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6. Outcomes and predictive factors of successful salvage microdissection testicular sperm extraction (mTESE) after failed classic TESE: results from a multicenter cross-sectional study

Author

Boeri, Luca, Bebi, Carolina, Dente, Donato, Greco, Ermanno, Turetti, Matteo, Capece, Marco, Cocci, Andrea, Cito, Gianmartin, Preto, Mirko, Pescatori, Edoardo, Ciampaglia, Walter, Scroppo, Fabrizio Ildefonso, Falcone, Marco, Ceruti, Carlo, Gadda, Franco, Franco, Giorgio, Dehò, Federico, Palmieri, Alessandro, Rolle, Luigi, Gontero, Paolo, Montorsi, Francesco, Montanari, Emanuele, and Salonia, Andrea

Published
2022
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12. No difference between split-thickness and full-thickness skin grafts for surgical repair in adult acquired buried penis regarding surgical and functional outcomes: a comparative retrospective analysis

Author

Gül, Murat, primary, Plamadeala, Natalia, additional, Falcone, Marco, additional, Preto, Mirko, additional, Cirigliano, Lorenzo, additional, Peretti, Federica, additional, Ferro, Ilaria, additional, Scavone, Martina, additional, and Gontero, Paolo, additional

Published
2024
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13. Risk and benefits of penile length preservation techniques during penile prosthesis implantation: a systematic review by the young academic urologists sexual and reproductive health working group

Author

Falcone, Marco, primary, Preto, Mirko, additional, Morgado, Afonso Ribeiro, additional, Sokolakis, Ioannis, additional, Sarıkaya, Selçuk, additional, Capece, Marco, additional, Capogrosso, Paolo, additional, Manfredi, Celeste, additional, Tsampoukas, Georgios, additional, and Russo, Giorgio, additional

Published
2024
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14. Global Practice Patterns in the Evaluation of Non-Obstructive Azoospermia: Results of a World-Wide Survey and Expert Recommendations

