125 results on '"Prentakis A"'
Search Results
2. Double Trouble: Association of Malignant Melanoma with Sporadic and Genetic Forms of Parkinson’s Disease and Asymptomatic Carriers of Related Genes: A Brief Report
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Christos Koros, Athina-Maria Simitsi, Anastasia Bougea, Nikolaos Papagiannakis, Roubina Antonelou, Ioanna Pachi, Efthalia Angelopoulou, Andreas Prentakis, Athena Zachou, Chrysa Chrysovitsanou, Ion Beratis, Stella Fragkiadaki, Dionysia Kontaxopoulou, Efthymia Eftymiopoulou, Evangelia Stanitsa, Constantin Potagas, Sokratis G. Papageorgiou, Efstratios Karavasilis, Georgios Velonakis, Vasilios Prassopoulos, Xenia Geronicola-Trapali, and Leonidas Stefanis
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Parkinson’s disease ,malignant melanoma ,Leucine Rich Repeat Kinase 2 ,Glucocerebrosidase ,genetic ,Medicine (General) ,R5-920 - Abstract
Introduction: Previous epidemiological evidence has established the co-occurrence of malignant melanoma (MM) and Parkinson’s disease (PD). Shared molecular mechanisms have been proposed to be implicated in this relationship. The aim of the present study was to assess the prevalence of MM in patients with sporadic and genetic types of PD, as well as in asymptomatic carriers of PD-related genes. Methods: Data regarding past medical history and concomitant disease of 1416 patients with PD (including 20 participants with prodromal disease who phenoconverted to PD), 275 healthy controls (HCs) and 670 asymptomatic carriers of PD-related genes were obtained from the database of the Parkinson’s Progression Markers Initiative (PPMI). Focus was placed on information about a medical record of MM. We also retrieved data regarding the genetic status of selected PPMI participants with a positive MM history. Results: In total, 46 patients with PD reported a positive MM history. Concerning the genetic forms of PD, nine of these PD patients (2.47%) carried a Leucine Rich Repeat Kinase 2 (LRRK2) gene mutation (mainly the G2019S), while eight (4.49%) harbored a Glucocerebrosidase (GBA) gene mutation (mainly the N370S). No alpha-synuclein (SNCA) gene mutation was identified in patients with an MM history. The remaining 29 PD patients (3.5%) were genetically undetermined. In total, 18 asymptomatic carriers of PD-related genes had a positive medical history for MM: among them, 10 carried an LRRK2 gene mutation (2.69%) and 10 a GBA gene mutation (3.51%) (2 were dual carriers). MM history was identified for seven HCs (2.5%). Conclusions: We replicated the previously reported association between genetically undetermined PD (GU-PD) and MM. A correlation of LRRK2 mutations with the development of MM could not be verified in either symptomatic PD patients or asymptomatic carriers, implicating distinct pathogenetic mechanisms as compared to GU-PD. Importantly, despite the limited literature evidence on Gaucher disease, this study highlights for the first time the relatively high prevalence of MM among asymptomatic and symptomatic PD GBA mutation carriers, with potential clinical implications.
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- 2023
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3. Implementation of Artificial Intelligence Assessment in Engineering Laboratory Education
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Samarakou, Maria, Fylladitakis, Emmanouil D., Prentakis, Pantelis, and Athineos, Spyros
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In laboratory courses, the assessment of exercises and assignments typically is treated as a simple, quantifiable approach. This approach however rarely includes qualitative factors, especially if the grading is being automatically performed by the system, and provides little to no feedback for the students to reflect on their work. The role of the laboratory in engineering education however is very critical and engineering students must possess knowledge that goes beyond mere theory, therefore a diverse and multidimensional assessment of laboratory students is a necessity. In this paper, an educational tool for laboratory students implementing automatic assessment based on artificial intelligence is being proposed, based on a pilot version that has been developed for MATLAB-related coursework. The highlights of the proposed tool is that it is based on a proven cognitive theory, it is easy to compile and or modify its contents, it is based on the same laboratory environment that the students are being trained in, it can include qualitative evaluation and it can save time that the educators would otherwise require to manually evaluate the exercises. [Partial funding for this research was provided by Greek national resources under the framework of the "Archimedes III: Funding of Research Groups in TEI of Athens" project of the "Education & Lifelong Learning" Operational Programme.] [For the complete proceedings, see ED557189.]
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- 2014
4. DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study
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Koros, Christos, Simitsi, Athina-Maria, Prentakis, Andreas, Papagiannakis, Nikolaos, Bougea, Anastasia, Pachi, Ioanna, Papadimitriou, Dimitra, Beratis, Ion, Papageorgiou, Sokratis G., Stamelou, Maria, Trapali, Xenia Geronicola, and Stefanis, Leonidas
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- 2020
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5. Adaptation of Educational Text to an Open Interactive Learning System: A Case Study for ReTuDiS
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Samarakou, M., Fylladitakis, E. D., Tsaganou, G., Gelegenis, J., Karolidis, D., and Prentakis, P.
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Theoretical education is mainly based on university text-books, which usually include texts not structured according to any theory of text comprehension. Structuring a text is a demanding process. Text should be organized and structured in order to include descriptions on micro and macro-level representation of the knowledge domain. Since this is difficult, diagnosis of text comprehension can lie heavily on the construction of the appropriate questions and dialogue structure about a not structured text. This may also affect students' performance on laboratory education. Whereas traditional educational systems infer the reasons for the student's behavior without directly involving the student, current educational systems, supported by interactive learning programs, attempt to involve students in the process of diagnosis. This paper presents the adaptation process of a non-structured text to ReTuDiS, an open interactive learning system which is being experimentally used today as an diagnostic, profiling and support system for undergraduate students. [For the full proceedings, see ED562127.]
