195 results on '"Presicci, A"'
Search Results
2. The Use of Full-Contour Zirconia for Full-Arch Implant-Supported Rehabilitations—A Narrative Review
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De Angelis, N., De Lorenzi, M., Presicci, F., Yumang, C., Lazetera, A., and Pesce, P.
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- 2024
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3. Abstract 16061: Correlation Between Obesity and Ventricular Tachycardia in Individuals With HFrEF: Analysis From the DERIVATE Cohort
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Mosley, Jackson L, Voruganti, Dinesh, Sadaf, Murrium I, Mansour, Munthir, Spraggins, Robert, Abouelenein, Saly, Abete, Raffaele, Aquaro, Giovanni, Baggiano, Andrea, Barison, Andrea, Bogaert, Jan, Camastra, Giovanni, Carigi, Samuela, Carrabba, Nazario, Casavecchia, Grazia, Censi, Stefano, Cicala, Gloria, De Cecco, Carlo, De Lazzari, Manuel, Di Giovine, Gabriella, Calo, Leonardo, Dobrovie, Monica, Focardi, Marta, Fusini, Laura, Gaibazzi, Nicola, Gismondi, Annalaura, Gravina, Matteo, Guglielmo, Marco, Lanzillo, chiara, lombardi, massimo, Lorenzoni, Valentina, Lozano Torres, Jordi, Margonato, Davide, Martini, Chiara, Marzo, Francesca, Masci, Pier-Giorgio, Masi, Ambra, Moro, Claudio, Muscogiuri, Giuseppe, Mushtaq, Saima, Nese, Alberto, Palumbo, Alessandro, Pavon, Anna Giulia, Pedrotti, Patrizia, Perazzolo Marra, Martina, Praadella, Silvia, Presicci, Cristina, Pontone, Gianluca, and AlʼAref, Subhi J
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- 2023
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4. Abstract 14398: Predictors of Major Adverse Cardiac Events in Individuals With Left Bundle Branch Block and Cardiac Resynchronization Therapy: Analysis From the Derivate Registry
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Mueller, Joshua, Jensen, Hanna, Robinson, Samantha, Abete, Raffaele, Aquaro, Giovanni, Baggiano, Andrea, Barison, Andrea, Bogaert, Jan, Camastra, Giovanni, Carigi, Samuela, Carrabba, Nazario, Casavecchia, Grazia, Censi, Stefano, Cicala, Gloria, De Cecco, Carlo, De Lazzari, Manuel, Di Giovine, Gabriella, Calo, Leonardo, Dobrovie, Monica, Focardi, Marta, Fusini, Laura, Gaibazzi, Nicola, Gismondi, Annalaura, Gravina, Matteo, Guglielmo, Marco, Lanzillo, chiara, lombardi, massimo, Lorenzoni, Valentina, Lozano Torres, Jordi, Margonato, Davide, Martini, Chiara, Marzo, Francesca, Masci, Pier-Giorgio, Masi, Ambra, Moro, Claudio, Muscogiuri, Giuseppe, Mushtaq, Saima, Nese, Alberto, Palumbo, Alessandro, Pavon, Anna Giulia, Pedrotti, Patrizia, Perazzolo Marra, Martina, Pradella, Silvia, Presicci, Cristina, Rabbat, Mark, Raineri, Claudi, Rodriguez-Palomares, Jose, Pontone, Gianluca, and AlʼAref, Subhi J
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- 2023
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5. The Blue-RoSES Project: a Gate for Remote Exploration of the Seas
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Bibuli, Marco, Caccia, Massimo, Presicci, Claudia, Sebastiao, Luis, Cabecinhas, David, Potes, André, Quintas, João, Jacinto, Marcelo, and Pascoal, Antonio
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- 2023
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6. Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy: The DERIVATE–ICM International Registry
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Pontone, Gianluca, Guaricci, Andrea Igoren, Fusini, Laura, Baggiano, Andrea, Guglielmo, Marco, Muscogiuri, Giuseppe, Volpe, Alessandra, Abete, Raffaele, Aquaro, Giovanni, Barison, Andrea, Bogaert, Jan, Camastra, Giovanni, Carigi, Samuela, Carrabba, Nazario, Casavecchia, Grazia, Censi, Stefano, Cicala, Gloria, De Cecco, Carlo N., De Lazzari, Manuel, Di Giovine, Gabriella, Di Roma, Mauro, Dobrovie, Monica, Focardi, Marta, Gaibazzi, Nicola, Gismondi, Annalaura, Gravina, Matteo, Lanzillo, Chiara, Lombardi, Massimo, Lorenzoni, Valentina, Lozano-Torres, Jordi, Martini, Chiara, Marzo, Francesca, Masi, Ambra, Memeo, Riccardo, Moro, Claudio, Nese, Alberto, Palumbo, Alessandro, Pavon, Anna Giulia, Pedrotti, Patrizia, Marra, Martina Perazzolo, Pica, Silvia, Pradella, Silvia, Presicci, Cristina, Rabbat, Mark G., Raineri, Claudia, Rodriguez-Palomares, José F., Sbarbati, Stefano, Schoepf, U. Joseph, Squeri, Angelo, Sverzellati, Nicola, Symons, Rolf, Tat, Emily, Timpani, Mauro, Todiere, Giancarlo, Valentini, Adele, Varga-Szemes, Akos, Masci, Pier-Giorgio, and Schwitter, Juerg
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- 2023
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7. Associations of High-Sensitivity C-Reactive Protein and Interleukin-6 with Depression in a Sample of Italian Adolescents During COVID-19 Pandemic
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Serra M, Presicci A, Quaranta L, Achille M, Caputo E, Medicamento S, Margari F, Croce F, and Margari L
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endophenotype ,inflammation ,network ,self-hatred ,stress ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Maria Serra,1 Anna Presicci,2 Luigi Quaranta,3 Mariaclara Achille,4 Elvita Caputo,4 Silvia Medicamento,4 Francesco Margari,5 Federica Croce,5 Lucia Margari4 1Department of Pharmacy-Pharmaceutical Sciences, University of Bari “Aldo Moro”, Bari, Italy; 2Department of Neuroscience, Sense Organs and Locomotor System, University Hospital “Policlinico”, Bari, Italy; 3Department of Computer Science, University of Bari “Aldo Moro”, Bari, Italy; 4Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, Bari, Italy; 5Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari “Aldo Moro”, Bari, ItalyCorrespondence: Maria Serra, Department of Pharmacy-Pharmaceutical Sciences, University of Bari “Aldo Moro”, Via Edoardo Orabona 4, Bari, 70125, Italy, Tel +39 080 5592829, Fax +39 080 5595260, Email maria.serra.13@gmail.comIntroduction: Many studies highlighted the role of inflammation in the pathogenesis of depression, although not for every patient nor for every symptom. It is widely shared that stressors can increase inflammation and lead to depressive symptoms. Little is known about the symptom-specificity of the inflammation-depression link in adolescence, which we aimed to explore. The single symptom analysis is a core feature of the recent network approach to depression, supposing that psychiatric disorders consist of co-occurring symptoms and their tendency to cause each other.Patients and Methods: We recruited 52 adolescents diagnosed with a Depressive Disorder during the COVID-19 stressful period. We used regression analysis to measure associations between high sensitivity C-Reactive Protein (hs-CRP) and Interleukin-6 (IL-6) and depressive symptoms assessed by the Children’s Depression Inventory 2 (CDI 2). For the study of symptom specificity, we selected 13 items from the CDI 2 Self Report corresponding with the DSM-5 diagnostic criteria for Major Depressive Disorder and we coded them as dichotomous variables to perform a regression analysis.Results: We found that a higher CDI 2-Parent Version total score was significantly predicted by higher hs-CRP (coefficient 3.393; p 0.0128) and IL-6 (coefficient 3.128; p 0.0398). The endorsement of the symptom self-hatred, measuring the DSM-5 symptom “feelings of worthlessness”, was significantly predicted by hs-CRP (OR 10.97; 95% CI 1.29– 93.08; p 0.0282).Conclusion: A novel symptom-specificity emerged, with hs-CRP significantly predicting the endorsement of the symptom self-hatred, recognized as a core feature of adolescent depression, following the network theory. We considered it a possible phenotypic expression of one depression endophenotype previously causally linked to inflammation. Due to the limited sample size, these preliminary findings require confirmation with future research focusing on the relationship between inflammation and self-hatred and other central nodes of the depression network, representing an opportunity for targeting interventions on crucial symptoms.Keywords: endophenotype, inflammation, network, self-hatred, stress
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- 2022
8. Depressive risk among Italian socioeconomically disadvantaged children and adolescents during COVID-19 pandemic: a cross-sectional online survey
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Maria Serra, Anna Presicci, Luigi Quaranta, Maria Rosaria Erminia Urbano, Lucia Marzulli, Emilia Matera, Francesco Margari, and Lucia Margari
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COVID-19 ,Socioeconomic disadvantage ,Low-income ,Children ,Adolescents ,Depression ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Children and adolescents and low-income individuals are considered particularly vulnerable for mental health implications during the current COVID-19 pandemic. Depression is a frequent negative emotional response during an epidemic outbreak and is also prone importantly to environmental risk like stressors derived from income inequality. We aimed to assess depressive symptomatology in a sample of Italian low-income minors during the COVID-19 outbreak. We hypothesized that the stronger were the negative effects of the pandemic on socioeconomic conditions, the higher would have been the risk for showing depressive symptoms. Methods We performed a cross-sectional study during July 2020, at the end of the Italian first wave of COVID-19 pandemic. We recruited 109 Italian socioeconomically disadvantaged children and adolescents from 7 to 17 years. We used an online survey to collect socio-demographic and clinical data and information about pandemic-related stressors and to assess depressive symptoms with the Children’s Depression Inventory 2 (CDI 2), Parent Version (Emotional Problems subscale) and Self-Report Short Form. We performed logistic regression analysis to assess the association between depressive symptoms and potential risk factors for mental health. Results 22% and 14% of participants showed depressive symptoms at the CDI 2 Parent Version and Self-Report, respectively. Participants coming from families experiencing a lack of basic supplies during the pandemic (34.9%) were more expected to show depressive symptoms at CDI 2 Parent Version. Participants with a pre-existing neuropsychiatric diagnosis (26.6%) were more likely to exhibit depressive symptoms measured by CDI 2 Parent Version. Conclusions The results of our study showed that a group of Italian socioeconomically disadvantaged children and adolescents were more vulnerable to depressive symptoms if they suffered from a paucity of essential supplies during the pandemic or had pre-existing neurodevelopmental disorders. The promotion of educational and child-care programs and activities could be crucial in sustaining the prevention of mental distress in those frail subjects who particularly need support outside the family. Further studies are needed to detect effective preventive and therapeutic strategies to adopt promptly in the case of another pandemic wave.