Author

Shah, Rupin, primary, Rambhatla, Amarnath, additional, Atmoko, Widi, additional, Martinez, Marlon, additional, Ziouziou, Imad, additional, Kothari, Priyank, additional, Tadros, Nicholas, additional, Phuoc, Nguyen Ho Vinh, additional, Kavoussi, Parviz, additional, Harraz, Ahmed, additional, Salvio, Gianmaria, additional, Gul, Murat, additional, Hamoda, Taha, additional, Toprak, Tuncay, additional, Birowo, Ponco, additional, Ko, Edmund, additional, Arafa, Mohamed, additional, Ghayda, Ramy Abou, additional, Karthikeyan, Vilvapathy Senguttuvan, additional, Saleh, Ramadan, additional, Russo, Giorgio Ivan, additional, Pinggera, Germar-Michael, additional, Chung, Eric, additional, Savira, Missy, additional, Colpi, Giovanni M., additional, Zohdy, Wael, additional, Pescatori, Edoardo, additional, Park, Hyun Jun, additional, Fukuhara, Shinichiro, additional, Tsujimura, Akira, additional, Rojas-Cruz, Cesar, additional, Marino, Angelo, additional, Mak, Siu King, additional, Amar, Edouard, additional, Ibrahim, Wael, additional, Sindhwani, Puneet, additional, Alhathal, Naif, additional, Busetto, Gian Maria, additional, Hashimi, Manaf Al, additional, El-Sakka, Ahmed, additional, Ramazan, Asci, additional, Dimitriadis, Fotios, additional, Timpano, Massimiliano, additional, Jezek, Davor, additional, Altay, Baris, additional, Zylbersztejn, Daniel Suslik, additional, Wong, Michael YC, additional, Moon, Du Geon, additional, Wyns, Christine, additional, Gamidov, Safar, additional, Akhavizadegan, Hamed, additional, Franceschelli, Alessandro, additional, Aydos, Kaan, additional, Quang, Vinh Nguyen, additional, Ashour, Shedeed, additional, Dayel, Adel Al, additional, Al-Marhoon, Mohamed S., additional, Micic, Sava, additional, Binsaleh, Saleh, additional, Hussein, Alayman, additional, Elbardisi, Haitham, additional, Mostafa, Taymour, additional, Taha, Emad, additional, Ramsay, Jonathan, additional, Zachariou, Athanasios, additional, Abdelrahman, Islam Fathy Soliman, additional, Rajmil, Osvaldo, additional, Kalkanli, Arif, additional, Molina, Juan Manuel Corral, additional, Bocu, Kadir, additional, Duarsa, Gede Wirya Kusuma, additional, Ceker, Gokhan, additional, Serefoglu, Ege Can, additional, Bahar, Fahmi, additional, Gherabi, Nazim, additional, Kuroda, Shinnosuke, additional, Bouzouita, Abderrazak, additional, Gudeloglu, Ahmet, additional, Ceyhan, Erman, additional, Hasan, Mohamed Saeed Mohamed, additional, Musa, Muhammad Ujudud, additional, Motawi, Ahmad, additional, Chak-Lam, Cho, additional, Taniguchi, Hisanori, additional, Ho, Christopher Chee Kong, additional, Vazquez, Jesus Fernando Solorzano, additional, Mutambirwa, Shingai, additional, Gungor, Nur Dokuzeylul, additional, Bendayan, Marion, additional, Giulioni, Carlo, additional, Baser, Aykut, additional, Falcone, Marco, additional, Boeri, Luca, additional, Blecher, Gideon, additional, Kheradmand, Alireza, additional, Sethupathy, Tamilselvi, additional, Adriansjah, Ricky, additional, Narimani, Nima, additional, Konstantinidis, Charalampos, additional, Nguyen, Tuan Thanh, additional, Japari, Andrian, additional, Dolati, Parisa, additional, Singh, Keerti, additional, Ozer, Cevahir, additional, Sarikaya, Selcuk, additional, Sheibak, Nadia, additional, Bosco, Ndagijimana Jean, additional, Özkent, Mehmet Serkan, additional, Le, Sang Thanh, additional, Sokolakis, Ioannis, additional, Katz, Darren, additional, Smith, Ryan, additional, Truong, Manh Nguyen, additional, Le, Tan V., additional, Huang, Zhongwei, additional, Deger, Muslim Dogan, additional, Arslan, Umut, additional, Calik, Gokhan, additional, Franco, Giorgio, additional, Rashed, Ayman, additional, Kahraman, Oguzhan, additional, Andreadakis, Sotiris, additional, Putra, Rosadi, additional, Balercia, Giancarlo, additional, Khalafalla, Kareim, additional, Cannarella, Rossella, additional, Tuấn, Anh Đặng, additional, Meliegy, Amr El, additional, Zilaitiene, Birute, additional, Ramirez, Marlene Lizbeth Zamora, additional, Giacone, Filippo, additional, Calogero, Aldo