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Your search keyword '"Prenylbisabolane"' showing total 10 results
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10 results on '"Prenylbisabolane"'

1. Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with significant in vitro anti-neuroinflammatory activity.

Author

Jiménez-Romero, Carlos, Mayer, Alejandro M.S., and Rodríguez, Abimael D.

Subjects
*DITERPENES, *IN vitro studies, *ANTI-inflammatory agents, *NEUROLOGICAL disorders, *THERAPEUTICS, *THROMBOXANES, *ESCHERICHIA coli
Abstract

Abstract: A new regular diterpene possessing an unusual 1,6-anti-3-methylcyclohex-2-en-1-ol ring system, dactyloditerpenol acetate (1), has been extracted from the tropical sea hare Aplysia dactylomela and its stereostructure elucidated by spectroscopic methods. The absolute configuration of 1 was determined as 1S, 6S, 7R, 10S, and 11R by application of Kishi’s method for the assignment of absolute configuration of alcohols. The new diterpene potently inhibited in vitro thromboxane B2 (TXB2) (IC50 0.4μM) and superoxide anion (IC50 1μM) generation from Escherichia coli lipopolysaccharide (LPS)-activated rat neonatal microglia, with concomitant low short-term toxicity. [Copyright &y& Elsevier]

Published
2014
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2. A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria)

Author

Campagnuolo, Claudio, Fattorusso, Ernesto, Petrucci, Francesca, Taglialatela-Scafati, Orazio, Appendino, Giovanni, Marquez, Nieves, and Muñoz, Eduardo

Subjects
*CASCARILLA, *CYTOKINES, *TUMOR necrosis factors, *T cells, *GROWTH factors
Abstract

Abstract: Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-κB by tumor necrosis factor-α in T cells. [Copyright &y& Elsevier]

Published
2005
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3. Claoxylones A–I, prenylbisabolane diterpenoids with anti-Coxsackie B virus activity from the branches and leaves of Claoxylon polot

Author

Li Li, Yu-Huan Li, Shuang-Gang Ma, Yong Li, Jian-Dong Jiang, Xiaoguang Chen, Yun-Bao Liu, Hong-Shun Gu, Shi-Shan Yu, Ya-Dan Wang, Haining Lv, and Jing Qu

Subjects
Circular dichroism, Claoxylon polot, Chemistry, Stereochemistry, Organic Chemistry, medicine.disease_cause, Biochemistry, Virus, chemistry.chemical_compound, Prenylbisabolane, Furan, Drug Discovery, X-ray crystallography, medicine, Coxsackie B virus, Tetrahydrofuran
Abstract

Nine new prenylbisabolane diterpenoids, claoxylones A–I (1–9), were isolated from the branches and leaves of Claoxylon polot. This is the first example of prenylbisabolane diterpenoids with furan and tetrahydrofuran rings. Their structures and relative configurations were established by spectroscopic and conformational analysis, and the absolute configurations were determined by single-crystal X-ray diffraction and electronic circular dichroism (ECD) analysis. Compounds 1–9 exhibited antiviral activity against Coxsackie B3 virus, with IC50 values of 6.0–33.3 μM.

Published
2014
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4. Amitorines A and B, Nitrogenous Diterpene Metabolites of Theonella swinhoei: Isolation, Structure Elucidation, and Asymmetric Synthesis

Author

Hiroaki Miyaoka, Yukiko Hamamoto, Wakiko Eda, Kazuo Kamaike, Hidemichi Mitome, Ayako Hoshino, Koichiro Ota, Akiyoshi Sawada, and Kenta Tamura

Subjects
Stereochemistry, Pharmaceutical Science, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, Prenylbisabolane, Amitorine B, Japan, Drug Discovery, Organic chemistry, Animals, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, chemistry.chemical_classification, Bicyclic molecule, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Enantioselective synthesis, Diastereomer, Theonella swinhoei, 0104 chemical sciences, Complementary and alternative medicine, chemistry, Molecular Medicine, Diterpene, Diterpenes, Theonella, Lactone
Abstract

Two new nitrogenous prenylbisabolanes never before found in Lithistid sponges have been isolated from Theonella swinhoei. These new diterpenes, named amitorine A (1) and amitorine B (2), containing a prenylbisabolane skeleton have been characterized by spectroscopic analyses, and the relative and absolute configurations of 1 and 2 were determined by asymmetric synthesis of both diastereomers via the common bicyclic lactone 6 intermediate.

Published
2016

6. A new diterpene enone from the soldier beetle Cantharis livida (Coleoptera: Cantharidae)

Author

Jean-Luc Dimarcq, Christophe Durvaux, Désiré Daloze, Jacques Pasteels, Roland Lupoli, Pascal Laurent, and Jean Claude Braekman

Subjects
biology, Stereochemistry, Chemistry, media_common.quotation_subject, Organic Chemistry, Spectral properties, Insect, biology.organism_classification, lcsh:QD241-441, chemistry.chemical_compound, Cantharis livida, Prenylbisabolane, lcsh:Organic chemistry, Diterpene, Enone, Soldier beetle, media_common
Abstract

Cantharenone 1, a new diterpene structurally related to the prenylbisabolane skeleton, has been isolated from the beetle Cantharis livida (Cantharidae). Its structure has been determined on the basis of its spectral properties. This is the first report of such a type of diterpenoid from an insect. ©ARKAT-USA, Inc.

Published
2006
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8. A new diterpene enone from the soldier beetle Cantharis livida (Coleoptera: Cantharidae)

Author

Durvaux, Christophe, Laurent, Pascal, Daloze, Désiré, Braekman, Jean Claude, Lupoli, Roland, Dimarcq, Jean-Luc, Pasteels, Jacques, Durvaux, Christophe, Laurent, Pascal, Daloze, Désiré, Braekman, Jean Claude, Lupoli, Roland, Dimarcq, Jean-Luc, and Pasteels, Jacques

Abstract

Cantharenone 1, a new diterpene structurally related to the prenylbisabolane skeleton, has been isolated from the beetle Cantharis livida (Cantharidae). Its structure has been determined on the basis of its spectral properties. This is the first report of such a type of diterpenoid from an insect. ©ARKAT-USA, Inc., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2007

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