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- 2022
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9. Depressive risk among Italian socioeconomically disadvantaged children and adolescents during COVID-19 pandemic: a cross-sectional online survey
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Serra, Maria, Presicci, Anna, Quaranta, Luigi, Urbano, Maria Rosaria Erminia, Marzulli, Lucia, Matera, Emilia, Margari, Francesco, and Margari, Lucia
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- 2022
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10. Abstract 10990: The Prognostic Significance of Right Ventricular Dilation Assessed by Cardiac Magnetic Resonance Imaging in Heart Failure With Reduced Ejection Fraction
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Malkawi, Abdallah, Altibi, Ahmed, Mansour, Munthir, Schwitter, Juerg, Guaricci, Andrea, Masci, Pier-Giorgio, De Cecco, Carlo, Carrabba, Nazario, Varga-Szemes, Akos, Masi, Ambra, Baggiano, Andrea, Barison, Andrea, lanzillo, chiara, Martini, Chiara, moro, claudia, Andreini, Daniele, Conte, Edoardo, Rabbat, Mark, Focardi, Marta, Perazzolo Marra, Martina, Lombardi, Massimo, Dobrovie, Monica, Gaibazzi, Nicola, PEDROTTI, PATRIZIA, Schoepf, Joseph, Mushtaq, Saima, Censi, Stefano, Tat, Emily, Bogaert, Jan, Lozano Torres, Jordi, Sverzellati, Nicola, Marco, Guglielmo, Gismondi, Annalaura, Gravina, Matteo, Presicci, Cristina, De Lazzari, Manuel, Palumbo, Alessandro, Valentini, Adele, Di Giovine, Gabriella, Fusini, Laura, Margonato, Davide, Timpani, Mauro, Nese, Alberto, Pepi, Mauro, Cicala, Gloria, Muscogiuri, Giuseppe, Lorenzoni, Valentina, Pontone, Gianluca, and AlʼAref, Subhi J
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- 2022
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11. Assessing Clinical Features of Adolescents Suffering from Depression Who Engage in Non-Suicidal Self-Injury
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Maria Serra, Anna Presicci, Luigi Quaranta, Elvita Caputo, Mariaclara Achille, Francesco Margari, Federica Croce, Lucia Marzulli, and Lucia Margari
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depression ,non-suicidal self-injury ,self-harm ,specifier ,adolescent ,emotional dysregulation ,Pediatrics ,RJ1-570 - Abstract
Depressive disorders (DDs) and non-suicidal self-injury (NSSI) are important juvenile mental health issues, showing alarming increasing rates. They frequently co-occur, mainly among adolescents, increasing the suicide risk. We aimed to compare the clinical features of two groups of adolescents with DDs, differed by their engagement or not in NSSI (“DD + NSSI” and “DD”). We hypothesized that NSSI would characterize particularly severe forms of DDs suitable for becoming specific phenotypes of adolescent depression. We enrolled 56 adolescents (11–17 years) diagnosed with a DD according to the DSM-5 criteria. They were assessed for NSSI endorsement (Ottawa Self-Injury Inventory), depressive symptoms (Children’s Depression Inventory 2), emotional dysregulation (Difficulties in Emotional Regulation Scale), and anxiety symptoms (Screen for Child Anxiety-Related Emotional Disorders). The two groups accounted for 31 (“DD + NSSI”) and 25 (“DD”) individuals. The “DD + NSSI” group had significantly higher suicidal ideation (p 0.0039), emotional dysregulation (p 0.0092), depressive symptoms (p 0.0138), and anxiety symptoms (p 0.0153) than the “DD” group. NSSI seemed to characterize more severe phenotypes of adolescent depression, applying for a potential role as a “specifier” of DDs, describing relevant information for their management. Further studies are needed to support this hypothesis and its potential opportunities for prevention and treatment.
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- 2022
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12. Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services
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Gerritsen, S. E., van Bodegom, L. S., Dieleman, G. C., Overbeek, M. M., Verhulst, F. C., Wolke, Dieter, Rizopoulos, D., Appleton, R., van Amelsvoort, T. A. M. J., Bodier Rethore, C., Bonnet-Brilhault, F., Charvin, I., Da Fonseca, D., Davidović, N., Dodig-Ćurković, K., Ferrari, A., Fiori, F., Franić, T., Gatherer, C., de Girolamo, G., Heaney, N., Hendrickx, G., Jardri, R., Kolozsvari, A., Lida-Pulik, H., Lievesley, K., Madan, J., Mastroianni, M., Maurice, V., McNicholas, F., Nacinovich, R., Parenti, A., Paul, M., Purper-Ouakil, D., Rivolta, L., de Roeck, V., Russet, F., Saam, M. C., Sagar-Ouriaghli, I., Santosh, P. J., Sartor, A., Schulze, U. M. E., Scocco, P., Signorini, G., Singh, S. P., Singh, J., Speranza, M., Stagi, P., Stagni, P., Street, C., Tah, P., Tanase, E., Tremmery, S., Tuffrey, A., Tuomainen, H., Walker, L., Wilson, A., Maras, A., Adams, Laura, Allibrio, Giovanni, Armando, Marco, Aslan, Sonja, Baccanelli, Nadia, Balaudo, Monica, Bergamo, Fabia, Bertani, Angelo, Berriman, Jo, Boon, Albert, Braamse, Karen, Breuninger, Ulrike, Buttiglione, Maura, Buttle, Sarah, Schandrin, Aurélie, Cammarano, Marco, Canaway, Alastair, Cantini, Fortunata, Cappellari, Cristiano, Carenini, Marta, Carrà, Giuseppe, Ferrari, Cecilia, Chianura, Krizia, Coleman, Philippa, Colonna, Annalisa, Conese, Patrizia, Costanzo, Raffaella, Daffern, Claire, Danckaerts, Marina, de Giacomo, Andrea, Ermans, Jean-Pierre, Farmer, Alan, Fegert, Jörg M., Ferrari, Sabrina, Galea, Giuliana, Gatta, Michela, Gheza, Elisa, Goglia, Giacomo, Grandetto, MariaRosa, Griffin, James, Levi, Flavia Micol, Humbertclaude, Véronique, Ingravallo, Nicola, Invernizzi, Roberta, Kelly, Caoimhe, Killilea, Meghan, Kirwan, James, Klockaerts, Catherine, Kovač, Vlatka, Liew, Ashley, Lippens, Christel, Macchi, Francesca, Manenti, Lidia, Margari, Francesco, Margari, Lucia, Martinelli, Paola, McFadden, Leighton, Menghini, Deny, Miller, Sarah, Monzani, Emiliano, Morini, Giorgia, Mutafov, Todor, O’Hara, Lesley, Negrinotti, Cristina, Nelis, Emmanuel, Neri, Francesca, Nikolova, Paulina, Nossa, Marzia, Cataldo, Maria Giulia, Noterdaeme, Michele, Operto, Francesca, Panaro, Vittoria, Pastore, Adriana, Pemmaraju, Vinuthna, Pepermans, Ann, Petruzzelli, Maria Giuseppina, Presicci, Anna, Prigent, Catherine, Rinaldi, Francesco, Riva, Erika, Roekens, Anne, Rogers, Ben, Ronzini, Pablo, Sakar, Vehbi, Salvetti, Selena, Martinelli, Ottaviano, Sandhu, Tanveer, Schepker, Renate, Siviero, Marco, Slowik, Michael, Smyth, Courtney, Conti, Patrizia, Spadone, Maria Antonietta, Starace, Fabrizio, Stoppa, Patrizia, Tansini, Lucia, Toselli, Cecilia, Trabucchi, Guido, Tubito, Maria, van Dam, Arno, van Gutschoven, Hanne, van West, Dirk, Vanni, Fabio, Vannicola, Chiara, Varuzza, Cristiana, Varvara, Pamela, Ventura, Patrizia, Vicari, Stefano, Vicini, Stefania, von Bentzel, Carolin, Wells, Philip, Williams, Beata, Zabarella, Marina, Zamboni, Anna, Zanetti, Edda, HASH(0x5651c9679ff8), RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Child and Adolescent Psychiatry / Psychology, Epidemiology, Clinical Child and Family Studies, LEARN! - Child rearing, APH - Mental Health, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier de Versailles André Mignot (CHV), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Lille, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, The MILESTONE project was funded by EU FP7 programme under grant number 602442. SPS is part-funded by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care West Midlands (NIHR CLAHRC WM), now recommissioned as NIHR Applied Research Collaboration West Midlands. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. PS is the co-inventor of the HealthTrackerTM and is the Chief Executive Officer and shareholder in HealthTracker Ltd. FF is a Chief Technical Officer and AK is the Chief Finance Officer employed by HealthTracker Ltd, respectively. FCV publishes the Dutch translations of ASEBA, from which he receives remuneration. AM was a speaker and advisor for Neurim, Shire, Infectopharm, and Lilly (all not related to transition research)., European Project: 602442,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,MILESTONE(2014), The Milestone Consortium, Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, and Zanetti, E
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Adult mental health service ,Adult ,Mental Health Services ,Parents ,Health (social science) ,Child and adolescent mental health service ,Social Psychology ,RJ ,Epidemiology ,ADOLESCENT ,Child and adolescent mental health services ,Adult mental health services ,Young adults ,Transition ,SDG 3 - Good Health and Well-being ,PEOPLE ,SCHIZOPHRENIA ,Humans ,Family ,Child ,Demography ,Mental Disorders ,CARE ,Psychiatry and Mental health ,Young adult ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,RA - Abstract
Purpose The service configuration with distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) may be a barrier to continuity of care. Because of a lack of transition policy, CAMHS clinicians have to decide whether and when a young person should transition to AMHS. This study describes which characteristics are associated with the clinicians’ advice to continue treatment at AMHS. Methods Demographic, family, clinical, treatment, and service-use characteristics of the MILESTONE cohort of 763 young people from 39 CAMHS in Europe were assessed using multi-informant and standardized assessment tools. Logistic mixed models were fitted to assess the relationship between these characteristics and clinicians’ transition recommendations. Results Young people with higher clinician-rated severity of psychopathology scores, with self- and parent-reported need for ongoing treatment, with lower everyday functional skills and without self-reported psychotic experiences were more likely to be recommended to continue treatment. Among those who had been recommended to continue treatment, young people who used psychotropic medication, who had been in CAMHS for more than a year, and for whom appropriate AMHS were available were more likely to be recommended to continue treatment at AMHS. Young people whose parents indicated a need for ongoing treatment were more likely to be recommended to stay in CAMHS. Conclusion Although the decision regarding continuity of treatment was mostly determined by a small set of clinical characteristics, the recommendation to continue treatment at AMHS was mostly affected by service-use related characteristics, such as the availability of appropriate services.