E., additional, Makarounis, Konstantinos, additional, Jindal, Sunil, additional, Hoai, Bac Nguyen, additional, Banthia, Ravi, additional, Peña, Marcelo Rodriguez, additional, Moorthy, Dharani, additional, Adamyan, Aram, additional, Kulaksiz, Deniz, additional, Kandil, Hussein, additional, Sofikitis, Nikolaos, additional, Salzano, Ciro, additional, Jungwirth, Andreas, additional, Banka, Surendra Reddy, additional, Mierzwa, Tiago Cesar, additional, Turunç, Tahsin, additional, Jain, Divyanu, additional, Avoyan, Armen, additional, Salacone, Pietro, additional, Kadıoğlu, Ateş, additional, Gupta, Chirag, additional, Lin, Haocheng, additional, Shamohammadi, Iman, additional, Mogharabian, Nasser, additional, Barrett, Trenton, additional, Danacıoğlu, Yavuz Onur, additional, Crafa, Andrea, additional, Daoud, Salima, additional, Malhotra, Vineet, additional, Almardawi, Abdulmalik, additional, Selim, Osama Mohamed, additional, Moussa, Mohamad, additional, Haghdani, Saeid, additional, Duran, Mesut Berkan, additional, Kunz, Yannic, additional, Preto, Mirko, additional, Eugeni, Elena, additional, Nguyen, Thang, additional, Elshahid, Ahmed Rashad, additional, Suyono, Seso Sulijaya, additional, Parikesit, Dyandra, additional, Nada, Essam, additional, Orozco, Eduardo Gutiérrez, additional, Boitrelle, Florence, additional, Trang, Nguyen Thi Minh, additional, Jamali, Mounir, additional, Nair, Raju, additional, Ruzaev, Mikhail, additional, Gadda, Franco, additional, Thomas, Charalampos, additional, Ferreira, Raphael Henrique, additional, Gul, Umit, additional, Maruccia, Serena, additional, Kanbur, Ajay, additional, Kinzikeeva, Ella, additional, Abumelha, Saad, additional, Quang, Nguyen, additional, Kosgi, Raghavender, additional, Gokalp, Fatih, additional, Soebadi, Mohammad Ayodhia, additional, Paul, Gustavo Marquesine, additional, Sajadi, Hesamoddin, additional, Gupte, Deepak, additional, Ambar, Rafael F., additional, Sogutdelen, Emrullah, additional, Singla, Karun, additional, Basurkano, Ari, additional, Kim, Shannon Hee Kyung, additional, Gilani, Mohammad Ali Sadighi, additional, Nagao, Koichi, additional, Brodjonegoro, Sakti Ronggowardhana, additional, Rezano, Andri, additional, Elkhouly, Mohamed, additional, Mazzilli, Rossella, additional, Farsi, Hasan M. A., additional, Ba, Hung Nguyen, additional, Alali, Hamed, additional, Kafetzis, Dimitrios, additional, Long, Tran Quang Tien, additional, Alsaid, Sami, additional, Cuong, Hoang Bao Ngoc, additional, Oleksandr, Knigavko, additional, Mustafa, Akhmad, additional, Acosta, Herik, additional, Pai, Hrishikesh, additional, Şahin, Bahadır, additional, Arianto, Eko, additional, Teo, Colin, additional, Jayaprakash, Sanjay Prakash, additional, Rachman, Rinaldo Indra, additional, Yenice, Mustafa Gurkan, additional, Sefrioui, Omar, additional, Paghdar, Smit, additional, Priyadarshi, Shivam, additional, Tanic, Marko, additional, Alfatlawy, Noor Kareem, additional, Rizaldi, Fikri, additional, Vishwakarma, Ranjit B., additional, Kanakis, George, additional, Cherian, Dinesh Thomas, additional, Lee, Joe, additional, Galstyan, Raisa, additional, Keskin, Hakan, additional, Wurzacher, Jana, additional, Seno, Doddy Hami, additional, Noegroho, Bambang S., additional, Margiana, Ria, additional, Javed, Qaisar, additional, Castiglioni, Fabrizio, additional, Tanwar, Raman, additional, Puigvert, Ana, additional, Kaya, Coşkun, additional, Purnomo, Medianto, additional, Yazbeck, Chadi, additional, Amir, Azwar, additional, Borges, Edson, additional, Bellavia, Marina, additional, Deswanto, Isaac Ardianson, additional, V, Vinod K, additional, Liguori, Giovanni, additional, Minh, Dang Hoang, additional, Siddiqi, Kashif, additional, Colombo, Fulvio, additional, Zini, Armand, additional, Patel, Niket, additional, Çayan, Selahittin, additional, Al-Kawaz, Ula, additional, Ragab, Maged, additional, Hebrard, Guadalupe Hernández, additional, Hoffmann, Ivan, additional, Efesoy, Ozan, additional, Saylam, Barış, additional, and Agarwal, Ashok, additional

