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1. Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Author

Xu, Xiaoguang, Khunsriraksakul, Chachrit, Eales, James M., Rubin, Sebastien, Scannali, David, Saluja, Sushant, Talavera, David, Markus, Havell, Wang, Lida, Drzal, Maciej, Maan, Akhlaq, Lay, Abigail C., Prestes, Priscilla R., Regan, Jeniece, Diwadkar, Avantika R., Denniff, Matthew, Rempega, Grzegorz, Ryszawy, Jakub, Król, Robert, Dormer, John P., Szulinska, Monika, Walczak, Marta, Antczak, Andrzej, Matías-García, Pamela R., Waldenberger, Melanie, Woolf, Adrian S., Keavney, Bernard, Zukowska-Szczechowska, Ewa, Wystrychowski, Wojciech, Zywiec, Joanna, Bogdanski, Pawel, Danser, A. H. Jan, Samani, Nilesh J., Guzik, Tomasz J., Morris, Andrew P., Liu, Dajiang J., Charchar, Fadi J., and Tomaszewski, Maciej

Published
2024
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2. Lifestyle management of hypertension : International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Author

Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, Tomaszewski, Maciej, Charchar, Fadi J., Prestes, Priscilla R., Mills, Charlotte, Ching, Siew Mooi, Neupane, Dinesh, Marques, Francine Z., Sharman, James E., Vogt, Liffert, Burrell, Louise M., Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin G., Wallen, Matthew P., Renna, Nicolás F, Islam, Sheikh Mohammed Shariful, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta E., Klein, Britt, Borghi, Claudio, Browning, Colette J., Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Brunström, Mattias, Campbell, Norm R. C., Akinnibossun, Olutope Arinola, Veerabhadrappa, Praveen, Wainford, Richard D., Kruger, Ruan, Thomas, Shane A., Komori, Takahiro, Ralapanawa, Udaya, Cornelissen, Véronique A., Kapil, Vikas, Li, Yan, Zhang, Yuqing, Jafar, Tazeen H., Khan, Nadia, Williams, Bryan, Stergiou, George, and Tomaszewski, Maciej

Abstract

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools.

Published
2024
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3. Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney

Author

Eales, James M., Jiang, Xiao, Xu, Xiaoguang, Saluja, Sushant, Akbarov, Artur, Cano-Gamez, Eddie, McNulty, Michelle T., Finan, Christopher, Guo, Hui, Wystrychowski, Wojciech, Szulinska, Monika, Thomas, Huw B., Pramanik, Sanjeev, Chopade, Sandesh, Prestes, Priscilla R., Wise, Ingrid, Evangelou, Evangelos, Salehi, Mahan, Shakanti, Yusif, Ekholm, Mikael, Denniff, Matthew, Nazgiewicz, Alicja, Eichinger, Felix, Godfrey, Bradley, Antczak, Andrzej, Glyda, Maciej, Król, Robert, Eyre, Stephen, Brown, Jason, Berzuini, Carlo, Bowes, John, Caulfield, Mark, Zukowska-Szczechowska, Ewa, Zywiec, Joanna, Bogdanski, Pawel, Kretzler, Matthias, Woolf, Adrian S., Talavera, David, Keavney, Bernard, Maffia, Pasquale, Guzik, Tomasz J., O’Keefe, Raymond T., Trynka, Gosia, Samani, Nilesh J., Hingorani, Aroon, Sampson, Matthew G., Morris, Andrew P., Charchar, Fadi J., and Tomaszewski, Maciej

Published
2021
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5. Four-week inhibition of the renin–angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks.