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- 2022
13. Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
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Anna Presicci, Maria Serra, Mariaclara Achille, Elvita Caputo, and Lucia Margari
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pediatric optic neuritis ,acquired demyelinating syndromes ,multiple sclerosis ,neuromyelitis optica ,ADEM-ON ,myelin oligodendrocyte glycoprotein ,Pediatrics ,RJ1-570 - Abstract
Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), such as multiple sclerosis (MS), neuromyelitis optica (NMO), or other syndromes related to the myelin oligodendrocyte glycoprotein IgG antibodies (MOG-IgG). These different PON phenotypes present variable clinical and radiological features, plasma and liquor biomarkers, and prognosis. We describe four pediatric cases presenting clinically with ON, with different etiopathogenetic pictures: one case had a probable infective etiology, while the others were associated with different demyelinating disorders (MS, NMO, syndrome related to MOG-IgG). We discuss the possible evolution of presenting ON in other ADSs, based on recent literature. A careful evaluation of the clinical and investigation findings and the natural course of PON is necessary to define its pathogenic pathway and evolution. Further prolonged follow-up studies are needed to highlight the predictors of PON evolution, its potential sequelae, and the best treatment options.
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- 2021
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14. Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy
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Gianluca Pontone, Andrea Igoren Guaricci, Laura Fusini, Andrea Baggiano, Marco Guglielmo, Giuseppe Muscogiuri, Alessandra Volpe, Raffaele Abete, Giovanni Aquaro, Andrea Barison, Jan Bogaert, Giovanni Camastra, Samuela Carigi, Nazario Carrabba, Grazia Casavecchia, Stefano Censi, Gloria Cicala, Carlo N. De Cecco, Manuel De Lazzari, Gabriella Di Giovine, Mauro Di Roma, Monica Dobrovie, Marta Focardi, Nicola Gaibazzi, Annalaura Gismondi, Matteo Gravina, Chiara Lanzillo, Massimo Lombardi, Valentina Lorenzoni, Jordi Lozano-Torres, Chiara Martini, Francesca Marzo, Ambra Masi, Riccardo Memeo, Claudio Moro, Alberto Nese, Alessandro Palumbo, Anna Giulia Pavon, Patrizia Pedrotti, Martina Perazzolo Marra, Silvia Pica, Silvia Pradella, Cristina Presicci, Mark G. Rabbat, Claudia Raineri, José F. Rodriguez-Palomares, Stefano Sbarbati, U. Joseph Schoepf, Angelo Squeri, Nicola Sverzellati, Rolf Symons, Emily Tat, Mauro Timpani, Giancarlo Todiere, Adele Valentini, Akos Varga-Szemes, Pier-Giorgio Masci, and Juerg Schwitter
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2023
15. Comparative US-MRI evaluation of the Insall–Salvati index
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Giovagnorio, Francesco, Olive, Matteo, Casinelli, Alice, Maggini, Elena, Presicci, Cristina, Tominaj, Celijeta, and Ricci, Paolo
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- 2017
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16. Infection Risk Evaluation Based on a Novel Scoring System in Chronic Lymphocytic Leukemia (CLL) Patients at Diagnosis
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Murru, Roberta, primary, Galitzia, Andrea, additional, Caocci, Giovanni, additional, Barabino, Luca, additional, Presicci, Roberta, additional, Culurgioni, Fabio, additional, Massidda, Stefania, additional, Oppi, Sara, additional, and La Nasa, Giorgio, additional
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- 2022
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17. Cohort profile
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Gerritsen, Suzanne E., Maras, Athanasios, van Bodegom, Larissa S., Overbeek, Mathilde M., Verhulst, Frank C., Wolke, Dieter, Appleton, Rebecca, Bertani, Angelo, Cataldo, Maria G., Conti, Patrizia, Da Fonseca, David, Davidović, Nikolina, Dodig-Ćurković, Katarina, Ferrari, Cecilia, Fiori, Federico, Franić, Tomislav, Gatherer, Charlotte, De Girolamo, Giovanni, Heaney, Natalie, Hendrickx, Gaëlle, Kolozsvari, Alfred, Levi, Flavia Micol, Lievesley, Kate, Madan, Jason, Martinelli, Ottaviano, Mastroianni, Mathilde, Maurice, Virginie, McNicholas, Fiona, O'Hara, Lesley, Paul, Moli, Purper-Ouakil, Diane, de Roeck, Veronique, Russet, Frédérick, Saam, Melanie C., Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Sartor, Anne, Schandrin, Aurélie, Schulze, Ulrike M. E., Signorini, Giulia, Singh, Swaran P., Singh, Jatinder, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuffrey, Amanda, Tuomainen, Helena, van Amelsvoort, Therese A. M. J., Wilson, Anna, Walker, Leanne, Dieleman, Gwen C., Adams, Laura, Allibrio, Giovanni, Armando, Marco, Aslan, Sonja, Baccanelli, Nadia, Balaudo, Monica, Bergamo, Fabia, Berriman, Jo, Rethore, Chrystèle Bodier, Bonnet-Brilhault, Frédérique, Boon, Albert, Braamse, Karen, Breuninger, Ulrike, Buttiglione, Maura, Buttle, Sarah, Cammarano, Marco, Canaway, Alastair, Cantini, Fortunata, Cappellari, Cristiano, Carenini, Marta, Carrà, Giuseppe, Charvin, Isabelle, Chianura, Krizia, Coleman, Philippa, Colonna, Annalisa, Conese, Patrizia, Costanzo, Raffaella, Daffern, Claire, Danckaerts, Marina, Giacomo, Andrea de, Dineen, Peter, Ermans, Jean-Pierre, Farmer, Alan, Fegert, Jörg M., Ferrari, Alessandro, Ferrari, Sabrina, Galea, Giuliana, Gatta, Michela, Gheza, Elisa, Goglia, Giacomo, Grandetto, MariaRosa, Griffin, James, Healy, Elaine, Holmes, Keith, Humbertclaude, Véronique, Ingravallo, Nicola, Invernizzi, Roberta, Jardri, Renaud, Keeley, Helen, Kelly, Caoimhe, Killilea, Meghan, Kirwan, James, Klockaerts, Catherine, Kovač, Vlatka, Lida-Pulik, Hélène, Liew, Ashley, Lippens, Christel, Lynch, Fionnuala, Macchi, Francesca, Manenti, Lidia, Margari, Francesco, Margari, Lucia, Martinelli, Paola, McDonald, James, McFadden, Leighton, Menghini, Deny, Migone, Maria, Miller, Sarah, Monzani, Emiliano, Morini, Giorgia, Mutafov, Todor, Nacinovich, Renata, Negrinotti, Cristina, Nelis, Emmanuel, Neri, Francesca, Nikolova, Paulina, Nossa, Marzia, Noterdaeme, Michele, Operto, Francesca, Panaro, Vittoria, Parenti, Aesa, Pastore, Adriana, Pemmaraju, Vinuthna, Pepermans, Ann, Petruzzelli, Maria Giuseppina, Presicci, Anna, Prigent, Catherine, Rinaldi, Francesco, Riva, Erika, Rivolta, Laura, Roekens, Anne, Rogers, Ben, Ronzini, Pablo, Sakar, Vehbi, Salvetti, Selena, Sandhu, Tanveer, Schepker, Renate, Scocco, Paolo, Siviero, Marco, Slowik, Michael, Smyth, Courtney, Spadone, Maria Antonietta, Speranza, Mario, Stagi, Paolo, Stagni, Pamela, Starace, Fabrizio, Stoppa, Patrizia, Tansini, Lucia, Toselli, Cecilia, Trabucchi, Guido, Tubito, Maria, Dam, Arno van, Gutschoven, Hanne Van, West, Dirk van, Vanni, Fabio, Vannicola, Chiara, Varuzza, Cristiana, Varvara, Pamela, Ventura, Patrizia, Vicari, Stefano, Vicini, Stefania, Bentzel, Carolin von, Wells, Philip, Williams, Beata, Zabarella, Marina, Zamboni, Anna, Zanetti, Edda, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Child and Adolescent Psychiatry / Psychology, Clinical Child and Family Studies, LEARN! - Child rearing, and APH - Mental Health
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Adult ,Internationality ,SAMPLE ,RJ ,child & adolescent psychiatry ,ADOLESCENT ,Jugendpsychiatrie ,Cohort Studies ,SDG 3 - Good Health and Well-being ,ddc:150 ,QUALITY-OF-LIFE ,Psychiatrische Versorgung ,Child psychiatry ,Humans ,Prospective Studies ,SCALE ,Demography ,Retrospective Studies ,Psychiatry ,Internationalität ,OUTCOMES ,DDC 150 / Psychology ,Adolescent psychiatry ,international health services ,General Medicine ,WHOQOL-BREF ,Europe ,Mental Health ,Mental health services ,CROSS ,Adolescent Health Services ,EXPERIENCE ,Kinderpsychiatrie ,adult psychiatry ,RA ,TRANSITION ,RC - Abstract
PurposeThe presence of distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) impacts continuity of mental health treatment for young people. However, we do not know the extent of discontinuity of care in Europe nor the effects of discontinuity on the mental health of young people. Current research is limited, as the majority of existing studies are retrospective, based on small samples or used non-standardised information from medical records. The MILESTONE prospective cohort study aims to examine associations between service use, mental health and other outcomes over 24 months, using information from self, parent and clinician reports.ParticipantsSeven hundred sixty-three young people from 39 CAMHS in 8 European countries, their parents and CAMHS clinicians who completed interviews and online questionnaires and were followed up for 2 years after reaching the upper age limit of the CAMHS they receive treatment at.Findings to dateThis cohort profile describes the baseline characteristics of the MILESTONE cohort. The mental health of young people reaching the upper age limit of their CAMHS varied greatly in type and severity: 32.8% of young people reported clinical levels of self-reported problems and 18.6% were rated to be ‘markedly ill’, ‘severely ill’ or ‘among the most extremely ill’ by their clinician. Fifty-seven per cent of young people reported psychotropic medication use in the previous half year.Future plansAnalysis of longitudinal data from the MILESTONE cohort will be used to assess relationships between the demographic and clinical characteristics of young people reaching the upper age limit of their CAMHS and the type of care the young person uses over the next 2 years, such as whether the young person transitions to AMHS. At 2 years follow-up, the mental health outcomes of young people following different care pathways will be compared.Trial registration numberNCT03013595., publishedVersion