Published
2024
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20. Bioengineered dermal matrix (Integra®) reduces donor site morbidity in total phallic construction with radial artery forearm free-flap

Author

Falcone, Marco, primary, Preto, Mirko, additional, Ciclamini, Davide, additional, Peretti, Federica, additional, Scarabosio, Anna, additional, Blecher, Gideon, additional, Cirigliano, Lorenzo, additional, Ferro, Ilaria, additional, Plamadeala, Natalia, additional, Scavone, Martina, additional, Timpano, Massimiliano, additional, and Gontero, Paolo, additional

Published
2023
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21. Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study

Author

Cocci, Andrea, Ralph, David, Djinovic, Rados, Hatzichristodoulou, Georgios, Morelli, Girolamo, Salonia, Andrea, Capogrosso, Paolo, Romano, Andrea, Cito, Gianmartin, Di Maida, Fabrizio, Fernández-Pascual, Esaú, Romero-Otero, Javier, Egydio, Paulo, Falcone, Marco, Preto, Mirko, Chiriacò, Giovanni, Beck, Jack, Albersen, Maarten, Minhas, Suks, Cacciamani, Giovanni, Salamanca, Juan Ignacio Martinez, Mondani, Nicola, Minervini, Andrea, and Russo, Giorgio Ivan

Published
2021
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24. List of Contributors

Author

Albersen, M., primary, Beck, Jack, additional, Bianchi, Nicola, additional, Cakir, Omer Onur, additional, Capogrosso, P., additional, Chiriaco, G., additional, Cocci, Andrea, additional, Corona, Giovanni, additional, Dicuio, Mauro, additional, Edoardo, Pozzi, additional, Fabio, Castiglione, additional, Falcone, Marco, additional, Fernández-Pascual, Esaú, additional, Gontero, Paolo, additional, González-García, Javier, additional, Gul, Murat, additional, Hatzichristodoulou, Georgios, additional, Henrique Egydio, Paulo, additional, Johnson, M., additional, Jun Park, Hyun, additional, Krishnpappa, Pramod, additional, Levine, Laurence, additional, Maggi, Mario, additional, Martínez-Salamanca, Juan Ignacio, additional, Mauro, Marina di, additional, Milenkovic, U., additional, Nicolai, Melianthe, additional, Polloni, Gaia, additional, Pozzi, E., additional, Preto, Mirko, additional, Prontera, Olga, additional, Quintana, Luis Miguel, additional, Ralph, D.J., additional, Russo, Giorgio Ivan, additional, Salonia, A., additional, Scrimgeour, G., additional, Serefoglu, Ege Can, additional, Sforza, Alessandra, additional, Sokolakis, Ioannis, additional, Venturino, L., additional, and Ziegelmann, Matthew, additional

Published
2020
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27. Clinical Outcomes of Perioperative Chemotherapy in Patients With Locally Advanced Penile Squamous-Cell Carcinoma: Results of a Multicenter Analysis

Author

Necchi, Andrea, Pond, Gregory R., Raggi, Daniele, Ottenhof, Sarah R., Djajadiningrat, Rosa S., Horenblas, Simon, Khoo, Vincent, Hakenberg, Oliver W., Draeger, Desiree, Protzel, Chris, Heidenreich, Axel, Haidl, Friederike, Eigl, Bernie J., Nappi, Lucia, Matsumoto, Kazumasa, Vaishampayan, Ulka, Woods, Michael E., Salvioni, Roberto, Nicolai, Nicola, Catanzaro, Mario, Giannatempo, Patrizia, Geynisman, Daniel M., Preto, Mirko, Xylinas, Evanguelos, Milowsky, Matthew I., De Placido, Sabino, Di Lorenzo, Giuseppe, and Sonpavde, Guru

Published
2017
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30. Functional outcomes of organ sparing surgery for penile cancer confined to glans and premalignant lesions

Author

Falcone, Marco, Preto, Mirko, Gül, Murat, Şahin, Ali, Scavone, Martina, Cirigliano, Lorenzo, Peretti, Federica, Ferro, Ilaria, Plamadeala, Natalia, and Gontero, Paolo

