heavily pre-treated PLWH.

Published
2023

24. Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units.

Author

Moraga, Paloma, Prieto, Paula, Conradie, Almari, Benhayoun, Majda, Rousell, Vicki, Davy, Maria, Fuhr, Uwe, Antonijoan Arbos, Rosa, Abad‐Santos, Francisco, Portolés, Antonio, Van Duinen, Jolanda, Carcas, Antonio J., and Borobia, Alberto M.

Subjects
*CLINICAL trials, *PUBLIC-private sector cooperation, *ACADEMIA
Abstract

First‐time‐in‐human (FTIH) trials are designed to generate information on the safety, tolerability, as well as the pharmacokinetic and pharmacodynamics profile of new drugs. To ensure the safety of participants, these trials need to be conducted at specifically equipped phase I clinical trial units (CTUs). In accordance with the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Guideline for Good Clinical Practice (GCP) and the European Union (EU) regulatory guidelines, one of the aims of the European Regime Accelerator for Tuberculosis (ERA4TB) project is to collaboratively create a feasibility tool, through a partnership between public and private entities, for the validation of CTUs selected to conduct FTIH trials. A feasibility form, encompassing nine sections, was created to gather information on the unit in relation to key attributes of FTIH trials. Collaboratively, industry and academic partners defined the minimal criteria to ensure the adherence of CTUs to the principles of ICH GCP and regulations outlined by the European Medicines Agency (EMA) for the execution of FTIH trials. Subsequently, all CTUs available for the project were assessed for FTIH trial eligibility. The introduction of the certification procedure through the feasibility tool within ERA4TB resulted in the accreditation of the five academic CTUs, which are now prepared to carry out FTIH trials as part of the Consortium. The developed feasibility tool aims to establish open and widely used minimum requirements for the validation of academic CTUs as FTIH units, marking it as the inaugural tool for CTU validation resulting from the collaboration between industry and academia within the ERA4TB project. The established partnership has enabled an innovative and novel way of working. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Prognostic Value of Platelet-to-Lymphocyte Ratio for Hepatocellular Carcinoma in Hispanic Population

Author

Dominguez-Dominguez, Mariela J., primary, Maldonado Lagunas, Vilma, additional, Alvarez-Bañuelos, María Teresa, additional, Sampieri-Ramírez, Clara L., additional, Garcia-Roman, Jonathan, additional, Montero, Hilda, additional, Campos-Parra, Alma D., additional, Dominguez-Lazcano, Diana G., additional, Rodriguez-Padron, Angela, additional, OrtizLeón, Maria Cristina, additional, Hurtado-Capetillo, Jose Manuel, additional, Morales-Velazquez, Jose L., additional, Lopez-Garcia, Nubia L., additional, Severino-Quintana, Emmanuel, additional, Alarcon-Rojas, Carlos A., additional, Fierro-Piñeros, Yeimi N., additional, Quintana-Prieto, Paula S., additional, Tello-Rojas, Marianna, additional, and García-Román, R., additional

Published
2023
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32. Prácticas de alimentación del lactante y del niño pequeño en tres instituciones de salud en el Caribe colombiano, bajo la estrategia 'Instituciones amigas de la mujer y la infancia integral'

Author

Millán, Nancy Haydeé, Castro Prieto, Paula Andrea, Fernández, Sonia Cristina, Arocha, Gina Paola, and Centre d'Estudis Demogràfics

Subjects
Instituciones amigas de la mujer y la infancia integral (Unicef), Iniciativa Hospital Amigo da Criança, Epidemiology, Breastfeeding, Nutrición de lactante, Complementary feeding, lactancia materna, nutrición de lactante, Community networks, Infant nutrition, Redes comunitarias, Health Information Management, Nutrição infantil, “instituciones amigas de la mujer y la infancia integral” (unicef), cuidado del niño, Lactância materna, Childcare, Lactancia materna, Health Policy, Redes comunitárias, Public Health, Environmental and Occupational Health, Baby friendly hospital strategy, Alimentação complementar, Cuidado infantil, Cuidado del niño, redes comunitarias, Alimentación complementaria, alimentación complementaria, Public aspects of medicine, RA1-1270
Abstract