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- 2013
6. Application of fuzzy logic for the assessment of engineering students.
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Maria Samarakou, Pantelis Prentakis, Dimitrios Mitsoudis, Dimitrios Karolidis, and Spyros Athinaios
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- 2017
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7. Double Trouble: Association of Malignant Melanoma with Sporadic and Genetic Forms of Parkinson’s Disease and Asymptomatic Carriers of Related Genes: A Brief Report
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Koros, Christos, primary, Simitsi, Athina-Maria, additional, Bougea, Anastasia, additional, Papagiannakis, Nikolaos, additional, Antonelou, Roubina, additional, Pachi, Ioanna, additional, Angelopoulou, Efthalia, additional, Prentakis, Andreas, additional, Zachou, Athena, additional, Chrysovitsanou, Chrysa, additional, Beratis, Ion, additional, Fragkiadaki, Stella, additional, Kontaxopoulou, Dionysia, additional, Eftymiopoulou, Efthymia, additional, Stanitsa, Evangelia, additional, Potagas, Constantin, additional, Papageorgiou, Sokratis G., additional, Karavasilis, Efstratios, additional, Velonakis, Georgios, additional, Prassopoulos, Vasilios, additional, Geronicola-Trapali, Xenia, additional, and Stefanis, Leonidas, additional
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- 2023
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8. Serum Uric Acid as a Putative Biomarker in Prodromal Parkinson’s Disease: Longitudinal Data from the PPMI Study
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Koros, Christos, primary, Simitsi, Athina-Maria, additional, Papagiannakis, Nikolaos, additional, Bougea, Anastasia, additional, Prentakis, Andreas, additional, Papadimitriou, Dimitra, additional, Pachi, Ioanna, additional, Beratis, Ion, additional, Stanitsa, Evangelia, additional, Angelopoulou, Efthalia, additional, Antonelou, Roubina, additional, Bregianni, Marianna, additional, Lourentzos, Konstantinos, additional, Papageorgiou, Sokratis G., additional, Bonakis, Anastasios, additional, Trapali, Xenia Geronicola, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional
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- 2023
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9. Medication adherence in relation with physical activity in hypertensive patients : data from a behavioral cardiology unit
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Fragoulis, C, primary, Prentakis, A G, additional, Kontogianni, E, additional, Polyzos, D, additional, Tsioufis, P A, additional, Fragouli, D, additional, Leontsinis, I, additional, Mantzouranis, E, additional, Sakalidis, A, additional, Mavroudis, A, additional, Kalos, T, additional, Chrysochoou, C, additional, Politis, A, additional, and Tsioufis, K P, additional
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- 2023
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10. Medication adherence in relation with physical activity in hypertensive patients : data from a behavioral cardiology unit
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C Fragoulis, A G Prentakis, E Kontogianni, D Polyzos, P A Tsioufis, D Fragouli, I Leontsinis, E Mantzouranis, A Sakalidis, A Mavroudis, T Kalos, C Chrysochoou, A Politis, and K P Tsioufis
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Epidemiology ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background/Introduction Few studies have examined the relationship between exercise and adherence to antihypertensive medication, examining all possible factors contributing to blood pressure control. Purpose The purpose of our study was to access the possible dependence relationship among hypertensive patients visiting the Behavioral Cardiology Unit in a Tertiary Hospital. Methods The study population consisted of patients reporting to the Behavioral Cardiology Unit in a Tertiary Hospital during a period of 6 months in 2021. In terms of holistic approach, all patients underwent a thorough clinical in-depth interview, using the Morisky Medication Adherence Scale (MMAS8), the Frail Questionnaire Screening Tool (Frailty Score) and the Patient Health Questionnaire-4 (PHQ-4). All patients also provided full history of exercise (at least 150 minutes of physical activity or 75 minutes of intense activity per week), while completing the Duke Activity Status Index (DASI). Results The population consisted of 42 hypertensive patients, 54.8% of them were females, with a mean age of all patients at 55.8±15.2 years. Body Mass Index was averaging at 27.6 kg/m2. Salt consumption above the daily suggested amount (>5gr/day) was reported by 60% of patients, binge drinking by 43% of them, while 43% had a history of active smoking. High adherence was reported by 17 patients (46%), medium adherence by 14 (37.8%) and low adherence by 6 (16.2%). Results indicate a relationship between exercise and adherence to medication. More specifically, Chi-Square test showed statistical significance between exercise and medium medication adherence in MMAS8 (MMAS8: 6-7, p=0.033). Moreover, statistical analysis showed significant relationship between exercise, frailty and PHQ-4 score. Particularly, patients with absence of exercise showed higher level of PHQ-4 score (F=7.07, p=0.011). Conclusions Our study highlights the possible dependency relationship of exercise and adherence to medication. Results indicate that patients with good adherence to medication have better behavioral activation. There is need for further research in this domain, to confirm the findings.
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- 2023
11. Assessing students approaches in the context of telecommunications services provision.
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Andreas E. Papadakis, Nikolaos D. Tselikas, Maria Samarakou, and Pantelis Prentakis
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- 2015
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12. How an open learning environment affects the motivation of secondary and higher education students.
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Maria Samarakou, Emmanouil D. Fylladitakis, Dimitrios Karolidis, Andreas E. Papadakis, Pantelis Prentakis, and Grammatiki Tsaganou
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- 2015
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13. PS-C08-10: RELATIONSHIP OF PHYSICAL ACTIVITY AND MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS: BEHAVIORAL CARDIOLOGY UNIT DATA
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Fragoulis, Christos, primary, Kontogianni, Evangelia, additional, Prentakis, Andreas, additional, Polyzos, Dimitrios, additional, Kariori, Maria, additional, Kalos, Theodoros, additional, Mantzouranis, Emmanouil, additional, Leontsinis, Ioannis, additional, Chrysochoou, Christina, additional, Politis, Antonios, additional, and Tsioufis, Konstantinos, additional
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- 2023
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14. Education, training, and professional issues of radiographers in six European countries: a comparative review
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Andreas G. Prentakis, Antonis P. Stefanoyiannis, Kostas Georgiadis, Louise Coleman, Shane J. Foley, Daniela Herlig, Photis Kollas, Anna Kowalik, Jolanta Tomczak, and Sofia N. Chatziioannou
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radiographer ,education ,training ,practice ,continuing professional development ,Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Radiographers constitute an important part of a multidisciplinary radiation-based imaging and therapy chain. However, is there a common framework for assuring high education, training, and subsequent practice of profession among European countries? A study was conducted, based on a questionnaire that consisted of three parts, concerning education and training (Part A), national registry (Part B), and professional issues (Part C). Analysis of the collected data suggested that a common policy is generally followed in the countries investigated; however, differences were not negligible. A common framework of educational programmes among European countries could form the basis for overall standardisation at national and international level.
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- 2016
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15. Enhancing laboratory experience and assessment through monitoring and processing of students' activities.
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Andreas E. Papadakis, Maria Samarakou, Pantelis Prentakis, Nikolaos D. Tselikas, and Grammatiki Tsaganou
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- 2013
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16. The international context of education, training and certification for medical physicists in Europe, North America and Australasia
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Geoghegan, D. S., Stefanoyiannis, A. P., Christofides, S., Psichis, K., Gerogiannis, I., Round, W. H., Geronikola-Trapali, X., Armeniakos, I., Kaplanis, P. A., Prentakis, A., Chatziioannou, S. N., and Long, Mian, editor
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- 2013
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17. Protection of Human Health and the Environment by Means of Predisposal Management of Medical Solid Radioactive Waste
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Stefanoyiannis, A. P., Gerogiannis, I., Christofides, S., Koutroumpis, G., Geronikola-Trapali, X., Chatziioannou, S. N., Bakas, A., Armeniakos, I., Prentakis, A., Bakalis, S., Magjarevic, Ratko, editor, Dössel, Olaf, editor, and Schlegel, Wolfgang C., editor
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- 2009
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18. Education and Training of Medical Physicists in Europe and the Countries of North America: Similarities-Differences-General Guidelines
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Stefanoyiannis, A. P., Psichis, C., Gerogiannis, I., Christofides, S., Kaplanis, P. A., Geronikola-Trapali, X., Chatziioannou, S. N., Armeniakos, I., Prentakis, A., Magjarevic, Ratko, editor, Dössel, Olaf, editor, and Schlegel, Wolfgang C., editor
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- 2009
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19. DEPENDENCY RELATIONSHIP OF EXERCISE AND MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS
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Fragoulis, Christos, primary, Prentakis, Andreas G., additional, Kontogianni, Evangelia, additional, Polyzos, Dimitrios, additional, Leontsinis, Ioannis, additional, Mantzouranis, Emmanouil, additional, Kalos, Theodoros, additional, Politis, Antonios, additional, and Tsioufis, Konstantinos, additional
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- 2022
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20. The Education and training of clinical medical physicists in 25 European, 2 North American and 2 Australasian countries: Similarities and differences
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Stefanoyiannis, A.P., Christofides, S., Psichis, K., Geoghegan, D.S., Gerogiannis, I., Round, W.H., Geronikola-Trapali, X., Armeniakos, I., Kaplanis, P.A., Prentakis, A., and Chatziioannou, S.N.
