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601 results on '"Previtera, Lucio"'

7. Newly Discovered Irbesartan Disinfection Byproducts via Chlorination: Investigating Potential Environmental Toxicity.

Author

Siciliano, Antonietta, Medici, Antonio, Guida, Marco, Libralato, Giovanni, Saviano, Lorenzo, Previtera, Lucio, Di Fabio, Giovanni, and Zarrelli, Armando

Subjects
WATER disinfection, WATER chlorination, IRBESARTAN, CHLORINATION, TYPE 2 diabetes, SEWAGE disposal plants, DAPHNIA magna
Abstract

Irbesartan belongs to the Sartan family, whose members are used in the treatment of arterial hypertension and kidney disease among patients with hypertension and type 2 diabetes mellitus as part of a treatment based on antihypertensive drugs. This drug has reached surface waters, accumulating to the extent of being considered an emerging pollutant, along with other substances from the same class. Wastewater treatment plants, which constitute the main environmental source of this compound, fail to completely reduce its presence in wastewater and generate additional toxic byproducts through the chlorine-based disinfection process. This study provides a comprehensive investigation into the chlorination mechanisms of irbesartan, revealing the identity of twelve new byproducts, which were characterized using NMR and mass spectrometry (MS-TOF). The other six byproducts were published in a previous study, allowing for the confirmation of some aspects of the supposed mechanisms of degradation, along with the identification of those that had only been hypothesized. An ecotoxicological assessment of a mixture and isolated byproducts was performed using Raphidocelis subcapitata for algal growth inhibition, Daphnia magna for immobility, and Aliivibrio fischeri for luminescence inhibition. The results revealed the variable toxicity of irbesartan and its byproducts. Different organisms exhibited varying sensitivities to the byproducts, with Aliivibrio fischeri being the most sensitive. The coexistence of multiple byproducts in the environment, their high toxicity, and their potential interactions highlight the significant environmental risks associated with chlorination and its derivates. Our study highlights the ongoing debate surrounding the generation of disinfection byproducts. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Solid-state photodimerization of steroid enones

Author

DellaGreca, Marina, Iesce, Maria Rosaria, Previtera, Lucio, Temussi, Fabio, Zarrelli, Armando, Mattia, Carlo Andrea, and Puliti, Raffaella

Subjects
Chemistry, Organic -- Research, Steroids (Drugs), Solid state chemistry -- Research, Photochemistry -- Research, Ultraviolet radiation -- Usage, Biological sciences, Chemistry
Abstract

Research has been conducted on androst-4-ene-3,17-dione and 17alpha-methyltestosterone. The dimerization of these compounds has been carried out in the solid-state via the use of UV radiation and the details are reported.

Published
2002

34. Solid-state photodimerization of cholest-4-en-3-one

Author

DellaGreca, Marina, Monaco, Pietro, Previtera, Lucio, Zarrelli, Armando, Fiorentino, Antonio, Giordano, Federico, and Mattia, Carlo Andrea

Subjects
Chemistry, Organic -- Research, Photochemical research -- Research, Ultraviolet radiation -- Usage, Solid state chemistry -- Research, Carbon -- Physiological aspects, Hydrogen -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the crystalline cholest-4-en-3-one. The results of the solid-state dimerization of this compound carried out via the UV radiation in producing two ring A-ring A connected dimers are described.

Published
2001

49. Solid-state photodimerization of 16-dehydroprogesterone

Author

DellaGreca, Marina, Monaco, Pietro, Previtera, Lucio, Fiorentino, Antonio, Giordano, Federico, and Mattia, Carlo

Subjects
Chemistry, Organic -- Research, Norethindrone -- Research, Biological sciences, Chemistry
Abstract

Research concerning photodimerization of norethisterone in a solid state through side chains has been conducted. Results indicate that the active radiation in the photoreaction is a quantitative participant of the process.

Published
1999

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