Este trabajo parte de un avance del estudio sobre los determinantes sociodemográficos de la salud asociados con el estado nutricional en Colombia, elaborado por la estudiante Paula Castro, en el marco del programa de Doctorado en Demografía, del Centre d'Estudis Demogràfics, Universitat Autònoma de Barcelona (España), y que ha sido ampliado en concurso con los demás autores del presente artículo Describir las prácticas de alimentación de niños lactantes y de niños pequeños atendidos en instituciones de tres municipios del Caribe colombiano, incluidos en el proceso de implementación de la estrategia "Instituciones amigas de la mujer y la infancia integral" de la Unicef. Metodología: Estudio cualitativo enmarcado en la etnografía, llevado a cabo mediante entrevistas semiestructuradas, cartografía social y grupos focales, dirigido a madres beneficiarias de instituciones de salud priorizadas. Resultados: Las madres reconocieron los beneficios nutricionales de la lactancia materna, y en dos de los territorios, los beneficios emocionales. Además, presentan apropiación en lo relacionado con la alimentación perceptiva. No obstante, no cumplen con el periodo de exclusividad de la lactancia, refieren algunas creencias populares acerca de la misma y se observa un inicio temprano de la alimentación complementaria. También reconocieron la importancia de las redes de apoyo familiar y social, como, por ejemplo, del Instituto Colombiano de Bienestar Familiar. Conclusión: Esta investigación permitió reconocer factores que favorecen y limitan las adecuadas prácticas de alimentación del lactante y del niño pequeño, en madres gestantes y lactantes y su red de apoyo, las cuales viven en condiciones de vulnerabilidad social y económica, y son atendidas en tres instituciones de salud del Caribe colombiano que se encuentran en proceso de implementación de la estrategia enunciada. Lo anterior brinda elementos para la formulación de procesos educativos en salud para la población materno infantil, tanto en la población objetivo como en instituciones que se encuentren en proceso de implementación de dicha estrategia, y de requerimientos políticos acerca de la salud materno infantil. Objective: Describe the infant and young child feeding practices of children cared for in institutions of the Colombian Caribbean, includes in implementing the baby friendly hospital strategy. Methods: Qualitative study framed in ethnography through semi-structured interviews, aimed at beneficiary mothers of prioritized health institutions. Results: The mothers recognized the nutrtitionals benefits of breastfeeding, in two territories also the emotional benefits. They also show appropriation in relation to perceptual feeding. However, they do not comply with the exclusive period of breastfeeding, they refer to some beliefs around it, an early start of complementary feeding is observed. In turn, the mothers recognized the importance of family and social support networks, such as the Instituto Colombiano de Bienestar Familiar. Conclusion: This research made it possible to recognize factors that favor and limit the adequate feeding practices of infants and young children, in pregnant and lactating mothers and their support network, who live in conditions of social and economic vulnerability and are cared for in three health institutions of the Colombian Caribbean that are in the process of implementing the babyfriendly hospitals initiative. The foregoing provides elements for the formulation of educational processes in health in the maternal and child population, both in the target population and in institutions that are in the process of implementing the baby-friendly hospitals initiative and policies to maternal and child health. Objetivo: Descrever as práticas alimentares de lactentes e crianças atendidas em instituições de três municípios do Caribe colombiano, incluídas no processo de implementação da estratégia do Unicef "Instituições Amigas da Mulher e Infância Integral". Métodos: Estudo qualitativo enquadrado na etnografia, realizado por meio de entrevistas semiestruturadas, cartografia social e grupos focais, dirigido a mães beneficiárias de instituições de saúde priorizadas. Resultados: As mães reconheceram os benefícios nutricionais da amamentação e, em dois dos territórios, os benefícios emocionais. Além disso, apresentam apropriação em relação à alimentação perceptiva. Porém, não cumprem o período exclusivo de aleitamento materno, referem-se a algumas crenças populares a respeito, e observa-se o início precoce da alimentação complementar. Também reconheceram a importância das redes de apoio familiar e social, como o Instituto Colombiano de Bem-Estar Familiar. Conclusão: Esta pesquisa permitiu reconhecer fatores que favorecem e limitam as práticas alimentares adequadas de lactentes e crianças pequenas, em gestantes e lactantes e sua rede de apoio, que vivem em condições de vulnerabilidade social e econômica, sendo atendidas em três. Instituições de saúde do Caribe colombiano que estão em processo de implementação da estratégia declarada. O exposto fornece elementos para a formulação de processos educativos em saúde para a população materno-infantil, tanto na população-alvo como nas instituições que estão em processo de implementação dessa estratégia, e de requisitos políticos relativos à saúde materno-infantil.