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- 2012
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21. CARDIORESPIRATORY INDICES IN RELATION TO MARKERS OF PSYCHOPATHOLOGY AND NEUROCOGNITIVE FUNCTION IN POST SARS-COV-2 INFECTED SUBJECTS
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Fragoulis, Christos, primary, Kariori, Maria, additional, Prentakis, Andreas G., additional, Kontogianni, Evangelia, additional, Leontsinis, Ioannis, additional, Valatsou, Aggeliki, additional, Konstantinidis, Dimitris, additional, Pirounaki, Maria, additional, Aggeli, Constadina, additional, Chrysochoou, Christina, additional, Politis, Antonios, additional, Vassilopoulos, Dimitrios, additional, and Tsioufis, Konstantinos, additional
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- 2022
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22. PS-C08-10: RELATIONSHIP OF PHYSICAL ACTIVITY AND MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS: BEHAVIORAL CARDIOLOGY UNIT DATA
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Christos Fragoulis, Evangelia Kontogianni, Andreas Prentakis, Dimitrios Polyzos, Maria Kariori, Theodoros Kalos, Emmanouil Mantzouranis, Ioannis Leontsinis, Christina Chrysochoou, Antonios Politis, and Konstantinos Tsioufis
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Physiology ,Internal Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
23. Serum uric acid and total bilirubin as putative biomarkers of resistance in Prodromal Parkinson’s disease: Longitudinal data from the PPMI study
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Christos Koros, Athina-Maria Simitsi, Anastasia Bougea, Nikolaos Papagiannakis, Andreas Prentakis, Dimitra Papadimitriou, Ioanna Pachi, Efthalia Angelopoulou, Ion Beratis, Efthymia Efthymiopoulou, Konstantinos Lourentzos, Maria Bozi, Sokratis G. Papageorgiou, Xenia Geronicola Trapali, Anastasios Bonakis, Maria Stamelou, and Leonidas Stefanis
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BackgroundThe role of blood uric acid and more recently bilirubin as biomarkers in symptomatic motor PD has been increasingly established in the literature.ObjectiveOur present study assessed the role of serum uric acid and total bilirubin as putative biomarkers in a prodromal PD cohort followed longitudinally.MethodsLongitudinal 5-year serum uric acid and total bilirubin measurement data of 65 Prodromal PD patients (including REM Sleep Behavior disorder (RBD), N=39 and Hyposmia, N=26) with an abnormal DATSCAN imaging were downloaded from the Parkinson’s Progression Markers Initiative (PPMI) database. This cohort was compared with 423 de novo sporadic PD patients and 196 healthy controls enrolled in the same study.ResultsAfter adjusting for age, sex and Body Mass Index (BMI), baseline and 5-year longitudinal serum uric acid levels were higher in the Prodromal cohort and RBD subgroup as compared to the motor PD cohort. This was also true for longitudinal measurements in the Hyposmic subgroup. In contrast, baseline and longitudinal serum total bilirubin did not differ between each prodromal group and the PD cohort.ConclusionsOur results are indicative of a role of serum uric acid (but probably not of total bilirubin) as a marker of neuroprotection, in a certain subgroup of premotor patients exhibiting exclusively non motor features (hyposmia or RBD). It is possible that an inherent antioxidant resistance of a subset of RBD or hyposmia patients with high serum uric acid level delayed or precluded the emergence of a motor PD phenotype as opposed to the PD cohort.
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- 2021
24. Serum uric acid and total bilirubin as putative biomarkers of resistance in Prodromal Parkinson’s disease: Longitudinal data from the PPMI study
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Koros, Christos, primary, Simitsi, Athina-Maria, additional, Bougea, Anastasia, additional, Papagiannakis, Nikolaos, additional, Prentakis, Andreas, additional, Papadimitriou, Dimitra, additional, Pachi, Ioanna, additional, Angelopoulou, Efthalia, additional, Beratis, Ion, additional, Efthymiopoulou, Efthymia, additional, Lourentzos, Konstantinos, additional, Bozi, Maria, additional, Papageorgiou, Sokratis G., additional, Trapali, Xenia Geronicola, additional, Bonakis, Anastasios, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional
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- 2021
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25. Education and Training of Medical Physicists in Europe
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P. A. Kaplanis, A. Prentakis, I. Armeniakos, X. Geronikola -Trapali, C. Psichis, I. Gerogiannis, A.P.Stefanoyiannis, and S. Christofides
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medical physics ,training ,education ,guidelines ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Technology (General) ,T1-995 - Abstract
Introduction: Medical Physicist, as a professional who works in a hospital environment, is a member of a wide clinical team which is responsible for the correct diagnosis and the therapeutic methods applied using radiation. The role of a Medical Physicist is multifold and consists of the estimation of the dose received by patients and personnel, the quality control of radiological equipment, the studies for shielding requirements and the training of several health professionals (doctors, medical physicists, radiologists, technicians, nurses). All the above are prerequisites in order to receive the professional license to act as Medical Physicist.Aim-Research Inquires: The aim of European Union (EU) via European Federation of Medical Physics (EFOMP) is to apply a common policy among the EU countries in the area of Education and Training in Medical Physics within the context of the current developments in the European Higher Education Area arising from “The Bologna Declaration”. A short-term perspective is the free movement of professionals within EU, via the assurance of knowledge and skills uniformity. A necessary preliminary stage is the collection, classification and further process of relevant information at the European level.Methods-Techniques: To achieve the above in an efficient way EFOMP prepared a questionnaire and sent it to the National Organisation for Medical Physics of each country member of EFOMP (NMO). 23 out of 34 country members responded. The main parts (3 in total) of this questionnaire and some typical questions were:Part A: Medical Physics Education•Which degree is required? Is this a university degree? How many years of studies does it represent?•Is there a nationally approved education programme and, if yes, then by whom?•Where do the education and training take place (University, Hospital, or both of them)? Are these centers accredited and who gives the accreditation?Part B: Qualified / Specialist Medical Physicist•Is there a license or diploma required to work as Medical Physicist? Is it officially provided (i.e. government)?Part C: Register of Medical Physicists•Is there a Register of Medical Physicists in the country? If yes, how is someone registered?•Is there a renewal mechanism in the Register? If yes, is it based on a Continuing Professional Development system (CPD)?Results (Summarised):•In all countries that responded in this questionnaire, the basic educational requirement to enter Medical Physics is a university degree (basic titles: BSc 30%, MSc 57%).•There are 3 different approaches concerning post-graduate education and training (university studies only 23%, hospital only 18% and combining university and hospital 59%).•In 61% of all countries it is mandatory to hold a diploma or license to work as a Medical Physicist.•65% of all countries have an organised Register for Medical Physicists.•A formal CPD programme is in operation in 52% of the countries.Conclusions: The processing of the above results leads the EFOMP to propose some general guidelines. It is strongly recommended that holding a university Masters degree (MSc) and having 2 years’ training in a hospital environment are the necessary requirements to take the license to act as a Medical Physicist. EFOMP strongly encourages NMO’s to organise a formal CPD programme and to include a CPD-based renewal mechanism for the Register of Medical Physicists.
