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228 results on '"Priceman, Saul J."'

1. PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial

Author

Dorff, Tanya B., Blanchard, M. Suzette, Adkins, Lauren N., Luebbert, Laura, Leggett, Neena, Shishido, Stephanie N., Macias, Alan, Del Real, Marissa M., Dhapola, Gaurav, Egelston, Colt, Murad, John P., Rosa, Reginaldo, Paul, Jinny, Chaudhry, Ammar, Martirosyan, Hripsime, Gerdts, Ethan, Wagner, Jamie R., Stiller, Tracey, Tilakawardane, Dileshni, Pal, Sumanta, Martinez, Catalina, Reiter, Robert E., Budde, Lihua E., D’Apuzzo, Massimo, Kuhn, Peter, Pachter, Lior, Forman, Stephen J., and Priceman, Saul J.

Published
2024
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3. Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Author

Lee, Eric Hee Jun, Murad, John P., Christian, Lea, Gibson, Jackson, Yamaguchi, Yukiko, Cullen, Cody, Gumber, Diana, Park, Anthony K., Young, Cari, Monroy, Isabel, Yang, Jason, Stern, Lawrence A., Adkins, Lauren N., Dhapola, Gaurav, Gittins, Brenna, Chang, Wen-Chung, Martinez, Catalina, Woo, Yanghee, Cristea, Mihaela, Rodriguez-Rodriguez, Lorna, Ishihara, Jun, Lee, John K., Forman, Stephen J., Wang, Leo D., and Priceman, Saul J.

Published
2023
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4. Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy

Author

Bhatia, Vipul, Kamat, Nikhil V., Pariva, Tiffany E., Wu, Li-Ting, Tsao, Annabelle, Sasaki, Koichi, Sun, Huiyun, Javier, Gerardo, Nutt, Sam, Coleman, Ilsa, Hitchcock, Lauren, Zhang, Ailin, Rudoy, Dmytro, Gulati, Roman, Patel, Radhika A., Roudier, Martine P., True, Lawrence D., Srivastava, Shivani, Morrissey, Colm M., Haffner, Michael C., Nelson, Peter S., Priceman, Saul J., Ishihara, Jun, and Lee, John K.

Published
2023
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7. Contributors

Author

Abreu, Maria M., primary, Adusumilli, Prasad S., additional, Badie, Behnam, additional, Basar, Rafet, additional, Bellis, Rebecca, additional, Blasberg, Ronald, additional, Breznik, Barbara, additional, Chaurasiya, Shyambabu, additional, Chen, Po-Chun, additional, Choong, Kevin, additional, Chovatiya, Nishant, additional, Daher, May, additional, Deshpande, Supriya, additional, Feldman, Lisa, additional, Folsom, Timothy D., additional, Fong, Christina, additional, Fong, Yuman, additional, Gouvea, Jacqueline, additional, Habič, Anamarija, additional, Jewett, Anahid, additional, Katz, Sharyn I., additional, Kaur, Kawaljit, additional, Ko, Meng-Wei, additional, Kos, Janko, additional, Lee, Derek, additional, Li, Zhe, additional, Lou, Emil, additional, Maharaj, Dipnarine, additional, Mahuron, Kelly, additional, Majc, Bernarda, additional, Matosevic, Sandro, additional, Moriarity, Branden S., additional, Murad, John P., additional, Navin, Ishwar, additional, Novak, Metka, additional, Parihar, Robin, additional, Park, Anthony K., additional, Polineni, Vineet, additional, Ponomarev, Vladimir, additional, Priceman, Saul J., additional, Rafei, Hind, additional, Rand, Jamie, additional, Rezvani, Katayoun, additional, Rivière, Isabelle, additional, Roshkovan, Leonid, additional, Sadeghi, Saeed, additional, Saini, Jasmeen, additional, Senjor, Emanuela, additional, Serganova, Inna, additional, Starr, Timothy K., additional, Turnsek, Tamara Lah, additional, Volpe, Alessia, additional, Wang, Xiuyan, additional, Webber, Beau R., additional, Wong, Paul, additional, Woo, Yanghee, additional, Wu, Jennifer, additional, Yang, Lili, additional, Yuan, Yuan, additional, Zeng, Samuel, additional, and Zhu, Amy, additional

Published
2023
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11. Author response: Regulation of nuclear transcription by mitochondrial RNA in endothelial cells