Published
2021

34. Efecto del control estratégico de la garrapata común del bovino Rhipicephalus (Boophilus) microplus sobre la ganancia de peso en vaquillas Braford en el noreste de Argentina

Author

Rossner, Maria Victoria, Torrents, Jorgelina, Morel, Nicolas, Prieto, Paula Noelia, Lottero, F., Mangold, Atilio Jose, and Nava, Santiago

Subjects
Rhipicephalus (Boophilus) microplus, Garrapatas, Región Noroeste, Argentina, Weight Gain, Ticks, Raza Braford, Plagas de Animales, Ganado Bovino, Control de Plagas, Rhipicephalus, Metastigmata, Ganancia de Peso, Cattle, Pest Control, Pests of Animals
Abstract

El objetivo de este trabajo fue analizar el impacto del control estratégico de Rhipicephalus microplus sobre la ganancia de peso de vaquillas Braford en el noreste de Argentina. Se realizaron dos experimentos con un diseño similar en localidades de Corrientes (Colonia Tabay) y Chaco (Colonia Benítez). Los distintos grupos de vaquillas fueron sujetos a esquemas de control estratégico que consistieron en la aplicación de tres o cuatro productos garrapaticidas entre agosto y diciembre, y se compararon el número de garrapatas y la ganancia diaria de peso (GDP) entre estos y un grupo testigo que no recibió garrapaticidas. En Colonia Tabay, en los dos grupos tratados con esquemas de control estratégico la GDP fue significativamente mayor que en el grupo testigo con mayor nivel de infestación con garrapatas. El grupo sujeto a control estratégico en Colonia Benítez también tuvo una GDP significativamente mayor que el grupo testigo. Las diferencias en las GDP entre los grupos de animales sujetos a control estratégico y aquellos mantenidos como grupos testigo fluctuó entre 0.09 y 0.149 kg/día. Para el período evaluado en este trabajo (nueve meses), la aplicación del control estratégico contra R. microplus implicó una ganancia diferencial con respecto a los grupos sin tratamientos de 29 y 42 kg en promedio en las vaquillas de Colonia Tabay y de 25 kg en aquellas de Colonia Benítez. De los resultados se desprende que la aplicación de esquemas de tratamientos estratégicos para controlar la infestación con R. microplus en el noreste de Argentina contribuye a disminuir significativamente la abundancia de garrapatas y posibilita obtener mejores ganancias de peso vivo en bovinos en crecimiento al prevenir altos niveles de parasitación en los animales. The objective of this study was to analyze the impact of the strategic control of Rhipicephalus microplus on body weight gain of Braford heifers in northeastern Argentina. Two experiments with a similar design were carried out in Corrientes (Colonia Tabay) and Chaco (Colonia Benítez) Provinces. Strategic control schemes were applied different groups of heifers with the application of three or four treatments with chemical acaricides between August and December, and the number of ticks and the daily weight gain (GDP) were compared between them and with a control group without treatments. In Colonia Tabay, the GDP in the two groups treated with strategic control schemes was significantly higher than in the control group, which had higher level of infestation with ticks. The group subjected to strategic control in Colonia Benítez also had a significantly higher GDP than the control group. Differences in GDP between groups subjected to strategic control and control groups fluctuated between 0.09 and 0.149 kg/day. The application of strategic control against R. microplus implied a differential mean weight gain regarding the groups without treatments of 29 and 42 kg in Colonia Tabay heifers and 25 kg in Colonia Benítez. The results show that the application of strategic treatment schemes to control infestation with R. microplus in northeastern Argentina contributes to significantly reduce the abundance of ticks and enable obtain better body weight gains in growing cattle by preventing high levels of parasitism on animals. EEA Colonia Benitez EEA Rafaela Fil: Rossner, Maria Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benítez; Argentina Fil: Torrents, Jorgelina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina Fil: Morel, Nicolas. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Morel, Nicolas. Instituto de Investigación de la Cadena Láctea (IDICAL, INTA-CONICET); Argentina Fil: Prieto, Paula Noelia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benítez; Argentina Fil: Lottero, F. Fundación Correntina para la Sanidad Animal; Argentina Fil: Mangold, Atilio José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Mangold, Atilio José. Instituto de Investigación de la Cadena Láctea (IDICAL, INTA-CONICET); Argentina Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Nava, Santiago. Instituto de Investigación de la Cadena Láctea (IDICAL, INTA-CONICET); Argentina