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- 2021
18. Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy
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Al’Aref, Subhi J, primary, Altibi, Ahmed M, additional, Malkawi, Abdallah, additional, Mansour, Munthir, additional, Baskaran, Lohendran, additional, Masri, Ahmad, additional, Rahmouni, Hind, additional, Abete, Raffaele, additional, Andreini, Daniele, additional, Aquaro, Giovanni, additional, Barison, Andrea, additional, Bogaert, Jan, additional, Camastra, Giovanni, additional, Carigi, Samuela, additional, Carrabba, Nazario, additional, Casavecchia, Grazia, additional, Censi, Stefano, additional, Cicala, Gloria, additional, Conte, Edoardo, additional, De Cecco, Carlo N, additional, De Lazzari, Manuel, additional, Di Giovine, Gabriella, additional, Di Roma, Mauro, additional, Dobrovie, Monica, additional, Focardi, Marta, additional, Gaibazzi, Nicola, additional, Gismondi, Annalaura, additional, Gravina, Matteo, additional, Guglielmo, Marco, additional, Lanzillo, Chiara, additional, Lombardi, Massimo, additional, Lorenzoni, Valentina, additional, Lozano-Torres, Jordi, additional, Margonato, Davide, additional, Martini, Chiara, additional, Marzo, Francesca, additional, Masci, Piergiorgio, additional, Masi, Ambra, additional, Memeo, Riccardo, additional, Moro, Claudio, additional, Mushtaq, Saima, additional, Nese, Alberto, additional, Palumbo, Alessandro, additional, Pavon, Anne Giulia, additional, Pedrotti, Patrizia, additional, Pepi, Mauro, additional, Perazzolo Marra, Martina, additional, Pica, Silvia, additional, Pradella, Silvia, additional, Presicci, Cristina, additional, Rabbat, Mark G, additional, Raineri, Claudia, additional, Rodriguez-Palomares, Jose’ F, additional, Sbarbati, Stefano, additional, Schoepf, U Joseph, additional, Squeri, Angelo, additional, Sverzellati, Nicola, additional, Symons, Rolf, additional, Tat, Emily, additional, Timpani, Mauro, additional, Todiere, Giancarlo, additional, Valentini, Adele, additional, Varga-Szemes, Akos, additional, Volpe, Alessandra, additional, Fusini, Laura, additional, Guaricci, Andrea Igoren, additional, Schwitter, Jurg, additional, and Pontone, Gianluca, additional
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- 2022
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19. Infection Risk Evaluation Based on a Novel Scoring System in Chronic Lymphocytic Leukemia (CLL) Patients at Diagnosis
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Roberta Murru, Andrea Galitzia, Giovanni Caocci, Luca Barabino, Roberta Presicci, Fabio Culurgioni, Stefania Massidda, Sara Oppi, and Giorgio La Nasa
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Immunology ,Cell Biology ,Hematology ,Biochemistry - Published
- 2022
20. Depressive risk among Italian socioeconomically disadvantaged children and adolescents during COVID-19 pandemic: a cross-sectional online survey
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Emilia Matera, Anna Presicci, Luigi Quaranta, Lucia Margari, Lucia Marzulli, Maria Serra, Maria Rosaria Erminia Urbano, and Francesco Margari
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Cross-Sectional Studies ,Mental Health ,SOCIOECONOMICALLY DISADVANTAGED ,Adolescent ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,Environmental health ,Pandemic ,COVID-19 ,Humans ,Psychology ,Pandemics - Abstract
Background Children and adolescents and low-income individuals are considered particularly vulnerable for mental health implications during the current COVID-19 pandemic. Depression is a frequent negative emotional response during an epidemic outbreak and is also prone importantly to environmental risk like stressors derived from income inequality. We aimed to assess depressive symptomatology in a sample of Italian low-income minors during the COVID-19 outbreak. We hypothesized that the stronger were the negative effects of the pandemic on socioeconomic conditions, the higher would have been the risk for showing depressive symptoms. Methods We performed a cross-sectional study during July 2020, at the end of the Italian first wave of COVID-19 pandemic. We recruited 109 Italian socioeconomically disadvantaged children and adolescents from 7 to 17 years. We used an online survey to collect socio-demographic and clinical data and information about pandemic-related stressors and to assess depressive symptoms with the Children’s Depression Inventory 2 (CDI 2), Parent Version (Emotional Problems subscale) and Self-Report Short Form. We performed logistic regression analysis to assess the association between depressive symptoms and potential risk factors for mental health. Results 22% and 14% of participants showed depressive symptoms at the CDI 2 Parent Version and Self-Report, respectively. Participants coming from families experiencing a lack of basic supplies during the pandemic (34.9%) were more expected to show depressive symptoms at CDI 2 Parent Version. Participants with a pre-existing neuropsychiatric diagnosis (26.6%) were more likely to exhibit depressive symptoms measured by CDI 2 Parent Version. Conclusions The results of our study showed that a group of Italian socioeconomically disadvantaged children and adolescents were more vulnerable to depressive symptoms if they suffered from a paucity of essential supplies during the pandemic or had pre-existing neurodevelopmental disorders. The promotion of educational and child-care programs and activities could be crucial in sustaining the prevention of mental distress in those frail subjects who particularly need support outside the family. Further studies are needed to detect effective preventive and therapeutic strategies to adopt promptly in the case of another pandemic wave.
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- 2022
21. Associations of High-Sensitivity C-Reactive Protein and Interleukin-6 with Depression in a Sample of Italian Adolescents During COVID-19 Pandemic
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Maria, Serra, Anna, Presicci, Luigi, Quaranta, Mariaclara, Achille, Elvita, Caputo, Silvia, Medicamento, Francesco, Margari, Federica, Croce, and Lucia, Margari
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Many studies highlighted the role of inflammation in the pathogenesis of depression, although not for every patient nor for every symptom. It is widely shared that stressors can increase inflammation and lead to depressive symptoms. Little is known about the symptom-specificity of the inflammation-depression link in adolescence, which we aimed to explore. The single symptom analysis is a core feature of the recent network approach to depression, supposing that psychiatric disorders consist of co-occurring symptoms and their tendency to cause each other.We recruited 52 adolescents diagnosed with a Depressive Disorder during the COVID-19 stressful period. We used regression analysis to measure associations between high sensitivity C-Reactive Protein (hs-CRP) and Interleukin-6 (IL-6) and depressive symptoms assessed by the Children's Depression Inventory 2 (CDI 2). For the study of symptom specificity, we selected 13 items from the CDI 2 Self Report corresponding with the DSM-5 diagnostic criteria for Major Depressive Disorder and we coded them as dichotomous variables to perform a regression analysis.We found that a higher CDI 2-Parent Version total score was significantly predicted by higher hs-CRP (coefficient 3.393;A novel symptom-specificity emerged, with hs-CRP significantly predicting the endorsement of the symptom self-hatred, recognized as a core feature of adolescent depression, following the network theory. We considered it a possible phenotypic expression of one depression endophenotype previously causally linked to inflammation. Due to the limited sample size, these preliminary findings require confirmation with future research focusing on the relationship between inflammation and self-hatred and other central nodes of the depression network, representing an opportunity for targeting interventions on crucial symptoms.