Author

Sriram, Kiran, primary, Qi, Zhijie, additional, Yuan, Dongqiang, additional, Malhi, Naseeb Kaur, additional, Liu, Xuejing, additional, Calandrelli, Riccardo, additional, Luo, Yingjun, additional, Tapia, Alonso, additional, Jin, Shengyan, additional, Shi, Ji, additional, Salas, Martha, additional, Dang, Runrui, additional, Armstrong, Brian, additional, Priceman, Saul J, additional, Wang, Ping H, additional, Liao, Jiayu, additional, Natarajan, Rama, additional, Zhong, Sheng, additional, and Bouman Chen, Zhen, additional

Published
2023
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12. Hyperthermic Intraperitoneal Chemotherapy–Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer

Author

Dellinger, Thanh H., Han, Ernest S., Raoof, Mustafa, Lee, Byrne, Wu, Xiwei, Cho, Hyejin, He, Ting-Fang, Lee, Peter, Razavi, Marianne, Liang, Winnie S., Schmolze, Daniel, Priceman, Saul J., Lee, Stephen, Lin, Wei-Chien, Lin, Jeff F., Kebria, Mehdi, Hakim, Amy, Ruel, Nora, Stewart, Daphne B., Wang, Edward W., Paz, Benjamin I., Wakabayashi, Mark T., Cristea, Mihaela C., and Rodriguez-Rodriguez, Lorna

Published
2022
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13. CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, Schokrpur, Shiruyeh, Liu, Connie, Priceman, Saul J, Moughon, Diana, Jiang, Ziyue, Pouliot, Frederic, Magyar, Clara, Sung, James L, Xu, Jingying, Deng, Gang, West, Brian L, Bollag, Gideon, Fradet, Yves, Lacombe, Louis, Jung, Michael E, Huang, Jiaoti, and Wu, Lily

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Urologic Diseases, Prostate Cancer, Aetiology, 2.1 Biological and endogenous factors, Androgen Antagonists, Animals, Carcinogenesis, Cells, Cultured, Drug Resistance, Neoplasm, Humans, Macrophages, Male, Mice, Prostatic Neoplasms, Receptor, Macrophage Colony-Stimulating Factor, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Growing evidence suggests that tumor-associated macrophages (TAM) promote cancer progression and therapeutic resistance by enhancing angiogenesis, matrix-remodeling, and immunosuppression. In this study, prostate cancer under androgen blockade therapy (ABT) was investigated, demonstrating that TAMs contribute to prostate cancer disease recurrence through paracrine signaling processes. ABT induced the tumor cells to express macrophage colony-stimulating factor 1 (M-CSF1 or CSF1) and other cytokines that recruit and modulate macrophages, causing a significant increase in TAM infiltration. Inhibitors of CSF1 signaling through its receptor, CSF1R, were tested in combination with ABT, demonstrating that blockade of TAM influx in this setting disrupts tumor promotion and sustains a more durable therapeutic response compared with ABT alone.

Published
2015

14. Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression

Author

Garcia, Alejandro J, Ruscetti, Marcus, Arenzana, Teresita L, Tran, Linh M, Bianci-Frias, Daniella, Sybert, Elysia, Priceman, Saul J, Wu, Lily, Nelson, Peter S, Smale, Stephen T, and Wu, Hong

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Urologic Diseases, Aging, Prostate Cancer, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Animals, Anisoles, Arginase, CD11b Antigen, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Epithelium, Immune Tolerance, Inflammation, Interleukin-1beta, Lymphocyte Activation, Macrophage Colony-Stimulating Factor, Male, Mice, Mice, Transgenic, Myeloid Cells, Nitric Oxide Synthase Type II, PTEN Phosphohydrolase, Prostate, Prostatic Neoplasms, Pyrimidines, Receptors, Chemokine, Signal Transduction, Spleen, T-Lymphocytes, Up-Regulation, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Chronic inflammation is known to be associated with prostate cancer development, but how epithelium-associated cancer-initiating events cross talk to inflammatory cells during prostate cancer initiation and progression is largely unknown. Using the Pten null murine prostate cancer model, we show an expansion of Gr-1(+) CD11b(+) myeloid-derived suppressor cells (MDSCs) occurring intraprostatically immediately following epithelium-specific Pten deletion without expansion in hematopoietic tissues. This MDSC expansion is accompanied by sustained immune suppression. Prostatic Gr-1(+) CD11b(+) cells, but not those isolated from the spleen of the same tumor-bearing mice, suppress T cell proliferation and express high levels of Arginase 1 and iNOS. Mechanistically, the loss of PTEN in the epithelium leads to a significant upregulation of genes within the inflammatory response and cytokine-cytokine receptor interaction pathways, including Csf1 and Il1b, two genes known to induce MDSC expansion and immunosuppressive activities. Treatment of Pten null mice with the selective CSF-1 receptor inhibitor GW2580 decreases MDSC infiltration and relieves the associated immunosuppressive phenotype. Our study indicates that epithelium-associated tumor-initiating events trigger the secretion of inflammatory cytokines and promote localized MDSC expansion and immune suppression, thereby promoting tumor progression.