Published
2022

41. Reorganización de la Unidad de investigación cualitativa – Centro Nacional de Consultoría

Author

Chica Prieto, Paula Camila, Ochoa Hernández, Yesid Alberto, and Universidad Santo Tomás

Subjects
Market research, Consultancy Centro Nacional de Consultoría, Plan de mejoramiento empresarial, Investigación cualitativa, Qualitative research, Business improvement plan, Business Innovation, Labor practices, Prácticas laborales, Consultoría Centro Nacional de Consultoría, Innovación empresarial, Investigación de mercados
Abstract

El siguiente trabajo es presentado como plan de mejora empresarial, basado en las experiencias y aprendizajes de la práctica laboral llevada a cabo por medio de un contrato laboral con el Centro Nacional de Consultoría, empresa privada dedicada a la investigación de mercados, social y expertos en opinión pública. Donde se apropió de diferentes situaciones con apoyo en los conocimientos adquiridos durante la carrera para llevar a cabo los objetivos propuestos en las investigaciones realizadas. En este plan de mejora empresarial se verá reflejado el fruto de año y medio de trabajo buscando mejorar y proponer procesos innovadores que responden a las necesidades de una empresa en crecimiento que plantea soluciones y respuestas a compañías públicas y privadas que buscan una respuesta. Profesional en Negocios Internacionales http://unidadinvestigacion.usta.edu.co Pregrado

Published
2021

42. Total and Unbound Doravirine Concentrations and Viral Suppression in CSF

Author

Tiraboschi, Juan, primary, Scévola, Sofia, additional, Penchala, Sujan Dilly, additional, Challenger, Elisabeth, additional, Else, Laura, additional, Prieto, Paula, additional, Saumoy, Maria, additional, Imaz, Arkaitz, additional, Silva-Klug, Ana, additional, Niubó, Jordi, additional, Soriano, Irene, additional, Khoo, Saye, additional, Rigo-Bonin, Raul, additional, and Podzamczer, Daniel, additional

Published
2021
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43. Chems4EU: chemsex use and its impacts across four European countries in HIV‐positive men who have sex with men attending HIV services

Author

Whitlock, Gary G., primary, Protopapas, Konstantinos, additional, Bernardino, Jose I., additional, Imaz, Arkaitz, additional, Curran, Adrian, additional, Stingone, Christof, additional, Shivasankar, Sivapatham, additional, Edwards, Sarah, additional, Herbert, Sophie, additional, Thomas, Konstantinos, additional, Mican, Rafael, additional, Prieto, Paula, additional, Nestor Garcia, Jorge, additional, Andreoni, Massimo, additional, Hill, Samantha, additional, Okhai, Hajra, additional, Stuart, David, additional, Bourne, Adam, additional, and Conway, Katie, additional

Published
2021
Full Text
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44. Prácticas de alimentación del lactante y del niño pequeño en tres instituciones de salud en el Caribe colombiano, bajo la estrategia “Instituciones amigas de la mujer y la infancia integral”

Author

Millán Echevarría, Nancy Haydeé, Castro Prieto, Paula Andrea, Fernández Fernández, Cristina, Arocha Zuluaga, Gina Paola, Millán Echevarría, Nancy Haydeé, Castro Prieto, Paula Andrea, Fernández Fernández, Cristina, and Arocha Zuluaga, Gina Paola