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- 2022
22. Assessing Clinical Features of Adolescents Suffering from Depression Who Engage in Non-Suicidal Self-Injury
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Serra, Maria, primary, Presicci, Anna, additional, Quaranta, Luigi, additional, Caputo, Elvita, additional, Achille, Mariaclara, additional, Margari, Francesco, additional, Croce, Federica, additional, Marzulli, Lucia, additional, and Margari, Lucia, additional
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- 2022
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23. Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy
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Subhi J Al’Aref, Ahmed M Altibi, Abdallah Malkawi, Munthir Mansour, Lohendran Baskaran, Ahmad Masri, Hind Rahmouni, Raffaele Abete, Daniele Andreini, Giovanni Aquaro, Andrea Barison, Jan Bogaert, Giovanni Camastra, Samuela Carigi, Nazario Carrabba, Grazia Casavecchia, Stefano Censi, Gloria Cicala, Edoardo Conte, Carlo N De Cecco, Manuel De Lazzari, Gabriella Di Giovine, Mauro Di Roma, Monica Dobrovie, Marta Focardi, Nicola Gaibazzi, Annalaura Gismondi, Matteo Gravina, Marco Guglielmo, Chiara Lanzillo, Massimo Lombardi, Valentina Lorenzoni, Jordi Lozano-Torres, Davide Margonato, Chiara Martini, Francesca Marzo, Piergiorgio Masci, Ambra Masi, Riccardo Memeo, Claudio Moro, Saima Mushtaq, Alberto Nese, Alessandro Palumbo, Anne Giulia Pavon, Patrizia Pedrotti, Mauro Pepi, Martina Perazzolo Marra, Silvia Pica, Silvia Pradella, Cristina Presicci, Mark G Rabbat, Claudia Raineri, Jose’ F Rodriguez-Palomares, Stefano Sbarbati, U Joseph Schoepf, Angelo Squeri, Nicola Sverzellati, Rolf Symons, Emily Tat, Mauro Timpani, Giancarlo Todiere, Adele Valentini, Akos Varga-Szemes, Alessandra Volpe, Laura Fusini, Andrea Igoren Guaricci, Jurg Schwitter, and Gianluca Pontone
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Science & Technology ,Cardiac & Cardiovascular Systems ,Radiology, Nuclear Medicine & Medical Imaging ,heart failure ,heart failure hospitalization ,Settore MED/11 - Malattie dell'Apparato Cardiovascolare ,General Medicine ,PRESSURE ,cardiac magnetic resonance ,DYSFUNCTION ,EJECTION FRACTION ,ejection fraction ,right ventricular dysfunction ,Cardiovascular System & Cardiology ,HEART-FAILURE ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,Life Sciences & Biomedicine - Abstract
Aims Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) cohorts. While the quantitative assessment of RV function is challenging using 2D-echocardiography, cardiac magnetic resonance (CMR) is the gold standard with its high spatial resolution and precise anatomical definition. We sought to investigate the prognostic value of CMR-derived RV systolic function in a large cohort of HF with reduced ejection fraction (HFrEF). Methods and results Study cohort comprised of patients enrolled in the CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DefibrillAtor ThErapy registry who had HFrEF and had simultaneous baseline CMR and echocardiography (n = 2449). RVSD was defined as RV ejection fraction (RVEF) Conclusion RV systolic dysfunction is an independent predictor of ACM in HFrEF, with a more pronounced prognostic value in select subgroups, likely reflecting the importance of RVSD in the early stages of HF progression.
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- 2021
24. Assessing Clinical Features of Adolescents Suffering from Depression Who Engage in Non-Suicidal Self-Injury
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Maria Serra, Anna Presicci, Luigi Quaranta, Elvita Caputo, Mariaclara Achille, Francesco Margari, Federica Croce, Lucia Marzulli, and Lucia Margari
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Pediatrics, Perinatology and Child Health ,depression ,non-suicidal self-injury ,self-harm ,specifier ,adolescent ,emotional dysregulation ,culture - Abstract
Depressive disorders (DDs) and non-suicidal self-injury (NSSI) are important juvenile mental health issues, showing alarming increasing rates. They frequently co-occur, mainly among adolescents, increasing the suicide risk. We aimed to compare the clinical features of two groups of adolescents with DDs, differed by their engagement or not in NSSI (“DD + NSSI” and “DD”). We hypothesized that NSSI would characterize particularly severe forms of DDs suitable for becoming specific phenotypes of adolescent depression. We enrolled 56 adolescents (11–17 years) diagnosed with a DD according to the DSM-5 criteria. They were assessed for NSSI endorsement (Ottawa Self-Injury Inventory), depressive symptoms (Children’s Depression Inventory 2), emotional dysregulation (Difficulties in Emotional Regulation Scale), and anxiety symptoms (Screen for Child Anxiety-Related Emotional Disorders). The two groups accounted for 31 (“DD + NSSI”) and 25 (“DD”) individuals. The “DD + NSSI” group had significantly higher suicidal ideation (p 0.0039), emotional dysregulation (p 0.0092), depressive symptoms (p 0.0138), and anxiety symptoms (p 0.0153) than the “DD” group. NSSI seemed to characterize more severe phenotypes of adolescent depression, applying for a potential role as a “specifier” of DDs, describing relevant information for their management. Further studies are needed to support this hypothesis and its potential opportunities for prevention and treatment.
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- 2021
25. Depressive and adjustment disorders – some questions about the differential diagnosis: case studies
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A Presicci, P Lecce, P Ventura, and et al
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
A Presicci1, P Lecce1, P Ventura1, F Margari2, S Tafuri3, L Margari11Child Neuropsychiatric Unit, Department of Neurologic and Psychiatric Science, Aldo Moro University of Bari, Bari, Italy; 2Psychiatric Unit, Department of Neurologic and Psychiatric Science, Aldo Moro University of Bari, Bari, Italy; 3Hygiene Section, Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, ItalyBackground: Diagnosis and treatment of mood disorders in youth are still problematic because in this age the clinical presentation is atypical, and the diagnostic tools and the therapies are the same as that used for the adults. Mood disorders are categorically divided into unipolar disorders (major depressive disorder and dysthymic disorder) and bipolar disorder in Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision), but mood symptoms are also comprised in the diagnostic criteria of the adjustment disorder (AD), which occur in many different psychiatric disorders, and may also be found in some physical conditions. The differential diagnosis is not much addressed in the midst of clinical investigation and so remains the major problem in the clinical practice.Aims: The associations between some variables and the depressive disorder and AD were analyzed to make considerations about differential diagnosis.Patients and methods: We reported a retrospective study of 60 patients affected by depressive disorder and AD. The analysis has evaluated the association between some variables and the single diagnostic categories. We have considered 10 variables, of which 6 are specific to the disorders, and 4 have been considered related problems.Results: The statistical analysis showed significant results for the associations of 3 variables (prevalent symptoms, treatment, and family history) with the single diagnostic categories.Conclusion: The discriminate analysis resulted in statistically significant differences between patients with depressive disorders and those with AD on 3 variables, of which 2 are specific to the disorders, and 1 is included in the related problems. The other variables were weakly associated with the single diagnostic categories without any statistically significant differences. The 3 variables that were associated with the single diagnostic categories support the distinct construct validity of the 2 diagnostic categories, but, to date, it is difficult to establish if these variables can be considered diagnostic predictors. On the other hand, the other variables did not support the distinct construct validity of the 2 diagnostic categories, which suggest an overlapping and dimensional concept. The spectrum approach could unify categorical classification that is essential with a dimensional view. Combination of dimensional and categorical principles for classifying mood disorders may help to reduce the problems of underdiagnosis and undertreatment.Keywords: depressive disorder, bipolar disorder, spectrum
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- 2010
26. Omental torsion at the time of COVID-19 in Northern Italy: a case report of conservative management with a review of the pertinent literature
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Filippo, Montali, Renato, Costi, Edoardo, Virgilio, Cristina, Presicci, Carlotta, Sartorio, and Massimo, Pedrazzini
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Male ,Torsion Abnormality ,COVID-19 ,Humans ,Middle Aged ,Appendicitis ,Conservative Treatment ,Peritoneal Diseases ,Omentum - Abstract
In middle-aged men, omental torsion (OT) can be a cause of acute abdomen.The right side of the omentum is longer, heavier and more mobile than the left one and, as a consequence, it can twist more easily on its vascular axis. Consequently, OT localization in the lower right quadrant is more frequent, and therefore it can mimic acute appendicitis clinical onset.In most cases, OT is defined as "primary" in the absence of any other underlying pathologies, or, rarely, "secondary", when caused by other intra-abdominal diseases such as inguinal hernia, tumors, cysts or post-surgical scarring. To date, clinical diagnosis of OT still remains a challenging one in a preoperative setting and most cases are diagnosed intraoperatively. If diagnosis is correctly achieved preoperatively by adequate imaging examinations, most patients presenting with OT do not undergo surgery anymore. Such considerations gain importance at the time of COVID 19 pandemic, where a conservative management and an early discharge may be preferred owing to in-hospital morbidity after abdominal surgery whenever surgery may be avoided.We present a case of an OT successfully treated in a non-operative manner during COVID-19 outbreak in Norhern Italy and offer a review of the literature that supports such a clinical attitude. Conclusions: OT preoperative diagnosis is challenging and is usually achieved by abdominal CT-scan. The suggested OT initial management is conservative, leaving a surgical approach, preferably by laparoscopy, for the 15% of cases not improving with a non-surgical approach.