- Published
- 2008
26. Apathy: an underestimated feature in GBA and LRRK2 non-manifesting mutation carriers
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Andreas Prentakis, Maria Stamelou, Ioanna Pachi, Dimitra Papadimitriou, Nikolaos Papagiannakis, Athina Simitsi, Sokratis G. Papageorgiou, Anastasia Bougea, Christos Koros, Xenia Geronicola Trapali, Maria Bozi, Ion Beratis, Efthalia Angelopoulou, Leonidas Stefanis, and Roubina Antonelou
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Male ,Heterozygote ,medicine.medical_specialty ,Parkinson's disease ,Databases, Factual ,Demographics ,Apathy ,Disease ,Neuropsychological Tests ,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ,Logistic regression ,Neuroimaging ,Internal medicine ,Humans ,Medicine ,Aged ,Retrospective Studies ,business.industry ,Parkinson Disease ,Retrospective cohort study ,Middle Aged ,medicine.disease ,LRRK2 ,Cross-Sectional Studies ,Neurology ,Case-Control Studies ,Mutation ,Mutation (genetic algorithm) ,Glucosylceramidase ,Anxiety ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,business - Abstract
BackgroundHigher prevalence of motor and non-motor features has been observed in non-manifesting mutation carriers of Parkinson’s Disease (PD) compared to Healthy Controls (HC).ObjectivesThe aim was to detect the differences between GBA and LRRK2 mutation carriers without PD and HC on neuropsychiatric symptoms.MethodsThis is a cross-sectional retrospective study of non-manifesting GBA and LRRK2 mutation carriers and HC enrolled into Parkinson’s Progression Markers Initiative (PPMI). Data extracted from the PPMI database contained: demographics and performance in MoCA scale and MDS-UPDRS scale part 1A (neuropsychiatric symptoms). All six features were treated as both continuous (MDS-UPDRS individual scores) and categorical variables (MDS-UPDRS individual score>0 and MDS-UPDRS individual score=0). Logistic regression analyses were applied to evaluate the association between mutation carrying status and neuropsychiatric symptoms.ResultsWe found that non-manifesting mutation carriers as a whole (total N=654, GBA: n=285, LRRK2: n=369) were 2.3 times more likely to present apathy compared to HC, even after adjustment for covariates (adjusted OR=2.3, 95% CI=1.1-5.0, p-value=0.027). The effect was mainly driven by GBA mutation carriers (adjusted OR= 2.6, 95% CI=1.1-6.3, p=0.031), while the higher percentage of apathy for LRRK2 carriers compared to HC was marginally non-significant. Other neuropsychiatric symptoms, such as psychotic or depressive manifestations, did not differ between groups.ConclusionsSymptoms of apathy could be present in the premotor period of LRRK2 and, especially, GBA mutation carriers. Longitudinal data, including detailed neuropsychiatric evaluation and neuroimaging, would be essential to further investigate the pathophysiological basis of this finding.
- Published
- 2021
27. Serum uric acid level as a putative biomarker in Parkinson's disease patients carrying GBA1 mutations: 2-Year data from the PPMI study
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Koros, Christos, Simitsi, Athina-Maria, Papagiannakis, Nikolaos, Bougea, Anastasia, Prentakis, Andreas, Papadimitriou, Dimitra, Pachi, Ioanna, Antonelou, Roubina, Angelopoulou, Efthalia, Beratis, Ion, Bozi, Maria, Papageorgiou, Sokratis G., Trapali, Xenia Geronicola, Stamelou, Maria, and Stefanis, Leonidas
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- 2021
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28. DEPENDENCY RELATIONSHIP OF EXERCISE AND MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS
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Christos Fragoulis, Andreas G. Prentakis, Evangelia Kontogianni, Dimitrios Polyzos, Ioannis Leontsinis, Emmanouil Mantzouranis, Theodoros Kalos, Antonios Politis, and Konstantinos Tsioufis
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Physiology ,Internal Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2022
29. Serum Uric Acid in LRRK2 Related Parkinson's Disease: Longitudinal Data from the PPMI Study
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Leonidas Stefanis, Roubina Antonelou, Anastasia Bougea, Maria Bozi, Dimitra Papadimitriou, Christos Koros, Xenia Geronicola Trapali, Maria Stamelou, Ioanna Pachi, Sokratis G. Papageorgiou, Ion Beratis, Efthalia Angelopoulou, Athina-Maria Simitsi, Nikolaos Papagiannakis, and Andreas Prentakis
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0301 basic medicine ,medicine.medical_specialty ,Parkinson's disease ,Longitudinal data ,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ,Gastroenterology ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Aged ,business.industry ,Serum uric acid ,Montreal Cognitive Assessment ,Parkinson Disease ,medicine.disease ,LRRK2 ,nervous system diseases ,Uric Acid ,030104 developmental biology ,chemistry ,Mutation ,Uric acid ,Biomarker (medicine) ,Geriatric Depression Scale ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Background: Previous studies have highlighted serum uric acid as a putative idiopathic Parkinson’s disease (iPD) biomarker. Only one study, so far, showed higher levels of serum uric acid in leucine-rich repeat kinase 2 (LRRK + 2) carriers compared to those who developed PD, however a longitudinal comparison between LRRK2 + PD and healthy controls (HC) has not been performed. Objective: The aim of this study was to determine whether there are longitudinal differences in serum uric acid between iPD, LRRK2 + PD and HC and their association with motor and non-motor features. Methods: Longitudinal data of uric acid of 282 de novo iPD, 144 LRRK2 + PD patients, and 195 age-matched HC were obtained from the Parkinson’s Progression Markers Initiative (PPMI) database. We also used longitudinal Montreal Cognitive Assessment (MoCA), Movement Disorder Society–Unified Parkinson’s Disease Rating Scale part III (MDS-UPDRS-III), Geriatric Depression Scale (GDS) scores, and DaTSCAN striatal binding ratios (SBRs). Results: Longitudinal uric acid measurements were significantly lower in LRRK2 + PD patients compared to HC up to 5 years follow-up. There was no significant impact or correlation of adjusted or unadjusted uric acid levels with MoCA, MDS-UPDRS III, or GDS scores, the presence of RBD or DAT-SCAN SBRs. Conclusion: LRRK2 + PD group had significantly lower uric acid concentrations compared to HC after adjusting for age, sex and baseline BMI up to 5 years follow-up. There were no significant associations between uric acid levels and indices of disease severity. These findings identify serum uric acid as a marker linked to LRRK2 + PD.
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- 2021
30. Apathy: an underestimated feature in GBA and LRRK2 non-manifesting mutation carriers
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Pachi, Ioanna, primary, Koros, Christos, additional, Simitsi, Athina M, additional, Papadimitriou, Dimitra, additional, Bougea, Anastasia, additional, Prentakis, Andreas, additional, Papagiannakis, Nikolaos, additional, Bozi, Maria, additional, Antonelou, Roubina, additional, Angelopoulou, Efthalia, additional, Beratis, Ion, additional, Stamelou, Maria, additional, Trapali, Xenia Geronicola, additional, Papageorgiou, Sokratis G., additional, and Stefanis, Leonidas, additional
- Published
- 2021
- Full Text
- View/download PDF
31. Serum Uric Acid in LRRK2 Related Parkinson's Disease: Longitudinal Data from the PPMI Study
- Author
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Bougea, A. Koros, C. Papagiannakis, N. Simitsi, A.-M. Prentakis, A. Papadimitriou, D. Pachi, I. Antonelou, R. Angelopoulou, E. Beratis, I. Bozi, M. Papageorgiou, S.G. Trapali, X.G. Stamelou, M. Stefanis, L.
- Subjects
nervous system diseases - Abstract
Background: Previous studies have highlighted serum uric acid as a putative idiopathic Parkinson's disease (iPD) biomarker. Only one study, so far, showed higher levels of serum uric acid in leucine-rich repeat kinase 2 (LRRK+2) carriers compared to those who developed PD, however a longitudinal comparison between LRRK2+PD and healthy controls (HC) has not been performed. Objective: The aim of this study was to determine whether there are longitudinal differences in serum uric acid between iPD, LRRK2+PD and HC and their association with motor and non-motor features. Methods: Longitudinal data of uric acid of 282 de novo iPD, 144 LRRK2+PD patients, and 195 age-matched HC were obtained from the Parkinson's Progression Markers Initiative (PPMI) database. We also used longitudinal Montreal Cognitive Assessment (MoCA), Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS-III), Geriatric Depression Scale (GDS) scores, and DaTSCAN striatal binding ratios (SBRs). Results: Longitudinal uric acid measurements were significantly lower in LRRK2+PD patients compared to HC up to 5 years follow-up. There was no significant impact or correlation of adjusted or unadjusted uric acid levels with MoCA, MDS-UPDRS III, or GDS scores, the presence of RBD or DAT-SCAN SBRs. Conclusion: LRRK2+PD group had significantly lower uric acid concentrations compared to HC after adjusting for age, sex and baseline BMI up to 5 years follow-up. There were no significant associations between uric acid levels and indices of disease severity. These findings identify serum uric acid as a marker linked to LRRK2+PD. © 2021 - IOS Press. All rights reserved.