Author

Byars, Sean G, Prestes, Priscilla R, Suphapimol, Varaporn, Takeuchi, Fumihiko, Vries, Nathan De, Maier, Michelle C, Melo, Mariana, Balding, David, Samani, Nilesh, Allen, Andrew M, Kato, Norihiro, Wilkinson-Berka, Jennifer L, Charchar, Fadi, and Harrap, Stephen B

Subjects
*GENE expression, *GENE regulatory networks, *LOSARTAN, *RENIN-angiotensin system, *ANGIOTENSIN-receptor blockers, *RENIN, *ACE inhibitors, *ONTOGENY, *EPIGENOMICS
Abstract

Aims Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin–angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously hypertensive rat (SHR). The kidney is involved in this fascinating phenomenon, but relevant changes in gene expression are unknown. Methods and results In SHR, we studied the effect of treatment between 10 and 14 weeks of age with the angiotensin receptor blocker, losartan, or the angiotensin-converting enzyme inhibitor, perindopril [with controls for non-specific effects of lowering blood pressure (BP)], on differential RNA expression, DNA methylation, and renin immunolabelling in the kidney at 20 weeks of age. RNA sequencing revealed a six-fold increase in renin gene (Ren) expression during losartan treatment (P < 0.0001). Six weeks after losartan, arterial pressure remained lower (P = 0.006), yet kidney Ren showed reduced expression by 23% after losartan (P = 0.03) and by 43% after perindopril (P = 1.4 × 10−6) associated with increased DNA methylation (P = 0.04). Immunolabelling confirmed reduced cortical renin after earlier RAS blockade (P = 0.002). RNA sequencing identified differential expression of mRNAs, miRNAs, and lncRNAs with evidence of networking and co-regulation. These included 13 candidate genes (Grhl1 , Ammecr1l , Hs6st1 , Nfil3 , Fam221a , Lmo4 , Adamts1 , Cish , Hif3a , Bcl6 , Rad54l2 , Adap1 , Dok4), the miRNA miR-145-3p, and the lncRNA AC115371. Gene ontogeny analyses revealed that these networks were enriched with genes relevant to BP, RAS, and the kidneys. Conclusion Early RAS inhibition in SHR resets genetic pathways and networks resulting in a legacy of reduced Ren expression and BP persisting for a minimum of 6 weeks. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Author

Charchar, Fadi J., primary, Prestes, Priscilla R., additional, Mills, Charlotte, additional, Ching, Siew Mooi, additional, Neupane, Dinesh, additional, Marques, Francine Z., additional, Sharman, James E., additional, Vogt, Liffert, additional, Burrell, Louise M., additional, Korostovtseva, Lyudmila, additional, Zec, Manja, additional, Patil, Mansi, additional, Schultz, Martin G., additional, Wallen, Matthew P., additional, Renna, Nicolás F., additional, Islam, Sheikh Mohammed Shariful, additional, Hiremath, Swapnil, additional, Gyeltshen, Tshewang, additional, Chia, Yook-Chin, additional, Gupta, Abhinav, additional, Schutte, Aletta E., additional, Klein, Britt, additional, Borghi, Claudio, additional, Browning, Colette J., additional, Czesnikiewicz-Guzik, Marta, additional, Lee, Hae-Young, additional, Itoh, Hiroshi, additional, Miura, Katsuyuki, additional, Brunström, Mattias, additional, Campbell, Norm R.C., additional, Akinnibossun, Olutope Arinola, additional, Veerabhadrappa, Praveen, additional, Wainford, Richard D., additional, Kruger, Ruan, additional, Thomas, Shane A., additional, Komori, Takahiro, additional, Ralapanawa, Udaya, additional, Cornelissen, Véronique A., additional, Kapil, Vikas, additional, Li, Yan, additional, Zhang, Yuqing, additional, Jafar, Tazeen H., additional, Khan, Nadia, additional, Williams, Bryan, additional, Stergiou, George, additional, and Tomaszewski, Maciej, additional

Published
2023
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7. Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis

Author

Eales, James M., Maan, Akhlaq A., Xu, Xiaoguang, Michoel, Tom, Hallast, Pille, Batini, Chiara, Zadik, Daniel, Prestes, Priscilla R., Molina, Elsa, Denniff, Matthew, Schroeder, Juliane, Bjorkegren, Johan L.M., Thompson, John, Maffia, Pasquale, Guzik, Tomasz J., Keavney, Bernard, Jobling, Mark A., Samani, Nilesh J., Charchar, Fadi J., and Tomaszewski, Maciej