Abstract

Objective: Describe the infant and young child feeding practices of children cared for in institutions of the Colombian Caribbean, includes in implementing the baby friendly hospital strategy. Methodology: Qualitative study framed in ethnography through semi-structured interviews, aimed at beneficiary mothers of prioritized health institutions. Results: The mothers recognized the nutrtitionals benefits of breastfeeding, in two territories also the emotional benefits. They also show appropriation in relation to perceptual feeding. However, they do not comply with the exclusive period of breastfeeding, they refer to some beliefs around it, an early start of complementary feeding is observed. In turn, the mothers recognized the importance of family and social support networks, such as the Instituto Colombiano de Bienestar Familiar. Conclusion: This research made it possible to recognize factors that favor and limit the adequate feeding practices of infants and young children, in pregnant and lactating mothers and their support network, who live in conditions of social and economic vulnerability and are cared for in three health institutions of the Colombian Caribbean that are in the process of implementing the baby-friendly hospitals initiative. The foregoing provides elements for the formulation of educational processes in health in the maternal and child population, both in the target population and in institutions that are in the process of implementing the baby-friendly hospitals initiative and policies to maternal and child health., Objetivo: Descrever as práticas alimentares de lactentes e crianças atendidas em instituições de três municípios do Caribe colombiano, incluídas no processo de implementação da estratégia do Unicef “Instituições Amigas da Mulher e Infância Integral”. Metodologia: Estudo qualitativo enquadrado na etnografia, realizado por meio de entrevistas semiestruturadas, cartografia social e grupos focais, dirigido a mães beneficiárias de instituições de saúde priorizadas. Resultados: As mães reconheceram os benefícios nutricionais da amamentação e, em dois dos territórios, os benefícios emocionais. Além disso, apresentam apropriação em relação à alimentação perceptiva. Porém, não cumprem o período exclusivo de aleitamento materno, referem-se a algumas crenças populares a respeito, e observa-se o início precoce da alimentação complementar. Também reconheceram a importância das redes de apoio familiar e social, como o Instituto Colombiano de Bem-Estar Familiar. Conclusão: Esta pesquisa permitiu reconhecer fatores que favorecem e limitam as práticas alimentares adequadas de lactentes e crianças pequenas, em gestantes e lactantes e sua rede de apoio, que vivem em condições de vulnerabilidade social e econômica, sendo atendidas em três. Instituições de saúde do Caribe colombiano que estão em processo de implementação da estratégia declarada. O exposto fornece elementos para a formulação de processos educativos em saúde para a população materno-infantil, tanto na população-alvo como nas instituições que estão em processo de implementação dessa estratégia, e de requisitos políticos relativos à saúde materno-infantil., Objetivo: Describir las prácticas de alimentación de niños lactantes y de niños pequeños atendidos en instituciones de tres municipios del Caribe colombiano, incluidos en el proceso de implementación de la estrategia “Instituciones amigas de la mujer y la infancia integral” de la Unicef. Metodología: Estudio cualitativo enmarcado en la etnografía, llevado a cabo mediante entrevistas semiestructuradas, cartografía social y grupos focales, dirigido a madres beneficiarias de instituciones de salud priorizadas. Resultados: Las madres reconocieron los beneficios nutricionales de la lactancia materna, y en dos de los territorios, los beneficios emocionales. Además, presentan apropiación en lo relacionado con la alimentación perceptiva. No obstante, no cumplen con el periodo de exclusividad de la lactancia, refieren algunas creencias populares acerca de la misma y se observa un inicio temprano de la alimentación complementaria. También reconocieron la importancia de las redes de apoyo familiar y social, como, por ejemplo, del Instituto Colombiano de Bienestar Familiar. Conclusión: permitió reconocer factores que favorecen y limitan las adecuadas prácticas de alimentación del lactante y del niño pequeño, en madres gestantes y lactantes y su red de apoyo, las cuales viven en condiciones de vulnerabilidad social y económica, y son atendidas en tres instituciones de salud del Caribe colombiano que se encuentran en proceso de implementación de la estrategia enunciada. Lo anterior brinda elementos para la formulación de procesos educativos en salud para la población materno infantil, tanto en la población objetivo como en instituciones que se encuentren en proceso de implementación de dicha estrategia