- Published
- 2021
32. Apathy: An underestimated feature in GBA and LRRK2 non-manifesting mutation carriers
- Author
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Pachi, I. Koros, C. Simitsi, A.M. Papadimitriou, D. Bougea, A. Prentakis, A. Papagiannakis, N. Bozi, M. Antonelou, R. Angelopoulou, E. Beratis, I. Stamelou, M. Trapali, X.G. Papageorgiou, S.G. Stefanis, L.
- Abstract
Introduction: Higher prevalence of motor and non-motor features has been observed in non-manifesting mutation carriers of Parkinson's Disease (PD) compared to Healthy Controls (HC). The aim was to detect the differences between GBA and LRRK2 mutation carriers without PD and HC on neuropsychiatric symptoms. Methods: This is a cross-sectional retrospective study of non-manifesting GBA and LRRK2 mutation carriers and HC enrolled into Parkinson's Progression Markers Initiative (PPMI). Data extracted from the PPMI database contained: demographics and performance in MoCA scale and MDS-UPDRS scale part 1A (neuropsychiatric symptoms). All six features were treated as both continuous (MDS-UPDRS individual scores) and categorical variables (MDS-UPDRS individual score>0 and MDS-UPDRS individual score = 0). Logistic regression analyses were applied to evaluate the association between mutation carrying status and neuropsychiatric symptoms. Results: In this study, the neuropsychiatric evaluation was performed in 285 GBA non-manifesting carriers, 369 LRRK2 non-manifesting carriers and 195 HC. We found that GBA non-manifesting mutation carriers were 2.6 times more likely to present apathy compared to HC, even after adjustment for covariates (adjusted OR = 2.6, 95% CI = 1.1–6.3, p = 0.031). The higher percentage of apathy for LRRK2 carriers compared to HC was marginally non-significant. GBA carriers were 1.5 times more likely to develop features of anxiety compared to LRRK2 carriers (adjusted OR = 1.5, 95% CI = 1.1–2.2, p = 0.015). Other neuropsychiatric symptoms, such as psychotic or depressive manifestations, did not differ between groups. Conclusion: Symptoms of apathy could be present in the prediagnostic period of non-manifesting mutation carriers, especially, GBA. Longitudinal data, including detailed neuropsychiatric evaluation and neuroimaging, would be essential to further investigate the pathophysiological basis of this finding. © 2021
- Published
- 2021
33. CARDIORESPIRATORY INDICES IN RELATION TO MARKERS OF PSYCHOPATHOLOGY AND NEUROCOGNITIVE FUNCTION IN POST SARS-COV-2 INFECTED SUBJECTS
- Author
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Christos Fragoulis, Maria Kariori, Andreas G. Prentakis, Evangelia Kontogianni, Ioannis Leontsinis, Aggeliki Valatsou, Dimitris Konstantinidis, Maria Pirounaki, Constadina Aggeli, Christina Chrysochoou, Antonios Politis, Dimitrios Vassilopoulos, and Konstantinos Tsioufis
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2022
34. Serum Uric Acid in LRRK2 Related Parkinson’s Disease: Longitudinal Data from the PPMI Study
- Author
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Bougea, Anastasia, primary, Koros, Christos, additional, Papagiannakis, Nikolaos, additional, Simitsi, Athina-Maria, additional, Prentakis, Andreas, additional, Papadimitriou, Dimitra, additional, Pachi, Ioanna, additional, Antonelou, Roubina, additional, Angelopoulou, Efthalia, additional, Beratis, Ion, additional, Bozi, Maria, additional, Papageorgiou, Sokratis G., additional, Trapali, Xenia Geronicola, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional
- Published
- 2021
- Full Text
- View/download PDF
35. Serum uric acid level as a putative biomarker in Parkinson's disease patients carrying GBA1 mutations: 2-Year data from the PPMI study
- Author
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Anastasia Bougea, Maria Bozi, Ion Beratis, Sokratis G. Papageorgiou, Efthalia Angelopoulou, Leonidas Stefanis, Roubina Antonelou, Andreas Prentakis, Athina-Maria Simitsi, Maria Stamelou, Christos Koros, Xenia Geronicola Trapali, Nikolaos Papagiannakis, Ioanna Pachi, and Dimitra Papadimitriou
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Parkinson's disease ,Disease ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Serum uric acid level ,Humans ,Longitudinal Studies ,Aged ,Low serum uric acid ,business.industry ,Parkinson Disease ,Middle Aged ,medicine.disease ,Uric Acid ,030104 developmental biology ,Neurology ,chemistry ,Cohort ,Disease Progression ,Biomarker (medicine) ,Uric acid ,Glucosylceramidase ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Glucocerebrosidase ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Blood uric acid represents an important biomarker in sporadic Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is beginning to be assessed. The aim of the present study was to evaluate differences in serum uric acid level among PD patients harboring mutations in the glucocerebrosidase (GBA1) gene, sporadic PD, and healthy controls followed longitudinally.Longitudinal 2-year serum uric acid measurement data of 120 GBA-PD patients have been downloaded from the Parkinson's Progression Markers Initiative (PPMI) database. This cohort was compared with 369 de novo sporadic PD patients and 195 healthy controls enrolled in the same study.Following adjustment for age, sex and BMI the GBA-PD cohort exhibited lower 2-year longitudinal uric acid level as compared to the controls (p = 0.016). Baseline uric acid measurements showed only a marginal difference (p = 0.119), but year 2 uric acid levels were lower in the GBA-PD cohort (p 0.001). There was no difference in baseline, year 2 and 2-year longitudinal serum uric acid in the GBA-PD cohort as compared to sporadic PD (p = 0.664, p = 0.117 and p = 0.315).This is the first study to assess serum uric acid in a GBA-PD cohort. Our findings suggest that low serum uric acid might be a progression biomarker in GBA-PD. However, more studies (ideally longitudinal) on the association between low serum uric acid and clinical data in GBA-PD are needed. These results are consistent with data from previous reports assessing uric acid as a biomarker in other genetic forms of PD.
- Published
- 2020
36. Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson's Disease: Data from the PPMI Study
- Author
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Leonidas Stefanis, Roubina Antonelou, Ioanna Pachi, Dimitra Papadimitriou, Christos Koros, Xenia Geronicola Trapali, Ion Beratis, Andreas Prentakis, Anastasia Bougea, Efthalia Angelopoulou, Athina-Maria Simitsi, Maria Stamelou, Sokratis G. Papageorgiou, Nikolaos Papagiannakis, and Maria Bozi
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Parkinson's disease ,Disease ,Gastroenterology ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Epidemiology ,Medicine ,Serum uric acid level ,Humans ,Longitudinal Studies ,Aged ,Alpha-synuclein ,business.industry ,Serum uric acid ,Parkinson Disease ,Middle Aged ,medicine.disease ,Uric Acid ,030104 developmental biology ,chemistry ,alpha-Synuclein ,Biomarker (medicine) ,Uric acid ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Background Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. Objective The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. Methods Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers Initiative (PPMI) database. Furthermore, we assessed baseline serum uric acid measurements of 24 p.A53T alpha-synuclein PD patients enrolled in PPMI and followed in our site as compared to 24 age-, gender- and disease duration-matched sporadic PD patients and 24 healthy controls. Results Longitudinal serum uric acid measurements did not differ statistically between idiopathic PD patients and healthy controls (despite a trend for lower uric acid in the PD group) (p = 0.879). This was also true when male and female subgroups were assessed separately. The p.A53T SNCA mutation carrier PD group exhibited lower baseline serum uric acid level as compared to their matched healthy controls (p = 0.025). Conclusion In the present study we did not replicate the established lower serum uric acid measurements in PD patients as compared to controls using PPMI data, possibly due to the fact that PD patients in baseline visit were de novo and the average disease duration was shorter than that observed in most epidemiological PD studies. The faster progression rate and increased disease severity in p.A53T PD possibly correlate with the lower serum uric acid observed in this subgroup.