Published
2019
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8. Molecular insights into genome-wide association studies of chronic kidney disease-defining traits

Author

Xu, Xiaoguang, Eales, James M., Akbarov, Artur, Guo, Hui, Becker, Lorenz, Talavera, David, Ashraf, Fehzan, Nawaz, Jabran, Pramanik, Sanjeev, Bowes, John, Jiang, Xiao, Dormer, John, Denniff, Matthew, Antczak, Andrzej, Szulinska, Monika, Wise, Ingrid, Prestes, Priscilla R., Glyda, Maciej, Bogdanski, Pawel, Zukowska-Szczechowska, Ewa, Berzuini, Carlo, Woolf, Adrian S., Samani, Nilesh J., Charchar, Fadi J., and Tomaszewski, Maciej

Published
2018
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12. Best practice data life cycle approaches for the life sciences

Author

Griffin, Philippa C, Khadake, Jyoti, LeMay, Kate S, Lewis, Suzanna E, Orchard, Sandra, Pask, Andrew, Pope, Bernard, Roessner, Ute, Russell, Keith, Seemann, Torsten, Treloar, Andrew, Tyagi, Sonika, Christiansen, Jeffrey H, Dayalan, Saravanan, Gladman, Simon, Hangartner, Sandra B, Hayden, Helen L, Ho, William WH, Keeble-Gagnère, Gabriel, Korhonen, Pasi K, Neish, Peter, Prestes, Priscilla R, Richardson, Mark F, Watson-Haigh, Nathan S, Wyres, Kelly L, Young, Neil D, Schneider, Maria Victoria, Griffin, Philippa C, Khadake, Jyoti, LeMay, Kate S, Lewis, Suzanna E, Orchard, Sandra, Pask, Andrew, Pope, Bernard, Roessner, Ute, Russell, Keith, Seemann, Torsten, Treloar, Andrew, Tyagi, Sonika, Christiansen, Jeffrey H, Dayalan, Saravanan, Gladman, Simon, Hangartner, Sandra B, Hayden, Helen L, Ho, William WH, Keeble-Gagnère, Gabriel, Korhonen, Pasi K, Neish, Peter, Prestes, Priscilla R, Richardson, Mark F, Watson-Haigh, Nathan S, Wyres, Kelly L, Young, Neil D, and Schneider, Maria Victoria

Published
2018

13. Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Author

Marques, Francine Z., Prestes, Priscilla R, Kähönen, Mika, Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, and Tampere University

Subjects
GlycA, Biolääketieteet - Biomedicine, lipocalin-2, Sisätaudit - Internal medicine, systems biology, gene coexpression networks, NGAL, hypertrophy, concentric hypertrophy, C-reactive protein
Published
2017

14. Best practice data life cycle approaches for the life sciences

Author

Griffin, Philippa C., primary, Khadake, Jyoti, additional, LeMay, Kate S., additional, Lewis, Suzanna E., additional, Orchard, Sandra, additional, Pask, Andrew, additional, Pope, Bernard, additional, Roessner, Ute, additional, Russell, Keith, additional, Seemann, Torsten, additional, Treloar, Andrew, additional, Tyagi, Sonika, additional, Christiansen, Jeffrey H., additional, Dayalan, Saravanan, additional, Gladman, Simon, additional, Hangartner, Sandra B., additional, Hayden, Helen L., additional, Ho, William W.H., additional, Keeble-Gagnère, Gabriel, additional, Korhonen, Pasi K., additional, Neish, Peter, additional, Prestes, Priscilla R., additional, Richardson, Mark F., additional, Watson-Haigh, Nathan S., additional, Wyres, Kelly L., additional, Young, Neil D., additional, and Schneider, Maria Victoria, additional

Published
2018
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15. Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Author