Published
2014

18. Data from The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma

Author

Wang, Xiuli, primary, Huynh, Christian, primary, Urak, Ryan, primary, Weng, Lihong, primary, Walter, Miriam, primary, Lim, Laura, primary, Vyas, Vibhuti, primary, Chang, Wen-Chung, primary, Aguilar, Brenda, primary, Brito, Alfonso, primary, Sarkissian, Aniee, primary, Bandara, N. Achini, primary, Yang, Lu, primary, Wang, Jinhui, primary, Wu, Xiwei, primary, Zhang, Jianying, primary, Priceman, Saul J., primary, Qin, Hong, primary, Kwak, Larry W., primary, Budde, Lihua E., primary, Thomas, Sandra H., primary, Clark, Mary C., primary, Popplewell, Leslie, primary, Siddiqi, Tanya, primary, Brown, Christine E., primary, and Forman, Stephen J., primary

Published
2023
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21. Abstract 4090: Regional administration of IL-12 endowed CAR T cells effectively targets systemic disease

Author

Lee, Hee Jun, primary, Yamaguchi, Yuki, additional, Gibson, Jackson, additional, Cullen, Cody, additional, Murad, John P., additional, Park, Anthony K., additional, Monroy, Isabel, additional, Young, Cari, additional, Christian, Lea, additional, Adkins, Lauren, additional, Stern, Lawrence, additional, Chang, Wen-Chung, additional, Martinez, Catalina, additional, Forman, Stephen J., additional, and Priceman, Saul J., additional

Published
2023
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22. Supplementary Figures from The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma

Author

Wang, Xiuli, primary, Huynh, Christian, primary, Urak, Ryan, primary, Weng, Lihong, primary, Walter, Miriam, primary, Lim, Laura, primary, Vyas, Vibhuti, primary, Chang, Wen-Chung, primary, Aguilar, Brenda, primary, Brito, Alfonso, primary, Sarkissian, Aniee, primary, Bandara, N. Achini, primary, Yang, Lu, primary, Wang, Jinhui, primary, Wu, Xiwei, primary, Zhang, Jianying, primary, Priceman, Saul J., primary, Qin, Hong, primary, Kwak, Larry W., primary, Budde, Lihua E., primary, Thomas, Sandra H., primary, Clark, Mary C., primary, Popplewell, Leslie, primary, Siddiqi, Tanya, primary, Brown, Christine E., primary, and Forman, Stephen J., primary

Published
2023
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28. Figure S1 from Recombinant Orthopoxvirus Primes Colon Cancer for Checkpoint Inhibitor and Cross-Primes T Cells for Antitumor and Antiviral Immunity

Author

Kim, Sang-In, primary, Park, Anthony K., primary, Chaurasiya, Shyambabu, primary, Kang, Seonah, primary, Lu, Jianming, primary, Yang, Annie, primary, Sivanandam, Venkatesh, primary, Zhang, Zhifang, primary, Woo, Yanghee, primary, Priceman, Saul J., primary, Fong, Yuman, primary, and Warner, Susanne G., primary

Published
2023
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29. Figure S1, Figure S2, Figure S3, Figure S4 from Regional Delivery of Chimeric Antigen Receptor–Engineered T Cells Effectively Targets HER2+ Breast Cancer Metastasis to the Brain

Author

Priceman, Saul J., primary, Tilakawardane, Dileshni, primary, Jeang, Brook, primary, Aguilar, Brenda, primary, Murad, John P., primary, Park, Anthony K., primary, Chang, Wen-Chung, primary, Ostberg, Julie R., primary, Neman, Josh, primary, Jandial, Rahul, primary, Portnow, Jana, primary, Forman, Stephen J., primary, and Brown, Christine E., primary