- Published
- 2020
37. DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study
- Author
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Koros, Christos Simitsi, Athina-Maria Prentakis, Andreas and Papagiannakis, Nikolaos Bougea, Anastasia Pachi, Ioanna and Papadimitriou, Dimitra Beratis, Ion Papageorgiou, Sokratis G. and Stamelou, Maria Trapali, Xenia Geronicola Stefanis, Leonidas
- Abstract
Introduction: It has been reported that early onset Parkinson’s Disease (PD) patients have a less profound dopaminergic degeneration. The aim of the current study was to determine whether there are longitudinal differences in dopaminergic denervation [signal reduction in 123I-FP-CIT SPECT] in early versus mid and late onset PD. Methods: DaTSCAN (123I-FP-CIT SPECT) imaging was acquired at Parkinson’s Progression Markers Initiative (PPMI) imaging centers and sent to the imaging core for calculation of striatal binding ratios. Data from the PPMI database of 58 early de novo PD patients (age 50 years). Results: Although raw striatal binding ratios were higher in early onset versus mid/late onset PD, especially on the ipsilateral side, such differences were not observed, and were in fact reversed in the contralateral putamen, after age correction. The rate of signal decline was similar between the two groups. Interestingly, based on both raw and age-adjusted data, caudate nucleus and putamen asymmetry (contralateral/ipsilateral ratio) was more pronounced in early onset PD. Striatal asymmetry also significantly correlated with age at onset as a continuous variable. Conclusion: Early onset PD patients exhibited similar rates of decline of dopaminergic denervation compared to mid/late onset PD. These results are not supportive of a more benign disease in this subgroup. The more pronounced asymmetry in early onset PD may however signify a qualitatively different pattern of neurodegeneration compared to mid/late onset PD.
- Published
- 2020
38. Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson?s Disease: Data from the PPMI Study
- Author
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Koros, Christos Simitsi, Athina-Maria Papadimitriou, Dimitra and Bougea, Anastasia Prentakis, Andreas Papagiannakis, Nikolaos and Pachi, Ioanna Bozi, Marria Antonelou, Roubina Angelopoulou, Efthalia Beratis, Ion Papageorgiou, Sokratis G. Trapali, Xenia Geronicola Stamelouaef, Maria Stefanis, Leonidas
- Abstract
Background: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. Objective: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. Methods: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers Initiative (PPMI) database. Furthermore, we assessed baseline serum uric acid measurements of 24 p.A53T alpha-synuclein PD patients enrolled in PPMI and followed in our site as compared to 24 age-, gender- and disease duration-matched sporadic PD patients and 24 healthy controls. Results: Longitudinal serum uric acid measurements did not differ statistically between idiopathic PD patients and healthy controls (despite a trend for lower uric acid in the PD group) (p = 0.879). This was also true when male and female subgroups were assessed separately. The p.A53T SNCA mutation carrier PD group exhibited lower baseline serum uric acid level as compared to their matched healthy controls (p = 0.025). Conclusion: In the present study we did not replicate the established lower serum uric acid measurements in PD patients as compared to controls using PPMI data, possibly due to the fact that PD patients in baseline visit were de novo and the average disease duration was shorter than that observed in most epidemiological PD studies. The faster progression rate and increased disease severity in p.A53T PD possibly correlate with the lower serum uric acid observed in this subgroup.
- Published
- 2020
39. 123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease
- Author
-
Christos Koros, Xenia Geronicola Trapali, Kenneth Marek, Nikolaos Papagiannakis, Andreas Prentakis, Stella Fragkiadaki, John Seibyl, Sokratis G. Papageorgiou, Maria Stamelou, Ion Beratis, Athina Simitsi, Dimitra Papadimitriou, Leonidas Stefanis, and Dionysia Kontaxopoulou
- Subjects
Denervation ,Alpha-synuclein ,medicine.medical_specialty ,Parkinson's disease ,medicine.diagnostic_test ,business.industry ,Putamen ,Point mutation ,Dopaminergic ,Urology ,Caudate nucleus ,Single-photon emission computed tomography ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Neurology ,chemistry ,medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background The p.A53T point mutation in the α-synuclein gene (SNCA) is a rare but highly relevant cause of autosomal dominant Parkinson's disease (PD). Objectives The objective of this study was to assess striatal dopaminergic denervation in a cohort of symptomatic carriers of the p.A53T SNCA mutation as compared to PD patients. Methods Data from the Parkinson's Progression Markers Initiative database of 11 symptomatic p.A53T SNCA mutation carriers who underwent 123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] imaging at our site were compared with those of 33 age-, sex-, and disease duration-matched PD patients. Results The p.A53T mutation carriers had significantly lower caudate nucleus binding ratio both contralaterally and ipsilaterally to the most affected side (P = .002 and P = .006) and a decreased contralateral caudate/putamen signal ratio (P = .007) as compared to PD. A similar degree of striatal asymmetry was observed in both subgroups. No correlation between scores in neuropsychological tests and caudate nucleus dopaminergic denervation could be demonstrated. Conclusions PD patients harboring the p.A53T SNCA mutation show evidence of a more severe nigrostriatal denervation, especially evident in the caudate nucleus. The lack of significant differences in the putaminal binding ratios may reflect a floor effect or a true preferential targeting of the caudate terminals in p.A53T SNCA-associated PD. © 2018 International Parkinson and Movement Disorder Society.
- Published
- 2018
40. Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson’s Disease: Data from the PPMI Study
- Author
-
Koros, Christos, primary, Simitsi, Athina-Maria, additional, Papadimitriou, Dimitra, additional, Bougea, Anastasia, additional, Prentakis, Andreas, additional, Papagiannakis, Nikolaos, additional, Pachi, Ioanna, additional, Bozi, Maria, additional, Antonelou, Roubina, additional, Angelopoulou, Efthalia, additional, Beratis, Ion, additional, Papageorgiou, Sokratis G., additional, Trapali, Xenia Geronicola, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional
- Published
- 2020
- Full Text
- View/download PDF
41. DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study
- Author
-
Ioanna Pachi, Anastasia Bougea, Leonidas Stefanis, Sokratis G. Papageorgiou, Andreas Prentakis, Nikolaos Papagiannakis, Christos Koros, Xenia Geronicola Trapali, Athina-Maria Simitsi, Ion Beratis, Dimitra Papadimitriou, and Maria Stamelou
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Parkinson's disease ,Dopamine ,Caudate nucleus ,Late onset ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Spect imaging ,medicine ,Humans ,Aged ,Denervation ,Tomography, Emission-Computed, Single-Photon ,Dopamine Plasma Membrane Transport Proteins ,business.industry ,Putamen ,Dopaminergic ,Neurodegeneration ,Parkinson Disease ,Middle Aged ,medicine.disease ,030104 developmental biology ,Early Diagnosis ,Neurology ,Cardiology ,Disease Progression ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,Caudate Nucleus ,business ,030217 neurology & neurosurgery ,Tropanes - Abstract
Introduction It has been reported that early onset Parkinson's Disease (PD) patients have a less profound dopaminergic degeneration. The aim of the current study was to determine whether there are longitudinal differences in dopaminergic denervation [signal reduction in 123I-FP-CIT SPECT] in early versus mid and late onset PD. Methods DaTSCAN (123I-FP-CIT SPECT) imaging was acquired at Parkinson's Progression Markers Initiative (PPMI) imaging centers and sent to the imaging core for calculation of striatal binding ratios. Data from the PPMI database of 58 early de novo PD patients (age ≤ 50 years) were compared to those of 362 mid and late onset PD patients (age > 50 years). Results Although raw striatal binding ratios were higher in early onset versus mid/late onset PD, especially on the ipsilateral side, such differences were not observed, and were in fact reversed in the contralateral putamen, after age correction. The rate of signal decline was similar between the two groups. Interestingly, based on both raw and age-adjusted data, caudate nucleus and putamen asymmetry (contralateral/ipsilateral ratio) was more pronounced in early onset PD. Striatal asymmetry also significantly correlated with age at onset as a continuous variable. Conclusion Early onset PD patients exhibited similar rates of decline of dopaminergic denervation compared to mid/late onset PD. These results are not supportive of a more benign disease in this subgroup. The more pronounced asymmetry in early onset PD may however signify a qualitatively different pattern of neurodegeneration compared to mid/late onset PD.