University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Marques, Francine Z., Prestes, Priscilla R., Byars, Sean G., Ritchie, Scott C., Wurtz, Peter, Patel, Sheila K., Booth, Scott A., Rana, Indrajeetsinh, Minoda, Yosuke, Berzins, Stuart P., Curl, Claire L., Bell, James R., Wai, Bryan, Srivastava, Piyush M., Kangas, Antti J., Soininen, Pasi, Ruohonen, Saku, Kahonen, Mika, Lehtimaki, Terho, Raitoharju, Emma, Havulinna, Aki, Perola, Markus, Raitakari, Olli, Salomaa, Veikko, Ala-Korpela, Mika, Kettunen, Johannes, McGlynn, Maree, Kelly, Jason, Wlodek, Mary E., Lewandowski, Paul A., Delbridge, Lea M., Burrell, Louise M., Inouye, Michael, Harrap, Stephen B., Charchar, Fadi J., University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Marques, Francine Z., Prestes, Priscilla R., Byars, Sean G., Ritchie, Scott C., Wurtz, Peter, Patel, Sheila K., Booth, Scott A., Rana, Indrajeetsinh, Minoda, Yosuke, Berzins, Stuart P., Curl, Claire L., Bell, James R., Wai, Bryan, Srivastava, Piyush M., Kangas, Antti J., Soininen, Pasi, Ruohonen, Saku, Kahonen, Mika, Lehtimaki, Terho, Raitoharju, Emma, Havulinna, Aki, Perola, Markus, Raitakari, Olli, Salomaa, Veikko, Ala-Korpela, Mika, Kettunen, Johannes, McGlynn, Maree, Kelly, Jason, Wlodek, Mary E., Lewandowski, Paul A., Delbridge, Lea M., Burrell, Louise M., Inouye, Michael, Harrap, Stephen B., and Charchar, Fadi J.

Abstract

Background-Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular death. The neutrophil inflammatory protein, lipocalin-2 (LCN2/NGAL), is elevated in certain forms of cardiac hypertrophy and acute heart failure. However, a specific role for LCN2 in predisposition and etiology of hypertrophy and the relevant genetic determinants are unclear. Here, we defined the role of LCN2 in concentric cardiac hypertrophy in terms of pathophysiology, inflammatory expression networks, and genomic determinants. Methods and Results-We used 3 experimental models: a polygenic model of cardiac hypertrophy and heart failure, a model of intrauterine growth restriction and Lcn2-knockout mouse; cultured cardiomyocytes; and 2 human cohorts: 114 type 2 diabetes mellitus patients and 2064 healthy subjects of the YFS (Young Finns Study). In hypertrophic heart rats, cardiac and circulating Lcn2 was significantly overexpressed before, during, and after development of cardiac hypertrophy and heart failure. Lcn2 expression was increased in hypertrophic hearts in a model of intrauterine growth restriction, whereas Lcn2-knockout mice had smaller hearts. In cultured cardiomyocytes, Lcn2 activated molecular hypertrophic pathways and increased cell size, but reduced proliferation and cell numbers. Increased LCN2 was associated with cardiac hypertrophy and diastolic dysfunction in diabetes mellitus. In the YFS, LCN2 expression was associated with body mass index and cardiac mass and with levels of inflammatory markers. The single-nucleotide polymorphism, rs13297295, located near LCN2 defined a significant cis-eQTL for LCN2 expression. Conclusions-Direct effects of LCN2 on cardiomyocyte size and number and the consistent associations in experimental and human analyses reveal a central role for LCN2 in the ontogeny of cardiac hypertrophy and heart failure.

Published
2017

16. Experimental and Human Evidence for Lipocalin‐2 (Neutrophil Gelatinase‐Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and Heart Failure

Author

Marques, Francine Z., primary, Prestes, Priscilla R., additional, Byars, Sean G., additional, Ritchie, Scott C., additional, Würtz, Peter, additional, Patel, Sheila K., additional, Booth, Scott A., additional, Rana, Indrajeetsinh, additional, Minoda, Yosuke, additional, Berzins, Stuart P., additional, Curl, Claire L., additional, Bell, James R., additional, Wai, Bryan, additional, Srivastava, Piyush M., additional, Kangas, Antti J., additional, Soininen, Pasi, additional, Ruohonen, Saku, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Raitoharju, Emma, additional, Havulinna, Aki, additional, Perola, Markus, additional, Raitakari, Olli, additional, Salomaa, Veikko, additional, Ala‐Korpela, Mika, additional, Kettunen, Johannes, additional, McGlynn, Maree, additional, Kelly, Jason, additional, Wlodek, Mary E., additional, Lewandowski, Paul A., additional, Delbridge, Lea M., additional, Burrell, Louise M., additional, Inouye, Michael, additional, Harrap, Stephen B., additional, and Charchar, Fadi J., additional