Abstract

The first-line treatment of penile cancer confined to the glans (Tis-T2) is based on organ-sparing approaches. Our aim is to report functional outcomes of total glans resurfacing (TGR), wide local excision (WLE) and glansectomy. A retrospective analysis was conducted from January 2013 to October 2022. Ninety-nine patients were enrolled (22 TGR, 29 WLE, and 48 glansectomy). Sexual and urinary outcomes were explored using ad hoc and validated questionnaires (IIEF-15 and IPSS). The mean follow-up was 25.28 ± 24.87 months [95% CI: 20.38; 30.18]. 44 patients (12 TGR, 10 WLE, and 22 glansectomy) were assessed for functional outcomes. Overall, 86.36% of patients were satisfied with the surgery. The mean IIEF-15 score pre-operation was 54.91 ± 21.38 [95% CI: 48.41–61.41], and at 12 months post-operation, it was 44.39 ± 23.01 [95% CI: 37.39–51.39], with the change being statistically significant (mean difference: –10.52, (–19.15), p< 0.001). During the 0–12-month interval, IIEF-15 scores decreased across all techniques. Glansectomy and WLE showed significant decreases (Glansectomy: –12.955, –24.14%, [95% CI: –21.52, –4.38], p= 0.002; WLE: –14.1, –22.92%, [95% CI: –26.8, –1.39], p= 0.025 respectively), whereas TGR experienced a non-significant decrease (–3.083, –5.97%, CI: [–14.68, 8.51], p= 1.0). Concerning urinary function, only 18.18% of overall patients reported a negative impact of surgery. At 12-months, patients returned almost to pre-intervention IPSS values. Organ-sparing surgery guarantees a decent preservation of both erectile and voiding functions. TGR seems to provide better sexual outcomes when compared to other organ sparing approaches.

Published
2024
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31. Unveiling the molecular Hallmarks of Peyronie’s disease: a comprehensive narrative review

Author

Şahin, Ali, Babayev, Huseyn, Cirigliano, Lorenzo, Preto, Mirko, Falcone, Marco, Altıntas, Emre, and Gül, Murat

Abstract

Peyronie’s disease, a fibroinflammatory disorder, detrimentally impacts the sexual well-being of men and their partners. The manifestation of fibrotic plaques within penile tissue, attributed to dysregulated fibrogenesis, is pathognomonic for this condition. The onset of fibrosis hinges on the perturbation of the equilibrium between matrix metalloproteinases (MMPs), crucial enzymes governing the extracellular matrix, and tissue inhibitors of MMPs (TIMPs). In the context of Peyronie’s disease, there is an elevation in TIMP levels coupled with a decline in MMP levels, culminating in fibrogenesis. Despite the scant molecular insights into fibrotic pathologies, particularly in the context of Peyronie’s disease, a comprehensive literature search spanning 1995 to 2023, utilizing PubMed Library, was conducted to elucidate these mechanisms. The findings underscore the involvement of growth factors such as FGF and PDGF, and cytokines like IL-1 and IL-6, alongside PAI-1, PTX-3, HIF, and IgG4 in the fibrotic cascade. Given the tissue-specific modulation of fibrosis, comprehending the molecular underpinnings of penile fibrosis becomes imperative for the innovation of novel and efficacious therapies targeting Peyronie’s disease. This review stands as a valuable resource for researchers and clinicians engaged in investigating the molecular basis of fibrotic diseases, offering guidance for advancements in understanding Peyronie’s disease.

Published
2024
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32. Bioengineered dermal matrix (Integra®) reduces donor site morbidity in total phallic construction with radial artery forearm free-flap

Author

Falcone, Marco, Preto, Mirko, Ciclamini, Davide, Peretti, Federica, Scarabosio, Anna, Blecher, Gideon, Cirigliano, Lorenzo, Ferro, Ilaria, Plamadeala, Natalia, Scavone, Martina, Timpano, Massimiliano, and Gontero, Paolo