- Published
- 2019
42. 123I-FP-CIT SPECT [(123) I-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T alpha-synuclein Parkinson’s disease cohort versus Parkinson’s disease
- Author
-
Koros, Christos Simitsi, Athina Prentakis, Andreas Beratis, Ion Papadimitriou, Dimitra Kontaxopoulou, Dionysia and Fragkiadaki, Stella Papagiannakis, Nikolaos Seibyl, John and Marek, Kenneth Papageorgiou, Sokratis G. Trapali, Xenia Geronicola Stamelou, Maria Stefanis, Leonidas
- Abstract
Background: The p.A53T point mutation in the alpha-synuclein gene (SNCA) is a rare but highly relevant cause of autosomal dominant Parkinson’s disease (PD). Objectives: The objective of this study was to assess striatal dopaminergic denervation in a cohort of symptomatic carriers of the p.A53T SNCA mutation as compared to PD patients. Methods: Data from the Parkinson’s Progression Markers Initiative database of 11 symptomatic p.A53T SNCA mutation carriers who underwent 123I-FP-CIT SPECT [(123) I-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] imaging at our site were compared with those of 33 age-, sex-, and disease duration-matched PD patients. Results: The p.A53T mutation carriers had significantly lower caudate nucleus binding ratio both contralaterally and ipsilaterally to the most affected side (P = .002 and P = .006) and a decreased contralateral caudate/putamen signal ratio (P = .007) as compared to PD. A similar degree of striatal asymmetry was observed in both subgroups. No correlation between scores in neuropsychological tests and caudate nucleus dopaminergic denervation could be demonstrated. Conclusions: PD patients harboring the p.A53T SNCA mutation show evidence of a more severe nigrostriatal denervation, especially evident in the caudate nucleus. The lack of significant differences in the putaminal binding ratios may reflect a floor effect or a true preferential targeting of the caudate terminals in p.A53T SNCA-associated PD. (c) 2018 International Parkinson and Movement Disorder Society
- Published
- 2018
43. 123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease
- Author
-
Christos, Koros, Athina, Simitsi, Andreas, Prentakis, Ion, Beratis, Dimitra, Papadimitriou, Dionysia, Kontaxopoulou, Stella, Fragkiadaki, Nikolaos, Papagiannakis, John, Seibyl, Kenneth, Marek, Sokratis G, Papageorgiou, Xenia Geronicola, Trapali, Maria, Stamelou, and Leonidas, Stefanis
- Subjects
Adult ,Male ,Threonine ,Tomography, Emission-Computed, Single-Photon ,Alanine ,Dopamine ,Parkinson Disease ,Middle Aged ,Corpus Striatum ,Functional Laterality ,Cohort Studies ,Mutation ,alpha-Synuclein ,Humans ,Female ,Cognition Disorders ,Tropanes - Abstract
The p.A53T point mutation in the α-synuclein gene (SNCA) is a rare but highly relevant cause of autosomal dominant Parkinson's disease (PD).The objective of this study was to assess striatal dopaminergic denervation in a cohort of symptomatic carriers of the p.A53T SNCA mutation as compared to PD patients.Data from the Parkinson's Progression Markers Initiative database of 11 symptomatic p.A53T SNCA mutation carriers who underwent 123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] imaging at our site were compared with those of 33 age-, sex-, and disease duration-matched PD patients.The p.A53T mutation carriers had significantly lower caudate nucleus binding ratio both contralaterally and ipsilaterally to the most affected side (P = .002 and P = .006) and a decreased contralateral caudate/putamen signal ratio (P = .007) as compared to PD. A similar degree of striatal asymmetry was observed in both subgroups. No correlation between scores in neuropsychological tests and caudate nucleus dopaminergic denervation could be demonstrated.PD patients harboring the p.A53T SNCA mutation show evidence of a more severe nigrostriatal denervation, especially evident in the caudate nucleus. The lack of significant differences in the putaminal binding ratios may reflect a floor effect or a true preferential targeting of the caudate terminals in p.A53T SNCA-associated PD. © 2018 International Parkinson and Movement Disorder Society.
- Published
- 2017
44. Serum Uric Acid in LRRK2Related Parkinson’s Disease: Longitudinal Data from the PPMI Study
- Author
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Bougea, Anastasia, Koros, Christos, Papagiannakis, Nikolaos, Simitsi, Athina-Maria, Prentakis, Andreas, Papadimitriou, Dimitra, Pachi, Ioanna, Antonelou, Roubina, Angelopoulou, Efthalia, Beratis, Ion, Bozi, Maria, Papageorgiou, Sokratis G., Trapali, Xenia Geronicola, Stamelou, Maria, and Stefanis, Leonidas
- Abstract
Previous studies have highlighted serum uric acid as a putative idiopathic Parkinson’s disease (iPD) biomarker. Only one study, so far, showed higher levels of serum uric acid in leucine-rich repeat kinase 2 (LRRK + 2) carriers compared to those who developed PD, however a longitudinal comparison between LRRK2 + PD and healthy controls (HC) has not been performed. The aim of this study was to determine whether there are longitudinal differences in serum uric acid between iPD, LRRK2 + PD and HC and their association with motor and non-motor features. Longitudinal data of uric acid of 282 de novo iPD, 144 LRRK2 + PD patients, and 195 age-matched HC were obtained from the Parkinson’s Progression Markers Initiative (PPMI) database. We also used longitudinal Montreal Cognitive Assessment (MoCA), Movement Disorder Society–Unified Parkinson’s Disease Rating Scale part III (MDS-UPDRS-III), Geriatric Depression Scale (GDS) scores, and DaTSCAN striatal binding ratios (SBRs). Longitudinal uric acid measurements were significantly lower in LRRK2 + PD patients compared to HC up to 5 years follow-up. There was no significant impact or correlation of adjusted or unadjusted uric acid levels with MoCA, MDS-UPDRS III, or GDS scores, the presence of RBD or DAT-SCAN SBRs. LRRK2 + PD group had significantly lower uric acid concentrations compared to HC after adjusting for age, sex and baseline BMI up to 5 years follow-up. There were no significant associations between uric acid levels and indices of disease severity. These findings identify serum uric acid as a marker linked to LRRK2 + PD.
- Published
- 2021
- Full Text
- View/download PDF
45. Application of fuzzy logic for the assessment of engineering students
- Author
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Dimitrios A. Mitsoudis, Spyros S. Athinaios, Dimitrios Karolidis, Pantelis Prentakis, and Maria Samarakou
- Subjects
business.industry ,Computer science ,Learning environment ,05 social sciences ,050301 education ,02 engineering and technology ,Open learning ,Fuzzy logic ,Text comprehension ,Student assessment ,Learning styles ,0202 electrical engineering, electronic engineering, information engineering ,Mathematics education ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,0503 education - Abstract
In this paper, we present a fuzzy-logic based model for the diagnosis of the so-called students' learning profile. The fuzzy logic module is coupled with an interactive open learning environment (StuDiAsE) that incorporates the text comprehension theory by Denhiere and Baudet, the dialogue theory of Collins and Beranek, and the learning styles theory of Felder and Silverman. This intelligent learning environment is used for diagnosis, assistance and evaluation of engineering students. Preliminary tests for student assessment displayed high influence on the performance and motivation of its users.