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- 2021
27. Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
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Presicci, Anna, primary, Serra, Maria, additional, Achille, Mariaclara, additional, Caputo, Elvita, additional, and Margari, Lucia, additional
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- 2021
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28. Depressive Risk among Italian Socioeconomically Disadvantaged Children and Adolescents during Covid-19 Pandemic: A Cross-Sectional Online Survey
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Serra, Maria, primary, Presicci, Anna, additional, Quaranta, Luigi, additional, Urbano, Maria Rosaria Erminia, additional, Marzulli, Lucia, additional, Matera, Emilia, additional, Margari, Francesco, additional, and Margari, Lucia, additional
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- 2021
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29. CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry
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Guaricci, Andrea Igoren, primary, Masci, Pier Giorgio, additional, Muscogiuri, Giuseppe, additional, Guglielmo, Marco, additional, Baggiano, Andrea, additional, Fusini, Laura, additional, Lorenzoni, Valentina, additional, Martini, Chiara, additional, Andreini, Daniele, additional, Pavon, Anna Giulia, additional, Aquaro, Giovanni D, additional, Barison, Andrea, additional, Todiere, Giancarlo, additional, Rabbat, Mark G, additional, Tat, Emily, additional, Raineri, Claudia, additional, Valentini, Adele, additional, Varga-Szemes, Akos, additional, Schoepf, U. Joseph, additional, De Cecco, Carlo N, additional, Bogaert, Jan, additional, Dobrovie, Monica, additional, Symons, Rolf, additional, Focardi, Marta, additional, Gismondi, Annalaura, additional, Lozano-Torres, Jordi, additional, Rodriguez-Palomares, Josè F, additional, Lanzillo, Chiara, additional, Di Roma, Mauro, additional, Moro, Claudio, additional, Di Giovine, Gabriella, additional, Margonato, Davide, additional, De Lazzari, Manuel, additional, Perazzolo Marra, Martina, additional, Nese, Alberto, additional, Casavecchia, Grazia, additional, Gravina, Matteo, additional, Marzo, Francesca, additional, Carigi, Samuela, additional, Pica, Silvia, additional, Lombardi, Massimo, additional, Censi, Stefano, additional, Squeri, Angelo, additional, Palumbo, Alessandro, additional, Gaibazzi, Nicola, additional, Camastra, Giovanni, additional, Sbarbati, Stefano, additional, Pedrotti, Patrizia, additional, Masi, Ambra, additional, Carrabba, Nazario, additional, Pradella, Silvia, additional, Timpani, Mauro, additional, Cicala, Gloria, additional, Presicci, Cristina, additional, Puglisi, Sara, additional, Sverzellati, Nicola, additional, Santobuono, Vincenzo Ezio, additional, Pepi, Mauro, additional, Schwitter, Juerg, additional, and Pontone, Gianluca, additional
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- 2021
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30. GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak
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Weber, Yvonne G., Storch, Alexander, Wuttke, Thomas V., Brockmann, Knut, Kempfle, Judith, Maljevic, Snezana, Margari, Lucia, Kamm, Christoph, Schneider, Susanne A., Huber, Stephan M., Pekrun, Arnulf, Roebling, Robert, Seebohm, Guiscard, Koka, Saisudha, Lang, Camelia, Kraft, Eduard, Blazevic, Dragica, Salvo-Vargas, Alberto, Fauler, Michael, Mottaghy, Felix M., Munchau, Alexander, Edwards, Mark J., Presicci, Anna, Margari, Francesco, Gasser, Thomas, Lang, Florian, Bhatia, Kailash P., Lehmann-Horn, Frank, and Lerche, Holger
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Hemolytic anemia -- Risk factors ,Hemolytic anemia -- Diagnosis ,Gene mutations -- Research ,Movement disorders -- Risk factors ,Movement disorders -- Diagnosis ,Movement disorders -- Care and treatment - Abstract
Paroxysmal dyskinesias are episodic movement disorders that can be inherited or are sporadic in nature. The pathophysiology underlying these disorders remains largely unknown but may involve disrupted ion homeostasis due to defects in cell-surface channels or nutrient transporters. In this study, we describe a family with paroxysmal exertion-induced dyskinesia (PED) over 3 generations. Their PED was accompanied by epilepsy, mild developmental delay, reduced CSF glucose levels, hemolytic anemia with echinocytosis, and altered erythrocyte ion concentrations. Using a candidate gene approach, we identified a causative deletion of 4 highly conserved amino acids (Q282_S285del) in the pore region of the glucose transporter 1 (GLUT1). Functional studies in Xenopus oocytes and human erythrocytes revealed that this mutation decreased glucose transport and caused a cation leak that alters intracellular concentrations of sodium, potassium, and calcium. We screened 4 additional families, in which PED is combined with epilepsy, developmental delay, or migraine, but not with hemolysis or echinocytosis, and identified 2 additional GLUT1 mutations (A275T, G314S) that decreased glucose transport but did not affect cation permeability. Combining these data with brain imaging studies, we propose that the dyskinesias result from an exertion-induced energy deficit that may cause episodic dysfunction of the basal ganglia, and that the hemolysis with echinocytosis may result from alterations in intracellular electrolytes caused by a cation leak through mutant GLUT1., Introduction Paroxysmal dyskinesias (PDs) are characterized by involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. They are classified into paroxysmal kinesigenic dyskinesia (PKD or PKC [...]
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- 2008
31. Acute Disseminated Encephalomyelitis followed by Optic Neuritis: A Rare Syndrome of Uncertain Treatment and Prognosis
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Roberto Palumbi, Maria Serra, Anna Presicci, Lucia Margari, Antonia Peschechera, Mariella Margari, and Martina Fucci
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0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Optic Neuritis ,Encephalomyelitis ,medicine.medical_treatment ,030105 genetics & heredity ,Cochrane Library ,03 medical and health sciences ,0302 clinical medicine ,Prednisone ,Medicine ,Humans ,Optic neuritis ,Spectrum disorder ,business.industry ,Encephalomyelitis, Acute Disseminated ,General Medicine ,Syndrome ,medicine.disease ,Prognosis ,Review article ,Pediatrics, Perinatology and Child Health ,Acute disseminated encephalomyelitis ,Plasmapheresis ,Myelin-Oligodendrocyte Glycoprotein ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Aim Acute Disseminated Encephalomyelitis followed by optic neuritis (ADEM-ON), first described in 2013, is a rare demyelinating syndrome, typical of the pediatric age. We conducted a mini review of the existing literature, focusing on clinical, laboratory, radiological, therapeutic, and prognostic aspects in order to improve the identification of new cases. Methods We searched PubMed and Cochrane Library for studies on ADEM-ON between 2013 and 2018. Results Examination of the reported cases (three case reports and eight observational studies) established the following features. Time between ADEM and ON is highly variable. Almost all patients show antimyelin oligodendrocyte glycoprotein antibody (MOG-abs) seropositivity. High-dose intravenous steroid and plasmapheresis efficacy is reported for the acute phase; oral prednisone and other maintenance drugs may be useful in avoiding relapses. The clinical history may lead to a complete recovery but also to residual deficits. Conclusion MOG-abs detection strongly supports ADEM-ON diagnosis, confirming this entity as part of MOG-abs spectrum disorder. Owing to the very small number of cases so far reported, predicting clinical evolution is very difficult.
- Published
- 2020
32. Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
- Author
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Elvita Caputo, Maria Serra, Anna Presicci, Lucia Margari, and Mariaclara Achille
- Subjects
Pediatrics ,medicine.medical_specialty ,Systemic disease ,neuromyelitis optica ,Case Report ,acquired demyelinating syndromes ,Context (language use) ,myelin oligodendrocyte glycoprotein ,multiple sclerosis ,RJ1-570 ,Myelin oligodendrocyte glycoprotein ,pediatric optic neuritis ,Medicine ,Optic neuritis ,Demyelinating Disorder ,Neuromyelitis optica ,biology ,business.industry ,Multiple sclerosis ,medicine.disease ,Pediatrics, Perinatology and Child Health ,Etiology ,biology.protein ,ADEM-ON ,business - Abstract
Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), such as multiple sclerosis (MS), neuromyelitis optica (NMO), or other syndromes related to the myelin oligodendrocyte glycoprotein IgG antibodies (MOG-IgG). These different PON phenotypes present variable clinical and radiological features, plasma and liquor biomarkers, and prognosis. We describe four pediatric cases presenting clinically with ON, with different etiopathogenetic pictures: one case had a probable infective etiology, while the others were associated with different demyelinating disorders (MS, NMO, syndrome related to MOG-IgG). We discuss the possible evolution of presenting ON in other ADSs, based on recent literature. A careful evaluation of the clinical and investigation findings and the natural course of PON is necessary to define its pathogenic pathway and evolution. Further prolonged follow-up studies are needed to highlight the predictors of PON evolution, its potential sequelae, and the best treatment options.
- Published
- 2021
33. Familial paroxysmal exercise-induced dyskinesia and benign epilepsy: a clinical and neurophysiological study of an uncommon disorder
- Author
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Margari, L., Perniola, T., Illiceto, G., Ferrannini, E., De Iaco, M.G., Presicci, A., Santostasi, R., and Ventura, P.
- Published
- 2000
- Full Text
- View/download PDF
34. Acute Disseminated Encephalomyelitis followed by Optic Neuritis: A Rare Syndrome of Uncertain Treatment and Prognosis
- Author
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Serra, Maria, additional, Presicci, Anna, additional, Fucci, Martina, additional, Margari, Mariella, additional, Palumbi, Roberto, additional, Peschechera, Antonia, additional, and Margari, Lucia, additional
- Published
- 2020
- Full Text
- View/download PDF
35. Computer visualization of risk factors which occur during mining machines assembling in the underground workings
- Author
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Agarwal, A, primary, Aisautov, M, additional, Aisautov, A, additional, Cabala, J, additional, Cmiel, S, additional, Idziak, A, additional, Teper, E, additional, Teper, L, additional, Das, S, additional, Dentoni, V, additional, Massacci, G, additional, Contini, A, additional, Mura, P, additional, Presicci, V, additional, Perra, A, additional, Doronila, A, additional, Osborne, J, additional, Dou, L, additional, Qin, Y, additional, Mu, Z, additional, Galiev, S, additional, Sarsenbaev, E, additional, Daribekov, M, additional, Golosinski, T, additional, Szmigiel, P, additional, Gottfried, J, additional, Shimada, H, additional, Matsui, K, additional, Hennies, W, additional, Guilart, M, additional, Eston, S, additional, da Silva, L, additional, Cort, G, additional, Juettner, Ivanka, additional, Kaved_ija, Boris, additional, Kononov, V, additional, de Beer, M, additional, Létavková, Dagmar, additional, Madeja-Strumi_ska, B, additional, Strumi_ski, A, additional, Malewski, Jerzy, additional, Górniak-Zimroz, Justyna, additional, Migda, J, additional, Muzgina, V, additional, Zharmenov, A, additional, Terlikbaeyva, A, additional, Neustupa, Zden_k, additional, Rashidinejad, F, additional, Sheibani, F, additional, Stalmachová, B, additional, Strako_, V, additional, Tu, S, additional, Zhang, L, additional, Chen, Y, additional, Winkler, T, additional, Michalak, D, additional, and Bojara, S, additional
- Published
- 2004
- Full Text
- View/download PDF
36. THE CONTROL OF AEROSTASIS AND HAEMOSTASIS IN ITERATIVE THORACIC SURGER: THE USE OF FIBRIN GLUE VERSUS STANDARD TECHNIQUES IN A SERIES OF 150 PATIENTS
- Author
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Brega-Massone, Pier P., Ferro, Franca, Magnani, Barbara, Sala, Giuseppe, Presicci, Fabio, and Lequaglie, Cosimo
- Published
- 2006
37. COMPLETION PNEUMONECTOMY FOR LUNG CANCER: ANALYSIS OF RESULTS AND LONG-TERM PROGNOSIS
- Author
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Brega-Massone, Pier P., Ferro, Franca, Magnani, Barbara, Sala, Giuseppe, and Presicci, Fabio
- Published
- 2006
38. Mediastinal-like growing teratoma syndrome
- Author
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DʼAiuto, Massimiliano, Veronesi, Giulia, Peccatori, Fedro Alessandro, Pelosi, Giuseppe, Venturino, Marco, Gasparri, Roberto, Presicci, Fabio, Galetta, Domenico, and Spaggiari, Lorenzo
- Published
- 2005
39. Extended right pneumonectomy with partial left atrial resection for primary leiomyosarcoma of the mediastinum
- Author
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DʼAiuto, Massimiliano, Veronesi, Giulia, Pompilio, Giulio, Gasparri, Roberto, Presicci, Fabio, Galetta, Domenico, Biglioli, Paolo, and Spaggiari, Lorenzo
- Published
- 2005
40. Seamless Geoids across Coastal Zones: Comparison of Satellite and Airborne Gravity across the Seven Continents – and an Azores Heritage Case
- Author
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René Forsberg, Olesen, A., Barnes, D., Ingalls, S., Minter, C., and Presicci, M.