Abstract

Total phallic construction with radial artery forearm free-flap (RAFFF) is widely regarded as the gold standard approach for phalloplasty. However, donor-site morbidity remains a significant concern, which is typically managed by using a full-thickness skin graft (FTSG) on the forearm. Split thickness skin grafts (STSG) have been proposed as an alternative, along with the use of an acellular dermal matrix substitute. A retrospective comparative analysis was performed to assess the differences in operative, functional and cosmetic outcomes between FTSG (Group A) and the combination of acellular dermal matrix with STSG (Group B). A retrospective cohort study was conducted on all patients who underwent total phallic construction with RAFFF, between 2016 and 2021. Post-operative surgical and functional outcomes were evaluated using validated tools. A total of 34 patients were included in the study, with 18 patients (52.9%) in Group A and 16 patients (47.1%) in Group B. Group B demonstrated a significant advantage in terms of healing time (24 days vs. 30 days, p= 0.003) and complete graft take (93.8% vs. 27.8%, p= 0.001). Group B also had significantly shorter operative times (310 min vs. 447 min, p= 0.001) and a reduced median hospital stay (8 days vs. 10 days, p= 0.001). Satisfaction with cosmesis was significantly higher in Group B (93.8% vs. 66.7%, p= 0.048).

Published
2024
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37. The outcomes of penile prosthesis in neurologic patients: a multicentric retrospective series

Author

Falcone, Marco, primary, Capogrosso, Paolo, additional, Cirigliano, Lorenzo, additional, Geretto, Paolo, additional, Preto, Mirko, additional, Timpano, Massimiliano, additional, Ceruti, Carlo, additional, Peretti, Federica, additional, Ferro, Ilaria, additional, Plamadeala, Natalia, additional, Dehò, Federico, additional, Bettocchi, Carlo, additional, Manfredi, Celeste, additional, Spirito, Lorenzo, additional, Palmieri, Alessandro, additional, Manassero, Alberto, additional, Blecher, Gideon, additional, and Gontero, Paolo, additional

Published
2023
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41. Excision of pubic sarcome and complex genital reconstruction

Author

Preto, Mirko, primary, Falcone, Marco, additional, Ciclamini, Dr. Davide, additional, Lillaz, Dr. Beatrice, additional, Peretti, Dr. Federica, additional, Ferro, Dr. Ilaria, additional, Piana, Prof. Raimondo, additional, Sandrucci, Prof. Sergio, additional, and Gontero, Prof. Paolo, additional

Published
2022
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45. ESSM Position Statement on Surgical Treatment of Peyronie's Disease

Author

Osmonov, Daniar, primary, Ragheb, Ahmed, additional, Ward, Sam, additional, Blecher, Gideon, additional, Falcone, Marco, additional, Soave, Armin, additional, Dahlem, Roland, additional, van Renterghem, Koenraad, additional, Christopher, Nim, additional, Hatzichristodoulou, Georgios, additional, Preto, Mirko, additional, Garaffa, Giulio, additional, Albersen, Maarten, additional, Bettocchi, Carlo, additional, Corona, Giovanni, additional, and Reisman, Yacov, additional

Published
2021
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46. Outcomes and predictive factors of successful salvage microdissection testicular sperm extraction (mTESE) after failed classic TESE: results from a multicenter cross-sectional study

Author

Boeri, Luca, primary, Bebi, Carolina, additional, Dente, Donato, additional, Greco, Ermanno, additional, Turetti, Matteo, additional, Capece, Marco, additional, Cocci, Andrea, additional, Cito, Gianmartin, additional, Preto, Mirko, additional, Pescatori, Edoardo, additional, Ciampaglia, Walter, additional, Scroppo, Fabrizio Ildefonso, additional, Falcone, Marco, additional, Ceruti, Carlo, additional, Gadda, Franco, additional, Franco, Giorgio, additional, Dehò, Federico, additional, Palmieri, Alessandro, additional, Rolle, Luigi, additional, Gontero, Paolo, additional, Montorsi, Francesco, additional, Montanari, Emanuele, additional, and Salonia, Andrea, additional

Published
2021
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47. A prospective multicentric international study on the surgical outcomes and patients’ satisfaction rates of the ‘sliding’ technique for end-stage Peyronieʼs disease with severe shortening of the penis and erectile dysfunction