Published
2017
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17. Best practice data life cycle approaches for the life sciences

Author

Griffin, Philippa C., primary, Khadake, Jyoti, additional, LeMay, Kate S., additional, Lewis, Suzanna E., additional, Orchard, Sandra, additional, Pask, Andrew, additional, Pope, Bernard, additional, Roessner, Ute, additional, Russell, Keith, additional, Seemann, Torsten, additional, Treloar, Andrew, additional, Tyagi, Sonika, additional, Christiansen, Jeffrey H., additional, Dayalan, Saravanan, additional, Gladman, Simon, additional, Hangartner, Sandra B., additional, Hayden, Helen L., additional, Ho, William W.H., additional, Keeble-Gagnère, Gabriel, additional, Korhonen, Pasi K., additional, Neish, Peter, additional, Prestes, Priscilla R., additional, Richardson, Mark F., additional, Watson-Haigh, Nathan S., additional, Wyres, Kelly L., additional, Young, Neil D., additional, and Schneider, Maria Victoria, additional

Published
2017
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25. Predicting biogeographical ancestry in admixed individuals – values and limitations of using uniparental and autosomal markers.

Author

Prestes, Priscilla R., Mitchell, R. John, Daniel, Runa, Sanchez, Juan J., and van Oorschot, Roland A.H.

Subjects
*BIOGEOGRAPHY, *GENEALOGY, *MICROSATELLITE repeats, *COSMOPOLITANISM, *MITOCHONDRIAL DNA, *SINGLE nucleotide polymorphisms
Abstract

When microsatellite profiles generated from crime scene samples do not match a known person, or eye-witness information is unreliable, highly informative uniparental and autosomal markers can help unveil biogeographical ancestry. However, as genetic admixture is becoming increasingly common in cosmopolitan societies, concern arises with their accuracy and suitability when dealing with samples from admixed individuals. Here we assess the ability to detect biogeographical ancestry in 85 individuals from self-declared Asian and European admixed families using a set of uniparental (Y and mitochondrial DNA) and autosomal single nucleotide polymorphisms, specifically selected to distinguish between these two biogeographical ancestries. Haplogroups and autosomal genotypes were investigated using STRUCTURE to detect levels of admixture. All haplogroups were characteristic of self-declared populations of origin. Overall, the autosomal markers inferred biogeographical ancestry more accurately in admixed individuals, showing no significant differences between observed and expected contribution from each population studied according to level of admixture, although some outliers were observed. We suggest a panel of highly informative autosomal and uniparental markers should be employed to infer biogeographical ancestry of an individual to help detect admixed ancestries. [ABSTRACT FROM PUBLISHER]

Published
2016
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26. Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension.

Author

Charchar FJ, Prestes PR, Mills C, Ching SM, Neupane D, Marques FZ, Sharman JE, Vogt L, Burrell LM, Korostovtseva L, Zec M, Patil M, Schultz MG, Wallen MP, Renna NF, Islam SMS, Hiremath S, Gyeltshen T, Chia YC, Gupta A, Schutte AE, Klein B, Borghi C, Browning CJ, Czesnikiewicz-Guzik M, Lee HY, Itoh H, Miura K, Brunström M, Campbell NRC, Akinnibossun OA, Veerabhadrappa P, Wainford RD, Kruger R, Thomas SA, Komori T, Ralapanawa U, Cornelissen VA, Kapil V, Li Y, Zhang Y, Jafar TH, Khan N, Williams B, Stergiou G, and Tomaszewski M

Subjects
Humans, Life Style, Blood Pressure, Hypertension prevention & control, Hypertension complications, Cardiovascular Diseases etiology, Heart Failure complications
Abstract

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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