Published
2023
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30. Supplementary Materials and Methods from Targeting Alpha-Fetoprotein (AFP)–MHC Complex with CAR T-Cell Therapy for Liver Cancer

Author

Liu, Hong, primary, Xu, Yiyang, primary, Xiang, Jingyi, primary, Long, Li, primary, Green, Shon, primary, Yang, Zhiyuan, primary, Zimdahl, Bryan, primary, Lu, Jingwei, primary, Cheng, Neal, primary, Horan, Lucas H., primary, Liu, Bin, primary, Yan, Su, primary, Wang, Pei, primary, Diaz, Juan, primary, Jin, Lu, primary, Nakano, Yoko, primary, Morales, Javier F., primary, Zhang, Pengbo, primary, Liu, Lian-xing, primary, Staley, Binnaz K., primary, Priceman, Saul J., primary, Brown, Christine E., primary, Forman, Stephen J., primary, Chan, Vivien W., primary, and Liu, Cheng, primary

Published
2023
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31. Supplemental Figure 6 from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, primary, Schokrpur, Shiruyeh, primary, Liu, Connie, primary, Priceman, Saul J., primary, Moughon, Diana, primary, Jiang, Ziyue, primary, Pouliot, Frederic, primary, Magyar, Clara, primary, Sung, James L., primary, Xu, Jingying, primary, Deng, Gang, primary, West, Brian L., primary, Bollag, Gideon, primary, Fradet, Yves, primary, Lacombe, Louis, primary, Jung, Michael E., primary, Huang, Jiaoti, primary, and Wu, Lily, primary

Published
2023
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32. Data from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, primary, Schokrpur, Shiruyeh, primary, Liu, Connie, primary, Priceman, Saul J., primary, Moughon, Diana, primary, Jiang, Ziyue, primary, Pouliot, Frederic, primary, Magyar, Clara, primary, Sung, James L., primary, Xu, Jingying, primary, Deng, Gang, primary, West, Brian L., primary, Bollag, Gideon, primary, Fradet, Yves, primary, Lacombe, Louis, primary, Jung, Michael E., primary, Huang, Jiaoti, primary, and Wu, Lily, primary

Published
2023
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33. Supplementary Figures 1-5 from The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer

Author

Sloan, Erica K., primary, Priceman, Saul J., primary, Cox, Benjamin F., primary, Yu, Stephanie, primary, Pimentel, Matthew A., primary, Tangkanangnukul, Veera, primary, Arevalo, Jesusa M.G., primary, Morizono, Kouki, primary, Karanikolas, Breanne D.W., primary, Wu, Lily, primary, Sood, Anil K., primary, and Cole, Steven W., primary

Published
2023
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34. Supplemental Figure 4 from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, primary, Schokrpur, Shiruyeh, primary, Liu, Connie, primary, Priceman, Saul J., primary, Moughon, Diana, primary, Jiang, Ziyue, primary, Pouliot, Frederic, primary, Magyar, Clara, primary, Sung, James L., primary, Xu, Jingying, primary, Deng, Gang, primary, West, Brian L., primary, Bollag, Gideon, primary, Fradet, Yves, primary, Lacombe, Louis, primary, Jung, Michael E., primary, Huang, Jiaoti, primary, and Wu, Lily, primary

Published
2023
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35. Supplemental Figure 2 from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, primary, Schokrpur, Shiruyeh, primary, Liu, Connie, primary, Priceman, Saul J., primary, Moughon, Diana, primary, Jiang, Ziyue, primary, Pouliot, Frederic, primary, Magyar, Clara, primary, Sung, James L., primary, Xu, Jingying, primary, Deng, Gang, primary, West, Brian L., primary, Bollag, Gideon, primary, Fradet, Yves, primary, Lacombe, Louis, primary, Jung, Michael E., primary, Huang, Jiaoti, primary, and Wu, Lily, primary

Published
2023
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36. Supplemental Figure Legends from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, primary, Schokrpur, Shiruyeh, primary, Liu, Connie, primary, Priceman, Saul J., primary, Moughon, Diana, primary, Jiang, Ziyue, primary, Pouliot, Frederic, primary, Magyar, Clara, primary, Sung, James L., primary, Xu, Jingying, primary, Deng, Gang, primary, West, Brian L., primary, Bollag, Gideon, primary, Fradet, Yves, primary, Lacombe, Louis, primary, Jung, Michael E., primary, Huang, Jiaoti, primary, and Wu, Lily, primary