Published
2021

45. Developmental patterns and rates of organogenesis across modern and well-adapted wheat cultivars

Author

European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Universidad de Lleida, Ochagavía, Helga [0000-0002-1050-681X], Ochagavía, Helga, Prieto, Paula, Savin, Roxana, Slafer, Gustavo A., European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Universidad de Lleida, Ochagavía, Helga [0000-0002-1050-681X], Ochagavía, Helga, Prieto, Paula, Savin, Roxana, and Slafer, Gustavo A.

Abstract

Genetic gains in wheat yield are required to meet future demand. In order to design strategic crosses, it is essential to quantify the genetic variation among elite cultivars on traits responsible for the adaptation and the generation of yield components. We explored the degree of variation within well-adapted commercial cultivars on developmental phases (vegetative, early reproductive and late reproductive), final leaf number and phyllochron, leaf and spikelet plastochron, number of spikelets, florets, and dynamics of floret primordia development. Variation in flowering time among cultivars was minor but they differed in the partitioning of that time into particular phases. Main differences were found for the length of the late reproductive phase, partly linked to those in final leaf number. Variations on number of fertile florets at anthesis were mostly explained by floret survival, due to differential ability of labile florets to maintain normal development between cultivars. These differences were related to the duration of the floret development, but not to the synchrony of development among florets. These findings provide useful information for breeders when selecting genotypes for strategic crosses, as considering floret survival through duration of floret development in one of the parents (for which these processes shall be characterised in the elite germplasm) might increase the likelihood of transgressive segregation towards high-yielding offspring.

Published
2021

46. Chems4EU: chemsex use and its impacts across four European countries in HIV-positive men who have sex with men attending HIV services

Author

Whitlock, Gary G. Protopapas, Konstantinos Bernardino, I, Jose and Imaz, Arkaitz Curran, Adrian Stingone, Christof and Shivasankar, Sivapatham Edwards, Sarah Herbert, Sophie and Thomas, Konstantinos Mican, Rafael Prieto, Paula Garcia, Jorge Nestor Andreoni, Massimo Hill, Samantha Okhai, Hajra and Stuart, David Bourne, Adam Conway, Katie

Abstract

Introduction Chemsex in a European context is the use of any of the following drugs to facilitate sex: crystal methamphetamine, mephedrone and gamma-hydroxybutyrate (GHB)/gamma-butyrolactone (GBL) and, to a lesser extent, cocaine and ketamine. This study describes the prevalence of self-reported recreational drug use and chemsex in HIV-positive men who have sex with men (MSM) accessing HIV services in four countries. It also examines the problematic impacts and harms of chemsex and access to chemsex-related services. Methods This is a cross-sectional multi-centre questionnaire study of HIV-positive MSM accessing nine HIV services in the UK, Spain, Greece and Italy. Results In all, 1589 HIV-positive MSM attending HIV services in four countries completed the questionnaire. The median age of participants was 38 years (interquartile range: 32-46 years) and 1525 (96.0%) were taking antiretroviral therapy (ART). In the previous 12 months, 709 (44.6%) had used recreational drugs, 382 (24.0%) reported chemsex and 104 (6.5%) reported injection of chemsex-associated drugs (’slamsex’). Of the 382 engaging in chemsex, 155 (40.6%) reported unwanted side effects as a result of chemsex and 81 (21.2%) as a result of withdrawal from chemsex. The reported negative impacts from chemsex were on work (25.1%, 96), friends/family (24.3%, 93) and relationships (28.3%, 108). Fifty-seven (14.9%) accessed chemsex-related services in the past year, 38 of whom (67%) felt the service met their needs. Discussion A quarter of participants self-reported chemsex in the past 12 months. There were high rates of harms from chemsex across all countries, including negative impacts on work, friends/family and relationships. Although a minority of those engaging in chemsex accessed support, most found this useful.

Published
2021

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