- Abstract
An accurate coastal geoid model is important for determination of near-shore ocean dynamic topography and currents, as well as for land GPS surveys and global geopotential models. Since many coastal regions across the globe are regions of intense development and coastal protection projects, precise geoid models at cmlevel accuracy are essential. The only way to secure cmgeoid accuracies across coastal regions is to acquire more marine gravity data; here airborne gravity is the obvious method of choice due to the uniform accuracy, and the ability to provide a seamless geoid accuracy across the coastline. Current practice for gravity and geoid models, such as EGM2008 and many national projects, is to complement land gravity data with satellite radar altimetry at sea, a procedure which can give large errors in regions close to the coast. To quantify the coastal errors in satellite gravity, we compare results of a large set of recent airborne gravity surveys, acquired across a range of coastal zones globally from polar to equatorial regions, and quantify the errors as a function of distance from the coast line for a number of different global altimetry gravity solutions. We find that accuracy in satellite altimetry solutions depend very much on the availability of gravity data along the coast-near land regions in the underlying reference fields (e.g., EGM2008), with satellite gravity accuracy in the near-shore zone ranging from anywhere between 5 to 20 mGal r.m.s., with occasional large outliers; such errors may typically propagate into coastal geoid errors of 5-10 cm r.m.s. or more, and highlight the needs for airborne gravity surveys in the coastal zones. One of the first examples of such a dedicated effort is the Azores airborne gravity campaign, carried out more than 20 years ago as part of the AGMASCO (Airborne Geoid Mapping System for Coastal Oceanography) EU project 1996-98.
- Published
- 2018
41. Comparative US-MRI evaluation of the Insall–Salvati index
- Author
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Paolo Ricci, Alice Casinelli, Celijeta Tominaj, M. Olive, Elena Maggini, F Giovagnorio, and Cristina Presicci
- Subjects
medicine.medical_specialty ,Insall–Salvati index ,musculoskeletal MRI ,musculoskeletal US ,patellar height ,adolescent ,adult ,aged ,child ,female ,humans ,male ,middle aged ,patella ,magnetic resonance imaging ,ultrasonography ,Correlation coefficient ,Patella tendon ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,030222 orthopedics ,Musculoskeletal MRI ,Musculoskeletal imaging ,business.industry ,Ultrasound ,Mean value ,General Medicine ,Surgery ,Patella ,Nuclear medicine ,business - Abstract
To investigate whether the universally accepted range of normal patellar height ratio derived from MRI for the Insall–Salvati (IS) method could be similarly applied to ultrasound (US). This study included 52 patients (age range 11–75 years) who underwent a bi-modality (US and MRI) examination, with a total of 60 knees evaluated. IS index (ratio of the patella tendon length to length of the patella) was acquired with both methods. Two operators, with different experiences of musculoskeletal imaging and blinded to the results of other investigators, separately performed the MRI and US measurements. For the two operators, MRI reported a mean value of patellar height ratio of 1.10 ± 0.16 (mean ± standard deviation SD), while US a mean value of 1.17 ± 0.16 (mean ± SD). For comparable results, the small addition of 0.16 is needed for the measurements on US compared with MRI. Inter-observer agreements using intra-class correlation coefficient (ICC) was, respectively, 0.97 for MRI and 0.98 for US. The difference of mean values in patellar height ratios between MRI and US was not statistically significant (p = 0.15). The ICC between the two modalities was 0.94. According to our experience, IS index can be appropriately evaluated on US images, reducing the need of other imaging techniques.
- Published
- 2017
42. Cerebral venous thrombosis after lumbar puncture and intravenous high dose corticosteroids: A case report of a childhood multiple sclerosis
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Vincenza Garofoli, Anna Linda Lamanna, Marta Simone, Maria Gloria Campa, Lucia Margari, and Anna Presicci
- Subjects
Multiple Sclerosis ,Adolescent ,medicine.drug_class ,Spinal Puncture ,Magnetic resonance angiography ,Developmental Neuroscience ,Adrenal Cortex Hormones ,Humans ,Medicine ,medicine.diagnostic_test ,business.industry ,Lumbar puncture ,Multiple sclerosis ,Brain ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Radiography ,Venous thrombosis ,Intracranial Thrombosis ,Spinal Cord ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Corticosteroid ,Female ,Neurology (clinical) ,business ,Magnetic Resonance Angiography - Abstract
The association between cerebral venous thrombosis (CVT) and multiple sclerosis (MS) has already been reported in several adult patients with clinically definite MS, in a suspected relation to i.v. corticosteroids or previously performed lumbar puncture (LP). We are reporting a case, which is, to our knowledge, the first one concerning a child patient with a MS, who developed multiple CVT after LP and during high-dose i.v. corticosteroid. Our conclusions are that the sequence LP followed by high dose corticosteroids may be a contributory factor for the development of CVT when associated with other risk factors.
- Published
- 2013
43. Langerhans' cell histiocytosis
- Author
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Fazio, Nicola, Spaggiari, Lorenzo, Pelosi, Giuseppe, Presicci, Fabio, and Preda, Lorenzo
- Subjects
Chest pain -- Risk factors ,Chest pain -- Diagnosis ,Chest pain -- Care and treatment ,Langerhans-cell histiocytosis -- Research ,Medical research ,Medicine, Experimental - Published
- 2005
44. GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak
- Author
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Kailash P. Bhatia, Knut Brockmann, Francesco Margari, Saisudha Koka, Alberto Salvo-Vargas, Felix M. Mottaghy, Christoph Kamm, Mark J. Edwards, Alexander Storch, Eduard Kraft, Snezana Maljevic, Michael Fauler, Guiscard Seebohm, Thomas Gasser, Holger Lerche, Thomas V. Wuttke, Stephan M. Huber, Arnulf Pekrun, Camelia Lang, Anna Presicci, Susanne A. Schneider, Lucia Margari, Judith S. Kempfle, Robert Roebling, Dragica Blazevic, Alexander Münchau, Frank Lehmann-Horn, Yvonne G. Weber, and Florian Lang
- Subjects
Adult ,Male ,Hemolytic anemia ,Anemia, Hemolytic ,medicine.medical_specialty ,Erythrocytes ,Paroxysmal nonkinesigenic dyskinesia ,Xenopus ,Molecular Sequence Data ,Physical Exertion ,Models, Biological ,Chorea ,Cations ,Internal medicine ,medicine ,Animals ,Humans ,Amino Acid Sequence ,Glucose Transporter Type 1 ,biology ,Glucose transporter ,General Medicine ,Paroxysmal dyskinesia ,medicine.disease ,Glucose ,Endocrinology ,PNKD ,Ion homeostasis ,biology.protein ,Female ,GLUT1 ,Research Article - Abstract
Paroxysmal dyskinesias are episodic movement disorders that can be inherited or are sporadic in nature. The pathophysiology underlying these disorders remains largely unknown but may involve disrupted ion homeostasis due to defects in cell-surface channels or nutrient transporters. In this study, we describe a family with paroxysmal exertion-induced dyskinesia (PED) over 3 generations. Their PED was accompanied by epilepsy, mild developmental delay, reduced CSF glucose levels, hemolytic anemia with echinocytosis, and altered erythrocyte ion concentrations. Using a candidate gene approach, we identified a causative deletion of 4 highly conserved amino acids (Q282_S285del) in the pore region of the glucose transporter 1 (GLUT1). Functional studies in Xenopus oocytes and human erythrocytes revealed that this mutation decreased glucose transport and caused a cation leak that alters intracellular concentrations of sodium, potassium, and calcium. We screened 4 additional families, in which PED is combined with epilepsy, developmental delay, or migraine, but not with hemolysis or echinocytosis, and identified 2 additional GLUT1 mutations (A275T, G314S) that decreased glucose transport but did not affect cation permeability. Combining these data with brain imaging studies, we propose that the dyskinesias result from an exertion-induced energy deficit that may cause episodic dysfunction of the basal ganglia, and that the hemolysis with echinocytosis may result from alterations in intracellular electrolytes caused by a cation leak through mutant GLUT1.