- Published
- 2017
46. 123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease
- Author
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Koros, Christos, primary, Simitsi, Athina, additional, Prentakis, Andreas, additional, Beratis, Ion, additional, Papadimitriou, Dimitra, additional, Kontaxopoulou, Dionysia, additional, Fragkiadaki, Stella, additional, Papagiannakis, Nikolaos, additional, Seibyl, John, additional, Marek, Kenneth, additional, Papageorgiou, Sokratis G., additional, Trapali, Xenia Geronicola, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional
- Published
- 2018
- Full Text
- View/download PDF
47. Education, training, and professional issues of radiographers in six European countries: a comparative review
- Author
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Daniela Herlig, Shane Foley, Louise Coleman, Jolanta Tomczak, Sofia N. Chatziioannou, Antonis P. Stefanoyiannis, Anna Kowalik, Kostas Georgiadis, Andreas G. Prentakis, and Photis Kollas
- Subjects
International level ,education ,lcsh:LC8-6691 ,lcsh:R5-920 ,training ,Education training ,lcsh:Special aspects of education ,business.industry ,radiographer ,High education ,radiographer, education, training, practice, continuing professional development ,Common framework ,practice ,Nursing ,Continuing professional development ,Multidisciplinary approach ,Original Research Articles ,Medicine ,National registry ,business ,lcsh:Medicine (General) ,Research Article ,continuing professional development - Abstract
Radiographers constitute an important part of a multidisciplinary radiation-based imaging and therapy chain. However, is there a common framework for assuring high education, training, and subsequent practice of profession among European countries? A study was conducted, based on a questionnaire that consisted of three parts, concerning education and training (Part A), national registry (Part B), and professional issues (Part C). Analysis of the collected data suggested that a common policy is generally followed in the countries investigated; however, differences were not negligible. A common framework of educational programmes among European countries could form the basis for overall standardisation at national and international level.Keywords: radiographer, education, training, practice, continuing professional development(Published: 5 April 2016)Citation: Journal of European CME 2016, 5: 31092 - http://dx.doi.org/10.3402/jecme.v5.31092
- Published
- 2016
48. The Education and training of clinical medical physicists in 25 European, 2 North American and 2 Australasian countries: Similarities and differences
- Author
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X. Geronikola-Trapali, Stelios Christofides, A. Prentakis, W.H. Round, A.P. Stefanoyiannis, S.N. Chatziioannou, D. S. Geoghegan, I. Gerogiannis, P. A. Kaplanis, I. Armeniakos, and K. Psichis
- Subjects
Medical education ,medicine.medical_specialty ,Data collection ,Australasia ,business.industry ,Physics ,media_common.quotation_subject ,Physics education ,Biophysics ,MEDLINE ,General Physics and Astronomy ,General Medicine ,Certified Health Physicist ,Europe ,Service (economics) ,Family medicine ,North America ,Medicine ,Radiology, Nuclear Medicine and imaging ,Nuclear Medicine ,Duration (project management) ,business ,Inclusion (education) ,License ,media_common - Abstract
Purpose The clinical medical physicist is part of a team responsible for safe and competent provision of radiation-based diagnostic examinations and therapeutic practices. To ensure that the physicist can provide an adequate service, sufficient education and training is indispensable. The aim of this study is to provide a structured description of the present status of the clinical medical physicist education and training framework in 25 European, 2 North American and 2 Australasian countries. Methods For this study, data collection was based on a questionnaire prepared by the European Federation of Organizations in Medical Physics (EFOMP) and filled-in either by the corresponding scientific societies-organizations or by the authors. Results In the majority of cases, a qualified medical physicist should have an MSc in medical physics and 1–3 years of clinical experience. Education and training takes place in both universities and hospitals and the total duration of the programs ranges from 2.5 to 9 years. In 56% of all European countries, it is mandatory to hold a diploma or license to work as a medical physicist, the situation being similar in Australasian and 4 states of USA. Generally, there are national registers of medical physicists with inclusion on the register being voluntary. There are renewal mechanisms in the registers usually based on a Continuing Professional Development (CPD) system. Conclusions In conclusion, a common policy is followed in general, on topics concerning education and training as well as the practice of the medical physicist profession, notwithstanding the presence of a few differences.
- Published
- 2012
49. Effect of administered radioactive dose level on image quality of brain perfusion imaging with 99mTc-HMPAO
- Author
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X. Geronikola-Trapali, I. Gerogiannis, A. Prentakis, I. Armeniakos, and Antonis P. Stefanoyiannis
- Subjects
Image quality ,business.industry ,Significant difference ,brain perfusion imaging ,General Engineering ,Perfusion scanning ,Dose level ,quantitative evaluation ,99mTc-HMPAO ,lcsh:TA1-2040 ,Absorbed dose ,mental disorders ,lcsh:Technology (General) ,Tukey's range test ,lcsh:T1-995 ,Analysis of variance ,Psychology ,Nuclear medicine ,business ,lcsh:Engineering (General). Civil engineering (General) ,wavelet transform - Abstract
Brain perfusion imaging by means of 99mTc-labeled hexamethyl propylene amine oxime (HMPAO) is a well-established Nuclear Medicine diagnostic procedure. The administered dose range recommended by the supplying company and reported in bibliography is rather wide (approximately 9.5-27 mCi). This fact necessitates further quantitative analysis of the technique, so as to minimise patient absorbed dose without compromising the examination diagnostic value. In this study, a quantitative evaluation of the radiopharmaceutical performance for different values of administered dose (10, 15, 20 mCi) was carried out. Subsequently, a generic image quality index was correlated with the administered dose, to produce an overall performance indicator. Through this cost-to-benefit type analysis, the necessity of administration of higher radioactive dose levels in order to perform the specific diagnostic procedure was examined.Materials & methods: The study was based on a sample of 78 patients (56 administered with 10 mCi, 10 with 15 mCi and 12 with 20 mCi). Some patients were classified as normal, while others presented various forms of pathology. Evaluation of image quality was based on contrast, noise and contrast-to-noise ratio indicators, denoted CI, NI and CNR respectively. Calculation of all indicators was based on wavelet transform. An overall performance indicator (denoted PI), produced by the ratio of CNR by administered dose, was also calculated.Results: Calculation of skewness parameter revealed the normality of CI, NI and non-normality of CNR, PI populations. Application of appropriate statistical tests (analysis of variance for normal and Kruskal-Wallis test for non-normal populations) showed that there is a statistically significant difference in CI (p0.05) values. Application of Tukey test for normal populations CI, NI led to the conclusion that CI(10 mCi) = CI(20 mCi)NI(20 mCi), while NI(15 mCi) can not be characterised. Finally, application of non-parametric multiple comparisons showed that CNR(20 mCi)>CNR(10 mCi), while CNR(15 mCi) can not be characterised.Conclusion: Brain perfusion imaging by means of 99mTc- HMPAO utilising an administered dose of 20 mCi results in improved image quality, on the basis of the estimated indicators and for the range of radioactive dose levels examined. Additionally, this image quality improvement is sufficient to justify the increased radiation burden for the patient.
- Published
- 2008
50. Application of fuzzy logic for the assessment of engineering students
- Author
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Samarakou, Maria, primary, Prentakis, Pantelis, additional, Mitsoudis, Dimitrios, additional, Karolidis, Dimitrios, additional, and Athinaios, Spyros, additional
- Published
- 2017
- Full Text
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