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2. Morphologies, metastability and coarsening of quantum nanoislands on the surfaces of the annealed Ag(110) and Pb(111) thin films

Author

Price, Donald L., Henner, Victor, and Khenner, Mikhail

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Mathematics - Analysis of PDEs, Nonlinear Sciences - Adaptation and Self-Organizing Systems, Nonlinear Sciences - Pattern Formation and Solitons
Abstract

Morphological evolution of heteroepitaxial nanoislands toward equilibrium (coarsening) is computed using the detailed continuum model that incorporates the quantum size effect. Results reveal the metastability of the "magic" heights, show the morphological transitions and the surface diffusion routes by which a quantum island reaches its stable height, and provide the coarsening laws for the island density and area, thus clarifying the kinetic morphology pathways in the growth of an ultrathin metal films., Comment: Accepted for publication in the Journal of Applied Physics

Published
2018
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8. Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

Author

Sze, Chun-I, Troncoso, Juan C, Kawas, Claudia, Mouton, Peter, Price, Donald L, and Martin, Lee J

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Behavioral and Social Science, Acquired Cognitive Impairment, Neurodegenerative, Aging, Brain Disorders, Alzheimer's Disease, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), 2.1 Biological and endogenous factors, Mental health, Neurological, Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Cognition Disorders, Female, Hippocampus, Humans, Immunoblotting, Male, Synaptophysin, Braak stage, CA1, memory loss, senile plaque, synapse, Neurology & Neurosurgery, Clinical sciences
Abstract

We tested the hypothesis that synaptic defects in the hippocampus of individuals with Alzheimer disease (AD) correlate with the severity of cognitive impairment. Three postmortem groups were studied: controls with normal and stable cognition; cognitively intact subjects with senile plaque densities diagnostic for possible AD (p-AD) and neurofibrillary changes characteristic of early AD (Braak stage III); and individuals with definite AD and neurofibrillary changes typical of incipient to severe AD (Braak stage III, V, or VI). Synaptophysin (a presynaptic vesicle protein) levels were quantified by immunoblotting of synaptic membrane fractions isolated from hippocampus, entorhinal cortex, caudate nucleus, and occipital cortex. Average synaptophysin levels were reduced in hippocampus when comparing definite AD to controls (55%, p < 0.0001), p-AD to control (25%, p < 0.005), and definite AD to p-AD (30%, p < 0.05), but levels in entorhinal cortex, occipital cortex, and caudate nucleus were either unchanged or less significantly altered than in hippocampus. By univariate analysis, hippocampal synaptophysin levels correlated with neuropsychological measurements, including Mini-mental state examination scores (r = 0.83, p < 0.0001) and Blessed scores (r = 0.74, P < 0.001), and with senile plaque densities (r = 0.89, p < 0.0001). We conclude that synaptic abnormalities in the hippocampus correlate with the severity of neuropathology and memory deficit in individuals with AD, and that this defect may predate neuropsychological evidence for cognitive impairment early in AD.

Published
1997

23. Vision for the future : Alzheimer’s Disease: Pathogenesis, Models and Experimental Therapeutics

Author

Price, Donald L., Li, Tong, Laird, Fiona M., Farah, Mohamed, Savonenko, Alena V., Lee, Michael, Troncoso, Juan, Wong, Philip C., Christen, Yves, editor, Agid, Yves, editor, Aguayo, Albert, editor, Anderton, Brian H., editor, Bartus, Raymond T., editor, Björklund, Anders, editor, Bloom, Floyd, editor, Boller, François, editor, Cotman, Carl, editor, Davies, Peter, editor, Delacourte, Andre, editor, Ferris, Steven, editor, Foncin, Jean-François, editor, Forette, Françoise, editor, Gage, Fred, editor, Goldgaber, Dmitry, editor, Hardy, John, editor, Hauw, Jean-Jacques, editor, Kordon, Claude, editor, Kosik, Kenneth S., editor, Mallet, Jacques, editor, Masters, Colin L., editor, Rapoport, Stanley I., editor, Reisberg, Barry, editor, Roses, Allen, editor, Selkoe, Dennis J., editor, Shelanski, Michael L., editor, Sinet, Pierre-Marie, editor, St. George-Hyslop, Peter, editor, Terry, Robert, editor, Zarifian, Edouard, editor, Jucker, Mathias, editor, Beyreuther, Konrad, editor, Haass, Christian, editor, and Nitsch, Roger M., editor

Published
2006
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32. In Vivo Biology of APP and its Homologues

Author

Sisodia, Sangram S., Thinakaran, Gopal, von Koch, Cornelia S., Slunt, Hilda H., Roskams, A. Jane I., Kitt, Cheryl A., Masliah, Eliezer, Koliatsos, Vassilis E., Mouton, Peter R., Martin, Lee J., Reed, Randall R., Ronnett, Gabrielle V., Zheng, Hui, Van der Ploeg, Lex H. T., Price, Donald L., Goldstein, Allan L., editor, Kumar, Ajit, editor, Bailey, J. Martyn, editor, and Fiskum, Gary, editor

Published
1996
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35. A

Author

Schubert, David, Barratt, Ernest S., Perry, George, Sisodia, Sangram S., Koo, Edward H., Price, Donald L., Kihlstrom, John F., Couture, Lawrence J., Schacter, Daniel L., Baines, Anthony J., Edelman, Shimon, Poggio, Tomaso, Ornitz, Edward M., Ochs, Sidney, Smith, Barry, editor, and Adelman, George, editor

Published
1992
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