- Published
- 2008
45. Clinical and Instrumental (Magnetic Resonance Imaging [MRI] and Multimodal Evoked Potentials) Follow-Up of Brain Lesions in Three Young Patients With Neurofibromatosis 1
- Author
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Lucia Margari, N. Medicamento, T. Perniola, Patrizia Ventura, Simona Maria Bacca, Anna Presicci, Gianni Iliceto, and Maura Buttiglione
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Neurofibromatosis 1 ,Adolescent ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,030225 pediatrics ,medicine ,Humans ,Age of Onset ,Neurofibromatosis ,Child ,Evoked Potentials ,medicine.diagnostic_test ,Brain Neoplasms ,business.industry ,Age Factors ,Brain ,Electroencephalography ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Pediatrics, Perinatology and Child Health ,Brain lesions ,Female ,Neurology (clinical) ,Radiology ,business ,030217 neurology & neurosurgery - Abstract
Diagnosis of neurofibromatosis 1 is based on clinical criteria. In a large number of children with neurofibromatosis 1, magnetic resonance imaging (MRI) reveals high-signal T2-weighted intensities in different brain regions, defined as unidentified bright objects. These lesions are asymptomatic; most of them regress spontaneously with age, but the presence of contrast enhancement or mass effect in them usually strongly suggests an increased risk of proliferative changes. To date, few studies have focused on evoked potentials in patients with neurofibromatosis 1, and the reported abnormalities did not have significant clinical correlations. We describe the clinical and instrumental (MRI and evoked potentials) follow-up of three patients with neurofibromatosis 1. MRI and evoked potentials showed subclinical involvement of the central nervous system. Some MRI T2-weighted hyperintensities showed enhancement and mass effect of uncertain significance. During follow-up, the MRI lesions spontaneously decreased in size or enhancement, allowing us to exclude the hypothesis of proliferative lesions; in the same way, some asymptomatic evoked potential abnormalities disappeared. These findings suggest that both MRI and evoked potentials could be useful in the detection and monitoring of cerebral complications of neurofibromatosis 1.
- Published
- 2006
46. Megalocornea and Mental Retardation Syndrome: Clinical and Instrumental Follow-Up of a Case
- Author
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T. Perniola, Franca Dicuonzo, Lucia Margari, Maura Buttiglione, Caterina Lattarulo, Anna Presicci, and Patrizia Ventura
- Subjects
Pediatrics ,medicine.medical_specialty ,Review Literature as Topic ,Audiology ,Corneal Diseases ,Cerebral palsy ,03 medical and health sciences ,Epilepsy ,Transient hypothyroidism ,Megalocornea ,0302 clinical medicine ,Intellectual Disability ,030225 pediatrics ,medicine ,Humans ,Child ,Follow up studies ,Electroencephalography ,medicine.disease ,Magnetic Resonance Imaging ,Natural history ,Pediatrics, Perinatology and Child Health ,Female ,Neurology (clinical) ,Neuhauser syndrome ,Psychology ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Megalocornea—mental retardation syndrome, otherwise known as Neuhauser syndrome, is a rare autosomal recessive disorder. Only 36 cases have been reported in the literature. We describe the clinical and instrumental follow-up, lasting 5 years, of a case showing the typical features of the syndrome, associated with transient hypothyroidism, epilepsy, cerebral palsy with choreoathetotic movements, and brain malformation. Our report might help better delineate the phenotype and natural history of the syndrome. (J Child Neurol 2006;21:893—896; DOI 10.2310/ 7010.2006.00202).
- Published
- 2006
47. Brain Magnetic Resonance Spectroscopy in Sydenham’s Chorea and ADHD
- Author
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Maura Buttiglione, Claudia Portoghese, Patrizia Ventura, Anna Presicci, Franca Di Cuonzo, and Lucia Margari
- Subjects
Male ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Sydenham's chorea ,Central nervous system ,Creatine ,Choline ,Central nervous system disease ,chemistry.chemical_compound ,Developmental Neuroscience ,Neuroimaging ,Chorea ,Internal medicine ,Basal ganglia ,medicine ,Humans ,Child ,Aspartic Acid ,medicine.diagnostic_test ,Brain ,Magnetic resonance imaging ,medicine.disease ,Endocrinology ,medicine.anatomical_structure ,Neurology ,chemistry ,Attention Deficit Disorder with Hyperactivity ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,medicine.symptom ,Psychology - Abstract
This report presents clinical, laboratory, and neuroimaging findings in a 7-year-old male with Sydenham's chorea associated with attention-deficit hyperactivity disorder. Western immunoblotting revealed serum anti-human basal ganglia tissue antibodies. Magnetic resonance imaging results were normal. Proton magnetic resonance spectroscopic imaging disclosed increased choline/creatine ratio in basal ganglia, frontal, and parieto-occipital areas, and decreased N-acetyl aspartate/creatine ratio in both basal ganglia and frontal areas. Moreover magnetic resonance spectroscopy revealed a peak between 3.6-4.2 ppm of unclear significance. The findings of this study are compared with the previous magnetic resonance spectroscopic studies reported on Sydenham's chorea and attention-deficit hyperactivity disorder. Magnetic spectroscopic imaging suggests an autoimmune basal ganglia damage in the pathogenesis of Sydenham's chorea and fronto-striatal impairment in attention-deficit hyperactivity disorder. In the present case, the previous history of an attention-deficit hyperactivity disorder suggests that this neurobehavioral disorder could be a risk factor for Sydenham's chorea in children with rheumatic fever.
- Published
- 2006
48. Channelopathy: Hypothesis of a common pathophysiologic mechanism in different forms of paroxysmal dyskinesia
- Author
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Francesco Margari, T. Perniola, Patrizia Ventura, Lucia Margari, and Anna Presicci
- Subjects
Male ,Adolescent ,Neurological disorder ,Electroencephalography ,Ion Channels ,Epilepsy ,Developmental Neuroscience ,Channelopathy ,Chorea ,otorhinolaryngologic diseases ,medicine ,Humans ,Corneal reflex ,Evoked Potentials ,Family Health ,medicine.diagnostic_test ,Paroxysmal dyskinesia ,medicine.disease ,Median Nerve ,Neurology ,Dyskinesia ,Somatosensory evoked potential ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,medicine.symptom ,Psychology ,Neuroscience - Abstract
Paroxysmal dyskinesias are a rare heterogeneous group of neurologic disorders, characterized by transient sudden choreoathetoid or dystonic attacks without loss of consciousness. This study reports a family with six affected members in three generations, and two sporadic cases of paroxysmal dyskinesia. Familial cases of paroxysmal dyskinesia are affected by idiopathic long-lasting paroxysmal exertion-induced dyskinesia and the sporadic cases by idiopathic short-lasting paroxysmal kinesigenic dyskinesia. Familial cases also suffer from epilepsy, mainly of generalized type, with benign outcome; one sporadic case is affected by migraine. Results presented in this neurophysiologic study include electromyography, somatosensory evoked potentials by median nerve stimulation, somatosensory evoked potentials by posterior tibial nerve stimulation, motor evoked potentials by magnetic transcranial cortical stimulation, visual evoked potentials, brainstem auditory evoked potentials, blink reflex, reflex H, and electroencephalography. The clinical and neurophysiologic findings presented here suggest a condition of hyperexcitability at the muscular and brain level, perhaps as a result of an ion channel disorder, which is in agreement with reports in the literature.
- Published
- 2005
49. Congenital ataxia and mental retardation in three brothers
- Author
-
Patrizia Ventura, Lucia Margari, T. Perniola, Anna Presicci, and Maura Buttiglione
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Pediatrics ,medicine.medical_specialty ,Ataxia ,Adolescent ,Developmental Disabilities ,Neurological disorder ,Central nervous system disease ,Developmental Neuroscience ,Cerebellum ,Intellectual Disability ,medicine ,Humans ,Child ,Cerebral Cortex ,Genetic heterogeneity ,Siblings ,medicine.disease ,Magnetic Resonance Imaging ,Hypoplasia ,Developmental disorder ,Neurology ,Pediatrics, Perinatology and Child Health ,Cerebellar vermis ,Etiology ,Neurology (clinical) ,medicine.symptom ,Psychology ,Neuroscience - Abstract
Nonprogressive congenital ataxia is a complex group of disorders caused by a variety of etiologic factors, both environmental and genetic. Hereditary forms represent a substantial part of congenital ataxias, which are difficult to classify because of their phenotypic and genetic polymorphism. Despite the advances in molecular genetics, for most nonprogressive congenital ataxia the etiology is still unknown. This report describes three sons of nonconsanguineous healthy parents, who manifested a syndrome characterized by nonprogressive ataxia, mental retardation, pyramidal signs, ocular and ocular motor anomalies, associated with severe hypoplasia of the cerebellar vermis and hemispheres on neuroimaging. All the patients have presented psychomotor developmental delay. As differential diagnosis, a comparison is made between the clinical features of these patients and the previously reported cases of nonprogressive congenital ataxia. This report represents a further example of the phenotypic and genetic heterogeneity of the syndromes with congenital ataxia.
- Published
- 2004
50. Love addiction and sexual satisfaction within the attachment perspective: an empirical contribution.
- Author
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Rogier, Guyonne, Di Marzio, Ferdinando, Presicci, Christian, Cavalli, Roberta Gabriella, and Velotti, Patrizia
- Abstract
This study aims to test the predictive capacity of the attachment theory in delineating the line between normal and pathological love as well as testing the moderating role of gender in the link between insecure attachment and sexual satisfaction. We administered to a sample of 307 adults the Attachment Style Questionnaire (ASQ), the Love Addiction Inventory (LAI), the Passionate Love Scale (PLS), and the New Sexual Satisfaction Scale (NSSS). We found that some subscales of the ASQ predict LAI scores and that the relationship between passionate love and love addiction was positively moderated by insecure styles of attachment (i.e. discomfort for closeness, preoccupation for relationships, and need for approval). In addition, insecure attachment was negatively related to sexual satisfaction. However, moderation analyses evidenced that the relationship between attachment avoidance and low sexual satisfaction was positive only among males. The study confirmed the utility of the attachment perspective in the understanding of the processes underlying romantic relationships. Results also suggest that the quality of attachment style may be a key factor in differentiating normal from pathological love and that the impact of avoidant attachment style on sexual satisfaction may follow different pathways according to gender. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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