Author

Rolle, Luigi, Falcone, Marco, Ceruti, Carlo, Timpano, Massimiliano, Sedigh, Omid, Ralph, David J., Kuehhas, Franklin, Oderda, Marco, Preto, Mirko, Sibona, Mattia, Gillo, Arianna, Garaffa, Giulio, Gontero, Paolo, and Frea, Bruno

Published
2016
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48. THE IMPACT OF CIGARETTE SMOKING AND SMOKING CESSATION ON ONCOLOGICAL AGGRESSIVENESS AT RADICAL CYSTECTOMY – A PROSPECTIVE, EUROPEAN, MULTICENTER STUDY OF THE EAU YOUNG ACADEMIC UROLOGISTS (YAU) BLADDER CANCER WORKING GROUP: PD27-06

Author

Gild, Philipp, Schmid, Marianne, Cumberbatch, Marcus, Dobruch, Jakub, Gontero, Paolo, Mertens, Laura S., Necchi, Andrea, Noon, Aidan, Preto, Mirko, van Rhijn, Bas W.G., Roupret, Morgan, Seiler, Roland, Seisen, Thomas, Shariat, Shahrokh F., Aziz, Atiqullah, Chun, Felix K., Xylinas, Evanguelos, and Rink, Michael

Published
2016
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49. Risk of unfavorable outcomes after penile prosthesis implantation – results from a national registry (INSIST-ED)

Author

Preto, Mirko, Falcone, Marco, Plamadeala, Natalia, Schifano, Nicolò, Bettocchi, Carlo, Colombo, Fulvio, Fiordelise, Stefano, Vitarelli, Antonio, Silvani, Mauro, Mondaini, Nicola, Paradiso, Matteo, Ceruti, Carlo, Varvello, Francesco, Palumbo, Fabrizio, Avolio, Antonio, Antonini, Gabriele, Corvasce, Antonio, Pozza, Diego, Franco, Giorgio, Bitelli, Marco, Boezio, Francesco, Conti, Enrico, Caraceni, Enrico, Negro, Carlo, Carrino, Maurizio, Vicini, Patrizio, Ghidini, Nicola, Alei, Giovanni, Italiano, Emilio, Timpano, Massimiliano, Polito, Massimo, Natali, Alessandro, Tamai, Aldo, Pescatori, Edoardo, Dehò, Federico, Gideon, Blecher, Gontero, Paolo, Palmieri, Alessandro, and Capogrosso, Paolo

Abstract

Like all surgeries, penile prosthesis implantation (PPI) has the potential for both postoperative complications and suboptimal patient satisfaction. In order to assess risk factors for poor satisfaction, we reviewed patients who had been prospectively recruited in a national multi-institutional registry of penile prostheses procedures (INSIST-ED) from 2014 to 20121. Patient baseline characteristics and postoperative complications were recorded. The primary endpoint of this study was unfavorable outcomes after inflatable PPI, defined as significant postoperative complications (Clavien–Dindo ≥2) and/or Sexuality with Quality of Life and Sexuality with Penile Prosthesis (QoLSPP) scores below the 10th percentile. A total of 256 patients were included in the study. The median age was 60 years (IQR 56–67). The most common cause of erectile dysfunction (ED) was organic (42.2%), followed by pelvic surgery/radiotherapy (39.8%) and Peyronie’s disease (18.0%). Postoperative complications were recorded in 9.6%. High-grade complications (Clavien ≥2) occurred in 4.7%. At 1-year follow-up, the median QoLSPP total score was 71 (IQR 65–76). In all, 14.8% of patients were classified as having experienced unfavorable outcomes because of significant postoperative complications and/or QoLSPP scores below the 10th percentile. Logistic regression analysis demonstrated patient age to be non-linearly associated with the risk of experiencing unfavorable outcomes. A U-shaped correlation showed a lower risk for younger and older patients and a higher risk for middle-aged men. ED etiology and surgical volume were not associated with PPI outcomes. Physicians should, therefore, be aware that middle-aged men may be at higher risk of being unsatisfied following PPI compared to both younger and older patients.

Published
2023
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