Published
2023
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37. Supplemental Figure 3 from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, primary, Schokrpur, Shiruyeh, primary, Liu, Connie, primary, Priceman, Saul J., primary, Moughon, Diana, primary, Jiang, Ziyue, primary, Pouliot, Frederic, primary, Magyar, Clara, primary, Sung, James L., primary, Xu, Jingying, primary, Deng, Gang, primary, West, Brian L., primary, Bollag, Gideon, primary, Fradet, Yves, primary, Lacombe, Louis, primary, Jung, Michael E., primary, Huang, Jiaoti, primary, and Wu, Lily, primary

Published
2023
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38. Supplemental Figure 1 from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, primary, Schokrpur, Shiruyeh, primary, Liu, Connie, primary, Priceman, Saul J., primary, Moughon, Diana, primary, Jiang, Ziyue, primary, Pouliot, Frederic, primary, Magyar, Clara, primary, Sung, James L., primary, Xu, Jingying, primary, Deng, Gang, primary, West, Brian L., primary, Bollag, Gideon, primary, Fradet, Yves, primary, Lacombe, Louis, primary, Jung, Michael E., primary, Huang, Jiaoti, primary, and Wu, Lily, primary

Published
2023
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41. Supplemental Figure 5 from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Author

Escamilla, Jemima, primary, Schokrpur, Shiruyeh, primary, Liu, Connie, primary, Priceman, Saul J., primary, Moughon, Diana, primary, Jiang, Ziyue, primary, Pouliot, Frederic, primary, Magyar, Clara, primary, Sung, James L., primary, Xu, Jingying, primary, Deng, Gang, primary, West, Brian L., primary, Bollag, Gideon, primary, Fradet, Yves, primary, Lacombe, Louis, primary, Jung, Michael E., primary, Huang, Jiaoti, primary, and Wu, Lily, primary

Published
2023
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43. Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Author

Jun Lee, Eric Hee, primary, Cullen, Cody, additional, Murad, John P., additional, Gumber, Diana, additional, Park, Anthony K., additional, Yang, Jason, additional, Stern, Lawrence A., additional, Adkins, Lauren N., additional, Dhapola, Gaurav, additional, Gittins, Brenna, additional, Chung-Chang, Wen, additional, Martinez, Catalina, additional, Woo, Yanghee, additional, Cristea, Mihaela, additional, Rodriguez-Rodriguez, Lorna, additional, Ishihara, Jun, additional, Lee, John K., additional, Forman, Stephen J., additional, Wang, Leo D., additional, and Priceman, Saul J., additional

Published
2023
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44. Regulation of Nuclear Transcription by Mitochondrial RNA

Author

Sriram, Kiran, primary, Qi, Zhijie, additional, Yuan, Dongqiang, additional, Malhi, Naseeb K., additional, Liu, Xuejing, additional, Calandrelli, Riccardo, additional, Luo, Yingjun, additional, Jin, Shengyan, additional, Shi, Ji, additional, Salas, Martha, additional, Dang, Runrui, additional, Armstrong, Brian, additional, Priceman, Saul J., additional, Wang, Ping, additional, Liao, Jiayu, additional, Natarajan, Rama, additional, Zhong, Sheng, additional, and Chen, Zhen B., additional

Published
2022
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48. PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages

Author

Yamaguchi, Yukiko, primary, Gibson, Jackson, additional, Ou, Kevin, additional, Lopez, Lupita S, additional, Ng, Rachel H, additional, Leggett, Neena, additional, Jonsson, Vanessa D, additional, Zarif, Jelani C, additional, Lee, Peter P, additional, Wang, Xiuli, additional, Martinez, Catalina, additional, Dorff, Tanya B, additional, Forman, Stephen J, additional, and Priceman, Saul J, additional

Published
2022
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49. Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell therapy

Author

Bhatia, Vipul, primary, Kamat, Nikhil V., additional, Pariva, Tiffany E., additional, Wu, Li-Ting, additional, Tsao, Annabelle, additional, Sasaki, Koichi, additional, Wiest, Lauren T., additional, Zhang, Ailin, additional, Rudoy, Dmytro, additional, Gulati, Roman, additional, Patel, Radhika A., additional, Roudier, Martine P., additional, True, Lawrence D., additional, Haffner, Michael C., additional, Nelson, Peter S., additional, Priceman, Saul J., additional, Ishihara, Jun, additional, and Lee, John K., additional

Published
2022
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